KR102539681B1 - Clinical specimen container with normal saline inside - Google Patents

Abstract

A sample container in which the risk of exposure of workers to harmful substances is reduced and the force required for incision of the sealing sheet is reduced is provided. A sample container according to an exemplary embodiment of the present invention includes a container body in which physiological saline is accommodated in an internal space; a cap coupled to an upper portion of the container body and containing a preservation solution sealed therein; and a cutting unit coupled to a lower portion of the cap and including a cutting portion protruding upward.

Description

Sample container containing physiological saline inside {CLINICAL SPECIMEN CONTAINER WITH NORMAL SALINE INSIDE}

The present invention relates to a specimen container, and more particularly, to a specimen container containing physiological saline. More specifically, it relates to a specimen container capable of storing a specimen with only a small amount of preservative solution by accommodating physiological saline therein, and maintaining the preservative solution in a completely sealed state.

Smear test is one method of bacterial examination, which is a method of smearing a sample on a slide glass, staining the sample, and observing it under a microscope. For example, a bacterial smear test may be performed by applying a thin sample of cells, tissues, etc. collected from a human to a slide glass, selectively staining the sample, and then observing it under a microscope. A liquid-based cytology technique, which replaces the conventional cytology test (Papanicolaou), stores the collected cell sample in a preservation solution, and then places the cell sample in which the monolayer of preserved cells is uniformly dispersed on a slide for examination. was also developed. The liquid cytology test can improve the specificity and sensitivity of the test by improving cell fixation and minimizing unclear factors compared to the conventional cytology test.

Such a bacillus smear test has an advantage in that an active tuberculosis patient can be quickly discovered and treated compared to other methods because it can quickly check the presence of infection with only simple staining for bacteriological diagnosis.

On the other hand, tissue collected from a patient's lesion is transported to a place with testing equipment for an accurate diagnosis of a disease. In this case, the movement of the collected tissue needs to be preserved for a very long time, and therefore stored in a preservation solution (or fixative solution). Preservation solution has the function of maintaining and preserving the state at the time of collection so that the cell tissue that has been removed from the human body does not die, decompose, or change in shape, and maintains a state suitable for observing, analyzing, or making specimens of the cell tissue structure. do. As a preservation solution, a mixed solution containing formaldehyde is usually used.

Formaldehyde is most commonly used as a preservative because it has coagulation and polymerization of proteins. However, formalin (formaldehyde solution) is very toxic to the human body and is volatile, so care is required when handling it. In addition, when volatilized formalin is placed in the air for a long time, a first-class carcinogen may be generated. If a person is exposed to gaseous formalin, formaldehyde can penetrate through the skin or mucous membranes. In particular, a high degree of caution is required in handling formalin because continuous inhalation of formaldehyde can cause disorders of the central nervous system or heart failure.

However, in the process of preserving cells, inspectors such as clinicians or pathologists performing tests are always exposed to formalin. Therefore, when handling formalin, the inspector wears a gas mask to minimize the harmfulness caused by formalin, but nonetheless, the worker's health is exposed to harmful factors. For this reason, various attempts have been made to seal the preservative solution.

For example, Patent Document 1 (Korean Patent Registration No. 10-1880052) discloses a sample storage container including a container body, a cutter member, a preservative solution accommodating part, a lid, and a temporary member. In addition, Patent Document 2 (Korean Patent Registration No. 10-1934819) discloses a sample container including a sample container and a cap. Patent Document 1 and Patent Document 2 disclose a structure in which a sealing film for sealing a preservation solution is cut by rotating a container body and a lid.

As another example, Patent Document 3 (Korean Patent Registration No. 10-1874304) discloses a human tissue preservation device including a storage housing, a screen net, a selection member, a push rod, and an aluminum film. In addition, Patent Document 4 (Korean Patent Registration No. 10-1736745) discloses a specimen container for tissue preservation including a cap part, a housing, a slit part, and a support jaw. Patent Literature 3 and Patent Literature 4 disclose a structure in which a sealing film for sealing a preservation solution is cut by applying pressure to the lid.

Korean Patent Registration No. 10-1880052, (Patent Document 2) Korean Patent Registration No. 10-1934819, (Patent Document 3) Korean Patent Registration No. 10-1874304 (Patent Document 4) Korean Patent Registration No. 10 -1736745

The specimen containers of Patent Documents 1 to 4 described above are configured to seal the preservation solution using a sealing film and cut the sealing film through operation during use. However, there is a problem in that considerable force is required to cut the sealing film in Patent Documents 1 to 4. Some of the sample containers disclosed in the patent documents are on sale, but considerable force, for example, about 3 atm level, is required to cut the sealing film. In particular, many of the workers who perform this work in actual medical sites are female, and they apply pressure with both hands because they cannot incise the sealing membrane with one hand, or they drop the sample container in the process of applying pressure, causing bubbles and air bubbles to occur in the preservation solution. There are problems such as running out.

Meanwhile, the process in which the examiner is exposed to formalin may occur not only in the process of putting the cell sample into the specimen container, but also in the process of preparing formalin suitable for cell fixation. That is, workers may be exposed to formalin even in the process of preparing or preparing a preservative solution having an appropriate formaldehyde concentration and containing other additional components.

Accordingly, an object to be solved by the present invention is to provide a specimen container capable of easily incising a sealing sheet and mixing a preservation solution and a specimen even when an operator applies relatively little force. At the same time, it is an object of the present invention to provide a specimen container capable of further reducing the time for workers to be exposed to harmful substances such as formalin.

The tasks of the present invention are not limited to the technical tasks mentioned above, and other technical tasks not mentioned will be clearly understood by those skilled in the art from the following description.

A sample container according to an embodiment of the present invention for solving the above problems includes a container body in which physiological saline is accommodated in an internal space; a cap coupled to an upper portion of the container body and containing a preservation solution sealed therein; and a cutting unit coupled to a lower portion of the cap and including a cutting portion protruding upward.

The preservation solution may be formalin containing 35.0% to 40.0% of formaldehyde.

Here, after the physiological saline solution and the preservative solution are mixed, it may be configured to form a concentration of 8% to 12%.

In addition, in a state in which the container body and the cap are coupled, the physiological saline solution is completely sealed, and the coupling between the cap and the incision unit may be a non-rotational coupling.

A sample container according to another embodiment of the present invention for solving the above problems includes a container body accommodating a first liquid in an internal space; a cap coupled to an upper portion of the container body and containing a second liquid sealed therein, further including a sealing sheet sealing the second liquid; and a cutting unit coupled to a lower portion of the cap and including a cutout, wherein, when an external force is applied to the cap, the cutout cuts the sealing sheet from the lower side to the upper side, and the first liquid and the second It is configured to mix liquids.

A sample container according to another embodiment of the present invention for solving the above problems includes a cap including a sealing sheet and having a sealed first space therein; a container body reversibly coupled to a lower portion of the cap and having a second space, wherein the second space is closed when coupled with the cap, and the second space is opened when separated from the cap; a blocking ring disposed to be inserted between the cap and the container body in a state in which the cap and the container body are coupled; and a cutting unit that is reversibly coupled to a lower portion of the cap and inserted into the container body while the cap and the container body are coupled.

The cap includes a ceiling portion, a fastening body portion protruding downward from the ceiling portion and having a first screw thread formed on an inner surface, a first sidewall portion protruding downward from the ceiling portion and forming the first space, and the first sidewall portion. It may include the sealing sheet disposed at the bottom to seal the first space.

