KR102534900B1

KR102534900B1 - 뇌경색 발증 리스크 예측 방법

Info

Publication number: KR102534900B1
Application number: KR1020190164971A
Authority: KR
Inventors: 마사후미 이하라; 슈헤이 오카자키; 다이스케 가와카미
Original assignee: 고쿠리츠켄큐카이하츠호진 고쿠리츠쥰칸키뵤 겐큐센터; 가부시키가이샤 시마쓰세사쿠쇼
Priority date: 2018-12-13
Filing date: 2019-12-11
Publication date: 2023-05-19
Also published as: KR20200073149A; JP2023021471A; JP2020092660A; KR102613599B1; KR20210113145A; US20200190590A1

Abstract

(과제) 뇌경색의 발증 확실도를 예측하는 방법을 제공한다.
(해결 수단) 뇌경색 미발증의 피검자 유래의 샘플에 있어서의 RNF213 p.R4810K 유전자 다형의 유무를 검출하는 검출 스텝과, 상기 검출 스텝에 있어서의 상기 RNF213 p.R4810K 유전자 다형의 유무와, 상기 피험자의 성별 정보, 에 기초하여 당해 피험자의 뇌경색 발증 확률이 높은지 여부를 판정하는 판정 스텝, 을 포함하는, 뇌경색 발증 리스크를 예측하는 방법. RNF213 p.R4810K 유전자 다형으로 이루어지는, 뇌경색 발증 리스크를 성별 정보를 이용하여 예측하기 위한 유전자 마커. RNF213 p.R4810K 유전자가 코드하는 폴리펩티드로 이루어지는, 뇌경색 발증 리스크를 성별 정보를 이용하여 예측하기 위한 바이오 마커.

Description

뇌경색 발증 리스크 예측 방법{PREDICTION METHOD FOR RISK OF ISCHEMIC STROKE ONSET}

본 발명은, 뇌경색의 발증 리스크나 발증 시기의 예측, 및 그들의 연구 분야에 속하고, 특히, 뇌경색 발증 리스크 예측 방법, 및 성별 정보를 이용한 뇌경색 발증 리스크 예측 방법에 관한 것이다.

비특허문헌 1 에는, 모야모야병의 감수성 유전자인 RNF213 유전자 다형 (c.14576G＞A, p.R4859K, rs112735431) 은, 모야모야병 뿐만 아니라, 편측 모야모야병이나 아테롬성 동맥 경화의 두개 내 주간 동맥 협착 (두개 내 협착) 과도 유의하게 관련하는 것이 개시되어 있고, 한편, 상기 RNF213 유전자 다형은, 경부 경동맥 협착, 뇌동맥류, 뇌 내출혈과는 유의한 관련은 확인되지 않은 것이 개시되어 있다.

또한, 비특허문헌 1 에 있어서의 RNF213 유전자 다형에 대한 (c.14576 G＞A, p.R4859K, rs112735431) 이라는 표기는, 토호쿠 대학 그룹에 의한 명명에 기초하고 있다. 본 명세서에 있어서는, 교토 대학 그룹에 의한 명명에 기초하여, 동일한 RNF213 유전자 다형을 p.R4810K 다형 (c.14429G＞A, rs112735431) 또는 간단히 p.R4810K 다형이라고 표기한다. 양자는, 아미노산의 세는 방법의 차이에 의한 것으로, 동일한 다형이다.

「RNF213 과 모야모야 증후군 (RNF213 and Moyamoya syndrome)」, 미야와키 사토루, Niche Neuro-Angiology Conference 2016, http : //nnac.umin.jp/nnac/NNAC_2016_files/％E5％AE％AE％E8％84％87％E5％85％88％E7％94％9F.pdf

본 발명의 목적은, 뇌경색의 발증 확실도를 예측하는 방법을 제공하는 것에 있다.

뇌경색은, 아테롬 혈전성 뇌경색 (atherothrombotic brain infarction), 라쿠나 경색 (lacunar infarction), 및, 뇌색전 (embolism) 의 3 종류로 분류된다.

본 발명자들의 검토에 의해, RNF213 p.R4810K 유전자 다형과 아테롬 혈전성 뇌경색 사이에서 유의하게 상관을 갖는 것을 알 수 있었다. 이것으로부터, 뇌경색 미발증의 피검자 유래의 샘플에 있어서의 RNF213 유전자 다형의 유무를 검출함으로써, 당해 피검자의 뇌경색의 발증 리스크나 발증 시기를 예측하는 방법 (혹은 보조적으로 예측하는 방법) 이 제공된다.

본 발명은, 이하의 발명을 포함한다.

(1) 뇌경색 미발증의 피검자 유래의 샘플에 있어서의 RNF213 p.R4810K 유전자 다형의 유무를 검출하는 검출 스텝과,

상기 검출 스텝에 있어서의 상기 RNF213 p.R4810K 유전자 다형의 유무와, 상기 피험자의 성별 정보에 기초하여, 당해 피험자의 뇌경색 발증 확률이 높은지 여부를 판정하는 판정 스텝,

을 포함하는, 뇌경색 미발증의 피검자의 뇌경색 발증 리스크를 예측하는 방법.

(2) 상기 검출 스텝에 있어서, 상기 RNF213 p.R4810K 유전자 다형이 검출된 경우, 상기 판정 스텝에 있어서, 상기 RNF213 p.R4810K 유전자 다형을 가지지 않는 자에 비하여, 당해 피험자는 뇌경색 발증의 리스크가 높은 것으로 판정하는, 상기 (1) 에 기재된 방법.

(3) 상기 검출 스텝에 있어서, 상기 RNF213 p.R4810K 유전자 다형이 검출된 경우, 상기 판정 스텝에 있어서, 당해 피험자의 성별이 여성인 경우에는 남성의 경우에 비하여, 당해 피험자는 뇌경색 발증의 리스크가 보다 높은 것으로 판정하는, 상기 (1) 또는 (2) 에 기재된 방법.

(4) RNF213 p.R4810K 유전자 다형으로 이루어지는, 뇌경색 발증 리스크를 성별 정보를 이용하여 예측하기 위한 유전자 마커.

(5) RNF213 p.R4810K 유전자가 코드하는 폴리펩티드로 이루어지는, 뇌경색 발증 리스크를 성별 정보를 이용하여 예측하기 위한 바이오 마커.

본 발명의 지견에 의해, 뇌경색 미발증의 피검자에 대하여, 조기 단계부터 뇌경색 발증의 예측이나 예방·대책을 실시하는 것이 가능해진다.

도 1 은 실시예 1 에 있어서, 환자 선택 순서의 흐름도를 나타낸다.
도 2 는 실시예 1 에 있어서, RNF213 p.R4810K 다형의 유무에 의한 뇌졸중 발증의 평균 연령에 대한 상자 수염도이다.
도 3 은 실시예 1 에 있어서, 뇌졸중 서브타입 간에 있어서의 RNF213 p.R4810K 다형의 캐리어 빈도의 성별 특이적인 차이의 막대 그래프이다. 좌측의 막대가 남성이고, 우측의 막대가 여성이다.
도 4 는 실시예 2 에 있어서, 환자 선택 순서의 흐름도를 나타낸다.
도 5 는 RNF213 p.R4810K 다형의 보유율을 나타내는 원 그래프로, 왼쪽이 실시예 2 에 있어서의 전체 70 명의 환자에 대한 원 그래프이고, 오른쪽이 기 보고에 의한 일반 집단에 대한 원 그래프이다.
도 6 은 실시예 2 에 있어서, 성별간에서의 RNF213 p.R4810K 다형의 보유율의 차이를 나타내는 원 그래프로, 왼쪽이 남성 (N=44) 에 대한 원 그래프이고, 오른쪽이 여성 (N-26) 에 대한 원 그래프이다.
도 7 은 실시예 2 에 있어서, M1/A1 협착의 유무에 의한 RNF213 p.R4810K 다형의 보유율의 차이를 나타내는 원 그래프로, 왼쪽이 협착 있음 (N=48) 에 대한 원 그래프이고, 오른쪽이 협착 없음 (N=22) 에 대한 원 그래프이다.
도 8 은 실시예 2 에 있어서, RNF213 p.R4810K 다형을 갖는 대표 증례 (표 6 에 있어서의 Case6) 의 화상 데이터이다. (A) 는 MRI 확산 강조 이미지이고, (B) 는 MRA 화상이고, (C)는 뇌경색 발증 5 년 후의 MRA 화상이다.

RNF213 (Ring finger protein 213) (GenBank accession number NM＿001256071.1) 은, 모야모야병의 질환 감수성 유전자로서 최근에 동정된 것으로, 인간 염색체 영역 17q25.3 에 존재한다.

RNF213 p.R4810K 유전자 다형은, 서열 번호 2 로 나타내는 뉴클레오티드 서열에 있어서의 73097 G＞A 의 1 염기 다형 (SNP ; Single Nucleotide Polymorphism) 이다. RNF213 p.R4810K 는, 상기 선행 문헌과 같이 모야모야병 감수성 다형으로서 알려져 있다.

본 발명자들의 연구에 의해, RNF213 p.R4810K 다형이, 대동맥 아테롬성 동맥 경화증에 의한 허혈성 뇌졸중 (즉, 뇌경색) 의 리스크를 증가시키는 것이 판명되었다. 본 명세서 중에서, 허혈성 뇌졸중이란, 뇌경색과 동일한 의미이다.

허혈성 뇌졸중은, 최근의 조기 사망의 하나의 원인으로, 특히 아시아에 있어서의 장해 및 조기 사망의 주요한 원인이지만, 허혈성 뇌졸중과 유전적 상관은 미지인 상태이다. 주로 동아시아에서 확인되는, 뇌혈관 질환인 모야모야병은, RING 핑거 단백질 213 (RNF213) 이라는 감수성 유전자와 관련하고 있고, 그 조절 부전은 마우스의 뇌에 있어서의 뇌관류를 손상시킨다. 본 발명자들은, 따라서, RNF213 은 허혈성 뇌졸중에 있어서 보다 일반적인 역할을 한다고 가설을 세워, 모야모야병의 가장 일반적인 리스크인 RNF213 유전자의 p.R4810K 다형과, 허혈성 뇌졸중 및 그 서브타입의 관련을 조사하였다.

RNF213 p.R4810K 유전자 다형은, 서열 번호 2 로 나타내는 뉴클레오티드 서열에 있어서의 73097 G＞A 의 1 염기 다형 (SNP ; Single Nucleotide Polymorphism) 이고, 뇌경색 발증 리스크를 예측하기 위한, 혹은 예측을 보조하기 위한 유전자 마커가 될 수 있다.

서열 번호 2 는, 미스테린 유전자 및 그 주변 영역의 유전자 [FLJ3520, NPTX1, CARD14, 및 Raptor (KIAA1303)] 를 포함하는 인간 제 17 번 염색체 DNA 의 부분 뉴클레오티드 서열이고, NCBI 에 등록되어 있는 Contig ＃NT010783.15 의 제 43560001 ∼ 43795000 번째의 뉴클레오티드에 상당한다.

서열 번호 2 로 나타내는 뉴클레오티드 서열에는, G 또는 A 인 제73097 위치의 SNP (본 명세서 중 73097 G＞A 라고 약기한다) 이외에도,

T 또는 C 인 제 4766 위치의 SNP (4766 T＞C),

G 또는 A 인 제 120764 위치의 SNP (120764 G＞A),

G 또는 A 인 제 152917 위치의 SNP (152917 G＞A), 및

G 또는 A 인 제 232102 위치의 SNP (232102 G＞A) 도 존재할 수 있다.

또한, 본 명세서에 있어서, SNP 의 위치는, 서열 번호 2 로 나타내는 뉴클레오티드 서열에 있어서의 뉴클레오티드의 위치를 기준으로 기재한다. 예를 들어, 「제 73097 위치의 SNP」 는, 서열 번호 2 로 나타내는 뉴클레오티드 서열에 있어서의 제 73097 위치의 뉴클레오티드에 있어서의 SNP 를 의미한다. 「73097 G＞A」 등이라고 기재하는 경우, 「＞」 의 기호 앞에 메이저 얼릴의 염기 (이 경우 G) 를, 뒤에 마이너 얼릴의 염기 (이 경우 A) 를 기재하고 있다.

또한, 본 명세서에 있어서 뉴클레오티드 서열은, 특별히 언급이 없는 한 DNA 의 서열로서 기재하지만, 폴리뉴클레오티드가 RNA 인 경우에는, 티민 (T) 을 우라실 (U) 로 적절히 바꾸어 읽는 것으로 한다.

본 발명에 있어서, 폴리뉴클레오티드는, 서열 번호 2 로 나타내는 뉴클레오티드 서열이 연속된 부분 서열 또는 그 상보 서열에 더하여, 임의의 부가적 서열을 포함하고 있어도 된다.

본 발명에 있어서, 폴리뉴클레오티드는, 바람직하게는 단리 또는 정제되어 있다.

본 발명의 상기 방법의 검출 공정에서는, 피검자로부터 채취된 생체 시료에 있어서, 73097 G＞A 의 SNP 를 검출한다.

인간의 인종은, 특별히 한정되지 않지만, 바람직하게는 동아시아인 (이스트 아시안/몽골로이드) 이다.

여기서, 인종 (race) 은, 호모·사피엔스종 중의, 특정한 서브그룹으로서 구별 가능한 집단이다. 인종은, 특유하고, 구별 가능한, 유전자의 조합을 갖고, 그 유전자의 조합에 의해 만들어지는 특징 (정신적, 육체적 모두) 에 의해 동정된다. 동일한 인종의 멤버는, 공통적인 유전적 조상을 공유하고, 그 결과, 유사한 유전자 조합을 공유하기 때문에, 분명히 구별할 수 있는 유전적 특징을 공유하고 있다.

예를 들어, 세계의 주요한 인류 집단에 대하여, 23 종류의 유전자 정보에 기초하여, 유전적 근친 관계가 조사되어, 아프리칸 (네그로이드), 코카소이드 (백인), 오세아니안 (오스트랄로이드), 이스트 아시안 (몽골로이드) 및 네이티브 아메리칸의 5 종으로 분류되어 있다.

동아시아인이란, 일본, 조선, 중국, 대만 및 몽골 사람들의 어느 것을 기원으로 가지는 인간이라는 의미이다. 동아시아인은, 바람직하게는, 일본인, 조선인, 또는 중국인이다.

당업자이면, 개인의 신체적 특징, 출신국, 선조의 기원에 관한 정보 등에 기초하여 그 개인의 인종을 용이하게 특정하는 것이 가능하다.

상기 방법에 있어서 사용되는 생체 유래 시료로는, 게놈 DNA 를 채취 가능한 임의의 조직, 세포, 체액 등을 사용할 수 있지만, 입수의 용이성 및 저침습성 등의 관점에서, 모발, 손톱, 피부, 점막, 혈액, 혈장, 혈청, 타액 등이 바람직하게 사용된다.

SNP 의 검출 방법은, 당해 기술 분야에 있어서 주지이다. 예를 들어, RFLP (제한 효소 절단 단편 길이 다형) 법, PCR-SSCP (1 개 사슬 DNA 고차 구조 다형 해석) 법, ASO (Allele Specific Oligonucleotide) 하이브리다이제이션법, 시퀀스법, ARMS (Amplification Refracting Mutation System) 법, 변성 농도 구배 겔 전기 영동 (Denaturing Gradient Gel Electrophoresis) 법, RNAseA 절단법, DOL (Dye-labeled Oligonucleotide Ligation) 법, TaqMan PCR 법, primer extension 법, 인베이더법 등을 사용할 수 있다.

또한, RNF213 p.R4810K 유전자가 코드하는 폴리펩티드는, 서열 번호 1 로 나타내는 아미노산 서열을 포함하는 폴리펩티드 (여기서, 서열 번호 1 로 나타내는 아미노산 서열에 있어서의 제 4810 번의 아르기닌이 리신으로 치환되어 있다) 이고, 뇌경색 발증 리스크를 예측하기 위한 바이오 마커가 될 수 있다.

즉, 상기 서술한 바와 같이, RNF213 p.R4810K 의 SNP 의 변이는, 인간 미스테린의 제 4810 번의 아미노산 치환 (아르기닌 → 리신) 을 수반하기 때문에, 피험자로부터, 미스테린 폴리펩티드를 단리하고, 그 제 4810 번의 아미노산을 동정함으로써, 뇌경색 발증 리스크를 예측하는 것, 혹은 예측하기 위한 보조가 가능해진다.

실시예

이하에 실시예를 나타내고, 본 발명을 구체적으로 설명하지만, 본 발명은 실시예에 제한되는 것은 아니다.

[실시예 1 : 아테롬 혈전성 뇌경색과 RNF213 p.R4810K 다형의 관련]

뇌졸중 사망률은 과거 수십년 사이에 감소하고 있지만 ¹⁾, 뇌졸중은 세계적으로 보아도, 조기 사망의 제 2 주요 원인이고, 신체 장애의 주요 원인이기도 하다 ²⁾. 세계 인구의 31 ％ 를 차지하는 동남아시아 및 동아시아에서는, 뇌졸중이 조기 사망의 주요 원인으로, 뇌졸중의 발생율 및 이환율은 착실하게 증가하고 있다 ^{1, 2)}. 역학적 연구는, 뇌졸중 서브타입의 실질적인 지리적 차이 및 인종적 차이를 시사하고 있다 ^{3, 4)}. 심근 색전증은 서구 제국의 허혈성 뇌졸중의 일반적인 병인학적 서브타입이다 ⁵⁾. 한편, 두개 내 동맥 협착에서 기인하는 대동맥 아테롬성 동맥 경화증은, 대부분의 아시아 제국에 있어서 주된 병인이다 ⁶⁾. 환경 리스크 요인과 유전적 배경의 차이가, 아시아에 있어서의 대동맥 아테롬성 동맥 경화증의 높은 이환율의 주된 이유인 것으로 생각되고 있다. 최근, 대규모의 다조상 게놈 와이드 관련 메타아날리시스에 의해, 뇌졸중 및 뇌졸중 서브타입에 관련하는 32 유전자좌가 동정되었다 ⁷⁾. 이 연구에서는, 약 800 만의 1 염기 다형 (SNPs) 이 검사되었다. 그러나, 이 분석은, 0.01 미만 (＜ 0.01) 의 마이너 얼릴 빈도 (minor-allele frequency ; MAF) 및 허혈성 뇌졸중의 아시아 특이적인 유전적 결정 인자가 미지의 상태인, 영역 특이적인 희소 얼릴을 제외하였다.

17q25.3 상의 링 핑거 단백질 213 유전자 (RNF213) 는, 모야모야병의 감수성 유전자로서 동정되어 있다 ^8,9). 모야모야병 환자의 80 ％ 보다 다수에 대하여 RNF213 p.R4810K 다형 (c.14429 G＞A, rs112735431) 이 검출되었지만, 동아시아의 건강 피험자의 대립 유전자 (얼릴) 캐리어 빈도는 약 2 ％ 였다 ^8,9). RNF213 은, AAA＋ATPase 와 E3 리가아제의 양방으로서 기능하는 591kDa 단백질 ¹²⁾ 을 코드하고, 두개 내의 폐색성 폐색 병변의 발증 및 저하한 뇌혈류에 대한 보상 적응에 관련하고 있다 ^13,14). 최근, 2 개의 개별적인 센터 연구가, 두개 내 내경동맥 협착 또는 근위 중대뇌 동맥 협착을 갖는 동아시아 비모야모야 환자에 있어서의 RNF213 p.R4810K 다형의 높은 빈도 (20 ∼ 25 ％) 를 보고하고 있다 ^10,15). 따라서, 본 발명자들은, 이 유전적 변이가 아시아에 있어서의 전체적인 허혈성 뇌졸중과 관련하고 있을 가능성이 있는 것으로 가설을 세웠다. 여기서는, 일본 국립 순환기병 연구 센터 (National Cerebral and Cardiovascular Center ; NCVC) 의 연구에 참가한 급성 허혈성 뇌졸중 환자를 분석하고, RNF213 p.R4810K 다형과 허혈성 뇌졸중 및 그 서브타입의 관련성을 조사하였다.

(방법)

(연구 디자인과 참가자)

증례 대조 연구에서는, 모든 환자의 광범위한 임상 데이터 및 방사선 데이터를 포함하는 국립 순환기병 연구 센터 (NCVC) 의 병원 베이스의 단일의 집단 (NCVC 바이오 뱅크) 을 사용하였다. 서면에 의한 동의가 모든 시험 참가자로부터 얻어지고, 이 연구는 국립 순환기병 연구 센터 (NCVC) 의 윤리 위원회에 의해 승인되었다.

(연구)

본 연구의 참가자는, 오사카, 칸사이 지구의 뇌졸중 및 심혈관 질환 전문의 600 병상의 제 3 차 센터인 일본 국립 순환기병 연구 센터 (NCVC) 에서 모집되었다. 2012년 6월부터 2017년 5월에 입원하여, NCVC 에서 포괄적 동의서에 서명한 비심원성 뇌색전증 (대동맥 아테롬성 동맥 경화증 (large-artery atherosclerosis), 소혈관 폐색증 (small-vessel occlusion) 등) 의 일본인 환자 383 예를 본 연구에 포함시켰다. 일본의 후생 노동성의 모야모야병 연구 위원회의 기준에 기초하여, 심원성 뇌색전증 cardioembolic stroke, 확정적/아마도 모야모야병이라고 진단된 환자는 제외하였다 ¹⁷⁾. 환자 선택 순서의 흐름도는 도 1 에 상세히 서술되어 있다.

인구 통계학적 데이터, 아테롬 경화성 위험 인자, 방사선학적 소견, 및 병력은, 뇌졸중 환자의 전향 연구로 수집된 데이터베이스 (prospectively-collected database) 로부터 얻어졌다. 뇌졸중 서브타입은, 급성 뇌졸중 치료에 대한 Org 10172 기준 [the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria] 에 따라서 분류되었다 ¹⁸⁾. 뇌혈관 병변은, 자기 공명 영상법 (magnetic resonance imaging ; MRI) 및 MR 혈관 조영 (MR angiography), 또는 CT 및 CT 혈관 조영 (CT angiography) 에 의해 동정되었다. 전부 순환 협착 (anterior circulation stenosis) 은, Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) 의 연구 기준 ¹⁹⁾ 에 따라, 두개 내 내경동맥 (intracranial internal carotid artery), 중대뇌 동맥 (middle cerebral artery) 또는 전대뇌 동맥 (anterior cerebral artery) 에서 50 ％ 를 초과하는 (＞ 50 ％) 의 직경 감소로 정의되었다. 동일하게, 후부 순환 협착 (posterior circulation stenosis) 은, 두개 내, 척주 후, 또는 후대뇌 동맥에 있어서의 상기의 기준에 따라 정의되었다.

대조 피험자는, 2007년부터 2015년 사이에 일본의 칸사이 지구에서 모집되었다. 잠재적 컨트롤 1,027 명 중, 뇌경색 또는 모야모야병의 병력을 가진 16 명의 피험자를 제외하였다. 최종적으로 1,011 명의 컨트롤 피험자가 선택되었다. 정맥 혈액 샘플을 입원시에 수집하고, 분석까지 -80 ℃ 에서 보존하였다. 이전에 기재되어 있는 ⁸⁾ 바와 같이, TaqMan SNP Assays (Applied Biosystems, Foster City, CA) 및 7300/7500 Real-Time PCR System (Applied Biosystems, Foster City, CA) 을 사용하여 p.R4810K 의 유전자형 결정을 실시하였다.

SNP 지노타이핑은, Illumina HumanOmniExpress BeadChip 과 HumanExome BeadChip 의 조합 분석, 또는 Illumina Human OmniExpressExome BeadChip 분석을 사용하여, 일본 이화학 연구소 생명 의과학 연구 센터 (RIKEN Center for Integrative Medical Sciences) 에서 실시하였다. 하플로 타입 페이징 (Haplotype phasing) 및 유전자형 귀속 (genotype imputation) 은, 성공률 및 Hardy-Weinberg 평형 시험을 포함하는 품질 관리 기준에 합격한 유전자형 데이터를 갖는 여과 샘플을 사용하여 실시하였다. 귀속된 대립 유전자의 투여량을 사용하여 게놈 와이드 관련 해석 [genome-wide association study (GWAS)] 을 실시하고, 가법적 유전 모델을 갖는 로지스틱 회귀 모델에 적합시켰다. 본 발명자들은, 공변량으로서, 10 의 주성분, 연령, 성별을 도입하였다. 상세한 것은 상기에 기재되어 있다 ⁷⁾.

(통계 분석 Statistical analysis)

연속 변수는 평균 ± SD 로서 나타내고, 스튜던트의 t 검정 (Student's t-test) 을 사용하여 비교하였다. 카테고리 변수는, 수치와 퍼센티지로서 표현되고, 카이 2 승 검정 (chi-square test) 과 양측 검정의 피셔 정확 검정 (two-tailed Fisher's exact test) 을 적절히 사용하여 비교하였다. 본 발명자들은, RNF213 다형과 허혈성 뇌졸중의 리스크 사이의 관련성을, 호모 접합체의 수가 불충분하기 때문에 본 연구에서 우성 모델이라고 가정하여 시험하였다. 본 발명자들은 또한, 귀속법 (imputation methods) 을 사용한 검증 연구 (replication studies) 와 비교하기 위해서, 메타아날리시스를 위한 로지스틱 가법 모델 (log-additive model) 하에서의 관련성을 조사하였다. 복수의 로지스틱 회귀 모델 (logistic regression model) 을 사용하여, 잠재적인 교락 인자를 동시에 제어한 후, 각 뇌졸중 서브타입에 대하여 오즈비 (OR Ratio) 및 95 ％ 신뢰 구간 (95 ％ CI) 을 계산하였다. 모델에서 고려된 변수는, 연령 (연속), 성별, 고혈압, 지질 이상 혈증, 당뇨병 및 흡연이었다. 모든 분석은, JMP Pro 12.2 소프트웨어 (SAS Institute Inc., Cary, NC) 를 사용하여 실시하였다.

확률치는 양측이고, p ＜ 0.05 는 유의한 것으로 생각되었다. 메타아날리시스는, p ＜ 5 x 10^-8 이 게놈 전체에서 유의한 것으로 생각되는 역분산 고정 효과 모델 (inverse variance fixed effects model) 을 사용하여, Review Manager (RevMan) 5.3 소프트웨어 (The Nordic Cochrane Center, De㎚ark, Copenhagen) 로 실시하였다.

(결과)

본 연구에서는, 특히 비심원성 뇌색전증 뇌졸중 환자가 등록되었다. 상기 포괄적 기준을 만족한 1,775 명의 비심원성 뇌색전증 뇌졸중 환자 중 383 명 (21.6 ％) 이 NCVC 바이오 뱅크에 참가하는 것에 합의하고, 본 연구에서 분석하였다. NCVC 바이오 뱅크의 참가자와 비참가자의 양방의 환자의 특징은 표 1 에 나타나 있다. 또한, 본 연구 참가자의 베이스 라인 특성을 표 1 에 나타낸다.

RNF213 p.R4810K 다형은, 비심원성 뇌색전증 뇌졸중 환자의 5.2 ％ 및 정상 대조자의 2.1 ％ 에서 발견되었다 (조 OR 2.60, 95 ％ CI 1.39-4.85, p = 0.0019). 연령, 성별, 및 아테롬성 동맥 경화증의 위험 인자를 조정한 후, RNF213 p.R4810K 다형과 비심원성 뇌색전증 뇌졸중 (non-cardioembolic) 의 관련은 유의한 채였다 (조정된 OR 3.90, 95 ％ CI 1.62-9.24, p = 0.0026). 대조 피험자와 비교하여, 대동맥 아테롬성 동맥 경화증 (large-artery atherosclerosis) 은, 다형과 유의하게 관련하고 있었다 (조 OR 5.19, 95 ％ CI 2.53-10.64, p = 2.6 x 10^-6, 조정된 OR 11.45, 95 ％ CI 3.46-36.17, p = 0.0001) (표 2).

RNF213 p.R4810K 다형의 유무에 의한 뇌졸중 환자 사이의 비교에 있어서, 뇌졸중 발증의 평균 연령은 비캐리어보다 RNF213 다형에서 11 세 낮았다 (58.1 ± 15.5 세 대 69.1 ± 13.2 세, p = 0.0003) (도 2). 도 2 는, RNF213 p.R4810K 다형의 유무에 의한 뇌졸중 발증의 평균 연령에 대한 상자 수염도이다.

뇌졸중 환자에 있어서, RNF213 다형 캐리어는, 비캐리어보다, 여성 (55.0 ％ 대 27.3 ％, p = 0.011) 을 보다 많이 포함하고, 두개 내 전부 순환 협착 (60.0 ％ 대 27.3 ％, p = 0.004) 및 대동맥 아테롬성 동맥 경화증 (65.0 ％ 대 32.5 ％, p = 0.012) 의 보다 높은 빈도 (frequency) 를 나타냈다. 두개 외 내경동맥 (extracranial internal carotid artery) 이나 후부 순환 협착 (posterior circulation stenosis) 의 발생, 및, 고혈압, 당뇨병, 지질 이상 혈증 및 흡연 발생률 등의 종래의 아테롬성 동맥 경화성 위험 인자는, 다형 캐리어와 비캐리어 사이에서 다르지 않았다. 이상의 결과를 표 3 에 정리하여 나타낸다.

또한, 각 뇌졸중 서브타입에 있어서의 성별에 의해 계층화된 RNF213 p.R4810K 다형의 캐리어 빈도에 대한 상세를 표 4 에 나타낸다. 또한, 도 3 에, 뇌졸중 서브타입간에 있어서의 RNF213 p.R4810K 다형의 캐리어 빈도의 성별 특이적인 차이를 막대 그래프로 나타낸다. 좌측의 막대가 남성이고, 우측의 막대가 여성이다.

표 4 에 나타내는 바와 같이, 남성과 여성의 어느 경우에 있어서도, RNF213 p.R4810K 다형은, 전체 비심원성 뇌색전증 뇌졸중 (all non-cardioembolic) 과, 아테롬성 동맥 경화증 (atherothrombotic) 과 각각에 유의하게 관련하고 있고, 보다 바람직하게는, RNF213 p.R4810K 다형을 갖는 여성과, 전체 비심원성 뇌색전증 뇌졸중 (조정된 OR 9.8, 95 ％ CI 3.1-30.9, p ＜ 0.001), RNF213 p.R4810K 다형과 아테롬성 동맥 경화증 (atherothrombotic) (조정된 OR 58.0, 95 ％ CI 10.3-327.3, p ＜ 0.001) 사이에 각각 유의한 상관을 볼 수 있었다.

이상과 같이, 본 연구에 의해, RNF213 p.R4810K 다형의 캐리어는, 뇌졸중 발증의 평균 연령은 11 세 낮은 것이 분명해지고, RNF213 p.R4810K 다형의 캐리어 빈도는, 급성 비심원성 뇌색전증 뇌졸중 (acute non-cardioembolic stroke) 환자에 있어서, 특히 아테롬 혈전성 뇌경색 (atherothrombotic brain infarction) 의 여성 환자에 있어서, 매우 높은 것이 분명해졌다.

결론으로서, RNF213 p.R4810K 다형은, 비심원성 뇌색전증 뇌졸중 (non-cardioembolic stroke) 의 유전적 리스크 인자이고, 성별 정보와 조합함으로써 아테롬 혈전성 뇌경색 (atherothrombotic brain infarction) 의 보다 바람직한 유전적 리스크 인자라고 할 수 있다.

[실시예 2 : 두개 내 동맥 협착을 수반하는 약년 발증 뇌졸중과 RNF213 p.R4810K 다형의 관련]

RNF213 은 모야모야병의 감수성 유전자로서 동정되고, RNF213 p.R4810K 다형은 일본인의 모야모야병 환자의 90 ％ 이상이 보유한다. RNF213 은, 혈관 내피 기능의 조정이나 혈관 신생에 중요한 역할을 하고 있는 것으로 생각되고 있지만, 모야모야병과 같은 특이적인 혈관 장해를 일으키는 기전에 대해서는 충분히 해명되어 있지 않다. 한편, 최근, 일본을 포함한 아시아의 정상 성인에서도 2 - 3 ％ 에 이 유전자 다형이 확인되고, 모야모야병이라고 진단되어 있지 않은 두개 내 동맥 협착 환자에서는 20 - 25 ％ 가 마찬가지로 이 유전자 다형을 보유하는 것이 보고되어 있다. 모야모야병 이외의 뇌혈관 장해에 있어서도 이 유전자 다형이 리스크 인자가 될 수 있는 것이 시사되고 있다.

본 연구에서는 60 세 미만의 약년성 뇌경색 환자에 있어서의 RNF213 p.R4810K 다형의 보유율을 조사하고, 이 유전자 다형과 약년성 뇌경색의 관련을 분명히 하는 것을 목적으로 하였다. 여기서, 본 명세서에 있어서의 「약년성 뇌경색」 이라는 용어 중, 「약년성」 이란, 일반적으로 연령 만 60 세까지의 (60 세의 생일 전) 을 의미한다.

(연구 디자인과 대상자)

본 연구는 국립 순환기병 연구 센터 (NCVC) 의 바이오 뱅크 등록 환자를 대상으로 한 단일 시설 횡단 연구이다. 두개 내 동맥 협착 (Intracranial Arterial Stenosis) 을 갖고 20 세 이상 60 세 미만의 비심원성 뇌경색 (non-cardioembolic stroke) 혹은 일과성 뇌허혈 발작 (TIA : transient ischemic attacks) 을 발증한 등록 환자 70 명을 모두 대상으로 하였다. 심원성 뇌색전증 (cardioembolic stroke) 및 모야모야병 (moyamoya disease) 이라고 진단된 증례는 제외하였다. 서면에 의한 동의가 모든 대상자로부터 얻어지고, 이 연구는 국립 순환기병 연구 센터 (NCVC) 의 윤리 위원회에 의해 승인되었다.

(선택 기준)

대상자의 선택 기준은 이하와 같다.

[1] 국립 순환기병 연구 센터 (NCVC) 의 바이오 뱅크 사업에 동의한 환자.

[2] 20 세 이상 60 세 미만으로 허혈성 뇌졸중 혹은 일과성 뇌허혈 발작을 발증한 환자.

[3] 이하의 두개 내 동맥의 적어도 1 개 지점에 50 ％ (직경) 이상의 협착 혹은 폐색을 갖는 환자.

두개 내 내경동맥 (ICA ; intracranial internal carotid artery),

중대뇌 동맥 (middle cerebral artery) M1-2 segment,

전대뇌 동맥 (anterior cerebral artery) A1-2 segment,

후대뇌 동맥 (posterior circulation stenosis) P1-2 segment,

뇌저동맥.

(제외 기준)

심원성 뇌색전증의 환자,

모야모야병의 환자.

환자 선택 순서의 흐름도는 도 4 에 상세히 서술되어 있다.

(방법)

뇌경색 병 서브타입은, 급성 뇌졸중 치료에 대한 Org 10172 기준 [the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria] 에 따라 분류되었다.

RNF213 p.R4810K 다형의 유무와, 동맥 경화 위험 인자, 모야모야병의 가족력, 및 두개 내 협착의 특징을 비교하였다.

정맥 혈액 샘플을 DNA 샘플로서 사용하여, DNA 샘플을 익명화한 후에 교토 대학 대학원 환경 위생학 분야에서, TaqMan SNP Assays (Applied Biosystems, Foster City, CA) 및 7300/7500 Real-Time PCR System (Applied Biosystems, Foster City, CA) 를 사용하여 p.R4810K 의 유전자형 결정을 실시하였다.

(통계 분석 Statistical analysis)

연속 변수는 평균 ± SD 로서 나타내고, 스튜던트의 t 검정 (Student's t-test) 을 사용하여 비교하였다. 카테고리 변수는, 수치와 퍼센티지로서 표현되고, 카이 2 승 검정 (chi-square test) 과 양측 검정의 피셔 정확 검정 (two-tailed Fisher's exact test) 을 사용하여 비교하였다. 각 뇌졸중 서브타입에 대하여 오즈비 (OR Ratio) 및 95 ％ 신뢰 구간 (95 ％ CI) 을 계산하였다. 모델에서 고려된 변수는, 연령 (연속), 성별, 고혈압, 지질 이상 혈증, 2 형 당뇨병, 및 흡연 습관이었다. 모든 분석은, JMP version 11.2.0 소프트웨어 (SAS Institute Inc., Cary, NC) 를 사용하여 실시하였다. 확률치는 양측이고, p ＜ 0.05 는 유의한 것으로 생각되었다.

(결과)

전체 70 명의 환자 배경과 RNF213 p.R4810K 다형의 관련을 표 5 에 나타낸다. 표 5 에 있어서, 카테고리 변수는, 환자수 (％) 로 나타낸다. RNF213 p.R4810K 다형 캐리어 환자 17 명의 특징을 표 6 에 나타낸다.

표 6 에 있어서의 표기는 이하를 의미하고 있다.

Bil ; 양측 (bilateral)

Rt ; 우측 (right)

Lt ; 좌측 (left)

UE ; 미확정 병인 (undetermined etiology)

LAA ; 대동맥 아테롬성 동맥 경화증 (large artery atherosclerosis)

도 5 는, RNF213 p.R4810K 다형의 보유율을 나타내는 원 그래프로, 왼쪽이 본 연구의 전체 70 명의 환자에 대한 원 그래프이고, 오른쪽이 기 보고에 의한 일반 집단에 대한 원 그래프이다.

도 6 은, 본 연구에 있어서의 성별간에서의 RNF213 p.R4810K 다형의 보유율의 차이를 나타내는 원 그래프로, 왼쪽이 남성 (N=44) 에 대한 원 그래프이고, 오른쪽이 여성 (N-26) 에 대한 원 그래프이다.

도 7 은, 본 연구에 있어서의 M1/A1 협착의 유무에 의한 RNF213 p.R4810K 다형의 보유율의 차이를 나타내는 원 그래프로, 왼쪽이 협착 있음 (N=48) 에 대한 원 그래프이고, 오른쪽이 협착 없음 (N=22) 에 대한 원 그래프이다.

도 8 은, 본 연구에 있어서의 RNF213 p.R4810K 다형을 갖는 대표 증례 (표 6 에 있어서의 Case6) 의 화상 데이터이다. (A) 는, MRI 확산 강조 이미지로, 왼쪽 중대뇌 동맥 영역에 산재하는 고신호역이 확인된다. (B) 는, MRA 화상으로, 왼쪽 M1segment 에 중등도 협착이 확인된다. (C) 는, 뇌경색 발증 5 년 후의 MRA 화상으로, 왼쪽 M1segment 의 협착 진행이 확인된다.

RNF213 p.R4810K 다형은 17 명 (24 ％) 의 환자에서 확인되고, 여성에게 많았다 (여성 38 ％ vs 남성 16 ％, OR 3.3, 95 ％ CI 1.1-10.2, p = 0.045). 중대뇌 동맥 근위부 (M1) 혹은 전대뇌 동맥 근위부 (A1) 에 협착을 갖는 환자 중 35 ％ 에서 이 유전자 다형을 볼 수 있었다 (OR 25.0, 95 ％ CI 1.4-437.8, p ＜ 0.01). M1/A1 협착을 복수 갖는 환자에서는 56 ％ 가 이 다형을 보유하고 있었다 (OR 5.1, 95 ％ CI 1.2-21.9, p = 0.033).

(고찰)

본 연구는, 전방 순환계의 뇌동맥 협착, 특히 M1 혹은 A1 협착을 갖는 환자에 있어서 RNF213 p.R4810K 다형의 보유율이 높은 것을 나타냈다. 고령자와 비교하여 혈관 리스크가 적은 약년 환자에 있어서 높은 p.R4810K 다형 보유율을 확인하여, p.R4810K 다형이 뇌경색 발증과 관련될 가능성이 있다. 또한, 두개 내 전방·후방 순환, 원위부의 협착까지 대상으로 한 본 연구에 있어서, M1/A1 협착을 갖는 환자에게 많이 본 유전자 다형을 확인하여, 본 유전자 다형과, 두개 내 협착 부위의 관련이 분명해졌다.

(결론)

상기로부터, RNF213 p.R4810K 다형은, 전방 순환계의 뇌동맥 협착, 특히 M1 혹은 A1 협착을 수반하는 약년 발증 비심원성 뇌경색 환자와 상관을 갖는 것을 알 수 있다.

(참조 문헌)

1) Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, O'Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CMMM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C, Global Burden of Diseases, Injuries and RFS 2010 (GBD 2010) and the GSEG. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383:245-254.

2) GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1459-1544.

3) Bang OY. Considerations when subtyping ischemic stroke in Asian patients. J Clin Neurol. 2016;12:129-136.

4) Gulli G, Rutten-Jacobs LCA, Kalra L, Rudd AG, Wolfe CDA, Markus HS. Differences in the distribution of stroke subtypes in a UK black stroke population - final results from the South London Ethnicity and Stroke Study. BMC Med. 2016;14:77.

5) Kolominsky-Rabas PL, Weber M, Gefeller O, Neundoerfer B, Heuschmann PU. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke. 2001;32:2735-2740.

6) Mehndiratta MM, Khan M, Mehndiratta P, Wasay M. Stroke in Asia: geographical variations and temporal trends. J Neurol Neurosurg Psychiatry. 2014;85:1308-1312.

7) Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese A-K, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen W-M, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu F-C, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jimιnez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee J-M, Lemmens R, Leys D, Lewis CM, Lin W-Y, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmδe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018;50:524-537.

8) Liu W, Morito D, Takashima S, Mineharu Y, Kobayashi H, Hitomi T, Hashikata H, Matsuura N, Yamazaki S, Toyoda A, Kikuta K, Takagi Y, Harada KH, Fujiyama A, Herzig R, Krischek B, Zou L, Kim JE, Kitakaze M, Miyamoto S, Nagata K, Hashimoto N, Koizumi A. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One. 2011;6:e22542.

9) Kamada F, Aoki Y, Narisawa A, Abe Y, Komatsuzaki S, Kikuchi A, Kanno J, Niihori T, Ono M, Ishii N, Owada Y, Fujimura M, Mashimo Y, Suzuki Y, Hata A, Tsuchiya S, Tominaga T, Matsubara Y, Kure S. A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. J Hum Genet. 2011;56:34-40.

10) Miyawaki S, Imai H, Takayanagi S, Mukasa A, Nakatomi H, Saito N. Identification of a genetic variant common to moyamoya disease and intracranial major artery stenosis/occlusion. Stroke. 2012;43:3371-3374.

11) Miyatake S, Miyake N, Touho H, Nishimura-Tadaki A, Kondo Y, Okada I, Tsurusaki Y, Doi H, Sakai H, Saitsu H, Shimojima K, Yamamoto T, Higurashi M, Kawahara N, Kawauchi H, Nagasaka K, Okamoto N, Mori T, Koyano S, Kuroiwa Y, Taguri M, Morita S, Matsubara Y, Kure S, Matsumoto N. Homozygous c.14576G>A variant of RNF213 predicts early-onset and severe form of moyamoya disease. Neurology. 2012;78:803-810.

12) Morito D, Nishikawa K, Hoseki J, Kitamura A, Kotani Y, Kiso K, Kinjo M, Fujiyoshi Y, Nagata K. Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state. Sci Rep. 2014;4:4442.

13) Koizumi A, Kobayashi H, Hitomi T, Harada KH, Habu T, Youssefian S. A new horizon of moyamoya disease and associated health risks explored through RNF213. Environ Health Prev Med. 2016;21:55-70.

14) Morimoto T, Enmi J, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A. Dysregulation of RNF213 promotes cerebral hypoperfusion. Sci Rep. 2018;8:3607.

15) Bang OY, Chung J-W, Cha J, Lee MJ, Yeon JY, Ki C-S, Jeon P, Kim J-S, Hong SC. A Polymorphism in RNF213 Is a Susceptibility Gene for Intracranial Atherosclerosis. PLoS One. 2016;11:e0156607.

16) O'Donnell M, Xavier D, Diener C, Sacco R, Lisheng L, Zhang H, Pias P, Truelsen T, Chin SL, Rangarajan S, Devilliers L, Damasceno A, Mondo C, Lanas F, Avezum A, Diaz R, Varigos J, Hankey G, Teal P, Kapral M, Ryglewicz D, Czlonkowska A, Skowronska M, Lopez-Jaramillo P, Dans T, Langhorne P, Yusuf S, INTERSTROKE investigators. Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke. Neuroepidemiology. 2010;35:36-44.

17) Fukui M. Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis ("moyamoya" disease). Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare, Japan. Clin Neurol Neurosurg. 1997;99 Suppl 2:S238-240.

18) Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.

19) Chimowitz MI, Kokkinos J, Strong J, Brown MB, Levine SR, Silliman S, Pessin MS, Weichel E, Sila CA, Furlan AJ. The Warfarin-Aspirin Symptomatic Intracranial

Disease Study. Neurology. 1995;45:1488-1493.

20) Kim BJ, Kim JS. Ischemic stroke subtype classification: an Asian viewpoint. J stroke. 2014;16:8-17.

21) Park MG, Shin JH, Lee SW, Park HR, Park KP. RNF213 rs112735431 polymorphism in intracranial artery steno-occlusive disease and moyamoya disease in Koreans. J Neurol Sci. 2017;375:331-334.

22) Miyawaki S, Imai H, Shimizu M, Yagi S, Ono H, Mukasa A, Nakatomi H, Shimizu T, Saito N. Genetic variant RNF213 c.14576G>A in various phenotypes of intracranial major artery stenosis/occlusion. Stroke. 2013;44:2894-2897.

23) Kuroda S, Houkin K. Moyamoya disease: current concepts and future perspectives. Lancet Neurol. 2008;7:1056-1066.

24) Kuriyama S, Kusaka Y, Fujimura M, Wakai K, Tamakoshi A, Hashimoto S, Tsuji I, Inaba Y, Yoshimoto T. Prevalence and clinicoepidemiological features of moyamoya disease in Japan: findings from a nationwide epidemiological survey. Stroke. 2008;39:42-47.

25) Roy-O'Reilly M, McCullough LD. Sex differences in stroke: the contribution of coagulation. Exp Neurol. 2014;259:16-27.

26) Williams JE, Chimowitz MI, Cotsonis GA, Lynn MJ, Waddy SP, WASID Investigators. Gender differences in outcomes among patients with symptomatic intracranial arterial stenosis. Stroke. 2007;38:2055-2062.

27) Liu W, Senevirathna STMLD, Hitomi T, Kobayashi H, Roder C, Herzig R, Kraemer M, Voormolen MHJ, Cahovα P, Krischek B, Koizumi A. Genomewide association study identifies no major founder variant in Caucasian moyamoya disease. J Genet. 2013;92:605-609.

