KR20000007648A - Cyclooxygenase-2 obstruction containing psoralea corylifolia extracts/or bakuchiol as effective component and anti-inflammation cosmetic material containing psoralea corylifolia extracts/or bakuchiol - Google Patents

Abstract

PURPOSE: The cosmetic material useful as cyclooxygenase-2 obstruction and an anti-inflammation curing medicine by improving the obstructive effect of the cyclooxygenase-2 is provided. CONSTITUTION: The extracts of Psoralea corylifolia acts the obstructive effect on the action of cyclooxygenase-2 caused by treating the macrophage separated from germinal cells of a mouse with LPS. The material is used as a curing medicine of various diseases such as arthritis, endotoxemia and so on having something to do with the cyclooxygenase-2 using the extracts of the Psoralea corylifolia. The Psoralea corylifolia is extracted with the number of carbon 1¯4 of anhydrous or hydrated alcohol, ethyl acetate or diethyl ether or is added to the cosmetic materials by extracting ethyl acetate or butanol or diethyl ether division among the non-containing water or containing water ethanol or methanol extracts.

Description

Anti-inflammatory cosmetics containing cyclooxygenase-2 inhibitors and golgol extract and / or bakuchiol as active ingredients of golgol extract and / or bakuchiol

The present invention relates to a novel use of the bone bone extract in a disease involving cyclooxygenase-2. In other words, the extract of Bogolgi shows an inhibitory effect on the activity of cyclooxygenase-2 induced by LPS treatment of macrophages isolated from alveoli of rats, and the present invention provides arthritis and endotoxemia. The present invention relates to a novel use of the bone bone extract as a therapeutic agent for various diseases involving cyclooxygenase-2.

The present invention also relates to a novel use of a single component, bakuchiol, isolated from a methanol extract of Bogolgol by silica gel column chromatography, for a disease involving cyclooxygenase-2. That is, bakuchiol exhibits an inhibitory effect on the activity of cyclooxygenase-2 induced by LPS treatment of macrophages isolated from rat alveoli. The present invention provides cyclooxygenase-2 such as arthritis and endotoxin It relates to a new use of bakuchiol as a therapeutic agent for various diseases involved.

The present invention also extracts golgolji with anhydrous or hydrous lower alcohol, ethylacetate or diethether having 1-4 carbon atoms, or extracts the ethylacetate, butanol or diethyl ether fraction in anhydrous or hydrous ethanol or methanol extract, In other words, it is added to the softening cream, nutrient cream, nourishing cream, massage cream, essence, pack, ointment.

It is known that various biochemical phenomena are involved in inflammatory action, and in particular, enzymes related to prostaglandin biosynthesis play an important role in mediating the inflammatory response. In particular, cyclooxygenase, an enzyme involved in synthesizing prostaglandins from arachidonic acid, has been a major goal in blocking inflammation. Recent research has shown that there are two cyclooxygenases. Cyclooxygenase-1 (hereinafter referred to as COX-1) is known to exhibit the action of synthesizing prostaglandins that are always present in cells and necessary for cytoprotective action. Cyclooxygenase-2 (hereinafter referred to as COX-2) Is known to play an important role in causing inflammatory reactions due to rapid increase in cells during inflammatory reactions. Therefore, an ideal anti-inflammatory material should have an inhibitory effect on COX-2.

Recently, NS-398, CGP-29238, SC-58125, L-745337, meloxicam, and the like have been reported as inhibitors for COX-2 produced by synthetic methods. Except that the extract has been reported to inhibit the COX-1 activity is not much research.

Moreover, there is no application example regarding COX-2 inhibitory action and anti-inflammatory action of Bogolji extract, and there is no application example regarding inhibitory action and anti-inflammatory action of cyclooxygenase-2 of bakuchiol.

Accordingly, the present inventors have completed the present invention by discovering that Bogolji extract and / or bakuchiol have a cyclooxygenase-2 inhibitory action and related anti-inflammatory action.

In other words, it is an object of the present invention to provide a golgogi extract and / or bakuchiol with cyclooxygenase-2 inhibitory activity and anti-inflammatory action associated therewith.