In addition, the container body includes a first bottom portion, a second side wall portion protruding upward from the first bottom portion and a second screw thread formed on the outer surface and forming the second space, and an upper portion from the first bottom portion. It may include a plurality of support parts that protrude into and form a height lower than the second side wall part, and a ring support part that protrudes from an outer surface of the second side wall part and is positioned below the second screw thread.

The cutting unit has a second bottom portion having a plurality of openings, a third side wall portion protruding upward from the second bottom portion, and a height that protrudes upward from the second bottom portion and is lower than the third side wall portion. It may include an incision to form.

Furthermore, the cap and the container body may be coupled by screwing through the first screw thread and the second screw thread.

The cap and the cutting unit may be press-fitted through an outer surface of the first sidewall portion and an inner surface of the third sidewall portion.

In addition, the blocking ring may be interposed between a lower surface of the fastening body and an upper surface of the ring supporter.

The cutting unit may further include a locking jaw protruding downward from the second bottom portion.

Here, in a state in which the cap, the container body, and the cap and the cutting unit are coupled, the lower surface of the second bottom part is in contact with the upper surface of the support part, and the lower surface of the locking jaw is positioned lower than the upper surface of the support part. can do.

In addition, the coupling between the cap and the cutting unit may be a rotation-limiting coupling.

The incision is a plurality of first incisions arranged in a circular shape, the first incision having a side surface of a curved surface and having an upper end forming a tip, and a second incision surrounded by the first incision from a planar viewpoint. The part may include a second cutout having a flat side and partitioning a space surrounded by the first cutout into a plurality of regions.

In addition, the maximum height of the first cutout may be greater than the maximum height of the second cutout.

In some embodiments, when the cap is rotated by 90 degrees or more relative to the container body, in a first angle range of less than 90 degrees, the cap and the cutting unit may be configured to rotate together.

Here, in a second angle range exceeding the first angle, the cap rotates, but the cutting unit may be configured such that rotation is limited due to interference between the support portion and the locking jaw.

When the cap is rotated with respect to the container body in a state in which the blocking ring is removed, the cap is screwed through the first screw thread and the second screw thread, and the cap is configured to move downward, and the cap and the interference fit The cutting unit is supported by the support and may be configured to limit downward movement.

Here, as the cap moves downward, the separation distance between the sealing sheet and the incision may be configured to gradually become closer.

Other embodiment specifics are included in the detailed description. In addition, the effects according to the embodiments of the present invention are not limited by the contents exemplified above, and more diverse effects are included in the present specification.

1 is a perspective view of a specimen container according to an embodiment of the present invention.
2 is an exploded perspective view of the sample container of FIG. 1;
3 is a cross-sectional perspective view of the sample container of FIG. 1;
Figure 4 is a perspective view of the cutting unit of Figure 1;
5 is a rear perspective view of the cutting unit of FIG. 4;
6 to 11 are views illustrating a process of using the sample container of FIG. 1 .

Advantages and features of the present invention, and methods of achieving them, will become clear with reference to the detailed description of the following embodiments taken in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in a variety of different forms, and only the embodiments make the disclosure of the present invention complete, and those skilled in the art in the art to which the present invention belongs It is provided to fully inform the person of the scope of the invention, and the invention is only defined by the scope of the claims.

That is, various changes may be made to the embodiments provided by the present invention. The embodiments described below are not intended to be limiting on the embodiments, and should be understood to include all modifications, equivalents or substitutes thereto.

Terminology used herein is for describing the embodiments and is not intended to limit the present invention. In this specification, 'and/or' includes each and every combination of one or more of the recited items. In addition, singular forms also include plural forms unless otherwise specified in the text.

The spatially relative terms 'below', 'beneath', 'lower', 'above', 'upper', etc. used in this specification are shown in the drawings. As such, it can be used to readily describe the relationship of one element or element to another element or element. Spatially relative terms are to be understood as encompassing different orientations of elements in use, as well as orientations shown in the drawings. For example, when a component shown in the drawing is turned over, a component described as 'below or beneath' another component may be placed 'above' the other component. Accordingly, the exemplary term 'below' may be used to include directions of both down and up.

As used herein, 'comprises' and/or 'comprising' does not exclude the presence or addition of one or more other elements other than the recited elements. A numerical range expressed using 'to' indicates a numerical range including the values listed before and after it as the lower limit and the upper limit, respectively. 'About' or 'approximately' means a value or range of values within 20% of the value or range of values set forth thereafter.

For convenience of explanation, the first direction (X) means any direction in a plane, and the second direction (Y) means a direction crossing the first direction (X) in the plane. In addition, the third direction (Z) means a direction perpendicular to the plane. However, it goes without saying that the matters described in the claims are not limited thereto. Unless otherwise defined, 'plane' means a plane to which the first direction (X) and the second direction (Y) belong. In addition, 'planar viewpoint' refers to a viewpoint in which the component represented in the drawing is viewed from one side in the third direction (Z) and the component is placed on the plane.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view of a specimen container 10 according to an embodiment of the present invention. FIG. 2 is an exploded perspective view of the sample container 10 of FIG. 1 . FIG. 3 is a cross-sectional perspective view of the sample container 10 of FIG. 1 . 4 is a perspective view of the cutting unit 301 of FIG. 1 . FIG. 5 is a rear perspective view of the cutting unit 301 of FIG. 4 .

1 to 5, the sample container 10 according to the present embodiment includes a cap 101 having a closed first space S1 and a container body 201 having an open second space S2. includes In addition, the specimen container 10 may further include a blocking ring 401 and a cutting unit 301. The sample container 10 may be a container for performing biopsy or liquid based cytology, but the present invention is not limited thereto.

First, the cap 101 will be described. The cap 101 may have an enclosed first space S1. A liquid material (eg, the first liquid F) may be accommodated in the first space S1 . For example, the liquid material may include a preservative solution (F) containing harmful components. The preservative solution (F) may be a solution containing high concentration of formaldehyde.

In some embodiments, the lower limit of the formaldehyde concentration of the preservative solution (F) is about 25.0% (v/v), or about 26.0% (v/v), or about 27.0% (v/v), or about 28.0% ( v/v), or about 29.0% (v/v), or about 30.0% (v/v), or about 31.0% (v/v), or about 32.0% (v/v), or about 33.0% ( v/v), or about 34.0% (v/v), or about 35.0% (v/v).

The upper limit of the concentration of formaldehyde in the preservation solution (F) is not particularly limited, but is, for example, about 50.0% (v/v), or about 49.0% (v/v), or about 48.0% (v/v), or about 47.0% (v/v), or about 46.0% (v/v), or about 45.0% (v/v), or about 44.0% (v/v), or about 43.0% (v/v), or about 42.0% (v/v), or about 41.0% (v/v), or about 40.0% (v/v).

Specifically, the cap 101 protrudes downward from the ceiling portion 111 at the top, the ceiling portion 111 and the fastening body portion 121 having the first screw thread 121s formed on the inner surface and the ceiling portion 111 protrudes downward, It may further include a first side wall portion 131 forming the first space S1 and a sealing sheet 150 disposed at a lower end of the first side wall portion 131 . The ceiling part 111, the fastening body part 121, and/or the first side wall part 131 may be integrally formed without a physical boundary with each other.

The ceiling portion 111 of the cap 101, the fastening body portion 121, and the first side wall portion 131 may be made of synthetic resin or the like. For example, a normal human grip force, such as about 100 kgf or less, or about 90 kgf or less, or about 80 kgf or less, or about 70 kgf or less, or about 60 kgf or less, or about 50 kgf or less is applied. It can have strength and rigidity that does not cause changes in appearance when applied. That is, the cap 101 is made of a material having high strength and rigidity that does not cause external deformation such as being broken, crushed, compressed, expanded, bent, bent, folded, or torn by a normal external force. can be made with Examples of the material may include a polycarbonate-based resin, but the present invention is not limited thereto.