SEQUENCE LISTING <110> National Cerebral and Cardiovascular Center SHIMADZU CORPORATION <120> Prediction Method for Risk of Ischemic Stroke Onset <130> SP20180512 <150> JP2018-233549 <151> 2018-12-13 <160> 2 <210> 1 <211> 5207 <212> PRT <213> Homo sapiens <400> 1 Met Glu Cys Pro Ser Cys Gln His Val Ser Lys Glu Glu Thr Pro Lys 1 5 10 15 Phe Cys Ser Gln Cys Gly Glu Arg Leu Pro Pro Ala Ala Pro Ile Ala 20 25 30 Asp Ser Glu Asn Asn Asn Ser Thr Met Ala Ser Ala Ser Glu Gly Glu 35 40 45 Met Glu Cys Gly Gln Glu Leu Lys Glu Glu Gly Gly Pro Cys Leu Phe 50 55 60 Pro Gly Ser Asp Ser Trp Gln Glu Asn Pro Glu Glu Pro Cys Ser Lys 65 70 75 80 Ala Ser Trp Thr Val Gln Glu Ser Lys Lys Lys Lys Arg Lys Lys Lys 85 90 95 Lys Lys Gly Asn Lys Ser Ala Ser Ser Glu Leu Ala Ser Leu Pro Leu 100 105 110 Ser Pro Ala Ser Pro Cys His Leu Thr Leu Leu Ser Asn Pro Trp Pro 115 120 125 Gln Asp Thr Ala Leu Pro His Ser Gln Ala Gln Gln Ser Gly Pro Thr 130 135 140 Gly Gln Pro Ser Gln Pro Pro Gly Thr Ala Thr Thr Pro Leu Glu Gly 145 150 155 160 Asp Gly Leu Ser Ala Pro Thr Glu Val Gly Asp Ser Pro Leu Gln Ala 165 170 175 Gln Ala Leu Gly Glu Ala Gly Val Ala Thr Gly Ser Glu Ala Gln Ser 180 185 190 Ser Pro Gln Phe Gln Asp His Thr Glu Gly Glu Asp Gln Asp Ala Ser 195 200 205 Ile Pro Ser Gly Gly Arg Gly Leu Ser Gln Glu Gly Thr Gly Pro Pro 210 215 220 Thr Ser Ala Gly Glu Gly His Ser Arg Thr Glu Asp Ala Ala Gln Glu 225 230 235 240 Leu Leu Leu Pro Glu Ser Lys Gly Gly Ser Ser Glu Pro Gly Thr Glu 245 250 255 Leu Gln Thr Thr Glu Gln Gln Ala Gly Ala Ser Ala Ser Met Ala Val 260 265 270 Asp Ala Val Ala Glu Pro Ala Asn Ala Val Lys Gly Ala Gly Lys Glu 275 280 285 Met Lys Glu Lys Thr Gln Arg Met Lys Gln Pro Pro Ala Thr Thr Pro 290 295 300 Pro Phe Lys Thr His Cys Gln Glu Ala Glu Thr Lys Thr Lys Asp Glu 305 310 315 320 Met Ala Ala Ala Glu Glu Lys Val Gly Lys Asn Glu Gln Gly Glu Pro 325 330 335 Glu Asp Leu Lys Lys Pro Glu Gly Lys Asn Arg Ser Ala Ala Ala Val 340 345 350 Lys Asn Glu Lys Glu Gln Lys Asn Gln Glu Ala Asp Val Gln Glu Val 355 360 365 Lys Ala Ser Thr Leu Ser Pro Gly Gly Gly Val Thr Val Phe Phe His 370 375 380 Ala Ile Ile Ser Leu His Phe Pro Phe Asn Pro Asp Leu His Lys Val 385 390 395 400 Phe Ile Arg Gly Gly Glu Glu Phe Gly Glu Ser Lys Trp Asp Ser Asn 405 410 415 Ile Cys Glu Leu His Tyr Thr Arg Asp Leu Gly His Asp Arg Val Leu 420 425 430 Val Glu Gly Ile Val Cys Ile Ser Lys Lys His Leu Asp Lys Tyr Ile 435 440 445 Pro Tyr Lys Tyr Val Ile Tyr Asn Gly Glu Ser Phe Glu Tyr Glu Phe 450 455 460 Ile Tyr Lys His Gln Gln Lys Lys Gly Glu Tyr Val Asn Arg Cys Leu 465 470 475 480 Phe Ile Lys Ser Ser Leu Leu Gly Ser Gly Asp Trp His Gln Tyr Tyr 485 490 495 Asp Ile Val Tyr Met Lys Pro His Gly Arg Leu Gln Lys Val Met Asn 500 505 510 His Ile Thr Asp Gly Pro Arg Lys Asp Leu Val Lys Gly Lys Gln Ile 515 520 525 Ala Ala Ala Leu Met Leu Asp Ser Thr Phe Ser Ile Leu Gln Thr Trp 530 535 540 Asp Thr Ile Asn Leu Asn Ser Phe Phe Thr Gln Phe Glu Gln Phe Cys 545 550 555 560 Phe Val Leu Gln Gln Pro Met Ile Tyr Glu Gly Gln Ala Gln Leu Trp 565 570 575 Thr Asp Leu Gln Tyr Arg Glu Lys Glu Val Lys Arg Tyr Leu Trp Gln 580 585 590 His Leu Lys Lys His Val Val Pro Leu Pro Asp Gly Lys Ser Thr Asp 595 600 605 Phe Leu Pro Val Asp Cys Pro Val Arg Ser Lys Leu Lys Thr Gly Leu 610 615 620 Ile Val Leu Phe Val Val Glu Lys Ile Glu Leu Leu Leu Glu Gly Ser 625 630 635 640 Leu Asp Trp Leu Cys His Leu Leu Thr Ser Asp Ala Ser Ser Pro Asp 645 650 655 Glu Phe His Arg Asp Leu Ser His Ile Leu Gly Ile Pro Gln Ser Trp 660 665 670 Arg Leu Tyr Leu Val Asn Leu Cys Gln Arg Cys Met Asp Thr Arg Thr 675 680 685 Tyr Thr Trp Leu Gly Ala Leu Pro Val Leu His Cys Cys Met Glu Leu 690 695 700 Ala Pro Arg His Lys Asp Ala Trp Arg Gln Pro Glu Asp Thr Trp Ala 705 710 715 720 Ala Leu Glu Gly Leu Ser Phe Ser Pro Phe Arg Glu Gln Met Leu Asp 725 730 735 Thr Ser Ser Leu Leu Gln Phe Met Arg Glu Lys Gln His Leu Leu Ser 740 745 750 Ile Asp Glu Pro Leu Phe Arg Ser Trp Phe Ser Leu Leu Pro Leu Ser 755 760 765 His Leu Val Met Tyr Met Glu Asn Phe Ile Glu His Leu Gly Arg Phe 770 775 780 Pro Ala His Ile Leu Asp Cys Leu Ser Gly Ile Tyr Tyr Arg Leu Pro 785 790 795 800 Gly Leu Glu Gln Val Leu Asn Thr Gln Asp Val Gln Asp Val Gln Asn 805 810 815 Val Gln Asn Ile Leu Glu Met Leu Leu Arg Leu Leu Asp Thr Tyr Arg 820 825 830 Asp Lys Ile Pro Glu Glu Ala Leu Ser Pro Ser Tyr Leu Thr Val Cys 835 840 845 Leu Lys Leu His Glu Ala Ile Cys Ser Ser Thr Lys Leu Leu Lys Phe 850 855 860 Tyr Glu Leu Pro Ala Leu Ser Ala Glu Ile Val Cys Arg Met Ile Arg 865 870 875 880 Leu Leu Ser Leu Val Asp Ser Ala Gly Gln Arg Asp Glu Thr Gly Asn 885 890 895 Asn Ser Val Gln Thr Val Phe Gln Gly Thr Leu Ala Ala Thr Lys Arg 900 905 910 Trp Leu Arg Glu Val Phe Thr Lys Asn Met Leu Thr Ser Ser Gly Ala 915 920 925 Ser Phe Thr Tyr Val Lys Glu Ile Glu Val Trp Arg Arg Leu Val Glu 930 935 940 Ile Gln Phe Pro Ala Glu His Gly Trp Lys Glu Ser Leu Leu Gly Asp 945 950 955 960 Met Glu Trp Arg Leu Thr Lys Glu Glu Pro Leu Ser Gln Ile Thr Ala 965 970 975 Tyr Cys Asn Ser Cys Trp Asp Thr Lys Gly Leu Glu Asp Ser Val Ala 980 985 990 Lys Thr Phe Glu Lys Cys Ile Ile Glu Ala Val Ser Ser Ala Cys Gln 995 1000 1005 Ser Gln Thr Ser Ile Leu Gln Gly Phe Ser Tyr Ser Asp Leu Arg 1010 1015 1020 Lys Phe Gly Ile Val Leu Ser Ala Val Ile Thr Lys Ser Trp Pro 1025 1030 1035 Arg Thr Ala Asp Asn Phe Asp Asp Ile Leu Lys His Leu Leu Thr 1040 1045 1050 Leu Ala Asp Val Lys His Val Phe Arg Leu Cys Gly Thr Asp Glu 1055 1060 1065 Lys Ile Leu Ala Asn Val Thr Glu Asp Ala Lys Arg Leu Ile Ala 1070 1075 1080 Val Ala Asp Ser Val Leu Thr Lys Val Val Gly Asp Leu Leu Ser 1085 1090 1095 Gly Thr Ile Leu Val Gly Gln Leu Glu Leu Ile Ile Lys His Lys 1100 1105 1110 Asn Gln Phe Leu Asp Ile Trp Gln Leu Arg Glu Lys Ser Leu Ser 1115 1120 1125 Pro Gln Asp Glu Gln Cys Ala Val Glu Glu Ala Leu Asp Trp Arg 1130 1135 1140 Arg Glu Glu Leu Leu Leu Leu Lys Lys Glu Lys Arg Cys Val Asp 1145 1150 1155 Ser Leu Leu Lys Met Cys Gly Asn Val Lys His Leu Ile Gln Val 1160 1165 1170 Asp Phe Gly Val Leu Ala Val Arg His Ser Gln Asp Leu Ser Ser 1175 1180 1185 Lys Arg Leu Asn Asp Thr Val Thr Val Arg Leu Ser Thr Ser Ser 1190 1195 1200 Asn Ser Gln Arg Ala Thr His Tyr His Leu Ser Ser Gln Val Gln 1205 1210 1215 Glu Met Ala Gly Lys Ile Asp Leu Leu Arg Asp Ser His Ile Phe 1220 1225 1230 Gln Leu Phe Trp Arg Glu Ala Ala Glu Pro Leu Ser Glu Pro Lys 1235 1240 1245 Glu Asp Gln Glu Ala Ala Glu Leu Leu Ser Glu Pro Glu Glu Glu 1250 1255 1260 Ser Glu Arg His Ile Leu Glu Leu Glu Glu Val Tyr Asp Tyr Leu 1265 1270 1275 Tyr Gln Pro Ser Tyr Arg Lys Phe Ile Lys Leu His Gln Asp Leu 1280 1285 1290 Lys Ser Gly Glu Val Thr Leu Ala Glu Ile Asp Val Ile Phe Lys 1295 1300 1305 Asp Phe Val Asn Lys Tyr Thr Asp Leu Asp Ser Glu Leu Lys Ile 1310 1315 1320 Met Cys Thr Val Asp His Gln Asp Gln Arg Asp Trp Ile Lys Asp 1325 1330 1335 Arg Val Glu Gln Ile Lys Glu Tyr His His Leu His Gln Ala Val 1340 1345 1350 His Ala Ala Lys Val Ile Leu Gln Val Lys Glu Ser Leu Gly Leu 1355 1360 1365 Asn Gly Asp Phe Ser Val Leu Asn Thr Leu Leu Asn Phe Thr Asp 1370 1375 1380 Asn Phe Asp Asp Phe Arg Arg Glu Thr Leu Asp Gln Ile Asn Gln 1385 1390 1395 Glu Leu Ile Gln Ala Lys Lys Leu Leu Gln Asp Ile Ser Glu Ala 1400 1405 1410 Arg Cys Lys Gly Leu Gln Ala Leu Ser Leu Arg Lys Glu Phe Ile 1415 1420 1425 Cys Trp Val Arg Glu Ala Leu Gly Gly Ile Asn Glu Leu Lys Val 1430 1435 1440 Phe Val Asp Leu Ala Ser Ile Ser Ala Gly Glu Asn Asp Ile Asp 1445 1450 1455 Val Asp Arg Val Ala Cys Phe His Asp Ala Val Gln Gly Tyr Ala 1460 1465 1470 Ser Leu Leu Phe Lys Leu Asp Pro Ser Val Asp Phe Ser Ala Phe 1475 1480 1485 Met Lys His Leu Lys Lys Leu Trp Lys Ala Leu Asp Lys Asp Gln 1490 1495 1500 Tyr Leu Pro Arg Lys Leu Cys Asp Ser Ala Arg Asn Leu Glu Trp 1505 1510 1515 Leu Lys Thr Val Asn Glu Ser His Gly Ser Val Glu Arg Ser Ser 1520 1525 1530 Leu Thr Leu Ala Thr Ala Ile Asn Gln Arg Gly Ile Tyr Val Ile 1535 1540 1545 Gln Ala Pro Lys Gly Gly Gln Lys Ile Ser Pro Asp Thr Val Leu 1550 1555 1560 His Leu Ile Leu Pro Glu Ser Pro Gly Ser His Glu Glu Ser Arg 1565 1570 1575 Glu Tyr Ser Leu Glu Glu Val Lys Glu Leu Leu Asn Lys Leu Met 1580 1585 1590 Leu Met Ser Gly Lys Lys Asp Arg Asn Asn Thr Glu Val Glu Arg 1595 1600 1605 Phe Ser Glu Val Phe Cys Ser Val Gln Arg Leu Ser Gln Ala Phe 1610 1615 1620 Ile Asp Leu His Ser Ala Gly Asn Met Leu Phe Arg Thr Trp Ile 1625 1630 1635 Ala Met Ala Tyr Cys Ser Pro Lys Gln Gly Val Ser Leu Gln Met 1640 1645 1650 Asp Phe Gly Leu Asp Leu Val Thr Glu Leu Lys Glu Gly Gly Asp 1655 1660 1665 Val Thr Glu Leu Leu Ala Ala Leu Cys Arg Gln Met Glu His Phe 1670 1675 1680 Leu Asp Ser Trp Lys Arg Phe Val Thr Gln Lys Arg Met Glu His 1685 1690 1695 Phe Tyr Leu Asn Phe Tyr Thr Ala Glu Gln Leu Val Tyr Leu Ser 1700 1705 1710 Thr Glu Leu Arg Lys Gln Pro Pro Ser Asp Ala Ala Leu Thr Met 1715 1720 1725 Leu Ser Phe Ile Lys Ser Asn Cys Thr Leu Arg Asp Val Leu Arg 1730 1735 1740 Ala Ser Val Gly Cys Gly Ser Glu Ala Ala Arg Tyr Arg Met Arg 1745 1750 1755 Arg Val Met Glu Glu Leu Pro Leu Met Leu Leu Ser Glu Phe Ser 1760 1765 1770 Leu Val Asp Lys Leu Arg Ile Ile Met Glu Gln Ser Met Arg Cys 1775 1780 1785 Leu Pro Ala Phe Leu Pro Asp Cys Leu Asp Leu Glu Thr Leu Gly 1790 1795 1800 His Cys Leu Ala His Leu Ala Gly Met Gly Gly Ser Pro Val Glu 1805 1810 1815 Arg Cys Leu Pro Arg Gly Leu Gln Val Gly Gln Pro Asn Leu Val 1820 1825 1830 Val Cys Gly His Ser Glu Val Leu Pro Ala Ala Leu Ala Val Tyr 1835 1840 1845 Met Gln Thr Pro Ser Gln Pro Leu Pro Thr Tyr Asp Glu Val Leu 1850 1855 1860 Leu Cys Thr Pro Ala Thr Thr Phe Glu Glu Val Ala Leu Leu Leu 1865 1870 1875 Arg Arg Cys Leu Thr Leu Gly Ser Leu Gly His Lys Val Tyr Ser 1880 1885 1890 Leu Leu Phe Ala Asp Gln Leu Ser Tyr Glu Val Ala Arg Gln Ala 1895 1900 1905 Glu Glu Leu Phe His Asn Leu Cys Thr Gln Gln His Arg Glu Asp 1910 1915 1920 Tyr Gln Leu Val Met Val Cys Asp Gly Asp Trp Glu His Cys Tyr 1925 1930 1935 Leu Pro Ser Ala Phe Ser Gln His Lys Val Phe Val Thr Pro Gln 1940 1945 1950 Ala Pro Leu Glu Ala Ile Gln Ala Tyr Leu Ala Gly His Tyr Arg 1955 1960 1965 Val Pro Lys Gln Thr Leu Ser Ala Ala Ala Val Phe Asn Asp Arg 1970 1975 1980 Leu Cys Val Gly Ile Val Ala Ser Glu Arg Ala Gly Val Gly Lys 1985 1990 1995 Ser Leu Tyr Val Lys Arg Leu His Asp Lys Met Lys Met Gln Leu 2000 2005 2010 Asn Val Lys Asn Val Pro Leu Lys Thr Ile Arg Leu Ile Asp Pro 2015 2020 2025 Gln Val Asp Glu Ser Arg Val Leu Gly Ala Leu Leu Pro Phe Leu 2030 2035 2040 Asp Ala Gln Tyr Gln Lys Val Pro Val Leu Phe His Leu Asp Val 2045 2050 2055 Thr Ser Ser Val Gln Thr Gly Ile Trp Val Phe Leu Phe Lys Leu 2060 2065 2070 Leu Ile Leu Gln Tyr Leu Met Asp Ile Asn Gly Lys Met Trp Leu 2075 2080 2085 Arg Asn Pro Cys His Leu Tyr Ile Val Glu Ile Leu Glu Arg Arg 2090 2095 2100 Thr Ser Val Pro Ser Arg Ser Ser Ser Ala Leu Arg Thr Arg Val 2105 2110 2115 Pro Gln Phe Ser Phe Leu Asp Ile Phe Pro Lys Val Thr Cys Arg 2120 2125 2130 Pro Pro Lys Glu Val Ile Asp Met Glu Leu Ser Ala Leu Arg Ser 2135 2140 2145 Asp Thr Glu Pro Gly Met Asp Leu Trp Glu Phe Cys Ser Glu Thr 2150 2155 2160 Phe Gln Arg Pro Tyr Gln Tyr Leu Arg Arg Phe Asn Gln Asn Gln 2165 2170 2175 Asp Leu Asp Thr Phe Gln Tyr Gln Glu Gly Ser Val Glu Gly Thr 2180 2185 2190 Pro Glu Glu Cys Leu Gln His Phe Leu Phe His Cys Gly Val Ile 2195 2200 2205 Asn Pro Ser Trp Ser Glu Leu Arg Asn Phe Ala Arg Phe Leu Asn 2210 2215 2220 Tyr Gln Leu Arg Asp Cys Glu Ala Ser Leu Phe Cys Asn Pro Ser 2225 2230 2235 Phe Ile Gly Asp Thr Leu Arg Gly Phe Lys Lys Phe Val Val Thr 2240 2245 2250 Phe Met Ile Phe Met Ala Arg Asp Phe Ala Thr Pro Ser Leu His 2255 2260 2265 Thr Ser Asp Gln Ser Pro Gly Lys His Met Val Thr Met Asp Gly 2270 2275 2280 Val Arg Glu Glu Asp Leu Ala Pro Phe Ser Leu Arg Lys Arg Trp 2285 2290 2295 Glu Ser Glu Pro His Pro Tyr Val Phe Phe Asn Asp Asp His Thr 2300 2305 2310 Thr Met Thr Phe Ile Gly Phe His Leu Gln Pro Asn Ile Asn Gly 2315 2320 2325 Ser Val Asp Ala Ile Ser His Leu Thr Gly Lys Val Ile Lys Arg 2330 2335 2340 Asp Val Met Thr Arg Asp Leu Tyr Gln Gly Leu Leu Leu Gln Arg 2345 2350 2355 Val Pro Phe Asn Val Asp Phe Asp Lys Leu Pro Arg His Lys Lys 2360 2365 2370 Leu Glu Arg Leu Cys Leu Thr Leu Gly Ile Pro Gln Ala Thr Asp 2375 2380 2385 Pro Asp Lys Thr Tyr Glu Leu Thr Thr Asp Asn Met Leu Lys Ile 2390 2395 2400 Leu Ala Ile Glu Met Arg Phe Arg Cys Gly Ile Pro Val Ile Ile 2405 2410 2415 Met Gly Glu Thr Gly Cys Gly Lys Thr Arg Leu Ile Lys Phe Leu 2420 2425 2430 Ser Asp Leu Arg Arg Gly Gly Thr Asn Ala Asp Thr Ile Lys Leu 2435 2440 2445 Val Lys Val His Gly Gly Thr Thr Ala Asp Met Ile Tyr Ser Arg 2450 2455 2460 Val Arg Glu Ala Glu Asn Val Ala Phe Ala Asn Lys Asp Gln His 2465 2470 2475 Gln Leu Asp Thr Ile Leu Phe Phe Asp Glu Ala Asn Thr Thr Glu 2480 2485 2490 Ala Ile Ser Cys Ile Lys Glu Val Leu Cys Asp His Met Val Asp 2495 2500 2505 Gly Gln Pro Leu Ala Glu Asp Ser Gly Leu His Ile Ile Ala Ala 2510 2515 2520 Cys Asn Pro Tyr Arg Lys His Ser Glu Glu Met Ile Cys Arg Leu 2525 2530 2535 Glu Ser Ala Gly Leu Gly Tyr Arg Val Ser Met Glu Glu Thr Ala 2540 2545 2550 Asp Arg Leu Gly Ser Ile Pro Leu Arg Gln Leu Val Tyr Arg Val 2555 2560 2565 His Ala Leu Pro Pro Ser Leu Ile Pro Leu Val Trp Asp Phe Gly 2570 2575 2580 Gln Leu Ser Asp Val Ala Glu Lys Leu Tyr Ile Gln Gln Ile Val 2585 2590 2595 Gln Arg Leu Val Glu Ser Ile Ser Leu Asp Glu Asn Gly Thr Arg 2600 2605 2610 Val Ile Thr Glu Val Leu Cys Ala Ser Gln Gly Phe Met Arg Lys 2615 2620 2625 Thr Glu Asp Glu Cys Ser Phe Val Ser Leu Arg Asp Val Glu Arg 2630 2635 2640 Cys Val Lys Val Phe Arg Trp Phe His Glu His Ser Ala Met Leu 2645 2650 2655 Leu Ala Gln Leu Asn Ala Phe Leu Ser Lys Ser Ser Val Ser Lys 2660 2665 2670 Asn His Thr Glu Arg Asp Pro Val Leu Trp Ser Leu Met Leu Ala 2675 2680 2685 Ile Gly Val Cys Tyr His Ala Ser Leu Glu Lys Lys Asp Ser Tyr 2690 2695 2700 Arg Lys Ala Ile Ala Arg Phe Phe Pro Lys Pro Tyr Asp Asp Ser 2705 2710 2715 Arg Leu Leu Leu Asp Glu Ile Thr Arg Ala Gln Asp Leu Phe Leu 2720 2725 2730 Asp Gly Val Pro Leu Arg Lys Thr Ile Ala Lys Asn Leu Ala Leu 2735 2740 2745 Lys Glu Asn Val Phe Met Met Val Val Cys Ile Glu Leu Lys Ile 2750 2755 2760 Pro Leu Phe Leu Val Gly Lys Pro Gly Ser Ser Lys Ser Leu Ala 2765 2770 2775 Lys Thr Ile Val Ala Asp Ala Met Gln Gly Pro Ala Ala Tyr Ser 2780 2785 2790 Asp Leu Phe Arg Ser Leu Lys Gln Val His Leu Val Ser Phe Gln 2795 2800 2805 Cys Ser Pro His Ser Thr Pro Gln Gly Ile Ile Ser Thr Phe Arg 2810 2815 2820 Gln Cys Ala Arg Phe Gln Gln Gly Lys Asp Leu Gln Gln Tyr Val 2825 2830 2835 Ser Val Val Val Leu Asp Glu Val Gly Leu Ala Glu Asp Ser Pro 2840 2845 2850 Lys Met Pro Leu Lys Thr Leu His Pro Leu Leu Glu Asp Gly Cys 2855 2860 2865 Ile Glu Asp Asp Pro Ala Pro His Lys Lys Val Gly Phe Val Gly 2870 2875 2880 Ile Ser Asn Trp Ala Leu Asp Pro Ala Lys Met Asn Arg Gly Ile 2885 2890 2895 Phe Val Ser Arg Gly Ser Pro Asn Glu Thr Glu Leu Ile Glu Ser 2900 2905 2910 Ala Lys Gly Ile Cys Ser Ser Asp Ile Leu Val Gln Asp Arg Val 2915 2920 2925 Gln Gly Tyr Phe Ala Ser Phe Ala Lys Ala Tyr Glu Thr Val Cys 2930 2935 2940 Lys Arg Gln Asp Lys Glu Phe Phe Gly Leu Arg Asp Tyr Tyr Ser 2945 2950 2955 Leu Ile Lys Met Val Phe Ala Ala Ala Lys Ala Ser Asn Arg Lys 2960 2965 2970 Pro Ser Pro Gln Asp Ile Ala Gln Ala Val Leu Arg Asn Phe Ser 2975 2980 2985 Gly Lys Asp Asp Ile Gln Ala Leu Asp Ile Phe Leu Ala Asn Leu 2990 2995 3000 Pro Glu Ala Lys Cys Ser Glu Glu Val Ser Pro Met Gln Leu Ile 3005 3010 3015 Lys Gln Asn Ile Phe Gly Pro Ser Gln Lys Val Pro Gly Gly Glu 3020 3025 3030 Gln Glu Asp Ala Glu Ser Arg Tyr Leu Leu Val Leu Thr Lys Asn 3035 3040 3045 Tyr Val Ala Leu Gln Ile Leu Gln Gln Thr Phe Phe Glu Gly Asp 3050 3055 3060 Gln Gln Pro Glu Ile Ile Phe Gly Ser Gly Phe Pro Lys Asp Gln 3065 3070 3075 Glu Tyr Thr Gln Leu Cys Arg Asn Ile Asn Arg Val Lys Ile Cys 3080 3085 3090 Met Glu Thr Gly Lys Met Val Leu Leu Leu Asn Leu Gln Asn Leu 3095 3100 3105 Tyr Glu Ser Leu Tyr Asp Ala Leu Asn Gln Tyr Tyr Val His Leu 3110 3115 3120 Gly Gly Gln Lys Tyr Val Asp Leu Gly Leu Gly Thr His Arg Val 3125 3130 3135 Lys Cys Arg Val His Pro Asn Phe Arg Leu Ile Val Ile Glu Glu 3140 3145 3150 Lys Asp Val Ala Tyr Lys His Phe Pro Ile Pro Leu Ile Asn Arg 3155 3160 3165 Leu Glu Lys His Tyr Leu Asp Ile Asn Thr Val Leu Glu Lys Trp 3170 3175 3180 Gln Lys Ser Ile Val Glu Glu Leu Cys Ala Trp Val Glu Lys Phe 3185 3190 3195 Ile Asn Val Lys Ala His His Phe Gln Lys Arg His Lys Tyr Ser 3200 3205 3210 Pro Ser Asp Val Phe Ile Gly Tyr His Ser Asp Ala Cys Ala Ser 3215 3220 3225 Val Val Leu Gln Val Ile Glu Arg Gln Gly Pro Arg Ala Leu Thr 3230 3235 3240 Glu Glu Leu His Gln Lys Val Ser Glu Glu Ala Lys Ser Ile Leu 3245 3250 3255 Leu Asn Cys Ala Thr Pro Asp Ala Val Val Arg Leu Ser Ala Tyr 3260 3265 3270 Ser Leu Gly Gly Phe Ala Ala Glu Trp Leu Ser Gln Glu Tyr Phe 3275 3280 3285 His Arg Gln Arg His Asn Ser Phe Ala Asp Phe Leu Gln Ala His 3290 3295 3300 Leu His Thr Ala Asp Leu Glu Arg His Ala Ile Phe Thr Glu Ile 3305 3310 3315 Thr Thr Phe Ser Arg Leu Leu Thr Ser His Asp Cys Glu Ile Leu 3320 3325 3330 Glu Ser Glu Val Thr Gly Arg Ala Pro Lys Pro Thr Leu Leu Trp 3335 3340 3345 Leu Gln Gln Phe Asp Thr Glu Tyr Ser Phe Leu Lys Glu Val Arg 3350 3355 3360 Asn Cys Leu Thr Asn Thr Ala Lys Cys Lys Ile Leu Ile Phe Gln 3365 3370 3375 Thr Asp Phe Glu Asp Gly Ile Arg Ser Ala Gln Leu Ile Ala Ser 3380 3385 3390 Ala Lys Tyr Ser Val Ile Asn Glu Ile Asn Lys Ile Arg Glu Asn 3395 3400 3405 Glu Asp Arg Ile Phe Val Tyr Phe Ile Thr Lys Leu Ser Arg Val 3410 3415 3420 Gly Arg Gly Thr Ala Tyr Val Gly Phe His Gly Gly Leu Trp Gln 3425 3430 3435 Ser Val His Ile Asp Asp Leu Arg Arg Ser Thr Leu Met Val Ser 3440 3445 3450 Asp Val Thr Arg Leu Gln His Val Thr Ile Ser Gln Leu Phe Ala 3455 3460 3465 Pro Gly Asp Leu Pro Glu Leu Gly Leu Glu His Arg Ala Glu Asp 3470 3475 3480 Gly His Glu Glu Ala Met Glu Thr Glu Ala Ser Thr Ser Gly Glu 3485 3490 3495 Val Ala Glu Val Ala Glu Glu Ala Met Glu Thr Glu Ser Ser Glu 3500 3505 3510 Lys Val Gly Lys Glu Thr Ser Glu Leu Gly Gly Ser Asp Val Ser 3515 3520 3525 Ile Leu Asp Thr Thr Arg Leu Leu Arg Ser Cys Val Gln Ser Ala 3530 3535 3540 Val Gly Met Leu Arg Asp Gln Asn Glu Ser Cys Thr Arg Asn Met 3545 3550 3555 Arg Arg Val Val Leu Leu Leu Gly Leu Leu Asn Glu Asp Asp Ala 3560 3565 3570 Cys His Ala Ser Phe Leu Arg Val Ser Lys Met Arg Leu Ser Val 3575 3580 3585 Phe Leu Lys Lys Gln Glu Glu Ser Gln Phe His Pro Leu Glu Trp 3590 3595 3600 Leu Ala Arg Glu Ala Cys Asn Gln Asp Ala Leu Gln Glu Ala Gly 3605 3610 3615 Thr Phe Arg His Thr Leu Trp Lys Arg Val Gln Gly Ala Val Thr 3620 3625 3630 Pro Leu Leu Ala Ser Met Ile Ser Phe Ile Asp Arg Asp Gly Asn 3635 3640 3645 Leu Glu Leu Leu Thr Arg Pro Asp Thr Pro Pro Trp Ala Arg Asp 3650 3655 3660 Leu Trp Met Phe Ile Phe Ser Asp Thr Met Leu Leu Asn Ile Pro 3665 3670 3675 Leu Val Met Asn Asn Glu Arg His Lys Gly Glu Met Ala Tyr Ile 3680 3685 3690 Val Val Gln Asn His Met Asn Leu Ser Glu Asn Ala Ser Asn Asn 3695 3700 3705 Val Pro Phe Ser Trp Lys Ile Lys Asp Tyr Leu Glu Glu Leu Trp 3710 3715 3720 Val Gln Ala Gln Tyr Ile Thr Asp Ala Glu Gly Leu Pro Lys Lys 3725 3730 3735 Phe Val Asp Ile Phe Gln Gln Thr Pro Leu Gly Arg Phe Leu Ala 3740 3745 3750 Gln Leu His Gly Glu Pro Gln Gln Glu Leu Leu Gln Cys Tyr Leu 3755 3760 3765 Lys Asp Phe Ile Leu Leu Thr Met Arg Val Ser Thr Glu Glu Glu 3770 3775 3780 Leu Lys Phe Leu Gln Met Ala Leu Trp Ser Cys Thr Arg Lys Leu 3785 3790 3795 Lys Ala Ala Ser Glu Ala Pro Glu Glu Glu Val Ser Leu Pro Trp 3800 3805 3810 Val His Leu Ala Tyr Gln Arg Phe Arg Ser Arg Leu Gln Asn Phe 3815 3820 3825 Ser Arg Ile Leu Thr Ile Tyr Pro Gln Val Leu His Ser Leu Met 3830 3835 3840 Glu Ala Arg Trp Asn His Glu Leu Ala Gly Cys Glu Met Thr Leu 3845 3850 3855 Asp Ala Phe Ala Ala Met Ala Cys Thr Glu Met Leu Thr Arg Asn 3860 3865 3870 Thr Leu Lys Pro Ser Pro Gln Ala Trp Leu Gln Leu Val Lys Asn 3875 3880 3885 Leu Ser Met Pro Leu Glu Leu Ile Cys Ser Asp Glu His Met Gln 3890 3895 3900 Gly Ser Gly Ser Leu Ala Gln Ala Val Ile Arg Glu Val Arg Ala 3905 3910 3915 Gln Trp Ser Arg Ile Phe Ser Thr Ala Leu Phe Val Glu His Val 3920 3925 3930 Leu Leu Gly Thr Glu Ser Arg Val Pro Glu Leu Gln Gly Leu Val 3935 3940 3945 Thr Glu His Val Phe Leu Leu Asp Lys Cys Leu Arg Glu Asn Ser 3950 3955 3960 Asp Val Lys Thr His Gly Pro Phe Glu Ala Val Met Arg Thr Leu 3965 3970 3975 Cys Glu Cys Lys Glu Thr Ala Ser Lys Thr Leu Ser Arg Phe Gly 3980 3985 3990 Ile Gln Pro Cys Ser Ile Cys Leu Gly Asp Ala Lys Asp Pro Val 3995 4000 4005 Cys Leu Pro Cys Asp His Val His Cys Leu Arg Cys Leu Arg Ala 4010 4015 4020 Trp Phe Ala Ser Glu Gln Met Ile Cys Pro Tyr Cys Leu Thr Ala 4025 4030 4035 Leu Pro Asp Glu Phe Ser Pro Ala Val Ser Gln Ala His Arg Glu 4040 4045 4050 Ala Ile Glu Lys His Ala Arg Phe Arg Gln Met Cys Asn Ser Phe 4055 4060 4065 Phe Val Asp Leu Val Ser Thr Ile Cys Phe Lys Asp Asn Ala Pro 4070 4075 4080 Pro Glu Lys Glu Val Ile Glu Ser Leu Leu Ser Leu Leu Phe Val 4085 4090 4095 Gln Lys Gly Arg Leu Arg Asp Ala Ala Gln Arg His Cys Glu His 4100 4105 4110 Thr Lys Ser Leu Ser Pro Phe Asn Asp Val Val Asp Lys Thr Pro 4115 4120 4125 Val Ile Arg Ser Val Ile Leu Lys Leu Leu Leu Lys Tyr Ser Phe 4130 4135 4140 His Asp Val Lys Asp Tyr Ile Gln Glu Tyr Leu Thr Leu Leu Lys 4145 4150 4155 Lys Lys Ala Phe Ile Thr Glu Asp Lys Thr Glu Leu Tyr Met Leu 4160 4165 4170 Phe Ile Asn Cys Leu Glu Asp Ser Ile Leu Glu Lys Thr Ser Ala 4175 4180 4185 Tyr Ser Arg Asn Asp Glu Leu Asn His Leu Glu Glu Glu Gly Arg 4190 4195 4200 Phe Leu Lys Ala Tyr Ser Pro Ala Ser Arg Gly Arg Glu Pro Ala 4205 4210 4215 Asn Glu Ala Ser Val Glu Tyr Leu Gln Glu Val Ala Arg Ile Arg 4220 4225 4230 Leu Cys Leu Asp Arg Ala Ala Asp Phe Leu Ser Glu Pro Glu Gly 4235 4240 4245 Gly Pro Glu Met Ala Lys Glu Lys Gln Cys Tyr Leu Gln Gln Val 4250 4255 4260 Lys Gln Phe Cys Ile Arg Val Glu Asn Asp Trp His Arg Val Tyr 4265 4270 4275 Leu Val Arg Lys Leu Ser Ser Gln Arg Gly Met Glu Phe Val Gln 4280 4285 4290 Gly Leu Ser Lys Pro Gly Arg Pro His Gln Trp Val Phe Pro Lys 4295 4300 4305 Asp Val Val Lys Gln Gln Gly Leu Arg Gln Asp His Pro Gly Gln 4310 4315 4320 Met Asp Arg Tyr Leu Val Tyr Gly Asp Glu Tyr Lys Ala Leu Arg 4325 4330 4335 Asp Ala Val Ala Lys Ala Val Leu Glu Cys Lys Pro Leu Gly Ile 4340 4345 4350 Lys Thr Ala Leu Lys Ala Cys Lys Thr Pro Gln Ser Gln Gln Ser 4355 4360 4365 Ala Tyr Phe Leu Leu Thr Leu Phe Arg Glu Val Ala Ile Leu Tyr 4370 4375 4380 Arg Ser His Asn Ala Ser Leu His Pro Thr Pro Glu Gln Cys Glu 4385 4390 4395 Ala Val Ser Lys Phe Ile Gly Glu Cys Lys Ile Leu Ser Pro Pro 4400 4405 4410 Asp Ile Ser Arg Phe Ala Thr Ser Leu Val Asp Asn Ser Val Pro 4415 4420 4425 Leu Leu Arg Ala Gly Pro Ser Asp Ser Asn Leu Asp Gly Thr Val 4430 4435 4440 Thr Glu Met Ala Ile His Ala Ala Ala Val Leu Leu Cys Gly Gln 4445 4450 4455 Asn Glu Leu Leu Glu Pro Leu Lys Asn Leu Ala Phe Ser Pro Ala 4460 4465 4470 Thr Met Ala His Ala Phe Leu Pro Thr Met Pro Glu Asp Leu Leu 4475 4480 4485 Ala Gln Ala Arg Arg Trp Lys Gly Leu Glu Arg Val His Trp Tyr 4490 4495 4500 Thr Cys Pro Asn Gly His Pro Cys Ser Val Gly Glu Cys Gly Arg 4505 4510 4515 Pro Met Glu Gln Ser Ile Cys Ile Asp Cys His Ala Pro Ile Gly 4520 4525 4530 Gly Ile Asp His Lys Pro Arg Asp Gly Phe His Leu Val Lys Asp 4535 4540 4545 Lys Ala Asp Arg Thr Gln Thr Gly His Val Leu Gly Asn Pro Gln 4550 4555 4560 Arg Arg Asp Val Val Thr Cys Asp Arg Gly Leu Pro Pro Val Val 4565 4570 4575 Phe Leu Leu Ile Arg Leu Leu Thr His Leu Ala Leu Leu Leu Gly 4580 4585 4590 Ala Ser Gln Ser Ser Gln Ala Leu Ile Asn Ile Ile Lys Pro Pro 4595 4600 4605 Val Arg Asp Pro Lys Gly Phe Leu Gln Gln His Ile Leu Lys Asp 4610 4615 4620 Leu Glu Gln Leu Ala Lys Met Leu Gly His Ser Ala Asp Glu Thr 4625 4630 4635 Ile Gly Val Val His Leu Val Leu Arg Arg Leu Leu Gln Glu Gln 4640 4645 4650 His Gln Leu Ser Ser Arg Arg Leu Leu Asn Phe Asp Thr Glu Leu 4655 4660 4665 Ser Thr Lys Glu Met Arg Asn Asn Trp Glu Lys Glu Ile Ala Ala 4670 4675 4680 Val Ile Ser Pro Glu Leu Glu His Leu Asp Lys Thr Leu Pro Thr 4685 4690 4695 Met Asn Asn Leu Ile Ser Gln Asp Lys Arg Ile Ser Ser Asn Pro 4700 4705 4710 Val Ala Lys Ile Ile Tyr Gly Asp Pro Val Thr Phe Leu Pro His 4715 4720 4725 Leu Pro Arg Lys Ser Val Val His Cys Ser Lys Ile Trp Ser Cys 4730 4735 4740 Arg Lys Arg Ile Thr Val Glu Tyr Leu Gln His Ile Val Glu Gln 4745 4750 4755 Lys Asn Gly Lys Glu Arg Val Pro Ile Leu Trp His Phe Leu Gln 4760 4765 4770 Lys Glu Ala Glu Leu Arg Leu Val Lys Phe Leu Pro Glu Ile Leu 4775 4780 4785 Ala Leu Gln Arg Asp Leu Val Lys Gln Phe Gln Asn Val Gln Gln 4790 4795 4800 Val Glu Tyr Ser Ser Ile Arg Gly Phe Leu Ser Lys His Ser Ser 4805 4810 4815 Asp Gly Leu Arg Gln Leu Leu His Asn Arg Ile Thr Val Phe Leu 4820 4825 4830 Ser Thr Trp Asn Lys Leu Arg Arg Ser Leu Glu Thr Asn Gly Glu 4835 4840 4845 Ile Asn Leu Pro Lys Asp Tyr Cys Ser Thr Asp Leu Asp Leu Asp 4850 4855 4860 Thr Glu Phe Glu Ile Leu Leu Pro Arg Arg Arg Gly Leu Gly Leu 4865 4870 4875 Cys Ala Thr Ala Leu Val Ser Tyr Leu Ile Arg Leu His Asn Glu 4880 4885 4890 Ile Val Tyr Ala Val Glu Lys Leu Ser Lys Glu Asn Asn Ser Tyr 4895 4900 4905 Ser Val Asp Ala Ala Glu Val Thr Glu Leu His Val Ile Ser Tyr 4910 4915 4920 Glu Val Glu Arg Asp Leu Thr Pro Leu Ile Leu Ser Asn Cys Gln 4925 4930 4935 Tyr Gln Val Glu Glu Gly Arg Glu Thr Val Gln Glu Phe Asp Leu 4940 4945 4950 Glu Lys Ile Gln Arg Gln Ile Val Ser Arg Phe Leu Gln Gly Lys 4955 4960 4965 Pro Arg Leu Ser Leu Lys Gly Ile Pro Thr Leu Val Tyr Arg His 4970 4975 4980 Asp Trp Asn Tyr Glu His Leu Phe Met Asp Ile Lys Asn Lys Met 4985 4990 4995 Ala Gln Asp Ser Leu Pro Ser Ser Val Ile Ser Ala Ile Ser Gly 5000 5005 5010 Gln Leu Gln Ser Tyr Ser Asp Ala Cys Glu Val Leu Ser Val Val 5015 5020 5025 Glu Val Thr Leu Gly Phe Leu Ser Thr Ala Gly Gly Asp Pro Asn 5030 5035 5040 Met Gln Leu Asn Val Tyr Thr Gln Asp Ile Leu Gln Met Gly Asp 5045 5050 5055 Gln Thr Ile His Val Leu Lys Ala Leu Asn Arg Cys Gln Leu Lys 5060 5065 5070 His Thr Ile Ala Leu Trp Gln Phe Leu Ser Ala His Lys Ser Glu 5075 5080 5085 Gln Leu Leu Arg Leu His Lys Glu Pro Phe Gly Glu Ile Ser Ser 5090 5095 5100 Arg Tyr Lys Ala Asp Leu Ser Pro Glu Asn Ala Lys Leu Leu Ser 5105 5110 5115 Thr Phe Leu Asn Gln Thr Gly Leu Asp Ala Phe Leu Leu Glu Leu 5120 5125 5130 His Glu Met Ile Ile Leu Lys Leu Lys Asn Pro Gln Thr Gln Thr 5135 5140 5145 Glu Glu Arg Phe Arg Pro Gln Trp Ser Leu Arg Asp Thr Leu Val 5150 5155 5160 Ser Tyr Met Gln Thr Lys Glu Ser Glu Ile Leu Pro Glu Met Ala 5165 5170 5175 Ser Gln Phe Pro Glu Glu Ile Leu Leu Ala Ser Cys Val Ser Val 5180 5185 5190 Trp Lys Thr Ala Ala Val Leu Lys Trp Asn Arg Glu Met Arg 5195 5200 5205 <210> 2 <211> 235000 <212> DNA <213> Homo sapiens <400> 2 acccaggagg tggaggttgc agtgagccaa gatcgcgcca ctgtactcca gcctgggtta 60 cagagtgaga ctctgtctca aaaaaaagaa aaaaaagaaa aagaaaagaa aaagaccaca 120 cattaatcca ggactgtggg gctcctccca ggaggaggtg gccctgaccc ctgacctgta 180 tgcttcctgg gaaatgtgct tctggggagg acagagggag gaggaaggag agggaggaag 240 aggaaggcag gggagagaag ggaggcatta caggaggctt tgagcccagg ggaagagggg 300 ttttccctct ggtctggtgg gtccggcacg gaggcggggg gagagcatga tgggagcaca 360 gtgggaaggg gacccaggtt tacctccggg tcaggagcct ggctgtggtc tggcatggag 420 gcagggggag ggcatgatgg gagcacagtg ggaaggggac ccaggtttac ctccgggtca 480 ggagcctggc tgtggtctgg catggaggca gggggagggc atgatgggag cacagtggga 540 aggggaccca ggtttacctc cgggtcagga gcctggctgt ctcctgtgtc taaggaacag 600 gcccgggagt ctgcagggcc cctctctggg gcgtgctttt ccccctcagt ctcctgggca 660 cagcctgggg acctgctcat tggcaggaca gaggctgcct gggctttcgg gggagcacac 720 agatgccgtt ccctccctcc ctcttttctc ccgtatctcc cacgttcagg gtgaacccag 780 aaaaccctgg ggaatggaag tgctttggga atgtgggctt ctgccaaggc ctgtggtccc 840 tccatcgtag ccactccttg agcagcctgt gccagcaggg aggagaggag ggggtgcagc 900 atctcgccgg gaacctgagt ccacagccga ggatgactga ccctccctct tgtgtgacaa 960 caggattctg caggacagag agatgaaact ggaaataatt cagtccaaac agtcttccaa 1020 gggacccttg ctgctacgaa aaggtggctc cgagaagttt ttacaaagaa catgctcaca 1080 tcttcaggtg cctcattcac atacgtcaag gaaattgagg taggcatttg gccgaaggct 1140 tctgggtagg gatgtgactg atcgtgattc ctcatggcct caaatcatgg ggtacaggct 1200 gctggccagg ggcagttgtt ggccttcacc tgagcctcag ttcttcatct acaaaatgga 1260 gttgctcctg tctacctggc agggtggctc tgaggcagac agatgccggg tgcaaagtgc 1320 tgctgcactg cctcgtgtcc cctggccggg cacagtccct gtggtgatgg aggtgtggag 1380 gtgatggtga tggttggtgg tggtggtggt agaggtgatg gtggtggagg tgatggtgat 1440 ggttggtggt ggtggtggta gaggtgatgg tggtgaaggt gatggtgatg gtggacgtaa 1500 tggaggtgat ggtggtgatg gtggtcatgg aggtggtgga ggtgatggtg gtggtggagg 1560 tgatggtgat tgtggtggag gtgatggtgg tgatggtgat ggttgtggag gtgatggtgg 1620 aggtaatgga ggtgatggtg gtggtgaagg ggatggtggt gatggaggtg gtggtggtgg 1680 aggtgacaat ggtgatgctg gtggtggagg tggtggaggt actggaggtg atggtggtgg 1740 tgaaggtgat ggtggaggta atggaggtga tggtggtggt ggaggtgatg gtggaggtac 1800 tggaggtgat ggtggtggtg aaggtgatgg tggaggtact ggaggtgatg gtggtggtgg 1860 tggtgatggt ggaggtggtg gaggtaatgg aggtgatggt ggtggtggag gtgatggtgg 1920 aggtactgga ggtgatggtg gtggtgaagg tgatggtgga ggtaatggag gtgatggtgg 1980 tggtggtggt gatggtggag gtggtggagg taatggaggt gatggtggtg gtggaggtga 2040 tggtggaggt actggaggtg atggtggtgg tgaaggtgat ggtggaggta ctggaggtga 2100 tggtggtggt gtaggtgatg gtggaggtga tggtggtggt gaaggtgatg gtggaggtaa 2160 tggaggtgat ggtggtggtg aaggtgatgg tggaggtact ggaggtgatg gtggtaaagg 2220 tgatggtgga ggtactggag gtgatggtgg tggacgtgat ggtggaggta atggaggtga 2280 tggtggtggt ggtggtggtg gaggtactgg aggtgatggc ggtcgtggag gtgatggtgg 2340 aggtaatgga ggtggtggtg gtggtggtgg tggaggtact ggaggtgatg gtggaggtaa 2400 tggaggtgat ggtggtgatg gtgatggtgg aggtactgga ggtgatggtg gtggtggtgg 2460 aggtaatgga ggtgatggtg gtggtgaagg tgatggtgga ggtaatggag gtgatggtgg 2520 tggtggtggt ggtggtggag gtaatggagg tgatggtggt ggtggtggtg gtggtggagg 2580 tactggaggt gatggcggtc gtggaggtga tggtggaggt aatggaggtg gtggtggtgg 2640 tggtggtgga ggtactggag gtgatggtgg aggtaatgga ggtgatggtg gtgatggtga 2700 tggtggaggt actggaggtg atggtggtgg tggtggaggt aatggaggtg atggtggtgg 2760 tgaaggtgat ggtggaggta atggaggtga tggtggtggt ggtggtggtg gtggaggtaa 2820 tggaggtgat ggtggtggtg gaggtgatgg tggaggtact ggaggtgatg gtggtggtga 2880 aggtgttggt ggaggtactg gaggtgatgg tggtcgtgta ggtgatggtg gaggtgatgg 2940 tggtggtgaa ggtgatggtg gaggtactgg aggtgatggt ggtggtgaag gtgatggtgg 3000 aggtaatgga ggtgatggtg gtggtgaagg tgatggtgga ggtaatggag gtgatggtgg 3060 taaaggtgat ggtggaggta ctggaggtga tggtggtaaa ggtgatggtg gaggtaatgg 3120 aggtgatggt ggtggacgtg atggtggagg taatggaggt gatggtggtg gtggtggtgg 3180 aggtactgga ggtgatggtg gtggacgtga tggtggaggt aatggaggtg atggtggtgg 3240 tggtggtgga ggtaatggag gtgatggtgg tggtggtgat ggtggaggta ctagaggtga 3300 tggcggtcgt ggaggtgatg gtggaggtaa tggaggtgat ggtggtggtg gtggtggtac 3360 tggaggtgat ggtggaggta atggaggtga tggtggtggt ggtggtggta ctggaggtga 3420 tggtggaggt aatggaggtg gtggtggtgg tggtggtgga ggtactggag gtgatggtgg 3480 aggtactgga ggtgatggtg gtcgtggagg tgatggtgga ggtaatggag gtgatggtgg 3540 tggtggtggt ggtactggag gtgatggtgg tccgtggagg tgatggtggt ggtggtaatg 3600 gaggtgatgg tggtggtact ggaggtgatg gtggtggtga aggtgatggt agaggtaatg 3660 gaagtgatgg tggaggtact ggaggtgatg gtggtggtgg tggaggtgac agtggtgatg 3720 ctggtggtgg tggtggtggt ggtggtggtg gtggaggtgg tggtggtggt ggtggtggtg 3780 atggtgatgg tggtggtggt ggtggtggag gtgatggtgg aggtaatgga ggtgatggtg 3840 gtggtgaagg tgatggtggt gatggaggtg gtggtggtgg aggtgacagt ggtgatgctg 3900 gtggtggagg tggtggaggt actggaggtc atggtggtgg tggaggtgat agtggtgaag 3960 gtgatggagg tggtggaggt tatggagata atggtggtgg tggaggtgat agatatttga 4020 acatgcctga cctaagaaaa gttcattttc atttttggct gggcactatg gctgatgcct 4080 gtaaccccaa ctctttagga agcctaggtg gaagggtggc ttgaacccag gaggtcaggg 4140 ctgcagtgag ctatgactgt gccactgcac tccaacccag gtgacggagc gagaccctgt 4200 ctcttaaaat atttttttta cagtgcattt tcatgtgttt caacctccta gtgtccctgc 4260 caaaaatatt ttaatctgaa tcaaatcatg gggaaattat gagacaaatc aggtcaaaag 4320 acagtttaca aaacagttgg cctgaacttt tcaaaactgt caacatgtta aaagaaaaaa 4380 gaaaaaaatg accagggaac tcttctagaa aagagatgtg ataagtaaat gcagaaaaga 4440 gacgtgataa gtaagtacag cgtgtgtccc aggaggatct aggatccagt caggacagga 4500 gctggagcac gagaggaacg ggggtggaga ccacttcctg ggggcagagt gtcctcctct 4560 ccacgttgca cgtcctgagt gggaaacctg cactggagtt gcacagggaa gggctagggt 4620 cttaggagac cctgcccagg tatgtagtgg caaggtgcca tgatgcctgc aacttacttt 4680 ccaacggttt gggagagaaa atgctcattt gtgcagagtc cgaagaggga gcacagagga 4740 gagaggaaga gtgaaagcag ctgtgygaag cgtgaatcgc acaggactgg agttgaatga 4800 atgtgggtgg tggtgtgcta ttcttgcgac ctttttgaaa gttcaaaaat tttcaaagta 4860 taacatgaga gataagtcct ttcagaataa aaagccggtt gtgcagtagg aggaccagta 4920 gtggcccctg gttgggtctc tgattctaga aagccaacct gggctgctgt gaccggccac 4980 tagcatggct gactgttgat gaaggttggg gagagccctg gtgttcgcgg agtcccgcgc 5040 tctctgtatt gccgtaatgc tctgtctttc tcctttcatg ggagtgtgcc gtggcattta 5100 gtcgtgagag tgggtgtgac ctgtgtgcgg gttttgcagg tctggaggcg gctggtggaa 5160 atccaattcc ccgcggagca tggctggaag gagtcgttgc tgggagacat ggaatggagg 5220 ctcacaaagg taccaaaagt ttgggggcag tcttttcagg gcgtgaaggc aagctggaga 5280 accccagacc attagcgaca gccaagagat ctcagcagtg cctctctgtg ggcagggatg 5340 gggtgaatca cagctccgtg tttctgtttc tgatccagcc cttatagtct gtccctagaa 5400 gagcgcttcg gagtcttact gagaggacag agaagaacaa gggcccagga tctcaccatc 5460 atgggggtgc gggatttttc ctgacccctt cgttggactt gcgacaggga tgctgtgttt 5520 acttggcccg ccgtgctcaa ccccttgtgg gagggagcac gtgagtgagt gtggcatctg 5580 gccagctgct ttgggagctg gcaggagcaa gctccgtgca ggccctgcag cagtgcccag 5640 attgaggtgc ctgcaacccc cgaagctcca gagggcatgt tacagtgctc tcttagctcc 5700 gccgtctatg gacagtagtg tgttatcagc tcagtgggtc ccttgccttg ttgcctaggg 5760 tggctgccct ctgccagggc caatgtgaca gcctctttta ggtacccaca ctcggtgggt 5820 cccaagctct tgtccagcat ccaagaagaa tggggtcacc cggacacttg aaggatggtg 5880 aaggtggaga attttattaa gcaatggaaa tggctctcca tggagagggg agctggagag 5940 gggatgggtc aggtggggaa tcttcctctg gtccaggtgt ctggctggct cttccctgaa 6000 gtcaggacgt ctttccgaag ttaaaccgtc tctccttgga agtccagcca tccctctgaa 6060 gtcaagtcac ctgtttccag tgaagctact tctctctcac taccaagtct ggggtcttta 6120 taggcacaag atagggggca gggtgggccc taggtagttt tggaaaaagc aacattctat 6180 tggtaaaaag acattactcc gaaagaacca gtggggagag agtaggcaca cggggataga 6240 ggttctcact ttgggccatg ggtttcaggc ttttcggctc gaaggtgggg ttttgccagg 6300 gacccgcccc tgtctgcgta ggatttctct gcctcctgcc tccatcaatg gggccccagg 6360 cacaggaggg gccaggcctg cccataggca ggaagtctaa gtggcctgtt ggtgacagga 6420 acctcatgac acacaagtgg agaacacaca gacatgcccc tcatgctgaa ttaaggcctg 6480 aggctcaagg aaaattagtt tttatgtgat atgagagttt tatatgtaac tttttttttt 6540 tttgagacgg ggtctcgctc tatcgcccag gctggagtgc agtggcggga tctcggctca 6600 ctgcaaactc cgcctcccgg gttcacgcca ttctcctgcc tcagcctccc gagtagctgg 6660 gactacaggc gcccgccacc gcgcccagct atatttttgt attttttgta gagacggggt 6720 ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc gtgatccacc cgcctcagcc 6780 tcccaaagtg ctgggatgac aggcgtgagc caccgcgccc ggcctatatg taactgttaa 6840 atggatcttt aaagggaaaa gtcagaaaca aggaaaaatg acctatgtct cataacttac 6900 ctgtttttgc aagccaggtg ctttttctgc agagtgggaa aagagactct tttaaatttt 6960 agcctttggt ctactggtgg ggggcaggga ggacatgctt tgcgtgggcc aggagaagct 7020 taaaattggg ggaaacagta aaacagcagg aaagtaaaaa tgatgaaaga attttcatcc 7080 catagagcac tggagcgctg catccgaaag ctctgaaacc accccccttt gatttttgca 7140 ggaggaaccc ctctcccaga tcactgccta ctgcaatagt tgctgggaca ccaaaggctt 7200 agaggacagt gtggccaaga ccttcgagaa atgcatcatt gaagccgtga gctcagcctg 7260 ccaggtgaac aatctctcct cctgggaaac ggattcgggc tcacagctgt gttctgccat 7320 gacccagcta agggctatga agcacccgct gggtctcagc tcctccgcta actcagagat 7380 tgggaagtgg gcaccctcct ccctcgccaa gggcaatggc gctgaaatct agttctctcc 7440 ggattcctca gtgtgctgca cagtccctgc tgctcgcacc atcctgcatg tgttccatat 7500 ggaatcacgg ccgtgcgcgt gtggcacaag tcacacgggc ttgcaggccg ttcctcagat 7560 ggccctgtca tcactgtggc tgctggtttg attgattgtt aacacttgct cagtaggtgt 7620 gcgggaagag actccaaagg ttgacagaac atttatggaa gcaaaatatg tgaaatggaa 7680 aattgtatca atttatttag ctcttttcgg caaaggggaa gagattgtgc ccccctgtct 7740 cccaggaaca gtctcgcagg caatgccaca tgaggaagct ccctgctggc cacggctgcc 7800 ctgctcacat ttcctaattg gacacttaac ccctgtacaa gcacagcctt gcggccacag 7860 gggaagtcca gaaacattga ggtcattgaa ttccggggac caaggggttc taatttttta 7920 agtgactgat acctttgata aggttttcct ttcccttttt cgttaactct ttgttgagat 7980 attgttcgta tgccatacgg tacatctgtc aaaagttcca gttcagcagg ttttggggta 8040 gtcacagata tgtacagtca tcaccacagt taatgacaga gcattttcat cacttcaaag 8100 agaaacccgg cccctttagc catcatcctc ctcccctcta gtcacccact cccctctgca 8160 ggcataaaca attgctgaac ataaacaact gcttctgtgg ctttctctgt tctgactgtc 8220 atatgaatgg aatcatatca tatgtggcct tttgggtatg gcttatttca ctgagcataa 8280 tgtttttttg ttgttggtgg tggtggttgt ttgttgtttt tgagacagag tttcactctt 8340 tttgcccagg ctggagtgca atggtgcgat cctggctcac cgcaaccgct gcctcccggg 8400 ttcaagtgat tctcctgcct cagcctccca agtgctggaa ttacagctac tttttgttta 8460 aagagtcttt taattgttta aagaacaatg tgccgccaca ctcggttcct tttgtatttt 8520 tagaagagac agggtttctc catgttggtc aggctggtct cgaactcccg acctcaggtg 8580 atccacccac cttggcctcc cgaagtgccg agattacagg tgtgagccac cgcgcccggc 8640 cgagcataat gttttgaaag accgctcagg ctggacacgg ttgctcacgc ctgtaatcac 8700 ggcactttgg gagcccagga gttcaagaca agcctgggta acagagtaag accctgtctc 8760 tataaaaact aaaaaataaa caaaaaaaat tagccaggca tggccgggca cacctgtggt 8820 cccagctact tgggaggctg aggtgggagg ctcccttggg cccagaaggt caaggcagca 8880 gtgagccatg atcacaccac tgcacttcaa cctgggggac agagcaagac cctgtctcaa 8940 aaagcaataa caacaaaagt ccatccatat tgtagcttgt gtccgtttac gttaagtatt 9000 ccttacccaa aatgcttgag accagaagtg ttttggattt cagatgtttt caaattttgg 9060 aatatttgca tttacataat gagatgtctt ccagatggga cccagagtct aaccacaaaa 9120 ttcacttgtt tcatatacat cttatacaca tagcctgaag gtaattttat acaatatttt 9180 taacaatttt gtgcatgaga caaagtttgt attaagtatt tgtatgttga atttttcact 9240 tgtggcatca ttatactcaa aaagtttgga ttttgtagta ttttggattt ggggattagg 9300 aatgctcaac ctatatttca tttttttcca tggccaaata ttccccgttt atccatgtgt 9360 ccattgacgg ccatctatgt tgcttcttcg gctattataa atctgctgat acaaacatta 9420 gtgtacatat ttatgtgtgg gtgtatgtct tcatttctcc tgggtgtata cctcgatgta 9480 gaattgctga atcatatggt aactccatgt ttaattgttt aaagaactgt ccggccgagt 9540 cccacagcag ctgaaccatt ttcaatccct ccagcagcat aggaggcttc caggttctcc 9600 acatcctcac taacatgtgt tgtctaactt tttgattcta gccatcctgg tgggtatgaa 9660 gtggtatctc cttgtggttt ttgtttgttt tttgagatgg agtcttgccc tgtcacccag 9720 gctggagtgc agtggcgtga tcttggctca ctgcgacacc tccacctcct gggttcaagc 9780 aattctcctg cctcagtctc tcgagtagct gggactacag gcatgtgcca ccatgcccag 9840 ctaatttttg tatttttggt agagacgggg ttttgccgtg tgggtcatga tggtctcgat 9900 ctcttgacct catgatccac atgccttggc ctcccaaagt gctgggatta caggcgtgag 9960 ccactgtgcc cggcctcatt gtggttttta actgcatttc tctgataact aatgatatca 10020 agcatctttt catatgctta ttggatttgt ctgtatcttc tttggagaaa tgtttattga 10080 gatattttgc ccctcatccc ccccaccccc cctttttttt tttttttttt gagaaaaggt 10140 ctcgctttgt cacccaggct ggaatacaat ggcacgatca cagctcacta cagcctcaac 10200 ctcctgggct gaagtggtcc tcccacttta gcctcccgag tagcagggac tacaggcatg 10260 tgccaccatg ttcagctaat taaaaaaaaa atttctgtgg gccgggcatg gtggctcatg 10320 cctgtagacc atcctggcta acacggtgac accctgtctc tactaaaaat acaaacaatt 10380 agctgggcat ggtggcatgt gcctgtagtc ccagctgctt gggaggctga ggccagagaa 10440 tcacttgaag ccatgaggtg gaggttgcag tgagctgaga ttgtgccact gcactccggc 10500 ctgggcgaca gagcgagact ctgtctcaaa aaaaaaaatt ttttttcgta gagacagggt 10560 cttgagatgt tgcccaggct ggtcttgaac tcctggactc acatgaacct ccctccttgg 10620 ccttccaaag tgttgggatt gaaggcatga gccaccgcac ctggcctctt ttgctcattt 10680 ttaaattggg ttgtcttttt attatagagt tgggagtctt tattctatat acaagtcact 10740 tgtcagatat atgattgcaa gtattttctc ccattctatg tgttgttttt tcacattctt 10800 attggtttct tttgaagcac agaagtcttt aattttgaag aagttagcat atctgttttt 10860 tcttttgttg cttgtacttt tggtgtcaaa gaatcctttg ccaaatccta ggtgatgaag 10920 atttactcct atgtttattt atctctaaat gttttatagt tttagctctt acatgtaggc 10980 ctttgatcca ttttgagttc ctttttatat atggtgtata tggtgtgagg taagggttct 11040 gtttcattct cttgcatgtg gacatccagt tgtcccagca tttgttgaaa ggactctaca 11100 ttccctgttg agtgatgttg gcactcttgt caaaaatctg ttgacgatac atgtatggat 11160 ttatttctag attttcaatt ctatgtggtg atctacttgc ctatccttgt gtcagtacca 11220 cactgtttgg actaccattg ctttctagta agttttgaaa ttgggatgtg tgagtcctcc 11280 tactttgttc ttatttttca agattgtttt ggctattttg ggtcccttgc aatttcataa 11340 gaattttaga atcagtatgt cagtttccac tgacaaggaa gtcagctggg attctggtag 11400 ggctggtatt caatgtatag atcagtttgg agagcattgc catcttaaca aggttaagtt 11460 ggatttcttt cattcaatta gatttttttt tttcccctgt tagacagagt ctcgccctgt 11520 tgcccaagct ggagtgccca agtagctggg actacaggtg tccaccacca tgcctggcta 11580 atttttgtat ttttagtagt ttcaccatat tggtcagggt ggtctcgaac tcctgacctc 11640 agatgatcaa cccgccttga cctcccagag tcctgggatt acaggcatga gccaccattc 11700 ctggccaatt tcttttaaca atgttttgta tttttcatag tttaaatttt gcacttcttt 11760 tgttaaattt ctaagtactt ttttttgggg gggggtgcta ttgtaattgg aattgttttc 11820 tgaattctgt ttccagattg ttccttgctg gtgtctagac acacagtgct ccatgcgtct 11880 tgtatcctgc aacattgctg agctcatttg gtagctcaaa ttgtgtgtgc gtgtgtgtgt 11940 gtgtgtgcat gagagagaga attaaatttt ctatacataa gatcatatca tctgtgaata 12000 gagtttcact tcttccaatc tggatgcctt ttatttcttt ctcttgcata actgccctgg 12060 ctagaacctc cagtacaatg ttgaatgaaa gtattgaaag tggacatctt tgtcttgttc 12120 tgatcttaag agaaggtttc agtcttttgc caccaggtgt gatgtcaacg tgagcttttc 12180 atagatgccc tttatcagtt tgtggaagtt cctttttgtt cctcatttgt tgaatgcttt 12240 tttttcttta atcatagaag agagttggat tttgtcaaat gcttttcccg tatctactga 12300 aatgatcatg cgatattttc ctaatgttat taactgatat ttgatgttaa atcaaccttt 12360 catccctgag ataaattaca cttgatcgtg gtgtatagtt cctttaacat ggggctggat 12420 aaggttttct tttatccttt taaatgtcag aaagtatcta ttataaatta accttgtggt 12480 ttttactaat tactgaaatg ttttacagaa actttgaacc taaaggaaga aaaatattgt 12540 ttctcggagg agaattaaaa agagaattaa aatgtatatg