KR102543302B1 - Cosmetic composition for skin whitening and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin whitening and a manufacturing method thereof and, more specifically, to a cosmetic composition for skin whitening, which not only exhibits excellent antioxidant and anti-inflammatory activities, but also exhibits a skin whitening effect by protecting damaged skin from external stimuli such as ultraviolet rays, and promotes collagen production, thereby preventing skin wrinkles and aging, and a manufacturing method thereof. To this end, the cosmetic composition for skin whitening comprises: a solvent including purified water and 1,2-hexanediol; glycerin; cetearyl olivate; non-polar moisturizing oil; sorbitan olivate; glutathione; an extract including at least one selected from the group consisting of hydrolyzed rye phytoplacenta extract, a shiitake mycelium extract, a salvia extract, a bakuchiol fruit extract, and combinations thereof; and spices.

Description

Cosmetic composition for skin whitening and its manufacturing method {COSMETIC COMPOSITION FOR SKIN WHITENING AND MANUFACTURING METHOD THEREOF}

The present invention relates to a cosmetic composition for skin whitening and a method for producing the same, and more specifically, exhibits excellent antioxidant and anti-inflammatory activity, and exhibits a skin whitening effect by protecting damaged skin from external stimuli such as ultraviolet rays, It relates to a cosmetic composition for skin whitening, which can prevent skin wrinkle formation and aging by promoting generation, and a method for manufacturing the cosmetic composition.

As the average lifespan has been extended due to the development of medical technology, the desire to maintain youth as long as possible has become a common concern for men and women of all ages, and the desire to prevent skin aging, which is most easily revealed, is increasing. Accordingly, research on the development of materials capable of finding the cause of skin aging and suppressing it is being actively conducted. Skin aging is divided into three main categories depending on the cause.

The first is natural aging (intrinsic aging). As the body ages, the body's immune system and physiological activity decline, preventing smooth recovery of skin components such as hyaluronic acid and collagen, resulting in reduced skin elasticity and dryness, resulting in fine wrinkles, etc. is formed Hyaluronic acid is one of the components of the extracellular matrix and accounts for only 0.1 to 0.2% in terms of dry weight, but forms a network with other components of the dermis to connect cells to each other, deliver nutrients, and prevent evaporation of moisture from the skin. At the same time, strong bonding with water molecules enables the skin to maintain a certain amount of moisture. The decrease of hyaluronic acid in the skin starts from the age of 18 to 20, and decomposition is accelerated with aging or by environmental pollution or exposure to ultraviolet rays. it can also be For this reason, approaches have been made to prevent aging by supplementing hyaluronic acid in the skin, which is reduced with age. In addition, since collagen accounts for 70 to 80% of the entire dermis, degradation of collagen is closely related to reduction of skin elasticity, skin whitening, and wrinkle formation.

Second, extrinsic aging is aging caused by external stress such as ultraviolet rays. Ultraviolet rays synthesize vitamin D in the body and have a role in sterilization, but also cause dermatitis, skin cancer, sunburn, skin aging, dryness, and fine wrinkles. Ultraviolet (UV) is divided into three types, A, B, and C, depending on the wavelength. Among them, UVC is blocked by the ozone layer, and UVA and UVB affect the skin.

In particular, when acutely or chronically exposed to medium-wavelength UVB (290-320 nm), it not only blackens the skin but also causes serious skin damage. It destroys hyaluronic acid, etc., and induces loss of skin elasticity, resulting in thick wrinkles. In addition, active oxygen generated by ultraviolet rays damages the intracellular signal transduction system and destroys collagen by increasing the expression of matrix metalloproteinase-1 (MMP-1), a collagen degrading enzyme in the skin.

Third, active oxygen that causes damage to skin cells can be mentioned. When excessively active oxygen is present, it breaks down the body's antioxidant defense system and damages cellular components such as proteins, lipids, and DNA. As a result, cell functions are altered and ultimately skin aging can be accelerated. In addition, active oxygen not only directly destroys collagen by acting on collagen metabolism, but also damages connective tissue by causing collagen deficiency. In addition, active oxygen has the ability to contain a large amount of water in the space between cells, maintaining skin elasticity and cutting the hyaluronic acid chain, which plays a role in absorbing shock, reducing skin elasticity and skin moisture. and thereby accelerate skin aging.

These active oxygen are generated not only from various factors that threaten our health, such as smoking, stress, excessive exercise, skin disease, viral infection, and ultraviolet rays, but also during the process of breathing and digestion, which are essential for maintaining life.

Therefore, it is required to develop a new cosmetic composition to protect the skin from the aging factors and improve damaged skin to maintain clear and elastic skin.

Republic of Korea Patent Publication No. 10-2000-0007648

The present invention is to solve the above problems, to provide a cosmetic composition that imparts excellent anti-inflammatory and antioxidant effects to the skin, and can exhibit skin whitening and anti-aging effects.