It is an object of the present invention to provide a cosmetic comprising Bogolgi extract and / or bakuchiol with cyclooxygenase-2 inhibitory action and anti-inflammatory action associated therewith.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

Bogolgol is the fruit of Psoralea corylifolia belonging to the legume (Leguminosae), and it is an annual herb of 40-90cm in height. The stems of this plant have yellowish-white hairs and dark brown dots, and the leaves regenerate. Fruits of these bones contain essential oils and organic acids, coronary artery dilation and antibacterial action.

In addition, bakuchiol, which is one of the components of the bone bone, has the action of antibacterial, corn, calcification of bone, and the like.

The present invention relates to new uses of such bones and / or bakuchiols. That is, bakuchiol, a single component isolated from Bogolgo extract and / or Bogolgol extract, was found to exhibit an inhibitory effect on the activity of cyclooxygenase-2 induced by LPS treatment of macrophages isolated from rat alveoli. In one aspect, the present invention is directed to a novel use of golgogi extract and / or bakuchiol as a therapeutic agent for various diseases involving cyclooxygenase-2, including arthritis, endotoxin, preterm birth, thrombus, asthma, psoriasis, and skin allergies. It is about.

The present invention also extracts golgolji with anhydrous or hydrous lower alcohol, ethylacetate or diethether having 1-4 carbon atoms, or extracts the ethylacetate, butanol or diethyl ether fraction in anhydrous or hydrous ethanol or methanol extract, In other words, it relates to anti-inflammatory cosmetics added to the softening cosmetics, nourishing cosmetics, nutrition cream, massage cream, essence, pack, ointment.

Cyclooxygenase-2 inhibitors according to the present invention is characterized in that Bogolji extract and / or bakuchiol as an active ingredient.

In addition, the anti-inflammatory therapeutic agent Bogolji extract and / or bakuchiol according to the invention is characterized in that the active ingredient.

In addition, the anti-inflammatory cosmetics according to the invention is characterized in that it contains a golgol extract.

In the present invention, the bones are not particularly limited, but it is preferable to use the bones belonging to legumes (Psoralea corylifolia).

The extract of Bogolji used in the present invention is preferably obtained by dipping with anhydrous or hydrous lower alcohol or ethyl acetate having 1 to 4 carbon atoms as a solvent, but is not limited thereto.

In the present invention, it is preferable that the anti-inflammatory cosmetics contain golgol extract in an amount of 0.0001-5% by weight. When Bogolgol extract is used at less than 0.0001% by weight, there is not much anti-inflammatory effect, and when it exceeds 5% by weight, it is economically undesirable in terms of cost.

Hereinafter, the present invention will be described in detail through Examples and Comparative Examples. However, the present invention is not limited to the examples described later.

Example 1 Preparation of Bogolgo Methanol Extract

Finely grind 100 g of Bolgol fruit, add 1 liter of methanol, boil for 4 hours in an extractor equipped with a cooling capacitor, cool, and filter it with Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 13.8 g.

Example 2 Preparation of Bogolgo Ethanol Extract

Grind 100g of golgol fruit finely, add 1 liter of ethanol, immerse for 10 days at 4-25 ℃, extract, cool, and filter with filter paper of Whatman 2. The extract was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 11.7 g.

Example 3 Preparation of Bogolgol Butanol Extract

Finely crush 100 g of golgol fruit, add 1 liter of normal butanol, dip it at 4-25 ° C for 10 days, extract it, cool it, and filter it with Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 9.4 g.

Example 4 Preparation of Bogolgol Echiacetate Extract

Finely crush 100 g of golgol fruit, add 1 liter of ethyl acetate, dip it at 4-25 ° C for 10 days, extract it, cool it, and filter it with Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 8.8 g.

Example 5 Preparation of Bogolji Nucleic Acid Extract

Finely grind 100 g of fruit from Bogolgol, add 1 liter of nucleic acid, dip it at 4-25 ° C for 10 days, extract it, cool it, and filter it with filter paper of Whatman 2. The extract was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling capacitor to obtain a dry weight of 0.9 g.

Example 6 Separation of Bakuchiol from the Methanol Extract of Bogolji

The Bogolgol extract obtained in Example 1 was loaded on the top of a tube filled with 100 g of silica gel, and passed through a mixed solvent of ethyl acetate-nucleic acid to obtain Compound H-136-C (10 g). H-136-C (100 mg) was loaded onto the run-on Kagel chromatography and run for 1 hour with an ethyl acetate-nucleic acid mixed solvent. Fractions showing activity were scraped off with a knife and eluted with a methanol-chloroform mixed solvent to obtain sample H-168-1 (60 mg).