ttgtttgtag gcagcttttt 12600 aaaagaatta tggtttagga acataaaata tatgctatat taagggttta ttcatttttg 12660 gtatttttca tgatatgaaa gtccaaaaaa aaatgtagaa actggcagcc agaaggaagg 12720 agggtgactg gttatgttgg tgtgtgtttg tgtgtgtgtc ttcacatctc tggtgctgga 12780 cacttaagga ggcagtatac aaggaaatga aaattttcga agaaatgtaa agtgttttac 12840 tattttgctc tttttgtggc cttataaaac aagttacagt agatttcaga aatgctatcg 12900 agtaggtaat ttgcttttgt tatttcaaaa caaactaatg aaaaacttct aaatgtccct 12960 cttttattaa ttttcttgta gtctcagacc agtatccttc aggggttctc ttactctgat 13020 ttgcggaaat ttggcatcgt cttgtctgct gtgatcacta agtcctggcc taggaccgcg 13080 gacaacttca atgacatttt aaagcatctg ctcacgttgg cagatgtcaa gcacgtcttc 13140 agattgtgtg gtatgtttgc gggagtgctg ggaacatcag ctcaggcaag gtggtgtctt 13200 cctgattggg aaaggtggga ggcagaagat ttgacatgat gatactgaat tgggatgggc 13260 tgatgtttga caaaggctgc agtttggaca gagagaccct ggaaggctca gagtgtcttg 13320 cgttgtaaat aataactaat gctaacagcc actattcatt gaatgcttgc tgtaccctag 13380 cgactgtgct gggtcgcaag ggaagtgccc ttgaaacaac ccttctgaaa gtccccttta 13440 aggcccccag ttttcagatc aggaaacaaa tggagaaggc aatgcgactt acctaaggtc 13500 tcaaagatta taagtagtaa aaactaaaat ccagacccag gtatgtctta tttggagatc 13560 aatatagaat gtccaagcca acattgatga cctcaacaga aagtgaagta ctgtgctgtc 13620 tgatttcccc ccagcccccc gcgccccagg tgttttgtgg tcaaggaggg agagagagag 13680 acattccatc ctaaaaacgt tagagtccag ttggcgtgtg agaccttaga ttcatatctt 13740 tcagtgagaa ggcgctggat gtggaacagc caaaatcaat gctgagcttc ctacacatca 13800 gggaagctgt ggggatcaaa taactgaatt aatatgggag tgcacaagta aaagctactc 13860 tcttgaaaag atcatttttg tgttatttgt atttatttat ttatttattt atttatttat 13920 ttattttgga gatggagtct cgctctctca cccaggctgg agtgcagtgc tgtgatctca 13980 gctcactgca acctctgcct cccgggttca agcgattctc ctgcctcagc ctcccaagta 14040 gctgggatta cagatgtgag ccactgtgcc cagcagttta tttaatttta aaacaaggtc 14100 ttctctgttg cgcaagttag catgtagtag agtgatgcca tcatcgctca ccgtaagcgc 14160 tgacctcccg ggctcacgtg atcctcctgc ctcagcctcc caagtggctg gcactccagg 14220 cgtgcaccac catacccagc ctgtttataa gttggataga attttttaga gcactttgat 14280 gtgtacagaa aaattgagca gaaagtacag agagttgtca tctatctctg ccaccatcac 14340 acgggcagta ccctgttagt aacatgcagc attagtgtgg tgcttttgtt acagctgaga 14400 agccaatatt gataacactg ttattaacta aagtccatag ttcgttcctg gtgttgtcca 14460 ttctctgagg tttggataaa ccatggcctg tgtccaccat tccagtatcg tgcagaatag 14520 ttgcgctgcc cctacaaaat cccatgctcc acccctccca tttcctttag tcttttccag 14580 aatgtcctat ggttggaatc ttataggatg tcgcctttag actggcttcc ttcacttagt 14640 aatacgtatt tatgtttcct ccatgtcttt tcatggcttg agagctaact tcgttttacc 14700 actgaataat attctattgt atggatgtgc taccattcgc ttacccgttc acctcatgaa 14760 agacatcttg gttgcttcca agtttttgca atgattagta aagctactat gtttgtttct 14820 tatggtgcag ataagcttca tcttctccta atattgtatg gctctaatat tactgggaga 14880 gaaatcctaa gtggttaaac aaaacatgta taaaaattct gccctctaaa tttatcataa 14940 aatcagttcc aagattttgc aagataatga agttgtacag agtataaagt tatcacatgg 15000 ctgtttctct ctttgcatat gctatgaaag tgtctcccta agaccatcct gatagacatt 15060 gctaggtatg tctgcatcct ctggtgcagt ttcttctgtt gtaggtattc ctagggcagg 15120 ggctttttaa agaagattct gtgtattcta tttaaaaaat atactcaggc catgtgaggt 15180 ggttcatgcg tataatccta atgttttggg aggccaaggc gggaggatct cttgagccca 15240 ggagtttgag accagcctgg gcaacaaagt gagaccctgt tctctacaaa aaattttgaa 15300 agtttgccag gcatggtgct gtgcacctgt gttcctagct actcgggagg ctgaggcagg 15360 aaaatgaggt tacagtgggc tatggttgtg ccactgcact ccagcctggg tgacagagag 15420 agaccctgtc aaaaaaaaaa aaaaaaggaa gtcagtccat ccgtatactg aaggggacgt 15480 gggttttaac ctgagaaatg tgtctcccag ctgattttgg ccattgcggg aagtcatctt 15540 cttggacaag gaagttgttc aggggatgaa tctgggcaag acctaaccct cgtgggggaa 15600 agcagaaggg agtggaatga ttggcgcatc tggagacact ggccagccat tgcctgtgtt 15660 tgaggaagtg ggggcagaac aagaggttat ctggaattcc cacggtaacg gcaaagaggc 15720 aggaggtggg gagcccactg tgttaactgt gttcttcatc tattcaggaa ccgacgagaa 15780 aatactagca aatgtcacag aggatgccaa gaggctgata gctgttgccg actctgtgtt 15840 gacgaaagtt gttggtgacc tcctaagtgg cacgatttta gttggacaac tggagctgat 15900 tataaagcac aagaatcagt ttcttgacat ctggcaactg agtaagcatc gagtcgatac 15960 gcacttcagg ctcctgaggc attaagtagc tggaagacac gtttgtgttt gcgtgtgcat 16020 ttttgtaaag gagataatca tcttagcctt gataatgagt atctcttctt gctcataagt 16080 tgataggggt ggtttataat tctcaagaac atcacgggaa agtgataaaa taatggccat 16140 ctcgaaaaag tgggtatgcg caaaaccatc ctagtccttc tcctggtggc ggggaaggtg 16200 cggcgctttc aaagcattgc catggaaaat ggcatttgtt gctgtattgg gttactttat 16260 tggtgttctt attttccagg ggaaaaaagt ctttcacccc aggatgaaca atgtgctgtg 16320 gaggaagcac tggattggag aagggaggaa ctgttacttc taaagaaaga gaaaagatgt 16380 gttgatagtc tcctgaagat gtgtgggaac gtgaaacatc tgatacaagg tggtattcct 16440 gagaagtgaa caaagttgag ggctctcaaa gggttagagg agaacacagt aagaatggat 16500 cacagtagca gatctttatt ttggagagaa ggctttaaaa tttttttttt aatttgcatt 16560 tgctgggggg atcgctttca cctcttttag attcttcttt ttggtattta tgtccacatt 16620 tccaaataac atgcttaagt gtctcctgga tttttccgga gtcagcatga gctgctgacg 16680 cccgctgcag aagatgaggg cttagagcca cacatttctg gtctgtgccc tgcacacatc 16740 acctttccac ctcctgttgc ttcctgtttt ctcataacgg agttgcatca ttgtttaggg 16800 ttaaatcatc aggacccaca cggatcacaa gtgaaccacg aaagaaaccg tcatcatttt 16860 acaatttttg cacaaactct ctgttttcca cagaattaca tttcctgtca gatgctgttt 16920 tcactgcgtt aatgatacgc tgttttcatt gtattaattt ctaattccat cgcaatctct 16980 gccgagtgtc tgaatttcct tgaagatcat tggtttgacc tttgaaaagg aacctgccaa 17040 ccctgggctg cagacgtagg gtggagtctc cctccacctc ctaggagcct ttgcctggca 17100 cctgggttag acgtggttcc cacgcccccc tcccccgcta ctcactcctg cttcctctgt 17160 tggcagagca caccctcact ggcttcctga gaaaagggcg tgtaagaggt taaaccctcg 17220 aatccttgtg tgtctaaaga tgtctgtcct cttactaggt cagtcgctcg gctaggtcta 17280 gaattacaga ccggaagtca ttttccttct gaagtttcaa tgtgctgcgc catcattgcc 17340 tccacagtgt ggctatgtat ggagaagtcc gatgcagtgc cagttacaca tccttcatgt 17400 gtgtgacctg ttttctcttt cttgaagctc ttgagctctt tctgttactc atattctgaa 17460 ataataacgt gtcttggcct ggatctatgt tccatcgagg ctgggcatgt tggctcccac 17520 ctgtaatccc agcacttcag gaggccaagg caggaggact gcttgagtct aggagtttga 17580 gaccagcctg ggcaacatag caagacccca tctctaaaaa aaatacaaaa aaattagcaa 17640 gacacggtgg tgcatgcctg tattcccaac tacttgggag gctgaggcag gaggatcact 17700 tgagcctggg aagtcgaggc tgcagtgagc cgaaatcacg ccacaacact ccagcttggg 17760 tgacagagtg ggaccctgtc tcaaaaaata aaatattttc agtcccctct attgggtatt 17820 aataggtagg tctttcaact ctagacatca aaatccttga gttctgggaa attctcttga 17880 atgatttaat tttttcttct cttgctggaa ttcctgttaa ttggatatgg gacctcctgg 17940 atgatcatct aactgtcatc atttttctct cggattttct atctctgttt tttgctctgc 18000 tcttgagaga tttattcaga accaaacttt ctgcttaggt tttcatgtca gctttcgtat 18060 atatatttaa tgtagaggaa ttctttttct cggaatgttc ctttttaaat tctgtcctgt 18120 tcttgttcac gttgcagcat cttcccttct gggttattca ccgttttgtt ttggaggttt 18180 tgcttttcct ggcatcatgt gctgcttcct ccaggttcct ttcacttgtt gatttgtttt 18240 gattttcctc ctatgtctgg acattcttgt ttgtctgtgt ttattaagag aaagccctca 18300 caagtgggtt ggccctctgc ggggtgctgc cgtggggtgc tgtggctcga cctggaagtt 18360 ggcctgtctc ctgaagtctt ctgtctcctg cctggagggt gtgggcctgg ctgccaggtt 18420 tctgggagcc aagagggaga agcgggctgg cgggccttgg catcccgtgc gtggtcctcc 18480 catggcccgt gttctcagtg tggttctccg ccacctccct ctgtctcctg tgtttcacac 18540 cccatcctcc ttccccctga gattggataa ttcatgtctt ctgttagctt cctgagaaag 18600 gggatgtgtc tagaaaggcc ctttgttctg ccatgtatct gtggcctcca atccacacgc 18660 ccccctgcgt tatcctttct agaaaatgaa ccatctcttg gctgctgggg tgaagaaggg 18720 ggtccacctg ctgtgtcagg gcattggggt gacagttggt gtgctggatg gaccatgtct 18780 tttttttggg acagagtctt gccctgttgt ccaggctgga gtgcagtggc tcagtctcgg 18840 ctcactgcaa cctctgcttc ctgggttcaa gtgaatcttg tgtctcagcc tccctagtag 18900 ctgagattac aggtgtccac caccacgtcc agctagtttt ttgtattttt agtggagatg 18960 ggatttcatc atgttggcca ggctggtctt gaactcctga cctcaagtga tccatccgcc 19020 tcagcctccc aaagtgctgg gattacgggc gtgagccact gtgcccagcc tggaccgtgt 19080 cttaaacaga ctttgaaccc agtcttcctt atttcatcac cacctcccag tctgcagtga 19140 cctgcacaat gtgtgtctgc tttttgggaa tcctgtgaca taaaactact cagctctcag 19200 tgttgcccac tgggacccta ggactccatg ttaccaggcc tcatgtgtca tttaccactg 19260 gttcagctcg ttttcaactt ctaaaatttt gttcctgtta tcctgttcgc cattcctcct 19320 cctgtccttg tcagtttatg actttttttt ttttttttga tatggagtct cactctgtca 19380 cccaggctgg agtgcagtga cacagtctca gctcactgca acctccacct cccaggttca 19440 agtgattctc ctgcctcagc ctcctgagta gctgggatta caggtgcgct ccaccacgcc 19500 tggctaattt ttgtattttt agtagagaca gggttttgtc atgttggcca ggctgctcat 19560 gaactcctga cctcaggtga tccgcccatc tcagcgtccc aacgtgctgg gtgggattac 19620 aggcatgagc cactgcgccc aactagttta tgacttttta aatgcaattt atgttctgtc 19680 attggagtgg ggtttggcaa agagagtaaa taggtgcgtg ttttcccact gccatcttta 19740 cccagaagtt tatgatgctt tctttatcat gaatattggt taacaaggcc aagcggggag 19800 ggaaagacct gtgaactctt cctgagaaag aaatcctagc agctgtgtgc tcttgagttc 19860 gctcagagaa gtgaggagag aaagtcttag gaaagtgaaa taaaatggaa tcatgattag 19920 agctttgact tctgacactt tcttttcgct tctaaagtgg actttggagt gcttgcagta 19980 agacactcac aagacctcag cagtaaaaga ttaaatgaca ccgtgacagt gagactgtcc 20040 acctcctcga actcgcagag ggcaacgcat taccacctga gctcccaggt ccaagaaatg 20100 gctgggaaga tagacttgct cagagacagc cacatcttcc agctcttctg gcgggaagcc 20160 gcagagccgc tgagtgagcc taaggaggac caggaagccg cagagttgct gagtgagccc 20220 gaagaagaat cagaaaggca catccttgag cttgaagagg tgtatgacta tttgtatcag 20280 ccttcttaca gaaagttcat taagttgcac caggatctaa agtcaggaga ggtcaccctt 20340 gcagagattg atgtcatctt caaggacttt gtgaataaat acacggacct ggattcagaa 20400 cttaagatca tgtgcaccgt ggaccaccag gaccaaagag attggatcaa ggaccgagtc 20460 gaacagatca aggaatacca tcacctgcac caggctgtcc acgcagccaa ggtcatcttg 20520 caggtcaaag agagcctggg actgaacggt gacttcagtg ttctcaacac tttactaaat 20580 tttgtaagtt atttgctggg gactgtgggg gtttggaggg gcgtcctgcc tcagcctctt 20640 caggagccat gggctttgtg gctttgaaaa ggggggcgga tgacttagag cttccgtcag 20700 gggctcctgt gtgtgtggta cttgaggcct gaatatccca agggctttgt ttttaccttt 20760 gttataaata gtaccactgc tccttagcca gagggagttt ccttgggtct gcgtgaagat 20820 caagaactca ggaaagggca acaatcctct tttcataacg ggcatttgta aagggtcata 20880 ggctctctct aggttacaga agccaaaaag caaaacactt tgtcggctgc ccaactgcat 20940 ctcccagttc cacccaaaag cggtaaatca gttgtttctg ttagagttaa gaggtgactc 21000 ttttgctttt ttttttttga gatggagtct cgctctgtcg tccaggctgg agtgcagtgg 21060 cgcgatcttg gctcactgca agcttcgcct cccaggttca cgccattctc ctgtctcagc 21120 ctcccaagta gctgggacca caggtgcccg caaccacgcc cggctaattt ttttggtatt 21180 tttttttttt tttagcagag acagggtttc accgtgttag ccaggatggt ctcgatctcc 21240 tgacctcgtg atccacccac cgtggcctcc caaagtgctg ggattacagg cgtgagccac 21300 cgtgcccggc tgagtcttct gcttcttatg tttttaggta gaccgagata atgattagaa 21360 tttagctggg cacagtggct catgcctgta atcccagcac tttgggaggc tgaggtgggc 21420 agatcacctg aggtgaggag ttcgagacca gcctgaccaa catggagaaa ccccatctct 21480 actaaaaata caaaaattag ccgggtgtgg tgtcaggtgc ctgtaatctc agctactaga 21540 gaggctgagg caggaggatc gcttgaacca cggaggcgga ggttgcagtg aaccgagatc 21600 gtgccactgc actccagcct gggcgacaga gtgagactct tatctcaaaa aaaaaaacca 21660 aaaaaaaaac ctggaatccc atccatttac acttgaaccc tagtgcacgt cctcgaggaa 21720 gcaactgctc tgggccttta ttgacaaagc agaaaaagca acagtagtta cttggcaggg 21780 ttatgtgagg aattgatttt aaaatccact ttattaaaat gcttagcaga atatcaggtt 21840 cccaggaatc acagttcatc ttgatcaggg agaaacagcc atgggggttt gatcatccaa 21900 ttcaggggta agagcttggt gtgcctgttg tcacagcagt ggcaaatcta ggcattgagg 21960 gagggtgggg ctgctgggac ggtcagtgct tgcagctcac agattctggg gttctggtta 22020 atgagttcca gtccacagta gagctttttc ttgcagactg ataacttcga cgactttcgc 22080 cgtgaaacac tggaccagat caaccaggag ctcatccagg ccaaaaagct gctccaggac 22140 atcagcgagg cccggtgcaa ggggctgcag gctctgtccc tgagaaagga gttcatctgc 22200 tgggtccggg aggctcttgg aggtaaaatc agcctttggg gttgcgtgga agtgtggaga 22260 aagttttcag atggcgcact gtgtggcgtt cctaaactct ttggcaatac ctccccttgg 22320 ccaaggacta cgtaaagggc agaaagacgt tgcctgcatg ctttagggag atgggcactg 22380 atcatagagt tcacaccggt acagtatttc ccatgtgctg ctgtaaaagc cactcacctt 22440 gccacacccc gccacttcgg aagctgtaaa tggctcaggt tccttttcct taaaatcttg 22500 cccccttcag ctttttcttc cagtagattt ttactggagg acaaggagag ttcctgccca 22560 cagagaggtt tttttttttt gtttgtttgt ttttttgaga cagagtctcg ctctgtcgcc 22620 caggctggag tgcagtggcg tgatcttggc tcactgcaag ctctgcctcc cgggttcacg 22680 ccattctctt gcctcagcct cccgagtagc tgggactaca ggcgaccgcc accacgcccg 22740 gctaattttt tgtgttttta gtagagacgg ggtttcactg tgttagccag gatggtctcg 22800 atctcctgac ctcgtgatca gcccgtcttg gcctcccaaa gtgctgggat tacaggcatg 22860 agccactgca cctggccttt tttttttttt gagacggagt ttcgctcttg ttgcccaggc 22920 tggagtgcag tggtgcaatc tcggctcact gcaacctcca cctcctggat tcaagcgatt 22980 ttcctgtctc agtctcctga gtagctggga ttacaggcgc ccgccaccac acccagctac 23040 ttttttgtat ttttagtaga gatggggttt caccgtgttg gccaggctgg tcttgaactc 23100 ctgacctcag gtgatccacc catctcagcc tcccaaagtg caggcgtgag caagtacagg 23160 cgtgagccac cgcgcctggc cccacagaga gatttttctc acttctccat tgatgctgtg 23220 cgtttcttgg cagcctcttc agttctgtgg cttagatgtc gttggcagag gagagaggaa 23280 gaggcagagg aggcaggagg ggcacaggtg gcagtgcagg tgtgctcggg ggtctggggg 23340 ccaccacctg ctggatctca ggctctggct ctcttgggag agccgctgct ttcagtggtg 23400 gactctctgg tccacactga tgcacatcct tcagtgagta atttatctga ggggaatgat 23460 ctgagtgttt catagttaat tgtgaacatg ttatttacag ctgagccttg gtttcttttt 23520 gtttaaatgg taatgttgtg tggattgaag gaaagagcat acacagaagt gcagtacagt 23580 gcctgggaca ttgaaattgc tcaggaacgg caagatatcg tttagtgcta ttaacagaca 23640 gtacaggctg ggcgtggtgg ctcacacctg taatctcagc actttgggag gccaagtcgt 23700 gtggatcacc tgaggtcagg agttggagac cagcctgacc aacatggtga aacctggtct 23760 ctactaaaaa tacaaaaaat tagccaggcg tggtggtggg cgccagtaat cccagctaca 23820 cgggaggctg aggcaagaga atcacttaaa cctggaaggt ggaggttgca gtgagccgag 23880 atcatgtcac ttcactccag cttgggtgac agagtgagac tctgtctcaa aaaaaaaaaa 23940 aaaaactaca aaagattagg tgttccggac tcttactgaa agcagaaagt ggacagaacc 24000 ttaaaaattc atgaaatatc catttcagct tcagtaagga ttactgccca agaccgagtc 24060 ttgtgctatc gtggaatagt cccacgctga actcccctct tctcttcccc aggcatcaat 24120 gagctgaagg tgtttgtgga cctggcctcc atctcagcgg gggagaatga cattgatgtg 24180 gaccgggtgg cctgcttcca tgacgctgtg cagggctacg catccctgct atttaagctg 24240 gaccccagcg tggacttcag tgcattcatg aagcatctga aaaagctgtg gaaggctctg 24300 gataaggacc agtacctgcc caggaaactg gtgagtctta ttctgtctct aatgcagatt 24360 ttgttgaata gagcattgct tagcaacgtt agggcagtga ctgtggaaat ggtggcacac 24420 ctgtgtggta ggtttgtaca cagccgtttt caatgatatt taaaaagctt ttcttcataa 24480 atggaaattc accatcttgt tacctagaaa gcaggataca aaattacatg acacatagta 24540 atctctaagg tgcaaaacac acgtggaaaa aagacagaag ggaaatatgc tgaaacgttg 24600 ccaggagttt tctctgaatg gttgtaattg tcattttatt ctgttacttt ttgttatttt 24660 ctataattga tagaattttt tatcagaaaa aagtaaacat ttaaaattag ccaggcatgg 24720 tggtgtgcgc ctgtaatccc agctactctg gaggctgaga cagaattgct tgaacccggg 24780 aggcagagat agcagtgaac tgagatcaca ccactgtact ccagcctgag tgacaaagtg 24840 agactctgtc tcaaaaaaaa gaaaagaaaa gaaaaaagta aacatttaag tttaagtaaa 24900 ctacctgtag cagggtctga attgacgtac gcagcttaac tagatacctg ggccagcctc 24960 cggacggctg ctctgcatgt gggtggagga agaagtgaca tatggaaggg caggtaaagc 25020 tatcttcatt tttctgctag aaagtcagca gagtttccaa acaaaaccct ctgttgtgat 25080 ttttcctaaa cttctcttat tgtacttggg gaccacagaa ggacactgag gacttgggac 25140 tccacagcca ttgcttccag cgtcaccccc agagggttct ctgcattggg gacctggcag 25200 aatgatggcg tctggtagag aggcaggcgg gcggctgctc attcccctcc actcctccac 25260 agatgtaagt caagtgcccc catgtgccag ccggggcacc aggcactgga ggaaacgtgg 25320 aacagcgagt acaaagcagc actgagtgac agatcatgtt gtcagggtgg cacctggtcc 25380 agctggggcg ctgggtgggc gactgcgtcc tgagccctgg ggaagcgtgg ggagaaggct 25440 ctgcagcgag gcagaggcgg gaggccgacc acaggaggga gaagggcaag atcctcgctc 25500 caaccgtggc ccgtgttctc tccttttgtc cccatagtgt gactccgcca ggaacttgga 25560 atggctgaag actgtgaatg agagtcatgg gtctgtggaa cgctcatccc tgaccctggc 25620 cacggccatc aaccaaagag gcatctatgt gatccaggcg cccaaaggtg gccaaaaggt 25680 gagcggtccc cagccctcgg cgcagctgcg gcccttctgc aggctgctgc cagtccaggt 25740 cttctggccc caagaaagtg acttctaacc tatgctcttc acagatttcc ccagacacgg 25800 ttctgcactt gatccttcct gagagccctg gcagccacga ggagtcacga gagtactctt 25860 tagaggaggt gaaggagctt ttgaacaagt tgatgctgat gtctggcaag aaggatcgta 25920 acaacacgga agtggagagg ttttcagagg tgagggcgca tctttgcagt ggcgctaagc 25980 tggtggtgtc atctcgtccg tgagggctgt gtactcccaa gaaaacggaa aggatttgac 26040 ttgggatttg actgataaga agggctctgc tcttaggccc atggagagta gagttggcac 26100 atttgtaggg tgcatggaac tctagtccgc ggccccagag aggtcttaag gcaggcaggc 26160 ccctgggtta gcagtccctc cttacgatcc gtaggatgaa cgctgaagct ggcagcctgt 26220 ccaccgcact gagaaggagg ttggtcaccc agcaaatagc ccttagaaag acacttgaat 26280 tgcctctctc actctgtaaa tcagcaagaa tccaaataac taagatttag atggacaaaa 26340 cagaagtaat catattgaga atggtgtacc ggtctaagta atagtctctc aattttatta 26400 taggttcttt ctctaaagtt gatttgtact ttacaaatgg tatcctttat ctctgctggg 26460 tgcagtggct cacacctgta aagccagcac tttgggagcc caaggtggaa ggctcatttt 26520 agcccaggag ttcatgacca gcctgggcaa catagcgaga ccctgtctca aaaagtataa 26580 ggtttttttt tttcccaatt aaaaaaaaaa gataatttaa aaaaattaaa acagtccagg 26640 catcatggtt cacactttgg gaggccgagg cgggcctatc acttgaggtc aggtgtttga 26700 gaccagcctg gcgatatggt gaaaccccat ctctactaaa attacaaaaa ttagccgggc 26760 atggtggcac gtgcctgtaa tcccagctgc tccggagact gaggcaggag aattgcttga 26820 acccaggagg cagaggttgc agtgagccga gatcacacca ctgcactcca gcctgggcaa 26880 caatgcaaga ctccatctca aaaaaaaatt aaaaaaaaaa aaaaattaaa acaaatgata 26940 ccatttatct ctacaatgac tctttccctg atgagagtgc catcttctca ggtgggttgt 27000 gtagatgagg agggaggcct tgtgagcgca gatcatgcag tgggcctgtg gacagggccg 27060 tcttttggcg gtaggcctgt gtgctgttgc agagtagcgt gttaccctct cgcatggctc 27120 tgtgagccaa cctcatggtt ctgcctctcc aggtcttctg cagtgtgcag aggctcagcc 27180 aggccttcat cgacctgcac tctgctggga atatgctgtt caggacgtgg atcgccatgg 27240 cctactgctc ccccaagcag ggtgtgtccc tccaaatgga ctttggcttg gacctggtga 27300 cggagcttaa agaaggtgga gatgtcactg agctgctggc agccctctgc aggcagatgg 27360 agcacttcct tgacagctgg aagagatttg tgacccagaa gcgaatggag cacttttacc 27420 tgaacttcta cacggcagag cagctggttt acctgagcac tgagctcagg aagcagcccc 27480 cgagtgatgc cgccctaacg atgctatcct tcatcaaaag caactgcacc ctgagggatg 27540 tcttaagggc ctctgtgggg tgtgggagtg aggccgccag gtaccgcatg aggagagtca 27600 tggaagagct cccgctgatg ctcttatcag agttcagcct ggtggacaag ctgaggatca 27660 tcatggagca gtccatgagg tgccttcctg ccttcctgcc cgactgcctc gacctagaga 27720 cccttggcca ctgtctggct cacctggcag ggatgggtgg gtctcccgtg gagcgttgtc 27780 tcccgagagg tctgcaggtc ggccagccca acctcgtcgt ctgtggccac tccgaggtgt 27840 tgccagccgc cctggctgtc tacatgcaaa ccccaagcca gcccctgccc acttacgatg 27900 aggtgctgct ctgcaccccg gcaaccacct ttgaggaggt ggcactgttg ctgcgccgct 27960 gcctgaccct gggctccctg gggcacaagg tctacagcct gctgttcgca gatcagctga 28020 gctacgaggt ggcacgccaa gcggaggagc ttttccacaa tctgtgcacg cagcagcacc 28080 gagaagacta ccagctcgtc atggtctgtg atggggactg ggagcactgc tacctcccct 28140 ctgccttcag ccagcacaag gtcttcgtca ccccccaggc acccctcgag gccatccaag 28200 cctacctggc aggtcactac cgggtcccga agcagaccct gtcggcggca gccgtgttca 28260 atgaccggct gtgtgttggg atcgtggcct cggagcgagc aggtgttggt aaggagagcg 28320 gcagggtggg caggccccgt ctcccaggga ctgcccgggg cccttccccc ctccagcaga 28380 tgaagcctgt ctgcaggtgg agaaaccgag gctcagggag ggtgtgattc atctgtgggt 28440 gtcaatcagg gtctgtgcca gaaccaggca ccctggtcac ctggtctccc acaatgggta 28500 ttccctggga gccccattcc cttcctcctc tcagcaaaca tctctgcagt gtactttgtg 28560 gttttttttt tttttttttt tttttttttt gagacagagt cttgctctgt cacccaggct 28620 ggagtacagt ggcgtgatct tagctcactg caacctccgt tttctgggtt caagcaatta 28680 tcctgcctca gcctcctgag tagctgggat tacaggtacc caccgccatc cctggctaat 28740 ttattttttt ttgttttttg ttttttgttt ttttgagaca gagtctcact ctgttgccca 28800 gattggagta cagtggcgtg atctcggctc actgcaacct tcgcctcccg gattcaagcg 28860 attttcctgc ctcagcctcc caagtagcta ggactacagg catgcaccag tacacccagc 28920 taattttttt atttttagta gagatgtggc ttcaccgtgt tagccaggat ggtctcgatc 28980 tcctgacctc atgatctgcc ctcctcggcc tcccaaagta ctgggatcac aggcatgagc 29040 caccgtgccc ggcctaattt ttgtattttt agcagagaca gggtttcacc atgttggcca 29100 gtctggtctc aaactcctga cctcaggtga tccgcccacc tcagcctccc aaagtgctgg 29160 gattacaggt gtgagccacc acgcccggcc tgaagtttac ttcttctgcc cttaaatgcc 29220 actggcctct ttggggttga tgttggtcgt gtgagcaagg ggaggtagaa ttgaagagaa 29280 agccatgcct cttgacccac ccttcgtttg ccatcttgtt tcccttaaaa agaaatagta 29340 gcttctgttc tgttgacttt atcctatcaa cagtacctcg tcctgttggg ataaacatta 29400 ctcttcccct ccctgctgaa gcctctcctt ttgctgtgac ttttattagc tagtcactca 29460 acacataatg acatttcagt caacagcaga ccacgtatat gaccacggtc ccataagatt 29520 agaaaactgt actttaaaaa ttagccaggc atggtggtgc atgcctgtga tcccagctac 29580 taggaaggct gacttgggag gatcgctcca gcccaagagg tcgaggctgt ggtgagctgc 29640 aaatacgaca ctgcactcca gcctaggcaa cggggcaagg ccttggtctt ttaaaaaaag 29700 agaaagaaag aaagaacaaa agattataat accatatttt ttactgtacc ttttctacat 29760 ttttattttt atttttgaga tggagtctca ctctgttgcc caggctggag tgcaatggca 29820 cgatctcggc tcactgcagc ctctgcctcc tgggttcaag cgattctcct gcctcagcct 29880 cctgagtagc tgggactaca ggcacacgcc accacacctg actagttttt agtagagatg 29940 gggtttcacc atgttggcca ggctggtctc aaactcctga ccttgagtga tcacccgcct 30000 cagcctccca aagtgctggg attacaggcc tgagccaccg tgcctggcct gaatatgttt 30060 agatattcag atatttgccc cgtgtcacag ctccccactg tatgtaggat gcccccatgc 30120 tgtcacggct tgcagcccag gggcaatggg ctattccacc tagctcgggt gtgtggtcgg 30180 ctctaccatc tgggtttctg caggcacact ctgatgttca cagtgacaga atcatttcac 30240 aatgcatttt tcagaacgtg tccctagtgc taagtggcgc gggactctgc tttgcctgct 30300 gtcctgcgga ggcaggaggt gaccaggaga gtgagtaggt aacggctggg aaatgtgaag 30360 gttcaagagc gtattcttga atctgatgtt atgttgcatc agttttgaat tttatacaaa 30420 gagaagtaac ttctagtgga tctttataga ttctcttact ctttgtccta gccctgggac 30480 ttaatttttc tctctctctc tctctctatt tttatatata tacacacaca tgctgtatat 30540 acatacacta tatatattcg atacatattc tatatagatt tctatatata ttctatatat 30600 ttttacatat ataatatata ttctatatac ttccatatat actatatata ttctatatat 30660 acatatatag tatgtatata tatattatat atatattgta tgtatatata tattatatat 30720 atatattttt tgagacagag tttcgctctg tcaccctaac gatgacaact gcaccctaag 30780 ggatgtctta agggatgccc aggctggagt gtagtggtgc aatctcagct cactacaacc 30840 tccgcctccc gggttcaagc gattctcctg cctcagcctc ctgagtagct gggattacag 30900 gtgcctgcca ccacgcctgg ctaatttttt tgtattttta gtagggacgg gatttcacca 30960 cgttgaccag gctggctttg aactcctgac ctcaagtgat ccccccgcct cggcctccca 31020 aagtgctagg attacaggtg tgagccacca ctcccagccc taatttctgt attaatgtta 31080 taggaaagtc tctgtacgtg aagaggttgc acgacaaaat gaagatgcag ttaaacgtga 31140 aaaatgtgcc tctgaaaaca attcgactga tcgaccctca ggtggatgag agccgagtcc 31200 tgggcgccct gctgcccttc ctggatgcgc agtatcagaa ggtccccgtg ctctttcacc 31260 tggacgtgac ctcctcagta agtgccctcc agcgtcagcc gatggccaca tcagtaaaga 31320 cgtggtcccc atgtctctgc gtgactcctc cccgtgtata gaattccttg tttccacacg 31380 cacagtcctg tgaagcttaa cagtgggaat gtgctctgag aagtgtgttg tcaggcagtt 31440 tcctccttgt gtgaacgtca tggtgtgcgc ttacactaac ctagacgtag agcccactgc 31500 acacacaggc tttatggtac acactgtcgc tcctaggccg caaacctgtg ctgcatatgg 31560 ctgttctgaa tcctggagcc aattgtaaaa cggtgtattt atgtgtctaa acataaaaat 31620 ggtacaggga aatatagtat taggatttta tggggctgcc cttggagaca tgggccgttg 31680 ttggctgaaa tgttgatgtt gatcatcagg atcatcgtga caaagagcaa aataaggagg 31740 ggttacttag agttgggaga actcgccatc gtgtcgtgtg tttacacctc gtgcgattct 31800 gttcttaggt gcagactgga atttgggtgt ttcttttcaa gctcctcatt ttacaatact 31860 taatggatat aaatgggaaa atgtggcttc ggaacccctg ccatttgtat atcgttgaaa 31920 tcctggaaag gaggacgtca gtgccgtcga ggagctcttc agcgctggtc tgtactgtgg 31980 ggcgttttcg cctggcgtgg ggggctcttg ggttctttct ggtcttactg aagtggaatg 32040 gcgcgtttag gagactccac atctttgcct tacttagtgc agcagctgaa tgcagtgtta 32100 gtaaagaaaa gcccatcttt aaactcactt tttaatcatg tctgggataa aagtactctt 32160 ctgttaatta gcagtgtctt caatatttct gttcaattca ggcttcatgc tgtatgccca 32220 gtctgaatcc cagctgtgct ctgaatctag gaaattcatc tgttgaaaga cctcaccttt 32280 cctaatgcca gctaagatga gaaggagatg tttgtcaaaa atttcttagc aaaagagagt 32340 tttatgttca ctcacataca taatacatgt atagcttagt ggagaaactt agtttcagga 32400 agttgggtta gaaagtgatt tcctggctca gaacgcagct cccacagcaa tgccttactt 32460 aatgtgcaaa agatatgctg tggaaaaaaa gactatacag aaagctacat attttcagtg 32520 cgtttttcat aaaggtccat ccaatataga taacgtggag ggttaagaca caaaagcatt 32580 tcttagaaag tcttcttgta accatttcat taatgtctct cctttccagc gtacacgtgt 32640 accccagttc agttttcttg acatcttccc aaaagtcacc tgcaggcctc ccaaagaggt 32700 gatagacatg gagctgagtg ccctgaggag tgacacagag cctgggatgg atctgtggga 32760 gttctgcagc gaaactttcc aaagacctta ccagtattta agacgattca atcaaaacca 32820 agacctagac acgtttcagt atcaagaagg ctctgtcgaa ggcaccccgg aggaatgcct 32880 ccagcatttc ctgtttcact gcggggtaat aaacccatcc tggtcagagc ttcggaactt 32940 tgctcggttc ctgaattatc agctcagaga ttgtgaggcc tctctcttct gcaatccgag 33000 ttttattggc gacacactga ggggcttcaa gaagttcgtg gtgaccttca tgatctttat 33060 ggcaagagat tttgccacac catcactcca cacctctgac caaagcccgg ggaagcacat 33120 ggtcaccatg gatggggtta gggaagaaga tctagcgccc ttctccctcc ggaagaggtg 33180 ggagtcggag cctcacccat acgttttctt caatgacgac cacacaacca tgacattcat 33240 cggcttccat ctgcagccca acatcaacgg cagtgtcgat gccatcagtc acttgactgg 33300 gaaggtcatc aagagagacg tcatgaccag ggacctgtac cagggcctgc tgctccagag 33360 ggtgcccttc aatgtcgact ttgataaact gcccagacac aagaaacttg agaggctctg 33420 cctgacctta gggatccccc aggccaccga ccccgacaaa acgtatgagc tcacaaccga 33480 caatatgctt aaaatccttg ccatcgagat gcggttccgg tgtgggatcc cggttatcat 33540 catgggagaa actggctgtg ggaaaaccag gcttattaaa ttccttagcg acctgcggcg 33600 tggtggtacc aatgctgaca ccataaagct ggtcaaggtg cacggaggaa caactgcaga 33660 catgatctac tccagagtca gggaggctga aaatgtggcc ttcgccaata aggaccaaca 33720 tcagttggac accatcttgt tttttgatga agccaacaca acggaagcta taagctgtat 33780 caaagaagtc ctgtgtgatc atatggtgga tggccagcct ctggctgagg actctggcct 33840 gcatattata gctgcctgca atccataccg gaagcactct gaggagatga tctgccgttt 33900 ggagtcagct ggtttgggct acagggttag tatggaggag acggccgaca ggctgggctc 33960 cattcctctg aggcagctgg tataccgggt ccatgctctg cccccgagcc tgattcctct 34020 ggtgtgggac tttggacaac tgagtgacgt tgctgaaaag ctctacatcc agcagattgt 34080 ccagagactg gttgagtcca tcagcctaga tgaaaacggg actcgcgtga tcacagaagt 34140 cctctgcgcc tctcagggtt tcatgaggaa aacagaagat gagtgcagct ttgtcagcct 34200 cagggacgtg gagcgctgtg tgaaagtttt caggtggttc cacgagcaca gcgcgatgct 34260 cttagcgcag ctgaatgcct ttctctccaa gtccagcgtc agcaaaaatc acaccgagag 34320 agatcccgtc ctctggtcgt tgatgctggc catcggggtg tgttaccatg cctctttaga 34380 aaagaaagac tcatatcgga aagccatcgc caggttcttt ccgaaaccgt atgacgacag 34440 caggctgctt ctggatgaaa taacacgggc acaggatctt tttctggacg gcgtacctct 34500 gaggaaaacc atcgccaaga acttggcctt gaaggagaac gtcttcatga tggtcgtctg 34560 catcgagctg aagattcccc tcttcctggt ggggaagccc ggcagctcca agtctctcgc 34620 caagaccatc gtggcagacg ccatgcaggg cccggctgcc tactcagatc tcttccgcag 34680 cctgaagcag gtccacctgg tgtccttcca gtgcagcccg cactccaccc cacagggcat 34740 catcagcacc ttccggcagt gcgcccgctt tcagcagggg aaggacctgc agcagtacgt 34800 ctctgtggtg gtgttagatg aggtggggct ggcggaagac tcacccaaaa tgcccctgaa 34860 gactctgcac ccgctgctgg aagacggatg cattgaagac gatcccgccc cccacaaaaa 34920 ggtcggcttc gtgggcatct ccaactgggc ccttgaccct gccaagatga accggggcat 34980 ttttgtgtca cgtggcagcc ccaacgagac agagctcata gagagcgcca agggcatctg 35040 ctcctcagac atcctcgtcc aggaccgagt ccaagggtac tttgcgtcct ttgccaaagc 35100 ctacgaaacg gtgtgtaagc gccaggacaa ggaattcttc gggcttcgtg actactacag 35160 cctcatcaaa atggtctttg ctgcagcaaa ggcttcaaat agaaagcctt ccccgcaaga 35220 cattgcacag gctgtcctta ggaacttcag tggcaaggat gacatccaag ctttggacat 35280 ctttctggcc aatttgcccg aggccaagtg ctcagaggaa gtcagcccca tgcagctgat 35340 caaacagaac atctttgggc cttctcagaa ggtgccgggt ggagagcagg aagatgctga 35400 gtcccgctac ttactcgtgc tgaccaaaaa ctacgtggca ctgcagatcc tgcagcagac 35460 attcttcgag ggggaccagc agccggagat tatttttggt tctggtttcc ccaaggacca 35520 agagtacacc cagctctgca gaaacatcaa tcgtgtgaag atctgcatgg aaacaggcaa 35580 gatggtgttg cttctcaacc tgcagaacct ctacgagagc ctctacgacg cactcaacca 35640 gtactacgtc cacctcggcg gccagaagta cgtggacctc ggtctgggga cccaccgcgt 35700 caaatgtcgg gttcacccca acttccgcct gattgtcatt gaagagaaag acgtcgtgta 35760 caaacacttt cccatccccc tcattaaccg gctggagaag cactatctgg atatcaacac 35820 ggtgctggag aaatggcaga agagcatcgt ggaggagctc tgtgcgtggg tggagaagtt 35880 catcaatgtc aaagcacatc atttccagaa gaggcacaaa tacagcccct ctgacgtctt 35940 catcggctac cactcggacg cctgcgcgtc tgtggtgctg caggtcatag agaggcaggg 36000 tccccgggcc ttgacggagg aacttcacca gaaggtgtct gaggaggcca aatcgatcct 36060 gctgaactgc gctacgcccg atgccgtggt ccggctgagc gcctactcgc tgggcgggtt 36120 cgcagcggag tggctgtcgc aggagtactt tcacagacag aggcacaact cctttgcaga 36180 tttccttcag gcacacctgc acacggcaga cctggagcgc cacgccatct tcacagaggt 36240 gattgtcttt ctgcacttgt accctatccc ctgtcaccca agagtcctaa atccctcgtg 36300 tcaggattca agattcttcc ccaggcagcg gttagggatc ctgcagggag atgctgagac 36360 gctgagctct cctccgcggt aagtgtgggg agtaggtcca gttaaccagg tgctgagtgc 36420 ctggctctgt gcagtgcacc atgctggtaa cagcaccata cacagtgttc acaccaacaa 36480 ataaagtacc acgtcccagg actgggccaa gggcactagg gacgcacaga tgaatctgta 36540 gcccttgtcc tttgttagca ttagggagca tggagagacc agcacatgaa cagatgccat 36600 caatatcata tgataaatgc tgtgcttaga ggcagcgggg agcggtgcag accaggatgc 36660 gagctcagat gagatgttcc ctaggagaag cccctcgccg atggggaaga atggccggga 36720 agggattgta ggctgagggc cttctgtggg cagagccgct gacagctctt agggttcaag 36780 gctgtagtgc tgagatgggg cgatgaggtg cagtcagaga gaactactgg aggccctcag 36840 tgactctgca gagccacatc tcagccctat ggagcgggca ctggaggcac gcttgtctcc 36900 ctggctgggt gaagggagtc tgatgaaagg ctgttgtgga aaagacgggc cggtagggag 36960 gccgctggaa ccgtacaaag gagaggagca gatggaaccg agagatactc aggaggcaat 37020 ttggcagggc caataccacc acccagtggg gggatggggg gtggaggggt ccggggcgac 37080 cccctggatt cctccttaga tgagtggaca ttgcttcatc atgacagata ccgcaggaac 37140 ggacagcagg ttgtgggagg ctagtgatga tgtccgccgg ggacaggttt ctatgcatcg 37200 tgcagctgga cgtaggaatc tgagctcagt ggtgaggcag ggattcctgg gctagagcag 37260 caggcctcga ggaacgtttc gacttgcact gtgatggggg agtgaccttt gggacaggag 37320 aattgctgac atctggggga aggggacagc accaaccacg aactccatct gaaagcatga 37380 gtcgtactat aacaggaaat ggcatttgtg ctgagcccta agggatcatg agaatctcaa 37440 gtacggacca agcaggcaga gacacgggcc tctggggagg agaggaaggc accctcgggg 37500 cagggtgggg tcgtctctcc aatgcctttg gccctgtagg gcctctcggc cccagcgctg 37560 ccgtgttttg ggaaactcct ttgggtttgg attctgtgcc gttgtgtggc aactgcaccg 37620 cgctgaacat cgcaggtttc taggatctgt ctaaacctgg cagcagactt gcaacctttc 37680 cttgaagtct ggcaagtaat ttgcatttct taactctgta gatcaccact ttctccaggc 37740 tgctaacaag tcacgactgt gaaattttag aatcagaggt cacaggcagg gctccgaaac 37800 ccacactcct gtggctgcag cagtttgaca ccgagtactc attcctcaaa gaagtccggt 37860 gaggttccct gccttccctg ctgccctctc cctccccagc cgcagccgtg tggcttctgc 37920 gtggcgatgg tacccgcgcc ggttaatgag cgccacagtc acgtgactgt gaaatagatc 37980 cttgttaaat ctctcccagc atccctctca tctccatcat cttctgcaac gcggtgtctg 38040 gcctaacatc ctcctccgag agcaccatcc tcggacctcg ttaggaggca ttccttgggt 38100 ttcctcccct ggactatctg ttcttactga agaaaatcct acctgagtag ctgtttcttt 38160 gtagccttta tgtttcccat cactttgggg aattttcttt tccatttttt taagacagag 38220 aactcacttg aataacttcc cttttctttc agaaactgtt taacgaatac agccaaatgt 38280 aaaatcctca tttttcagac agattttgaa gatggaatcc gtagcgccca gctcattgcc 38340 tcagctaagt atgtttttag tatttttctc agaaactatg taaaaaaccc aaaacgtagg 38400 aagtcctaga gaattttttc cttgaagaca gtatagtatc ataatcagta tagaaataaa 38460 aataacaatt cttcccccgc ctcattcccc caagtgggat tagggaaact gaagagagac 38520 aaaaagaaaa ggccaataac attacaaaaa tagtggaatg ggcctgggca acagagcaag 38580 acctcatttc taaaaaaata aaataattag ccttccacag tgcacctcta gtcccagctg 38640 ctcagaaggc tgaggtggga ggatcgcttg agcctgggag gtcaaggctg cagtgaactg 38700 cgatcccacc actgcagtcc agcctagggg ccagagcaag agcctgtcct ccccacaaaa 38760 aaggtgaaat gcgagaggtg taaataatgg aacattaaca agctataaaa ggatgccttt 38820 gaagcctgtg tttgtagaca tgttttggtc attattaatt ttgaattata caatttgaat 38880 ttatttcaag ttcgagggaa acaacagtag gtaaatgctt tttttcctat ttattggata 38940 tttttatagt gtttgtaggg gaagtctgat gctcttagaa ttaactttgt gcctttatta 39000 cttaaagtaa aagtgatttc tggacctttt tgaagcattg gatgccatat ttcagttcgt 39060 ggcttaaatc tcaacaagaa actggctttg gccattggtc atctgaaggg aatggcattg 39120 cgcacagaac tctttgttga aatggaaagg tccactgggt acaggggctg tttcctgtaa 39180 tcctagctac ttgggaagca gaggcaggag gatcgtttga ggccaggagt ttgagaccag 39240 gctgggcaac acagcaagac ccccatcgct taagagaaaa gaaggaatgg aaagttcagc 39300 tgtcctcacc cttagctgca ccggggcagg cccattgagg agcacaagat agggtttctg 39360 gtcaacgaag gaatgccact tcaaagcaga ggacacagga atggggaaga aaacgagccg 39420 ctaagagaag atttctcatc cccttgtgag agaagaaatc acgatcgcag ggctctgaag 39480 tttatgtaaa actcatcgga acgggtggcc gtgagaccga accaacagct cggagaacac 39540 ccttctgcag ctgcacagct ttgctttgtt tatttgcttg tttttgtgtg tgtgtttgtt 39600 tttaaaatag gtattctttt ttttttcttt aaataggtat tctgttataa atgaaatcaa 39660 caaaatacga gaaaatgagg accgtatctt cgtctatttc atcacaaaac tgtcccgggt 39720 gggaagagga acagcctatg tgggcttcca cggaggtgag atcagaacat cagtcagggt 39780 atttatttat gtatttattt atttatttgt atctatttat tttttgagat ggagtcttgc 39840 tctgtcacca ggctggagtg cagtggcgcg atctcagctc actacaacct caatctcctg 39900 ggttcaagcg attctcctgc ctcagcctcc caagtagctg gcattacagg cgtgcgccac 39960 catgcccagc taatttttgt atgtttagta gtgacggggt ttcaccacgt tggcctagat 40020 ggtctcaatc cgttgacctc atgatccgct cgccccagcc tcccaaagtg ctgggattac 40080 aggtgtgagc caccgcaccc agcccagtca gtgtatttat ttaagtcatg ttggaactgt 40140 ttctcatttg gttctgtgtt gtacagtctg aaattagaat attattgtta acctcaagag 40200 gattctttcc agatgcaatt agatttctta ccactgatta ccatgaaaac atgaatcctg 40260 ggatgggagg ctgcgtgcac ctctcctgga ctgactctag gcaagctcct cacctcttag 40320 catgtaggtc acacggcgtg gagactcccg actcccgaca gacactgtca ggaacgcacc 40380 gatacgcctg tttggcgggg agggagagtg gcgggggtcg gactatcttc agatctcttt 40440 ttttccaagg aatggtcacc agctatttat gacatagaaa agttggtatt ccagaaacag 40500 gaaagtaagt ttacttgaat aatttcgtgg agaatggaag gcagaccttg ccagtgtccc 40560 ccacccctca ctaactgtga tacagcaaat acaacaatgc atgggtgaaa gaaccacagg 40620 ccttatccat gcgtccttcc cacgctggcc attgcaggtc ttaccgttgc tgcttatggt 40680 gaagctgtcg atgggcatag aatcgggtcg tgtatagtat cgggttgggt ggtttctgcg 40740 caggcccatt ccagggtttc ggcttcaggg tgccagtcat tcattgcgca gcaagataat 40800 gacaagccag ggtgtgcaat gtccctgctt agggctgagc agcagccggg aaagacacaa 40860 agacagttgt gggtggcttc actcttcaca gggctgtggc agtctgtcca catcgatgac 40920 ctccggagat ccaccctcat ggtttctgat gtgaccaggc tgcagcatgt caccatcagc 40980 cagctgttcg cgcccggaga cttgcctgag cgtgagtcac gaggcggagc ccctggggga 41040 gcaggtggtg gaagggcaga tggcaggtgt ggagcgtggc gtgcacatgg cactaggagc 41100 agggccaccg tgtttcgtcc ctcggcagga gctcggggac acatctgcag aactgactgg 41160 tggctcatca tagagcacca gggccgagca ggtgcgctta ccacaggctg aggtagagct 41220 ctgtgagcag gccagccatg gaagtgagca cctagaacac gccagagccc aggctggaag 41280 gaaggggctg ccttgggggc tgatcttcat gaccgtgatc tctcatctgg ggacctagca 41340 ccacagcagg ggccggggaa gcctgcactc ggaggctgag cacacagact cccagatggc 41400 accgctgcca gtccctgtgc caccttctga gtggtaacgc aatcacgttt gcttcgactg 41460 cagtgggctt ggaacaccgg gcggaagacg gccatgagga ggcgatggag acggaggcca 41520 gcacatcagg ggaggtggca gaggtggcag aggaggccat ggaaacagaa agttctgaga 41580 aggtgggaaa ggaaacctct gaactcggag gcagtgatgt aagttctggt tcttgggacc 41640 tccccttgtg ctgctggtga tgcttctgag ctgcatcttt aaacgctttt gcattgggag 41700 ctagaggagt cgccgccgct gtgcaggggt gaggatggcg ccccactttc ctcacacagt 41760 gacggtcttg ttgctggtta ctgggggtca agggcatctg caccggcagt ttggggggtg 41820 cagggcggag gtcggcgtct cttctttgtc cgtgaggacc gccgccctgt gctgtttgct 41880 gcattgagac cctcatcgca tacgggcggt ttggcttttg cccactgtgt cagtggcaga 41940 aacggatgac ccaaccgtct ccaccaacag gtgtcgatcc tggacaccac caggctgctg 42000 agaagctgtg tgcagagcgc cgtgggcatg ctcagagacc agaacgagag ctgcacgcgc 42060 aatatgcgga gggtggtgct cctcctgggc ctcttgaatg aggatgacgc gtgccacggt 42120 atgagcctcc ccacccctct tgcccctgcc cccacgtggg ctcttcctga ggagtgggca 42180 tcatttcact gtgtgttggg ggacaccctc tcaggtttcc atggctcagc agaagcagtg 42240 acacagtggg aatctaagag catctctcag attttgctct agaattggcc tggccaacgg 42300 acttcccttc ctgggggagg tgggacagaa gcactccgga gccaacagct cagccacggc 42360 catgctgaac gtctgtttct gcctttgtac agcctctttc ttgcgggtat ccaagatgcg 42420 cctcagtgtc tttttaaaga agcaagaaga gagccagttt caccctctgg agtggttggc 42480 aagggaagcc tgcaaccagg acgctctcca ggaggcgggc acattcaggt actgtgacta 42540 aaggaagcaa ggagtggctc caatctggtg gcagcatggg gacctgcctg cagggatcct 42600 ctctccatcc gggccatggg gactgagctg tttctttcca aacctctcag ccattcaaag 42660 ctgtaaagtt tttccccaag aagcacacag taggtctgga cagtggccaa atggcaggtg 42720 ctggactctt cctctaattt cgtgtttaca gtttttcata ctaaaaactt aaaaaaagta 42780 aaacatctgt tcttagagta gaacatttac cgacattcat gttgataacc ctagaaaggg 42840 ctgctgtttt cagtcatgaa gttaaaatga cgtgcagagc aggcagggga caggcgggat 42900 tttcccagtc ctgctgtttg aagaatggta acagcaaaac caggacccag cagtatattc 42960 actgccatgg ttatttttct gtcacccatg agactaacct tgattatctt ggatgtggcc 43020 gtgtattgag gaaggagggg tgctctgggc cccagacaga gggtctcttt aagacagact 43080 ctcagacctc ctgcctgaaa gcctaagaaa ccagtgactt ggttatttgg gcccagtttt 43140 cccatctcta aaagacagcg gactcctcca tgagtcccct tccaggtcca agcttctgtg 43200 ccagtgatag gttcgctttg ggcctacagc caggtgtgat ctgcaggagg gaacgtgagg 43260 aagaagcggg gtgaacggta atgggggctt acaggggaag aagcggggtg aacgggaatg 43320 ggagcttaca ggggaagaag cggggtgaat gggaatgggg gctcacggag gaagaagcgg 43380 ggtggatggg aatcggggct cacggaggaa gaggggtgac cgggaatggg ggctcacaga 43440 ggaagaagcg gggtgaccgg gaatgggggc ttacaggggg aagaagcggg gtggacggga 43500 atgggggctt atggaggaag aagcggggtg agtgggaatg ggggcttaca ggggaagaag 43560 cggggtgagt gggaatgggg gcttacaggg gaagaagcgg ggtggacggg aatgggggct 43620 tacaggggga agaagcgggg tgaccgggaa tgggggctta cagaggaaga agcggggtgg 43680 acgggaatgg gggctcacgg aggaagaagc ggggtgaatg ggaatggggg ctcatggagg 43740 aaaaagcggg gtgaccggga atgggggctt acaggagaag aagcggggtg aacgggaatg 43800 gggacttaca gacaccttcc tcgtgaccag agattttctg attctacttt ttctctagtt 43860 atccttcgtt tctctccttg tcacgccttc tgaagggatt ttaggagatc agaaatattt 43920 tcatttccct ccgttcctcc ttgtggactc tcttgatgct tttttttttt tgagacggag 43980 tctcactctg tcgcccaggc tggagtgcag tgatgcgatc tcagctcact gaaacttcca 44040 cctcctgggt tcaagcgatt ctcctgcctc agactcctga gtagctgaga ctataggcac 44100 ccaccaccac acccagctac ttttggtatt tttagtagag gcgagatttc accatgttgg 44160 ccaggctggt ctcaaactcc tgacctcagg tgatccactc gcctcagcct cccgaagtgc 44220 tgggattcca ggcgtgagcc agtgtgcccg gcctgttgat gcttttgaat ccctgactcc 44280 actccccggg accagccctg agtcactgaa cctcctcagt ctgctcttcc ccactctgct 44340 gttcacgcag cactaggcct ggctccgtcg tgttctgtgg tcaccgtgag gcctgcgcag 44400 ccgctgagtg gtggccagac ccgcaccctc agctcacctg ccccagggcc agcagcaccc 44460 tgactacctc gattcaccac cactgtgttc tggggactgg agtcctttgc cctctcggga 44520 ttaaacagcc caaatcctga gagtcctttg tgtcccgaac tctgcctgcc tgtccagata 44580 cagcagaacc aggctcagcg gctccagata gggcggaacc aggctcggcg gctcccgcct 44640 ctcccagcgc ttgtcccagc gcctgggttt tccttctgcc ttttgtgttc gcgacacttt 44700 tcctagtttg ctgttttctc cctctgtgca ctgggatgct ttattttccc aatagacatt 44760 ttaaaattct tgccaggttc ctctgtacta tatatttaaa aaatgtaggt atttcttttt 44820 attctcttca aaagagaggc ttcgcttttc ccccaacatt aattaccttg tggggttttt 44880 tttttttcga gacagagtct cactctcgtc ccccatgctg gagtgcaatg gcgcgatttt 44940 ggctcactgc aacttctgcc tcccgggttc aagcgattct cctgctcagc ctcctgagta 45000 gctgggatta caggtgcctg ccaccacgac tgtaattttt gtatttttag tagagacggg 45060 atttcaccat gttggccagg ctggtctcga actcctgacc tcaggtgatc cgcccgcctc 45120 agcctcccaa cgtgctggga ttagacgtga gccaccgtgc ccagccacct tttaattctt 45180 atcctttaca caagaatttt gaaatagagc tattattgtt acatgtaaat atatacaaca 45240 aaatatatat aacaacaaaa tgtcttgtag ttaaccaatt atctttctgt ctgcctatct 45300 gtgcattcat ccatccctcc gcctgcctgt ccatccaccc atctgtccgt ccgcccatct 45360 atccatccac ctgtctatca gacactcaga tctagtgtac aaaaacatca acaggaacaa 45420 atacttagtt ccagataaac atgtgccttc ttgtttagtt tgatctggga caaattcatt 45480 ttggtctctt catctgtatt atagtctatc tacaacagat ttttaaaata tttatttttt 45540 ccaaatgaat cgtcataatt ttatttattt agagaacctc gatgacttgt tctgaaaaat 45600 agttacatac aaaaattatg cagccttgca aaaaataaag cagataagtg cggtggctca 45660 cacctgtaat cccaatactt tgggaggcca aggcgggagg attacttgtg cccaggagtt 45720 tgagaccagc cagctagggc aacatagtga gaccccatct caacaaaaaa taaaataaaa 45780 tttaaaaatt agctgggcat ggtggcactg ggtgtgttgt tcctgtctac ttgcacggct 45840 gaggtgggag gatcgtttga gcccaggtat tccaggttat gacgatctat gattgtgtca 45900 ctacaccgca gttggcgtga cagagtgaga ccctcacata catgttttaa aaataaaaaa 45960 gcaaacacta cttcaccctt ccagtaacct aatgacagtt tattagatgt agaattaagt 46020 tccattccag ttccgtctct aatcttagac atctttgtga gtctgttttc taggacttaa 46080 aaatgatgga aatgtcaagt tattgctgtc gctgtagtgt ggtaaatagt agactagttg 46140 ttttgttaat gctcaagaag gaacaaaatg tcaaaaggtg gcagaccgcc actctggttc 46200 ctctgacccg tggtggccca tctctcttct gtgctgcagg cacaccctct ggaagcgggt 46260 ccaaggtgct gtcacccctc tgctggcgag catgatatca ttcatcgaca gagacggcaa 46320 cctagagtta ctgaccaggc cagatactcc gccctgggca agagatcttt ggatgtttat 46380 tttcagtgac acgatgcttc tgaacattcc tcttgtgatg aataatgaaa ggtgagtgga 46440 aggctttctt tccctgggga gagaaactat cagaacacag caggacccta atatgctctc 46500 ccaagtgctg ggtgaaacgc agccctcaac ttcagagcaa cgttgacatg ggtgctttct 46560 gcagtaacaa taggaagttt ggccgggcat ggtggctcac gcctgtaatc ccagcacttt 46620 gggaggccga ggcaggtgga tcatgaggtc aagagatcaa gaccgtcctg gccaacgtgg 46680 tgaaaccccg tctctactaa aaatacaaaa attagctggg cgtggtggcg cgtgcctgta 46740 ttcccagcta tttgggaggc tgaggcagga gaattgcttg aacctgggag gcggaggttg 