The ceiling portion 111 may have a substantially circular shape when viewed from a plan view. The ceiling part 111 may be a part forming the outer upper surface of the cap 101 . In addition, the lower surface of the ceiling portion 111 may contribute to forming the first space S1.

The fastening body part 121 may protrude downward from the outer circumferential edge of the ceiling part 111 . The fastening body 121 may have a substantially annular shape. In an exemplary embodiment, the fastening body part 121 may have a means capable of being reversibly coupled to the container body 201 to be described below on its inner circumferential surface. For example, the coupling unit may be a first screw thread 121s. As used herein, the term 'reversible coupling' refers to a combination in which components can be repeatedly engaged and released without destruction or deformation of the components. When the cap 101 and the container body 201 are partially or completely coupled, the fastening body 121 may be located outside the container body 201 . That is, the inner diameter of the fastening body 121 may be larger than the outer diameter of the container body 201 to be described later.

The first sidewall portion 131 may protrude downward from the substantially central side of the ceiling portion 111 . The first sidewall portion 131 may have a substantially cylindrical shape with an open bottom. Also, when viewed from a plan view, the first side wall portion 131 may be surrounded by the fastening body portion 121 . The protruding length of the first sidewall portion 131 may be greater than the protruding length of the fastening body portion 121 . In a state in which the cap 101 and the container body 201 are partially or completely coupled, the first side wall portion 131 may be inserted into the container body 201 . That is, the outer diameter of the first side wall portion 131 may be smaller than the inner diameter of the container body 201 to be described later. The first side wall portion 131 and the fastening body portion 121 are spaced apart from each other, and a lower surface of the ceiling portion 111 may be partially exposed between them.

In some embodiments, the outer surface of the first side wall portion 131 may be in a flat state without a thread or the like. As will be described later through this, it is possible to form a rotational non-restrictive coupling with the cutting unit 301 . As used herein, the term 'rotational non-limiting coupling' refers to a coupling in which coupling and disengagement between components are not changed through relative rotation between components, and at the same time, other components are free to rotate relative to one component. Examples of non-rotation-limiting couplings include clip couplings, forced fitting couplings (or fitting couplings), and the like. In addition, the first side wall portion 131 may form a coupling with the cutting unit 301 to be described later and free movement in the vertical direction (ie, the third direction (Z)).

The sealing sheet 150 may have a substantially circular shape. The sealing sheet 150 may be disposed or adhered to the lower end of the first side wall portion 131 to form an airtight first space S1. That is, the lower surface of the ceiling portion 111, the inner surface of the first side wall portion 131 and the upper surface of the sealing sheet 150 may form a first space (S1) together.

The sealing sheet 150 may be made of a material through which liquid substances do not pass, and may be made of a material having weak strength and rigidity compared to the ceiling portion 111 of the cap 101 . For example, the sealing sheet 150 may be formed of a metal thin film such as silver foil, a synthetic resin thin film, etc., which may be partially cut, torn, damaged, or opened by a typical external force.

Next, the container body 201 will be described. The container body 201 may have an open second space S2. A liquid material (eg, the second liquid W) may be accommodated in the second space S2 . For example, the liquid material has a water content of about 95.0% (v/v) or more, or about 96.0% (v/v) or more, or about 97.0% (v/v) or more, or about 98.0% (v/v) or more. /v) or more, or about 99.0% (v / v) or more of the liquid material. or pure water.

In an exemplary embodiment, the second liquid W may include physiological saline solution having a sodium chloride (NaCl) concentration of 1.0% or less, or about 0.9%. When physiological saline is used as the second liquid (W), it is possible to minimize tissue deformation such as inflow of water into the specimen during the time after the first specimen is introduced and before mixing with the preservation liquid (F) (first liquid). However, the present invention is not limited thereto, and in another embodiment, the second liquid (W) may be in a state in which the physiological saline solution further includes additional ingredients, for example, other ingredients that are advantageous for preserving or fixing cells. That is, the second liquid (W) may be a solution in which 0.1% (v/v) to 1.0% (v/v) of sodium chloride is dissolved. Also, the volume of the second liquid (W) may be selected in consideration of the concentration and volume of the first liquid (F), but may be, for example, about 3 ml to 10 ml, or about 4 ml to 6 ml.

In addition, the second space S2 may provide a space in which a specimen such as a cell, tissue, or cellular tissue collected from a subject when using the specimen container 10 is accommodated. That is, the second liquid (W) may be located in the space where the specimen is accommodated. In general, during a cell collection process, an examiner such as a pathologist or clinician may grip a sample using a tool such as biopsy forceps or biopsies tweezers and insert it into the container body 201 . At this time, it is not easy to introduce the sample gripped by the tool into the container body 201 because it is common for samples such as tissues that are immediately collected to have viscosity. In particular, since the color of the tissue is usually light, white or transparent, it is not easy for the inspector to confirm whether the tissue cells are correctly inserted.

The sample container 10 according to the present embodiment accommodates a liquid substance, that is, the second liquid W, in the container body 201, and then puts the biopsy forceps holding the tissue cells into the second liquid W and stirs the tissue. It has the advantage of being able to easily take in samples such as cells. Accordingly, it is not necessary to apply physical force in the process of separating the sample from the tool, and thus problems such as crushing or damage of the sample can be minimized.

When the container body 201 and the cap 101 are separated, the second space S2 is an open space, but when the container body 201 and the cap 101 form a bond, the second space S2 can be completely sealed from the outside.

Specifically, the container body 201 protrudes upward from the first bottom portion 211 at the bottom and the first bottom portion 211, and a second screw thread 221s is formed on the outer surface to form a second space S2. A ring support 221k including a second side wall portion 221 and one or more support portions 251 protruding upward from the first bottom portion 211 and disposed on the outer circumferential surface of the second side wall portion 221 can include more. The first bottom part 211, the second side wall part 221, the support part 251, and/or the ring support part 221k may be integrally formed without physical boundaries.

The first bottom part 211, the second side wall part 221, the support part 251 and the ring support part 221k of the container body 201 may be made of synthetic resin or the like. For example, a change in appearance occurs when a normal human grip force, such as about 100 kgf or less, or about 90 kgf or less, or about 80 kgf or less, or about 70 kgf or less, or about 60 kgf or less, or about 50 kgf or less is applied It can have strength and rigidity that are not. That is, the container body 201 is made of a material with high strength and rigidity that does not cause external deformation such as being broken, crushed, compressed, expanded, bent, folded, or torn by a normal external force. can The container body 201 may be made of the same material as or a different material from the ceiling 111 of the cap 101 described above.

The first bottom part 211 may have a substantially circular shape when viewed from a plan view. The first bottom part 211 may be a part forming the exterior bottom surface of the container body 201 . In addition, the upper surface of the first bottom portion 211 may contribute to forming the second space S2.

The second sidewall portion 221 may protrude upward from the first bottom portion 211 . The second sidewall portion 221 may have a substantially cylindrical shape with an open top. The outer diameter of the second side wall portion 221 may be smaller than the inner diameter of the fastening body portion 121 , and the inner diameter of the second side wall portion 221 may be larger than the outer diameter of the first side wall portion 131 . Accordingly, the second side wall portion 221 may be partially inserted into the separation space between the aforementioned fastening body portion 121 and the first side wall portion 131 . In some embodiments, in a state in which the cap 101 and the container body 201 are completely coupled, for example, in a completely screwed state, the upper end of the second side wall portion 221 may come into contact with the lower surface of the ceiling portion 111. .