The above and other objects and advantages of the present invention will become apparent from the following description of preferred embodiments.

The above object is a solvent containing purified water and 1,2-hexanediol; glycerin; cetearyl olivate; non-polar moisturizing oil; sorbitan olivate; glutathione; An extract comprising at least one selected from the group consisting of hydrolyzed rye phytoplacenta extract, shiitake mushroom mycelium extract, salvia extract, bogolji fruit extract, and combinations thereof; It can be achieved by a cosmetic composition for skin whitening comprising; and fragrance.

Specifically, the non-polar moisturizing oil is at least one selected from the group consisting of hydrogenated olefin polymer, squalane, hydrogenated polydecene, caprylic/capric triglyceride, dicaprylyl ether, and combinations thereof It may be characterized by including.

Specifically, the cosmetic composition may be characterized in that it further comprises one or more additives selected from the group consisting of skin conditioning agents, thickeners, antioxidants, chelating agents, pigments, and combinations thereof.

Specifically, the skin conditioning agent, butylene glycol, niacinamide, thiamine HCL, pyridoxine, biotin, cyanocobalamin, riboflavin, polyacid, menadione, bioflavonoids, ascorbic acid, panthenol, tranec It may be characterized in that it includes at least one selected from the group consisting of samic acid, ethylhexylglycerin, and combinations thereof.

Specifically, the thickener is carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, dimethicone / vinyl dimethicone crosspolymer, dimethicone crosspolymer, vinyl dimethicone, hydroxy methylcellulose, It may be characterized in that it includes at least one selected from the group consisting of hydroxy ethyl cellulose, hydroxy propyl methyl cellulose, and combinations thereof.

Specifically, the antioxidant is one selected from the group consisting of tocopheryl acetate, hydroxyacetophenone, sodium ascorbyl phosphate, pentaerythrityltetra-di-t-butylhydroxyhydrocinnamate, and combinations thereof It may be characterized by including the above.

Specifically, the chelating agent includes at least one selected from the group consisting of disodium EDTA, sodium diphosphate, sodium triphosphate, nitrilotrimethylenephosphonic acid, ethylenediaminetetraacetate, and combinations thereof It can be characterized by doing.

Specifically, the cosmetic composition may be formulated with one or more selected from the group consisting of softening lotion, cream, ampoule, gel, cleansing foam, pack, spray, powder, and combinations thereof.

According to the present invention, when applied to the skin, it has excellent antioxidant activity and anti-inflammatory activity without causing safety problems such as irritation and redness as well as cytotoxicity, and can exhibit a skin whitening effect by protecting damaged skin from external stimuli such as ultraviolet rays. there is.

In addition, the cosmetic composition for skin whitening according to the present invention exhibits a non-sticky and moist finish and thus has excellent usability, and can exhibit excellent formulation stability without deformation such as layer separation even during long-term storage.

However, the effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the description below.

Figure 1 is a graph showing the change in the improvement rate of M-value (melanin index) over time measured using Mexameter ^® in a skin whitening effect test of a cosmetic composition for skin whitening according to an embodiment of the present invention.

Hereinafter, the present invention will be described in detail with reference to embodiments and drawings of the present invention. These examples are only presented as examples to explain the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples. .

In addition, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of skill in the art to which this invention belongs, and in case of conflict, this specification including definitions of will take precedence.

In order to clearly explain the proposed invention in the drawings, parts irrelevant to the description are omitted, and similar reference numerals are attached to similar parts throughout the specification. And, when a certain component is said to "include", this means that it may further include other components without excluding other components unless otherwise stated. Also, a “unit” described in the specification means one unit or block that performs a specific function.

In each step, the identification code (first, second, etc.) is used for convenience of description, and the identification code does not describe the order of each step, and each step does not clearly describe a specific order in context. It may be performed differently from the order specified above. That is, each step may be performed in the same order as specified, may be performed substantially simultaneously, or may be performed in the reverse order.

As used herein, the term "extract" refers to an extract obtained by extraction of raw material, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, a crude or purified product of the extract, or a mixture thereof, The extract itself and extracts of all formulations that can be formed using the extract may be included. The extract of the present invention may be extracted from natural, hybrid or mutant plants of each corresponding plant, and may also be extracted from plant tissue culture.

In the extraction of the raw material of the present invention, a method for extracting the extract is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include a hot water extraction method, an ultrasonic extraction method, a filtration method, a reflux extraction method, and the like, which may be performed alone or in combination of two or more methods.

In the present invention, the type of extraction solvent used to extract the raw material is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water; C1 to C4 lower alcohols such as methanol, ethanol, propyl alcohol and butyl alcohol; polyhydric alcohols such as glycerin, butylene glycol, and propylene glycol; and hydrocarbon solvents such as ethyl acetate; Or a mixture thereof may be used, and preferably, purified water, lower alcohol, 1,3-butylene glycol, and ethyl acetate may be used alone or in combination of two or more.