46800 cagtgagccg agatggcgcc actgcactcc agcctggtga cagagcaaga ctctgtctca 46860 aaaaaaaaga ataggaagtt tacgaagctc tgagaaattt ctgttttatc tccaccctcc 46920 tcatttccct gctttcagag cactggttct agccagaccc agcatggcgt gacacggaga 46980 cagtgcgctg cgaacagccc cacaatctgt gctccttacc cctgggatct gtgctccctc 47040 cccgtccctc attccctggt ggagcggcac agcccccacc cccttccgca ggcctgatga 47100 tgtgcggctc aggctcagct cccaatagct tccacttcag ctttcagggg cttcaattct 47160 ggatgtagat ttataaagaa tatagaaata aatgtgccca ggctcggtgg ctcatgccta 47220 taaccccagc aatttagtag gctgaggcag gaaagtttct tgaacccagg ggttgaagac 47280 cagcttgggc aacatagtga gaccccatca ctacaaaaaa tttaaaaatt aggcataacg 47340 tggtgcgcac ctgtagtccc agctactcta gaagctgagg cgggaggatt gcttgagccc 47400 aggagtttga ggtgagatag gatcacacca ctcactgcac tctagcctgg gtggtgacag 47460 agtgagactc tatctcaaaa aaaaaaaaaa aaaaaaaaaa aaaagagtga gagagggagg 47520 gagacagaag gaagaaagag aaagaaagag cgagagaaag agagaaagaa agtaaagaaa 47580 gaaagagtga gagaaagaaa gaaatggaat ttgaattgcc agtggaaaca cttatttaaa 47640 agacaaggcg ctgctgatgt tcatgaagca aagactctaa caagttgtgc tctgtgttac 47700 aagttatcaa agccagacag gttcaggaac cagaagactt ggttctgccc gagattttgg 47760 gcaacacact tgacccctgt cagccttggt ttgtttttgt tttgcctgtg aaacaaagat 47820 tgcataagac agttccctag ttctgtcata acagaaaccc tgtactgtga aacagatcag 47880 cgccgtctgc ctggcctgtt ggcccctttg tttttgaggt ctgagaagag ctggcatcag 47940 tggcagatct tatcttgtgt tttgagtgac gtctcacaaa ccctcttctt atcatccctc 48000 accttattgc agacataaag gtgagatggc ctacatcgtg gtgcagaacc acatgaacct 48060 ttccgagaac gcttccaaca acgtcccttt cagctggaaa atcaaggact atctggagga 48120 gctgtgggtc caggctcagt acatcacaga cgcagaaggt gaggctacct caagacaggt 48180 cagattcagc acaggtgaat cacaaaggga ttgcctgaca gtgaaaagca gatgggtggc 48240 tagaattgca aggtgaattt tggagttttt agttttcaca ctttgtttgt gcagtaagcg 48300 tccaatttac gtcaccgcgt cattttaaag tttctgctga aggagtgaga ggccccggcg 48360 ggaccagaaa cctttcgatc ctatggcagc aggagcctgt gagatggttt ttagtgccgt 48420 gatggccagg gatatggcga aatggggtgt gttctggcaa gaggaggact gtcgcctcta 48480 tcagctggtc attcccattc tgggccttct cagactgggg cactggactc ggaagatgcc 48540 cccaggagag gcgttctcag aaggcacgag cgcctggagc atcccctact cccaggtgcc 48600 ccatcaggag gcacctccca gctgtgtctc ccgagtcaca gcccagacac agtgctgagc 48660 tctgctgcca gatgccagaa gatttgccct agtccagaaa aaccaacgac aacgcaacac 48720 ttttacaaaa gccatctttc atacatgcaa tagtcttttc cacgtttact tatcgtacca 48780 tttggaagac tcagggtggc cttcttttct aggttaccat tctgccactt tttctcaaag 48840 cagtctctct cctcatgagc atattccttt ctcaggacaa taccccaact gaccctgctt 48900 ttctatgaca gcatgcgaat taggggctgc accccgccca ctagaagcca gatctttctg 48960 gcttgcatgc tctgtgaccc ccagcccctg aagagcagcc cacttgttcc taatttactt 49020 ggacccgggg gttcctgaag catgctgtga cctgtagcca tgcaacatac aatgtagcca 49080 tgcaacatac aactcagtct tatctagatg tttctctttg gggctagctt ggctgtttct 49140 gacctaaatt tgacactgtt tccgccttcc tttattttat tccactggaa aaatatccta 49200 ggccaggcgc agtggttcac aacaccttgg gaggccaagg ccggcagatc acctgaggtc 49260 aggagttcga gaccagcctg accaacatgg tgaaaccccg tctctactaa aaatacaaaa 49320 aattagctgg gtgtggtggt gcatgcctgt agtcccagct acttggtagg ctgaggcagg 49380 agaatcactt gaacctggga ggcggaggtt gcagtgagca gagatcacgc tacccaccgc 49440 actccagcct gggcaacaga gtaagactcc atctccaaaa aaaaggaaaa agaaaaatat 49500 cctaaatgtc tagacagtga ctattccttc aattccctac aaaatcaggc agttggtacc 49560 cctttgtcta cgagctccca ttcaacaagg cgtccccatt ccccttcact ccggagcccc 49620 ctggaggcag gggagcgcca tgacttagac gcactccagg ccgctccttg gtttcctctc 49680 tgcaggactg cccaagaagt tcgtggacat ctttcagcag actcctctgg gcaggtttct 49740 tgcccagctc catggagagc cgcagcagga acttcttcag tgttacttga aggatttcat 49800 tctcttgacc atgcgtgtgt caacggagga ggaattaaag gtagatgttt agatactggc 49860 taagggtcag gtgtagagct tgcatgatgg ggactggatg cagacacgga gacgtttcct 49920 cagctgcctg gagctggtgc tgtgaagtct gggaacagaa catggtcagc gaagggtgcc 49980 ggtgggtgaa ggggtcgccc agtctcctct caatattcag tgctacaccc tcagtccacc 50040 gcccaggggc tcctaaaaca cggagctttc tgtgaacatg agaagacctc caatttcctt 50100 gacatagctt ctttttaaat gttgagtttc tcttgaaaaa aattaaatac gtaactaacc 50160 ctacagggta agaataaaca agtgaaattc aatagaaagt catacttttg actacctaaa 50220 aattttaaac ttcagtacat aaaaaaggag agtgacaaat ttaagaacat ccttacagct 50280 aatatgacta gaggttaata ttcttaggaa tcaataagaa aataccctaa gttttaaaaa 50340 atgggtaaac gttataaaac aacaatttta taatctcatt aagcatatca acatccagga 50400 aacatttgaa aaattgctta gccttactat taatagcaaa tcaacacaac agtttttaga 50460 tatcatgttt acgtattcat tttgcaaagc tgatttttaa aaacaacagc cgccggccag 50520 tgctgcaaag aaatagccag gccacgcggc tgacagtgta gcgtgcacag tgggcgccct 50580 gcagggctgc gtggcagaac agttgagcac cttatccgat ctgaactgct gactctgtcc 50640 tgaggaaact actggagatg tggacaaata tttggttcac agggatgtcc ttttcagctt 50700 tgcttcgaaa aataagaaat agtttaattg tccggaaata caggatgggc aaattaaagt 50760 atggccgtat gatgggttat tgagcagcca ttaaaaccat gtttttcaag tatactcagt 50820 catagggaaa gttcatgatg tcatgttcag tggcaaaaag cccagacgac acggtgacct 50880 taacgtggga ggagaggcag atagaaaact ggacagaagc aaacgggaca gaatagcaca 50940 catggtttct aatttcctct tttatggttt tccaatagtt cggatttccc acggggaaaa 51000 cataccattt ttgtaattta aaaatatatt ctaaaagctt ttttgaatcc cagtttctgc 51060 agatggctct gtggtcctgc actaggaaac tgaaagcggc gtcagaagcg cccgaggaag 51120 aggtttcctt accgtgggtg caccttgcct accagcgttt cagaagccgt ctgcagaact 51180 tttccagaat cctgaccatc taccctcagg ttctccacag cctgatggaa gcccgttgga 51240 accatgagct ggctggatgt gagatggtat ggccctcctc cgcctgccct gagcaagcct 51300 tgtggtgctt ccaactccac tctgggaatg gagagcttct ggggctgtgt tccaagtggg 51360 agatttcttc acaaggcaca taccttagct gaattcagag atgttaagga cacatctcgc 51420 tgacgcttct cacatcctag acaatgaaag tttaggtcgc aagcctggga cacaagtata 51480 catgcagcta acagccgggg cctctggtgg gccggtggga ggggcaccgc tcagccacgc 51540 cctgctgtcc gtctccccag accctggacg catttgccgc aatggcctgc acggagatgc 51600 tgacaagaaa caccctgaag cccagtcccc aggcgtggct acagttggtg aagaatcttt 51660 ccatgccgct ggagctcatc tgctccgatg agcacatgca aggcagcggg agcctggccc 51720 aggctgtcat cagggaagtc aggtgagacc caggagccct cacccactgc ttcatctggc 51780 gcgcgctcac caggagcctg ccaagtgcca ggcatgtcca tgagaagacg ggcaggtgct 51840 cctgccatgg gaggggctcc gtcctcaccc gttcactccg catttgccga acccttagtg 51900 agtgccaggc gtctcattag ggtgctggag acacgagagg cggctgtgca ttcagggagc 51960 gcactgtgta ctggggccgt agaaaggcag acgggctatt gtgatgccgt gtgagaaatg 52020 ctgtggtaga aaggacaccc cgggcgggca ggtgcacaga gcaggacagg ccctcagggc 52080 cagagtccac ttccctaaag gtgaggtggg acttgacagg cgcaggatca tgcagtgagc 52140 gggttgtggt ggtaccccat gcagaggcat cacagtggga caccgagtcc cagctaagct 52200 gagcgtctga gagcgagagc tgggggcggg ccaggaagta tgtcacatag ggcttgcttg 52260 taatcccagc cgctgggcct ggaccccggg tcccgcatct cttctcccgt ctccctcctc 52320 gtttcaccct tgggttcctt ggtgggagcc gagtgagtga gtgagtggcg ccctcttttg 52380 acagagccca gtggagtcgg attttctcca ccgcactctt cgtggagcac gtgctcctag 52440 gaaccgagag ccgcgtcccc gagttacagg ggctggtgac cgagcacgtc ttcttactag 52500 acaaggtgag tacttgggct ggcctcagca catgcacgga tccacccttt tccgaaagga 52560 agaacagcac tgacagtgat ctgcggctgg gagacgctct tttggctctg accgttttgt 52620 ctagacatgc aaaggaaggt gatttcatca ctaggccatt acattttcca tgtttaattg 52680 tttaattatt taccctctgc tgattgctaa gtcagagcat atcatttaga agtgattcca 52740 ggaactgtgt gcagaaaggg gctgacgcag ggaacatgct tgtgaaacct tcggcaggga 52800 ttacctggcc tttggagtga ccccagaaca gaccactagc ctggccatct gtggaagctg 52860 ttaccatttt catagtcatg gagacaagga tgtcagagaa tgccaccggg gtttggggtc 52920 ttcaaaacag tgctgtcaac agaaccaagg aacaggaagc caccatgcct gtcactcaac 52980 acccttcata aagctactaa tgtggggtgg tctgcagaaa gaaacctgtg accctacagt 53040 gatgcccctc tgtggccacg cagtggtgtc cagcaacagt ggccactcag ccaaacacag 53100 cctcagcctc tgcctcaccc gcacccgtga ccttcacgtg agcacatcca gagccctcac 53160 cgccaggggg tctggaagag gcagcgctgg ctgtccgacc tttggagcac aggaaggttt 53220 actaaaagga ggccagcatg gatgctggat gtgttgactc tgacctatca aaacatcagc 53280 ggcttagaca cagtatcagc tgatttccca cccaggatgg gtatgagcag cccaaggcta 53340 aggtaccagc tccccggagg ctggcacgga gtcaggtgcc cacgctccgt cttgtccctt 53400 cattgtccct aatgttcagc ttccaccccg tggcctggcg tcacagcctg tgggacagaa 53460 agcaggggag gtagaggaca ggccgttttc cttaagagcc caatcccgga cacgcacacg 53520 ccacaccagc tcgtgtctcg tggtcctaaa cttaggcact cggccttatc tggttgcaag 53580 aaactgagga gtttttcgtg gcatggtcat gttccaggtg gaacttgagt tcttctgctg 53640 aaggaaaagg cggagagagg atagtaggac acagccggtg ccccccttcc acccttttcc 53700 ccacacccac acagcatgca gcctctccaa gtctcatcat gtctcggcgc tctgggagat 53760 gcacagggct ttcagccagg tccagcgtgg gtcataaggg ccaggtgccc ataaacccaa 53820 aggtaaagga gctggcccct gcctgctcac atgcccacag gatttgggag gttaggaacg 53880 tggggagggt tttttttggc gataaaatgg cctcagaaac ttactgggtt tctggtttat 53940 ttccttccag tcagatctct gtgcaggtaa ccacagccaa agaccttacc tcgttagttt 54000 tcctgctgga agcctgactt gtacccctac ccagcccccg ctgaagagca gcccttggga 54060 ccatttgaaa caagaggctt gggggaaagc cctgccttcc gccgtgaggc tggctccctc 54120 ggccgggcag gaagttgtcg acggaactgc tgcaggatgg cacgggtggg actgcgggca 54180 tggctggctt ttagttgttt tggatatgta ccttgaaggg gaattcctgg atcatttgat 54240 aactctgttt aactttatgc agaggcactg tattgttttc cacgggggct gcagcatctt 54300 tcttacatcc ccaccagcca ggcaccaggg tctgaatttc tccacatcat gggcaacacc 54360 tgttactatc tgattttttt cataatggcc accgtgataa ttcattgtgg tttttatttg 54420 catttctcta atgactagtt atgatgagca tccttcatgt gcttgttggg catttgctgt 54480 cttctctgga gaaatgtcca ttcaagtcct ttgcccattt ttgaattggg ttgttgatta 54540 acaaagttat taggatatta aaaatacaca catcacttcc aagtaagatt aatcccagca 54600 attcaaggat ggctcaaaat aaaaaaaaaa aaatctgtaa atgtcatcag ttatataaat 54660 taaaagataa actctatatg atcatttcaa aatgtagaga gaaagcattt gataaaatta 54720 tttggaaaga aatacccttg tcaaacttgg aacaggaagg aactctcctt gagctcacaa 54780 tgcccaaggt agacataata ttaagatgtc tataccaaca tcatgcctgc ccatcaaatt 54840 ccattagtac agccattaaa ctatcttgta cagtgatgat gtgtattgcc taaaaaccag 54900 tgtttccact tctaactata tcctagagaa acttctcatt tgctctcaga catatgcaag 54960 aatgttgaat acaggactgt caggaattgc aaaaaaccta aatgcccatt aaccagcaga 55020 caggtaactg gtgtctttat cagtgggtac aggagtgatc tggacctaag gtatcatgaa 55080 gagaatgagt tgcagaagcc tttatacaac gtggtatcat tgatatcaag ttttaaaaca 55140 ttcaaaataa taactccatg ttcagatatg cttacagcta tcctaaaagc agacatttag 55200 aaatatagtt atctctgggg agggacggag ggatgtgaag ttgtaactat atgcataatg 55260 ttttgtttct ctaaaaaatg atctatcgca gcagcttggg aggctgaaag aaaattttaa 55320 aaaatttaaa aattttaaaa aatgatctaa agcaaatatt ccataaatgc tgagatttct 55380 taaagcttgg tggggggtat acagatggtc attattatta cttaaagttt gaaatatctt 55440 agtgagagcg gaggagacct taaaagaaaa agaagaggga aaatcgtaac ttgagaatgt 55500 agtcccctga caagcagcat aatcacaaaa cgagcattca gagttcaagc gttaaacaca 55560 ggatcacaaa ggcctcgcac cccacacccc acacacacgg cgcagccttg gccctgaatg 55620 tggtgctccc tctgtcgccc ggcctggccg ccctcagccc tcccccctgc taatgactcc 55680 tgtccctgcc tttcttcagt gtcttcgaga gaactctgac gtgaagacgc acgggccttt 55740 tgaggccgtg atgcgcactc tctgtgaatg caaggagaca gccagcaaga ccctcagcag 55800 gtgagacctt aggtttggat ctgtgaaggc gagaattctg aacctctcgt ggttttcact 55860 tcttctggcc agtttctctg cttcagaact gattgccctt cttggattct aggtttggga 55920 ttcagccgtg ctccatctgc ctgggagatg caaaggaccc cgtctgtctg ccctgcgacc 55980 acgtgcactg cctgcgctgc ctcagggcct ggtttgcctc agagcagatg atatgcccct 56040 actgtttaac tgccttgcca gacgaattct ctccagctgt ttcccaagcg cacaggtaca 56100 acaccctttc tctcaagaaa gcatcctttt tttcattttc cttttttggc aaacacaata 56160 ttcagaaata taaactctat taaccttcat ttggtagaaa acctgacctc agagaactat 56220 cataagagac gccacttacg tactttcata aatatctggt atctcaagat tattctctcc 56280 ccaagacata cacatacaga tttcagacaa caaattcaga ggaactaagc cagaaagtct 56340 taacaaaggt cctcaccaga ggcccaagga atgtagacgc cagtgttttt tttttttttt 56400 ttgagacagt gtttcactct gttgcccagg ctggagtaca gtggcacgat ctcagctcac 56460 tgcaaccttc acctcctggg ttcaggcaat tctcctgcct cagcctccca agtagctggg 56520 attacaggca tgcaccacca tgcccggcta atttttgtat ttttagtaga gacagggttt 56580 caccatgttg gccaggctgg tctcgaactc ctgacctcag gtgatccacc cgccttggcc 56640 tcccaaagtg cagggattac aggcatgagt gaccacacct ggccgacgcc actggtttta 56700 atgcatcagt atcattcaca gtcactgacc tgaggatcaa cccacttctt gtctagcttt 56760 ttggagctgg ttaaaagcag ctctggctct ctggactcag caggcctcag cccggctctg 56820 tgagtggttg gttttctttc cttccccttc cccccttctc aggcctccta aaagtggggc 56880 accaggcaag cccagtggat gggttctttg acatactttg ggatattgaa gggtattgtt 56940 gccgggtcca aatgatcaaa gtgtttccag aaagggatgc atgtaaatat catctgctga 57000 ggttttgaag actagctcta acgggtgaga ggagtgactt gaatctttca atttaaaagt 57060 aaaatgccag ccaggcatgg tggctcacgc ctgtaatccc agcactctgg gaggccgagg 57120 tgtgtggatc acctgaggtc agcagttcga aaccagcctg gccaacacgg tgaaacccca 57180 tctctactaa aaatacaaaa ttagccaggc gtgatggtgc gtgcctgtaa tcccagctac 57240 ttgggaggct gaggcaggag gatcacttga acctgggagg tggaggttgc agtgagcgga 57300 gatcgcgcca ctgtactcca gcctgggcaa caagagtgaa actccgtctc aaaaaaaaaa 57360 aaaaaagtga aatgctgtgc aaatctcaag tcattctgta aggaggcatt tgggaaacac 57420 catccacctg tcttctgttt ctcgtgttct aagggaagcc attgaaaagc atgcccgctt 57480 ccggcagatg tgcaacagtt tcttcgtaga cctggtgtcc accatttgct tcaaggacaa 57540 cgctccgcct gagaaggaag tgattgagag cctgctctct ctcctcttcg tccaaaaggg 57600 gcgcttaaga gatgctgccc agagtaggtt gctttcttcc tgtaaaccta gcccctcatt 57660 tcttcatctc gcttctgcat gtctcatgca gtgagctgcc tttttctttc tggtttaagg 57720 acactgtgaa cacacaaaat ctctctctcc attcaatgat gttgtggata agactcctgt 57780 catccgctca gtgatactga aactgctttt gaagtacagg taagaacaac atggagactt 57840 gcttctggaa agccctggct ttttctcttc atcgcagcgt tttgttacca agtcttcttg 57900 tcgtgactag tagctagtac atgatcttgg ggagcttttt cggtgagaca cagcctggtt 57960 acttgtactg gttgtgtatt ctgacatttt cacatatagg cacatgagtt tagtattccc 58020 acaagcacac gcatctagca agaagccaac agtgccgtga agggaccaca gtggcgtgag 58080 ggacatggaa ctcaagaggc cagaatctgt ggtgctgagc ctggttccac agcagcgcaa 58140 ctttctgatt tttcagatgg tagcttagaa tcctgctcac cctgaatgtc ctagatgtct 58200 cctaagtttc tattcccctg aacatgggct ctatttcctt ggaaaggatg ttgacatcca 58260 agaatagtat cacctgtggt acttgtatgg atctaatatt gcagttctca aagtgttggt 58320 atggaccctt gggtgtgagg taggtctctg aggttaaaac tattttaaaa attagattac 58380 taagataaat ttgccctttt ttaaaaaaca tgttgatact tatgatgatg ttacaaaaag 58440 cggtgatgag ttaaactgct ggcccctcac gtgaagacac agtagctgga ggtattgttt 58500 tcttcaccgc catgcacacg tggttttctt catgccagtt tcattttagt tttactaaat 58560 cttgactctt gaggatttga cttttcaacg ttttgtggaa atgggaagca cacacaaaac 58620 actcccacta cacaccggag tagacagttg cctcacagaa aatcactcat gacaagccct 58680 gggttatcag ccggctgctg tgttcatgga ccgccacccg tgctgggagg aaggatgcac 58740 atgatacagg tgtccagggc tgggcaggcc tctcctggaa atcagcaaag tgagccagcc 58800 tcagccaaac aactgacaat gttggttggt gatgataaca ttcaagcttt taagctgaaa 58860 ttaaaatttt gaaaagctta tattctccac tatgagcttg tgagcttttg aatacttaaa 58920 gacattttgg ggcaatttgt ggtgatatta atgaatatgg attttttttt ttaaaacgta 58980 gaatacaaat gtgtcaacct ttacaagacc tgcacagccc agtgaaccaa tattttccaa 59040 atgaccaatg cctgatgtca tgaaatcatg tgggtcaaaa aagaaaaaaa tctatttaaa 59100 gtatgggcag acctttttga ttttaacata attgactgaa aaatgcactg atacagtttc 59160 aggctccaca ttgcaactaa cctctagaca tgaccattta tcactgtggg cacagcatta 59220 aggaataata gccacaatca gctgcaaaaa ctattaaaat gttcctcgct attccgagta 59280 tatgaggaca gattttcttc atgttctccc atatgctgca gcgatgggga gcagggcagg 59340 caggccgctg acttccagga gccaggcccc agggccagca caggaatgga agaccaaacc 59400 actcttctca cggattcatg ttttggaaaa tattttaaat gttatttaac atgtaatagc 59460 tttattgtta ttttaaatga atgtatattt ttgaaacctt ttgtttttaa tgtctcataa 59520 ttcctaatat cataaatatt gataatataa cccacataaa agctcttcgg ggttctcaat 59580 ttttaagact ataaaggggt cctgaaacca aagtttgagg acagctggtc taaaatgtga 59640 gttttatatt cctccagtat tatgctaaaa ggttttccat aaaatcttag aaaccacgta 59700 tatgtatgta tatgtttata cacacacaca cacaggacag acgaccgata gatagatgct 59760 ctttttttta gtaaggtatg tctccagatc tgagagaacc aggaataata tttctctttc 59820 tgcagctttc atgatgtaaa agattatatt caggaatatt tgaccctgtt aaaaaagaaa 59880 gcattcataa ctgaagataa aactgaactg tacatgctct tcatcaactg cctggaggta 59940 agtgaactct ctcttccctg aatttctttt ggaaactatc tgaaccacat ggtttaaaat 60000 ttacagaata taattttagt cagtataatt aacgaatgct ctgttccgtg cagaaaagaa 60060 gaaaggtttc aaagacgcgg cttctgcctt cagcaacgta tattttggca tttacttgca 60120 tatacataca aaacagaaca gcctaggaga atatactgcc aaagttaaca gtggttatca 60180 ttgagtgggg acattatgga tactttttat cttcatattt ttatatccaa aatttttata 60240 atgtaaataa attagataat tttttttcct cataggttca cttttcccct ccttcttgtc 60300 cttaaaataa aaaggaatgt taggtttcca taagtcaaga aatttacact gaaacctaca 60360 gtaacattct tctatccttc cttctccaca gtcacattgg cgactgtaga agcttggggc 60420 atccatgttt aaaaaaataa tatccttttc tttcttgttc cttgttcctc aggattcaat 60480 acttgagaag accagtgctt actccagaaa tgatgaactg aaccacctag aagaggaagg 60540 tcgtttcctt aaggcatatt ctccagcaag ccggggccga gagcctgcca acgaggcctc 60600 ggttgaatac ctgcaagagg tggcccggat ccgcctctgc ctcgacagag ctgcagattt 60660 cctctcggag cctgagggag gcccaggcaa gtcttctctg ccttgctttc ctttgggttt 60720 aaagactccg ttatttagaa attcaggaag tatgggaaac tagttcttcg aatagactac 60780 tactgggctt ttctacatcc cctctcccct ggatgtgttt ctgtgaatgc ctgtgggtag 60840 gtccgatgcc ctctggttgg ccttgtgtcc tacaataaat gccctaagtc accagccact 60900 cacccgcttt ctcgttggcc tctcagagat ggccaaggag aagcagtgct acctgcagca 60960 agtcaagcag ttctgtatcc gggtggagaa cgactggcac cgggtgtacc tggtgcggaa 61020 gctcagcagc cagcggggga tggagttcgt gcagggcctc tccaagcccg gccgcccgca 61080 ccagtgggtg tttcccaagg acgttgtcaa gcagcaggtg agaagcgggg ccgggcagca 61140 cacaaacatg cacccccaca gccccataca ccccaaaccc acacaccccc ctaccctcac 61200 accctacccc ccccacaccc caccccctca caccttcccc accacatacc ctcatacccc 61260 cacacctcac cctcacaccc ccacacctca ccctcacacc cagggatggt gccactgctt 61320 ccgcgttccg cctgccctta gcatccccag agccaggaag gaaacctgcc gcttgtctgt 61380 ctggtccttt gtctctgtgc ttcagctgat ttgccccagc ttgtgatcat gtttacactg 61440 cctgctgtag ggccaaggtg agggcactca cctcagagct tctttaatta ggcatcactt 61500 ctaattgaat ttcactcaag gaaagtagaa cattcttgtg gcctttgctt tcagcgaatt 61560 aaacgtagtt cagcttgcaa ggtgcgacct ttttacctct ggcaggcaga gacaggcaag 61620 agcaagaact aggaatagaa gaattgcaga agaggcttca aggccaggct gggcacagtg 61680 gctctcacct gtaattccag cactttggga ggccgaggca ggcggatcac ttgtggtcag 61740 gagtttgtca agaccagcct ggccaacatg gtgaaacctt gtctctactt caaagaaaaa 61800 aaaaattagc tggacatgat ggtgggtgct tgtaatccca gctagtcggg aggctgaggc 61860 aggagaatca cttgaacccg ggaggcagag gttgcagtga gccgagattg caccactgca 61920 ctccagcgcc tgggcgatag agcgagactc cgtctcaaaa aaaaaaaaaa aaaaaagagg 61980 cttcaaggcc tctcagtggt cctttccaga tacccagaaa ttaacaaatt cttattgtcc 62040 aggggataca aaaatggtac taagaacccc ggcactgttt gactaccacc tggggtttag 62100 agttgacatg acttgagcca cccggcctca ggtgtggtgc ggtgcgccgc aaacggagga 62160 agcaagcacc tccccaggta gcgctgccgt cggcaggcat tccctgcact tgcacctctt 62220 cgtctactga ggaggaagct ccctgcgaag agggcaccag actgtcctgc ctcaggccag 62280 gtcagggaat cccagcttgg ctgcctttaa acctcgaatg atcaaccacc tggttcctgt 62340 acccgttcag acggttcttt gcaagacatt cctcccattg ttcaccccca actaacctct 62400 gtattccagg ggctgcggca ggaccaccca ggccagatgg ataggtacct ggtgtacggc 62460 gatgaataca aggctctccg tgatgctgtg gccaaagctg tcctcgagtg caagccactg 62520 ggcattaaga ctgctctgaa ggtaggatgg gcccgtggct tctctctgat accaggtggc 62580 atcccttgga gcctgcatgt tccctggttt atgtcaaatg atgcagggtg atggaccact 62640 gatgcagccc atcacgtgac actgtattgg aagtcacgtg cccacagcct ccagggcgca 62700 cctggctagt gtgcgtgaac cagtggctgg aacaggacag ctatgacagt tgagctgggt 62760 tgacagattt gctgtgtctt gctgatctgc caagtccatc agcagcgcct tttgatttat 62820 gcccattact tcctttgaga ccctgctgga aaacagtcta agaaagatgc tgacacaact 62880 attaatagca aaattcatac ctagatgtat tcataattca gatatgcatg tgtgtttaat 62940 aaaaatacat atgttggtgt agtgtgggaa gttaaaaaat ataaagatgt ttttagaatc 63000 taacctttaa attggtctgg tcttgcttcc tttttgagtc cctgtgccag gaaaagagga 63060 aatggaaaat cctctttctg ctcagaagtt tctaagacca gtgaaggagt cagaagaaca 63120 gatggtgatt ccgttgcttc tgtcattaag ctggctgcta aatatgcgtt gagtttaatc 63180 tgagagtatt tcaggaactt tgtagcccaa aagttgctcg ccagaagact gcccatgtgg 63240 ggcatgaccc caggtgtcca ggcctggaaa aggctccttc ccttttggtg ggttgagggc 63300 tgaggcatgt gaaaagtttc ttttcacatg caaacttcgt gggcctctgg cccttaggta 63360 gatctggcag gcagcggtgc gggggcgtct atcctataat cctagcactt tgggaggccg 63420 aggcatgcag atcacaaggt caggagtttg agaccagcct ggcaaacatg gtgaaacccc 63480 gtgtctacta aaagaaaaaa aaaaagaatt agccggacat ggttgcgtgt gcctgtagtc 63540 ccagctactc gggaggctga gttagaatcg cttgaacccg agaggcagag gttgcagtga 63600 gccgagatca tgccactgca ctccagcctg ggtgacagag caagactcca tctcaaaaaa 63660 aaaagatgtg ttgagctttt aaattcttac ttgataccct tgattttgca ggcctgcaag 63720 accccccaaa gccagcagtc agcctacttc ctgttaacac tgtttagaga ggtggctatt 63780 ttgtacagat cccacaatgc aagcctccac cccacgccag aggtgagtaa ccgcctgcag 63840 ggctgtgttc aaagtctcag tatttggagg gattttattg aatagaatga aagttatcaa 63900 cacaaatcat accataattt ttttatctag gatagaggtt ctcaaccttg ttatgtggag 63960 gaacacataa ccaagctgtt taacccaaag cttgtagaat tataatgaaa actaaagcca 64020 agaacataag ataatgttta acagaataga atatcaaaat taatgcttac gtatgtggat 64080 gctgtgtttg tatatgcaca attctcttct ctgaaaaatt tccccctcaa atggtggtga 64140 tttctccata tttaccttga tatttgatgt gtatttggtg tcagtgtatg tctaagagca 64200 attcacacaa tattctttga tacatcttaa tgttaagttt ttttcctgtc agcaatgtga 64260 agctgtgagc aaattcattg gcgaatgcaa gatcctttca cctcctgata tcagccgttt 64320 tgcaacatcg ctcgtggaca attctgtgcc attgttgagg gcggggccta gtgacagcaa 64380 ccttgatgga acggtgacag aaatggccat tcatgctgca gccgtccttc tgtgtggaca 64440 gaatgaactc ttggagcccc taaagaatct ggccttctcc ccagccacca tggcggtaag 64500 agtaggccac aattccatcg gccttcactg gaacaccccc cagagcttgt cactgtagag 64560 accgagctgc agctgtggga actcttgagc atctttatct cctcagttct ctgcctttgt 64620 gtcacctgat tcttgagcac acaagatagt gacagacttg ccttgccctt tgttatttca 64680 caggaagctg ttctgttttc ttcacagaca gcttgagaag tccagcagaa ggaaagcaga 64740 gttccctttc ttcctctagg cctcctgctg agcagcagca cccaggtgac aagctcactt 64800 atctagagct gtctctgtct tcttgttttt cagcatgctt ttcttccaac catgcctgaa 64860 gacttgctgg ctcaagctcg gaggtggaag ggtctggagc gagtccactg gtacagtaag 64920 tgttggggtc tagatgaccc cacactcctt tgagcttcaa agggtgtcca gatgctatga 64980 agcattgggt tcgacttggg gtccacgtgg tttgtgcctc agggtccaaa accacctgca 65040 ttctaccggt ggcgtctgca gaagacgaat ggcttgaagg agctggcact ccgccggcta 65100 gatgatccaa accatttcat ttctttgtcg tgtggaaaag gccctctgtg atgcacttct 65160 gttctctgga atatgccatt ttgggagaag ggagggactg ggaaccacat cagagacgca 65220 ttcaaaggcc caccacaaaa caaagttttt gacacaaagc tcttctgaaa tatatgaaat 65280 atagaaccgg gagactgact catataaccc atgacatgta aattttgctg ttgcctgagt 65340 aaatatttta aaactagttt ttaaagttgt tataaaatat gctcatgaca aaaaaaaaaa 65400 aatcaaggaa aatagaaagg tctagaatcc tgtccacctt gcctccaaaa gtacccctgg 65460 tatgggccta tattctaatt gctctttact tgataaaatt aataaaatta gactcagaca 65520 tttttcactg acaacataca tttattaagc ttcaggcagg tgtcatgtaa cttaacaaat 65580 tagcgtggga tgctctggac agtcattctc atattgtggt cagggccaga gagtagagag 65640 ttagctttcc cttttcaatg tgggtcattg ggtgaaacct cattagccaa tgtgtgtcct 65700 gttctcttca cagcttgtcc caacggccat ccttgctccg tgggagaggt gagtcttggt 65760 atttaagata gggtttgagg ggtggcgtgc actcctgggt tggaggaggg ggatcgtggg 65820 tcaggagagt gaggctctcg gccttccagg agagcacagg ctcaccgagg actgcccagg 65880 gtgctctgag cagggcaatg ccaatggcgc taagggtttc tagcccaggg cttctcagac 65940 tcagcactgt ggacgtggct ctgcggcgtg ggctgtcctg tgcactgcag gctgtctggc 66000 agtatgcctg acctcgagtc cctggatgcc aggagcaccc actcctccca gtgtgacagc 66060 taaaaccaga cattgacaaa ggtcccctag gaaagaaaat tgctactggt tgggaactgc 66120 tgctagccat tctttctagc cactgcagca tggggtcagt gagccttgtc ttgatagaat 66180 ggcaaggtgt tgcctggacc acaggctgca ttattagccc tcagaggagg tgtggtccag 66240 atgccaaagg aaaaagccac gtgtaggctg tgcgccatgg gggaagaact gttgattatt 66300 cctctctgga ttcccaagca tctagcctag agccctccat acacagtatc tgtacttgct 66360 gagcaagagg ctggtgggtt gagctgacac gtggtagtta gttattagta ttacttactt 66420 ggttgagata tgtctggctc tcttacccag gctggagtgc agagtgacat gatcatagct 66480 cactataaac attgaactcc tgggctcaag cgatcctccc gcctcggcct cccaaagtgt 66540 tgggattatg agccactgtg cccagcctga tacacgtcat ttaataatgt atataagaga 66600 tacggaggga gaaaaactgt tacatacact tcatttttct gagcttcaat cacttccttg 66660 tccatgaaat gaggacgctg aaatagagtc tatccaagaa tgctcccagc tctgaaattc 66720 tgtaactggt ttggtgtgtt atcagccgtg actctcagta tattgtggca caatatctga 66780 ttttgaaaaa taagcctttg gaagtagatt atgtgattag atttttttaa ataaaaaagt 66840 ccaagccagg tgtggtaggt cacacctgta atcccagcac ttcaggaggc tgaggcaggt 66900 ggattgctag atcccaggag tttgagactg gcccgggcaa catgttgaaa ccccgtctct 66960 acaaaaaaac acaaagcatc agcagggcat ggtggtgcat gcgtgcatgc gtgcatgcgt 67020 gtggtcccag ctacttggga ggctaaggta ggaggattgc ttgagcctgg ggaggtcaag 67080 gctgtagtga gccgtgatgg tgccactgca ctccagcctg gaggacagag cgaggctctg 67140 tctcataaaa attgatatat gaaaaagtcc aaatgaatat aaggaagtca gtttggaagc 67200 tcttctagta ttcttggtat tagatcatga agtgccacag gctagtgtga tagatggagg 67260 gatggaaaaa gtgctgaata caagaaagga aggttgaatt ttatatattt gtctataaag 67320 tgtcactctg ggaataaagc ttaaattgtc tcacttattt aaaaaacagt tccagtttgc 67380 ccacgtgcaa cattagtgag tacctaccct gttcccatgg gttctccacc cacccgaaac 67440 aagcacacac tgggacaatc tgagggtgct cacgtctgcc ggtgataagg aggtgttcat 67500 ttgcatgatg gcatttgtgc ataaaatggt actgctccag aagtggttct agtgccctgt 67560 cttcacccta gtgtggcagg ccgatggaac agagcatctg cattgactgc catgcgccga 67620 ttggaggcat tgaccacaaa cctcgggacg gctttcatct ggtcaagtat gtgggtcagg 67680 attctatttc ctaagtactc aaactttggg gtgttgggct gtttttattc cagctgataa 67740 agtgatactc aagatagtac taattactcc agtacatgtg ggcctgtgtc atattgaata 67800 gcaatgccaa agtcccagca gtcacacagc agggaggcat ctgatctgtt gttggatccc 67860 tgggccctga aatgcaaagc aggctaccct ttaacagctg ttaatatgaa tacaggtgtc 67920 ttccttttgg gccttgggtg caccttctgt agaaatatgc atgacataaa cagatgatct 67980 aattcacgag gacatctatg tctgcaggac caaaacctgg gcatccgtct gtctcagcag 68040 atgccatctc acttgccagc aatcttagct ttctccattt tttatttttt gagaaaaatg 68100 aaggagacag acatagtctt atgaaatacc agacttcaga atccaggtac aaatccgatc 68160 ccacaatccc atgctgagat gaatgtggtt ctaaatgctc ctttcagaga gtgagtggga 68220 cctgcgtggg ggcctcacat tctgactgtt ccctgcagtc acagcttaaa atactttcat 68280 gttatctcca gaaactgtca cagtgtcctc catcctctaa tagttttgcc actgagagca 68340 tcggccacac tgcatctcct ctctgccgga ctttagatcc cggtttttcc tttggggaga 68400 tgagaacaat atggacaccc atgggatgcc gactgtcctc ccaaactcta gctgttctta 68460 gcccaaccgc tcctctcctg acaaagactt cagtggaaaa gacgggtcca ggcctgcgtc 68520 ttaacaccct gcccggggat cagcatcaat accacacagc gcagccacct gacgctgaga 68580 atgcggtcgg gtctggtcca ccggaaaggc gagtctatca tgagagagac tcttaggaac 68640 atggtccagg ctttgtggaa cagcaagtac tcttcacata actctcttct cagccgtaag 68700 cctcactcca agtgctgaga aagtgcagcg tgccaaagcg gccagcctca gcctctgtct 68760 tgtgttctct cgttctttcc agagacaagg cagacagaac gcagaccggc cacgtgctgg 68820 gcaacccgca gcggagagac gtggtgacat gtgaccgagg gctgccccca gtggtcttcc 68880 tccttatccg gctactcact cacttggctc tgcttctggg agcgtcccag agttcccagg 68940 tataacccag tgctgccaaa caatgggctc agttaagaac ctgctttcgc ttcttcccag 69000 ggagtccttt tgtcttgagt cctagctgcc atctatgcgt tttggagata attagtctac 69060 aaagtaatat acaagttata catcttcatg tttccccctg tggcgtatga tggtatgggg 69120 ggaactactc cccagattat acagaatcca cttcaaatta acactctgtg tctctggtcc 69180 acatctggga gtagagaggc tgacatcttc attattttac ctgtgtcttc attgtagcta 69240 gggaagaaag agcacactgc ataaccaaga tggccaacag tacaatctgg atattcttta 69300 tctcactgta acaacagaaa agccagcagc cgttccgctt gctagccttc ctttcacctg 69360 gatcactccg ccgttttcat cttagaaacc gccttccgac tctatgctgg tgctccactc 69420 ccaatggcct ctaccaggct caccatcttc tctacaaacc agatccccgc tgaacactct 69480 gttccgttgc ccccacaggc tctgataaac atcattaagc ctccagtgag ggatccaaaa 69540 ggctttctgc agcagcacat cctgaaggac ctggagcagt tggccaagat gctgggacac 69600 agtgccgacg agaccatcgg cgtggtccac ctcgtcctgc gcaggcttct ccaagagcag 69660 caccagctct ctagcagaag tgaggaaagg ggcaagggct gggcggggat cacacagcac 69720 aacggcagcg caagcaggct cgctgtcttg tgggccaccc cacacacagc cagtctgagc 69780 tctgtctgtg ctgttgctgg aaagaatgag agaacacaca gagagaaaac cgtgtctagg 69840 gaaggcgatg cctggggctg gaaaaaggaa gcactctgct tgcccagagg ctggaaggag 69900 ctgctctgtt ccctccattc acccctgcct ggctaagacc tgcggtattc gggagcgtct 69960 gcacgcaagt gttcagtgtg catatatggg gagtcttcag ttccgaagtc agccccgtag 70020 gtcattcccc taccatgctg ggagcacgtg tcgtccacac agagcgtgcg tgtcaaagga 70080 tcaatcacca tcacagttgt gtgctgattt attaaatgtt tatatgtcca cagttatgtt 70140 aaaaaaaaaa agctataaaa tattgtattc actgagctaa ctttctattt taaaaattta 70200 aatccataca gaaagaaaag gtctgtaaga caacttagta aaatggttat atggttatct 70260 gtgagtggtg gaattaagag tgattttctt ttgctaatct gcaaaaatca caatgaccat 70320 tgtgaggaca atgttaattt aaaataataa caataatagc aagaagaagt cctgccccat 70380 gacaagaaaa tctgctccca cctcaggtac ttctttgcct gaaactggca ttcctattta 70440 ttttccattt tgaacaatct gattttattt taagcctctt attctggtgg gatttcagca 70500 aagtgagcac acccagagtc acactgatga aatgacagaa tcctggaagc aggtggacag 70560 ttcccgcagc actccacatc tgtgtggtct gcctcagggt ttgggtggca gcagctgaga 70620 cggctggcgg tagcctgggc cactcttact attgagctca agttctgttc tttcagtaat 70680 ttttttcaaa atgggtctaa gattacaatt atgtaggata gaggaatttt tagagattga 70740 tgttatcttc aaaaggtcat taagttggtg gtaacaacag gaactacttc aaaatactta 70800 gattaattta gaaagctatt acctcaaaac gagtgttatt tctattaaac acttatttag 70860 ggtttattat acgcagactg ctgtgttctt tgtgccttgg gtaacctaca catttggagt 70920 ttttttgtag ggcttttaaa ttttgacaca gaattgtcaa ctaaagaaat gaggaacaac 70980 tgggaaaagg aaatcgcagc tgtgatttct cctgaactgg aggtaagcag taagtgctga 71040 cagctgggtt gctcctcggt ccagaaagga agggtcccgg cgtctgctga atgctccttg 71100 cctgttgccc ctcgtagcgg tgccagcaag agcctttgac tgagccccag attccaatgc 71160 tccccacctc gagtcactcc atcctcctcc tgtccccaag tgctcttccc tcctacagct 71220 ggtcatgaag tcagtccgag gaattcctgg gaatccagca agtgcaggca gtgtttttct 71280 ctccattact ttttacagca gaatgtaatg tacgaggtag agaaataaac tatcacatat 71340 atacccatta aaaatgaact gacaatcata gattaattat tcatctagca gccagaatgt 71400 tagtaagaga aatataggtt tctgaatctc attctgtttg gggagacata catctataaa 71460 caaacaacac tgaaattaga agatcaaagg gaatacctga ttacatgctc agagcagggg 71520 acaaacgccc taatatgcag acacccactg gtggagttac tgggtgttac aatctgtttg 71580 tagcaatacc tcacttccag aatttttttt ttcattttct ccatccagca tctagataaa 71640 acccttccca ccatgaataa tctcatcagc caagataagc gtatcagctc taaccctgtg 71700 gccaaaataa tatatggtga cccagtgacc ttcctgcccc acctgccccg gaaaagtgtg 71760 gtccattgct ctaagatttg gagctgcagg aaaagaatta cagttgagta cctccagcac 71820 attgtggaac agaaaaatgg caaagaaaga gtgcccatcc tctggcattt cctgcagaag 71880 gtatgtctgg cttactgtgg ctccctccct ctttcggtgc agagttcccc agcaggcctg 71940 aaggccctgg gcttttacgt agtataatca ttcttaacag actattccag tgctttggtt 72000 ttgaatagga tgtagcagaa gactcagggc tagagatctt catacatatc aaactgtatg 72060 attgccagaa gcgtaaagtc acagacgaaa tacacaccca cgttgggatt agcagtgacc 72120 tgtggggaag ctggaggcca ggagaggacc tcccctcatc actcagccag acagaaaagg 72180 atgcagctct ttcccagccg ctctgttcct ctctgtccac aatgctggag catgggcaga 72240 tcaaacaaaa ctcctccctg tgcctaagca tcgaggcgta cgtggaagac gggagtgagt 72300 gggtgtgtgc cggcggtgct ggggtactgg ggagcagtca agtgtactgg ccacatctgt 72360 tggaattgga aatatacttt cctaactttc acccatttgc actttcattt tctacaacac 72420 attgtctaaa catttctctc catggactat tatttgctgt ctagcaagga tgaagacgag 72480 ttggaaactt ctgttggtca gttgaggagt atgagttcac aatgacagga aggacttcct 72540 gtcaatactg tggcctctct ctcagatgca gtttcactac gtcgaagatg cttagatcct 72600 aggtcttcgg aaggacaccc aggaataagg ccagccctcg ctgcctaagc tctgggtctc 72660 ttctttcagc agcttctctc cgtacccagc cagttacatg ggcccaaggg acagatttcc 72720 ttcatcagcc tttgatggac gcggctgatg cgtcagctcc atagaggctg ggctccctct 72780 tcgccgccct ccatttctag cacactgcac tgtctgtaga cttgtgggaa gaacttttcc 72840 cgttttcaag ctccacgctg catcacagga aatgacactg accagattaa gctacaaata 72900 caagtctcgc agccagtctc aaagtctgta accccaataa cattttttag gtaaataaaa 72960 attgttactg ggtggtcttc ccttctccag gaagcagagc tgaggctggt aaagttcctg 73020 cctgagattt tggccttgca aagggatcta gtgaagcagt tccagaacgt ccagcaagtt 73080 gaatacagct ccatcaragg cttcctcagc aagcacagct caggtgtggc tctgctctga 73140 caggaccagg actgtcccgc atttggcggt tcgaaaggat cactgcatag gggaacaggg 73200 tggggcggag gggaggaggc gctgatgggt gctctatagc ctaagccctt accatgcggt 73260 gaagggtgct tgaaccccaa aaacatatta gaagctttcg ccacagctga aaagcacctc 73320 cctctctagc tcctcaaact cggctcactc cttcaaacag cacctcagac atgcttgtga 73380 ctgcacaaag caggaaagat gggctctcgg cagagcatgt aactagggtg gtttggccct 73440 ttcagggggt tgctatcata cggttcttac caagtattct gttcaacaga tgggttgagg 73500 cagctgcttc acaacaggat cacagtcttt ctgtccacat ggaacaaact gaggagatcg 73560 cttgagacga acggttagta tcctgtcccc tgtaccacta agcgttccag gagagcctcg 73620 tctgaaagct cttctcgtca gcctgactcg gcccatccct gtcaacaccc agcactgtgt 73680 ttgtttgttt ttgagatgga gtcttgctct gtcgccaggc tggagtgcag tggcaccatc 73740 tcggctcact gcaacctctg cctcccggat tcaagcaatt ctcctgcctc agcccctagt 73800 agagacaggg tttcaccatg ttgcccaggc tggtctcaaa ctcccaagct caggcaatcc 73860 acccgcctcg gcctcccaaa gtgctaggat tacaagcggg agccactgcg cccagccagc 73920 actgttaacg cttaacttgt gtctcttttg atggtggtgt ctggataagt aaaataatgt 73980 gtcaggaaaa taaaccctca gtactcttca gtccctaaat atggcatcaa aagggagctg 74040 aaagcatttg aaactctatc agcatatgag atggggcaga accgagaccc ggctcccggc 74100 tgtgtgtgga gctgatggct tctgcatccc tcctccccac gcctagattc tgtgaggagt 74160 tggaactcct ctctgcttaa gcataaccct gtcgtttaaa ggtgagatca acctacccaa 74220 agactactgc agcactgact tggatctgga cactgagttt gagatcctct tgccacgccg 74280 acggggcctg ggcctctgtg ctaccgctct cgtcagctac ttgattcgcc tacacaatga 74340 aattgtctac gccgtggaaa aactctccaa ggaaaacaac aggtttgtgc acgagccacc 74400 aggaagtggt gcctgctcag cccagagtcc ctaagcccag tggggcagac acaagcaagc 74460 ttcagcccct tccctaacag acactcactc cttcagccgc ccccaccagt gacccgcccc 74520 atacttgggt agggttttcc actgctccaa ctgtgagaaa tgggagcctg ctccctgcaa 74580 catagagccc taggcccgca tgcctggcct ggacgctgag cgctgtcttt ctgcccctca 74640 gctattccgt ggatgccgcc gaggtcactg aactgcatgt catcagttat gaagtggagc 74700 gggacctgac tccactgatt ctctccaact gccagtacca ggtggaggag ggcagagaga 74760 ccgtgcagga gttcgatctg gagaagattc agcggcagat cgtcagccgc ttcctccagg 74820 gcaagccccg gctgagcctc aaggtagggc tgactcctgc cactgctgct catttggtgt 74880 gtctgttgtg aacaagcagc ccttggtgtg tttctcgaga gagggaagca gcacctcacc 74940 ctgcagtctg gtctgtatct cctccctcac acctgcagct cccgaggcca ccacgccacc 75000 tgtatctccg ggccgcaggg ctctcctgag ccctctcctg cagggccatc tgcacctcag 75060 tcccccaagg aactgttgag gtcttttttt gaaacagggt ctcactctgt caccgaggct 75120 gcagggcagt ggtgccaagc ctccacctct gggctcaagc gatcctctca catcagcttc 75180 ccaaatagct gagatcacaa gtgtgcacca ccatgcccag ctaatttgtg tattttttgg 75240 tagagatggg gcttcaccac gttgcccggc tggtctcgaa ctcttgggat caagggatcc 75300 acccgcctag gcctcccaaa gtgctgggat tataggcgtg agccactgca cccagctgat 75360 tgttgaggtc ttgattctac cagttaatgg caccaccacc cccacagccc ctcttccttc 75420 agcctccatg ggtaacctgc cagcagatgc cattagctgt gccttctgtg tgtcctcacc 75480 tgactgccaa agcccaccct gtagttaaaa gcatcctgta cgttggactg ctagccactc 75540 ctaactggtg cccacctcca ggttcttcag tccacggcct aaaacccaca tctggctctc 75600 ttcatcctgt gccggatgga cctgcctggc ctctcatggc atatgggata aagccgacac 75660 tctgttgtct ggtatgggag gccctgtagc tcggcccagc ccaaccttcc agccctgcct 75720 ccagccactt agcccatttc cctgaactgc atcccgtgac ctcatgcact gaagccacac 75780 agcaggcact ttcccatctc tgttctttga ctggacgcac ttgttccttc cagctgcagt 75840 catatctact gtacttatgt acggtaccac ccgcaactgg gccaggaact gtgagagccc 75900 atggattttt tttttttttt tttttttttg agacggagtc tcgctctgtc acccaggctg 75960 gattgcagtg gcgcaatctc agcttgctgc aagctccacc tcccgggttc actcatgcca 76020 ttctcctgcc gcagcctccc gagtagctgg gactacaggc gcccgccacc atgcccggct 76080 aatttttttg tatttttagt agagacgggg tttcaccatg ttagccagga tggtctcgat 76140 ctcttgactt cgtgatctgc ccgtctctgc ctcccaaagg ctgtttttaa ttcattctca 76200 cagccatttc ctctggcaga gtgactgcct gtgcatggtc tgtgccttta gtggctgaat 76260 gaataaatga atgggatatg cacaaatacc tgttgcccta gcgcctcctg tggcgaagca 76320 ggccacgatg atgtgacaat atcttgtcat gtaattggct gtgaggactc cgctggattc 76380 ccggttgtgt tactatttcc atagatggtg ggttaatgac ggagaggggc gctcttagcc 76440 aagggataca cagggcagcg cggcactacg ctgcagtttt ccggctgcag attctgtttg 76500 tcatctgctg gaaatgtcca cgatggattt aattttaaaa aacttttttc tttcccaatt 76560 tagggaatac ccactctggt gtacagacac gactggaact atgaacatct ctttatggac 76620 atcaagaaca aaatggcaca ggtgatcccg ataaacctga tcctgtgcac ggggctttct 76680 gccttctcag tgtgtttccc tccgtgttag gcctactcca gccttgcccc gggtgtttgc 76740 tgtgagccca cagtttctgc ggcctccctt acagagagca agcaagacag caaatcagca 76800 agttttcttg tagagtaaaa gcagattgac atcttgtggg tttgattctt aggaatgatg 76860 ttgatgcatg gccatgcctg ctgaagcggg aagtccatgg aaccgatttg ttcctgctct 76920 ccgcatgcgg gtactgatag gtagacctgt gtgtctccat ggcctccagg aactgcctgc 76980 acaccgtgcg cccaagtgtc agctgttaga gagttggccc cccgcatgtg gcttgggcag 77040 tgaaggggct cggctctctt accaggtggt gagatgccag aaacccagcc cacagacatc 77100 cctctcctgc ttttcatttc ccaggactcc ctccccagct cggtcattag tgccatcagt 77160 ggacagctgc agtcctacag cgatgcctgt gaagtgctgt ctgtcgtaga agtcactctg 77220 gggtttctga gcacagctgg tggggatcca aacatgcagc tgaatgtgta tactcaagac 77280 atcctgcaaa tgggtgatca gacgattcac gtgttaaagg tgggtctcac accgaaaagg 77340 aaatcagcac agcccctcac cctggtctcc tgcttcccgc gagggatagg agcattcagg 77400 gagtgccact ctaggcgctc ctgaaaagga tggggagaca agaacaactg ctcacccagt 77460 cagtccagca taaacaggac acaccaggga cagtagagac agacacgcgc tagaaatgcc 77520 agcagtctag atagagccca aatgtgactg agtacatgag gcccctgcaa acagcgtgat 77580 gtgagcgggc tgtgaggtgc cgcaggaggg aactggtaga taggacagag atggccttca 77640 caaggaggga gatcacatta gtacagggca gaacgaagag aagaatgcct gtgtggagag 77700 cactcaggct ccctggtgca cgacatgagt gggggtgtga gacctcagcc cccactcagg 77760 aattctattc cttctgcagg ccttaaacag atgccagtta aaacacacca ttgccctctg 77820 gcagttcctg tctgctcata agtctgaaca gctgctgcgg ctgcacaaag taagtctggt 77880 ctcttcctct ctgctggaca gagggactgc gctcccttct ccctgcaggc tttaatgctt 77940 catttgctct tccgtcgttt taggagccat ttggggaaat cagttcaagg tacaaagcgg 78000 atctgagccc ggaaaatgct aagctcctca gcacattcct aaatcagact ggcctagacg 78060 ccttcctgct agagctgcac gaaatgataa tcttgaaact aaagaacccc caaacccaaa 78120 ccgaggagcg cttccgccct cagtggaggt atggatttgc acacctatgg ggcggggcag 78180 acacaatgtt gtgctgtctc tcctgtgatc ttctatagac acaaaaatag ttcttttctt 78240 accacagaat cccatttcct gctttttgtc attaccaggg cacctgagga ctggcttttt 78300 ggttttaatc tctactgggt tttctttaag caattacaca agtgtttttc agacaagagt 78360 cttgccctgt tacccaggct ggagtgcagt ggagtaatct caactcactg caaccttggc 78420 tcactgcaac ctctgcctcc caggttcaag cgagtctcat gcctcagctt cccaaatagc 78480 tgggactaca ggcgtgtacc accatgcctg gctaattttt gtatttttag tagagacaga 78540 gtttcactgt gttggccagg ctggtctcga actcctggcc tgaaatgatc tgcccgcttt 78600 ggcctctcaa agtgctagaa tgaaaaggcg tgagccacta cacccagcct aaaagtcata 78660 tattctaatt ttataacaag tagactatgt caaagagagg tacattttaa atttgataga 78720 aaaagctatc ctaggccggg tgtggaggct taccctgtaa tcccagcact ttgggaggcc 78780 gaggtgggtg gatcacctga ggtcaggagt tcaagaccag cctggccaac tggtgaaact 78840 ctgtttctac taaaaataca aaaattagcc aggcatggtg gtacacacct gcagtcccac 78900 ctactcagga ggctgaggca ggagaattgc tttaacctgg gaggtggaga ttgcagtgag 78960 ctgagatcgc accactgcac tccagcctgg gcaacagagg gagacttcat ctcaaaaaca 79020 aacaaaaaaa agaatagaaa aagctatacc aatgtataaa gagtgtatga gaatactcaa 79080 cattggatat tatccatctt ttacatagtt gccaatctaa aggccaaaat ggtatctcat 79140 tttcagttgt atttccccat ttaccgtgag gctgaacatg ttttttatat ttatcaccca 79200 tttgtatatc atcctctgaa ttgcctttat gttttatttt ttgagaccgt gtctcactcc 79260 cacccaagct ggagtgcagt ggcgcaatct tggcttagtg caaccgctgc cttctgggtt 79320 caatcgattc tcctgcctta gcctccctag tagctgggat tacaggtgcc aaccatcacg 79380 cccagctaat tttttctatt ttagtacaga gacggggttt ctccacgtgg ccaggctggt 79440 ctcgagctcc tgacctcaag tgattcacaa gctttggcca ccacacccag cctaaattac 79500 ctcttcgtat ctttttcttt tgcgctttgt ctctgtaatg gttgtgagag ctctttgcat 79560 agaacagggg ttcatcttct ctgccgtgtg ccacagtgct ctatttcagc ctttaatttt 79620 atgaagtcaa atctgacaga attttcctat aaagggtctc tatacaaaaa cacttactag 79680 gatcttcctt atcccaggat tataaactag cctttttttt tttttttttt tttttttttt 79740 gagatggagt cttgctgtgt catccaggct agagtgcaat ggtgtcatct tagctcactg 79800 caacctctgc ctcctgggtt caagcgattc tcctgcctca gcctcccgag tagctgggac 79860 tacaggcatg cacctgcccg gctaattttt ttgtactttt agtagagacg ggtttcacca 79920 tgttgaccag gctggtctcg atctcctgac ctcaagtgat ctgcccgtct cggcctccca 79980 aagtgctagg attacaggcg tgagccactg cgcccggcct gtcctctctc ttcttgtgct 80040 ttcacatact tgttttattc accagtttat gtttaggtgt aaagtaagga tttaacttga 80100 tgttttcctg actagatcat caaactccag tcttcctcac caatatgttt cctatttgct 80160 atcttcctcc attatgctat gtggcatata ccatatacat ttatgttctt tcaacttttt 80220 caacaagtct ttactagcct gtgcttttca tgtagataaa aaagatccct ttcctagaga 80280 atttccagtc tttgttaatg tgaaacatgt aatagaatac aaggtttttt gaatggtgag 80340 gccttgttta tgcaaccctg taaataaaca tcaccttgct agagggccta aagtcatgtg 80400 aaggggccag cacagggctt gctccgtggg cttctgtcgt gtttgtgtac tgcatgtggg 80460 aagcagcagt caggcaccag agccttgaac ccaggatgct agtcccagtt caggagctca 80520 ggtcattgac cttaaactgc tcctcaggat ttctgggttt tttttttttc tcgctctgtc 80580 gcccaggctg gagtgcagtg gtgcaatctc ggctcactgc aagctccacc tcctgggttc 80640 aagtgatttt cctgcctcag cctcccgagt agctgggatt acaggcaccc accgccatgc 80700 ctggctaatt tttgtatttt tactagagac agggtttctc catgttggct aggctggtct 80760 cgaactcctg acttcaagtg atccacctgc ctcagcctcc caaagtgcta ggattatagg 80820 cgtgagccac tgcgcctggc ctaggatttt aagtcttaac gagcattttg gttctgctga 80880 tgacaacggg aaaaagtaac atgaggggac tgattggtcc ccttatgtta tatgggagcc 80940 tttttttttg agacaggatc tcactgtggc ccaggctgga gtgcagttgt gcaatctcag 81000 ctcgctgtag