In an exemplary embodiment, the container body 201 may have a means capable of reversibly engaging with the aforementioned cap 101 on its outer circumferential surface. For example, the coupling unit may be a second screw thread 221s. In order to use the sample container 10 according to the present embodiment for a liquid cell test, coupling and disengagement between the cap 101 and the container body 201 are required multiple times. For example, it is necessary to release and combine once to introduce the sample into the second space S2 of the container body 201, and to smear the stored sample, it is necessary to release and combine again to take out the sample. can The specimen container 10 according to the present embodiment adopts screw coupling as a coupling between the cap 101 and the container body 201, so that reversible coupling is possible and easy coupling and disengagement is possible.

In addition, the first screw thread 121s and the second screw thread 221s may be configured to be screwed in a predetermined angular relationship. The screw-in angle of the first screw thread 121s and the second screw thread 221s is preferably large in order to form a complete coupling between the cap 101 and the container body 201 and to prevent leakage of the liquid contained therein.

In the sample container 10 according to this embodiment, in a state in which the blocking ring 401 described later is removed, the screw tightening angle when the first screw thread 121s and the second screw thread 221s are completely screwed is 270 greater than about 280 degrees, or greater than about 290 degrees, or greater than about 300 degrees, or greater than about 310 degrees, or greater than about 320 degrees, or greater than about 330 degrees, or greater than about 340 degrees, or greater than about 350 degrees , or may be coupled at an angle of about 360 degrees or more. That is, when the separated cap 101 is placed on top of the container body 201 and screwed together, it may be rotated at least three quarters of a turn or more, preferably at least one turn.

In addition, the upper limit of the screw-in angle when the first screw thread 121s and the second screw thread 221s are completely screwed is about 400 degrees, or about 390 degrees, or about 380 degrees, or about 370 degrees, or about 360 degrees. degrees, or about 350 degrees. A screw tightening angle between the first screw thread 121s and the second screw thread 221s may have a predetermined relationship with a locking jaw 371 of the cutting unit 301 to be described later. This will be described later in detail.

In some embodiments, in a state in which the blocking ring 401 described later is not removed, that is, in a state in which the second thread 221s and the blocking ring 401 are disposed to overlap, the first thread 121s and the second thread 221s When the thread 221s is completely screwed in, the screw-in angle may be about 60 degrees or more, about 70 degrees or more, about 80 degrees or more, or about 90 degrees or more.

The support part 251 may protrude upward from the first bottom part 211 . The support part 251 may have a bar shape protruding upward from the first bottom part 211 . In addition, the support portion 251 may be surrounded by the second side wall portion 221 when viewed from a plan view. The protruding length of the support part 251 may be smaller than the protruding length of the second side wall part 221 . That is, the upper end of the support part 251 may form a lower height than the upper end of the second side wall part 221 .

One or more supporters 251 may be provided. For example, a total of four may be arranged at 90 degree intervals. In the cross-sectional perspective view of FIG. 3, three support parts 251 are expressed, and the drawing illustrates a case in which a total of four support parts 251 (including parts not represented in the cross-sectional perspective view) are disposed, but the present invention is not limited thereto. no. In another embodiment, there may be only one support 251 . However, at least one of the support portion 251 and the locking jaw 371 to be described later may be plural.

The support part 251 may function to form a step difference relative to the inner surface of the second side wall part 221 . During the coupling process between the cap 101 and the container body 201, it may serve to support the lower surface of the cutting unit 301 in the direction of gravity (eg, in the third direction Z). This will be described later in detail.

The ring support 221k may be located on the outer circumferential surface of the container body 201 . The ring support 221k may have a substantially annular shape in plan view. The ring support portion 221k is positioned on the outer circumferential surface of the container body 201 like the second screw thread 221s, but may be positioned lower than the second screw thread 221s. The ring support 221k may function to support the blocking ring 401 to be described later in the direction of gravity (eg, in the third direction Z).

The protrusion length of the ring support 221k in the horizontal direction (eg, the first direction (X), the second direction (Y), or the plane direction to which the first direction (X) and the second direction (Y) belong) is It may be greater than the protrusion of the second screw thread 221s in the horizontal direction. That is, when the container body 201 is viewed from the lower side in the third direction (Z), the second screw thread (221s) is hidden by the ring support portion (221k) and is not visible, and when viewed from the upper side in the third direction (Z), the second screw thread (221s) is invisible. Both the screw thread 221s and the ring support 221k may be visible.

Next, the blocking ring 401 will be described. The blocking ring 401 may be an annular ring member. The blocking ring 401 may have a predetermined length in the third direction (Z). The blocking ring 401 may be configured to be inserted and disposed between the cap 101 and the ring support 221k of the container body 201 in an initial state, and then removed when the sample container 10 is used. The blocking ring 401 prevents (blocking) the coupling between the cap 101 and the container body 201 above a predetermined standard so that the cutout 351 of the cutting unit 301 to be described later does not cut the sealing sheet 150 function can be performed. Specifically, the blocking ring 401 may prevent the cap 101 from moving downward beyond a predetermined reference level with respect to the container body 201 .

The inner diameter of the blocking ring 401 may be larger than the outer diameter of the second side wall portion 221 of the container body 201 . More specifically, the inner diameter of the blocking ring 401 may be greater than the sum of twice the outer diameter of the second side wall portion 221 and the protruding length of the second screw thread 221s. In an initial state, the blocking ring 401 is disposed on the ring support 221k, and the container body 201 may be inserted into the blocking ring 401. For example, the upper end of the blocking ring 401 is in contact with the lower end of the fastening body 121 of the cap 101, and the lower end of the blocking ring 401 is the upper surface of the ring support 221k of the container body 201. In contact with the container body 201, the ring support portion 221k and the cap 101 of the fastening body portion 121 may be inserted between the arrangement. Also, the distance between the container body 201 and the cap 101 in the third direction (Z) may be fixed through partial screwing. Also, in the initial state, the blocking ring 401 may overlap the second screw thread 221s in the first direction (X) and in the second direction (Y).

In an exemplary embodiment, the length of the blocking ring 401 in the third direction (Z) may be smaller than the length from the ring support portion 221k to the upper end of the second sidewall portion 221 . That is, in a state where the blocking ring 401 is placed on the ring support 221k, an upper part of the second screw thread 221s may be partially exposed. The blocking ring 401 may be made of the same or different material as the cap 101 and/or container body 201 described above.

Next, the cutting unit 301 will be described. The cutting unit 301 may be reversibly coupled to the lower portion of the cap 101, specifically, to the lower portion of the first sidewall portion 131. When the cap 101 and the cutting unit 301 are coupled, and the cap 101 and the container body 201 are partially or completely coupled, the cutting unit 301 is inserted into the container body 201 and disposed. can The cutting unit 301 is between the cap 101 and the container body 201, specifically, the first liquid (F) accommodated in the first space (S1) to the second liquid (W) side of the second space (S2) It can be located on the flowing fluid path. More specifically, after the sealing sheet 150 is cut, the first liquid (F) may be located on a path flowing toward the second liquid (W) by gravity.

The cutting unit 301 may function to cut the sealing sheet 150 by including a plurality of cutouts 351 protruding upward. That is, the specimen container 10 according to the present embodiment may be configured so that the cutting portion 351 of the cutting unit 301 cuts the sealing sheet 150 from the bottom to the top. Accordingly, for example, the first liquid F is poured into the second space S2 by gravity, and the first liquid F and the second liquid W may be mixed. In an exemplary embodiment, when the first liquid (F) is formalin and the second liquid (W) is physiological saline, the concentration of formaldehyde in the mixture of the first liquid (F) and the second liquid (W) is about 6.0 % (v/v) to 15.0% (v/v), or about 7.0% (v/v) to 14.0% (v/v), or about 8.0% (v/v) to 13.0% (v/v) , or about 8.0% (v/v) to 12.0% (v/v).