In the present invention, the extract obtained by hot water extraction or cold brewing is filtered to remove floating solid particles, for example, by filtering out particles using nylon or the like, or by using cryofiltration, and then used as is or freeze-dried or hot-air-dried. , spray drying, etc. can be used after drying.

Hereinafter, embodiments and embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. However, it may not be limited to these implementations and examples and drawings herein.

One aspect of the present application, a solvent containing purified water and 1,2-hexanediol; glycerin; cetearyl olivate; non-polar moisturizing oil; sorbitan olivate; glutathione; An extract comprising at least one selected from the group consisting of hydrolyzed rye phytoplacenta extract, shiitake mushroom mycelium extract, salvia extract, bogolji fruit extract, and combinations thereof; It provides a cosmetic composition for skin whitening comprising; and fragrance.

The cosmetic composition for skin whitening according to the present invention has excellent antioxidant activity and anti-inflammatory activity without causing safety problems such as irritation and redness as well as cytotoxicity when applied to the skin, and protects damaged skin from external stimuli such as ultraviolet rays. It has the advantage that it can exhibit a skin whitening effect, exhibits a moist finish without being sticky, and has excellent usability, and can exhibit excellent formulation stability without deformation such as layer separation even during long-term storage.

In one embodiment, the solvent may be included in about 75 to 85% by weight of the cosmetic composition. If the solvent is included in less than about 75% by weight, the components may not be sufficiently dissolved, and if it exceeds about 85% by weight, the skin whitening effect of the cosmetic composition may not be sufficiently exhibited.

In one embodiment, the glycerin is included for the skin moisturizing and skin improving effect of the cosmetic composition, and may be included in about 0.1 to 10% by weight in the cosmetic composition. If the glycerin is included in an amount of less than about 0.1% by weight, the effect resulting from the inclusion of the glycerin may not be sufficiently exhibited, and if it exceeds about 10% by weight, the feeling of use may be reduced.

In one embodiment, the cetearyl olivate is added to easily mix the components included in the cosmetic composition, and may be included in the cosmetic composition at about 0.1 to 10% by weight. If it is included in less than about 0.1% by weight, the components of the cosmetic composition may not be easily mixed with each other, resulting in aggregation or sinking, and if it exceeds about 10% by weight, too much foam may be generated. Preferably, the cetearyl olivate may be included in about 0.1 to 5% by weight.

In one embodiment, the non-polar moisturizing oil refers to hydrocarbon oils composed only of hydrocarbons, and at least one of them is selected and used. For example, it may include one or more selected from the group consisting of hydrogenated olefin polymer, squalane, hydrogenated polydecene, caprylic/capric triglyceride, dicaprylyl ether, and combinations thereof. . The non-polar moisturizing oil may exhibit skin elasticity improvement and skin soothing effects along with an excellent moisturizing effect. Specifically, the non-polar moisturizing oil may include caprylic/capric triglyceride.

In one embodiment, the caprylic / capric triglyceride may be contained in about 0.1 to 15% by weight of the cosmetic composition. If the caprylic / capric triglyceride is included in less than 0.1% by weight, the moisturizing, skin elasticity improvement and skin soothing effects caused by the inclusion of the non-polar moisturizing oil may not be sufficiently exhibited, and about 15% by weight If exceeded, layer separation may occur. Preferably, the caprylic/capric triglyceride may be included in an amount of about 1 to 10% by weight.

In one embodiment, the sorbitan olivate is added to easily mix the components included in the cosmetic composition, and may be included in the cosmetic composition at about 0.01 to 5% by weight. If it is included in less than about 0.1% by weight, the components of the cosmetic composition may not be easily mixed with each other, resulting in aggregation or sinking, and if it exceeds about 10% by weight, too much foam may be generated. Preferably, the sorbitan olivate may be included in about 0.1 to 5% by weight.

In one embodiment, the glutathione, as a crystalline peptide consisting of three amino acids, glutamic acid, cysteine, and glycine, and a strong antioxidant, can exhibit a high skin whitening effect when included in the cosmetic composition.

In one embodiment, the glutathione may be included in about 0.000001 to 0.001% by weight. If the glutathione is included in an amount of less than about 0.000001% by weight, the skin whitening effect resulting from the inclusion of the glutathione may not be sufficiently exhibited, and if the content exceeds about 0.001% by weight, skin irritation may occur.

In one embodiment, the extract may include one or more selected from the group consisting of hydrolyzed rye phytoplacenta extract, shiitake mushroom mycelium extract, salvia extract, bogolji fruit extract, and combinations thereof Specifically, it may include all of the hydrolyzed rye phytoplacenta extract, shiitake mushroom mycelium extract, salvia extract, and bogolji fruit extract.