cctccacctc ctggactcaa gtggtcctcc cacctcagcc tcctgagtag 81060 cttcggacta taggcataca ccaccacgtg cccagctaat ttttgtattt ttgctagaga 81120 cagggtttcg ccatgttgcc caggctggtc ttgaactcct gacctccact gacccaccca 81180 cctcagcctc ccacagtgct gggcttacac acgtgagcca cacagtgctg ggcttacaca 81240 cgtgagccac catgctgagg agactgtttt aaatgctctc ttctttggtt tttcagcctg 81300 agagacactc tcgtaagtta catgcaaact aaagaaagtg aaattcttcc tgaaatggca 81360 tctcagttcc cagaagagat actgctcgcc agctgtgtct cagtgtggaa aacagctgct 81420 gtgctgaaat ggaatcgaga aatgagatag aattatttcc tcagctatct ttggatgact 81480 ttggagagaa gactcctctc tcctcgtctg cggcgtggac ttgatcatgg actggtgcct 81540 ttgcattcag aaggagagct gtcagcgtag caccgaattc aagaccaagg cgtgctacct 81600 gagctgacag ctttttgaaa gccgagctgt ttctgaacca tgtacataca tgttctgaaa 81660 ctttctcatc attttatgag tactgttcat tgagagatga caatgaagat tagatgaaat 81720 tggaaataaa ccaacattgt ttacattcca ggagacttgt agctcagcca cacacgcagt 81780 aatgacctgt gcccgttcgc ctctggcact gcccacccct cttttttttt ttcttctaat 81840 tctgtactca caaaagagaa tctcattttc ttctttcttc cattccctta aattctgagt 81900 actgtacata tatttctggg ttcccacgat gatgtgaaaa actaccagac tgttttttgt 81960 cttctcacaa agacaagaaa aatcagggca ttttgtgagt gccttaagat caaactaaca 82020 agatctgacc ctctcccctc acagtgagcc actgccccac ttcagagggt aagagccaaa 82080 agcctcattg tgaaaggcac tggacttgga ccagggacac catcagggcc ttggttttct 82140 cacgcataaa atggagagtg gattaatcgc caaagattct tctgatctga cattttgaaa 82200 ttgtgagaga aactagatga ctgtaaactt ggtcacaggc ctggttctgg cagttctttg 82260 cggacttttt tctagcatta tgccaaataa acatgcagtc tcagtgtgct ctcgcatgta 82320 tgaatatcta gtcctttctg tggttctcag ccaagacata aaaactagga ctcagagcac 82380 atacaaaacc agttatgttt cggaaagagg gaaaagagtc cccgagcccg gatcttgtgc 82440 tgcttttctc actgacgtgt tgcctttttt ctttacaaaa tctgctttga tacttaggac 82500 ctctctggac taatttctct tcctagacag ctcagcacag ctattgatat gttagaggca 82560 gtatccttaa tattcattct aaatgagtta acgacttaac ttgaaattgg gcctaaggag 82620 tgagaactac aaaaatacaa aatgcttgtc caggactcag ccatgcacac cttgagcagc 82680 gccggcagga ggcacggaag gaactgtgct ccgttctcct cactgtcatg gtgccaccag 82740 tgtctgatga agggcagagt gacccagact gcaggcagta actgacttca cacagtccct 82800 ggcatttagt catctgtgat tgttttatca ctctggactg tgcagagcca cctgccaccg 82860 agatctgcat tccgactgcc tatgaacggg tgtgggggcc gggggctggc ttgctgaagt 82920 cttcaacttg cactcggagc tcctttgata cctcagagct ggctgtcagg tggcagctca 82980 cacccagact cactggccac acctcagcag ggggggagtc gagtgtcagt ctctttctgt 83040 gaaggctttt tttttccttt ggcctgggaa tttttcccat ttttatgaag gggttttaaa 83100 ttgtttcatt ttgtgtgctg tgcttcaaag ccttaactgt caaatcttgc attatcttgt 83160 ttgtacagaa atatactggc ctagcagagg caaaaaaaaa aaaaatgaat tttattttac 83220 ttgtcacacc tgtcttaata aactggagtt ttgctgctaa agaactcttc tctctggggg 83280 cagagcttct atttatggca catagacatc agctaggctt ttgggaatcg tttgtgttct 83340 ttgtggaaat gtcctttaga agcacccatg aagtagtgtg ttcagactgt gcacacagaa 83400 aacaggctct gccttcacat gtgagacggt ggacttttcc tctggacaaa atgacagcat 83460 cctggcgact ccacagtgga gctgagcgcc actccctgta gccgatctgg gactgaaacg 83520 cttacacctc tgcctcagaa ggagtccccc atgccctgcc tgaaatgact tcactggaca 83580 cagcggggct gcagctaacg gggtacaggt aggagctaac taacttcacc cctgagtcca 83640 cttgcggggt aagagataaa cagtaaccct tccaggagcc cactgacgtt ggagtgctaa 83700 aaatgcccct tcagggggaa aactgcattt tctcttccaa aaaggaaagg ttcttccagg 83760 cgagaaacct gtggtctaga accacagcaa gaagaggagg catgctggcc tgcaccggaa 83820 gactcacttt gtctgccctg cgccagcctc acctcaccct gcagttcccg tttccgccat 83880 ggatgcctca tcaccaaccc tgaccttccc cctcccaacc ctttattcat cctcactccc 83940 actcataccc gcctccctgg acagttccct gctgcagagt tctttctgct ttcagcccta 84000 ccttggtggt gatttacctg aaaatcttca caactgatca ttatctcctt ctctttgaga 84060 cctgactgaa aaaattaggt gtgcacacct gtaatcccag ctacctggga ggctgaggta 84120 tgaggattgc ttgagcctgg gagtttgagg ctgcagtgag ctatgattgc accactgcac 84180 tccaacctgg gtgacagagt gagaccctgt ctcaaaaaaa aataaaataa ggaccttatt 84240 gtgtgtgcaa attatttgcc tttcatgaat agttatgaga ctttgtgcat gtgttaaccg 84300 agacggccct gagctatttc agttactcct gtatgttcag gcaattccaa tttagaaaca 84360 aacttccagt gataaatatt gggaagaaaa tgtcagctca gggccaagta ggtaaagcca 84420 cccaagtcta gccatgcaca caggcactag tgtgctgaag gaaaacacct ctgatttgat 84480 acataaagtg tgaaggttgc ataactgggg aggtggctgg agaaaacctg agcctcgagc 84540 tgagtaacaa tccaagccat gattagcatt tatattgcat tctgcattat tctcatccta 84600 tcacgttcat taagttcaac cattaccatt acgaatcccg tttccagctg gaaaaacaag 84660 cgccaggaaa gtgcatttcc cccccacccc ccccccccaa ccagagcaac tttggtcaga 84720 agtcacacct aatcaccctc tctgcaggat atgctgggga tagccctttt gaggaggtgg 84780 gggtgtatgc gaaagcaacc tggggccaaa gcagggggaa gcaggagaga ctggaggggc 84840 cctgggtcca gcaagtgctc caccaggctg cccctgctca ggtgctccac agcccataaa 84900 aaacgccttc agccctgctg tgcttcccct cacacctaaa cttactataa gggtcctacc 84960 ttccccagta ttccttcatg atcactgcta cctgtgccct gaagcgcaac agaacctcaa 85020 cccagaggac agccacttcc tcagaaccca cgatctttgc cccatcgcca caggtccatg 85080 agtgactcct aattaccaaa tccaagggct ccttcaccct gaccactctg gaacccaaca 85140 aagctgacac acagcccagc ccagacaggc ctgaatgtgg gtcctggctc tcccatttgc 85200 cagttctaca gccatgggca agtggctcga cctctctaag cttcagtttc ctcgtctgtg 85260 aaatatctgt cagtgctctt aagggaggag accaccccac atattgtctt acgcccaatt 85320 tctgcctcca aagagagaag taaaaactaa aaggcagaaa tgaaatccac aagcagacag 85380 cctgcaccac accctgggcc tggtagttaa agatcgacgc ctgacctaat cagtgatgct 85440 atctatagat tacagacatt atatagaaaa gcaccgtgaa aatccctgtc ctgttctgtt 85500 ccgttctaat tacgggtgca tgcagccccc agtcacgtac cccctgcttg ctcaatcaat 85560 cacgaccctc tcacgcagac cccttaagag ttgtgagccc ttaaaaggga caggaattgc 85620 tcactcgggg agctcagttg ttggagacat gagtcttgcc gaagcgcccg gctgaataaa 85680 gcccttcttt aactcgtgtc tgaggggttt tctctgcagc ttgtcctgct acatttcttg 85740 gttccctgac caggaatcta ggtgattaat ggatggttga ggcagcccct cagacggctt 85800 aggcctgccc tgtggagcat ccctgtggag gactccagcc agcttgagcg acatggatcc 85860 tgagagcgct ctcaggcagg caattgcccc agtggaatgc ctggccagag cagtgtgtag 85920 caggcccccg aggaggatca acgcagtggc tgaacaccgg gaaggaactg ccacttggag 85980 tccagacatc tgaaacttgg taagactggt ctttggaact tgcccactcc atttgagggg 86040 aagcgtggcc tgatcaccca cggcgtgcct gtactggcac tctggttttt gtttttgact 86100 tgacttggat tgcttgatac tttggttttg gttttgacct gacttggata tcctgatact 86160 ctgattttgg ttttgatttt ggtttggtgt aaactgtaaa agtgtgtgtg tgcccttttt 86220 acctgttctt tgttttgtgg tatgcgtgta gggtgagcgt aatgttttgt cttgaagaag 86280 catgggtcaa gcacaaagta agaccacccc actaggaact atgctgaaaa atttcaggaa 86340 aggatttaag ggagactatg gagtactatg acaccaggaa aacttaaaac tttgtgtaag 86400 atagactggc cagcattaga ggtaggttgg ccatcagagt gaagcctgga caggtccctt 86460 gtttcaaagg tatggcacaa ggtaacctgt aagccagggt acccacacca gttcccgtac 86520 acagacactt ggttacagct ggttttagac tccccacccg cccgccccaa cagtggttga 86580 gagaacagca gcataagtgg ctggcagagg caaggaaaga ccagcagaga gagaaagagg 86640 aagagacaga caaagaggga gtcagagaga gagagagaaa gagacagagg caaaaggaaa 86700 gtcaaagaga aagagacaga aaatcaagag gaaaaaaaga aaaaaagaga tatatataca 86760 agtagttaga aacaacaaca acactgtacc ctattccttt aaaagccaag ataaatttaa 86820 aacctataat tgataattga aagtattctc tgtaaccctg taacactcca ataccacttt 86880 gttgtcagtg taaacaaggg catatcccga aagcactgag gccttcccat caaaaatcct 86940 taacccagta acccgtggat ggctcaaatg cattcaatct gtagctgcaa ctgctttgct 87000 aacagaaaaa agtaaaaaaa taacttttac aggaaacctc attgtgagca cacctcacca 87060 gttcagaagt agcctaagga aaaaaaaaaa aggatgattt aactttaact actgaaaatt 87120 cccttaaccc agcaggtttc ctaacagggg atctaaatct taattaccgt acaaaggccc 87180 taccatacct aggaggaact cccttcagga aaggatgatc tatggttcct cccaggtaat 87240 taaaggaaaa aaaaaaagcc atctatacga attctaagtt aattttgaca aaacgaggtc 87300 ttactaatag caaaggataa ttaaaatccc aagcttacaa ggttttcaac aaaagtaaag 87360 tttgctaaaa gttaacagtg taacatgtat tatagtaatt tctgatcttg tggcctcaga 87420 cagtctagtc cacagacata aaagaagttc gctttggaaa agaatggtta tcatcttcag 87480 gaaaaaaaaa aagaaggggc agaatttaca taaaaagagt gttatatggt aaattcttgt 87540 cctgaaataa attaactggt tgtttaaaga aagaaatgtt tgtaataagt cagaaagttg 87600 aggcatgtcg aagaattgtc tgcgaaagtc gtgaaagaga aaaatgttat aaaaaattat 87660 gcaagaaatg ttgtataatt taaaagtaac taggcctcct aaatgtaaaa ctattgaaag 87720 aaaaaaaaaa cagtttatgt gcaagtgtca ggcctctgag cccaagctaa gccatcatat 87780 ccccagggac ctgcacgtat acatccagat ggcctgaagc aactgaagat ccacaaagga 87840 agtgaaaata gccttaactg atgacattcc accattgtga tttgtttctg ccccatccta 87900 actgatcaat gtactttgta atctctccca cccttaagaa ggttcttcgt aattctttgt 87960 aatcccaccc ttgagaatgt actttgtgag atccaccccc tgcctgcaaa acattgctcc 88020 taactccacc gcctatccca aacctacaag aactaatgat aatcccacca cactttgctg 88080 actctctttt tggactcagc ccgcctgcac ccaggtgaaa taaacagcct tgttgctcac 88140 acaaagcctg tttggtggtc tcttcacacg gatgcgtgtg acgtgcgtga catttggtac 88200 caaagatccg ggacgggagt actccttaca gagaccggtc ccctgtcctc atcctcactc 88260 catgaggaga tccacgtaca acctcgggtt ctcagaccaa ccagcccaag gaacatctca 88320 tgaatttcaa atcgggtaag tggtcttttc actctcttct ccagcctctc tcgctaccct 88380 tcagtctccc tgtccttcca attccagttc tttttcctct ctagtagaga caaaggagac 88440 atattttatc cgtggaccca aaactccggc gccagtcacg gactcggcaa gacagtcttc 88500 ccctggtgtt taatgactgc agggacgcct gcctgattat tcacccacac tccactggtg 88560 tctaatcact gtggggatgc ctgccttggt cattcaccca cattcccttg gtggcaagtc 88620 aattgcgggg acaacctgct ttggctgctc acccacattg cagcccacgg ctgctcccta 88680 ccccccttct ccgtgtctct acccttctct ttaaactggc ctccttcact gtgggcaacc 88740 tttcaccctc cattcctcct tcttctccct tagcctgtgt tctcaagaac ttaaaacctc 88800 ttcaactctc acttgaccta aaatctaagc atcttatttt cttctgcaac accgcttggc 88860 cccagtacga actcgacaat ggttctaaat ggccagaaaa tggcactttt gatttctcca 88920 tcctgcaaga cctagataat ttttgtcgaa aaatgggcaa atagtctgag gtgccttacg 88980 tccaggcatt tttcagactt cgttccctcc ctagtctctg ttcccactgt gactcatccc 89040 aaatcctcct cctttccctc ccgcctgtcc cttcagtccc aacctcgagc gttgctgagt 89100 cttgtgaatc ttccttttct gctgacccat ctgacccctc acctcctccc caggctgctc 89160 ctcctcagct cgctccccgc caggctgatc aggctccagc tcttcttcag cctctgctcc 89220 ccaccctata acccttctat tacctccctc ccacacccgg tccggtttac agtttctttc 89280 tgcgaccagc tctcccccat ctgcccaaca atttcctcat agagaggtgg ctggagctga 89340 aggcatatgt cagggtacat gtgccttttt ctctatcaga cctttcccaa atcagccagc 89400 gtttaggctc tttctcatca gaccccacta aatacataca ggaattccga tatctaactc 89460 tgtcctacag tttaacctgg agtgactgaa atgtcatcct aacttctacc ctctccccag 89520 ataaatggga aagagttttt tctctagccc aatctcacac tgacaaccac cggcttcacg 89580 agccagacct ccaggagggc atcagagcag ttccccgaga agatccccag tggaactacc 89640 aggcagattc cccaggtata gctacgcgag attacatggt ttcctgccta gttgaagggc 89700 ttaaaaaggc agcttacaaa gctgttaatt atgacaaaca agaaactacc cgaggtgaag 89760 atgaaaaccc agcccagttc atggcccact tggcagtaac ccttagacgc tttaccgccc 89820 tagacccaga ggggccagga ggccgcctta ttcttaatat gcattttatc acccagtcag 89880 ctcctgatgt tagaaaaaag attcaaaaac tggaatccag ccctcatacc ccacaacagg 89940 aattaatcaa cctcaccttc aaggtgtaca ataataggag gtagccagac agcaacgcat 90000 ttctgagtta cagctactcg cctctgctgt aagacagccc acaaccacgt ctccagcata 90060 caagaacttc agaacatcca agccacagct cccaggggct ccttcaaaac atcctcgtgg 90120 gccttgcttc aaatgccaaa agcctggcca ctgggccaag gaatgcccgc agcctgggat 90180 tcctcctaag ctgtgccctg tctgtgcgcg cccccactgg aggtcggact gtccgactca 90240 catcgccgct gctcctaaag cacctggagc ccaaacccaa cgttccttgg ccaactcctt 90300 cccagatctc ctcggcttag tggctgaaga ctgacgctgc ccatcgcctc gggagcccct 90360 ggaccatcac agacactttg ggtaactctt acagtggagg ataagtctgt ccctttctta 90420 atcaatacag aggctaccca ctccacatta accttttttt caagggcctg tttcccttgc 90480 ctccgtaact gttgtgggta ttggcggcca ggcttctaaa cctcttaaat tccccaactc 90540 tggtgccaac ttggacaaca ttcttttatg cacccctttt tagttatccc cacctgccca 90600 gatcccttac tagattgaga cattttaact aaattatctg cttccctgac tattcctagc 90660 ctacaaccac acctcattgc cacccttttc tccagttcaa agccgccttc acaccctccc 90720 cttggatctc cccaccttaa tccacaagta taggacacct ctactcccac cttggcaacc 90780 aatcatgcac cccttaccat cccattaaaa cctaatcact cttaccccac tcaatgccaa 90840 tatcccatcc cacagcacac tttaaaagga ttaaagcctg ttatcactcg cctgttatag 90900 catggccttt taaaacccat aaacactcct tataattccc ccattttacc tgttccaaaa 90960 actggacaag ccttacaggt taatttcaga atctgcacct tatcaaccaa attgtcttgc 91020 ctatccaccc tgtggcgcca aagccatata ctcttctatc ctcaatacct ccctccagaa 91080 cccctctaca tatattatta tgtagatatg tacatatcta catatgtaca taatctacat 91140 aacccattct gttctggatc tcaaacatgc tttctttact attcctttgc acccttcatc 91200 ccagcctctc ttcattttca cttggactga cccggacacc catcaggctc agcaaattac 91260 ctgggctgta ctgccacaag gcttcacgga cagccccccc cccccccgtt acttcagtca 91320 agcccaaatt tcttcctcat cctttaccta tctcgactta attcttcatg aaaacacagt 91380 gctctccctg ctgatcgtgt ctagctaatc tcccaaaccc cgaccccttc tacaaagcaa 91440 cagctccttt ccttcctagg catggttaga tactccgcct ttggatacct agctttacca 91500 tcctgactaa accatcatat aaactcacaa aagcaaaccc agctgacccc acagatccta 91560 aatcctttcg ccactcctct ttccgttccc tgaaaacagc cctagaagct gctcccacac 91620 tagctctccc taactcatcc caacactttt tcattacata cagccaaagt gcagggttgt 91680 gcagtcagaa ttcttacaca agagccagga acggcccctg cagcccttct gtccaaacaa 91740 cttgacctta ctgttttagg ctagccccca cattattcct gataccacac ctgacccccc 91800 atgactgtat ctctctaatc cacctagcat ttactcaatt tccccatatt tccttctttc 91860 ctgttcctca ccctgatcac acttggttta ttgatggcag ttccaccagg cctaatcgcc 91920 actcaccagc aaaggcaggc tatgctatag taacttccac acctatcatt gaggctacca 91980 ctctgccccc ctccactacc tctcagcaag ccaaactcat tgccttaact caagccctca 92040 ctcttgcaga aggagtacgt gtcaatattt atactgactc tatgccttcc atagagtcag 92100 catgcaccac catgctgtta tatgggcaga gagaggtttc ctcactatgt aagggtcctc 92160 catcattaat gcctctttaa taaaaattct tctcaaggtc gctttacttc caaaggaatc 92220 tggagtcatt tactgcaaga gccatcaaaa ggcatcagat cccatcattc agggcaacac 92280 ttatgctgat aagttagcta aagaagcagc ttagttttcc aacttctgtc cctcacggcc 92340 agtttttctc cttctcatcg gtcactccta cctactctcc cactgaaact tccacctatc 92400 aatctcttcc cacacaatgt aaatggttct tagacaaagg aaaatatctc cttccagcct 92460 cacaggccca ttctattcta tcatcatttc acaacctctt ccatgtaggt tacaagccgc 92520 tagcctgtct cttagaacct ctcatttcct ttccatcgtg gaaatctatc ctcaaggaaa 92580 tcacttctca gtgttccatc tgctattcta ctactcctca aggattgttc aggccccctc 92640 cctccctaca catcaagcgc ggggatttgc ccctgcccag gaccggcaaa ttgactttac 92700 tcacaggccc cgagtcagga aactaaaata cctcttggtc tggatagatg ctttcactgg 92760 atgcgtagag gcctttccca cagggtctgg gaaggccacc gcagtcattt cttctcttct 92820 gtcagacata attcctcggt ttggccttcc cacctctata cagtctgata acggaccggc 92880 ctttattagt caaatcaccc aagcagtttc tcaggctctt ggtattcagt ggaaccttca 92940 tatcccttac catctcaatc ttcaggaaag gtagaaggga ctaatggtct tttacagaca 93000 cacctcacca agctcagcct ccagcttaaa aaggactgga cagtacttct acctcttgcc 93060 cttctcagaa ttagagcctg tcctcaagaa gctacacggt acagtccatt taaactttta 93120 tgtggacgca ctttcttgct cagccccaac ctcatcccag acaccagccc tctaggcaac 93180 tatcttccag tctttcagca ggctagacag gaaattcgcc aggctgctaa tcttctcttg 93240 cctactccag attcccagcc acatgaagac accctagctg gatggtcagt tcttgttaat 93300 aatctgaccc ctcaaactct acaacctcga tggaccggac cctacttaaa catctatagt 93360 acccccaacc accatctgcc tgcagaaccc tccccactgg gttcaccgtt ccagaataaa 93420 gctgtgtccg tcagacagcc agtccgatat ctcctcttcc tcctggaagt cgcaagtact 93480 ctcccctact tcccttaaac tcactcgcat ttctgaagaa caataaccct tatgagccta 93540 atacatccct tcattctatt aggtctatcc atccttaccc tactcttcgc aacagggctt 93600 tacgcagtca cccccactac ttggactgtg ccccaaaaac ctgtcatccc tactatcttc 93660 tgtctagtca tactcctatt caccattctc aactactcat aaatgacctg ctcttgttta 93720 cactgccagt ttacattgtt tctccaagac atcacagctg atatctcctg gtgatatccc 93780 caaaccgcca ctcttgactc ctgcttggag tggatagatg atctttggtg gcagggcacc 93840 ctccaacact tccaccctga tgaagttcta ttctttactt ttatattcac tcttattctc 93900 attcccattc ttatgccact ctctacctct ccccagttac ctccagcata ctatcaatct 93960 cacccactct ctcctcactg cctccaatcc ttttctagca aagaattgtt ggctacgcgt 94020 ttccctttcc tcctgctttt acacagccat ccctgctcta caggctgact gggctacctc 94080 tcccgtctcc ctgcaactca gaacctcctt taataaccct catctttacc cgcctgagga 94140 acttctttat tttctagaca gatttggtga gaactcccca gacatttcac accaacgagc 94200 tgccacactt ctccgcatct acttacggca tctttctcct tatgtcaatt ccactcctcc 94260 catatttgga ccccaaccac acaaacaact atccctgttg ccgtttcttt atgcatctcc 94320 cgacaacagc ctgctggaat ccctttaggc aaccttccac cgtccaaatg ttcctttact 94380 ctttgtctcc agaacccagc cacacacatt accaaacaga tgggagcatt ccaacttcgc 94440 attactgaca agccctctat cattattgac aaactaaaaa acattggcag tcactattgt 94500 ttaggaagac acctaccctg catctcaccc catccttggc taccaccctc ccctgctcgt 94560 ctgaatctcc tcctagcccc tcctcttgct tgcttatacc ctgccccatg aatagcagcg 94620 aaaggttact tgtagacact atgcgctttc tcatacacca tgaaaaccaa acccctccct 94680 ctacgcagtt gcaccatcaa tccccattac aacctctaac ggctgctgcc cttgctggat 94740 cgctaggatt ctggatgcag gattcctctt tcagtacacc ctctcacctt ttcactttac 94800 atttccagtt ctgcctgaca caaggtctct tctttttatg tggctcttcc acctacatgt 94860 gcctacctgc caaatggatg ggcacatgta ctctagtctt ccttacctcc aaaatccagt 94920 ttgcagatgg gaacgaacaa ctgcctgtcc ccctcatgac atcaacacaa caaaaaagag 94980 tcatcccact aatcccttta cttattggtc taggactttc tgcctccagt attgcacttg 95040 gaactggaat agcaggcatc tcaacctctg tcacaacagt ccgcagcctc tctaatgact 95100 tctctgctag cactacagat agatcacaaa ctttatctgt tctccaagcc caggttaact 95160 ctttagctgc agttgtcctc cagaacggcc aaggccgcga tttactcact gctgaaaaag 95220 gaggactctg tatattttta aatgaagagt gttgttttta cctaaatcaa tctggcctgc 95280 tatatgacaa cataaaaaaa ctcaaggata gagcccaaaa gctcgccaac caagcaaaca 95340 ataacattga acccccttgg acactctcta attggacgtc ctgggtactc ccaattctta 95400 gtcctttaat acctattttt ctccttcttt tattcggacc ttgtgtcttt cgtttagttt 95460 ctcaattcat ataaaaccgc atccaggcca tcatcagtaa ttctatatga caaatgctcc 95520 ttctaacaac cccaaaatct ttcttcagtt gaatctctcc cactgtaggt tcccacaccg 95580 cccctgatcc cgctcgaagc agccttgaga aacatcgccc attatctctc cataccaccc 95640 ccaaaatttg tcactgctcc aacacttcac cactattttg ttttgctttt cttattaata 95700 taagaagaca ggaatgtcag ccctctgagc ccaagctaag ccatcatatc ccgtgacctg 95760 catatacatc cagatggcct gaagcaactg aagatccaca aaggaagtga aaatagcctt 95820 aactgatgac attccaccat tgtgatttgt ttctgcccca tcctaactga tcaatgtact 95880 ttgtaatctc tcccaccctt aagaaggttc tttgtaattc tccccaccct tgagagtgta 95940 ctttgtgaga tccaccccct gccggcaaaa cattgctcct aacccaaccg cctaccccaa 96000 acctgtaaga actaatgata atccaccacc ctttgctgac tcttttcaga atcagcccgc 96060 ctgcacccag gtgaaataaa cagccttgtt gctcacacaa agcctgtttg gtgggctttt 96120 cacacggagg cgctaacaca aggtgtataa gaaaagtaaa tatacctttg gtaaaaggat 96180 tataagaagg cataagaatg taaattttta cctagattaa aaggttaaaa aaattgtttt 96240 gaaggtttaa gcaagtttta aaacattaat tataaaaaaa ttctgtgtgt aaacgtatta 96300 gctaaagtta aaggggtatc atccagtttt tctgtgaact ggacattaaa gtaaaaacac 96360 aatgggtttt tcttaaagca ctaacttgct ctttaacaaa gattataaaa ggttaaaaag 96420 agtctataaa aatcttacct tacggtctga cattaaaaat tgaataaata tgtatacaaa 96480 gttttattaa aactaagttt aacattaata gcacactaat ataaaggtga aatttagctt 96540 atctggtata aaaatcatac agaaagcatt attaaatata aaacagtgtt tggctttctt 96600 tggtccaaaa actaataaaa ataggtggta aaggaaattt ctcagtaaaa aggcaccaaa 96660 gcctataaag tccactcttg atgtccccac atttgaaaca aaaaatcaat ttcttagaaa 96720 ttatatactt ggtttgtctt ccactttcct ttccctcaaa actaaaagcc ttttagcaca 96780 ggtgccagcc ctagaatttc cagtaaacca gcaccagcct gaagatcacc ttcttatcaa 96840 agggaggaaa gaaaacaaat ttttcaaagg aaaagttttt cttatcaaag gaaagaaaga 96900 aaacaaaggg aggaaagaaa acaagccagc ctaggaagga cccgaccttg tgctgctaac 96960 caccgagact gctgtcccta cagtggaaaa gggatggact catcacaccc gagtcaaagc 97020 tccaccccct ccggagtcgt gggccccagt ccaaggggaa aaccctacca aactaaagct 97080 aagaaatatt taactctttt atctattcta ttactctttc ttctttcctc gctctattgc 97140 tgaccatctg gttattaaca caaccaaatc aatttcacct caaactattg catttaatgc 97200 ttgtcttgtt ataccctgtg gggacttgcc aagtcgaaga cagctctcta cttcagaaaa 97260 gtacttctgt ccctcctgac tctcctcaga ctgggcatta gtaaattagg accatttaat 97320 ccgggggaat ttcaataaag actccagtgt caaccaggag tcttgctccc caatgtagag 97380 cttttatgcc gtagttggtc caacattctg tggaccacta aagagcaaga atggactgcc 97440 ccaaccagtt tttgtaattt cccaaaatca tacattcatt ttactagaag ttcatattag 97500 ttaaagactt aaaacaaact ttggcaatta agacagcata ccaagatgca aatgcctggt 97560 tgaaatggat caaatattcc atccgcacgt taaacaaaag caactgttac gcttgtgcac 97620 atggcaggcc agaggtcctg attgtcccct ttccactaag gtggtcctcc agtcgaccag 97680 gtgtggctgc atggtagctc ttctccagga ttctacagcc tggagtaata agttgtgcca 97740 agctctctct gctgtatccg aaagtctggc gccttgcggg tcagcccccg agggccatcg 97800 agccgccgtc tcccaatact aagttcactt cgtgtctctc atgacaggga ggaaacttag 97860 cattccttgg aaacctgaag ggatgcagtg agcttaaaaa ttttcaagag cctatcaatc 97920 agccagccct tgttcatccc tgagtggatg tgagcggatg tgtggtggta ttgtggtgga 97980 cctttactgg gcactctgcc gaataactgg agtggcgctt gtactttagt ccgattggct 98040 atccctttca ccctggcatt ccatcaacca gagggaggaa aaataagaca tcgtaaagca 98100 agagaagccc cttatgggtc tttcgactct catttccatt tagacgcaat tggagtccca 98160 cggggaatac tagatcaatt taaaacttga aatcaaatag cggcaggatt tgagtcaata 98220 ttttggtaga tgacagttaa taaaaatgta aattggataa actacatcta ttacaacaaa 98280 cagcaacaag cttttcatga gttaaaagaa aaacgtaggc cccagccctg gggctatcag 98340 acctgacaaa accctttaca ccctatgtgt cagaaagaga aaaaatgcag ttggagtttt 98400 aacccagact gtgggaccct ggctaaggcc agtggcctat ctctcaaaac aactagacgg 98460 ggtttccaaa gcctggcccc cgtgtctaag ggccctggca gcaacggccc tgttagcaca 98520 agaagcagat aaactaaccc ttggacaaaa cctgaatata aaggcccccc acgctgtggt 98580 aactttaatg actaccaaag gtcatcactg gttaacaaat gctagattaa ccaagtacca 98640 aagcttgcta cgtgaaaatc cccacataac cactgcagtt tgcaacacgc taaaccccgc 98700 caccttgctc ctgatatgag agagcccagt tgaacataac tgtgtagagg tgttggactc 98760 agtttattct agcaggcgca acctccgaga ccatccttga acatcagtag gctgtgagtg 98820 gtacgtggac ggaagcagct tcgccagccc ctgcaaagtg actctgagga agacgacaag 98880 ccctgctcca gtcacaactg gaagctgact ggtccacaca cggccgaagc atgagaaaac 98940 tcatcgtggg actcattttc cttaaaattt ggacttgtac agtaaggact tcaactgacc 99000 ttcctcagac tgaggactgt tcccagtgta tacatcaagt cactgaggta ggacaaaaag 99060 ttgccacagt cctattattt tatgattatt gtaagtgtac caggactcta aaaaaaaaaa 99120 aagtttgtat aatgctattc tatgcaaggt atgtagccca agaaatgacc aacctgatgt 99180 gtgttatgac ctgagtctcc catgaccaca gcttttgaaa taagattaag gactgaggac 99240 tggtagggac tcataaacga tacgagtaaa gtgttagcca aaatgaaaga aaaaggggtg 99300 cccaaacaag tcactttaaa gtttgatgcc tgtgctgtca ttaatagtaa taagttaaaa 99360 atagaatgtg gttcccttaa ttagaaaaga ggccatatga caaaaaataa gtacatttgt 99420 cataaattaa aactgtgtgg aaataaatgt aaatactggt cttgtgtcat ttaggctact 99480 taaataaaaa ataaaaagga tcctgtccac cttcaaaaag gaaaaagtgg cccttcctgt 99540 accagtggtc agtgtaaccc cttagaacta gtaataacca acccccttga tcctcgctgg 99600 aaaaaagggg agcatgtaac cctaggaatc aatggggctg aactggatcc ttgagtaaat 99660 atcatggttt gaggagaaat ttataaacgc tctcctgaga cagtatttca aaccttctat 99720 gatcaactga atgtgcctgc accagaaatt ccaggaaaaa caagacattt gtttttgcaa 99780 ttagccgagc atgtggccca gtctctcaat gtcacttcat gttatgtgtg tggacgaact 99840 gtaatgggag atcaatggcc acgggaagcc cgagaattag tacctacaga cccagttcct 99900 gatgaattcc cggctcaaaa gaatcaccct gataacttct gggtcctaaa agcctcaatc 99960 attagacaat actgtatata gcaagagtgg ggaaggactt cacctttcct gtgggaagac 100020 tcagctgctt aggcaaaaac tgtataatac tactacaaaa acagccacct agtggagttc 100080 aaaccacact aagaaaaatc catttagtaa attcccaaag ttgcaaactg tgtgaaccca 100140 cccggagtcc cacagggact ggacagcccc cactggatta tactggatat gtaggcatag 100200 agtttacacc aaattacccg accagtgggc aggtagtcat gttattggca ctattaaacc 100260 atctttcttc ctactgccca taaagacagg cgaactcctg ggcttccctg tctgtgcttc 100320 ccgcaaaaag agaagcatag ctataaaaaa ttcaaaagat aatacatggc cccctgaaag 100380 aatcatacaa tattatgggc ctggtactta ggcacaagat ggctcctagg gatacccgac 100440 ccccatttac atgctcaacc gaatcatacg gttacaagct gtcttagaaa taatcactaa 100500 taagaccggc agagccttga ctattctggc ctggcaagaa actcagatga gaaatgctat 100560 ctatcaaaat agattggctc tcgactactt gctagcagct gaaggagagg tctgtaaaaa 100620 atttaacctt actaattgct gtctacacat agatgatcga gggcaattag ttgaagacac 100680 agttagaaat atgacaaaac tggcacatgt gcccgtgcaa gtgtggcatg gatttggtcc 100740 tggggccatg tttggaaaat ggttcccagc actaaaaaga tttaaaactc ttatattagg 100800 agttacaata gcaatagaaa cctgcgttct gctcccttgt ttgctaccca tacttcttca 100860 aatgataaaa agcttcatcg ctaccttagt tcaccaaaat gcttcagcac aactgtacta 100920 tatgaatcac tatcgatctg tcttgcaaga aaacataggt agtaaaaata aaagtgacaa 100980 ctcccactac tgagtgagat tctcagagag ggagaataag ggagaccacc cctcatattg 101040 ttttacgccc aatttctgcc tccaaagaga gaagtaaaaa ctaaaaggca gaaatgaaat 101100 ccacaagcag acagcctgca ccacaccctg ggcctggtag ttaaagatcg acgcctgacc 101160 taatcagtga tgctatctat agattacaga cgttatatag aaaagcaccg tgaaaatccc 101220 tgtcctgttc tgttccgttc taattacggg tgcatgcagc ccccagtcac gtaccccctg 101280 cttgctcaat caatcacgac cctctcacgc agacccctga agagttgtga gcccttaaaa 101340 gggacaggaa ttgctcactc ggggagctcg gttgttggag acgtgagtct tgccgaagct 101400 cccagctgaa taaagccctt ctttaactcg gtgtctgagg ggttttgtct gcggcttgtc 101460 ctgctacact ctggtgggaa agacaccgca gcaggggagc agggtgcgca gggtgcagtg 101520 ggtgacgctc attcgctgaa aactgaccct gctttcaaag ccttgtcagt tcccaaagct 101580 gtatgaagcc tttcctgagc ctcaacctct agagtctaat ttcatcctct gtattttccc 101640 ctttgttagt ccaaactgcg tcattttgta agcccctttc cattttgtag accttggtca 101700 aagtgaaaca ttccacgggg gttcgagcca tgagaaacag cctgcctctt aacatattct 101760 gctgggacaa agcgccagga acaccacatt ctgccggaac cacctcatcc tgggaacacg 101820 ttaacatctt cccggacagc aagccatact gcctagatcc ctcctgccca ggcctatgag 101880 taccccagcc tgtaatcgct ggtgggctct ggcattaagc tggcccccga caggtgtttg 101940 caatacacct gtgttgctgt agagccgccc gcgcgccggc aatctcactg tgcgtcattc 102000 tttaaccttc accttccctt caaaacctaa cacccttgac gtttatattc aggctattat 102060 atatacatac acacatacac ccttctgaat cctcccagga gaatataaaa ccatgggtta 102120 aactgctaca cttcagcttc agtggctgcc tttcagtgct tcaaatacac caacctcttt 102180 cccaccccgg gacctgcacg agaaagctgc tccactcacc cgccgtgctc tttcactcac 102240 ccttcaggtg tcttcaatat cgcctctcag gcctttccca accaccggtt taaagtcggc 102300 tccccacaaa taaatacata ttctccctca cagtacttcg cacaacacct ggcacagcga 102360 gagcactgaa ccaacactca ttcaatgagg aacacgaggt aagaaccaag accccccaag 102420 gtcgccgtac tttgtctggt aggagaagct ttctgcccag caaggtccga cccagatgaa 102480 accccgtcca agtctgcagc acccccgtga gtccagcccg ctaaactgtg aagaatttaa 102540 atacacgaca cctgccctca aaagcttgag ggcacccctg agctgccatc gaggtggggg 102600 cgtcaacgac aggcgctcag taagtgctcc tgaggcaact gccgggctgt cctggacctg 102660 gtgaatcctt tcggggttca gcaaaggcgg acgctgaccg ggccaaggag tgggacctgc 102720 agtgctggac cacccttttc caagcgcaga agtgccgtgc ccgccggctc tcaacagggc 102780 aagaggcccc tctcgccgtg cagagcgcag cgcttgcggc ggggacagca gaggcgggac 102840 gggcgtcacg gagttcccgg gtcctcgcgc ggtcacttac ctggcctcag ctatccgctg 102900 aaaaaggggc ggacggcctc ccgggatccg agccgatatc gcgcgcggcg ccgcggggca 102960 acctgaagcc gtgtgcgtgc gtgtgcgttc acgcaggggc tcacccagcg gccacgggct 103020 tctgaagacc cgggtgggaa gtgcggcccg ggaaagcgca agcgtctcca tggcaacgag 103080 ggcggacggc gtcagagcga gtcgcttccg gaagtgacgt gcggaagggg tgcccgggac 103140 gaagccatgg ccctggaggc ggcgggaggg ccgccggagg aaacgctgtc actgtggaaa 103200 cggtaatgct gtcaggcgac gcgcaggagg cgggggccga ggccgggcgg cccttcgcgg 103260 accctccgag ctcatagtct tcaggctgtg gaatcggagc tgccaccgcc cgagactcca 103320 aagcaaagcc cagtttccgg cgcggaagcg gagggatctc aggaattgta gtccgcgggg 103380 tgggcgcggt tctcgcttcc ggccagtttg tctggcctgc gcttgcgcgg gtctccgccg 103440 cctgggctcc tagggactgt ggcctcggcg gtatgtccct tgctttccct tgaagcggga 103500 gaagacccgg cagaggcgct ctgtccgctg cagccgcgcg ggtggaggag gcagagtctg 103560 aggtgtgacc ccgaccaagt ttgacgcttc tgtcctccta gggagcaagc tcggctgaag 103620 gcccacgtcg tagaccggga caccgaggcg tggcagcgag accccgcctt ctcgggtctg 103680 cagagggtcg ggggcgttga cgtgtccttc gtgaaagggg acagtgtccg cgcttgtgct 103740 tccctggtgg tgctcagctt ccctgagctc gaggtaacct gggaggacgc cgagctcgag 103800 gcgggcccct cggtgggctc gggcgtgcgg tctccgggac agggagcagt gcaagcgtag 103860 aacccggctt ctcgttttgt aggatgtcat taatagtctg gggagttggc cgggcgcggt 103920 ggctcacgcc tgcaatccca gcactttggg aggctgaggc gggggaatca cctgaggtcg 103980 ggagttcgag accagcctga ccaacatgga gaaacccggt ctctactaaa aatacaaaat 104040 tagacgggtg tggtggcata tacctgtaat cccagctact cggaaggctg aggcgggaga 104100 atcgcttgaa cccgggaggc ggaggttgcg gtgagccaac atcacgccat tgcactccag 104160 cctcggcaac aagagcgaaa ctccatctca aaaaaaaaaa aaaaaaaaaa aagtctgggg 104220 agtcttggaa gggaaaaaaa ggcaaaaatt aagggaattc tgtgactatt aagaatcagc 104280 tcatgagctt tatcttcaag tctgattgtt atcttgggtt cttcatctca gtgacctgtc 104340 caccacgctc ccagttgccc aagctggaga tctgcatcct cctgggcccc tccgttcctc 104400 tcgcgtccag ttgcacacta gctcgctttt attctgcctc ttaaatgtcg ctggaatctg 104460 tccccttgtc tgtttcccct ctgctccttc cctggctgtg ccaccatcac tcctgtgggt 104520 tcctgagcag cattttcatg ggtgccctgg ctcaaatgtt cctcctcagt ggtttctttt 104580 ccatactgcc agcagaccaa ttttcctaaa aagcaagtat tttcctcaaa agcaacaagt 104640 cccctccctc cctccctccc tcccttcctt ccttccttcc ttcctccctt ccttcctctc 104700 tctgtctctc tttccttcct ttccccttcc cccactctgt gcccaggctg aagtgcagtg 104760 gcataatctt ggctcactgt caagatctga tctcaacctc ctggactcaa gtgatcctcc 104820 caccttagcc tgagtagcta ggaccacagg tgtgagccac tacacccggc ttattttttt 104880 attttttgta gagacaggat ctcactatgt tgcccagggt ggtctccagc tcctgggctc 104940 aagggatcct cctaccttgg cctccccaag tgctgagatt acaggtggga accaccacac 105000 ccagcccaca agtcctctta gaacattgaa gtgcccttct catgacctca tggtgaataa 105060 agttcactct ggttggcatg gcttcaaggc ccgtcatgac ctgtcccctg cgtaatttaa 105120 tatgacgctg gaggctcagc cctcaccact attctcagtt cttcccacct cctacagccc 105180 actgtgagtc cctcacgtgt ttgctacgct gtatttggcg gcctgacctt tgcagtaatg 105240 tttcttctgg aagggtttcc atctggctaa ctactactca tctctttggg ctcagtttag 105300 acatgacgtc ctccactaag ctccctctca tcccacaaga cgaggacttg tccctcagca 105360 ccatgtctta gtccgtttgg gctgctgtaa tagaatacct tagactgggt ggcctaccca 105420 cagcaggaat ttatttctca cagttctgga ggctggaggc tcaagatcag ggtgccagcg 105480 caatcaggtt gtggtgacgg cgctctttca ggttgcacag ggccagcttc ttaaccgtgt 105540 tctcacatgg tgatccactc acctccctag aggccccacc tcgtaatacc atcacctatg 105600 ggttataatt tcaacatagg aatttgggga ggacaccagc atttagaccg tagcaaccct 105660 ctgcttcctc ttgtcttgct gggatggaac tggcctgtct tccctactgg aatataaact 105720 ccatgatggt agaaaccatg ttgctttgcc caccatggat agcatgagga agacgctgga 105780 ctcttccttc aagagatacg tgtgtgaatg gacagtgggc tcatgattca cataagagtc 105840 aacagctccg gaagcctctt ggcgtcactc gcattgctcc tctgctgact cccgaaggtg 105900 acaaacgtct tcctgcttcc atggctttgt gctttacttg ggaggccctt ttcagtccaa 105960 atcaagcaaa aatgtactga gtgcctactg tgtgctaaga ttgggatatt cagcagcccc 106020 tactctaaga ggtcccctgg ccattgtgta ggctagcata gggagtgggg acacagtctt 106080 agggtcctga ctactcatgc tcacacccaa ctctgccact ccccactttg ccctctaggc 106140 ctctgtctcc ttttttctga cttgaggatg atagtggtat taatatccag ctcacagaat 106200 tgtgatgagc agtacatgaa atgcatggaa agcagttaac acagcattcc cttccccctc 106260 caacttctcc tggctgcaaa ttaatcacct catctgcatc ctgggcctct tttgaatgca 106320 catgctgtta gagcgcttct cacattgtat taaagttagt catttatgat tccatttttc 106380 ccactgactg taggttctca agagtagggt gtaccatatt tcttttacaa ccccagcacc 106440 aagcaaagca cctgctactt cgtcggtatt cattgttccg gctatgaaag cttagactag 106500 gaaaggatct tggaacagtc tggtccactg gttcctgaat gcccgaccgt ggacctgcag 106560 gagcagaatc acccagaagt gtgttgagaa acagattccg taggcacatc cacagagaca 106620 gaaagtggat ccttgggcct tggagttggg gtgggatgga tgggaagtga ctgctgatga 106680 ggatgaggtt tatttagggg ttaaggaaaa tgttctaaag ttagattgta gtgatattgc 106740 acaactctgt aaataccaaa accatcgcat tatatgtttt aaacaagtga actttatggt 106800 atgttaattg tatctcagta aacctgttag gaaaaaaaac aggccgggcg cagtggttca 106860 tgcctgtaat cccagcactt tgggaggctg aggcggctgg atcacgaggt caggcgatcg 106920 agaccatcct ggctaacacg gtgaaaccct gtgtctacta aaaatacaaa aaaaatcagc 106980 cgggcatggt ggcgggcacc tgtagtccca gctactcggg aggctgaggc aggagaatgg 107040 cgtgaacctg ggaggcggag cttgcagtga gccgagatcg cgtcagtgca ctccagcctg 107100 agcaacagag caggactctg tcaaaaaaaa aaaaaaaaaa acagattcca gagccctacc 107160 ccacttactg ggggaaaaac tctcccagag tatagcataa gaatctgctt tttaaaataa 107220 gctttcctgt gattctgaag cagagctggg ctggagaacc actggcctgc ttttcccacc 107280 gtgaagaaca ctgtccttag catccctgac aaacgatggc ggagcccgtt ctgtgccaga 107340 tgctgagcca tggctggtgt gtgctgctcc gcaggcctct ggcggagccc attccatgcc 107400 agatgctgag cgatggctgg tgtgtgctgc tccacaggcc tggtggagcc tgttgtgtgc 107460 tggacgctga gcaatggcta gtgtgttctg ctccgcaggg agctgactcc tacttgtctg 107520 tgactcccat cgatcagttc tgccttcagg tagcaaaaca gaacggatct tccctgcctt 107580 ctgcttgtca gcccttctgc tgctggaaac agctgcctgc tccttgacca cactgtccca 107640 agaggctgcg atgacgtcca gcttcttcac tggtcagtgg ccctctggtc atgccctccg 107700 ttcacacaat ccatctttcc gtctgcactc agaatcaaat gcaggaactt ggatgtggtc 107760 tacccaagtc cctagaccta actgtcaccc acgccatttc agtcggtgta gctggaaaca 107820 ctggtagctt ttgaggggca ccaggtcact ggcttatgtt gagattgctg gtcatccaga 107880 cctgccccct acgctaatca tacagtgatt tttcttttcc cagattttta atttgaaaat 107940 gtacatacat ccccccaaat tggaaaagga tacgttggac acctgtattc cttctactta 108000 ggttcagctg ttgctgctct ggaatattct ctctcgcgca catgcgctct ttgtgtgcgt 108060 gtgtaccgta catcccagcg actgtgacag ctcagaagac atcagcaggc ctgtcctgag 108120 aatgacattc tcctccacag ccacagtgtc attatcatac tgattacaca tcatagtcat 108180 cccataatgt cacctgaatg ataacattat gggagagatt cagatgtaag cagccacgcc 108240 cctcctgtgg gaactcaggc cacacttgaa ttccacatgt cactgtgcaa agtgactttt 108300 actctgtggg gatgtcagtg atccagcctg ctggcttctc tgtgaaccca aattctgtta 108360 tcagaatgga ccctccccac tttgggtcat gggcagattt gatcagtttc cccattgagt 108420 cattgatgaa gatgttgtga gaatgatccc caaccctctg tgctaataca gagcactccg 108480 tctgctttgg tgtgtttaat tattgatcca gccacaagtg aggagtggaa gttgtgattt 108540 gaaagctgtc accaagagat ttgggggatt cagtaacaaa actgcaggaa ggtagacagg 108600 tctgcagaat gtggacatag tgggaaacgt cttcacatta agggcagtgt gactaaggaa 108660 aacacaaggt taggagactc aggcctgcca tgttgtgctc taaactgcag cctctgcctc 108720 ctgggttcaa gcagttctcc tgcctcagcc tcccgagtag ctgggattac aggcatgcgc 108780 caccacgccc agataatttt gtatttttag taaacacggg gtttctccat gttggtcagg 108840 ctggtcttga actcccaacc tcaggtgatc gtccgcctcg gcctcccaaa gtgctgggat 108900 tacaggcgtg agccaccacg cctggccaac actgtgtctt ctttaagcct ccaacaaccc 108960 atggaggggt ggggtggggc atcggcttca atacacaaag gaggagacac caggaaagca 109020 aggggcaggc agaggtgatg cagccagcag ccttagcctt gcttctgatg aagaccaggt 109080 cctggggggc tcccgcggac ctgatcccag ggaatcctcc tatggaccag gtcccggagg 109140 ctcctcctat ggactagatt ccagggaatc cttctacagt ctaggcttca ggggctcatc 109200 ctatgaacta gatcccgggg aatcttccta tggaccgggt cccggggaat cctcatacag 109260 accagatccc ggggaatcct cctatggacc aggtcctggg ggctcctcat acagaccaga 109320 taccagggaa tcctcctatg gaccaggtcc caggggctcc tactatacac atcaggtctg 109380 ggagttgggg ctcctccagt ggaccgggtc cggggtgggg gttctcatat ggaccgggtc 109440 ccagggggct gctgctatgg accaggtccc ggtgggggcg gggtgggggt gctgttgcta 109500 cagaccaggt cccgggggag ctgctgctac ggaccaggtc ctgggggggt ctgctcctat 109560 ggaccaggtc ccgggggtac ctgcccacca ccaatttgca gggtacatct tctagttcct 109620 tcttccaaac ccatcatctc ataggtgagg cagggaaggg gagccatgag ggtgacgtaa 109680 gggagaggga aggatgaggg gggcagggca tggacggact ggggatggag caggtggccg 109740 aaggctgtgc ttcccactga gctgcgtgcc tggtgtcagg tggtgtatga ggagagccgc 109800 atggtcagcc tcacagcccc ctacgtgtcg ggcttcctgg ccttccgaga ggtgcccttc 109860 ttgctggagc tggtgcagca gctgcgggag aaggagccgg gcctcatgcc ccaggcaggt 109920 gtctcatccc taggacgaga gaaaggtccc tccttccccc tgggggaggg aaggctgctg 109980 caggtcgcca ccaccacagt ggcagggaga gactcatgag cttcctggaa gagaggaatg 110040 aggatttcta aaaagctgga ccccagagac agtgccccct tcttgcctca gggatggccc 110100 tgtcctgagg gccgaggggc agctcagctg actgtgactc tccctgtggc tccataggtc 110160 cttcttgtgg atggaaacgg ggtactccac caccgaggta atcctgctct tggaggtcca 110220 gggagggcac tgtggggaag agcgggggga gagggcacct ctgtcgtccc ccacagaaaa 110280 tgctgggccc tcggcctctg ccgccagccc cctccaatgg cttctttctc ggcgcaacgg 110340 ggacgcgcag tgcgctcagc cccgcctccc ccaccgccgg taaaggactg tctactttcg 110400 cttcacccct tacctctttc ctgtccgcca ctgccttctc tacagtgccc tgtgctggct 110460 catctccagg tgccactatc cagttctgac ctgatcacca aaagatgtcc cagggcccgg 110520 gctcagagtg gccttccctg ccagccgccc aacctgcatg gcccgtcagg ccccttgtcc 110580 acaactagac aggtgtaccc aggcccccac tgatgccagg aaccttggcc tagggagcgt 110640 ggctgaggga gatgggctct tttttttttg agacggagtc tcgctctgtc gcccaggctg 110700 gagtgcagtg gcgcgatctc ggctcactgc aacctccgcc tcccgggttc atgccactct 110760 cctgcctcag cctcctgagt agctgagact acaggtgccc atcaccacgc ccggctaatt 110820 tttttgtatt tttaggagag acggggtttc acgtgttagc caggatggtc ttgatctcct 110880 gacctcgtga tccgcctgcc tcggcctccc aaagtgctgg gatttcaggc gtgagccacc 110940 gcgcccggcc tagggagatg ggctctttta ctgttacata cagagctgcg ggcggcgcag 111000 cagcacccag agagggccca ggaggggtga cattgggcct tcctggccag caagtgtgac 111060 tcggccctgg ctgctgccct cgcacatggg tgcagagcca aagggttgtc atgtgccgac 111120 ccacatgctc gtgccagcgc tggcaggcca ccgtcgaggg aagaggaagc tgggaggtgc 111180 aggaaatgac cggagagctg cagtatccca gcacgccagc gaggtgctga ccctggcact 111240 gaccgtgtca gagagaagga ggcttcctcc acggccttgc acccaggaca tcgggcacag 111300 ggggctttcg cccaggtctg cttgggactt agatctggtt tccccagccc tctgcctgtc 111360 cacagacctc tgctcactta gggaagcttt tggtaagact ggcttgtcct gaatccctgt 111420 gccaggcccc agccccacct ccccaacccc accctccttt ctctctggca ggctttgggg 111480 tggcctgcca ccttggcgtc cttacagacc tgccgtgtgt tggggtggcc aagaaacttc 111540 tgcaggtgga tgggctggag aacaacgccc tgcacaagga gaaggtgagg aggggcctgc 111600 tgcaggccat gcccggcagc tcagtggcgg ggctgtggtg gccctgggca tgaggacact 111660 tctggaccag cccttgcctg ctgacgctgc cctcctcatc cctggcttgt ggcctggagt 111720 aagaaagacc tgctttcctc tgggtgctgc attgcctgtc tcagctgagg gcgctctgag 111780 ctcctctcct gcctcctggg tgtgcctgcc tctctggtcc cccttgcctc tgagccaccg 111840 tggcacacca agtagggcta agtcctccag ttactgggga caggacgggc ttccaggctg 111900 tcccgggcgc acttggtgct ttccccaccc cgccttgccc cagcccctgt ctcctcccct 111960 gcatgctcag gtaccacagc ctccaggccc ccctcccgcc aagacctgcc tggagctgcc 112020 acccacactc ttcctacctc accttcccct gcatcttcct cctctgggac cccatgttgg 112080 cactgggagt gagacactca caatggaggg agctgttgac acccccagct gtttcactgg 112140 atggcagatt ctgagagcag agactgtgtc tctcattcct cctagctctc aggtgcctgc 112200 atggagaagt tgcttaataa aaatctgttg agttgatggg gaccttagac ccactcaatg 112260 agccagtcca ccgccgccag aaataccagc ctgttgagct gtgtcagatg tgcccaaagc 112320 aggagagaag ccacaggaag gaagcgggct cagcacccat cactgggcag tggcggcacc 112380 tgtgtggctg ccagcctggc acagcggccc tgggcagatt gttgcccttg ttctaagccc 112440 catcatcagg tttgaacagg gtcttgtggg cagcaccctc agctcaggga caagaccact 112500 tcaccgcctg cacgctcagt gtcgtctcag gtggtgtggc tttgcctggg ctgtggctca 112560 cctccaagat cagtcccctt ccctttcctg gcccagtgac tgggttttaa aaataaagag 112620 acctgggccg gttgcggtgg ctcactcctg taatcccagc actttgggag gccgaagtgg 112680 gtggatcacg cgattaggag atcgagacca tcctggctag catggtgaaa ccccatctct 112740 actaaaaata caaaaaatta gccgggcgtg gtggcacatg cctgtagtcc cagctactca 112800 ggaggctgag gtgggagaat cgcttgaaca cgggaggcag aggttgcagt gagctgagat 112860 cgcgccactg tacttcagcc tgggcaacag tgcgacactc cgtctcaaaa aatagagact 112920 tgccttcagc ccttcaccaa gaagagaggg gtttttttcc ccatttttcc ctccattttc 112980 cagatccgac tcctgcagac tcgaggagac tcattccctc tgctgggaga ctctgggact 113040 gtcctgggaa tggtgagtag ctagggccct gagctcctcc aaagccccgg ggtaggggat 113100 cctttgcagg cagacacagg tgcatgcaga cacgcgtgca ctcacacttg cccacatcaa 113160 ccccccgcct gcccgtccat ccatcctcct gcctctgact gagtccaggg tgtgatgttt 113220 gtgtttcttt cctccagccg tgctgaggga gcccaccctc ccccagggac aagcagcagg 113280 aaggcgccct gagggtgggc aggccctggc ccctgagagc actgcccctt cagcttcccc 113340 cttgccccca ggacattttg tcagagctcc agctgctgag gctgtcctga ccctggtccc 113400 ggtggcccag cccacaggac agccctcgcc ttccttgtca caggccctga ggagccacga 113460 ccgcagcacc aggcccctct acatctccgt gggccacagg atgagcctgg aggccgctgt 113520 gcgcctgact tgctgctgct gcaggttccg gatcccagag cccgtgcgcc aggtgggtgt 113580 gctggggatg cggggaggca gcacaggctc ctctgcttcc tgccacctgc tgttcagggc 113640 tccccagcag ctcagctggg gtcagagtgc agtgacatga ggacgggggt tcctgggccg 113700 aggacaggtc acagacatct tgctggagag cttgctgggc cctgcagtca ggacagtaga 113760 ctggggggtg cagggctccc aagagttcat ccccaggccc tgcaccccat gcactcagcc 113820 tcccagcctc tctgagcctc ctgcacccag atacaggcca gcttggagaa tcagtgatgt 113880 tagctcaggt ggtgaggtgt cctgccagtt cccagccagc ccctcaggtc ccagagggag 113940 cagctgaact tgagccagga ggctcctgca ggaaagctgt gcaggcccca gagacgccag 114000 tctggggact tgggtatgcc cgccccagga cccagcacaa aactggtgtt cggtccccca 114060 ggaagggtga gaactctgct gaagccatca gctcagctga gaaaggactc agcctgtggg 114120 ccagggagag acagctggca cgagatgccc acagacagcc tcgataggac caggggacca 114180 caagacacgg gtggatgctg tcccagagaa gcccacagag tgagggttca agaaaagtca 114240 gtcttaggaa gagacccgct ggaggaaggg gaaggacagc cctgggcagg aaggagtttg 114300 atgtgctcaa gaaatggggg gcccggaggg tggctcacgc ctgtaacccc aacactttgg 114360 gagacagagg tgggaggatc acttgagccc aggagtttga gggcgcccta ggcaacatag 114420 accccgtctc tacaaaaaaa acgtaaaaac aaattagcca agtgtggtgg tgcgtgcctg 114480 tggtctctgc tacttaggag gctgaggcgg gaggatcacc tgagcccagg aggtcgaggc 114540 tgtagtgtgc cctgattggg ccactgcact ccagcctggg tgacagagca agaccttatc 114600 tcaaaaaaac tttaaaaaac aaaaactcag caggaaggtg tggccggagc cagatggcag 114660 tgaagtacag agtgggtggg agcccgtgag catcttgggg tgcgccaggg tttcagacgt 114720 cacccacagg gacttggatg gctgtgagtt ggcagcgggg cgcccgcaga ttggcctttt 114780 taggtggccg ctgtgcgtgc tgtggaggct gtggacgcag gtctgcacaa gccatgctgc 114840 ttccagcagc ccagcccctg agcctccctg gtgtctgccc cttccccatc ttaccccacc 114900 gcttgccctg cagcctgccc tggggcagcc gcagcaccgg tggaaaaccc ccaggccacc 114960 accttcgggc cggggccttc cggctgctgg cgcgcagtgt ggcctccagg gggcagcagc 115020 