As described above, the volume of formalin sealed in the cap 101 may be reduced by preparing formalin having a relatively high concentration as the first liquid F. Although the present invention is not limited thereto, for example, when the second liquid (W) is prepared by being injected by an operator, the sample container 10 accommodating only the first liquid (F) can be significantly reduced in weight. there is. Therefore, there is an advantage in that a larger amount of sample container 10 can be transported and transported at one time. In particular, when classified as a hazardous material, such as formalin, restrictions may occur on handling, transport, storage, and the like, and minimizing the volume and weight of formalin may serve as an advantage.

In addition, during the process of preparing or preparing a preservative solution having appropriate components and appropriate concentrations suitable for cell fixation, inspectors such as clinicians and pathologists may be continuously exposed to formalin. In the sample container 10 according to the present embodiment, the first liquid (F) having a high concentration of formaldehyde including harmful components is kept sealed, but the second liquid (W) for mixing or concentration dilution of additional components is maintained. ), it has the effect of significantly reducing the frequency and time that workers are exposed to formaldehyde.

Also, the cutting unit 301 may have a cutting function and a filter (filtration) function at the same time. The cutting unit 301 may penetrate a liquid material, but may not penetrate a specimen such as a cell tissue having a predetermined size or more. For example, tissue contained in the container body 201 may not move toward the cap 101 . On the other hand, the first liquid F and the second liquid W may pass through the cutting unit 301 and move in opposite directions.

Specifically, the cutting unit 301 includes a second bottom portion 311 in which a plurality of openings 311h are formed, a third side wall portion 331 protruding upward from the second bottom portion 311, and a second bottom portion 311 ), and may further include a locking jaw 371 protruding from the lower surface of the second bottom portion 311. The second bottom portion 311, the third side wall portion 331, the cutout 351, and/or the locking jaw 371 may be integrally formed without physical boundaries.

The second bottom part 311 at the bottom of the cutting unit 301, the third side wall part 331, the cutting part 351, and the locking jaw 371 may be made of synthetic resin or the like. For example, the cutting unit 301 may be made of a material with lower rigidity than the cap 101 and/or the container body 201 . For a specific example, the cutting unit 301 may be made of a material having elasticity compared to the cap 101 and/or the container body 201 .

The second bottom portion 311 may have a substantially circular shape when viewed from a plan view. The second bottom part 311 may have a plurality of openings 311h. The openings 311h may have a regular matrix arrangement along the first direction (X) and the second direction (Y), have a circular arrangement, or may be arranged irregularly. In another embodiment, the openings 311h may be implemented in the form of radially arranged slits. In some embodiments, the collection of the plurality of openings 311h may be approximately circular. The second bottom part 311 formed with the opening 311h may function as a filter plate. The size of the opening 311h may be appropriately selected in consideration of the size of the specimen. For example, the length of the opening 311h in the first direction X (or the second direction Y) is about 10 mm or less, or about 5 mm or less, or about 4 mm or less, or about 3 mm or less, or about 2 mm or less, or about 1 mm or less, or about 0.5 mm or less.

The third side wall portion 331 may protrude upward from the second bottom portion 311 . The third side wall portion 331 may have a substantially cylindrical shape with an open top. The outer diameter of the third side wall portion 331 is smaller than the inner diameter of the fastening body portion 121, and the inner diameter of the third side wall portion 331 is slightly smaller than or substantially the same as the outer diameter of the first side wall portion 131. or may be slightly larger. That is, the inner surface of the third side wall portion 331 may be engaged with the flat outer surface of the first side wall portion 131 to form an interference fit coupling that maintains the coupled state by frictional force.

In some embodiments, an inner surface of the third side wall portion 331 may be in a flat state without a screw thread or the like. Through this, an interference fitting (or fitting) may be formed between the first side wall portion 131 of the cap 101 and the third side wall portion 331 of the cutting unit 301 . In addition, through the coupling of the cap 101 and the cutting unit 301, when a user rotates the cap 101 when no external force is applied, the cutting unit 301 also maintains a state coupled with the cap 101 and may be integrally rotated together at least partially.

On the other hand, the coupling between the cap 101 and the cutting unit 301 may be a rotational non-limiting coupling. That is, for example, in a state in which only the cap 101 and the cutting unit 301 are coupled without other components, the cutting unit 301 based on the cap 101 (or the cap 101 based on the cutting unit 301) e) The cap 101 and the cutting unit 301 may not be separated from each other even when rotated by about 90 degrees or more, about 180 degrees or more, or about 270 degrees or more on a plane. In addition, in a state in which the cap 101 and the cutting unit 301 form a coupling, the angle of rotation on the plane thereof may be made unlimited to an angle of 360 degrees or more.

On the other hand, the cap 101 and the cutting unit 301 may form a coupling capable of being inserted in the third direction (Z). For example, the cap 101 and the cutting unit 301 may be configured to be inserted in the third direction (Z) without rotation. That is, the degree of insertion of the cap 101 and the cutting unit 301 may be adjusted. In other words, even when the cap 101 is relatively slightly inserted into the cutting unit 301, the cap 101 and the cutting unit 301 form a coupling relationship, and the cap 101 is relatively small to the cutting unit 301. Even when many are inserted into the cap 101 and the cutting unit 301 can form a coupling relationship.

Through this, only by applying an external force in the third direction (Z), the insertion depth of the cap 101 into the cutting unit 301 can be adjusted, and further, the distance between the cutting portion 351 and the sealing sheet 150 to be described later distance can be adjusted. In some embodiments, the protruding length of the third side wall portion 331 in the third direction Z is smaller than the protruding length of the first side wall portion 131 in the third direction Z, and the first side wall portion ( When the cutting unit 131 is fully inserted into the cutting unit 301, the lower end of the first side wall part 131 may come into contact with the upper surface of the second bottom part 311.

The cutout 351 may include a first cutout 351a and a second cutout 351b. When viewed from a plan view, the first cutout 351a may be disposed to at least partially surround the second cutout 351b. The protruding heights of the first cutout 351a and the second cutout 351b in the third direction (Z) may be smaller than the protruding height of the third sidewall portion 331 in the third direction (Z). That is, the height formed by the cutout 351 may be smaller than the height formed by the third side wall portion 331 .

Specifically, the first cutout 351a may form one or more tips (or tips). 4 and the like illustrate a case in which four first cutouts 351a are provided, but the present invention is not limited thereto, and in another embodiment, only one first cutout 351a may be provided. The first cutout 351a may cut the sealing sheet 150 using the tip. Unlike what is represented in the figure, one first cutout 351a may have a plurality of tips in the form of teeth or sawtooths instead of a single tip.

In addition, each of the plurality of first cutouts 351a having a predetermined height may function like a barrier rib. As will be described later, the plurality of first cutouts 351a may be arranged in a substantially circular shape and may be spaced apart from each other. Through the separation space between the first cutouts 351a, the liquid material, for example, the first liquid F may move outside or inside the circularly arranged first cutouts 351a.

Each of the plurality of first cutouts 351a has an outer surface and an inner surface, and the outer and inner surfaces may each form a curved surface. In addition, the plurality of first cutout portions 351a may have substantially the same shape as each other, and the plurality of first cutout portions 351a may be circularly arranged based on a virtual center. That is, the plurality of first cutouts 351a may be arranged along an edge of an imaginary circle. The virtual center may substantially coincide with the center of the circular second bottom portion 311 . As a non-limiting example, any first cutout 351a may have a partial shape of a circular arc when viewed from a plan view.