Reference Example 1 Structure of Bakuchiol

Instrumental analysis was performed to identify the structure of the bakuchiol obtained in Example 6. ¹ H-NMR spectra and ¹³ C-NMR spectra are Zeol Lambda 400 (Japan) spectrometers, IR spectra are Bio-Rad FTS-40 spectrometers, and mass spectra are Zeol JMS-AX Each was measured using 505WA (Japan). the results are as follow.

IR ν max cm ^-1 (KBr): 3400, 2950, 2900 (See Figure 4)

¹ H-NMR (CDCl ₃ ): Table 1 (see Figure 5).

¹³ C-NMR (CDCl ₃ ): Table 2 (see Figure 6).

¹ H-NMR chemical shift (ppm) of isolated bakuchiol H Bakuchiol Literature Report 2 7.24 (d, J = 8.3) 7.22 (d, J = 7.2) 3 6.76 (d, J = 8.5) 6.74 (d, J = 7.2) 5 6.76 (d, J = 8.5) 6.74 (d, J = 7.2) 6 7.24 (d, J = 8.3) 7.22 (d, J = 7.2) 7 6.24 (d, J = 16.3) 6.23 (d, J = 16.2) 8 6.05 (d, J = 16.3) 6.03 (d, J = 16.2) 10 1.95 (m) 1.93 (m) 11 1.49 (m) 1.47 (m) 12 5.10 (bt) 5.09 (bt) 14 1.67 (s) 1.65 (s) 15 1.58 (s) 1.56 (s) 17 1.19 (s) 1.17 (s) 17 5.87 (dd, J = 10.8, 17.3) 5.86 (dd, J = 10.9, 17.3) 18 5.00 (m) 4.98 (m)

¹³ C-NMR chemical shift (ppm) of isolated bakuchiol C Bakuchiol Literature Report One 131.3 131.7 2 127.4 127.4 3 115.4 115.4 4 154.6 154.5 5 115.4 115.4 6 127.4 127.4 7 135.9 135.6 8 126.5 126.5 9 42.5 42.5 10 41.3 41.3 11 23.4 23.3 12 124.8 124.8 13 131.3 131.4 14 17.6 17.7 15 25.7 25.7 16 23.4 23.4 17 146.0 146.0 18 111.9 111.9

Test Example 1 Assay of COX-2 Activity Inhibition of Bogolji Extract and Bakuchiol

(1) Preparation of Alveolar Macrophages

Alveolar macrophages were isolated from Sprague-Dawley rats, 5-6 weeks old, according to Chandler and Fulmer's bronchoalveolar lavage method. 30 mL of cold PBS was added to the lung, and the liquid was collected. RPMI-1640 was added to and dispersed in the cell pellet obtained by centrifugation at 1500 rpm. Cell number and viability were determined by trypan blue exclusion using a hemocytometer. Cells are added to 24-well microtiter plates and incubated at 37 ° C. with 5% CO ₂ /95% O ₂ for 2 hours and then washed twice with culture to obtain macrophages. Purity of the obtained macrophages is usually 95% or more confirmed by differential counting.

(2) processing of samples

RPMI-1640 medium was added to macrophages obtained through Alveola Ravige and divided into (-) LPS, (+) LPS, aspirin (asp) positive control, and sample treatment group. It is then overnight in a CO ₂ incubator. After incubation, the whole medium of each well was taken, stored at -20 ° C, and used as a sample for RIA to measure the produced PEG ₂ .

(3) Test result

The amount of PEG ₂ produced by LPS-induced activity was 100% COX-2 activity, and the inhibitory effect of Bogolgogi extract and + control aspirin on COX-2 activity of LPS-treated macrophages was% activity. A comparison is shown in Figure 1. According to Figure 1, Bogolgol extracts were observed to dose-dependently inhibit COX-2 activity. Figure 2 shows the results of examining the inhibitory effect on COX-2 by varying the amount of acetylacetate extract, the most active of Bogolgol extract.