agcccacata ccacaatggc cctcgccctg gggagctgtg ctcagtggtg gcgtctgaga 115080 gcgggctcca cagccttgca gggctttgct cagggcacag gtgtgtggac tctcaagcct 115140 gtgagctgtg tccccagccc ccaggaaaga ggcctttctt cctccattcc aactcagccg 115200 tgtggtcttc cgagagagaa cccaagaaac tgtcccccag gccttcagcc acaggaactt 115260 taggtcgtgc tgctgctgca gacagcacag ttcctggagc tcctgtacct ttttctgcct 115320 cagcgcgccc cagagtagga cagtggccca tccttgcaag ggaggggaca cctggcctgt 115380 gagtacctta agcatctaga aatagagcaa ggatctgtgc ctagcaccag caaagagcct 115440 gccaaatcct gggcccaccc tccagaggaa ggaaagccgc aaccagttgg gatatgcagc 115500 caccccgtac caggagcccg cagcttctta ctgttgggcg tgagccgagg atcgtgtcct 115560 gcagggctgg ctctgtctct cggtccattt tcttcctgag ctcactcacc tctcaacagg 115620 ttcacctcct gctctgttcc agaaggtcct gggagagcac agacggggtt agtgttggtc 115680 tgctctctcc ctggctccgc gccgggccgt cttggtggcc ccatggtcac aggcgctgcg 115740 gcgctcctgg ttgccaggtc caggctctcc tgccaggcca ggctgggccg ctccagggga 115800 aggtgagagg tgctggcccc gcctaccgct gccccacttc ccccatgaat ggaagcagga 115860 gcaggctggg ggattagccg ttgctttcca tgagtcgtgc agccctgaag ctaatctaag 115920 ctcatctgag ctgggatcag ggggacttcc cagggccaga ccccccatgc ccccgggggt 115980 tcccactcag acctgagccc tgttcagtgt ccctccctgc tagggtctgc ccccatccca 116040 gcctgtggcc caccgccctc ttttatcttg gtgattctgg agacgggaca ggggttactg 116100 ctgatctagt cagggagagg acagaccagc tgggctcaga gcccccagag aagcaagtgt 116160 tagcagggaa gcctcggctt gcgcagagcc tacagggaag cacagactgg aaaccagtga 116220 aggctgagca gctccaactg ccactggtgg ggaggagacc caggaccccc tcactcagcc 116280 tgtccactca ccagctactc aggcccttca gggactgccc agctcggttt gagagctgcc 116340 attgcggggc tttgacccca aagtcccagg catgcctgtc ccacactcgc tgacagggcc 116400 gcggctcctg agcctgaaga actggctgtg acctgtgtgt cctgagtggg cttctgtggg 116460 ggatggaggc attgccagca gcagctcctg gtgggaaact ggtctagaga ccagctcagc 116520 acccagcagc acgtctgtct cccccaggct gacatctgct cccgagagca catccgcaag 116580 tcgctgggac tccccgggcc acccacaccg aggtgagcac ccagggaggc tggggcacta 116640 aaggggcatc tcacagacac ctgcatgggc tgtttccggt ggctcagcct ctccttgttg 116700 caatattgtg gctcaggaca gacagtgcag ggccagggaa ggcaggggac acaggagagg 116760 tcttcaaaga gggaggagag tggagtgggg tagactccta ttctcgtggg aactctccag 116820 aaacaccact gcctccacgc aaagccctgg aactacggcc ctgtctggtc caagccctac 116880 ctcccaatag ggctatcccc agccttcctc agtccactta gcctgtgagg taccaggacg 116940 tgggctctgc agaaaaggcg tggcctcgga gtcagacatg atccagccct gcatagccag 117000 ctgtggcgtt tgcactcttc gagcctcagc ttcctcatcg tcgggatagg ctctgtaatt 117060 cttgtcccac tggttcttgt aagttagagt gacagtgtgc ctggcacagt caccgctaac 117120 agtgcaaggc attgtcttaa aaccattgca gatggtttga tcctgctagc aaccttgatg 117180 tgagacaagt actgtgaccc cactttacag atgaggaggc tgggacactg agtgttgata 117240 aggagtaaag cagaattcag tctggctact tcctcttctc tcagtgtggg cagtttggat 117300 tccaggccct gcatctgagc ctccaggctg agaggacacc cccactccct aggcaaagat 117360 cgcaggaggc cccaggcctg ggattcgccc tgccctcgcc cacgattagt tactgaaggg 117420 ctgcggttcc ttcgtgctca ttttccctct aagccagggg ctgttcccag gcctccctag 117480 gctgctttga gaactgaggg agcaggtggc ggggaccccc caagctctcc cagagttgga 117540 ggccggcccg cttgaatgca agctgcgtgt ctgagcagcg tgctctgccc tgccctctgc 117600 cctgggctgt agcaggtcct gagtgtccag gccaagcgca gttcccagac cccatctggg 117660 gtgtgagggg gtgtcaggta ggcgctagca tctgatgctg tccctttctc aatgtcatca 117720 ccaggagccc gaaggcgcag aggccagtgg catgccccaa aggagactcc ggagagtcct 117780 caggtgaggg ccagccccca caggaccaca gcccaggccc caggacagcc ccaaggccag 117840 gctcccagga gcaggcgggc aaggactggc agtagggtgg aactgggcac catgaagaca 117900 agaaggccac cggccacccc gttctggcct caggacactg accacccctg ggggtggtct 117960 agggacttag gggaacctca tctcagccgc aggtggagca cccagtcccc aaagacaggc 118020 tgaccgcacc accccagggg gacgccgcag cacagcccag caccaggtgg ggcagaggtg 118080 accacggccc ctctttgctc cgtcatcggc tggtcagctg tggtcacggt gcctcagagg 118140 acagatctct atgggggcaa gtgccagatc ctgagagcgc atgagacgct ttcccggagc 118200 cgacgaaggg gactcggagc tgcagcctgc acgacccctg cagcctgtgc tttgcccacc 118260 cctttcaata gatggaactt gcttgctctt ttttattctt ctcaggattc attttttatt 118320 tcacatattt gtttgtttgt ttatttattt ccattgatct ctttaccctg aggtttactt 118380 gcaaaatcag ggttcatttt taaagcaggt cctcagcccc agccacactg aaccacctct 118440 gccctgacac gggaggggtc ctagctgggg tagctgggct ttagcacctg ctcactgcct 118500 gccatgaccc ctgaccccag tcctggccat cctccagcct gtcccaggaa gagggagcag 118560 agagcctcat ctcagcctgg agggggccga ggacgggggc agcacacggg cagtctgggc 118620 tgtggggcag gaggccagac agggtggcac tggtgcctga ggggttgggt gccaggctct 118680 gtgcccggcg ggggctagga tcgggggtgg caccgtcccc acaggctctg aaagttgatc 118740 actgtcctct gtccttgcct gccttgcccc agaggcacag cctcaaaact gtctccactg 118800 tgggaaagca gccctaggcc cctgtctggc cacttcatct tctcttggtg tgggctagag 118860 gcgccagctg aggagtgggg gcaaagggga tggcccacct gcagcccagc cccagcccct 118920 gggcaccttg caagcacccc ccagcccttg acatgccggc tggcctccag atcccaggcc 118980 ccctgaggat gctggaatct gccacagagc atgaagaagt ccctggaatc ctttcttgcc 119040 attcacctga cctctacaag aaggggccgg tgatcatgat ttgacagctt gggacaagaa 119100 tccagggagg ccgggtctct ggcgcgcctc catgcccctt caagaaggtg ctatcctggt 119160 gttcctgagg agcagggcga gcctgggcct gagggaacag gtacacaggc agcagcactc 119220 agggccgggg agtgctggcc ccacccgcct gcgctcactc gaaagctgct ttggagggct 119280 gggctgcagg ggcagaggct ctggaaaaga ggcccaggct gtgtagctgc ccttccttga 119340 tggagcagac tctattctag aaatttctat aagaagtaga ctcactccag gacaagtggg 119400 gctgggggga gcggatgccg aggggctctg cgggcacctt gtgcctaaag tcacgggggg 119460 cacaggagag agcgggaact aggtggactg ttgtggctgc catccatcgg caacgctggc 119520 cggaaccaga tgagcagtgt ggggcgagag ggagccccag tgcggcccct caggccctcc 119580 atgcttcagg gtgtcagtgg ccccggactg gcctcactca gccctgggca cttgggcctg 119640 tcggggatct agctttcagt gaggacccca ccggtggact gaggctcccc tcaccgtggc 119700 agaggaatct ctgcccttcc caccgaaagg ggcaggagct agtggatggg gacggctcac 119760 ggccctccct ttccacttgc cttggaaagg gagaggcagc agacaggaag ggccttggaa 119820 ctcaggccag tgtggggaga gtgtccccag agagtccttg gggtgggaga ggggtggagt 119880 tgacagccgg tgaggccggc tttgaggttg tgtggaccct gtctgcctct agctcaagtt 119940 gggaggggtg tcagctgtgg agctgtgtga gcctcgggga cagccacatg tggggtgcag 120000 accggtctag atgtgcctgt ctggtgggcg ctgaaggtcc ccttgggaga gtccagggca 120060 gcacctgata agccgagagc tgcagccgtg tccacctgga acctgtttcc tcaccgggaa 120120 catgaacacc tgcttcagaa gctttggggg ttaaaggtgg ggatacacat aggtctcttg 120180 cccagcggtg gacactcggt acactcctaa taaatggggc atggggtggt ggagtccagc 120240 acctggctgg gcccaggaat gaggcatcag tggtcggagg gaagggcgtc tgcccaccta 120300 gcatctttgg caaggatctg cctcccagca cccctgtgga gtcctgtctg gatgggaggg 120360 agagcagggc cgtggacagc ctccagaggt gttcccctga aacctctgaa tgtcaccagc 120420 acaagcaggc tgggctgggc tctcccggca gtaacaccaa ccgagcacag ccgttgtcct 120480 ggggcatgcc gtccaggttg ggggacaggg aggcagaggt cccgtgtcat tgcccgtgag 120540 tccggggctt aggcaccgct ctggggaccc ctcatgctgg cccccaggcc cactgaggca 120600 taggtgagac cattgcatgg tccttggaag aacagggctc ctcaggcagg gagtggacag 120660 agccaatgct ggcgatgggg gaccttgcct caagcagagt cgtgggagat ggagtcatgg 120720 gggcgtgtgg gggtctaggc aggggagctg ctgactgcag gtgrcccagc agtacccagg 120780 tttctgctcg ctcccattcc acctccccga gggcactcgt gggaaaggga aacatggcac 120840 ccagctggtg cctcattcca cctacctcct gagtcaaagg gctccaccac cccagacaca 120900 cccagagcct ggtgtccagg atgccatgtg tgtgccccaa gccagtagga cccttgggag 120960 gctcagcacc ccctgcccca aacaaatgcc tctcccctct ccacactcac tggcattccc 121020 acagaatgcc ctcctgactt ctagagcttt ccctgtccag agctccggga gcacaggtgg 121080 cagggaatta gaggcattag aagcacagtg tggaagctgg gcagagctgg ctgagatccc 121140 actgtctctt ccaggctggc cttgagcaaa gctcaaaacg catcccacag gggtcagtac 121200 ctgcccatgt ggtgggggat attccaccag gtgaagtgtg taagggctca gcagggagcc 121260 ttggcacatg gtgagtcctt ggtgagggaa ggctgttggt ttggagaggt gaggcccaca 121320 aggccgtcag tccgccatgc tgtgccaacc ccagtgatga gaggatgaag ccaggtcagg 121380 gaggtctcat ctaccaggct cccacctgag ctggcagctc ctcacgccat cccaagccat 121440 cagaactcag gtcctcgaag ggaggcctgg ctgccccctt cctctggagc cagacaggac 121500 cacacctcct gcgccctggg gcttcactcc aacaggggag cttcccaggg ggccgggaga 121560 ctcagaagaa atgcccacaa ctgcctggca tgtggtaggc tttgcacaaa gagcagtagc 121620 ttcaacccca atgacccacc tctgtgaggg gggcagagat ggctctgggc tcctctgggg 121680 ctggaggtca ggctctgctt aaaaccgttg gttcctcaag gaccatgggt gtcaggtggg 121740 cctccccagc tgagggcctg gccaggacct ggtcaggggg tccttcattt tcccctcccc 121800 ttgcaagaag gagcaggcca gagcctggag ataagtttgc agacaatttt tacgtgagta 121860 gtttatgttt gttttgagat aaaagtcatc atttccacta caactcattg acttttggta 121920 tattcacaat catgtgcaac catcattact gtttagttcc agaacggttt tttaccccaa 121980 agggaaaccc catatccatt agtagtcact ccccgttctc ccttccccag accctggcac 122040 ccagcaaggg cttcctgtct ctggacaggc ctgttgtggg caccatgccg acgtggaatc 122100 accgtgtgtc tctggacagg cctgctgtgg gcgccatgca ggcgtggaat caccgtgtag 122160 tcttttctgt ctggcttcct tctcttggca taatgttttc aagatgcacc tgtgtcgtgc 122220 caggtgtcag gacctcattc ttctttatgg ctgagtcata ttccatcata tggatcagta 122280 taaacatttt gttaatcctg gtggatattt gggttttttc cattcagggc ttttgtgaat 122340 aatgctgcaa tgaagactga tgtacacgct tttgtgtaaa catgttttca gttgccttgg 122400 gtatatatac ctaggagtag aatttctggg tcatgtggtg accctgtgtt taactttctg 122460 agaaactgcc agacttttcc atagcagcta catcagttca catccccacc agcaatgccc 122520 aagggttcca ggttctgcac accctcacca ccacttgcta ttatctgccg cttagattct 122580 agccattcct tggagtagaa actggtgttt cggctgggca cagtgagtgg ttcatgcctg 122640 taatcccagc actttggaag gctgtgacag gaggatcact tgagcccagg agtttgagac 122700 cagcctgggc aacatagtga gacctcatct ctacagaaaa ctaaaaaatt aaccaggcat 122760 ggtgatgcac tcctataatc acagctactc gggaggttga ggtgggagga tcacttaagc 122820 ccaggaggtt gaggttgcag tgaaccgtga ttgtgccact gcattccagc ctgggtgaca 122880 atgagaccct gcctcaaaaa aaaagtggta tttcattgtg catttgattt gcatttcctg 122940 atggctaatg gtggtgagcg ccttctcatg tctagtaacc atttgtatat cctcgtgagc 123000 aaagcatcta ttcaaatcct ttgcccattt taaaaattgg gttgtcatct tgttgagttg 123060 cagaagttct ttatatgttc tgaatcctag atattgatca cttctttagt ttacaaatat 123120 tttttcctgt gggttgtcat tattttcttg ttagtgtcct ttgatgcatg aaagttttta 123180 aatttgatga agtccatcta ttttgttgct tatgcttttg atgttagatt taagaagcca 123240 ttgactaatt caaggccatg aaaatttaca cctacatttc cttctaagaa atgtatagtt 123300 ttagtgcttc ttacctttaa gtctttgatc cattttgact taaatttgtg tatggtgtaa 123360 gggagcaggt cccatgtcat acctgtgagt agccagttgt cccagaccat tttgctttgt 123420 tgttgagaca gggtctcgct ctgttgccaa gactggagtg caggggtgtg atcatggctc 123480 actgcagcct cgacctcttg ggctcaagca atcctcctgg ctcagcctcc agagtagctg 123540 ggactacaag catgtgccac catgcctggc taattttttt ttttgagaca gagtctcgct 123600 gtgtcgccca ggctggtgtg cggtggcgtg atctcggctc actgcaagct ccgcctcccg 123660 ggttcacgcc attctcctgc ctcagcctcc tgagtagctg ggactacagg cgcccgccac 123720 cacgcccagc taattttttt ttttttttca gtagagacgg ggtttcaccg tgttagccag 123780 gatggtctcg atctcctgac ctcgtgatcc acctgcctca gcctcccaaa gtgctgggat 123840 tacaggcgtg agccattgtg tccggcctag tttttcaaga tttttttgta aagacagggt 123900 ctcaccatgt tacccaggct ggtctccaac tcctgggctc aagctttcct cccacctcgg 123960 cctccccaag tgctgagatt acaggcgcga gccactgcac ctggcccatt tccacttcct 124020 cctttccact ctgaacgcct tttatttctt tttcttgcct cattgctctg gctggaacgt 124080 ctagcacttt gttgaacgtg gtggtgagag cacacgtcct cgtctcattc ctgatcgaac 124140 gcggtggtga gagcacacgt cctcgtctcg ttcctgatcg aacgcggtgg tgagagcaca 124200 catcctcgtc tcgttcctga tcgaacgcgg tggtgagagc acacgtcctc gtctcgttcc 124260 tgatcgaacg tggtggtgag agcacacgtc cttgtcttgt tcctgatctt aagggaacgt 124320 ttgcagtctt tcaccactag atgtgatgtg agctgttaga ttttcaagga tgctcttcat 124380 ccagctgaag acggtccctt ctagtcctaa tttgttaagt gtttttatcc ttaaagggta 124440 ctggattttg tcaaatgctt ttctggcctc tattgaaaag atcctgtgtt cttctgtgaa 124500 tatgaggtgt tacattgatt gattttcata tgttgagcca gtttccattt gtggaataca 124560 tctaactcgg tcatggtgta taatccattt actctgctgc tgaatgtgat ttgcttgtat 124620 tttggtgcgg atttttacat ctgtatttat aagggatatt ggtctggtgt ttttttatga 124680 tgtcttcctt tggttttgat atcaggataa tattagcctc atagattggg ttaggaaatg 124740 ttctctcctc cgtttttttt ggaagagaga gattggtgtt aattcttgct agaacctttg 124800 gtagaatttg ccagtaagcc tatctggtct tgggtctttg ggaggatttt gattcgattc 124860 aatctatgta tttgttatag atcgttcgga ttgtccatcc ttgagtcagt tgctagcttg 124920 tgtgtttctt ggagtttttc cgtttcgtcc atgttatctc atctgttggc ataccgtcgt 124980 tcacgggatt ttattgatgt gtgtgaggtc tctgagaacg tccctgcctt cactcctgct 125040 tttagtcact ggcatcttct tttaacttgg gccatctggc cgtgcatggt tttgggagag 125100 tcctccttga ctctgcagat gctgagcagt gatctggctg ggaaagggga ccaggagtgc 125160 agggcacctg ctgaggactc acctaagccc aagagtcaga gagtcggagc tccaaccaca 125220 tctgcctgca tgcctttccc aggctctccc caggcggaca gccagcaccc cctccccaaa 125280 gaccgggcag ttcctgacca gcaccccacc aagtcctcag taaggcctgt ctttggggga 125340 gcagggtttc aggaggacag tgggggtggt gtagaactca tggctggcgg ttccgggcct 125400 ctcaggaagc tttgccactg ggcttggggt taagtgggtg tggggctccg aaccctaaat 125460 gggtgagagt tgaaatgaaa gcggcacctg tagtccgttt ggggtgcagg tgtgtgccag 125520 gggtcttcag ccccggctga tggccacatg aaccacatga ggagaggcag ggcgtgtcag 125580 cagcaaacct aagtgtgtgc tcatttctgt gggcccttac tctgtgacac tgcagctctc 125640 cagagagacg ctttgaaaac aaaacaggaa agaacacacg gccccgcgtc tgttgcctga 125700 gtcactgtat tccttaaaag gtgaaggacc ctggtccttg gcttttcgtg cacatgagaa 125760 aatgttggcc aaggttagcg attatgcttc tgtaatctgt aaccagaagt gctcttatgc 125820 ccaaaccttg atgtgattct gctgtaatgt aacttcggag ccagctggat ggatgtgact 125880 gtgcaggtcc tgagccccgg cccccgtaac caagcagtgg gccgagacac tgagccgggc 125940 agtcaaacag gagctctcta aggctgctcc cgggctggga cctgggtcta ggattctcag 126000 taagaccttt gaataaaact aacttgaatt cttcaaaagc ttgatttttt ttcttcagtc 126060 aaaagcatct tgcagagatg ccagcccacc gtggggatgt gcagtggcag ccctgagctg 126120 gcccagcccc tttccccaag gctgctctgg ggaggggggc gggtttgggg gagtagagtg 126180 caggggattg aagcagggga aacagggtgt gagggtcaag gggggctaga attgggggag 126240 caggttcacg ggccaggggc tgggcagggg tgggcctggg cacctggtag gtgggggagc 126300 cccaacttcc catccctgcg tcacacgccc ttcccctgca gggtgggggt ctgcagggtt 126360 ggcatgtgcc cccctgccct gtccccaccc tactccccgg cggcaggcag aggggcgtgc 126420 aggggggccc taagtgcagt gacgtctcga ctctgactcc gacccacaga actttaaaaa 126480 tagggccgtg gtaaagtccg tctctacaga ccacagcctg cccagagcta agaatattct 126540 tgaaccactt aataattcaa gtcagatcca aatagatttt cctgctcact tgcgggcctc 126600 tgtgtccctt tcccaggccc ccaccctgcc tggaggctgg gagggaaaga ctccaagaag 126660 caggtgggcc tggcctttgg agcctctgag accccagctg tcctgcgtcc cctctcctgt 126720 ggcactcagg atcagaagac acaccagggc tggagtggtc ctttaggatc tggccaaggt 126780 caggccccag ggaggggccc ctctggtggt cctagctgtc ccaagcccca cccctgctct 126840 ggccacaggc attggactat ttgaatctgg gtctgagctg ggccttggcc ccttgcacag 126900 catctgacct gagccacgca cctctcatgg gggccccgtc ctccagggcc aagggcagca 126960 tgagctccag gagagccagc ctcgcccctc acaccctggt agctggtaca cgcccacccc 127020 agggcctgtg tcctgcctcc tctgcggaag agtccctgaa gggcctggcc tggggctcct 127080 tgtcctggtg gaagtggctg tgcacaggca accagggccc tgggttccag accaaggcct 127140 ctgtacttgt gtgctgtgtg tgcttgggta agccacctcg cctctctgag cctcttatca 127200 gtgggaccga tgcttttaga ataagctgtg gtgtttgggg caggaagggg tatctgacgg 127260 gtgccctgag gcctgagtca ccctctcctc caggggcagt gcccaagctg cagacacccc 127320 tcacccatcc ctgtctcccc ccaggctctg gtctttcaaa caggaactca gggtgaaggg 127380 gtgccacctg ggaatgtttg ggggagccca cacttgctgg cggggaagtg ctcaccagcc 127440 tggcccccca accccggcag cagcccagcc ttagcagtcc ctgctgaact tccctggcca 127500 ggccccgagt ggagttttac caaattatta attaagggca aagccatgct gcagcgctga 127560 catccagatg aatagcacgc agtgtaatta ggcgaggtgt catggagatg atggagtaca 127620 gcctgctagc cccaattcac ctccccggca agcaggagca acttctctgt gtcctaccac 127680 catgggcggc tggtgtgggg ccagtagggg tgtggctaaa ggggccagct gacagctatt 127740 gcgggtgcca cgggccctgt ggacagggct gggctcctcc cccagggaca ggcacccctt 127800 cccctctgat tgccatgggc agaacccaaa agggagtaaa gtgcagaaag gggcaggcaa 127860 ggtgggaggc aggctaaggc aggagggatg aggaccagga caaatccaca gatagacccg 127920 gagcagccca gagaggggca tggagggagc acaggagggc cgagaggggc cggggaggag 127980 gtgcagaatc caggaagaca ggacaggcct cggggcccta ccctggggtt gcctgggcct 128040 gacagagagc tgggagcggg gagcagcttg agaatttttg gttttgtttt ttagttactt 128100 acattcatgt atttttggtt gtttgagacg gagtctcgct ctatcgctga ggttggagtg 128160 caatggagca atcttggctc actgcaacgt ctgtctcccg ggttcgagca attctcctgc 128220 ctcagcctcc tgagtagctg ggattacagg cgcccgccac cacacccagc caatttttgt 128280 atttttagta gagacggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc 128340 aatgatccac ccgcctcagc ctcccaaagt gctgggatta cagacataag ccaccgctcc 128400 ctgcctacat ttcatgtatg cttttaatca acatcataaa ttgacagttt taataatcga 128460 atagtactac aaggcttctg acgaaaaacc acacctcttt cctgattccc ccttctcaga 128520 ggcaaccttt tctgtgattg tagctgattc tctttggtat ttacttccga atagccatgc 128580 tcatgttgct gctggtgctg cttttttttt tctccttttc agattgagaa atttacccat 128640 gtccttccca cgatggcggc tgaaagcttg ttctctcaca cgtgcccccc cacactctcc 128700 caccagcttc tccttttgat tgaatcagaa ttcaatgtat gcactattat ttctcagcac 128760 acactcttcc cagctgagta atgtattgta attacatttc ctttcttgta caaccactta 128820 tttttcctgg acttaataat tgcctcattt aggggattgg gttgatattc tgtgtaccca 128880 ttacttattt atccccaaac cctgccatgg aagtataaat ctccttttgg ttcattaaaa 128940 acatccggcc catctgggca cagtggctca cgcctgtaat cccaacagtt tgggaggccg 129000 aggcgggaga attgcttgag cccagtagtt cgagaccaac ttgacaacat agcgaaaccc 129060 catctccatc actatttagt tttaaataaa agatattttt aaaattaaaa acatccaggc 129120 caggctgcgc tgggcccgcc tcactgtagg gggctgcgct gggcccgcct cactgtcggg 129180 ggctgcgctg ggcctgcctc actgcacggg aagtgtgctg ccgctgtcct tggtgctgaa 129240 gtcaaggctg gggccggagc ctctcctcca gcctcactcc tcttcagctt ccgccctgct 129300 tcgcctccat tcctgcccaa gaccccctgg ggagcagacc ccaggccctc ctcaagactg 129360 ccgaccccag ccctcgtccc agcccaggcc atctctccca ggccttgcct ttctgtacca 129420 ggtggtcttc ctccccaggg ggctcctccc cgcagccctg gcagacagct tgaatcctgg 129480 agttgcagca ggtgggtgtc tgagtggagc tcccttgtgt ataatcagaa ctctccaggt 129540 tacatgtgac aaaaaccaac ttaagcaaag ctgggacctc gttagttcac tccaggaggc 129600 agcgccgccc tgcatggcct ggccttggct ccctccctct ccgggaggct gctccctcat 129660 cagcccagcc tcacttcctc acccacataa caatccttgg cagagtgagc cctgctgttc 129720 cagcggcccc agtggcccca gcgaaggccc cacgccgaca cttgttggct ggccaggctt 129780 gagtcacatg ccttcccctg aacccctcac tgtggcctgg ggtcgggggg ccaagtgccc 129840 agtgcagagc tagggcctgg agcagcctca gtgcaccttg tggagagggg gacttctcag 129900 tagaacagca ctcttgccag gagaaggaac acctggttga gaaaaccgag gtcaggtgac 129960 cttctcaaga agggtcagtg gcttcaggat ctctcataaa gcttcatctc caaggcccaa 130020 ggagagcaac agtgtcccat cttgtctcca ggtaattcta ttccggtgcc agcagagaac 130080 agcgtgatta agcctccatt attaacttgc caatcttgtt tctggggcac agacgctaac 130140 ggcttagggg acccagttgg catataatga ggtctccatg acaaattact tggttatcaa 130200 ttaactatct ggggaaatgt caagcaggat ccatcatgct ggcaggaaga gagagccaat 130260 taacccaggg cagttcatcc aacccaccgt cgctgcgtcc agcagggcca ggaatgagag 130320 aaagggcctg tggagcccag agcagggcag ttcctccacc cccccaggga cggtgtgaca 130380 ccggctgcgg ctacactggt ggcagcttct gcagtcatgc ctcgcgtgct cggcgcacca 130440 ctcttgcctg tacctgtctc tgtccattca ttcattcatt ccacagtcac ctgcatgtca 130500 gacctggacc aggcacggat gggagaggtg actgagggct gaggttaggg agggacacac 130560 gtgcagactg cagacaggtg tccctgtctt gtgtggtctc tgcagtcagc aagatgggta 130620 acagcatcct caggacaggg aggaaagaag agttcattct aaaggtggtg gggggacaga 130680 gagagcatca tagctgggag gagagaagag ttcattttaa gggggtgggc gggggacagc 130740 atcacagagc tgggagaaga gttcattcta agggggtaac ggggggacaa agcatcacag 130800 agctgggagg aggagagaag agtttgttct aaaagtgggg ggcacagaac atcatagagc 130860 tgggaggaga gaagaattca ttttaaggcg gtaaggaggg gacagcatca cagagctggg 130920 agaagagttc attttaagag agggtgacag agtgtctcag agccaggagg aggagagaag 130980 agttcattct aaggtggggg acagagcatc acagagctgg gagaagagtt cattctaagg 131040 ggcgggggac agagagacac agagagactc tgtgacagca tcacagagct gggaggagga 131100 gagaagagtt cattctaagt gggggttggg gggtgggggc aggacagagt gcatcacgga 131160 gctgggaggt ggaggaggag aagccaggtc cctgagacaa ggggcagggt gggtggccac 131220 caggcagagg gtgcccaggc acagcagggg acggggctgc tccaggcttg ggcaagggac 131280 cattgactgt gcactgtccg gacctgagca gaatctggct ctgccgtcgc tgtgctggga 131340 gaccttgaaa cagtttagta aaacctcgcc gggcctctgt tttcttatct ataaaatggg 131400 gataataacc cccagttctg ggagtgttgt gggaactaac actgtggccc ccacttggtg 131460 ctggctgaac ctggttcctc cttctcctcc ctacaagaga ggccttggac ccacctcact 131520 ggtgaaggct cccagggtgc acatgccgga gcagaggcgc agggaggagg gaggcatcct 131580 ggaggaggtg gcttgggctg tcctggagga gggaggtggc ttgggctgac ggccggcaca 131640 cggacgggcc cgaggccgag tggcagggtc ggggactttg gtcacttatc aaagtcaaag 131700 cccaggactt tttgggtttt gctttgtttt cagcaaaggc ccttgggtca cctgcgatgt 131760 gtcccaccct tgtgagaacc agtgacgaag ccctggccct accctgtccc ctggcctttg 131820 cctgtgcccc caccccgccc ctctggtagc cccctcccct tgcctacttg ggggtgattg 131880 gcagctgcct cttcccagcc ccccaggcca tggcacggag cctcaagcct attcatgatg 131940 cggacatatg gcacctccac ggggggcttg gaggaaactg ccaattgcga gagtgcagcg 132000 tgtccccatt ccagccctgc cggagcaaaa caaacgcaag tcgcgagggg agcagaggcg 132060 gcccgggggc gtgcgcatgt gtgcgggtgt gcctgtgtgt ctgcagctca caccgcgggg 132120 gtgccgggag gaggggggct gcccgatcct tgggagtctg cggctttcag acgctcctgg 132180 gggctcggct actggggtcc taaggaggcg agctggcccc ctcattccgc cccgcaggcc 132240 gtgcctctcc tgtcttgagg ccgcttttgc ctccccacac ctcttaccca ggacgctggg 132300 ctggaggctg tgaacagccc tgggagcaga tcccagagat gctctcattc tttccggaat 132360 caggacgttc cccccagtgt caagcccaag tccccagggc tccaggctta gccaaactct 132420 tctgttttat tggaggtggc accaccccca tatcagtggg ggcactgcag ccaccagtgc 132480 atggccccct aggcccctgc cccatgctgg gctcaccctc ctgtgcccag ctggggaccc 132540 aggcatgaca aagccctgct cctgcggcag gggagggcgt gggggggtgg gggggcgtgg 132600 ggagggagtg gggagggctg caggggaggg cgtggggagg gcgtggggag aggctggcca 132660 aaggccaggc tctgggggtc tcagcacact cctctcccga cccagggctg gaggctgctg 132720 ccatggaaac caggcctgtc cacccactgg ccatgtgcat ccaggggcca tggccaccac 132780 ctcctagcac ccagctctgc cccccacccc cattcggggg agtgagaagt caggagagag 132840 aggaagggcg ctaagcagaa cctggagggt gggcctgggg taccagaggc tgaggtgctc 132900 aggcaggcta agggtaaggg gcctgtcccc tgagccccag ctgagggtct aaccctctgt 132960 gctgctggga agctccagac cctctgccac aaaccttggc atgcacttcg ggcagtggca 133020 gcccctgtgg ggtgtgtccg tggcacccat cagcctcctc cttgtggctg gggcctagga 133080 gcagaatctg cacgctttgg gccttcccca gggagtcagg gaggcgaggg tgcagcccgc 133140 tagagagtgg cccatccatc agttccctcc caggagcgct ggctggggat gctggtgggg 133200 aggggctgca ggggcggctc tgactccagc tctgccgaca ccctgtcccc agcactggca 133260 ggcacctggg tgtcctaatc tgtctatagc ctggccttgg acgaggggcc tctgccccag 133320 ctgggtgggt gtttcagggc ccaggccccc accttggctg gcagcgtgca cacccgccac 133380 aggcactggg ccgaccaagt tgcaggcacc actgtgcatc caagcatctg ctgccgccgt 133440 ctcggggcag atgggctgcc agtgagctaa gtgtgtgcgg gggaaggggt gccataggaa 133500 cccctccccg ccgggagcgc gggggcggga gaggcaggca cccgccggtg ggggagccgg 133560 gagccatcag agggaggggg gctgggatca catgggctcc agggttgggg agaggcccat 133620 gcagcccgtt cctgggccag gggctcaggg gatctgggct cagcctcgga ggatgcagag 133680 ccttagaggt cctgatcagg gctgggagac ctgtcacccc tggccaggtg gccctgggca 133740 agtcccttcc ttctgcaggc ctcgggcccc aggagtgtgt gtggatggtc tagagggtgc 133800 cttcccgctc cggagccctg tgccttggca ggatgaaggc gtcctccgca cacagatgcc 133860 tgccatctgc aggggcctcc tgccagggga caccagcaca ccctgccaga ctgatccggg 133920 gcacgtgggc tacacctccg ccccttgctc caaggctgtg gctcccagaa aggctggggc 133980 catgctgtgt gttaagtgag gccacttcgg agtttgccag ctttccccag tccctgcctg 134040 gccacagcag gagccccacg gtgaggggac ctgccaggct gggcaggatg ctggccaggg 134100 tagaagatcc tgccctgccc ctgctgcccc ccaagcccat cacactgtat ccaagacccc 134160 tcaggagtac tgggatccga ggaaggaggg agtgtgggag agttggcaag gagacagccc 134220 aaggccacca acagccttgg aagccgattt gttggggcat caggagggcc ttgagcagag 134280 aagacgaccc cacggacaaa ccctgcagca tccctgctcc aggagagggg tgcccacccg 134340 gcctcagggg gcttttcttt catgatggca gtaaacagag caaagttgtc tgtgctcagt 134400 ccctgtcctg tgccagaggc tgctctgaga actcagctct tctgtaattg gcacaagaat 134460 gctaagagcc acccttatgc ccactagaca gaaaaggaga ctgaggctga gcaagctggg 134520 gcagctggcc ccggccaggg gccaacgaat ggctgagctg gaatttgagc ctgaagtctg 134580 cttgacccct tgggctttct gaccagagca ccccactgga agggcacgtg tcctccagga 134640 gaggctgcct ggtgcctcca aaagtgcagg gaaatggggc aggtggcccc tctgtgcccc 134700 ctcccccacc aagcctaagg gggcccccat cgccaccatg gctctctcgg attcaacaga 134760 tgcctccgcc tggctgtgac tcagcctctt agtttgttgg tggttgcctt tttttttttc 134820 tttttctttt ccaaagtatg acatcgccac tgagccttgg cagagtggct cccaggacac 134880 tggcaggtcc ctcccaggcc ttgctcagga gtgcccatgg gtggccccag cttgcagggg 134940 ccaaggtggc tgatgaccag atgccatgac aggcacccca aaagggcctc gcccttggac 135000 tgtggccctg ggcagactct gttaccttca aagtaggcac agcccatccc ttagttgcac 135060 ctgactgggg cacagtgccg gggacacctg tccaaagtca ccctccccag ctgcctcaca 135120 gcccaaggac atctgtccaa agtcaccctc cccagctgcc tcacagccca aggacatctg 135180 tccaaagtca ccctccccag ctgcctcaca acccaaggac acggcgcgta cttgacgttg 135240 cagattgggc cagaaaccct cctgggggga ggggcccaga gccctacttt tcacgggtgg 135300 gctaagaaac agaggatgtg tcttggagaa gacttgcagg ccaggagcac tgcccattgc 135360 caaggccagt gggctgagtt ccacggagag aaaaaggctt tccctccatg aaggaagctt 135420 tcttggcatt tgggactatt ggtagagccc acagtttttt ttgttttttt ggttggtttg 135480 ttttgtttta tttttattat tttttttttt tttgagatgg ggtctcactc tgtcacccag 135540 ggtggagtgc agtggtgcaa tttcgcctcg tggcagcctc gacctcctgg actcaagcaa 135600 tcctcctgcc tcagcctccc aagtagctgt aactacaggt gtgtgccagc acacccagct 135660 agtgtgtgtg tgtatacaca cacacacata tatagtagag acagcatctt gagatgttgc 135720 tcaggctggt ctcaaactcc tggcctcaaa cagtcctccc accttggcct cccaaagtgt 135780 tgggattaca ggcatgagcc accgtgcctg gccttagcct gtgttttgtg aggtggtgag 135840 ttccctgtcc ccagaaggat ttcagcaggg atagcattcc tcacgggact gagtccctgt 135900 ggtgcaatca gagaaaagag tcactcacag ctggagttgg tcatttcagg ttcaagtcca 135960 ggcgtgtctg tgtgaactca ggagcagggt attaaacctc tctcctcatc tctgaaatgg 136020 gatttgggtc tccctcaaag gcagttctga ggtcaccctc aaaggcagtt ctgaggtctc 136080 cctcaaaggc gagactgtgt gcagaatgtg tgcagacatt ttcatgcccc agtctgactc 136140 atggccctgt gcatcttgac aggtctctgt ctctgggagc ctcatcagaa gaaatggctt 136200 aaactccaca gggcgggatt tggggaggag aaagagcttt gggctatggg gagtcaggag 136260 acgaggggat ggcggggctt actgtccttt cagtgacccg agaaagaggc tggcttgggt 136320 gagaggaatg gggcagcttc tcttgcctct gggactcagg agaacccagg gctctgaggc 136380 ttggaggggg tctggaagct gttggggggc aggtggggcg ctcatggcat gtagaactgg 136440 gacatgccag gcaacagtga ggaggccaag ggtggtggga aacaccatct ggcagtggca 136500 agcaggtctg ggcgtaagag gacagacaat cccacgtcca ggacgacagt cccaaggcag 136560 ttggctcctc ctgccccagc ggtcccagcc gacacccacg tccttccctc ttctcctcct 136620 ccctccccgg ctgcccgtcc tgtgcccatt tatcatgccc atggtagtgc cccgaatggt 136680 ggtcccaggt gtccacccac aacctcagaa tgtgaccttt tttggaatta gtctttgcag 136740 atggaataaa gttaaagatt tcgagataaa atcatcctgc atgaagggtt aacctgaaat 136800 ccaatgacag gtgtcctcga aagagaaagg cagagggaga tttgagaccc agacacccac 136860 aggggaaggt agaggtggga cagtgggaga gatgcatcca caggccaagg agtgccgagg 136920 tccccagcac ccacggaagc tgggaaagcg gcctgggaca gggtccccgc agaggaccag 136980 aaggattttg gaattctggt ctccaaacct gttagagaat aaatgtcggt tgatttcagc 137040 catcaagttg atgctcattt gttaatggca gcccccagag agggagacag cctcccttcc 137100 cgtctctcca gcccagcaga ctgctgggta ttggggttgg aaaagtcttt caagggctca 137160 gggagtgctg gggtggccac caccttctga gcaccatcct gtgcctgggc ctgcctccct 137220 tgcagcccga gcccaggcat aggagccagc tccactcgca cctgccagcc tcagcctcag 137280 cctcagaggt gagcaatgcc aggaagccga tgcctccaga atcccttgac caacggggac 137340 ggcagcgggg ccctggcttt cagaacagca ggtgcgggct gctgggtcca tgcccggtgg 137400 gggaggctgc acggttgggc ccttgttctt ggctgtgtgg ccgccgaggc tctccggaag 137460 gttctatgag cctcctaata tcttgtattg ggttccatta agctggccag agtgggttct 137520 gccggttcca agtggtgtgt gggatgggga agtgctctca gctctgtccc tgggacaggt 137580 ggggggtggg cgcgtcacat gccagagatc tggggtgaag gcctgaagac ccttcccctc 137640 ctgctggagg agagccgacc tcccccacag ggcctcgtgg gagtacaggc ggccagcagg 137700 cccgtgggag atcaggaggg agatgtgttc atagccggca ctcgaggcac ctgggttcgg 137760 gacacacctg ggctcgggtc acagaagccc cccattcccc aggttgaaga ggcctgggct 137820 ttccctgggc ctggctctcg ctctcctccc ccaacgctgc tctggtcccc ggcggcctcc 137880 tcagggccca agtcctccct ccccctgtcc tccttctctc cactaccccc ttcttagaaa 137940 tgaagtcatc tagaaaaata atcaaaaaat agaaaggaaa aaaacacctt agaaaatggg 138000 attttttttc cccttcaaac atttggtgag acacctccca cacggatgag tggccacggg 138060 gcctgttttg gtgtgagaga gacttgggcc tgtacccttg gagttgtgag aggcaggggg 138120 gcctcccagt cccacagtgg gggtctacac taggcctccc ctctgcagcc tggccaaggt 138180 tggccccaga agcctgaggt ccccgccgat gccctgagca ggaaggccgc tgagtccccg 138240 aggccagggt gcaaggcagg gtgggagggc tggcgggggc caggccaggg gctgcttagc 138300 acctaagtga ggccctgcct ccggtctctc ccctcttccc acccggccca cgccgctgca 138360 gggctctggt ttgtttattt ataattcatc ctctgcctgc ttccaagaag gctcccggca 138420 cttactggaa agctgcttcc tgaagctccg ttgtgctcct ggcaggctcg ggctcaaagc 138480 ccgtcaacgc ttccccatca ctcgcaaagg cagacgactc agcctggctt ccagggccct 138540 ccagatctgg cccccaaatg cagtctttcc gccacttcct gatgtatctc ctggccccag 138600 agggaccctc ccttacaatg cagattgctc gagggacccc gggacccagg atacttcctc 138660 ctaccttggg atcagaccct ccctcatccc atggcgcctt ctctggtccc gacagtgggg 138720 gacgttgaca cctctcttct gcccattggc tgtctgctgt cacagttacc tggtacaggc 138780 tgctccttct ggccccagcc cgacctcccc ggcccttgga ggagcttaac caagtcaaac 138840 tattgttaag gttgatggtg acaatgccag ggaaggtgga ggctcccctc tgcctccgga 138900 gtggcattga agacggaggt gcctgcagtt ggtccccacg ctcgataggc aggaagcttt 138960 ggtcaggagt ggggctgaga ggagccaccc tggtggctta gtctggacgc ctgactgggg 139020 gttccatgag tgtgtcctcg ggggctgggt ggcgaagtgt gactccacgg gctggaaggg 139080 cggggacaca gtgtggtgag aaacagcatg cagggctgca ggcggcagct ctgcagtcag 139140 ggctctgggc tcagggagct gtcccctgag cagggaagct cacaccagaa ttggtcaggc 139200 aacccaggga tctgtgaggg ataagagatg gtagttgtgt gaagcctcta ggctttgggg 139260 tgatttgtta cacagccaaa gctaactgat acagccagga actgctgatg gcacagccgg 139320 aagtcccacc cacccttgag agatcagccc ctgccttggg caggaagccc aggaggctgt 139380 gggaagatct ctggcctgct ggaggccccg gttgctggtg ctaagaggag ggacaaggag 139440 ggaccaggga aggggacacc ctgaccactg gagtgctgag gagcgagttg gggggtggcc 139500 agattggggt tagcagctcg aggggcacac ctggggggct gtttccaggt ggatactgga 139560 ggccagccag caggctccct tgaagcaagc cctcatgcca ccttcccagc ccatctggga 139620 cctcaccaca tcttgcttct gggaggaggg tcaccctcga tcctgggcct gctgcctcag 139680 gctgactctt ccctgctgtg gctgagtgag caagctcgga ccctggcctg agggcctgct 139740 tagtccccct ctcagatttg caccggtcag ggccaaataa ctggcttagc caggggaccc 139800 tggaaacctc acttcatttc cttcaagccc taattcctcc attgaaaaac agggccctgt 139860 gcggaggagt aaacgcgaga aagcccacgg ggcatccatg catatccccc tggctcaggg 139920 cctcagcttt cccttctgta aaatgatgct atctcttccg cttctccctc tgccagtctg 139980 tacctccaac ttctacagag cagaccggat gcctctgccc gccggcaggg cacgtcacag 140040 gtaaggggtg ggggctgtgc cccatcctcc accatctgtg ggctccagat cccactggcc 140100 tggtaccatc agtcatggcc aactcccagc ttctccctcc ctcagcttaa gcagccactg 140160 cctggcagaa ggggagccct ggcatggcag gacccttggg gactgccctc aggaagcctc 140220 agtggcaagg gcagatgcca gctgggctgt gtcagggatc ctctgccacc tggcagacac 140280 actacagagc gtggcctttc cctgctgccg actctccttg tcactgagtt ccgtggggcc 140340 acagatgtcc tggccatggg ggtcaatgca gaacagatgt ccatccctgg ccacaatgct 140400 ctgtgccaga aggacagtgc cagaatggcc ccttgctgac acagccccag aacccctgac 140460 tttggaactg ggtggaaggg aagagaggag ccaggtgact ccatctcctg aaggaactac 140520 ctttgggagc ccaggaccgg cccagaagca tctggctgtg gggtggccta cagcctcctc 140580 cccacatggc tggctggcag atggctgccc tggcctgccc aagccacatg cccggcaaag 140640 agttcctctg ccagtgccgg ggcccacgag gaagccggct gtccggacat ttgcatgcaa 140700 ttccgggcag ccccggatgc ttgtctggct tccagcctgg gaagtggcat cgagccctgg 140760 gaagaggaca ggcttcacgg ccacaaagag ctcaactgaa gatctgaatc ctgcatttag 140820 tagtggtgta accggggtca ggggctttct gagcctgttt cctcctctgt aaaggaaggc 140880 taatgtgtaa atgtgagctt gacatctaga gccacatcca gcacagagga ggcgatcaat 140940 gatggctggc tccttccctt cgtccatggc tcacgcctta cacctgctgc tctaggcaga 141000 aatgcccccc tgagaacccc tgagaggact tccagagacc ccaccctgga aactgatccc 141060 accctcctcc ttctctgtga cttccacaca gcctcttcct catcattcct tcctaccaga 141120 ctaaggggcc ttgagggtga taccaggtgt tctccagaca attcaacacc tagcagagtg 141180 ctgcgcgggg ctgccagcat aaatcaatga catctttcag cccagagggt tctgagagtg 141240 attgcatttg acagcacttc ctgaggcgcc cctggcctcc tgaggaatga gctgttcagg 141300 gcatctggca agcagacacc agtccatgct ggcacccttc cttctggaga gtcacccaag 141360 ggagccaccg atcgctgcta gaactggagc agagtcctca aacaacagtc tgcacacaga 141420 caagacccgg gatatttctt tgatccagct cctgccttac aggacttcat cttcacccat 141480 tcctgaggaa ggagagagga aaaaaagacc tctcatacac cccctcagtc tagtgtttac 141540 tgagcacaca ctgtgatctg gataagagag aaactctgcc gtcttggtgc tttcagacaa 141600 tacacatcaa attacattat caacgatgct ggatggcgct aagagccggg gagggaaagc 141660 aagggagtac aggccacaga ccgtcctgga cttcgagttt gacttacatt ttggctttgc 141720 catggtacaa acgccataca cattcagtat actcctccgc ttacagatgg ggttacatcc 141780 ggataaacct accgtaaatt gccttacaat gctttaacct atgatgggtt gatggggaat 141840 ctaaccccat atgacaggag catctgtata ggaagggggc acggttttca acaggtggtc 141900 gcctcactaa gtgggagtca cagggtttca ggggaggagc gttccaggcc gcggtaacag 141960 caggtgcaaa ggccctgagg caggacgggg cagggaggtc cagagtccac cgcgcagaga 142020 cccgggaggc cggcaggcac ggtgaggacc ttgacttaaa cccaggaaag gggaaccaca 142080 ctggggcatg acctcctgta ctttccgaga tcgctctggc tcctgtgttg aggagactca 142140 ggaggggaag gtggaagcgg ggagacccag ctgagacgct actacagtca tctcggcggg 142200 aaaagacggc tcggagcagg gtggtggcag aggtgggaga agaggtcagg tctggggaaa 142260 tttcgaaggc acagccaaca ggatgtactg ccgggctgga tgcggggtgt taggggtcag 142320 ggaggccgcc aaggctctgc ctgagaactg gggagggcca ggggcaccat ttacggagct 142380 ggggaacagc aggagctcgt tttgttagca ggtgcgaggc gccgggcatt taaaggcggc 142440 ctgacgggac cggccgaggc ggaagaacgg acagggccct gcgggaccgc gctcggatcc 142500 gcctcctccc tgacctcggc gtccccggct actgcctcca gagccgcttc ggggccgacc 142560 ccggggactc ttcccgcctg cggcctcgcg ccagcccggc cggctcgcct agtgcccggc 142620 gcccagaaac gcgtggagct gggagaggcc acacaaccca cgccggaagc ctaaccccgt 142680 cggcccccgc ggccggcacc ggccggaagc ccgcgaagcc taactctcgc gagacgcctc 142740 ctgagtcccg cctctccgcg gttccgccag tcgccgcgct cctgtctgcg ttgctgtggc 142800 agccccgccg tgcgtccgcg ttcccggagc cagcgcggcg gcgcgcctgt gctcggggct 142860 tggccgtagc ttttcctcag gtcccgcgcg gcgcgcccct gtgtcgcagg cgccctgccg 142920 ctgcccgcag cttttggggg gttcgggggc gggggaagca gggccgcaga aggcccaatc 142980 ggagccttct gacacccgcc ccggcccgcc gccctcccgg agcttccgtc cccgccgcct 143040 ggctccttac tgacacgcgc gccgcccccg gtcgcccgtt ttccctgggc tccggcctcc 143100 tctcgcttcc agccctggcc tgaggtcctg agggctccct ggagggggcg gcttcccagc 143160 acccagcgtt taacagggcc ctttcggcct ccctgtcccc caagctcaga gttggggtct 143220 gcagcagggg aaagaaggag ggagactggg cagctcaagt tccccagacc gcacctatca 143280 gacggagggc ggcccgctcc cgtcagagcc cgacctcggc ggacagggga ggggatgggt 143340 tgagaagcgg gagaaggcca ctagctggaa actccctgac gacagggaca ccgttctcgc 143400 cccagcccca gcgctcggcc tccgcagagc cggcccaacg aaggaagaat gaaaatatga 143460 acgtgacatg atgtgggctt gagaggccgc cttgttcttt ggattcaccc agaaacctga 143520 ctgaaaggaa agttactgca actggggaaa agcacagttg gctggagaat ttggtttaaa 143580 aataaataag ttttaaatta cgtaactaac acgtgcttgg tgtagaaaat ttggaaaaca 143640 tatgaaagta cggtataaaa atcctcgatc ccactgccac atagaaccac tattaacatg 143700 tcagaatcgt ttcttcgggt gttttttttt cttaatgcat ttatattgca tatacatttt 143760 ttctctaaca atatattgat gtgccccagt cccccacaga ccctaatgta tgaatgggaa 143820 tggaggcgtc tgaaatgtga ctcacaaaga gttctctttc ctccctaaca ccccatccct 143880 gcctcacccc ttcagcgcat tcacagcagc actgggactc cggactcaga caaatgtgca 143940 ctgagctggc tggtgctctc atagcctctg gccccagagc tccaccttcc cctgcagagg 144000 gggtcccggg agtgtcctca agtgctccat gccccatgtt cctttccatg gcaccaaatt 144060 cttctgacct ccttctaggt gaggggtgag ggggtgaggt agggggttgg ggaagagtgt 144120 ccccatgagg cctgaggggc ctgctagtgc aggggaggaa gggaagttca agcaagcagg 144180 ctcaacggag ggctccaccc tccaggtacg gccaggtcct gggagaagga ggggaagcag 144240 tctggtccag gagagaggca gcaagggcag atgctaagcc tttgcctctg cactccctgg 144300 ggacctctgg ggaccccccc ccccacccag cactagtaat caaaggagga cagacaccta 144360 cacacgtgtc ccatatgtct caccctagca ggcagcgaga ggatgcccag tgttactctg 144420 gccccctgga aggctagctt gctctcctgg gcacaagtca gaagcagtgt gaactggagt 144480 gggtggtggg ggacacccct cccggtgagc cccccctccg acccggctgt cagtgatcca 144540 caagtctggc ccatcagccc tccctgctga gcacacagtc cactgaccct tcttcagaat 144600 tgtgggaatg acctcactgc ccctccaagc aacgtgttgt gctgccgccc acatcagaca 144660 tccggggaat ggactgcaca gcctccatgt gtgctggctc cttggcgcct gcagagccgg 144720 gttgattctg tctttccctt caactcttgt cttaaaggat atcctgagcg tgccggctcc 144780 tctgctcaga gggtgttagg gtggcggtgg cagtgggcac ctctctgctc ctcggctggg 144840 tgctcagcct cgccaggctg cctggagctg gtggagcaac agccttgtcc cccgtccagc 144900 tctctgcagc tgccctctcc tgtcagaagc tcctggaaag catttctggc acatagaggc 144960 catctgcatg ttctcctcct gcccgcccca ccccgagtag ccacagagga tcttccccag 145020 ctgccttcac ctccgccccc agacagagcc tcctggctac tcccccagat agtgtctcca 145080 aaatcacttc catttctcct ctgctcgcag ccactcagtg gctttcgtta tcattcagaa 145140 taaaaccaaa gcgtccatta ccatccaacc aaagacccca ggaacgcgct gcagtggaat 145200 caagccacgt ctgttgactg gttgctgtga gaggatgtta ggaaggaccc gcaagtctcc 145260 tcgtgttggg agagcatggt gggaggagga gttgggagag gctcaaggca gcagggctga 145320 ctccacagct gggtatcttg ataactttta tctagaaggc aggaagaaca aaatgcagct 145380 gaagctgaaa ttgatcaagc agcagcggtc attcaaatta gccaggacgg ggtggtttgg 145440 tgacccttga ggtctggccg atgctcatgt tctgcctatg ctctgacacg atcctgtgta 145500 tcttgcccca tctcgggcac acagtggtct tgtctggtgt tggtgttcag tgacattgct 145560 tagccatgaa attgtctcca ggttagtgac tagtgacgcc agggtgggtg gctcttctct 145620 ttttcaagac ctgggtgtca cctgaccccc agctgcctct gactcacctg ccactgccct 145680 tcttatccac actcttcctg acaagctggt ttcctgtgtg gccgaacagt ttcctccttc 145740 gggcccttcg tggtcaccgg gcccctgcct ggagcctccg cctcaggaac ccatgtggct 145800 gactccggcc ctgtggcctt gccactctct ctccatcccc acgctgtccc cttggtggtt 145860 cttactgcca ccttcctttc cacctgctga aaccctaggg tcttctggtc cctctgccca 145920 tctaagaccg aattcccaca acagggagag tctgggtgac acgctggtgc gtttattcct 145980 ggggcagtgt ggttcccaca tggatcctca gatgttcttt ggtgttggtg accccactgt 146040 ggaccgttgg ttctgctcca agaccaaagc tggctgctgg tgggtgcaga atgcgcatgt 146100 ggcttggacc agacagcctc taggcctccc ctttctaccg ccaggtgccg aagggccagc 146160 agcctggaca ccccggagcc ctggagagct ctgaccccag cctctgcccc acctgaagtg 146220 ggtctggccc cttcttgcaa caggatcagc ccccagctgg agacagagac cccacagcca 146280 gcccagacag ccgcctagta ctccccagtc ccccagccta aggacgctcc actgtcctgg 146340 gctgccaaaa caaatatcac caactaggca cctcaaaact catcctctgg cagttctaga 146400 aggcagaagt ccacagtcaa gcggtcagca gagctggttc cctctggagg cttggaggga 146460 gagtccgttt cacgcacccc attttgcttc tggtggctgc tggcaatcct tggtgtccct 146520 tggttcagag acatcgctgc aacttctgcc tctgtcgtcc cgcggcctcc ttcccaagtg 146580 tgcagctgtg tcctctcctc ttcttaccag ggccccagtc actggactta gggcccaacc 146640 caatccagcc tgacctcatc ttaacttgat tacagttgca aagaccctat ttccaaataa 146700 agccctagtc acaggttctg ggtgggcatg gatttggggt gacatattcc acccaacgca 146760 gctcccaccc ccatgtggtg gaagcccagg gtcagggagg atccccgttc ccctgctggc 146820 tcccagtgcg cttccaactt ccaagggggg ctcagtgggt ggtctgagct ggacacaacc 146880 tagctccttc attcctgtga agcatcgttc tcacgggccg tctgggcagc aggcatttac 146940 tgatgtttgg agtaatgggg acagcacttt acaggtgaca acctggggca cctcttggca 147000 gctgggtgcc tccctgtgac ctcagctgtg acctcagcag tgacctcagc tgtgtctctc 147060 tgcccttctt gaccccatca cctcttttct tcccctaact cctggttcca tgggctctca 147120 cctcctctct cccaggatgt ctgagaaaac cacagtccct ctcacttttt gtccaagcag 147180 tccagcgctc tctgcccttc accttctcct ccggcctgga cccctgaagg caagggagag 147240 ggtagagatc acctctcaga tccagaagat ccaaaaacac ccctggggtg taggagtcat 147300 gctgattccc tcggctgtga agcagtgcgt tcttatcgca aagagcactt ctgttttttt 147360 cttctttcta catctgtgct aacattctgt gattcttaga gaacgaaaat tctgaagagc 147420 aaagcccaga gccaagaatg ttcaagccag aagggatttc tatgaggaac aaaacagaca 147480 aggcctctgc ctgcagggtg catatcccga gtggagagat ggggctgtac agacccagag 147540 agcgtggctc gccctggaag ggaaggtcag gtgcgacggg acagaatggc caggaggact 147600 agtttatact agggggtgag ggtcagggat gagcaggatt tagtgaagca aatgatttca 147660 aacatcaaaa gcacaggaaa taaaaggaat atagatcaga cctcatccca atgaaagcct 147720 tctgtgcatt aaggacacta tcaataaagt gaaaagacaa cccatagggt gggagaaaat 147780 acttgcaaat tatctaccag atcagggatt aatatccaga ctatataaag ggcttctaca 147840 aattcactaa ctacaaacct gatccaaaag gccaaggatg tgaacagaca tttctcatga 147900 ggagacacac aaatggccaa tgagcacatg aaaaattctc accatcactc accaccagga 147960 aaatgcacat caagaccaca atgaaaggcc gggcgcggtg gctcacgcct gtaatcccag 148020 caccctggga ggccgaggtg ggtggatcac ctgaggtcag gagtttgaga ccagcctggc 148080 caacatggtg aaaccccgtc tgtactaaaa atacaaaaat tagccaggtg tcgtggcagg 148140 tgcctgtaat cgcagctaat cgggaggctg aggcaggaga atcgcttgaa cccaggaggc 148200 ggaggttgca gtgagctggg atcacaccac tgcactccag cctgggtgac agagtgagac 148260 tccatcccaa aaacaaacaa acaaacaaaa aaacacacca caatgaagta ccagttcaca 148320 cccattagga cgactactgt ctaaaaacca gagaatcaca agtgttggta aggatacgga 148380 gaaatcggac tcctgtgcac tgctggtggg aatggcaaac agtgcagctg ccgtggaaaa 148440 cagtttggca gctcctcaaa aagctaaaca tagaattttc atatgaccca gcaattccac 148500 ttcagagtat atactcaaaa gcaaggacac caacagacat tggtacacat gttcttagta 148560 gcattattca caacagcaaa agctgggcat gacccgtgtg tccctcaaca gaggaatgga 148620 cagacaccac gtggtttgta tacacagagg aatcttattc tgctgtggga aggaatgaaa 148680 cactggcgct cactgcagca cggatggacc ttggcaacac catgccgagt gaaagaaacc 148740 aggcaccagg gcagactgta