In one embodiment, the hydrolyzed rye phytoplacenta extract may mean that rye Secale cereale's cipoplacenta is extracted and hydrolyzed with an acid, enzyme, or other method. The hydrolyzed rye phytoplacenta extract exhibits an excellent skin moisturizing effect and can protect the skin from irritation, thereby exhibiting a skin soothing effect.

In one embodiment, the hydrolyzed rye phytoplacenta extract may be included in about 0.000001 to 0.001% by weight. If the hydrolyzed rye phytoplacenta extract is included in an amount of less than 0.000001% by weight, the above-described effect may not be sufficiently exhibited, and if it exceeds about 0.001% by weight, mixability with other components may be impaired. .

In one embodiment, the shiitake mushroom mycelium extract may mean that the mycelium of shiitake mushroom was extracted by liquid culture. The shiitake mushroom mycelium extract exhibits excellent antioxidant and antibacterial properties, thereby exhibiting skin moisturizing and skin soothing effects, and may exhibit excellent formulation stability when added to a cosmetic composition.

In one embodiment, the shiitake mushroom mycelium extract may be included in about 0.00001 to 0.001% by weight. If the shiitake mushroom mycelium extract is included in less than 0.00001% by weight, the above-described effect may not be sufficiently exhibited, and if it exceeds about 0.001% by weight, mixability with other components may be impaired.

In one embodiment, the salvia extract, also called sage leaf extract, means obtained by hot water extraction of sage leaves. The salvia extract exhibits anti-inflammatory and antibacterial effects to help soothe problematic skin, and exhibits disinfection and sterilization effects, thereby exhibiting excellent formulation stability when added to a cosmetic composition.

In one embodiment, the salvia extract may be included in about 0.00001 to 0.001% by weight. If the salvia extract is included in an amount of less than 0.00001% by weight, the above-described effect may not be sufficiently exhibited, and if it exceeds about 0.001% by weight, mixing with other components may be impaired.

In one embodiment, the bogolji fruit extract may refer to an extract from the fruit of bogolji Psoralea corylifolia. The bogol berry extract contains a large amount of bakuchiol to exhibit antibacterial activity, and exhibits excellent anti-aging effect to exhibit skin whitening efficacy.

In one embodiment, the bogolji fruit extract may be included in about 0.00001 to 0.001% by weight. If the bogolji fruit extract is included in less than 0.00001% by weight, the above-described effect may not be sufficiently exhibited, and if it exceeds about 0.001% by weight, mixing with other components may be impaired.

In one embodiment, the spice is intended to improve consumer satisfaction by reducing an unpleasant odor, and may be included in an amount of about 0.01 to 3% by weight. If included in less than about 0.01% by weight, fragrance may not be improved, and if it exceeds about 3% by weight, skin irritation may occur.

In one embodiment, the cosmetic composition may further include a dragon fruit peel extract. The dragon fruit is a naturalized cultivated crop belonging to the cactus family, and its origin is called the Central American subtropical region or pitaya, and is also cultivated in Jeju, Korea. As the fruit ripens, the alkaloid pigment component increases, and because it is resistant to pests and pests, it can be cultivated without pesticides and is rich in carbohydrates, fiber, protein and fatty acids, so it is used as a healthy food. The dragon fruit peel extract is obtained by heating for about 18 hours to about 48 hours at a temperature range of about 25 ℃ to 45 ℃ after adding about 10 times the alcohol of dragon fruit skin, and the obtained extract is about 1,000 to about It may be obtained by centrifugation at 6,000 rpm and concentration under reduced pressure.

The mucilage contained in the peel of the dragon fruit promotes protein absorption and is known to protect the mucous membrane and relieve irritation such as itching when applied to the skin, and is also used as a natural moisturizer. In addition, it is derived from plants, so there are few allergies or side effects. Accordingly, the cosmetic composition containing the dragon fruit peel extract may exhibit antioxidant and anti-inflammatory effects, as well as skin whitening, skin soothing and skin regeneration effects.

In one embodiment, the dragon fruit peel extract may be included in about 0.01 to 1% by weight. If the dragon fruit peel extract is included in an amount of less than about 0.01% by weight, skin whitening, skin soothing and skin regeneration effects may not be sufficiently exhibited due to the inclusion of the dragon fruit skin extract, and if it exceeds about 1 weight %, skin irritation may occur. can represent

In one embodiment, the cosmetic composition may further include a bokryeong extract. The Bokryeong extract refers to an extract from the mycelium or sclerotium of Tuckahoe, a mushroom belonging to the basidiomycete Mushroom Order. The bokryeong contains triterpenoids such as eubricoic acid, pachymic acid, tumulosic acid and pinocolic acid, and thus sensitive skin due to dryness. It can soothe the reaction, purify the complexion of the skin, and show a skin whitening effect. In addition, since the Bokryeong extract does not show skin irritation, the cosmetic composition containing the Bokryeong extract can show the effect of improving skin by soothing problem skin such as acne and moisturizing the skin.