Unlike what is illustrated in the drawing, in another embodiment, the number of first cutouts 351a may be 2, 3, or 5, but even in this case, the circular arrangement angle between the plurality of first cutouts 351a may be substantially the same. In another embodiment, the plurality of first cutouts 351a are circularly arranged with respect to the imaginary center, and at least some of the first cutouts 351a may have different distances from the imaginary center. .

The outer and inner surfaces of the first incision 351a of the incision unit 301 of the specimen container 10 according to the present embodiment form curved surfaces, and are circularly arranged at a virtual center to cut the sealing sheet 150. may be easier. As will be described later, when the sealing sheet 150 is cut by rotating the cap 101, the center of the circular arrangement of the first cutout 351a may coincide with the center of rotation, and thus the sealing sheet ( 150) can induce a uniform incision. Accordingly, from a flat viewpoint, the first liquid F can be poured substantially uniformly, thereby minimizing an increase in the internal pressure of the specimen container 10 and allowing the user to incise the sealing sheet 150 with minimal force. can do.

In some embodiments, when viewed from a plan view, the plurality of first cutouts 351a may be disposed to surround the opening 311h. That is, the circularly arranged first cutouts 351a may be divided into an outer region and an inner region, and the opening 311h may be located only in the inner region. At the moment when the sealing sheet 150 is cut, the first liquid F in the first space S1 may move toward the second space S2 through the opening 311h.

In this case, since the internal volume of the sample container 10, that is, the volume of the first space S1 and the second space S2 is not large, the first space S1 and the second space S2 are in fluid communication momentarily. In this way, the internal pressure of the inside of the sample container 10 (that is, a region formed by fluid communication between the first space S1 and the second space S2) may increase. This may be because the air in the lower side (second space S2) moves upward while the first liquid F pours down (to the second space S2 side). When the increase in internal pressure is severe, the liquid containing formaldehyde may leak in the form of bubbles through a joint between the cap 101 and the container body 201 . This problem may not be a problem because complete sealing is possible when the coupling between the cap 101 and the container body 201 is an irreversible coupling, but when the coupling between the cap 101 and the container body 201 is a reversible coupling can be a problem Therefore, it is necessary to suppress the increase in the internal pressure of the sample container 10 as much as possible.

In this case, the inventors of the present invention confirmed that the increase in the internal pressure of the container is affected by the uniform permeation of the first liquid (F) and came to complete the present invention. As described above, the first cutout 351a may be configured to pour the first liquid F by cutting the sealing sheet 150 from the bottom to the top. That is, the cutout or opening formed in the sealing sheet 150 is a position corresponding to the first cutout 351a on a plane, or an inner position cut by the second cutout 351b to be described later. Accordingly, from a plan view, the first liquid F is mainly poured through the inner region of the imaginary circle in which the first cutout 351a is arranged.

Accordingly, an increase in the internal pressure of the container may be minimized by forming the opening 311h only in the inner region of the first cutout 351a, that is, in the region in which liquid is expected to pour. In other words, by forming an opening 311h only on the inside where only a relatively small amount of liquid material is poured, without forming an opening on the outside of the first cutout 351a performing the partition function, only a relatively small amount of liquid material is poured, The movement path of air and the movement path of liquid may be concentrated toward the center, and an increase in internal pressure of the container due to an unexpected air flow may be minimized.

In addition, the second liquid (W) located in the first second space (S2) may also contribute to suppressing the increase in internal pressure of the container. The second space (S2) may have a volume sufficient to accommodate a mixed solution of the first liquid (F) and the second liquid (W). In this case, as described above, when the first liquid (F) moves from the upper side to the lower side by gravity, the air may move from the lower side to the upper side. At this time, when the volume of the second space (S2) before the sealing sheet 150 is incised, specifically, the volume of air in the second space (S2) is large, the degree of increase in the internal pressure of the container may be increased. Therefore, this problem can be minimized by the second liquid (W) occupying a predetermined volume in the initial state.

Meanwhile, the second cutout 351b may have a substantially '+' shape when viewed from a plan view. The second cutout 351b may also form one or more tips. For example, the second cutout 351b includes a first portion extending in one direction and a second portion extending in a direction perpendicular to the first portion, and the intersection of the first portion and the second portion is the tip (tip). ) can be formed. The second cutout 351b may cut the sealing sheet 150 using the tip.

Also, the '+' shaped second cutout 351b may come into contact with the circularly arranged first cutout 351a. Accordingly, the circular area where the opening 311h is located (the inner area of the first cutout 351a) may be divided into approximately four areas. By forming the '+'-shaped barrier rib by the second cutout 351b, it is possible to substantially uniform the amount of liquid material passing through each of the four regions, and to minimize the increase in internal pressure. In some embodiments, the second cutout 351b may not overlap the opening 311h in the third direction Z. That is, an opening may not be formed at a location where the second cutout 351b is formed.

The cutting unit 301 of the sample container 10 according to the present embodiment includes not only the circularly arranged first cutout 351a but also the second cutout 351b having a flat side surface to further seal the sealing sheet 150. can be easily incised. As will be described later, cutting of the sealing sheet 150 may be performed by relative rotation between the cutting unit 301 and the cap 101 . In this process, the first cutout 351a is circularly arranged with respect to the center coincident with the rotational axis to induce easy incision, but the second cutout 351b having a flat side uses the tip of the sealing sheet 150. ) and then rotates while pushing the cut sealing sheet 150 by using the side surface. Accordingly, there is an effect that can further reduce the force required to cut the sealing sheet 150.

In some embodiments, the maximum height of the second cutout 351b is smaller than the maximum height of the first cutout 351a, and the moment the sealing sheet 150 and the cutout 351 come close to each other, the second cutout 351b ) The first cutout 351a, which is not, may be configured to contact the sealing sheet 150 first. It is required that the first cutout 351a, which cuts the sealing sheet 150 by using a tip, penetrates the sealing sheet 150 first, rather than the second cutout 351b, which cuts the sealing sheet 150 while pushing back. It can be advantageous in terms of reducing the power to be.

Meanwhile, a plurality of locking protrusions 371 may be disposed on the lower surface of the second bottom portion 311 . The locking jaw 371 may protrude from the lower surface of the second bottom portion 311 . FIG. 5 illustrates a case in which four locking jaws 371 are disposed in a circular arrangement at approximately 90 degrees. As described above, only one locking jaw 371 may be provided, but one of the support portion 251 and the locking jaw 371 may be provided in plurality. The number of locking jaws 371 will be described later in detail.

The locking jaw 371 may be configured to interfere with the support 251 . That is, in a state where the cutting unit 301 is placed on the support part 251, the upper surface of the support part 251 is in contact with the lower surface of the second bottom part 311, and the upper surface of the support part 251 is the locking jaw 371. If , it may be located on the upper side. In other words, the locking jaw 371 and the support portion 251 together may prevent the cutting unit 301 from rotating beyond a predetermined angle with respect to the container body 201 .

In an exemplary embodiment, when four locking protrusions 371 are disposed, rotation of the cutting unit 301 by 90 degrees or more with respect to the container body 201 may be restricted. That is, the cap 101 and the cutting unit 301 are already coupled, and in the process of screwing the cap 101 and the container body 201, as described above, the cap 101 with respect to the container body 201 Even if it is rotated by about 360 degrees, the cutting unit 301 based on the container body 201 may be rotated by about 270 degrees or less. In other words, when rotating the cap 101, the cutting unit 301 rotates together with the cap 101 for an initial predetermined angle, but may be configured not to rotate for a predetermined angle thereafter. The lower limit of the first predetermined angle may be about 20 degrees or more, about 30 degrees or more, or about 40 degrees or more. Also, the upper limit of the initial predetermined angle may be less than about 270 degrees, less than about 180 degrees, and preferably less than about 90 degrees.