In addition, the inhibitory effect on the activity of COX-2 was examined for bakuchiol in the same manner as above. The result is shown in Figure 3. Figure 3 shows that bakuchiol, like Bogolji extract, inhibits COX-2 activity in a dose-dependent manner.

Test Example 2 Antioxidant Effect

Antioxidant effect of Bogolgo extract was measured as follows and compared with the effects of known antioxidants hydroquinone, vitamin E, ascorbic acid, caffeic acid, 3,4-dihydroxy benzoic acid.

(1) Test method

In 1.9 mL of 100 μm DPPH (diphenyl picryl hydrazile) ethanol solution, 0.1 mL of the sample solution to be tested at an appropriate concentration was added and reacted at 37 ° C. for 30 minutes. After the reaction, the absorbance was measured at 515 nm with an absorbance photometer.

(2) Test result

Antioxidant Effect of Bogolgo Extracts Experimental substance IC ₅₀ (μM) Pso-IV ^* 70 Ascorbic Acid 30 Alpha Tocopherol 35 Hydroquinone 25 3,4-dihydroxy benzoic acid 20 Cafe Iksan 23 ^* Pso-IV is Bogolgi extract extracted with ethyl acetate and expressed in μg / mL.

Test Example 3: Carrageenan-induced plantar edema inhibitory effect of golgogi extract

(1) Test method

Edema was induced by injecting 0.1 mL of a 1% carrageenan-saline solution into the sole of male Sprague-Daurey rats weighing 150-200 g. Edema rate was calculated by measuring the paw volume of rats immediately after carrageenan-induced inflammation and 3 hours after stimulation with a plethysmometer (Wugo Basil Company). The drug was administered 1 hour before carrageenan injection. Inhibitory efficacy was expressed as% inhibition compared to the edema rate of the vehicle administration group (see Equation 1).

In Equation 1, V represents a change in volume.

(2) Test result

Carrageenan-induced plantar edema results suppressed (n = 5-7) % Foot Volume Change (V) % Edema inhibition rate Edema rate in the control group 100 Herbal Medicine 10 mg / kg 80.5 ± 15.5 19.5 Herbal Medicine 30 mg / kg 64.0 ± 16.3 36 Herbal Medicine 100 mg / kg 44.3 ± 20.7 55.7 Indomethacin 10 mg / kg 30.5 ± 21.3 69.5

Test Example 4: Arachidonic acid-induced ear edema inhibitory effect of Bogolgo extract

(1) Test method

After applying 10 μl of ethanol in which 1 mg of arachidonic acid was dissolved in both ears of a mouse weighing 20-25 g, an appropriate amount of herbal sample solution dissolved in 10 μl of solvent was applied to the left ear. After 90 minutes, mice were killed with CO ₂ , and 6 mm diameter specimens were taken from the left and right ears of the mice and weighed. The inhibition rate is shown in Equation 2.

In Equation 2, X is the weight of the left ear treated with arachidonic acid (medicinal treatment site), Y is the weight of the left ear of control mice not treated with arachidonic acid, x is the weight of the right ear treated with arachidonic acid, and y is arachidone. The weight of the right ear of control mice not treated with acid is shown.

(2) Test result

Inhibition of Acaquidonic Acid-Induced Ear Edema by Bogolgol Extract Processing capacity % Edema inhibition rate (n = 5-7) Herbal medicine 1 mg 30.3 ± 7.3 3 mg herbal 37.4 ± 15.2 10 mg herbal 75.5 ± 10.3 Herbal Medicine 30 mg 89.2 ± 17.5 Indomethacin 2 mg 80.0 ± 15.3

Hereinafter, a prescription example of the cosmetic containing the golgol extract of the present invention will be described.

Prescription Example 1-3

Prescription examples of softening lotion (skin lotion) in cosmetics containing Bogolgol extract is as follows. Here Bogolji extract was used in Example 1.

Unit: weight% ingredient Prescription Example 1 Prescription Example 2 Prescription Example 3 Bone Golgi Extract 0.05 0.1 0.2 glycerin 3.0 - 2.0 Butylene glycol 3.0 - 4.0 Carboxy Vinyl Polymer 0.15 0.15 0.15 Nonylphenyl Ether 0.15 0.2 - Octyldodecyl ether 0.25 0.2 - P.O.60 Cured Castor Oil - - - Triethanolamine 0.15 0.15 0.15 antiseptic Quantity Quantity Quantity Spices Quantity Quantity Quantity ethanol 10.0 10.0 10.0 Pigment Quantity Quantity Quantity Purified water Remaining amount Remaining amount Remaining amount system 100.0 100.0 100.0

Prescription Example 4-6

A prescription example of nutritional cosmetics (milk skin lotion) in cosmetics containing Bogolgol extract is as follows. Here Bogolji extract was used in Example 1.