In one embodiment, the bokryeong extract may be contained in about 0.01 to 1% by weight. If, when the Bokryeong extract is included in less than about 0.01% by weight, the skin soothing and skin whitening effect that appears according to the inclusion of the Bokryeong extract may not be sufficiently exerted, and if it exceeds about 1% by weight, it may cause skin irritation.

In one embodiment, the cosmetic composition may further include sea buckthorn oil. The sea buckthorn oil may exhibit high antioxidant and anti-inflammatory effects by including vitamins, flavonoids, essential amino acids, and fatty acids. Specifically, the sea buckthorn oil contains abundant vitamins such as thiamine, riboflavin, and pyridoxine, vitamin A, vitamin K, and vitamin E, thereby providing vitality and elasticity to the skin, preventing wrinkles and aging, , It exhibits excellent antioxidant efficacy and can impart storage and formulation stability effects when additionally included in a cosmetic composition.

In one embodiment, the seabuckthorn oil may be contained in about 0.01 to 1% by weight. If the seabuckthorn oil is included in less than about 0.01% by weight, the storage and formulation stability effects resulting from the inclusion of seabuckthorn oil may not be sufficiently exhibited, and if it exceeds about 1% by weight, skin irritation may occur. .

In one embodiment, the cosmetic composition may further include one or more additives selected from the group consisting of skin conditioning agents, thickeners, antioxidants, chelating agents, pigments, and combinations thereof.

In one embodiment, the skin conditioning agent is butylene glycol, niacinamide, thiamine HCL, pyridoxine, biotin, cyanocobalamin, riboflavin, polyacid, menadione, bioflavonoids, ascorbic acid, panthenol , tranexamic acid, ethylhexylglycerin, and at least one selected from the group consisting of combinations thereof may exhibit skin soothing, skin whitening, and skin moisturizing effects. Specifically, the skin conditioning agent is butylene glycol, niacinamide, thiamine HCL, pyridoxine, biotin, cyanocobalamin, riboflavin, polyacid, menadione, bioflavonoids, ascorbic acid, panthenol, tranexamic It may contain both acid and ethylhexylglycerin.

In one embodiment, the components included in the skin conditioning agent may be included in about 0.000001 to 10% by weight, respectively. If it is included in less than about 0.000001% by weight, it may not be able to sufficiently exhibit the effect of including the above component, and if it exceeds about 10% by weight, it may cause skin irritation. For example, about 0.000001 to 10 weight percent, about 0.000001 to 0.00001 weight percent, about 0.0001 to 0.01 weight percent, about 0.01 to 1 weight percent, or about 1 to 10 weight percent.

In one embodiment, the thickener is included to adjust the viscosity of the cosmetic composition, for example, carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, dimethicone / vinyl dimethicone cross It may include at least one selected from the group consisting of a polymer, dimethicone crosspolymer, vinyl dimethicone, hydroxy methyl cellulose, hydroxy ethyl cellulose, hydroxy propyl methyl cellulose, and combinations thereof. Specifically, the thickener may include a carbomer.

In one embodiment, the carbomer may be included in about 0.01 to 3% by weight. If it is included in less than about 0.01% by weight, the cosmetic composition prepared may be too thin and the feeling of use may decrease, and if it exceeds about 3% by weight, sediment may occur.

In one embodiment, the antioxidant is to improve storage stability by preventing oxidation of the cosmetic composition to be prepared, for example, tocopheryl acetate, hydroxyacetophenone, sodium ascorbyl phosphate, pentaerythrityl tetra- di-t-butylhydroxyhydrocinnamate, and at least one selected from the group consisting of combinations thereof. Specifically, the antioxidant may include tocopheryl acetate.

In one embodiment, the tocopheryl acetate may be contained in about 0.000001 to 0.001% by weight. If it is included in less than about 0.000001% by weight, the storage stability of the cosmetic composition prepared may decrease, and if it exceeds about 0.001% by weight, mixing with other components may be inhibited.

In one embodiment, the chelating agent is one selected from the group consisting of disodium EDTA, sodium diphosphate, sodium triphosphate, nitrilotrimethylenephosphonic acid, ethylenediaminetetraacetate, and combinations thereof may contain more than Specifically, the chelating agent may include disodium EDTA.

In one embodiment, the chelating agent may be included in about 0.01 to 3% by weight of the cosmetic composition. If it is less than about 0.01% by weight, the stability of the cosmetic composition prepared may decrease, and if it exceeds about 3% by weight, skin irritation may occur.

In one embodiment, the above-described effect is exerted by organic interaction as all of the above-described components are included, and the above effect may not be achieved when the active ingredient is selectively included. .

In one embodiment, the cosmetic composition, in addition to the components described above, may additionally further include components typically required for preparing a cosmetic composition, but may not be limited thereto.