In other words, when the cap 101 is rotated 360 degrees with respect to the container body 201, the cap 101 and the cutting unit 301 are coupled for an initial predetermined angle (eg, about 89 degrees). While maintaining the state, the cutting unit 301 may be rotated in conjunction with the cap 101 . Thus, the cutting unit 301 can also rotate about 89 degrees.

On the other hand, during a predetermined angle (eg, about 271 degrees) thereafter, only the cap 101 rotates 271 degrees in a relative position with the container body 201, and the cutting unit 301 rotates the locking jaw 371 and the support ( 251) may prevent further rotation.

In other words, when the cap 101 is rotated 360 degrees with respect to the cap 101, the cutting unit 301 interlocks with the cap 101 during the first predetermined angle (about 89 degrees). Thus, in the relative position between the cap 101 and the cutting unit 301, the position of the cutting unit 301 may not change.

On the other hand, during a predetermined angle (about 271 degrees) thereafter, the cutting unit 301 may rotate about 271 degrees with respect to the cap 101 in a relative position with the cap 101 .

The sample container 10 according to the present embodiment may be configured so that the cutting unit 301 rotates less than that while the cap 101 rotates sufficiently for complete sealing. In an exemplary embodiment, the difference between the maximum angle of rotation of the cap 101 with respect to the container body 201 and the tolerance range of the angle of rotation of the cutting unit 301 may be less than 360 degrees.

The maximum rotational angle of the cap 101 may be adjusted through the extension lengths of the first screw thread 121s and the second screw thread 221s. As described above, the maximum rotation angle of the cap 101 means a rotation angle when the first screw thread 121s and the second screw thread 221s are completely screwed.

In addition, the allowable rotation angle range of the cutting unit 301 may be adjusted through the arrangement angle and/or number of the locking jaw 371 and the support part 251 . Specifically, when all of the locking jaws 371 and the supporters 251 are circularly arranged at a uniform angle, the allowable rotation angle range of the cutting unit 301 is between the number of the locking jaws 371 and the number of supporters 251. It can be less than the numerical value of 360 degrees for large numbers. If there are 4 locking jaws and 4 support units, 4 locking jaws and 1 support unit, or 1 locking jaw and 4 support units, the allowable rotation angle range of the cutting unit 301 may be less than 90 degrees. . In another embodiment, when there are three locking jaws and one support part, the allowable rotation angle range of the cutting unit 301 may be less than 120 degrees. In another embodiment, when there are two locking jaws and one support part, the allowable rotation angle range of the cutting unit 301 may be less than 180 degrees.

Accordingly, the sample container 10 according to the present embodiment can reduce the force required to cut the sealing sheet 150. As described above, when the user grips the container body 201 and rotates the cap 101, the cutting unit 301 also rotates the cap 101 during the first predetermined angle (the allowable rotation angle range of the cutting unit 301). ) and rotates (that is, the cutting unit 301 does not rotate with respect to the cap 101), but when the rotation angle exceeds the allowable range, the cutting unit 301 rotates with respect to the cap 101. do. Therefore, compared to the case where the cutting unit 301 rotates with respect to the cap 101 from the beginning, rotational inertia can be formed in the cap 101 as in the present invention, so that the sealing sheet 150 can be cut more easily. it gets done

In addition, it is possible to prevent the sealing sheet 150 from being completely cut beyond being cut by the cutout 351 . That is, the sealing sheet 150 is completely separated into two or more parts by forming a difference between the maximum rotation angle of the cap 101 with respect to the container body 201 and the allowable rotation angle range of the cutting unit 301 to be less than 360 degrees. It may be configured so that the first liquid (F) can flow out without being cut only partially. If the sealing sheet 150 is partially cut, problems such as the cut portion freed from the lower end of the first side wall portion 131 blocking the opening 311h may occur, which may lead to an increase in the internal pressure of the container. On the other hand, the present invention, but is not limited thereto, has an effect of preventing the sealing sheet 150 from being completely cut through the rotation angle control together with the number, shape, and arrangement of the cutout 351 .

Hereinafter, with further reference to FIGS. 6 to 11 , the structure, coupling relationship, arrangement relationship, and function of the sample container 10 according to the present embodiment will be described in more detail. 6 to 11 are views illustrating a process of using the sample container 10 of FIG. 1 .

Specifically, FIG. 6 is a cross-sectional view showing the initial state of the sample container 10, and FIG. 7 is a cross-sectional view showing the step of injecting the sample SP into the sample container 10. 8 is a cross-sectional view showing a state in which the specimen SP is sealed, and FIG. 9 is a rear perspective view showing the arrangement relationship between the container body 201 and the cutting unit 301 in FIG. 8 . 10 is a cross-sectional view showing a state in which the sealing sheet 150 is cut, and FIG. 11 is a rear perspective view showing the arrangement relationship between the container body 201 and the cutting unit 301 in FIG. 10 .

First, further referring to FIG. 6, the blocking ring 401 is placed on the ring support 221k of the container body 201, the cutting unit 301 is coupled to the lower end of the cap 101, and the cap 101 The cap 101 and the container body 201 are coupled using the first screw thread 121s of the container body 201 and the second screw thread 221s of the container body 201.

As described above, the blocking ring 401 is interposed and coupled between the fastening body 121 of the cap 101 and the ring support 221k, and the first side wall portion 131 of the cap 101 and the cutting unit 301 ) The third side wall portion 331 of the interlocking and force-fitted, the cap 101 and the container body 201 may be screwed together. Also, the first screw thread 121s and the second screw thread 221s may be in a partially coupled state by the blocking ring 401 .

In this embodiment, the lower surface of the second bottom part 311 of the cutting unit 301 may be in contact with the upper surface of the support part 251 of the container body 201 . In addition, the second space S2 of the container body 201 in which the first liquid F (ie, preservative solution) containing formaldehyde is accommodated in the first space S1 and sealed by the cap 101 The second liquid W (eg, physiological saline solution) containing sodium chloride may be in a state in which it is accommodated. In this step, the cutout 351 of the cutting unit 301 (expressing only the second cutout 351b on the cross-sectional view) may be spaced apart from the sealing sheet 150 in the third direction (Z).

In another embodiment, the cutting unit 301 may be placed on the support 251 without being coupled to the lower end of the cap 101 . In this case, as will be described later, the cap 101 and the cutting unit 301 may be fitted and coupled in the process of rotating and moving the cap 101 downward. In another embodiment, the cutting unit 301 may be coupled to the lower end of the cap 101 and spaced apart from the support 251 in the third direction (Z). In this case, as will be described later, the cutting unit 301 may come into contact with the support part 251 while the cap 101 is rotated to move the cap 101 and the cutting unit 301 downward.

Next, further referring to FIG. 7 , the screw connection between the cap 101 and the container body 201 is loosened, and the sample SP is introduced into the open second space S2 of the container body 201 . The specimen (SP) may be human cells, tissues, sputum, mouthwash, etc., but the present invention is not limited thereto. As described above, since the second liquid (W) is already accommodated in the second space (S2), it may be easy to inject the specimen (SP) using biopsy forceps or the like.

In this step, the cutting unit 301 is still coupled to the cap 101, and the blocking ring 401 may be placed on the ring support 221k.