Unit: weight% ingredient Prescription Example 4 Prescription Example 5 Prescription Example 6 Bone Golgi Extract 0.5 0.2 0.1 glycerin 3.0 3.0 3.0 Butylene glycol 3.0 3.0 3.0 Carboxy Vinyl Polymer 0.15 0.15 0.15 Liquid paraffin 7.0 9.0 10.0 Squalane 4.0 2.0 2.0 Caprylic / Capric Triglycerides 3.0 3.0 - Cetostyryl alcohol 1.0 0.8 0.9 Stearic acid 0.5 0.6 0.5 Polysorbate 60 1.2 1.1 1.0 Sorbitan monosulfate 0.5 0.3 0.3 Triethanolamine 0.18 0.18 0.18 antiseptic Quantity Quantity Quantity Spices Quantity Quantity Quantity ethanol 3.0 3.0 3.0 Pigment Quantity Quantity Quantity Purified water Remaining amount Remaining amount Remaining amount system 100.0 100.0 100.0

Prescription Example 7-9

A prescription example of a massage cream in cosmetics containing Bogolji extract is as follows. Here Bogolji extract was used in Example 1.

Unit: weight% ingredient Prescription Example 7 Prescription Example 8 Prescription Example 9 Bone Golgi Extract 0.5 0.2 0.1 glycerin 3.0 4.0 5.0 Propylene glycol 3.0 3.0 2.0 Liquid paraffin 7.0 10.0 12.0 Squalane 4.0 2.0 3.0 Caprylic / Capric Triglycerides 3.0 3.0 4.0 Beeswax 4.0 5.0 4.0 Cetostyryl alcohol 2.0 2.5 2.5 Stearic acid 0.5 0.6 0.5 Polysorbate 60 1.2 1.0 1.0 Sorbitan monosulfate 0.5 0.6 0.5 antiseptic Quantity Quantity Quantity Spices Quantity Quantity Quantity Pigment Quantity Quantity Quantity Purified water Remaining amount Remaining amount Remaining amount system 100.0 100.0 100.0

Prescription Example 10-12

Prescription example of nutrition cream in cosmetics containing golgol extract is as follows. Here Bogolji extract was used in Example 1.

Unit: weight% ingredient Prescription Example 10 Prescription Example 11 Prescription Example 12 Bone Golgi Extract 0.01 0.05 0.1 glycerin 3.0 4.0 3.0 Butylene glycol 3.0 2.0 3.0 Liquid paraffin 35.0 40.0 45.0 Squalane 2.0 - - Caprylic / Capric Triglycerides 4.0 3.0 - Beeswax 3.0 3.5 4.0 paraffin 2.0 1.5 1.5 Vaseline 3.0 3.5 3.0 Cetostyryl alcohol 2.0 1.9 1.8 Glyceryl Monostearic Acid 2.0 2.5 2.0 Polyethylglycol Monostearate 2.2 2.3 2.5 Sesquioleic acid sorbitan 0.5 0.7 0.9 antiseptic Quantity Quantity Quantity Spices 0.01 0.05 0.1 Pigment Quantity Quantity Quantity Purified water Remaining amount Remaining amount Remaining amount system 100.0 100.0 100.0

Prescription Example 13-15

A prescription example of a pack in cosmetics containing Bogolgol extract is as follows. Here Bogolji extract was used in Example 1.

Unit: weight% ingredient Prescription Example 13 Prescription Example 14 Prescription Example 15 Bone Golgi Extract 0.01 0.05 0.1 glycerin 4.0 4.0 4.0 Polyvinyl alcohol 15.0 15.0 15.0 Allantoin 0.1 0.1 0.1 Polysorbate 60 0.5 0.5 0.5 Nonylphenyl Ether 0.4 0.5 0.4 antiseptic Quantity Quantity Quantity Spices Quantity Quantity Quantity ethanol 6.0 7.0 7.0 Pigment Quantity Quantity Quantity system 100.0 100.0 100.0

Prescription Example 16-18

Prescription examples of ointments in cosmetics containing golgol extract is as follows. Here Bogolji extract was used in Example 1.