In one embodiment, the cosmetic composition may be formulated with one or more selected from the group consisting of softening lotion, cream, ampoule, gel, cleansing foam, pack, spray, powder, and combinations thereof.

In one embodiment, the cosmetic composition may add a material arbitrarily selected according to the cosmetic formulation or purpose of use. For example, purified water, oil, surfactants, moisturizers, higher alcohols, thickeners, chelating agents, pigments, fatty acids, antioxidants, preservatives, waxes, pH adjusters, fragrances, etc. may be added, but may not be limited thereto. there is.

In one embodiment, when the formulation of the cosmetic composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc as a carrier component Alternatively, zinc oxide may be included, but may not be limited thereto.

In one embodiment, when the formulation of the cosmetic composition is a powder or spray, it may include lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder as a carrier component, in particular, in the case of a spray, It may additionally include a propellant such as chlorofluorohydrocarbon, propane/butane or dimethyl ether, but may not be limited thereto.

In one embodiment, when the formulation of the cosmetic composition is a solution or emulsion such as softening lotion, it may contain a solvent, a solubilizing agent or an emulsifying agent as a carrier component, for example, water, ethanol, isopropanol, ethyl Carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan may be included, but may not be limited thereto.

In one embodiment, when the formulation of the cosmetic composition is a suspension such as an ampoule, water, a liquid diluent such as ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene as carrier components Suspending agents such as sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be included, but may not be limited thereto.

In one embodiment, when the formulation of the cosmetic composition is surfactant-containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate , sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters, but may not be limited thereto. there is.

Hereinafter, the configuration of the present invention and its effects will be described in more detail through specific examples and comparative examples. However, these examples are for explaining the present invention in more detail, and the scope of the present invention is not limited to these examples.

[Example 1]

A cosmetic composition for skin whitening in an ampoule formulation was prepared by uniformly mixing the components listed in Table 1 using an emulsifier, and was named Example 1.

Components (% by weight) Example 1 Purified water 82.507375 Butylene Glycol 7.738500 Niacinamide 2.200000 Cetearyl Olivate 1.641750 Sorbitan Olivate 1.355200 glycerin 1.188000 1,2-Hexanediol 0.780000 squalane 0.600000 Caprylic/Capric Triglyceride 0.600000 sodium hyaluronate 0.005000 biotin 0.000005 panthenol 0.050000 Thiamine HCL 0.000500 Cyanocobalamin 0.000005 Riboflavin 0.000005 pyridoxine 0.000500 Folic acid 0.000005 menadaion 0.000005 bioflavonoids 0.000005 Ascorbic Acid 0.000005 Tocopheryl Acetate 0.000005 glutathione 0.000005 Hyaluronic Acid 0.003000 cetyl palmitate 0.080000 Sorbitan Palmitate 0.060000 Tranexamic Acid 0.100000 Hydrolyzed Rye Phytoplacenta Extract 0.000100 Shiitake Mushroom Mycelium Extract 0.000010 Salvia Extract 0.000010 Bogolji Fruit Extract 0.000010 Cyclopentasiloxane 0.520000 Cyclohexasiloxane 0.280000 carbomer 0.100000 arginine 0.100000 Ethylhexylglycerin 0.050000 Disodium EDT 0.020000 Spices 0.020000 Sum 100.000000

[Example 2]

A cosmetic composition for skin whitening in a cream formulation was prepared by uniformly mixing the components listed in Table 2 using an emulsifier, and was named Example 2.

Components (% by weight) Example 2 Purified water 51.973079 glycerin 7.089500 Caprylic/Capric Triglyceride 6.050000 Butylene Glycol 5.511000 Polyglyceryl-3methylglucose distearate 3.300000 Cetylethylhexanoate 3.300000 Cetearyl Alcohol 3.080000 Pentaerythrityl Tetraisostearate 2.750000 vinyl dimethicone 2.530000 Niacinamide 2.200000 propanediol 1.650000 Glyceryl Stearate 1.320000 Cetearyl Olivate 1.188000 shea butter 1.100000 Thiamine HCL 0.000500 pyridoxine 0.000500 Hydrolyzed Rye Phytoplacenta Extract 0.000100 Shiitake Mushroom Mycelium Extract 0.000010 Salvia Extract 0.000010 Bogolji Fruit Extract 0.000010 biotin 0.000005 Cyanocobalamin 0.000005 Riboflavin 0.000005 Folic acid 0.000005 menadaion 0.000005 bioflavonoids 0.000005 Ascorbic Acid 0.000005 Tocopheryl Acetate 0.000005 glutathione 0.000005 titanium dioxide 0.900000 Sorbitan Olivate 0.720000 Hydroxyacetophenone 0.500000 pentylene glycol 0.500000 Hydrogenated vegetable oil 0.500000 beeswax 0.500000 Sorbitan Isostearate 0.500000 Palmitic Acid 0.493200 Hydroxyethyl Acrylate/Sodium Acryloyl Dimethyl Taurate Copolymer 0.480000 Stearic Acid 0.396000 Sodium Polyacryloyldimethyltaurate 0.315000 macadamia seed oil 0.300000 Hydrogenated polydecene 0.180000 panthenol 0.150000 Tranexamic Acid 0.100000 Glyceryl Acrylate/Acrylic Acid Copolymer 0.042240 Ethylhexylglycerin 0.040000 Tridecess-10 0.027000 1,2-Hexanediol 0.013000 Lauric Acid 0.005400 myristic acid 0.005400 carbomer 0.100000 tromethamine 0.100000 Disodium EDT 0.030000 Spices 0.060000 limonene 0.000001 Geraniol 0.000001 linalool 0.000004 Sum 100.000000