ggattccact gctgtgaggc gcccagagca ggcaaacttg 148800 taaggagaga aagtaaagta gaggttccca ggggctgggc tttggagtgg aacagggact 148860 tagttactgc ttcatgggga cagagtttct ctttgcagta atgaaaaagt ttttgaaata 148920 gacggcggtg atggttgcac aacattgtca atgtcctgaa tgccactgaa ttgtacactt 148980 aaaaatgggt aacatggtaa atttggtgtt atttctattt accacaattt taaaaaatta 149040 gtactgtact ataaaagcca tggaatcgca cgctttccat aggtgaattg catggtttgt 149100 gaattatgtc tcattagaag aggagcattt aaaagaaaga gggaggccag gcacggtggc 149160 ccacacctat aatcccagca ctttgggagg ctgaggcggg cggatcacct gaggtcagga 149220 ctttgagacc agcctgacca acatggtgaa accccatctc taatcccagc tactcaggag 149280 gctgaggcaa gagaatcgct tgaacctggg aggcggaggt tgcagtgaac cgagatcacg 149340 ccactgcact ccggcctggg tgacagtgag attctgtctc aaaaataaag aaagaaagaa 149400 agaaagaaag aggggcagca gcccccacat gcagccccca tgcaagagcc cccaaggaga 149460 ggcttgatgc atcagaggtg ctgggtggtc tggcaggctg gagccaggcc actggggagc 149520 tgggagcaga gggaagtgtg tggagggcag ccctgccccg ggttctgcag cagcccccgc 149580 cttgtctgcc tgcactgctc tcggctggtt ctgtgctgag cgcagcctct ccttggaagc 149640 caattttctg cacagtgaaa tgtttttttt gtgcccactt tagcagatgg ccccccacct 149700 tggcctgaat tgggaagcac agaaatgcag caggggacag acggcttctt tggcaatgtc 149760 ttacaggcac acgagcacgc agactcatac ccgcccccca caactcgcct tcacggactc 149820 tgggctgcag ccggcctccg gagacctctc ctcttctgct gccgaccagc tgctggacgc 149880 ctggcccagg tgcttgcttg ggatggatgc agatgactgc atgtctccaa ggccgggacc 149940 ggggcgcttc ctctcctgca cccgcccctc tcggccagtc cctccactcc ccctaatggg 150000 agaatgctga agggatcctg gcagggactc ctgacctcca gtgtggagac cccgccccag 150060 gcacctgtct caaccccatt tacagggtag ctgagaaact tctggggaga cagcctgacc 150120 ttggcccacc actggagtcc agaccttaaa cccactgtgg tcagtaggca ggagtctggc 150180 ctgaggtttg aggaagggca acagagtctc cagtggggaa gtcgccattg aggaaaagtc 150240 tagtgaaagc agatcctagg cccacgggac caatggtgtg tcagggccga gttccagggc 150300 cagcagggag gagggggctg gtgcagggag ggttggtagc ctccacagag ggatgccacc 150360 ggtcctcatg ggttggagcc agcccttggg caccagagag agcctgaagg ggctacagag 150420 accatctgat cctaccctgt tgttctaatt tttttttttt aaagacggag tctagctctg 150480 ttgcccaggc tggagtgcaa tggtgcaatc tcggctcatt gcaacctcca cctctcaggt 150540 tcaagtgatt ctcctgcctc agcctctgga gtagctggga ttacaggtgc ttgccaccac 150600 acatggctaa tttttgtatt tttagtagag atgggatttc accatgttgg ccagactggt 150660 ctcaaactcc tgacctcaag taatctgcct gcctcagctt cccaaagtgc tgggattaca 150720 ggcgtgagcc accgcgcccg gccctaacct attgttctgt gctggggtgg ggtggggaag 150780 atggaggctt gggaggccac tgcccactcc tcatgtgacc aggtcagtct caggaaatgt 150840 aagtgtcctt cttagaggaa ctgggagaca aagggatttt caggtttcgt ttttgttttt 150900 gagacagggt ctcactctgt cactccaaca cacctcagct tgcagctgtg tccctccagc 150960 ctctgactcc atcatcacag ggccgtctgt cttcctctgt gtctcttctt ttttaaaatt 151020 tttttgtttt taaaattttt tttagatgga gtttcactct tgttacccag gctggagtgc 151080 aatggtgcga tcttggctca ccgcaacctc cacctcctgg gttcaagcaa ttctcctgcc 151140 tcagcctccc aagtagctgg gattacaggt gtgtgccacc acacccagtt aatttttgta 151200 tttttaggag agatggggtt tcaccatgtt ggccaggctg gtctcaaact cctgacctca 151260 ggtgatctaa ctgccttgac ctcccaaagt gctgggatta caggtgtgag ccaccacacc 151320 tggcctctcc ttttcttata aagacaacac atctgcaaag accctgtttc caaatacagt 151380 caaattcaca ggcaccatgg ttaggacttg gagctgtatt tctgggggaa acagttcaac 151440 ccataacaaa ccaatgtggg ggtacttttt ttttgacaca gggtcttgct atgtcaccta 151500 ggctgaagtg cagtggtagg atcatggctc actgtagcct ccacctccct ggctcaaggt 151560 atcctctcac ctcagcctcc acagtaggtg ggactacagg cacgggccac cactcccagc 151620 tttttgaaac tttctgtaga gatgggggtc tcactatgtt gcccaggctg gtctcggact 151680 cctggactca agtgatcctc caacctcggc ctcccaaagt gctgggatta taggcatgtg 151740 cttccatgcc cagccgattt ccaggtttta agggtcaaac tgttggaaac atttatttaa 151800 aaatccagta ggagggaaat gtgtgaccag tgagtgcaga gggagtctgt ggcatttcca 151860 ggaagcaccc caggccaggc cttgagcatc tgggagagga aggatgttca ggccacgggg 151920 cagacgtctc cacaagccga ggccacaggg acttagctgt gcgtgagtgt gggtgtgtga 151980 gcagccagct cctcgagctg aaggagctcg tgtgccagcg agagggtgct gctggggatg 152040 agcccacccc cggctacctc gtagggaatg ggcacaggga gaaagcagga ctccctcaac 152100 tgggatgccc ctgctccagg agcccacagc tgggctcaag gccgtacaca tgcccggctt 152160 cctggagcac caaagacagg aagagggcag ctgggggacc tggagccgga tgccctttcc 152220 caggataaat gtagggcttc cagaggcctt gcatttgcag ggggccactt taagccacat 152280 ccccagacct tccagggctt ggtccagctt cccctgctgc tgcttatggg acctgggtgg 152340 gggatttgac aagtcctgga gcagctcagt gggtggggag ggagagatcc aaggacaggt 152400 ggcctgcagt cctgcgtggg ggcgggggac gcagccttca ggagctgaga aggggacctc 152460 cagacatccg gagcttcctg gtatggatga catgggaggc actggagtcc gagggctgca 152520 gctggggtgc cccatggccc aacctgaagg caacatttcc cagctcccct tggttctttg 152580 gcatcccagg agggactggt gcatggggag gggcctgtgg gcagtggggg cggcgtccgg 152640 ccttcaggag aggaacctgg aggagggtat cctggcatgg cagaaggtag tggggtctgc 152700 ccccaattgt acctgctcgc accaggccct gtgcatatag ctcctcatcc catcttcacg 152760 gccctgagag agagtactgc cagccccaca gcacaggtca ggaccctgct gtttagccag 152820 gccaggcgag aacactgagc tgggagtcag gaatcctgga ttctgatttc tggatgtcaa 152880 gctgtgcaac tctgaatgag ccacacagcc cctctgrgcc tcggtcccct catctgaaca 152940 gtcggggaga cagactagac gaccctcaag gttctccagg cccagacatc ctgcaggtct 153000 tggacgtagc atctctgtcc atagcgacag agacagaagt acccgccatg caggcaggct 153060 gcccctggcc cagtgcaatt tgaggaggct gctgcatggg ggcagagctg gtgaagactg 153120 agggaccccc gtcttcctgt gttgggacag atgggcagga gctgtagctc aatgcaagga 153180 accaagcatg aaatgacaga aaaagaagag acgggagcgc aaaagaaaac ttgccgatag 153240 tcagagccgt ctgaaaatag gacagactac ctctctgggg taatgagctc cacatcacca 153300 gaagtgtgca agccgagaac agtttcaggc acctgagagg ctgctgaagt taatgacttc 153360 caagacaccc tctggctttg acttcttgcg cccgtgtccc gctgcccaga ctcccacctc 153420 actccaccga gctgcaaggc ccgtggcttc tttccaagca gctgttctta gctccacggc 153480 cccctgaagg cattcatgga tgagccaaaa tcaggcgtga gaagtgcaga aagtactttg 153540 catctaatga tagttaagaa cccaagtgtt tgaatgagct ctcacataga gattagaaat 153600 gtatgcgtga cgttatcaca gacgtaactc tgcactttct tgagtgggag gtgtgaggcg 153660 gtgtgtccat tggagccact ggaatcgggc ataaccctgg gcccgaccgt gagcgtgcac 153720 cctggggtga acaccaccca gcgagaatgg ctctgggaac acaggccagg ggcctcccgc 153780 ctggcagggc ctctgtctcc cgaccaaggc tcttcctgca gggacacagg gggttccctg 153840 cctgctttgc tgaggccaaa ccttctccct ccacaccatc ccaggtgaca ggtggctcac 153900 tcacacccac taaacccccg ctcctgagtc ctgggaacac cagagcaccg ggcagagaat 153960 ccccgggcga tgccaacagg aagccagagt gaccagtccc ttccgccaac ccagtgtgtg 154020 tgtgtgtgtg tgtgtgtgca tctgtgtgtg tgaggtgggg ggcaccaacc aaaccaccgg 154080 gcaggtgatt ttggctccat gtcccctgac ttcaggttgt aagtgtgcta gaatcactca 154140 ccccagggca cttgggtcct ggttactctg tcccttggaa ggaacagctc gcaagctcca 154200 aacacatcca gagtcaagcc aggtccacaa gggggacagg gaagtaagct cagcccaagg 154260 cccagcgttc ccatggctat ttatcccttt gtagggacac tctcagacac tctcagacaa 154320 gtgcagggaa ggggcctggg actctgaaag cgggaaggca accacacgtg gctaaggccc 154380 cgctagcaga ggctgaggca gagaactgcc agagttgctt gggcacgaca agcccgggcc 154440 acctcgaacc cggacccagc tgtggaccgc gagtccaccc aggaggggaa ggggaatgcg 154500 gagtgacccc acatcccagg ccgagtggcc tcactgagtt ggggaaacac tgggccactc 154560 tctgcctctg cgtcagctgc ccctgggaaa tggagacccc tccacccaac atccagcatc 154620 accagacggt gtggggttgt caaagggcac agggcaatgc acaagcgagg cacacacccc 154680 ctgcaggtga gggtcacctg cacctggctg gggaagaggg gtggctgcag ggggaggtgg 154740 cattggcaag cctcggaaaa gaagagacat cctgaggaga ccacagtctt tctccactct 154800 ttactgtgta aaaataaact caacaattca tgtcatttca gcaagaaaat gaaaaaaaaa 154860 aaaaaagcaa gaataccagt agaaatagtg catttccaga attgctgatg ggaggtggca 154920 ggtcccatgg ttttgaccca tttgataccc aaaaggctgc agatcatatg aaaaatgtac 154980 agctttggtt agcaaataat gaaaaagtga gatacatcga ttctctttca tattatacag 155040 tatatacatt ataacaatat caaccatagg gggtttgctt tttttttttt tttttttttg 155100 gcaaatgaga caaaattggg actctaagta ttgggctttt tttttctctt caatgacttg 155160 ttccctttca acaaattgca cttcagtcca ctgtgtacag aagtaataca tttcccatcg 155220 ttagttgaat aaatttacac actgtgttta agagatgaaa ccacgacttc gtcaagccac 155280 atttggttgc cataagattc caaaggattc tatcctctta atgtgaacca catgtaaccc 155340 aaggttcttc tatcaaggtt agaactgata ttcaaatcct cggctcattc cacttagtaa 155400 gtcagctcca agacacaggt tcaccataaa tggccagttt tacctcctgg tccccaacat 155460 gcttttgaga acaggtggcc cctctttgga gctcactgga atgactgaac ctcatgccag 155520 cctctcctca ccccctcact gcccacaaga cacccccttg gtctcaggtc ccagggctgg 155580 tgacaaagtg atctttgcag tcttagaaaa taaactggga atctacaaaa ggaaaagaaa 155640 gcatacaaaa tgtatctctt tcttccaaaa tacatgcttt cagttctacg ttttggtgga 155700 gcctgaaagt attttcaagg gagatatagg ttgagttaat ttataggttt gtccttttct 155760 ttcataaaaa tactcttgtt tggtaataaa ctttttcttc tacagtaaga gaaataatac 155820 tgtgttatca aaagcaagaa ggcttacgac tcaagtggga tctaagcccc tgagggcccg 155880 gagagcttct gtcaacagct ctcccacccc ggacacccag ggagctgtcg gacaccagct 155940 cggcaaaagc aaacactgcc tcaacagtgc tttttatctt cttgttttat aaaatggctt 156000 acctgagaga ggcatgtatt attcagtgca agagggaaca tcaatcagat taaggagtaa 156060 atgggaacta cgtggattag atttgcggct gtgtcatcga cctttctcgg ggccagcaaa 156120 gtgccaagtg tcaacacagt gagggagtcg aggggcttgg ctcagaccct agcaaggggc 156180 aggagggagc taaaggtcag cttcggccct ggcaccatgg gtgggtcaga ggaggggtga 156240 ggaaggtgag cgggccagga ggctgcaggg gtggaggcgt aagcactggg gtgtgctctg 156300 cccctcgcta gtcagggcag aggatggctc atggtcctga acggacagct cccacctggc 156360 ccacgggggc agaaggtggt ctgcggtcca gtagatcggc aggggcgggg ctggccggag 156420 gtgctggcag gggagcaccc cacacagccc gcaccgggcg ttgcctacac aagggctccg 156480 agatggctgg agtgagggtg gggctagatc tggtctagag aggcgactcc aagctctctt 156540 gctggctccc agctgtggga atcctttagg cttgttctca acctacacgt taaaaatgct 156600 tcttggtgtg tttggggagg gggagaggga aactgagctc tctcttgacc tcctccaaca 156660 cccttgactt gcttacccag ccattttcag tagctacacg ggtggtcaca gaacactggg 156720 cggcactcgg cacacaacac agaaccgggg cagtccatgc aggtgcggga acacatgtcg 156780 gacccaggga gcaaggaaca cgccaccccg aggaacatgc aaacggagaa gatccctgca 156840 gatccaagga tgccacaacc cgacgggcgc tgaggaagca cgattatcta agaaaaagcc 156900 actgttgaac aacaacgcgc agcacggcgc ctgatctgca cccccctctg cgggagtgat 156960 gcattgcaga acggcggccg ggtaccgtgc agacacccac gagaacactg acacagagac 157020 actgacagac acacacagat gcactaggtt cttgacacaa cgtggacctg tgtttaaggg 157080 gacaggtggc cctagaagga acagaagaca gaaacacctg ctcctcctgc agaaatgtct 157140 gcagctgcag ctgagccagg cagtgcagta gaatttctag aaagacttgt cagcggtttg 157200 ctgatgagac tcctggagac agagtcgggg tgccctcagg gcgtgcgacc accagatggt 157260 gcaaagcagg aagctcctcc taccctgggc agggcctccc gagcctgctc tctttctcac 157320 ttagcgcaca cacacacaca acacacacac acacacacaa atgcacatac acttctctcc 157380 cctccttgga aggactagaa ggaaatgtcc atgttgcttt tcacggggaa caaaaaaagg 157440 caaaaaggtt ctggacactg ctcaggtgtc agtgtcgccg gccagtggca gcttgtgggc 157500 tgctgtaggc cgtgagcccc atgagatgga ggagtgggtt tcaggcccct gccctggcca 157560 ggcctggctc cacacgtgag gtctctggag tacccctgga ggggtctgaa ccagctcacc 157620 tggcgcctgg tgtgctggga gggatatggc tgtcaaagtc ccccaaaaag gaccttccca 157680 ccgatgggct gggttgaagt cccagtggcc ccatgtggcc aggtcttcat cgaaacacgg 157740 cttctttcct taaaaggtcc cctctggtct gcactgccgg aggccaaagg agaggggtgc 157800 tggggcccgg cttcccgggc tgtgggtggc acgctcctct ctcagggccc tctgggctga 157860 agcagtgcag cacagctcca gaggtgagaa gggaggggca gaccccagcc ttgcaggatc 157920 tgaggaggtg ggaaggtcga gggcagggcc gtcctggggc agagctagct gagctgggca 157980 cacaggccga cctcccaggc cccatgctgc tctcagatgc aaacagcagg gatggatgct 158040 gtctggccct ggggtaaggg ccagtgtcct cagccatccc ctctcctcca cgggagagca 158100 cagggtacca tcccaggacg gcctgccttc acccttcaga gacagttcac ttctattaca 158160 aaataaaaat tctctgtaga gagcccccgc ccccggcctt tgacaaacca ctaaaagaca 158220 tttattacat caatataaag atatgtcgct ctgagaaagg tttgcaaaca aagacaaatg 158280 cgtgtactga ggttgcacca accccaaagc acgcacgcag ctaacaaagt tggcaaatat 158340 gaattttcat catgagattt ttccaaagcc agaagaaaga aggaaatgag gtacgtcctc 158400 aaagaaaagg cctcccccag ccacgcacgc acacacgtag acacacacat gtagacacgc 158460 acacacagat cctctcacca acttctgcct tgttcaagac gttgcagcac ccacttcagc 158520 tgtgaatggg gcatgcctga gagagtccgg gctcctacag agaagtgggg cttcctcagg 158580 gacagatggg agcaggggct gcttcgtgtg catgaggaca aaaccaggct gtgtgcgtgt 158640 gcgtgtgcag gggcgacggc ctcggttcat tcctggggaa aagggagaga agagacgcac 158700 aaaacagatc atcgccgcac aagcaggggg cgagggcggg cgggctcagc ctggcctgcc 158760 gtgctcagtt gatctggcga caggcctcga aggtccactt ggtggcccct ccgtagatct 158820 cgatgtggga ttcagcccag gcgatgacat tgccggacag agccttggtg ctgcaggtgg 158880 ccaggttgta cacctccccg ggggtcagct tgcggtccca gatgttgaag tgggccagct 158940 cacccacaaa tgcctgggtg gcatcaaacc caccacccag agtgtccttc agagaaaaac 159000 agaggatgag agtggagggg tcgccaggtg gtctgggggc ccatccctag gccggggatc 159060 tgagtgcctc tgtgcctgcc cgatcacgga ctctcacgga cactcctagg tgccgtttcg 159120 tctccctgtc cctgactctc cagccctaca tccatccctc ctctggggga gcccaagaaa 159180 agggatggca ccgaccacct ctgccctgga gcttctcctg gggggacctg gactctgccc 159240 ctcctgcagc tggtccctca gccatggaca accacagcag ctgggcctgg ggcccctgcc 159300 cagacatcac tccatgccag ctaaagctgc ccaacaggga cagacgtccc cgattctcca 159360 tcccttcgtc ttcctcccag gtgcccaaca ggagacaaac cacttcacgg gaactagatt 159420 atgcatcact aaaagcagaa ctggccttcc catgccaaag aaagtgttgc tgcagctctg 159480 agagcgttga aaccagagct cactcctgca ggaagttcaa gtgcatgtcc acccagggca 159540 caggccttgc ccagcctgct ccccgggctg cttctcaggg gaaccacttc tccggctacc 159600 tccctccctc cttgctcctc ttccccttcc cagcctctgg ttctgaagct ctctcccctt 159660 ccccaccaca tccagcacag tacctgctcc tggcccagca ccagcacgcc ctggggcttg 159720 atggggtgat agggcgccaa gttctcgcca ctgccaccct gcgtgccatc ctggtaggcc 159780 tcccagaccc cgtcccgggt ggtccaggtg acacagatgt ggtgccactt gccatcattg 159840 atgacaaaag gcaacttggc cacctgggaa ggagaatgac agacgccagc tggtgagtac 159900 aggggtacag cccagaagcc ataatcttca ctgcctcagt tgttcctatc tctacttgca 159960 aagtaaatgt caataactat tactgaattc tcacagcacc tactgcccca gacttcagcg 160020 tctgtcagcc ccgcctgggc gtggggcaca gaatcacaca ggaaatgtaa ggctctaccg 160080 agggaacccc caagggccat gtgggtgtgc agtctcttca ctcctactca ccctcctccc 160140 tctttgctag tctacacaac aagccctagt ctacaccagg gagagccgtc cctggtgtct 160200 gagttcactg ctgcctctca aggctccgtg cgacatctgt gcagcctcct tgctggcctc 160260 tcctctctct tccgatgtcc catctctagc tgttacaccc tctcactcta caacacggca 160320 agcttttgcc gaggatctga gagatgtcat ggagcacgat gccttttaaa gctcagacca 160380 gcctccaacc tggaatttca ctctcccact gccattccag gtcgggagga tgacggtcca 160440 gcagacagtg aggaaagaaa cttcacaccc tttccgcttg gggaaagggg gcccagaatg 160500 gcacagccct ttgtggggaa gagcaacagg aacaagggcg tggaatccac ttcccagccc 160560 aggttttagc cattgactac cactgctggc ctggacttga gacagtttga aagctggcag 160620 ctagttccat agctaacagg ggaggatgga gaatgttcac tagagggaaa ggctgcctgt 160680 gctgtcctgt tccaagggat cacacagacc tgtcctcctc ccgagagtta gggggctgag 160740 tgggatagac ttggactcag gaaaaatctc taaggacccc tcaccccgct agagcatctc 160800 tgggtccctg ctatggaggg gcaaagccag ttccaaggcc agctggtgga ggagtccaga 160860 tcacatcatc gggcagggcc aggccccatg gctcgttctc cgccatctcc cgtacccacc 160920 ccaggaggca tccgggaagg tccagctctc cctgctctcc cagtacaggt gagggggctc 160980 ctaccacttc tcctggtctt caccctcccc ctccctcagt cccacctggc aaacactttc 161040 cttggggccc catcaacatc tgaggccacc atagccctgt ctccgcatgc aacatgagct 161100 ggggccctgg ggcctcgccc tgccgccctg tgagcccggg ggctgctcta ccttgtcatt 161160 gatgaggatc tccatggggt tgttgcccca ctcaatgagg accagctcgt tggcctggcc 161220 gggcacagcg taggagaagg gcgtgcccac acctggcgtg gcgctggact tgagccacat 161280 gcagacagtg aaggcgtaca tctctggcag gctcttcttc accttggcat acatatagtt 161340 ggtccgcagt gggaatgtga gctggaactt gtctccaggg cggttgtctt tctgacctgc 161400 ggaagacaca gtcctgacat ctgcacctgc gtgaagtgct tatcggtgtc tgagttgagt 161460 tcggtcccca ccaagctctg tgatgcgtgg ccagggcagg ctccggtctc cattctggag 161520 acgcagagcg ggtagcttcc caggtcaagt actttgcccc aaggcacagg gccagtctgt 161580 aaagagctga cccaagctct tcatgctcca ggtctggcct gctgtcacgc ccatgtgctg 161640 gcatccttgg ggagatgggg gtggggggca gtgcctggtg ggctgctgca tcaacactgg 161700 gctgcgtggt gggcatgaga agggaatggg gacagccgcc aagccaagtc aacccaagga 161760 gcaggggtgg ctgcagagga ggaacgaggc tagctaccct gagagtaacc gacctgattc 161820 caggatgggg cggggctcag agcctctcct cgctcaatcc caggctctgc tcctgcctct 161880 ccccacccga cagccaggcc ctggtgccca cacacttccc tccaggccag atgtgcctct 161940 gacccaccaa tgcctcttgg gtgtgaggct gggcagctcc ccacctccaa ggcccttcct 162000 tggagcaggg actctgcctg gagctctgct gagagggcag ggcagcaagg agctgggagt 162060 actctgggcg ccagggctcc ccaaggtgac tgctctagga tgccgccaca ctctcaggtg 162120 agtaagtgtc ctcacagctc aggttccagg cctggtggcc tccctttcca caaggcccac 162180 cttctccctc cccaccggcc acttctcccg taagcgccaa cccccatagc ccatctatat 162240 actgtggcac cctgggtatg gtgtgactga ctccaggcaa aacattcctg gccagcaatg 162300 ggcacagtag caggcccaga gcccaggaac acacacccct tggtcaatcc ctgggtgagc 162360 agccgtggtc ctgccaggaa gcccagaaag aaaccagttc cccaggccaa aaattatttc 162420 tagaagacat cctgcccggt cagcaaccac cccctcctct aaaccaactg gcagggagca 162480 gagcagggca ggccccctca gtgcagcacc ccagcggcta ccccaaccca ttgaggcctg 162540 cagtggggga tagggagggg cccagcccct ggcctttctc cgggtgtttt tcattcccca 162600 atctccgctc cttccctctc cctccctcct gaggtccttc cttctgatct gtttttcagt 162660 tacataacaa gccttaagat ggcactgttt aaatctgtcc ggcacatttt gcggtctgag 162720 cagggtcacg tggccttgct ccgcaccggg cacccccccc cctccccttt tacaaccttg 162780 tttgatttct gcgacttcaa gacagagcct ccagcgctca tccaggcgcc ctgggtgata 162840 gactggctgg cctgagttgg tgactgagaa acctcaggga tttgaaagat gccaggactt 162900 gggtcactca gaaaagaaaa cctcagggta ggggttcagg acagaagtgg ggaggagctg 162960 gagatcctga gaggacaccg ggggcatggc agccgggaag aaacctgctt aacagcctca 163020 gcggcccggg gaacgagagc gcccagcccc agcctgcacc cagctgtacg ctgaggctgg 163080 ggaccaggga gagacaggct ttcttaagca gggagggttt gagccagcga cagccactgt 163140 gcaaagttac tgaggattaa acaaatcaga cttgaaaaat ccagcgagtg tgtgagtgtg 163200 tctggatggg ggagggggca ctatgcaatc ccctttccca gagacagccc cagcccaagg 163260 cacccagccc tgatagaaac accgactaga agcccagaac ctgggaaggg gtgcggggaa 163320 tgagaaagcg gtgcaggggt tgggggtagc ggagcggctt gaggcttgca cagtgcagag 163380 ctgggctgtt agggatcggg accgaggcag ggtcgggcaa gcaggtgcag gcaggcagca 163440 cggctccccc tggccccagt acctttctcg agctcgctga tccgctggtg cagggaggtc 163500 agggcggtct cgatcttgac cctctcctcg gtgtcgttcc tggggccccc cttgccctcc 163560 tccagggtgt tcacccggga cagcacctgc ctctccagct catcgatctt gctctgcagc 163620 agatccttga ggctgttggt ctggctggag gaattgaggc ggctgtactg ctgcggggtg 163680 caagggcggg ggaaaccaca ccgttaggcg aggcgcgggg accgtgctgg aaggcccgcg 163740 gcgcggtccc ctctgggcga ctgcgggggc ggcctggcag ggagctgggg cgagtggccg 163800 ccgcggggcc tcgcaggcgc ggggaggcac cggccgggca cccgcgcggc tgaggcgagg 163860 gcgggggatg cctggccggg tagggaacgg ggtgggggag ggcagagggg cgagcgagcc 163920 ggagggggaa ccggagccga gggcgcgcgc ggacctcgag gttctccagg cgggttttga 163980 gcgattgcaa agtttgcccg agttggctga gcgtctcggc ggccggtgtc cgggacaggt 164040 cgcccatggt gttcttgccc gagccgggct gcttgcggcc gccgcccgcc cgggcctcgc 164100 cggctccggg gtccagcgtg ctctggctct cgcagcggcc cagcttggcg gtcagctcgc 164160 ggatggtctc cttctggctc aggatggtct ccttctgctg cagcaccgtc tcgcggagct 164220 gcagcacgct gctccggagc tcctcggcgc cgccggcggc cacggacgcg gcgcacatgt 164280 cggcgtccac gggcaccgag gtgcagatga agcgcgtcgg cccgaaatcc tgggccccgg 164340 cgcccaggag gcagagggcg agcagcgcac aggtgcgcgc ggcgcggccg gccggcatgg 164400 ctgcgggcac cgggcgctcc gggcccggct cggctcggct ggggctcggc tccggctggg 164460 acccggctcg ggctgtggct ccgcgagcgg cccgcgctct gggcgccgcg ctcttcggcc 164520 gcgcggtcca caccgccgcg ctatcaggcc cccactgccg cctgcgctgc ggagcccgcg 164580 ccttttatgc cgccgcggga ggggcctcga gccgccgacg tcagcggggg aggaatcccg 164640 ctttaattgt ccgcggcccg ggcccgcggc gcggcggggg tctcacgagc gcgccaccgg 164700 ggctgcctcc gctcgcgtcc cccccgccct tctgggagct gccgcggccc cctcctcccc 164760 cgcccccgcc tgggccggcg ctgctgcccc gaaggctccg agagctcagg gggaaggaag 164820 tcgggctccg gccccggact cgaggatgga ccacctgcgt ggtgtccccg aacctccgac 164880 ggggctccag gcgggcggga aaccaccgcg tccgggagat agaattcggt tcggccctcc 164940 tggctgcact gaacaccctt gggccggggt cgtttggagc cgggctgggt gcccaaggac 165000 ccaggtcgtc aacacccgag tgcccggtgg tcaacggctc ggagtggggc ctcgcggcgc 165060 cactaagtcc agagcggggg tcaccgggcc gccccgcgtt tcttagatgt ccgtgtgcta 165120 ttgagaagcc gccgggcagc ctgggtacag ggacttccca cgggtcgggg cccccggcgc 165180 ctcccctccc ccagctcccg ggctctgtgg acccggcccc gtccccgggg gactgtcagt 165240 ccccaccccg tgcgggcggg gcgctgggga cttctcggag gcagacctag ctgatcgagc 165300 ctttcctgtc cgcggcgccg gcccgatcgc gggcaggcgg cgtcgccggg gctggacgtt 165360 cgcagcggcg cttcggaagg gggccccgcg ggagcagccg cccgcgtctc cagcagcttc 165420 cccttgccag gcgccgcgcg cgcccggtat ccccgggtgt ccacctgtgc gtggggggct 165480 gtttcccgtc tgtccagccg cgcccacttc tcaggcccaa aggccagcag gaagggtccc 165540 ggaggtggct gggggcgtcc acctgagaag ctccgctctc gctcagacac cccacccggc 165600 acccgcgcac tcgcgccttc atctggaccg cggggctcgg ctcccgagat cgcggtccgg 165660 gttccggcgc cgggctgggg gctcaggacc agggctggcg cagccgcccc gccccgcccc 165720 gccccggggc tatcagagcg gtcaaagcct cggaaatccc tccgtccacg ctcccgtggt 165780 acagagaagg aaactgaggc tccgagactg cggggccggg ctacagccgt ggccccccga 165840 cccctccccg ccgcccccgg cttctctggt ctctgcgttc tgcagccttt ccctgcgcgc 165900 agccgggggc tgggggtccc cagccagcag ggacccacgg gcagtcccgg gtgccgggat 165960 cgggcgtccg cccctcgggc gggagcagag gccggctcga tggagacctt tttgagaaat 166020 ggcggcctct acccgccccc cagcccccga gcgcccgccg tctgcgttca gcatctcagc 166080 ttttaagcct ccctgagccg gggctgcgtt ctcgttgtct ccttcggccg ccgcttcctg 166140 gcgccagagg gaccccgcgg cccgcacggg cctgtcctcg gctccgctcg gagggtgtgc 166200 gggttcccgc tccgctggcc ccgcttgccc accacggcgc gcccaaaccc acgcggcccg 166260 cggccccttg cgtgctctgc cgaccccggg ccgcaggagg ggttagcctc gccggtcccc 166320 acgcggggtc tgcgccggca gcgccacggg ctggaacgcg cctcgggaga aattacccgc 166380 gcggggtcgc ggcgtcttct gccccaactc ccgtagggag ccgctaggcg ggtgccctcc 166440 tggccccagc gctttggcct cgccgccctc ccgcacgcgt ccagtgggga ggccgcgccc 166500 gtcaggcctg gagccggacc gtgcccagcc gagagcgcgc gggcgcggga gaggagccct 166560 gccctgccca gggcaggctg tttagacggg gcgggaaccc ttagcctggc cccgcgtctc 166620 tatccccagc agccgtggag ccttcctagc cgcccaaggc cagggaccct gcctggcttt 166680 tcctccaggg cagcagatct cagcggcctg gcacctcggc acagaggagc gtgtccccct 166740 tccgcagagg aagggagtgg acggcgtcag aaagggaggg gagcctgggg cggtgtctgg 166800 ggctagcggg acctctgggc actgtggggc cccaggagag gagaccctcg ggtccagcct 166860 gcaactgttg tgcaggaggc gctgggcggg acacctgcag gcgctgcaca cacacgcgag 166920 ggccaccatg ccgcgtttct ccttcacaag accctgggca agcggagggt cgtatttagg 166980 attccctcgg cctccccagt gttctgaaag tatctgagag ggagggagca ggaaaacgaa 167040 gggccgccct gcccaaactc atcggggtgt ctggttacta ggtcggaaga ggggggatgg 167100 tgttgtgaac agccagtgat cccggccctg cctgagtccc acaccccaga tgcagctggg 167160 gtgagggagg cgatcccgta atattcccag ccgcgtacat ttgtggctgc ctgtgacacg 167220 acctcactca ttgggaaacc atgcacacta gcacactgtt attttatttt tgagacaggg 167280 tcttgctctg ttgcctaggc tggagtgcgg tggcgcaatc acagctaact gcagcctcga 167340 cctcttgggc tcaagcgatg cttcctgcac caccacactt cagctaattt tttttgtttt 167400 tttcgtagag atggttgaac tcctcttgcc ttggtcttgg gactacaggt gcaagccaca 167460 gcgcccggcc tagcacaata gtacttatta tactactccc accataacgg tgcaatagat 167520 gtgaataaaa ctcaaaagca tagacaaggc tgggcgcagt ggctcacgcc tgtaatccca 167580 gcactttgga aggccaagct ggatcacatg aggtcaggag tttgagacca gcctggccaa 167640 catggtgaaa ccccgtctct accaaaaata caaaaattaa ccaggtgtgg tggcacacat 167700 ctgtaatccc agctacttga gaggctgagg caggagaatc acctgaacct gggaggcaga 167760 ggttgcagtg agccgagatc gaaccactgc actccagcct ggatgacaga gcaatactgt 167820 gtctcaaaaa aaaaaaagat agacaatagt tcaatgtaag aaaataatta gaaagtgatg 167880 agtttgtagt atttattgcc catttaaaat ataatttatt taattataag tttacttagt 167940 ttaaaatgta atagtggctg tgtttaacca tcgacctgtg aaattcctgc aaatgccacc 168000 atcagtgggt actggccggc tcagctcact cctggtggaa gggcacggag aggcctgcag 168060 aggttagttg gtagtgggag ggggagtgta gagaaggcaa agggggcagg tgtccaggag 168120 aggccctggt tagtggccag tatggagagg gtggccaggc ataagaagac tagacagacc 168180 gggtgcaggg gctcacgcct tgaatcccag cactttggga ggccgaggtg ggtggatctc 168240 ttgagcccag gagtttgaca ccagcctgga caacatggca aaatctcatc tctacaaaaa 168300 tacaaaaatt agccaggcat ggtggggtgc acctgcagtc ccaactactc tggggactga 168360 agtgggagga ttgtttgagc tcgagaggtt gacgctgcag tgagccgaga ccacgtcact 168420 gcactccagc ctgggcaaca cagcaagatc ctgtctcaaa aaaaaaaatt ttaaaaaaag 168480 aaggctagcc gggtaggttg ggaggtatta agaggacctc agtgcccatc aagagtcttt 168540 actcagtgga cggtgggagc tcatgcaggg gtgtgcctaa gcctggtggg tgcctgtgcc 168600 ccttgctcat cctgccgtat ctccccggcc tctcatcttc caggccatgc cttgagctta 168660 tctggaacct ccacccttag caggaagaag ggtgagcaat gggtgggtgc tgggagaatg 168720 ctgggagggc ctgagagcac tgcggggtgc taggcagagg cacccttctc tgccccactt 168780 gcctcagccc ttcccgcatg atgttccatg ctgcctctgg aggggtgagg ctgggagggg 168840 agggtatggt ggggtgggag aggccctggt cccccacccg cagaagagaa gcaggagccc 168900 tcgatgatca cagccctggg atagacacag tgcctcagcc aagggtcagg tacatgcccc 168960 tctggaggac aggctgtacc cctcggagac tcattgcatt ggcagctggt ctaggatgtg 169020 ggacagtctg cggtaaggtg agtggccggg gttttagtgt gtgagatgtg caacgccatt 169080 ttcacctgca tctgagtttc cagcagctcg cagggtaccg gccatattgt ttctctatct 169140 gggtgctgat ctcatggggt gtttgtcttg tgaccattca ctgggctgtc caggtgcaat 169200 ctgtgcacct ttctctgtgg ttctatgcct cacacagggt gtgcagggca cagcatccgc 169260 agggtgtcct gggcagagga gaggggcttc tggccgcacc aggggagaag gcacagggac 169320 ctctggcagc ccagccctca ggacacagtc aggccacgtg accttccccc caagtgaggc 169380 gcccctggac ccacagggtt gggtgtgggg ctgctctgac ggcagccagt cccacggggc 169440 ctctgagtca cagcctcagc ccacctgtgc cttggagtca ctcctgacag ccccacccac 169500 cagctctgtg tgataaggga caggtccctg ctccccggct ctgctgaggg aggcgcccca 169560 cccgagcctt cccctctgtc ctctacatga cacccctgcg gtggtaacct aactgtgtct 169620 taaaaacaag cacttgtccc ctttccaagt cctgggtcca cattcacgca tttgcctttc 169680 aaaggcacag ctgggctcta gtcctcgctc accacagagg aaacacaggg aagcccagag 169740 aagccaaggt cgcaccgtcg cccagcgaag gcagagctgg ggccaagccc tggccttcgc 169800 actccatgtg gccactttat ctctgcccag cacaggagct gcaaggaaaa gactccagga 169860 gaggagccct gaggggacag tgccccagcc cacccatgtc cagtgagtgg gcagggcagg 169920 tggggctgcg gaccccaggc tcaagacctt ctcaccagcc atcttcagag gagaagccag 169980 ccctgcctca ccgcaggact acgcgcttct gcccactatg caagtgtggc gaagcctgca 170040 gcagctgcag ccaggagctg atgggccggg gcagtgcccc attctcctgc gacagctgag 170100 ctcccacccc agattccctg ctcccaccag gggcttcccc acagcaagga ccaccttcct 170160 cctctgagcc agccaggcgg ccactggccc agtctggctg gggacagggc cctgggtggt 170220 ctctgtcccc accctgcctg ttccttctct tgggctgagc ccagtgctgg ggtcaaggat 170280 ggggaatggg tgctcttgaa ctgctgactc actgatccca atcaacagga gtttgcaggg 170340 gaaaggtgag cccttcccac ctggggaagg cgtgtcttac tctccaagta ggcatttcat 170400 ggcaccaggc agatgcttgg gcatttgcca tagtgtaact gttcagaaca gttgctctca 170460 gttgaacaaa tatttccaga gcatccactg aggggcagac caggtgttgg ggccaggatg 170520 agtaaaacac cattctccgt ctctgaggcc aggcgatctg gcaggctaga cagggctgaa 170580 cacaccttgg gtaccatgcg tgagggccac aggacgggag aggtcctgag ccagcaccag 170640 gcgcatgggt tagggtccag ccatcagctg gaagggtctc ctgtggaggt gataacaggg 170700 gcttgaagag tgagccaagg gggctggcac tagcaatgcc agagcaatga ggggcaggcc 170760 gtggggagac ggacgtagtt catcctgcca agagtgagct gcaggggcca gggtagatgt 170820 gggggagttg tgggcaaggt gggccaggac cttggggaga acccacagtc ctgtggaggc 170880 gctgtctggg agcccttggt gagggcggag ctgagcagga gcagggcttg cagaagagac 170940 ctggagggtg atgtcacagg agccagggag gaaggggact gggcttgaga ggcttgaggg 171000 catttgggag attccttggc aggggcttgg tgatggcttg ggcgtgggaa gtgaaggaga 171060 gggaggaacc tgggaagatc cccggcttct gggcgagggg gtggtggtga ttctgcctgc 171120 agagaagggg tggggagcct gggagggcct ggagggaggg aggagtccac agttcacact 171180 aggacgcctg ggttttccag tggctatctg acatccggga ggaggccaga gcccagcaca 171240 cggaggctct agagattcca agacgatgag gaggctggtc ctgagctgac ctgagcggaa 171300 ggggcctgag ggtgcagagg gaggacgggg ctgacagcag agtcctggga gcatctttag 171360 aggccgtgga ccacagccaa gccagtaggg agcccatcca gggaggcagt gggtacaaaa 171420 acagaagaaa gctgaaaaga gcaccctggg actccgatat tcaaggacca ttgttttaag 171480 gtttctgatc tccgcattca acagtgacaa gggcagcaga catcggtact ctcaggcatt 171540 tgtacagcac cttctgcact tcaaaatgcc ttccctgcac ccccaacaca gggcttgcaa 171600 atacaaagcc aggtgaggaa tggccctagg gcccccgtcc cagccctccc cagtttgcat 171660 tcatttggtt cctgagctag gacgctccct ccagctaccg gcatctggct gctgaggtgg 171720 gggccggggg cctgccagcc tgctgtgtcc ttgcccatca attttaccac ctgcgagacg 171780 ccaggagagg gcacatgaaa tataaaatga gttgaggcat aaaagtgttt cggaataaaa 171840 atgatgtgta ctggcaagag attacagtta ttacaaggac cgtgcgctgc cgccatcact 171900 catacctggg agaggaagag tgtggtcgcc tgccgaagga ggcagcagcc accgtgcctc 171960 ctcctctggg gacagggccg cagactgcag ggtgccaggc tgcaggatgg gctgaagcca 172020 gccctccggg agcatccagt gctctggggg atgaatgaca ctcccatgtc acagttaggc 172080 acaatgcagg gccgggcgcc gtggctcatg cctgtaatcc cagcactttg ggaggccgag 172140 gcgggtggat cacctgaggt caggagttca agaccggcct ggtcaacatg gcaaaactct 172200 gtctctacta aacacacaaa aattagctgg gcatggtggc aggcgcctgt aatcccagct 172260 acttgggagg ccgaggcagg agactcactt gaacctggga ggcagaggtt acagtgagct 172320 gagatcacgc cactgcactc cagccgggca tcacagtgag cctctgtctc aaaaacaaac 172380 aaacaacaaa caaaaactat taggcatggt gcaaatatgc tcctttttct gttacatttt 172440 ccaaggtgtc ttggacgttt accagacggc tttggcaggt ggcattcttt tttttttgag 172500 acgaagtctc actcttttcc cacaggctgg agtgcagtgg cgtgatcttg gctcactgca 172560 acctccacct cctgggttca agtgattctc ctgcctcagc ctcctgagta gctgggatta 172620 caggtgccca ccactgtacc aggcgaattt ttgtattttt agtacagacg gggtttcacc 172680 atgttagtca ggctggtttc aaactcctga cctcaggtga tccgcccacc ttggcctccc 172740 aaagtgctgg gattacaggc gtgagccacc gcgcccagcc ggcaggtggc attcttatgt 172800 ttgattctgc ccattctgca gaggagtcaa gcaaggctca ctgtatgtta gtgccttggc 172860 ctaagtagca atattaattc tagtactgcg agtctagcct tctgaattcc attcattcat 172920 tcattcattc attcgttcat tcattggatg aacattcttc caggcctact atgtgccagg 172980 aactctccca gatggtagag acacaaagat gtttccagct aattattatt attatttttt 173040 taagacaggg tctcactctg ttgtccaggc tggagtgcag tggcacaatc tcggttcact 173100 gcagccttga cctcctgggc tcaagcaatc ctcccacctc agccccctga gtagctggga 173160 ctacaggcgc atgccaccac acccagctag cttttgtatt ttttgtagag acagggtttt 173220 gctatgttgc ccaggctggt ctcgaactcc tgggctcatg tccctatttt tttttttaag 173280 ttgatggata gaattttctt ggttttaagt ttctctttca tgcactttta ttaaaacatt 173340 ggcatctgtt atccgtaact acattaagat ccctctaaga tagtatctgg ctgggcccag 173400 agtaccaaca ttgaatgacc tgtggtttcc tagggcagga tttcgtggga ttttgcagag 173460 agacccctca ccccggctct gggccaccct gaataacaat gtcaaaaacg atctggtggg 173520 caccctctgg agcagggtaa ggtgagttgg gagagaacat ggctctctgc agccagactc 173580 agtggctcac acctgtaatc ccagcacttt gggaggccga ggtaggcgga taatgaggtc 173640 aggagttcga gaccagcccg gccaatatgg tgaaacccca tctctactaa aaatacaaaa 173700 ttagccgggc ttggtggtgt gtgcctgtaa tcccagctac tcgggaggct gaggcaggag 173760 aatcacttga accagggagg cagaggttgc agtgagccaa gatcatgcca ctgcactcca 173820 gcctgggcaa caagaggaag actccgtctt aagaaaaaaa aatggctctg tctgcaagct 173880 caggtgtctc aacgtctggt tctaccacta ccggctgtgg ggctctgggc aagatgggaa 173940 cgtcacacca gatggcccgg ggaggcccca ggggagtacc ctgctcacag tgagcacaca 174000 ctccacggca gctgctgtta ctaggatgat gtgatgttgt tgtgttgttg gtaggactag 174060 gcccatccag ggagggtctc aaagctgggt ggggagagct ggcgtgccac ttggggagca 174120 aggagctccg tctctcagct gaggctggac gtctacctct ctgacactgc aggtgtgtgc 174180 gccccctccc tcctggggat atcatgagga tgaagcagaa gcacgcattg tgtgtgtgca 174240 tgtgcagggg gcagggtgaa gaaatcttac aattttaaac tgctcaggtg tctgggaagt 174300 aaagaaaaga aggaaggaat gaagccctcc ttttgggatg tcttggggtc acagagaccc 174360 ttttctggga agatttttca tttccccatc ttttttcatt tatttgagac agagtctcgc 174420 tctgtagccc aggctggagt gcagtggcac gagctcagct cactgcaacc tccacctccc 174480 aggttcaagc aattctcctg cctcagcctc ccaagtagct gggataacag gtgtgagcca 174540 ctatgcctgg ctaatttttg tatttttagt agagacaggg tttctccatg ttggccaggc 174600 taatctcaaa ctcctgacct caggtgatct gcctgcctcg gcctcccaaa gtgctgggat 174660 tacaggcgtg agctgcagcg cccggactcc gcacctattt tctgctctgc gtagggacag 174720 cctaatgcat tctgcagcag ggagccatgg caaattggta acaagccggc ccctggcctt 174780 catcccaccc ctccccgttc tcagacctgc cctgtcagct gacagtcctt tgagccagtc 174840 tcagctcaca gcttggcctt ggcagtgatc atcccaggct ctgagaaggg ctggcccctg 174900 ctagtctcgc aggaaggacc ctgctggctg tgtgtggtgt gcgccgcgct cactgacccc 174960 tccgggcccc ctccttccac ctcccttgct gcccttccga cgggtgagcg gggagagcaa 175020 ggcatgagcc cccagcgcgt tctagtcctt cctgcgtggc tgtttcctga gtgctgccca 175080 ctcagcatgc actacccccc caggccagga tgatgctggg cacaccaggg aagcagggag 175140 agaacctgtc cttgcctttg tgaaggggga atcgtcgtaa gcagggaatg attgcaacgt 175200 atgagagact gtggcatgga ttgtacctgt cacctctcgg cctcaccttt ctgagcctct 175260 gtcggccctc aggtctatgc agactgcgcc tctccctccc cctcaccagg cagccaagca 175320 gccccttgct tcttcgtctg ccctggggcc tcttggacct cacctgcagg acgtgctctg 175380 cacagtttcc tgcacacctg caagtgtgtg ggggcctatg cctgtgagcc acccttgagc 175440 aaaggtgtaa agaccgaagg acaaggcccc ccaggcccct gcaagtgggt ggttcatgag 175500 cttccttgga aggtcccaaa ggacggagct ccagccaccc cagcagtagc cagctccatg 175560 acccccgttc ccttccactc ctgtgtcact ccctatccct caggggaatg cagctaaagc 175620 agcagtgtct ggggagcacc cagcagggcc gtgactcagg ctggggatca gggagggact 175680 ccctgcagag gtgacattta agccaagctc tgaagcagga atgggagttg tccgggcaaa 175740 gaggcatcct gggtgaggaa agcagcctgt gcaaggcctc gaggtaggtg aagctgcttg 175800 ggagtagcaa cggcagggtg ggaggagtag gcagtggaga ggatggacac ggtggagggg 175860 agggatgtgg tggagaggga tggacacagt ggagaggagg tacatggtgg agaggatgga 175920 cgtggtggag gggagggacg cggtggagag gatggacgca gtggagagga gggacatggt 175980 ggagaggatg gacgtggtgg aggggaggga cgcggtggag agggatggac gtggtggagg 176040 ggagggacac agtggaaagg atggacacag tggagaggag ggacatggtg gagaggatgg 176100 acgtggtgga ggggagggac acagtggaaa ggatggacgc agtggagagg agggacatgg 176160 tggagaggat ggacgtggtg gaggggaggg acacggtgga gaggatggac gcagtggaga 176220 ggagggacat ggtggagagg atggacgtgg tggaggggag ggacgcggtg gagaggatgg 176280 acgcagtgga gaggaggtac atggtggaga ggatggacgt ggtggagggg agggacgcgg 176340 tggagaggat ggacgcagtg gagaggaggt acatggtgga gaggatggac gtggtggagg 176400 ggagggacgc ggtggagagg atggacgcag tggagaggag ggacatggtg gagaggatgg 176460 acgtggtgga ggggagggac gcggtggaga ggatggacgc agtggagagg agggacatgg 176520 tggagaggat ggacgtggtg gaggggaggg acgcggtgga gagggatgga cgtggtggag 176580 gggagggaca cagtggaaag gatggacaca gtggagagga gggacatggt ggagaggatg 176640 gacgtggtgg aggggaggga cacagtggaa aggatggacg cagtggagag gagggacatg 176700 gtggagagga tggacgtggt ggaggggagg gacacggtgg agaggatgga cgcagtggag 176760 aggagggaca tggtggagag gatggacgtg gtggagggga gggatgcggt ggagaggatg 176820 gacacagtgg aggggaggga agtggtggag aggagggacg tggtggaggg gagggatgtg 176880 gtggagagga tggacatggt ggaggggagg gaagtggtgg agaggatgga cgtggtggag 176940 gggagggaca cggtggagag ggatggacac agtggagagg agggacatgg tggagaggat 177000 ggacgtggtg gaggggaggg acacggtgga gaggatggac gcagtggaga ggagggacat 177060 ggtggagagg atggacgtgg tggaggggag ggacgcggtg gagaggatgg acacagtgga 177120 ggggagggaa gtggtggaga ggagggacgt ggtggagggg agggatgtgg tggagaggat 177180 ggacatggtg gaggggaggg aagtggtgga gaggatggac gtggtggagg ggagggacac 177240 ggtggagagg gatggacaca gtggagggga gggacgcagt ggagaggatg gacatggtgg 177300 aggggaggga tacggtggag gggagggagg agaggggagg gacgcggtgg agaggatgga 177360 cacagtggag gggagggaca cagtggagag gatggacacg gtggagggga gggaagtggt 177420 ggagaggagg gacgtggtgg aggggaggga tgtggcggag aggatggacg tggtggaggg 177480 gagggacacg gtggagaggg atggacacag tggaggggag ggacgcagtg gagaggatgg 177540 acatggtgga ggggagggat acggtggagg ggagggagga gaggggaggg acgcggtgga 177600 gaggatggac acagtggagg ggagggacgc ggtggagagg atggacacag tggaggggag 177660 ggaagtggtg gagaggaggg acgtggtgga ggggagggat gtggcggaga ggatggacgt 177720 ggtggagggg agggacacgg tggagaggga tggacacagt ggaggggagg gacgcagtgg 177780 agaggatgga catggtggag gggagggata cggtggaggg gagggaggag aggggaggga 177840 cgcggtggag aggatggaca cagtggaggg gagggacaca gtggagagga tggacacggt 177900 ggaggggagg gacgcggtgg aggggaggga cgcggtggag gggagggagg agaggggaag 177960 gatgcggtgg agaggaatgg atgtggtgga ggggaggaac gcattggaga agatggacac 178020 agtggagggg agggacgcag tggagagaga cggatgcatt agagagggat ggacgtggtg 178080 gagaagatga gcgtggtgga cagggatgga taagatgctc agcaatggac gcagtggtca 178140 tcggcgcctt cttggcaggc cacagggagg agtttagact gcgctagggc aagggggagc 178200 cacacaaggg tttggagcag gaactatttt ggccacttga tggagaccgg atgcagtgtt 178260 ggggccagag caggcaggga gacccattag gaggctgttc cggtgacccg gtaggacgac 178320 aagcaagaac aacagtgggg gtggggagaa tacccccaaa ttgtgccata gtcagcttca 178380 gcatctcatt ccgtgtgaat tacgaggctg gtcatggtga gtgtcggggc ctccatggat 178440 gctcggggtg atttctcatg gatcctgcaa ccacgtctcc ccttcacaag cctcttgcca 178500 agccctgctg gccctggtcc tctgtgttct tgctccttag gtcagtctca gacattcctg 178560 acacttgtgc ttcgtggccc tttcccagcc ctggctggca tctcgcgatg tagaagggag 178620 agaggccaga aggagagcag ctcagcccac gaggaggtgc ccatggaggc tggcaggggc 178680 ccaggggccc ccctgcactc tccccagttt tgagacctta gggcagtctc tcaccctcca 178740 gtcttggttt ctccacctct gaaagaatca cttttccttc ctgccaggaa ctgaagtcaa 178800 aggcacggca ttattgagac acattgggga gcagtgggcc cagcactggg acccatgctg 178860 ggtgtcccaa gagcacagaa tgttggcagg gaggggcggg ggccaggcag ggagctccct 178920 gctgctctac ggctgcccca cctgcagccc ttcccttcac cccacgcccc agtttcctct 178980 gctcttgggt ggccagtcac ccaggggtgg tatccaggga ggttcttgca ggcccagctt 179040 cactggcctg gaagggctaa gctacctggc ccaggggtgt gtccactttg tcctgggcag 179100 gctatgggca tcccacaggt ggagtcccat ggcagggctg gagccagggg gtaactcggc 179160 aggacagagg cccagccacc aggaagctcg cctgctgatg gccaagctca ggacaccttg 179220 caccactgta cctgaggaca ggctgtgact gatgacagtg gcttcatcct cagaggggaa 179280 gtgtcctgga gggatgtggc tggaggcacc cagccctgcg ggagcccctt tgaatgagca 179340 gatacctcgg gaagcagggt gaagggggca gaaactggga actctggatt tcaagacttg 179400 aaagaaaagt gctgcattgt gcggtggcat ctgcttgtgg ggacaagggc tccctggtga 179460 gacctctcca tcccctccct ccctccccct ctgtctcaca ctctttctct ctctccctgt 179520 cctcctatct cggcctcgca ctcgggtcgt gtttggtctg tgatgtcacc actcccctcc 179580 ctgtggctgc cattcagagc tggcagtaat gaaaagcaca ggattcccac tcactgggcc 179640 ccagcagcac tacagagaca tggagccctt tgttgcaaat aattaacttg gtcccatgtt 179700 gcataacatc ctaaaaagct ttcctgagcg agcacccgcc agacactgtg atctcatcaa 179760 tactgcatcg catcggacac tactgctgtg tgatttcatt aaaaatttaa tttgtgtttt 179820 aaatctgcag tgttcccttt aaaaggatgg cgagggcggg ggatgaagag agtgacaggc 179880 ttgggtctgg gggtgggcat tccaaagcag aggaaacccc acgccccaca ggaggtgggg 179940 gcggggcttc ccactggagc agcggcccct ctccgattgg ctgggcttgg tctgtggcct 180000 ctcctggtgc tggagggaga gtgatggacc attgatggaa aatgcttttc tgaagcttaa 180060 tggttttccc tttctctcgg ccacctcagg cagagggctg ctcctgggaa cccagacaca 180120 ggaggatggc caggtggtgg tgcaggtggt ggtgcaggtg gcggtgcagg tggcagggca 180180 ggtggcggtg caggtggcgg ggcaggtggt ggtgcaggtg gcggtgcagg tggtggggca 180240 gggcaggagt gccaggtggc agggcaggtg gcggtgcagg tggcggtgca tgtggtgggg 180300 caggtggtgg ggcagggcag gagtgccagg tggcagggca ggtggcggtg caggtggcgg 180360 gggcaggtgg cggtgcaggt ggcagggcag gtggtgcagg tggtggtgca ggtggcaggg 180420 caggtggcgg tgcaggtggc ggggcaggtg gcggtgcagg tggcggtgca ggtggtgggg 180480 caggtggtgg tgcaggtggc ggtgcaggtg gtggggcagg gcaggagggc caggtggtgg 180540 gcaggcggtg atgcaggtgg tggtgcaggt ggtggtgcag gtggcagtgc aggtggtggg 180600 gcagggcagg agggccaggt ggtggtgcag gtggcagtgc aggacgtgtt ttccggagac 180660 cccgtcctct gtgcccctcc agacccagtg cctacagtgg tcaagaccag agctgcagcc 180720 tcactcctgc cctcctggct gtgtgacctc aggcaagctg cttgtcctct ctgagtacag 180780 atcactgccc ggagtgtgag tgggggcctt gcctgtcccc agctccaggt tgctgacagg 180840 agagtgtgag tgaagggcct tgcctgtccc cagctccagg tcagcacccg cagtgtcact 180900 ctcacccccg tgtggctatg gagcaggcag ccattggtga ctgggtagca gaccctccgg 180960 aaaggctgcg gttctgtttt ctttctttgt ctagacttca ctctcttcca gagaggattt 181020 aagctggcct tcatcatcgg tgctgcctgc agacccgtcc ctgggatttc gctgcgaatg 181080 ggatcctgtt gtttctagac agggacctcc attgtgttgg ggggggattg gtttcactcc 181140 tgtttccagt gagcggggag ggaaagagag ctcaggttct ggttggggga ggagagagag 181200 gaaggtgagg ggagcacgga gaaggagact ctggggcaac ttcgtgatgc tgcctgcctg 181260 gctctgcctg gggactcttt ggtcccgccc gccctggcca ggccaattgt ttcctgcgga 181320 aggcagggat ttgtgcatct ccaactatct cctgacagta tgccagagtg attaagctaa 181380 gcctcccggg gccagcagaa gagaggggac aaattgcttt gtgaaattga tttgctgctg 181440 ttagcattta cagcttgccc tgggtacgcc cacagtgtga ggcggctgcg tgggcgtcct 181500 gctccccctt ccctctcccg cagcacacgg gctctcactt ggcacctgcg cacacatcac 181560 ctgtcgtgtg tcacatagcc aggcctcagg acctggactt cagtaccact cacctcaggg 181620 cacaggtcca aagtgtccca aatgcccatg gaggcagacg gccacccaca gctgcagcct 181680 gcagagagaa ttgccccaga gactcttgga taggtgggtt tccccaggcc agcgtgagag 181740 ctggggccac gagatctgag aggacacctg gaggcccaga gaggaggcgt gagctagccc 181800 tgggccaggg tctccccatc tctttttttt aaatttgttt tgttttagac tgagtcccaa 181860 tctgtggccc aggctggagt tcagtggcgt gatctcggct cactgcaacc tcctgcctca 181920 gcctcccgag tagctcggat tacaggcgca tgccaccatg cccggctaat ttttgcattt 181980 ttagtaaaca ctaaaaatga tttcatcatg ttggccaggc tggtctcgaa ctcctgacct 182040 caagtgatcc gcccgtctca gcctcccaaa gtgctgggat tacaggcgtg agccactgtg 182100 tccggcctct ccccacctct tggggggccc cttctgccac accggctgcc ctcctccatt 182160 ccaggggaag gaagacaagg agaatattgc cctggtcagc aacagttctc atagaagctg 182220 tatgaactca ggtgagcgtc atgaacccac acgcctgggt gctggggcca ttcagagaag 182280 aggcggtgct gggactggtg gatccttcca gacagagaaa tgtggctgag catcaccacc 182340 caggaaatag aaagcactga caattcgccc aggtgggtcc cactatgcat ttcaagaaat 182400 gcgtgcttgg taacggaggc agcatggcct cggtgcaccc caggagatgg gagactcagg 182460 ctacgggcgc tgctgggtat agtagcctgc tttcaggctc tccttgggca