Unit: weight% ingredient Prescription Example 16 Prescription Example 17 Prescription 18 Bone Golgi Extract 0.01 0.05 0.1 glycerin 3.0 3.0 3.0 Butylene glycol 3.0 2.0 1.0 Propylene glycol 3.0 1.0 2.0 Liquid paraffin 7.0 10.0 15.0 Squalane 4.0 1.0 1.0 Caprylic / Capric Triglycerides 3.0 3.0 - Beeswax 4.0 4.0 4.0 Cetostyryl alcohol 1.1 1.1 1.1 Polysorbate 80 5.0 5.0 5.0 Glycerin Monostearate 4.0 4.0 4.0 Sorbitan monosulfate 0.5 1.0 1.0 antiseptic Quantity Quantity Quantity system 100.0 100.0 100.0

As described above, according to the present invention, Bogolgogi extract and bakuchiol can be used not only as a cyclooxygenase-2 inhibitor and an anti-inflammatory agent, but also in the treatment of diseases related to cyclooxygenase-2. In addition, by applying the golgol extract or bakuchiol having such an effect to the cosmetics to improve the inhibitory effect of cyclooxygenase-2 can be obtained to alleviate or heal the disease associated with inflammation of the skin.

<Note>

Figure 1: Graph showing the effect of golgol extract on cyclooxygenase-2 activity of LPS-treated macrophages (Pso-I, Pso-II, Pso-III, Pso-IV, and Pso-V, respectively) Extracted with concentrated ethanol, butanol, ethyl acetate, nucleic acid and concentrated bone extract, Asp is aspirin as a control)

Figure 2: A graph showing the effect on the cyclooxygenase-2 activity of macrophages at different amounts of Bogolgi extract to be)

Figure 3: Graph showing the degree to which bakuchiol inhibits cyclooxygenase-2 in LPS-treated macrophages

Figure 4: IR spectrum of bagucciol

Figure 5: ¹ H-NMR spectrum of bakuchiol (500 MHz, CDCl ₃ )

Figure 6: ¹³ C-NMR spectrum of Bakuchiol (500 MHz, CDCl ₃ )

Claims (15)

Cyclooxygenase-2 inhibitor which has Bogolji extract as an active ingredient. The cyclooxygenase-2 inhibitor according to claim 1, wherein the bone bone is Psoralea corylifolia belonging to the legume. The cyclooxygenase-2 inhibitor according to claim 1, wherein the Bogolji extract is obtained by depositing anhydrous or hydrous lower alcohol or ethyl acetate having 1 to 4 carbon atoms as a solvent. Anti-inflammatory drugs with Bogolgol extract as an active ingredient. The anti-inflammatory agent according to claim 4, wherein the golgol is Psoralea corylifolia belonging to the legume. The anti-inflammatory agent according to claim 4, wherein the golgol extract is obtained by depositing anhydrous or hydrous lower alcohol or ethylacetate having 1 to 4 carbon atoms as a solvent. Cyclooxygenase-2 inhibitor which uses bakuchiol as an active ingredient. 8. The cyclooxygenase-2 inhibitor of claim 7, wherein the bakuchiol is isolated from Bogolchi extract. An anti-inflammatory drug with bakuchiol as an active ingredient. The anti-inflammatory agent according to claim 9, wherein the bakuchiol is isolated from Bogolgol extract. Anti-inflammatory cosmetics containing golgol extract. 12. The anti-inflammatory cosmetic according to claim 11, wherein the golgol is Psoralea corylifolia belonging to the legume. 12. The anti-inflammatory cosmetic according to claim 11, wherein the golgol extract is obtained by dipping anhydrous or hydrous lower alcohol or ethyl acetate having 1 to 4 carbon atoms as a solvent. The anti-inflammatory cosmetic composition of claim 11, wherein the Bogolgol extract is contained in an amount of 0.0001-5% by weight. The anti-inflammatory cosmetic according to claim 11, wherein the cosmetic is a softening cream, a nutrient cream, a nourishing cream, a massage cream, an essence, a pack, or an ointment.