[Example 3 and Example 4]

The components listed in Table 3 were uniformly mixed using an emulsifier to prepare ampoule-type cosmetic compositions for skin whitening, which were named Examples 3 and 4, respectively.

Components (% by weight) Example 3 Example 4 Purified water 82.382375 79.382375 Butylene Glycol 7.738500 7.738500 Niacinamide 2.200000 2.200000 Cetearyl Olivate 1.641750 1.641750 Sorbitan Olivate 1.355200 1.355200 glycerin 1.188000 1.188000 1,2-Hexanediol 0.780000 0.780000 squalane 0.600000 0.600000 Caprylic/Capric Triglyceride 0.600000 0.600000 sodium hyaluronate 0.005000 0.005000 biotin 0.000005 0.000005 panthenol 0.050000 0.050000 Thiamine HCL 0.000500 0.000500 Cyanocobalamin 0.000005 0.000005 Riboflavin 0.000005 0.000005 pyridoxine 0.000500 0.000500 Folic Acid 0.000005 0.000005 menadaion 0.000005 0.000005 bioflavonoids 0.000005 0.000005 Ascorbic Acid 0.000005 0.000005 Tocopheryl Acetate 0.000005 0.000005 glutathione 0.000005 0.000005 Hyaluronic Acid 0.003000 0.003000 cetyl palmitate 0.080000 0.080000 Sorbitan Palmitate 0.060000 0.060000 Tranexamic Acid 0.100000 0.100000 Hydrolyzed Rye Phytoplacenta Extract 0.000100 0.000100 Shiitake Mushroom Mycelium Extract 0.000010 0.000010 Salvia Extract 0.000010 0.000010 Bogolji Fruit Extract 0.000010 0.000010 dragon fruit peel extract 0.050000 0.050000 Bokryeong Extract 0.075000 0.075000 Seabuckthorn Oil 0.000000 3.000000 Cyclopentasiloxane 0.520000 0.520000 Cyclohexasiloxane 0.280000 0.280000 carbomer 0.100000 0.100000 arginine 0.100000 0.100000 Ethylhexylglycerin 0.050000 0.050000 Disodium EDT 0.020000 0.020000 Spices 0.020000 0.020000 Sum 100.000000 100.000000

[Comparative Example]

The components listed in Table 4 were uniformly mixed using an emulsifier to prepare a cosmetic composition for skin whitening in the form of an ampoule, which was named a comparative example.

Components (% by weight) comparative example Purified water 81.563735 phenoxyethanol 3.000000 Butylene Glycol 7.738500 Niacinamide 2.200000 Cetearyl Olivate 1.641750 glycerin 1.188000 1,2-Hexanediol 0.780000 Caprylic/Capric Triglyceride 0.600000 sodium hyaluronate 0.005000 panthenol 0.050000 Riboflavin 0.000005 Ascorbic Acid 0.000005 Tocopheryl Acetate 0.000005 Hyaluronic Acid 0.003000 cetyl palmitate 0.080000 Sorbitan Palmitate 0.060000 Tranexamic Acid 0.100000 Cyclopentasiloxane 0.520000 Cyclohexasiloxane 0.280000 arginine 0.100000 Ethylhexylglycerin 0.050000 Disodium EDT 0.020000 Spices 0.020000 Sum 100.000000

[Experimental Example 1: Skin whitening effect measurement (in vivo)]

obtained in the above Examples and Comparative Examples The whitening effect of the cosmetic composition for skin whitening was confirmed through clinical trials. The experiment was conducted on 23 hypermelanin patients who met the selection criteria and were not included in the exemption criteria, and applied twice a day as a self-application method. The whitening effect was confirmed by M-value (hyperpigmentation improvement index) evaluation using Mexameter ^® , evaluation by subject, skin irritation evaluation by a dermatologist, and visual evaluation by a dermatologist.

