KR102537686B1 - D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도 - Google Patents

D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도 Download PDF

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KR102537686B1
KR102537686B1 KR1020227029414A KR20227029414A KR102537686B1 KR 102537686 B1 KR102537686 B1 KR 102537686B1 KR 1020227029414 A KR1020227029414 A KR 1020227029414A KR 20227029414 A KR20227029414 A KR 20227029414A KR 102537686 B1 KR102537686 B1 KR 102537686B1
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pharmaceutical composition
schizophrenia
daao
disease
drugs
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KR20220123738A (ko
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위펑 제인 쳉
위-리 리우
충-밍 순
하이-우 후
치-민 리우
웬-성 라이
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위펑 제인 쳉
내셔널 타이완 유니버시티
내셔날 헬스 리서치 인스티튜트
내셔널 양 밍 치아오 퉁 유니버시티
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • C12Y104/03003—D-Amino-acid oxidase (1.4.3.3)
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    • G01N2333/90633—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general
    • G01N2333/90638—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general with a definite EC number (1.4.3.-)
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KR1020227029414A 2014-04-30 2015-04-30 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도 Active KR102537686B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461986480P 2014-04-30 2014-04-30
US61/986,480 2014-04-30
PCT/US2015/028385 WO2015168346A1 (en) 2014-04-30 2015-04-30 Use of known compounds as d-amino acid oxidase inhibitors
KR1020167032409A KR20160147868A (ko) 2014-04-30 2015-04-30 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도

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KR20220123738A KR20220123738A (ko) 2022-09-08
KR102537686B1 true KR102537686B1 (ko) 2023-05-30

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KR1020167032409A Ceased KR20160147868A (ko) 2014-04-30 2015-04-30 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도

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US (2) US9868975B2 (https=)
EP (2) EP3498275B1 (https=)
JP (2) JP2017524143A (https=)
KR (2) KR102537686B1 (https=)
CN (2) CN112773798B (https=)
AU (1) AU2015253099B2 (https=)
CA (1) CA2946153C (https=)
DK (1) DK3137658T3 (https=)
ES (2) ES2951736T3 (https=)
IL (1) IL248567B (https=)
MX (2) MX2016011551A (https=)
PT (1) PT3137658T (https=)
SG (2) SG11201607166XA (https=)
TW (1) TWI675660B (https=)
WO (1) WO2015168346A1 (https=)

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EP3512840B1 (en) * 2016-09-14 2024-03-06 Yufeng Jane Tseng Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors
CN108143734A (zh) * 2018-02-09 2018-06-12 南京中医药大学 阿莫地喹及其药学上可接受的盐在制备用于治疗阿尔茨海默病的药物中的应用
US20220016099A1 (en) * 2018-12-06 2022-01-20 Trinuero Benzimidazole or benzoxazole derivatives for preventing and treating central nervous system disease, diabetes, and complications thereof
EP3915120A1 (en) * 2019-01-23 2021-12-01 The Regents of the University of Michigan Pharmacogenomic decision support for modulators of the nmda, glycine, and ampa receptors
CN110297839B (zh) * 2019-06-25 2022-04-12 中国人民解放军军事科学院军事医学研究院 药物适应症的查询方法、装置、计算机设备和存储介质
CA3166147A1 (en) * 2021-06-23 2022-12-23 Yoda Pharmaceuticals Inc. Benzimidazole derivatives for treatment and/or prevention of diseases and disorders mediated by nlrp3

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