Next, further referring to FIGS. 8 and 9 , the blocking ring 401 is removed and the cap 101 and the container body 201 are partially coupled. In this step, the coupling may be screw-tight coupling due to rotation of the first screw thread 121s and the second screw thread 221s. In addition, the sample SP is accommodated and stored in the second space S2 of the container body 201 sealed by the cap 101 and can be completely isolated from the outside.

Specifically, in the process of partially coupling the first screw thread 121s and the second screw thread 221s, that is, in the process of rotating the cap 101 relative to the container body 201, the cutting unit 301 is the cap ( 101) and can be integrated and moved. In other words, the separation distance between the sealing sheet 150 and the cutting portion 351 does not substantially change, the cap 101 and the cutting unit 301 are moved downward together, and the gap between the cap 101 and the cutting unit 301 moves downward. There may be no relative rotation. In addition, as shown in FIG. 9, the locking jaw 371 of the cutting unit 301 and the support 251 of the container body 201 are initially spaced apart, then the cap 101 and the cutting unit 301 rotate. Accordingly, the locking jaw 371 and the support 251 may gradually come closer.

Next, further referring to FIGS. 10 and 11 , the cap 101 and the container body 201 are completely coupled. In this step, the coupling may be screw-tight coupling due to rotation of the first screw thread 121s and the second screw thread 221s.

Specifically, in the process of completely coupling the first screw thread 121s and the second screw thread 221s, that is, in the process of further rotating the cap 101 relative to the container body 201, the cutting unit 301 and the cap ( 101) may vary in their relative position and rotation. In other words, while the cap 101 gradually moves downward through screw fastening, the lower surface of the cutting unit 301 comes into contact with the support 251 so that downward movement may be prevented. Accordingly, the separation distance between the sealing sheet 150 and the cutout 351 gradually becomes closer, and then the cutout 351 penetrates the sealing sheet 150 and partially cuts it. In addition, as shown in FIG. 11, the cutting unit 301 does not rotate with respect to the container body 201 due to interference between the holding jaw 371 of the cutting unit 301 and the support part 251 of the container body 201. may not be In other words, the cap 101 and the cutting unit 301 rotate relative to each other, and through this, the force required for cutting the sealing sheet 150 can be reduced.

As the sealing sheet 150 is cut, the first space (S1) and the second space (S2) are in fluid communication, and the first liquid (F) contained in the first space (S1) is of the cutting unit (301). It may pour into the second space S2 through the opening 311h. The first liquid (F) and the second liquid (W) are mixed with each other to form a mixed liquid (FW), and the specimen (SP) may be fixed or preserved by the mixed liquid (FW). The concentration of formaldehyde in the mixed solution (FW) is about 6.0% (v/v) to 15.0% (v/v), or about 7.0% (v/v) to 14.0% (v/v), or about 8.0% ( v/v) to 13.0% (v/v), or about 8.0% (v/v) to 12.0% (v/v).

The sample container 10 according to the present embodiment accommodates different liquids in the first space S1 and the second space S2 that are separated from each other, thereby reducing the frequency and time that workers are exposed to harmful substances such as formaldehyde. can be minimized. In addition, by configuring the rotational relationship between the cap 101, the cutting unit 301, and the container body 201 within a specific range, it is possible to minimize the force required for cutting the sealing sheet 150 and increase the internal pressure inside the container. has the effect of suppressing

Although the above has been described with reference to the embodiments of the present invention, this is only an example and does not limit the present invention, and those skilled in the art to which the present invention belongs will be able to It will be appreciated that various modifications and applications not exemplified above are possible.

Therefore, it should be understood that the scope of the present invention includes modifications, equivalents, or substitutes of the technical ideas exemplified above. For example, each component specifically shown in the embodiment of the present invention can be modified and implemented. And the differences related to these modifications and applications should be construed as being included in the scope of the present invention as defined in the appended claims.

101: cap
111: ceiling
121: fastening body
121s: first thread
131: first side wall portion
150: sealing sheet
201 container body
211: first bottom part
221: second side wall portion
221k: ring support
221s: second thread
251: support
301: cutting unit
311: second bottom part
311h: opening
331: third side wall portion
351: incision
401: blocking ring
S1: first space
S2: second space
F: first liquid
W: second liquid

Claims (10)

A container body including one or more support members disposed in an inner space surrounded by side wall portions of the body;
a cap coupled to an upper portion of the container body and containing a preservation solution sealed therein; and
A cutting unit including a bottom portion, an incision portion protruding upward from the bottom portion, and one or more locking jaws protruding downward from the bottom portion and coupled to the lower portion of the cap,
When the cap is rotated at a predetermined angle or more relative to the container body,
Rotation of the cutting unit with respect to the container body is limited due to lateral interference between the support portion of the container body and the locking jaw of the cutting unit, and the cap is configured to continuously rotate with respect to the container body. According to claim 1,
In an initial state, a sample container further comprising a solution containing sodium chloride (NaCl) disposed in the inner space of the container body. According to claim 1,
When the rotation of the cutting unit is restricted by rotating the cap by more than the predetermined angle and the cap rotates,
A specimen container configured to further decrease the separation distance between the cap and the cutting unit as the rotation of the cap further proceeds. According to claim 1,
The cap includes a cap side wall portion having an open bottom, and a sealing sheet disposed at a lower end of the cap side wall portion to seal the preservation solution,
The coupling between the container body and the cap includes a screw fastening coupling,
In a state in which the container body and the cap are partially screwed together, the cutting unit is coupled to the lower portion of the cap, and the sealing sheet and the cutting portion are spaced apart from each other,
A sample container configured such that a lower surface of the bottom portion of the cutting unit comes into contact with an upper surface of the support portion of the container body. According to claim 1,
The cap includes a cap side wall portion having an open bottom, and a sealing sheet disposed at a lower end of the cap side wall portion to seal the preservation solution,
The coupling between the container body and the cap includes a screw fastening coupling,
In a state in which the container body and the cap are partially screwed together, the cutting unit is coupled to the lower portion of the cap, and the sealing sheet and the cutting portion are spaced apart from each other,
A specimen container wherein a lower surface of the locking jaw of the cutting unit is positioned lower than an upper surface of the support part of the container body. According to claim 1,
In rotating the cap relative to the container body,
A specimen container configured to rotate the mutually coupled cap and the cutting unit together in a rotation process up to a certain first angle range less than the predetermined angle. According to claim 1,
The bottom of the cutting unit has a plurality of openings,
The incision of the incision unit,
A first cutout having a shape surrounding the opening, and
A second cutout dividing a space surrounded by the first cutout into a plurality of regions;
The maximum height of the first incision is greater than the maximum height of the second incision,
The specimen container, wherein the opening is located only in the space surrounded by the first cutout and is not provided outside the space surrounded by the first cutout. According to claim 1,
Further comprising a blocking ring disposed to be sandwiched between the cap and the container body,
The length of the blocking ring in the vertical direction is
A sample container that is larger than the protruding height of the incision. According to claim 2,
A sample container wherein the sodium chloride concentration of the sodium chloride solution is 0.1% (v/v) to 1.0% (v/v). According to claim 1,
Further comprising a blocking ring disposed to be inserted between the cap and the container body in an initial state in which the cap and the container body are coupled,
The container body further includes a ring support disposed on an outer circumferential surface of the side wall portion of the body, and the cap further includes a ceiling portion and a fastening body portion protruding downward from the ceiling portion and having a thread formed on an inner surface thereof,
The blocking ring is sandwiched between the lower surface of the fastening body and the upper surface of the ring support,
The length of the blocking ring in the vertical direction is
A specimen container greater than the vertical separation distance between the bottom of the cutting unit and the bottom of the cap in the initial state.

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