1, the rate of improvement in hyperpigmentation of the cosmetic composition for skin whitening was obtained by measuring the difference between the M-value before the test and the M-value after the test in the control area and the test area. This is the result of expressing the improvement rate by time by expressing it as a percentage compared to the measured value before the test. Compared to the comparative example group, the cosmetic composition for skin whitening of Example significantly increased the hyperpigmentation improvement rate with application time after application to the skin.

The above results prove that the cosmetic composition for skin whitening of the present invention has a melanin reduction and thus a skin whitening effect.

[Experimental Example 2: Sensory Evaluation]

prepared in the above Examples and Comparative Examples Satisfaction including skin whitening, skin soothing, skin moisturizing retention, and skin regeneration effect of each cosmetic composition for skin whitening was confirmed through evaluation. The experiment was conducted on 90 men and women between the ages of 30 and 45 who met the selection criteria and were not included in the exemption criteria. They were divided into 15 people each and applied once a day for 4 weeks as a self-application method. The degree of preference felt by the subject was evaluated. The evaluation criteria were very good (5 points), excellent (4 points), average (3 points), poor (2 points), and very poor (1 point). Table 5 shows.

evaluation items Example 1 Example 2 Example 3 Example 4 comparative example skin whitening 4.2 4.1 4.5 4.8 2.9 soothe skin 4.4 4.3 4.5 4.8 3.6 No skin irritation 4.8 4.8 4.9 4.9 3.1 moisturizing the skin 4.0 4.2 4.2 4.3 3.0 skin regeneration 3.6 3.6 3.8 4.0 1.9 product satisfaction 4.5 4.5 4.6 4.9 3.0

As shown in Table 5, in the case of the cosmetic composition for skin whitening prepared according to the present invention, unlike the cosmetic composition of Comparative Example, most of the subjects showed skin whitening, skin soothing, skin moisturizing, skin regeneration, and non-irritation. Overall satisfaction was rated above average.

[Experimental Example 3: Stability Evaluation]

The stability of the cosmetic compositions for skin whitening prepared in Examples and Comparative Examples was evaluated. In the stability evaluation, it was visually determined whether component separation occurred when the prepared cosmetic compositions were left at room temperature (20° C.) or above room temperature (35° C.) for 3 months, respectively. The criterion was described as 'unstable' when the separation of components occurred, and 'stable' when the separation did not occur. The stability evaluation results are shown in Table 6 below.

temperature Example 1 Example 2 Example 3 Example 4 comparative example 20℃ stability stability stability stability stability 35℃ stability stability stability stability Instability

As shown in Table 6, the cosmetic composition for skin whitening of Examples according to the present invention, unlike the cosmetic composition of Comparative Example in which separation occurred when left at a temperature of 35 ° C. for 3 months, even when stored for a long time at room temperature or higher than room temperature. It was confirmed that it was stable without any separation phenomenon.

In this specification, only a few examples of various embodiments performed by the present inventors are described, but the technical spirit of the present invention is not limited or limited thereto, and can be modified and implemented in various ways by those skilled in the art, of course.

Claims (8)

75 to 85% by weight of purified water and a solvent including 1,2-hexanediol;
0.1 to 10% by weight of glycerin;
0.1 to 10% by weight of cetearyl olivate;
0.1 to 15% by weight of caprylic/capric triglyceride;
0.01 to 5% by weight of sorbitan olivate;
0.000001 to 0.001% by weight of glutathione;
0.01 to 3% by weight of carbomer;
0.000001 to 0.001% by weight of tocopheryl acetate;
0.01 to 3% by weight of disodium EDTA;
0.000001 to 0.001% by weight of hydrolyzed rye phytoplacenta extract;
Shiitake mushroom mycelium extract 0.00001 to 0.001% by weight;
Salvia extract 0.00001 to 0.001% by weight;
Bogolji fruit extract 0.00001 to 0.001% by weight;
Dragon fruit peel extract 0.01 to 1% by weight;
Bokryeong extract 0.01 to 1% by weight; and
0.01 to 3% by weight of perfume;
Containing, a cosmetic composition for skin whitening.
delete According to claim 1,
A cosmetic composition for skin whitening, further comprising one or more additives selected from the group consisting of skin conditioning agents, pigments, and combinations thereof.
The method of claim 3, wherein the skin conditioning agent,
Butylene Glycol, Niacinamide, Thiamine HCL, Pyridoxine, Biotin, Cyanocobalamin, Riboflavin, Polic Acid, Menadione, Bioflavonoids, Ascorbic Acid, Panthenol, Tranexamic Acid, Ethylhexylglycerin, These Characterized in that it comprises at least one selected from the group consisting of combinations, a cosmetic composition for skin whitening.
delete delete delete According to any one of claims 1, 3 or 4,
A cosmetic composition for skin whitening formulated with at least one selected from the group consisting of softening lotion, cream, ampoule, gel, cleansing foam, pack, spray, powder, and combinations thereof.

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