ccagctctga 182520 gcaggctcta ggcatgacta gatggtggga agggggtcca gggagccatg agaggagcag 182580 cctcagcgtc tctcctgggc tggagccagg tccatcgctc agctgctgtg taacctcaga 182640 caggtgactt cacctctctg ggctgtggta agggttacat tagacaaacc ccacaaggct 182700 cttagaacag tgccggttgg taggcggggc acggtgactc acacctgaaa tcccagcact 182760 ctgggaggcc aaggtaggcg gatcacctga ggtcaggagt tcaagaccag cctggccaac 182820 atggtgaaac cccttctcta caaaaatcag ccgggagtgg tggcacacac ctgtaatctc 182880 agctactcag gaggctgagg caggagaatc acttgaacct gggaggtgga ggttgcagtg 182940 agctgagatc acgccattgc actccagcct gggcaacaga gcacggactc cgtctcaaaa 183000 aaaaaaagaa cagtgctggt cagtggaagc atttggcaaa tcctagttgt gactgttgct 183060 gttttcccct cccttgagat gctcagatgt ttgtcatcat acaaggacgt gagggtgggg 183120 cacaccagca gtgcttctga ggttaggggg ctcttcagtc ccaggccagg gggaaggaag 183180 gaaagtgggt ctctcagcag caccacagac tggaccctag cacagcaggc acgtcccttt 183240 aaaaatttaa attaaaaata tttaaatggg ggtaaaatat acataacata aaatgtacca 183300 tgttaactgt ttttgagtgg agcgttcagt ggcattaagc acattcacgt gattgtggga 183360 ccatcaccat gagtccccag aactcttttc atcctcccaa actgaactcc gtctccatta 183420 aataccaact ccccattcgc cctcccccag gcctgggcac ccccccattc tacctctgtt 183480 ccagttaaac cagtgcccag cgagactcat gtaagtggaa tgatacagtg tttggcccag 183540 gaagccttgt gtaagtggaa tgatacagtt ttgacccaag gaggctggtg tagcttctac 183600 ctttcctcta taatgaataa gactgctgtg aacacgggtg tagaaatagc tcttcaagac 183660 catgctttta cttcttgtag atgtgtaccc aaaagtggaa ttgctggatc atatacctcc 183720 cttttaaaac aaatgcagaa actgaggcta tacagaaggg ctcagaggtt tgccgagggt 183780 cccagccacc tcagtggcgg agcaggcagc atttccccac cccaactctg tgggtcgctg 183840 gcactatgct ctccctcccc agcgtctgtg tggcctgttt tattcccagg ctttatagaa 183900 ggctctctgg aagacatgag ctgtgatgga tgcaccaaag gagggtcatc accattcctt 183960 cttttttttt tttttttttt ttctggagac aaagtctcac tctgtcaccc aggctggagt 184020 gcagtggcgt gatctcagct cactgcaacc tccgcctcct gggttcaagt gattctcctg 184080 ccttggcctc ctgagtagct gggattacag gcacccacca ccacgctcag ctaatttttt 184140 gtatttttag tagagatggg gtttcaccat gttggtcagg ctggtctcga actcctgacc 184200 tcaaatgatc cacccatctt gtctttccaa agtgctagga ctacaggcat gagccaccat 184260 gcccagctga gtgtcatcac cattctgaac tagttttact cacactctga caccaaatgt 184320 gtgagggttt tttttttttt tcctacatcg accagttctt caactttcca gacagctggg 184380 tggcctacaa ctcacttcaa ttcttacact gactacctgt agttagcaca gacctcacat 184440 ttaagggtca gtcccacaag attgccccct ccttcagaca ccaatgacaa gtcccaggtt 184500 gtcaccagtt cttctggttg actggctata aatcagggtt cccataaccc ccatctcagg 184560 ttcaacagtt tactagaatg actcacagag ctcaagaaag tgctttactt actattgctg 184620 gtttattata agggctacaa ctcagaaaca gccacaaaga agagatgcat aggacaagat 184680 acgggggaag aggcaccaag cttccatgcc ctccccagca ccttgacctg ttccccaacc 184740 cagaagctct ttgaacccca tgtttagggc tttttacgga ggctgcatca cacagtcgtg 184800 cttgattaaa tcatccgcag ttggtgatca actcaatctc cagcccctcg cccctgtcca 184860 gagctcattg aatcgggagc cttaagaacc ccccaccccc agttgctctt tctcttccct 184920 ctggcatggt ggctagatcc ctaggtgatg aagtggaagg aggcctcctg ctgatccacg 184980 atgaacctac tgtgggaaag aaccagaaag aacagctgcc gcttagagca ggtggtatct 185040 caagcctgtg tgttactgca gcaaaaccta tggccgcctg ggtcctgacc acctgagggg 185100 tacagtgttc tcaggggcgc atttctgcct tcacgtccct gagcctgggg aagtcctgcc 185160 caaactcggt tctcctggag tctctttcat ctttgaggca accactacct ttccgtcaac 185220 tccctcttct gcttcagtta accacaggta ggttttgctc cttgcaactg acaacctggg 185280 ctgatggagg aagctgtttc agctgttatc aagcaacacc tcgagcaggt gagtctgtag 185340 ctggaggcct ccaaggtgct ggtgtctgaa gcaaagatag gtcactggaa aaagaggtgg 185400 cgtgtgtgtg tgtgtgttta gaaacagagt gtagttgtgt gtctgtgcat gtagaaagag 185460 gacatggttg tgtgtgtgtg tttgtgtgtg cgtgtataga aagaggatgt ggggccaggc 185520 acagtggctc atgcctgtaa tcctagtgta taattgggag gctgaggtgg acagactgct 185580 tgagcccagg agttcaagac cagcctaggc aacatatcga gagtctgtct ctacaacaaa 185640 aaataaaaaa ttagctgggc atggtgatgc atgcctatag tcccagttac tcaggagact 185700 gaggcaggag gatcacttga gacaggaagg ttgaagctgc agtgagctat gatcacgaca 185760 ctgcactggg taacagtaaa actccgtctc aaaaaaaaaa agtgtttttt tgtgtttgtg 185820 agcatgtgtg tgagtgtata ggaagaggat gtggtcatgt gagtgtgcct gtgagtaatg 185880 tatatgtgag tatacctgtg tgtgtgtgtt gtgtgtatat gtgagtgtgc ctgtgtgtgt 185940 gtgttgtgtg tatatgtatg tgttgtatgt atatgtgagt gtgcctctgt gtgtgtgttg 186000 tgtatatgtg agtgtgtgtg ttgtgtgtat atgtgtgtgt tgtgtgtata tgtgagtgtg 186060 tgctggggca gcatcacagg aattcgcctg ccataaggcc gggctgcgtc acggctaagg 186120 ccgcagttcc cccaccgtgc ctgggtttgg atcctggctg ctccggtcgc ctgctgtggg 186180 tccttgcaca cattaacctc tgaacaccag tggccgtatc tgaaatagcg cgagaacaaa 186240 actcaggatt gctggggagc tgtaggagtg gaattatgca aagcatggca tgtcgcccgt 186300 aacagacttc cgggccaccg tggtggtgcc gacacaggcc ggccggggcg tgcgtggggt 186360 ctggctttgt cttcttgtct ccctctgctc ctccctcctc ccctggccga gggagcccgg 186420 cctgtcttcc tggccacagt tcgggaggcc gccgtcctca aagctgggca ccagctatgg 186480 ctcagtgtct ccagcctcca ggattcctgt ggtcgggatc cagcgtctct ttatcgtttt 186540 taaagtgttt tgctgctggg aagcctcaag cctctccgca gagggacata aataaaggca 186600 ggaacttggc cattagtagg cttcatgtgg cgtttccacc tgggagcgcc ctggcgtgct 186660 gcaagctgcc ctcactggcc aagagcaggg cgggagggga gcctctggag ttctccggtt 186720 ctgggttagg tgcctcttac tctctgggct gcaaacagac gggggtgcct ggcaatgtgc 186780 cccgggcgga gcacccctaa cagttgcagt tcaaatttgg agccaggctg accctggttc 186840 aagtcctgtt gctgtgtgct ggccgtgtcc ctggacgggt ggcacaaggt cttggtctcc 186900 agtgtgcaga tgagagatgg tgattatcta ctcctgggtg ctgggctcag agccgctggc 186960 accagccctg ggggctgcca gacatatagc cctcggctct gtcacgcccg gaactcaaac 187020 ctcgcaggca gtcaggggag aggtctgtgt gtggagctca gaactcagtg agcaccccat 187080 gtgcctgtaa ggcctcgcca tctcctaccc aacccagatg aggctcctgc ttcccacccc 187140 tggcagggag tctgatctca tcctagctca aaggtggaaa ctgaacgtgg gccaggtggc 187200 aaagttcccc agtgggttca gcttccgccg ggtggaggag gtgggaggca tggctggagg 187260 cctggcatca ggctggatga ggtggacccc tcaggcttga atccaagagg gctcagaggg 187320 tgagtggggc cccaggccac gtctccaaca gctgcccacc tagccttgcg cctccgcctt 187380 ccttccttcc tttaaaaatg gctacaggca cattttcttt gattactttt atactgaata 187440 acactatcct ttttaaagca aaaaatacat gctcatgata aacaaatgga accggacaga 187500 tctttatcaa ggcccccgca atgtgacctt gtgactccaa gacagaataa ctttccatgt 187560 gtgttttcaa gaggttgtgg ggagccgctg aacctgggag cagtgagggc acaggcgaga 187620 gctgtggcca ggagagtcac aggagcggca aagacgaaag ggagtgggag atgggaggcc 187680 aatcagaaag cagtgcccga agctgggtga ggagcagcaa aggcgggggt ttccttgagg 187740 atacctgaga gccatgctag ggtggggagg tctgggggga gttgtgggct ggccttgagt 187800 ttgagattga ggcccaggct gagagcgtgg tgacccctgc actgtgggtc tgctcgagct 187860 gtgtgcttcc caggagcaag agcaaagagg ccagagggag gggggcagaa caggccagca 187920 agggagcccc cagaacagga cacgcgttcc ttggccctcc ccaggcagcc ctaagaggga 187980 agagaagctc tgccccctcc tgccccctcc tgccctctcc tgttccctcc tgccccctcc 188040 tgctctcctc catggagtca gggggcccca ggtggccatg gccagcccat tcagggatct 188100 gagccccaga gcctgcatgc cagggtgagc agagccagct tgactgcagc catgctgacc 188160 ccgcaacctt ccccgaggtc tgaggacacc acgctccctt cctgccggca ggttgtaatt 188220 gggtttcaca cggggccttc tggcgctgac ctacatgttc cggtccgtgc ctccttggtt 188280 tctgagtgtg tgcccctgat ggttctggaa cctctgggcg tgggcctcct tccctccccg 188340 cctcatcagc tgctctgatt ccaccgggca aggtcaggct ggcaaggaag gaattggagc 188400 tgcagtctgg gcgccaggcc cagagtgtgc ttcccagggg ctgcctgtgg ggaggctccc 188460 gatctgccca ctcccgaaat aagaaggggc gcccagagag gaggagactc tggatgcgtg 188520 gtcagcaggc accggctgcc atccccagga gagtcattgc ctgtgaggac gttgaccctg 188580 gtaggacccg cctctctgaa gctgtctcgg gtgtgagtga ggaggaacgg ggtctctggg 188640 gactgagccc tcatctccag tgcaaaatgc agaggcatgg gagggaatca aatgaaacag 188700 tgtgtgtgga acagaaggcg ccaaatggga atgtccccct gcctgtccat ctccctccct 188760 cccccgcctc cttatttgca gacggaggga ctggatatcc tggcagagcg tcttccgtga 188820 tgcgtaacct cccaggagat gcatgttctg gggttcccca cttacagttg agaatacaga 188880 ggctaagaag ggtgaaggga ctgcctccgg gtcccaaggc tgttccaagt gatctaggac 188940 tcagctttgg tcctcctgcc ctcagcaccc ttggtcatca cctccactcg gtgtgcagga 189000 ggctcctgct gtaggtgccc agatgttcgg cagctttgta cttagaaatt tcgagggggc 189060 ggtcgggcgc tgtgtctcac gcctgtaatc ccagcacttt gggaggccga ggcaggtgga 189120 tcacaaggtc aggagatcga gaccatcctg gttaacacag tgaaaccccg tctctactaa 189180 agatacaaaa aaatagccgg gtgtggtggt gggcgcctgt agtcccagct actcgggagg 189240 ctgaggcagg agaatggtgt gaacccggga ggcggagctt gcagctagcc gagatcacgc 189300 actgcactcc agcctgggtg acagagcaag actccctctc aaaaaaaaaa caaacacaca 189360 gaaatttcga gggggcagag ggtgtcctaa ccttgtccct cagcaggtct tcaccctggc 189420 accttcacca gacacccgcc atggctctcg gctcagcggg tagctgagtg tgttctcttt 189480 gggttctgac aggttccagc ttgttttttg agaccttgtc agcgtggggc ctgccgggaa 189540 gcaggtgctt gtctttaatg ggatgcctta tcctgggctc cacaggctgc acggggcgtt 189600 gttcaggtga ctcctacacg ccgaggcgtc tctagaggag gagcctcaaa aggactagca 189660 gggggtgcag ataactttgt ttttaaaatg aagccaaagc tttcaccaca tctcagagac 189720 agagtgaccc gaatgtggag gtttggctgg aaccaggcag gtaccatcca ctacggctcc 189780 cacctctcct gctcggaatc ccccgctgcc ctcccccagg ccctggtctc tgatttcaga 189840 ctcgcctctg ctctgtttca cgtctcctgc aagcagacaa gcatgaagcc tgccctccga 189900 ggctgcatga ataatagaac tgaaatcatc cctagttaaa aatagatact cttcttaata 189960 aatattttac atactgtctt taggatatac aggtcccctg gctgaagact taaagcaaac 190020 cctgttatcg aaaccaaaag atgtaggaaa ggctctgccc gggctctgcc agtgtgttcc 190080 tgcaccacgg ctcttgcctc aaagccaccc actctgcggt gacgtccgac gcagacagcg 190140 cacacacgga ttacgttgga actcatagcc aggagcggct tgggaattct tgggtgtatt 190200 agtcacttgt gaattttatg gaggcaaatc aattataaag tgccccttgg ttagtgaggc 190260 ttggagttca gaaaacccaa aagcaggttc ttacgttact gctgcgaggc aaggccttca 190320 ccgtgaatgg aagctggggt gtctgggggc agctgtgtgg aggaagagaa aattctgggc 190380 agaagcagtt ggagtttaaa gtgctggccc atttctgaaa actttgcaaa ctttgcaaaa 190440 actttggatc ggacgtcact gcagagtggg tggctttgag gcaaacagag caatcttgaa 190500 ggtctccatt aatgaaggca tggcgtggtc tggatgcagc aaatgcattt gaatgatctg 190560 caggaaggcc tcgtagcctt gctcccccca cccatgtgct tccccaggaa gacaggggca 190620 gctaggaaat gctggggcct gcccagtgtg cagaccgctt ccaggtgacc ccacgctgca 190680 tggcccaagg caaaggctgg agcgtcctta tttaacagga gaggaaagtg gatactggaa 190740 gggcagagcg tgctggggct ggaacagaca agccccaggc tggagggccc atgtctcact 190800 ccctctgccc cacacctcag ctggtctgcc tatgtggtat tcttgaactg agtgaagaga 190860 cccttctctg tcagggccac ctgccccaca gaggggctct tgtcttcctt gtgctcaaca 190920 taccttgagg acattttgct ttagcaccca gcaccctgga tggcatgtag gggtccaggt 190980 gtgtctctgc tccagacagt gaatccttga gcacctggct tagagctggg cccctggtac 191040 atgttgttac atggatgggt gggtaggtgg atgggtgggt gggtaggtgg atgggtaggt 191100 gggtgatatg atttggcttt gtgtccccac ccaaatctca tcttgaattg taatccccat 191160 aatccccacg tgtgaaggga gggacctggt aggaggtgat tggattatgg ggggtggatg 191220 ggtggatgtg tggatggagg gatgggtgga tagatggagg gatggagggg tggatgaata 191280 gtgtgtatgg ataagtggat ggagggatgg gtggatgggt agatggaggg atgggtggag 191340 gggtagaggg gtggatggac ggatggatgg gagcatgtat ggataagtgg atggagggat 191400 gggtggaggg gtagaggggt ggatggacgg atggatggga gcatgtatgg ataagtggat 191460 ggagggatgg gtagataggt ggatggaggg atgggtggat agggggatgg agggatgggt 191520 ggatgggtgg atacatggat ggagggatgg tggataggtg gatggatgga tagagggagg 191580 ggtgggtgga tgatggagag agggatgagt ggatggatgg atgagtagat gaacagatgt 191640 gtggataaag ggatgggtga atgggtggat ggagggatgg gtagatgggt agatggaagg 191700 atggatggag gggtggaggg gtgggtggat ggatggatgg attgttgtgt gtatagataa 191760 gtggatggag ggatgggtag atgggtggat gtgtggatgg aggatggtgg ataggtagac 191820 ggatggatag agggaggggt ggagggatga tggagagagg aatgagtgga tggatggatg 191880 agtggatgaa tagatgggtg gataagggga tgggtggatg gagggatggg tggatgggta 191940 gatggaagga tggatggagg catggaggtg tgggtgggtg ggtggatggg tgtgtgtatg 192000 gataagtgga tggagggatg ggtggatagg tggatggagg gatgagtgga tgggtggatg 192060 tgtggatgga gggatggtgg ataggtggat agagggagga gtggatggat gatggagaga 192120 gggatgaatg gatggatgga tgaatggatg aatatatggg tggatgaagg gatgggtgaa 192180 tgggtggatg aatggaggga tgggtggatg gagggatgat ggatggtagg ggtagatggg 192240 tggatggagg gatgggtgaa tgtattgatg gtagggtgaa tgaagggatg ggtggataga 192300 tggctgggtg gaaggatggg tggattggtg gatagatagg tgaatggatt gagggatggg 192360 cggatgatgg atggtggatg gatgggtggg taggtggatc catggatgga tgcacagagg 192420 gaaaaaggca cattgtatca gactccaaag ggagaattaa ttgcagcata aaatgggagt 192480 ccaggacctc tcttatttca gagttcatcg tgtagatggg aacagtgttt aacccttccc 192540 tctcccactg ccctctgtca gctgcttccc agttcctaaa ttattggctc tgaaagtggg 192600 ggctggggga gtggggaaaa gagtggagat gctgagactt tcccatgtgt ccagcttcca 192660 gaggcttcca ggacagactg tggcaccatg gttagtagcc aggagcaggt tagggcatta 192720 tggtacctcc ccaaacaaag cagggtgctc cagcttcagg cagtcaggac cccatctgct 192780 cagtgagtgt ctggtcagca cccactcagg ccaggctgtg tggcaaatac aaaagaagtt 192840 aaaaaaaaat aaagacattc cattatttca atagaaagaa ttttttaaaa atgtgtcact 192900 ggaggtacac ttgctttaca ttttttgctt tggaagatgt agggaaaaaa gtcatgaaat 192960 gttttcattt ctctgtgatt gagcagactc ttaaaatatt aaactattgc ttaataattg 193020 attaaaacta atctctgtgg gagccaacca cccatttggt aggatctctt taaactttta 193080 ggggctttta gctccccctg gccgcctaac ctttctcttg tctgattcat tctgggctca 193140 gcagacgttt ggtctcttgt ggattgatga tgtcaggatg cttctgtcgg gccgtgggat 193200 ggctgatgag gctggattcc gaacaaggaa catcctaggg acacagtgtc tggagaggca 193260 gtgagggaag aggaaagaaa tgtctgtgaa taattgtact gcagcttcta aaactcggga 193320 cgggagtcag agaaaacagc cctgtggcct tcagagccgc ttaagttgtc tgtgacttga 193380 gtttttccac acaatgacaa tggtgcctgc ctctccattt tcccaggaac gctaagccat 193440 cgagcaaagt ggtttagaat gtgggcgcag gcatccgagt gtctggcttc aaaacttccc 193500 cagcaagtta ccgaatgtgt aaccttggac gcgcttttta ttttctctat acctcagctc 193560 cttatcaata aaatgaggat agtaatatta atagaaaccc tcttctgtgc agatgaggtg 193620 aggcaatgca tgtaaagttc ttagcactgg ccagggctgg gcaaaggcag ggctcactat 193680 gcatttaaga gctcaaagcc cgggtgagct ggctcacgcc tgtaatccca gcactttggg 193740 aggccgaggc gggcggatca cctgaggtcg ggagttcaag accagcctgg ccaacatgca 193800 gaagccctgt ctctactaaa aatacaaaaa aattagccgg gtggggtggc acacgcctga 193860 aatcccagct actccggagg ctgaggcagg agaatcgctt gaacccggga agcagaggtt 193920 gcggtgagcc cagatcacgc cattgcactc cagcctgggc aacaagagtg aaactctgtc 193980 tcaaaaaaag aaagaaagaa aaaagcccaa aggagactct gaattttaaa acaactactt 194040 tgaggccagt cacggtggtt cacgcctgta atcccagcac ttcgggaggc caaggcagga 194100 ggatcacttg ggccccaggg ttcgagacca gcctagacaa catggtgaga ccccacctct 194160 acaaaaaatg tagaaattaa ctgggtgtgg tggaacatgc ctgtagcccc agctactcag 194220 gaggctgagg tgggaggatt gcttgagcca gggagttcga agctgcaatg agcgatgatc 194280 atatcactgc actccagcct ggtgacagag ggagaccctg tcttgaaaaa ataaataaaa 194340 caaaaacaac tactttgaaa aagggatcat taggtgaaca actgaagcct ctgaaactaa 194400 acagtctcag ccaggtgcgg tggctcacac ctgtaatccc agcactttgg gagtccgagg 194460 cgggtggatc acctgaggtc aggagtttga gactagcctg gccaacatgg tgaaaccccg 194520 tctctactaa aaatataaaa aattggccgg gtgtggtagc tcacgcctgt aatcccacca 194580 cttcgggtgg atcacctgaa gtcaggagtt tgagaccagc ctggccaaca tggcaaaacc 194640 ctatctctac taaaaataca aaaattagcc aggtgtggtt gtgcatccct gtaatcccag 194700 ctacttgaga ggctgaggaa ggagaatcgc ttgaacctgg gaggcagagg ttacagtgag 194760 ccaagatggc accactgtac tccagcctgg gcgacaggag caaaactcca tctcaaaaaa 194820 gaaaagaaaa gaaacgaagc agtctcaaag aaatgtttgt acacttgtgt ttatagcagc 194880 actattcaca acagccaaaa tgtggaaaca acccagatgt ccatgggcgc atgaatgggt 194940 aaagcaatgt ggtatgtacg tacaacgggg tattatttag ccctgaaaaa ggaagaaaat 195000 tcagaggtcg ggtgcagtgg ctcacaactg tacctataac cccagaactt tgggaggccg 195060 aggcaggagg attgcttgag cccaggagtt caagaccagc ctgggcaaca tggtgagatc 195120 ctgtctctat acaaaaaaac aaaaaaaatc agccagatgt ggtggcacat gccagtggtt 195180 ccagctactt gagaggctga ggtgggagga ttggttgagc ccaggagttg aggctgcagt 195240 gagctgtgat cataccactg cactccagcc tgggcaagag agcaggaaaa cgcctccccc 195300 agcatacaca aaggaaggaa attctgactc gtgctacaac atggatgaat ctcaagacat 195360 gctaagtgaa ataagccagt cgctggccgg gggtggtagc tcatacctgt aattccaaca 195420 ctctgggagg ctgaggcagg cagatcactt gaggtcagga tttcaagacc agcctgggca 195480 acatggtgaa accctgtctc caccaaaaaa tacaaaaaca aacaaaacaa acaaaacaat 195540 tagccagatt tggtagcaca tgcctgtagt cccagctact caggaggctg atgcatgaga 195600 atcacttgaa ccctggaggc ggaggcaaca gtgaaccgag attgtgccac tgcactccag 195660 cctgggcaac acagaccccg tctgaaataa ataaataaat aataaggcag tcacaaaggg 195720 gcaaatactg tataattcca cgtctatgag gtatttattt tattattgtt attatttttg 195780 agatggagtc tcgctctgtt gcccaggcta gagtgcagtg gtgcaatctt ggctgactgc 195840 aacctctgcc tcctgggttc aagcgattct cctgcctcag cctcctgagt agctgggatt 195900 acagtagcct gccaccacac ccagctaatt tttgtatttt tagtaaagac agggtttcac 195960 cacattggcc aggctggtct tgaactcttg atctcaggtg agccacccgc cttggcgtcc 196020 caaagtgctg ggattacagg catgagccac catgcctggc cctatgatgt atttagagca 196080 gccagaaaaa tagagataga aagtggaatg gaggttgcca gggctgggga ggggaatgtg 196140 gagttgtcat ttaatgggtg cagagtttca gttttgtaag atgaaaagag ttctggaaat 196200 gaatggtggt gatggttgca taacaacgta aattaactta atgccactga actgtgcact 196260 caaaaatggt aatgatgata actttatgtg tagcttacca caattcaaaa taataaaagg 196320 atgggtgagg tagctcacgc ctgtgatccc agcactttgg gaggccaagg tgggtggatc 196380 acttgaggtc aggagtttga gaccagcctg gccaacatgg tgaaaccccg tctctactaa 196440 aaatacaaaa attagccagg cgtggtggcg ggtgcctgaa atcccagcta cttgagaggc 196500 tgaggcagga gactcacttg aacctgagag gcagagattg cagtgagctg agatcgtgcc 196560 actgcattcc agcctcggca acagagcgag actccatcat cctaggcctt gcacagatga 196620 ggtggggcct ttgattaaga gctcagcggg gaccaccatg ccccctcccc acctgccccg 196680 agacatcctc agaccagcct caaaggccca cagctggatt ggccagcctc aactttgcat 196740 gctgtcggtg ggcgtggaaa tggatccagc ctccttgaag gtgccactca ggaggatgtc 196800 caggaaatct taaacgtgag tgaaggcaag agctcctgag tggtgggttg ggatctgaac 196860 acagccccac ctggttctag cacagccctg gtcctcattc ttcttggtcc agccaggcac 196920 cgtgggctac atcatcctaa gaaaggggaa taaaaccaga gagggtagag tcagggcctg 196980 gatccaccct gattaatctc ccatccagag aatacgaaag gcaatgccag gaagatgttc 197040 taaggtcaaa tgaaccatct atgaactcac gcttccttct acagagcctg tggcttacaa 197100 agcactttgg ctgggcgtat ctcttccatt tccctggagc tgccctgacc tggggaacac 197160 caacctcgtc tccctctcta cagacttctc cacttaaaat ggccaagaca ggggctgcct 197220 tttctggggg ttctggggta ttcctggggg agatcaaggc tgggggcagg ttgatggtgg 197280 aggtgcaggg tgccctgaac tgggagtcac actgtaggct ccgcagcagc cggaagaggg 197340 ctcaaaatac aataaggata aataaaactc aggcttcctt tctctctctg tctctttttt 197400 tgagacgggg tcttgctctg ttgcccaggc tggagtgcag tggcacaatc ttggcttgct 197460 gcggccttga cctcccattc tcaagcgatc ctctcacccc agcctcccga gtagctggaa 197520 ccacagcaca tgccaccaca ccttgctaat ttttttctat tttttgtaga gatgggggtc 197580 tcaccatgtt gcccaggctg gtcttgaact cctggcctca agctatcgtc ctgccctggc 197640 atcccaaagt gctgtggcgt gagccacact gcacttggca gccttcgttt ttttctttcc 197700 tctttttatc agaccaatac aggcaggtga tttttttaaa agtcagattt ttaaaaaacc 197760 tgacagtaca aagaggttta taaagaaaag gattccctcc tgctccgcct ttctcatccc 197820 cggagataac ctcttttgac ggtttccgtt ttaaatcatg atggtggtca cctcctcagg 197880 tccaaataat atggctacag tgctgttgct tgatttatgg accttagaaa tggcccaccg 197940 atttcccgct gcgatcgatg aggactcagc tcgtcggcac tgccactccc agccccagtt 198000 cagtttccga gtctacctct agttcgtctg ctgcttactt gctaacttgg aattccatct 198060 gagacccagc ctgaggccgt cacctgtggg cagcgtctgc tctcctcctt ggggatggag 198120 ggtaccaccc ttcctggacc ctcccatggt ttcctcagct cctgtctgct tttctctgcc 198180 aaagttggaa gttctctcat cctgctctgc agggcagctg cctccatgcc tggtgggcag 198240 agcgggtctt tcactccaca gcgtgcgctg aagtgttcgc agcgggtcct gcacggccag 198300 gcatgtcctc cccacgttcc cagctgcgca ctggacacac ccaagtcaca ctggaccctt 198360 cctgatgcgc caccgccacg gagggtccaa accacttccg gctttagatg gctttctgct 198420 tggcccacgc cttcctcatg ctcaccccac tttgtgggga gtagcagctg tggccctaat 198480 gtgccccgtg ccaccctgac tttaggtcgt ggactctgtc caggcttctc ctcaaagttc 198540 acatcagcat cttcatatct ggaccaaaac tttctggcgc agacttttgt tgtttctggg 198600 tttctaatgg cctttttttt ttttggcgct gcctcgttgg ttgtgccctg gagtcctgtc 198660 gcctcgtgta cttcagcctt cgggttgagg ctgaggttcc tgttggactg ggggtgactt 198720 ttgtctgccc acgtgggtgg caagtgagga gcagcatggg gttggctctg gccagagccg 198780 agatcttcag ggcagtggcc aagccctggg tgcaggggcc gcccatgcca ccaacctgac 198840 acctccactt ccagaagggg aagctggtcc gagttttatg gccgttggct gtcgaaactg 198900 gacccacaga gccaagaccc tgtgctgcgc ccgctgcacc ctgagctgtc cagaggccca 198960 gcccctccct acactgtgtc ctccatggcc cagaaagcac ttatgcacat gctcacacaa 199020 cacacacacc acactcaatc cacacacatc acacactaca ctcaatccat acacaccaca 199080 cagcacacac caatccacat acatacacca cgctcaatcc acacacacta tacagcacac 199140 gccacactca accacacctc ccccacacac accacacaca acactcatac ctcacatcac 199200 acaacacgct caatccacac accacacaca ctcacaccat gctcaatcca cacacgccac 199260 acacaacact cataccacac atcacacacc acactcaatc cacacacacc acacatcaca 199320 cactatactc aatccacaca cactacacag tacacaccat gctcaatcca cacaccatat 199380 gcacatcaca ctcaatccac cttcaatcca cacacaccac ataccacact caaatccaca 199440 tacttacacc acactcaatc cacacacacc acacacactc ataccaccct cagccacaca 199500 caccacactc aaatccacac acatcaaaca catacacaca acacacacac aacacacaac 199560 attcctacca cacaccacac atacatacca cgcacacaca cactcacacc accctcaagc 199620 cacacacaca ccacacatca cacacacact acacacaaca ctcatgccac acacatcata 199680 cacaccactc aattcactcc cacacattca cacaccactt acacacacac cccacactca 199740 atccacacac accacacaca ctgacacaca tactacacac acaaacacac acacatacac 199800 ggcatgtgcc cctctccctg ggctggtggg agcggaggcc cctcgagagg aaggcaggcc 199860 ctgtgcccag gagcatcccg tctgcagaag gagtctgccc tccagcggga ggagtgaggt 199920 accgaagcca gggccccgtg agaccccggc aggtgggcgg tgagcgagtt cgcaggtgag 199980 gagggcgtgg gcactgcagg gcagcgggga cagcctgtgg agccgccagg aaccaaggca 200040 gcaggcctgg atgccgggtg caggggcttg ggcttcatgg agaccaaaag ggctctctgg 200100 agggtcttga gaaggaaagg gctgaggcca gactccagcc ttcttagagc tcgtcctggc 200160 tctgggtgga gaatgggcct ggcaggtgag ggagctgcct aaaggcagtg tgcgctgagg 200220 ccgctggcca gggacctgga ccacctgcca tggaacagtg cgtactgagg ccgctggcca 200280 gggacctgga ccacccgccg tggacagtta cactgcttcc ctcacccatc ctctggtgac 200340 acatcctccg gtgacacatc ctctggctgc tgttagagat ggaatttcac tcggtcaggc 200400 ctggggcaaa ccactcagag gacacagggg gccaagggag cccaggcaac ttcctcgatt 200460 cgcacctctg tacgggggat ccaggtcact ctattttctc accatttgag gggccgggtg 200520 cagccatgcc gccgttgccc tgcatagaga caggtggctg ggctcagtgg ctcacgcctg 200580 taatcccagc actctgggag gctgaggcag gtgtattgcc tgaggtcagg agtttgagac 200640 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacacaaatt agccgggcat 200700 ggtggtgggt gcctgtaatc ccaggtgctc aggaggctga ggcaggagaa ttgcttgaac 200760 ctgggaggca gaggttgtag tgagccgaga tcacaccact gcactccagc ctgggcgaca 200820 gagcgagact ctgtctcaaa aaaaaaaata gagacagggt ttcaccacgt tggccagact 200880 ggtcttgagc tcaggtgatt tgcccacctc agcctcccaa agtgctgaga ttacaggtgt 200940 gagccaccgc gcctgggccc tttctagtct tcttaaaatt cagttttctg tcaagagcag 201000 caacccaact gtaaattact gtggtcaggg actaagtcac cttggtgtca tcctggtgtc 201060 accctgatgt caccctcgtg ccccagcacc tagcatggcg ccaaattggt ttttgcagca 201120 agaataagtg agtatggcac ttacaatgga aaaaaaccca atagacttta tttaattaaa 201180 aacattaact ttctctggca gtcaaggttg gagccacccg ggagagccgg gcgtggcaaa 201240 cacacaggcc cgtctggaaa gctctgccag cggggctcct gacccaggtc cagcaaaagc 201300 agctcaaggt cagcctcagg gcctgacatc tcccaggaag aatccaaaac acccccgctc 201360 ctcagcagca ctgtcctcac ttgcacaccg tcctcgcctg cgcaccgtcc tcgcctacgc 201420 accgtcctcg cctgcgcact gtcctgcgcc ctcccaacct gcacttagca aggtcatgcc 201480 ctgaggtttc agaacaaatc caactttcag gacaatttga ctagaaaata caggccaaaa 201540 atccaccctg ggatctttgc tgcagtatag attttcttgt ttttgccctg aacgagtcag 201600 ttaacgattc agattaacaa gagatctgag cctgggagta tctgggagtc atagagagaa 201660 cagctacggg ccagggccat tagccaaggg gctgctgatg ctgggaggcc tggggcaagt 201720 ggacgggctc acaggccagc tttgaggggg atggggtgga tgactctgag cccagaccag 201780 acatctcccc acctcaggcg ctgtctcacg tgccgccttg tggggttaac tttgaatgtc 201840 aaagcccaga attttcacta gggtcgcctt ccatcctgtc ccttcatttg agaagcggaa 201900 agcgaggcac ctgtgtggga ctggcccagg ctgtgcagtg gctccccagg tgtcctggtg 201960 gcacgtgggg caggaaagtc gcatcagtca gggttcccag agaggccgaa ccaccaggat 202020 gtaacacaca cagggatgga ttgtcaggaa tgggttcatg cacttgttgg ggctgtaaac 202080 ccggagtctg cagggcaggc tgcagcctgg acacacccgc gggagttgat gttgctgttc 202140 ctagactgga ggcaggttcc ctcctctccc aggaaccgca gtctttcctc ttgaaggcct 202200 ttcttgtttt gtttggcttt ttcacagtgt tggaatgtac atttcctttt tttctttctt 202260 tctttttttt tttttttttt gagacggagt ctcactctgt caccaggctg gagtgcagta 202320 gcatgatctc ggctcaccgc aacctctgcc tcctgggttc aagcgattct tctgcctcag 202380 cctcccaagt agctgggact acaggtacag gccaccacac ccagctaatt tttgtatttt 202440 tagtagacat ggggtttcac tatgttggcc aggatggtct caatctcttg acctcatgat 202500 ccgcctgtct cggcctccca aagtgctggg attacaggtg tgagccacta tgcccggccc 202560 tggaacgtac attttcttag cagaacttat taagaacata attacaaaag aatttcaaca 202620 agtcaatgat agcatacaaa agaaagaagg gaaaaaatat atattttatt gagacagagt 202680 ctctgtcacc tagacaggag tgcaatggca tgatcttggc ccactgcaac ctctacctcc 202740 tgggttcaag ggattctccc acctcagcct cccgagtagc tgggattaca ggcacccacc 202800 atcatgcccg gctacttttt gtgtttttgt agagactgga tttcaccatg ttggccaggc 202860 cggtcttgaa ctcctgacct caggtgatcc gcccacctcg gcctcccaaa gtgctgggat 202920 tacaggtgtg agccaccacg cccagccaaa aatatctttt aaagtactca ttattttcac 202980 tttgttggga aggtaggtat ttatatttaa tagttgaggg aatatcgaat gtttcttttt 203040 aatagatgct aagcaggata gttagtaacc gacatgttta atattcaaag ttaaaatact 203100 tgagaacaag tattaggtat ataggaaaat ggaatggaag tttctccacg tttgtctttc 203160 catagccaaa agaggcagaa acttttcttc tgagtctctc agaagaaatt ccaagaagac 203220 tagaagccgc tggcatgaag agtaaacgtc taactatcaa aaccatggca cgaaagccgg 203280 gggcccctgt agaaactgca aaatttggag gccgtggaat ttgtgataat attgccaggt 203340 gagcacatct caaaaatgat attggcaatt atatttcagt ataggttgtt ataactaaca 203400 gaaatgaaga aaacccgcga gccgggaccg cgggggaagg tgtccccggc gtttgccgcc 203460 tgccgagcgg ttcggttctc ggctccctgg cagccggcct tcaggtcggg cgtcttcgtt 203520 ggtgacttct gctttggccc tcccggtgtg gccgctggtt gggctgcact gctgtgaccc 203580 atcatcatct cctgaagctg catcctgtcc tgacttgcct ccacgcttgc acactgagaa 203640 atgcagcacg ttgattcact tgcttaagga atgtcacaca aatcacagca ttctgaaatt 203700 tcttggtcat tgtaaccatc ttgattggga gatgagaaaa tgcctgaaga aggagtacat 203760 agaaaagagt tctggccagg cacggcagct cacgcctgta atcccagcac tttgggaggc 203820 cgaggcaggc agatcacgag gtcaggagtt caagaccagt ctggccaaga tggcaaaacc 203880 ccatctctac taaaaataca aaaaaattag ccaggcatgg tggcacacgc ctgtaatccc 203940 agctactctg gaggctgagg cagagaattg cttaaacctg gaggggtgaa ggttgcagtg 204000 agctgagatc atgccactgc actccagcct gggtgacaga gcaagactcc gtctcaaaaa 204060 aaaaaaaaaa aaaaaaaaag agttcaagac cagcctggcc aacatggcga aaccctgtct 204120 ctactaaaaa ttagctgggc gtagtggtgc gcacctggag tcattcccca gagctggagg 204180 tgggtcctga atcaccacag gcctcatgga tgtcccgctc tcccctgtgt cctgagtctc 204240 tgacggtcag gccccagcac ccagccaggc ctcctctgag gaatggccac aatggcaggt 204300 ttggaaagcg gcccagacat cacagatttc tgtaataatt cgagatcatt tggggtccag 204360 ctcccaggca ctgtctcact tcattcccga agtgtgaaac tgtgatatta ggaatttgaa 204420 tacagccagt ccctcctgac tgctggcgcc tgtcctttca ggagggtgac gcaggccact 204480 ccgcatcagg gtggataact ctgggacctg ttttttaacc cttgatattt accgactttg 204540 gtcagttcac caatccccag tctcaaattt gcgaaagtaa atgctatgcc cttttcatag 204600 agctgtcatc cataaaaact gccactgtgt tccctcactc tgtcccccaa tgagccctgc 204660 agcaggtggc ctgctgccac gctgggaggt gctctgagga caagcccatg cgtgctggtg 204720 acagctgcag ccccttccct ctgtggtcct gcctggctgc tggtccagag ccccttcccc 204780 agcccaggat ggctctccat ccctttgggt gcctgagaga gcaaacacct ggtctcatat 204840 caccggcagt tgtggactgg ctggacggtg ctgagagcgg gaaggaaaga ggggcagagg 204900 gcatctgagc ctggattcct gctctttctg ccagctctga cctggaccca cacctcctcc 204960 cagcccccat ccaaagcaga gaggaggcac aatcagaaag ggaaaagtaa aagaggaaag 205020 aggggtgcaa ggaccaaaga ggcacgcttc aggtaccaca aagtgatgag gctgcacccc 205080 aaaccccatc accataatca tctgctatgg actgagcatg ttcatctgtc caccactgca 205140 tctggctctc tgtataaatt atctcacata cagaagcagg tcacagccca ccttgtgcct 205200 cccctctctt ctctgctgcc cccttgcaat catgcaaact catcgtccat cttaaaaata 205260 cggctggaat ggggagcata ccccttcaaa tatcagtctc ttaattgaaa gatgtgcaaa 205320 gacacagttc gtactcaatg cttcattctg ttaatttctg cattgttgtc tatttgtaaa 205380 gttctgtgtt cataacaaac tcttttttaa tgttatgatt tggttttttg tttgtttgtt 205440 ttgttttgag acagagtctc gctcggtcac ccaggctgat gtgccgtggc acgatctcgg 205500 ctcactgcaa tctttgcctc ccaggttcaa gccattctcc tgcctcagcc tcccaggtag 205560 ccgagattac aggtgcctgc caccacgcct ggctaatttt tgtatttgta gtagagacgg 205620 ggtttcacca tgttatccag gctggtctcg aactcctgac ctcaggtgat gtatctgcct 205680 tgacctccca aagtgctggg attataggca tgagccactg cacctggact tgttttactg 205740 aaatcactgc agcaggcttt gagtgcctat tagtgactca ctttcactga gcaagaggta 205800 gattttaggt ctgcaacaca gcacatgccc ttgacaagct cacaaacttg taggagggat 205860 aggcctagac ctgtagacca tgtgtaggag ggaccaggca tagctcccag ggagggggct 205920 gcccataagg tggtcctctt gtccaaagtg aaatggctca tatgacgcag cctccactgt 205980 tctgaattct gcctctaaag aacccagaaa atgctgtccc gcaagaggat tccttaggta 206040 atgacttgag tccatgagtt ctcctagaag catttctcaa gttagactga agaaaacatt 206100 ttcttttgag ccaaacttcc tttcattggt ataatcctat ataggtagcc aaagcccttt 206160 tacttgtatc atctactttt attcttacaa caaccttagg gagtgggtag gaaaaaaacc 206220 tactctcacc ccatctcaca aataagggaa attacaaggg tattgagtgg tgaattttgg 206280 gaaagaaaat ctgttccttg tccagaaatt catttattca tttatctttg catccatcca 206340 tgcatccatc catctaccca cccacccatc cacccatcca tccacccatc cacccttcca 206400 cacgttcacc catccatcca tccatccacc catacatcca tctacccacc cattcatcca 206460 ttcaaccatt catctatcca cccatccacc cacccatcca tccactcatc tatccatcca 206520 tccatccatc catccatcca tccatccatc catccatcca cctacccacc catccatcca 206580 cccacccatt caaccattta tccacccatt aaaccatcca tctactcatc catccatcca 206640 cccatccatc tatccattca cccactcatc caccatccac attcatccaa ccatccatcc 206700 tccatatatg tgttgggtgg gtccctatta accagtccca gggctatatg ctggaggacg 206760 aaggaggccc tagctttcag ataactccca gtctggaatg tttggatcct ggagattatg 206820 gcagtggctc attttctcct taacaactca atattattac cttacccaaa tacagtctga 206880 ggacaggcaa agcaggaagc agattccttt cgttggattt ggggtgtggg tgcagctgca 206940 agcagtaagg cacagagaag aatactggtg tcccataagc ccctgagggt caccacacta 207000 agtgctgggt cgtaagttgt atcaaatgta ctgcctgagc ctttagtcaa tcctgtgaga 207060 ggatttctgg tctctccctc aacactaaga ggtagcaaat cttctcttga tggattaatg 207120 gatctaagag tcacgagggc tcctgattta tagcctgcat tcacgtctgc cctctgcata 207180 gcctggcaga atcttagagg aaagttcttg ggcagcaggg tcaagtaaag gttgttattt 207240 taaagagagg ggagaacatt gtgtcaacac aggaaggatg tcatgaagaa tgggacttgg 207300 cagttccctg cggctgggag gagggtccac atagtacgac agctctctgc cttcccaatc 207360 cagtcactca tcccttttag agctcagact ctggcaaaca gactcataat aacccaactc 207420 acaagagact gaatgatggc aatgtgcttc ttcctagtag gaggtaggtt cccagatctg 207480 cagccagggc ctctggcctg cagtaggtca tccccactgg agccgagcca ggaaagaaga 207540 gcctttcatg tatgttacca catgtaagcc tcttacagcc aactccttaa ggagctatga 207600 ctgaggttca ctgaaggggc aggaagtatc ccaacgtggc ccagcttgcc agagaagagc 207660 tggactttaa ctcaggccca gggctatttc ccggcctgcc ttccttcttc tctacctggc 207720 ccagtggccc accatagcct agttgttaga ccctagaggt caataaacct agtctcttcc 207780 ctggagactg aactgtagtc cagaattgag attgtgcgta tgtgacatgt gattcctgga 207840 tacataagac aacacacaga gcagagggat tgatccttac attttcgcag tcagggagat 207900 gctgagctgt gtctctgacg gtgaatatag aattgtaacc aagggagctg atgttctcag 207960 gagatgtttg cagccgggtg gagaagctca gtgcatgctt ttggggctac ttctggttaa 208020 ataatagaga ataagtgagc ccacaatgta gagataatgt gagcgagtgt tttgttgcgt 208080 aaggatgtga gagtctgagg gtgtgtggcg tggatgcaga atgtgagatt attgcagaga 208140 gtgaggctga ggaggctgca gcgcaggctt gggggataat tggaggatgc agttcccagg 208200 gagagaaaga aggagtccag tcatggttag aaacaccaaa tgattgtact cattatttct 208260 ggctcagtag caaattactc ccaaacttag tgacttgaaa caactttggt tattatggca 208320 cagatttggc aggtcaggaa tctggctggg agagctggtc cctctgctcc gtgtcccccc 208380 aaggccgtgg tcatctcaag gcccctctgg gaaggaccct ctttcaagct cattcacacg 208440 gctgctggtg ggtttcagtt ccttgcaggc cgctggaccg aagcctccct gggttccttg 208500 ccatggaggc tgccccgtag agcatcacac aacacggcag cttgtgttgt cagagcacgc 208560 aatcaggagg gccaaaagag aggggaccag taaggcggag agtgacagca ggatggaagt 208620 catagccatc cgtaacttag ccatggaaat ggcatcccat cagctttgct gcagtctctt 208680 cctagaagca agccactagg tccagcccac gctcaaggta tgagcagcag gaatgggacc 208740 actggggcct gtcagaagct gcctggcaaa acgactaaac aggaatcaag catttgctgt 208800 gtggtggaca ccagctaagc cttttatgtg cactctgtgc tatgaccctt cacaaagccc 208860 taccaggaag aggtcctgtt attattctca tttcatagat gaggacattg aggctcagag 208920 aggttgggta acctgctcaa ggtcacacag ccagagaaca gcagagctgg aacatgaacc 208980 caggcctgct gactacaaag ccaggacctc tccaaagcag aggtctccct gtcctccctt 209040 gcgagcttgg acaggaagtg gggcgaggtg gggccgggaa agccgccttc ccagccagcc 209100 tgcctgccct ctggctccac cgtctctgat ctttttccac tgtctttgct cgtttgactt 209160 ttcccctgtt gttcctactt tcttcatcca aacaaatcct gtctgctcac atttcaatct 209220 tccagctggg tgccagccag agtcctccct tcccttgaat atgcaagatt ggcatgcccc 209280 atgcagattt gccacaagca gagtgggctg ctgcctccgc atggagcagg gggcaccagg 209340 ggactctctt gctgtcccca gtatctcccg aatggcctgc ccccacgcct gggtggtcac 209400 cattagcaat cgcttcattt gggttatagc agcgaggatg ctggcggttc ctgctgaaac 209460 caggggaggc agaagcagca ggcagggagg cctttcccta cgcacacctg agactcccag 209520 attgctttgg tagccaacag ccagctggga gctgggcctc aaggagttgg gatataggac 209580 aggtcacttt aaaaaaaaaa aaaagtgtgg taagggccgg gtgcggtggc tcatgcctgt 209640 aatcccagca ctttgggagg ccaaggttgg tggatcaaga ggtcaggagt tcgagaccag 209700 cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaaattagc tgggtgtggt 209760 ggcgggcgcc tgtaatccca gctactcggg aggctgaggc aagagaattg cttgaaacca 209820 aaaggcggag gttgtagtga gccaagatcg caccactgca ctccagcctg ggcaaaaaag 209880 cgaaactcca tctaaaaaaa aaaaaattgt agaaacatac aaataacata aaatgtaccc 209940 ttgtactcac ttttgtgcac agttccgggg catttggctc attcacatga ttgtgcagcc 210000 ttcaccgcca tccttctcca gagcattttc atcttctcaa acagaaactg tccccatgaa 210060 acataaactc tccaccccac ccaccgcccc caggccctgg cagtttccat tccactttct 210120 gtctctgcaa gtctgactgt gttaggggct tcatgcgagt ggaagttgac aggatttttt 210180 tttctttgag acggagtctt gctctatcgt ccaggcttag agtgtagtgg cttgatctcg 210240 gctcactgca acctctgcct cccaggttca agcgattctc ctgcctcagc cttcagagtt 210300 gctaggatta caggcgcccg ccaccacacc cggctaattt ttgggtgttt agtagagaca 210360 gggtttcacc atattggcca ggctggtctc aaactcctga tctcaggtga tccacctgcc 210420 ttgcctccca aagtgctggg attacaggcg tgagccaccg cacccagctc agcatttgtt 210480 cttttttatt tggcttcttt cgcttagcat aatgtcctca aggctcctct gtgttgtagc 210540 ctgtgtcagt gtttcactgc ttttcgaggc taaataaggt tccattgtat ggagacacca 210600 agttttgcgt atccgttcac ctagcaatga acacttgggt tgcttctgcc ttttggttgt 210660 gtataaagat gccaggaaca tgggtgtgca aatatttgtt caggacaagt cacttggtga 210720 tgaaccaaga aggggacagg tgtggagggt ggggctgctg gagctgccag ccttggaggg 210780 aaaagcagag tggggggtgg tgggctggag gaggtccgga gcctggggga ggtgcagggg 210840 agggagtagg gagtggggat gaggtgggca gcagcaggga tatctgtagg agacgctgcc 210900 ttcccatgat accacctgcc ttgggcagaa ctatgttttc tccgtaactg gggtctcccc 210960 agcattccaa agaggtaggg atatttgggg aacctgagag ctgtcaagaa acagctgtca 211020 ggcagccgaa cctagacttg ctggcccata ttcaggattg cttccaaggt cgggatcagc 211080 caagcctggc gggaaagagg caaatgctgg tcactgtctg gcaatgcatg atgtggcaaa 211140 gggactgggc tgctgtgata cagagcactg ctcatatgca tgggtcagct aatgcctggt 211200 aacaaacagg acctcagggg ctgcactagc actcagggct tagcaagttt ctgtattggc 211260 cagttattgg cacaataatg atgaatgcca aaccagtccc aagctcgggg gctagctcag 211320 catcactgat ttcctgggcc tgtggctggc atggctctgc ctcacaccac agattgggct 211380 gggtctccca ccctcctggg ctcgctcggc ttactgaggc agcttcttgt cctggtgacg 211440 gcagaggcaa cagaaggcaa gcccacccac gcacgcacgt ctgcaagccc ctggctttgc 211500 tctgcctgtc ttgctggcca aagctagcct caaggccaca ctggacgtcc agggtcaggg 211560 aagcagattc tgcctatgtg ggaggagctg caagtcacat gacagagggc agggacacag 211620 ggaggggtgg tgagaattgg ggcaaagctg ccacctttct ggaatgttcc aaaagaagat 211680 ggacgactac tgctcctcgg ccctggaagg gagagttctt ttttccccac tataaagttt 211740 tctgattcca attccaaaat gctatgactc ttaatcaatg cctgatgaac catacttgag 211800 caaacataat ttattctctg tcaagatcat cctgagggga tcgggtgtct ttgtttccct 211860 cctaaatccc ctgcgaattc atctttttta ttccaggctt actaggaaat aaaagatttt 211920 gtctgagggc tgatgggtat tagcagagct atatggagct tgagttgaaa cttggaatgt 211980 ttgtggatca aaaccgagct gtgctggcag cgtctgggag gagggtgcac tcgctgaaac 212040 tctgcccgag ttgtggctgt cagctgcctc gactgccaga ccagactcgc tgttttgggg 212100 ccgggtgggg gggacggcgg ggggagtgtt gttacggatt gtgctggaag gttttcttgc 212160 tcttggcttt tttggtgaag ggcctggatt actgcagaaa atccagctta tgtgtccaag 212220 ggcaaagcag gcctgtttat ctttaacttt tacatgcttc acacatctcc tgaggtttga 212280 ctctaagcag gatttgtgtc ttccctgatg caagaaaaca ggaggcaggc gctgagcttg 212340 caggaggcca cacagccagt gcacagcttg ccatatgctt aacgtggctc tgagaagaga 212400 gggttgtttt tttaatatta aaaatggcta tgggaaaatc tgccctaatg ctattaagca 212460 gtgctgatat gagatgtgtg tggctgtaac tttctgattg gatttgggat ctaggctgca 212520 gccagccaga cgctggagac acattcctga gccacctcag cccttgcctc tttgccgagc 212580 tgcggctatt ctttggggca cgcaggtaga tgcagagaga ctgaagtctt cagaggtggg 212640 tgtgcacaga agagtgattc ccagatcagg gaagactttg gcccccagat gacatttggc 212700 aaagtctaga ggccttttca attgtcacaa ttgggaggag ggaggtacag tagcatctgg 212760 tagatagagg ccagggacgc tgctcgacgc ctacagcaga tggactcaca gccaagaatc 212820 atctgcccct aacattattc agccttaact tacaaaggaa ggaaagtctg gtgcatgtgt 212880 gctgtggttt gagtgtgtcc tctccaaaat tctgtgttga aacttcatgt ccctgtgtcc 212940 taattgcctt aagaggtgat taagtcaaga gaacgcctcc ctccataaag ggattagtgc 213000 ccttataaaa gggctttgag gctggataca gtggctcacg cctgcaatcc agtactatgg 213060 gaggccgagg tgagtggatc acttgagccc aagagttcaa gaccagcctg ggcaacatag 213120 tgagaccctg cctctaaaaa aaaaaaaact gggagtggtg tcacatgact ttagtcccag 213180 ctatttggga ggctgaggcg ggaggatcac ttgagtacag gaggtcaagg ccatggtgag 213240 ctgtgattgt accactgcac tccagcctgg gaaacagaac gagaccctac cataaaaata 213300 ctactactaa taaaagagct ttggtgaagg gagtttgtcc ctcttgcctt tctgccctcc 213360 accacgtgag gacacagcgt cccccccacc aggaggaggc agtgctccaa gtgccatctt 213420 ggaagccagg ctggaccctc tccagacagc gaacctgctg agccccggat ttcggactcc 213480 cagcccccct ggcaaaggcc cgtgttctct tccaacatgg tctagtggct acatctttgg 213540 gagggggcga atgctgaggc ctcacatggt ggacccactc cctctggccc tttgataggg 213600 accctaattc catccgtgaa gtctccaccc tcgtgacctc atcacctctt acggtgtcac 213660 ctcttaatcc cattacaatg gtgagtaaat gtcaacatat gaatttttga ggggacacca 213720 tcatgcaaac catggcagtg gtgccggcta tgtaagtagc tatgactgtg cagaggtcac 213780 catggccatc tcacatgcat gtcactcaac catcaaaact cacccaacag cagttgccca 213840 aagcccccca ccctgcccca cttgtaccca caggcactcc agtcccagct ccaaattaca 213900 tttgtgcagc cttatttctc caagtggctt cccacaagct tgagatgcag gtggtcgtca 213960 gggaaggtcc tcatctctcc ccattggcca acttggtttt atatcacctg ccctgaagtc 214020 cctctgccag aggagagcca gtgactgtgc caggtgcttc cttggacaca cccaagctgc 214080 cgtcttaaag aatcaccccg tcaagctctg ccacgttttg tcatccggcc ccacatttcc 214140 ttcagctgta tctcccaccg ttcccaaatc caacaacggc gcctgtgcgt ggccaggagc 214200 gcagagaggc aggggtggga gttcccccag agcctggctc cagctcacag ctcagacacc 214260 ccgtggccct cctgccctgg gcccggatga gtcgggaata cgggactgct ctccaaggtc 214320 cccccttccc cgtctgcagc cagtcagcct ctgagtcctt atcatctgtt tcccaaatag 214380 ttccagatcc ctccctctct gcccttcccc cctcatgccc aggtttgggc cactattaca 214440 atttacctgg attacctctg cagattccca ggctgccgtt ggcaacagtg gaaggtgcag 214500 atgggggcga ggaagatggt ggcgcactgc ctctgtcctt ctctgctctg agttggagcc 214560 aaccccgagg tctccttgcc cctggcacgc ccaatctcat tgtcatgcac cagagaagtg 214620 gccgggaagc tccccggggc ctggtcactc ggcttagtcg gctctgtcac ttcccccccc 214680 gcacctgctc agcccattga ctctctgact gcacctcagc ccctgccccc cgccaggcag 214740 tcacctgcac ttctgcatcc tccaggggcc tctctttccc acctcagggc tcagtgcaaa 214800 cggtgccttc tttctcgaat gtggataatg gaggaaaaat gttgcttccc cacgaagcct 214860 tcccaaccgc ctaatttgga tgcagtgtcc catcctgggc ccttagccct gttgcagtgc 214920 acggtggttg acggcccatc atccttctcc cctcaggaca gaggccatgt cttgcttgtg 214980 gacccttgat cctgtgtgag ggacacgtgc ctcccaaatg cctgggctca gccttctctg 215040 gaggcttctt cactttgtgg ggatcctcta ggtgtgtcgg ccacatgatt ccccttcact 215100 gattcatcca gcaaattcat tcccctccac tgattcatcc ctgagcattg actctgatgg 215160 gcaccagggc cgtagcaggc ccaggcagac ctcgctctca ctggcctctc ctgcggagga 215220 gaagcagacg ataaacaatg gctgggctat gatgggcggt ggcggcgcag tggagagaga 215280 tcagacaggg ggagggcaca gagagaggct gagggggctc ttttgggagc agccatagaa 215340 aacttctctg agtgacgacg ttagagacct caaggaagtg agggaacaag caagtgttgc 215400 tggcgttggg aacggcaagc gccgggcttg gggtggccca gggagagcac gggtcagcac 215460 gcctggagtt cagcagcgtc agggaggtaa cagggtcgga tcctgtaggg cttaggggtg 215520 atgttaaaca ctctggaatc atcctgcatg agatggggtc attggacgtt ttcgaaccct 215580 tggggttcct cctctgattt aagctttgag agacccactt tgcaaagttc ccgctataca 215640 ctctatcatt acatcctcac aaattgcctg ggcacagtgg ctcatacctg taatcccagc 215700 actttgggag gccgaggtgg atggatcact tgaggtcagg agttcgagat cagcctgacc 215760 aacatggtaa aaccccgtct ctactaaaaa tacaaaaaaa aaaaaaaaat aggtgtagtg 215820 gcaggcactt gtaatcgcag ctactcggga ggctgaggca ggagaatagc ttgaacccag 215880 gaggcagagg ttgtagtgag ccaagatcat gccactgcga cagagtgaga ctccatctca 215940 aaaaacaaca acaacaaaaa taaatcaaca tatgggtaat cttttcccca ttctacagtt 216000 gagaaaactg aggctcagag agaaagggta gtgacttacc tgagggtgca gagcttgagt 216060 gtgttgaact ttgctggaat ctggctcaga ttcattctaa aggccccact ccagctgccc 216120 tgcagtagga atggcttgac cactctgctc cacaggccca aagacaggat ggggtcaggg 216180 ccaaaatgag tggtggtaag gtccaactcg gttcttcgag aagtaaatca gctcctgaga 216240 cgtcgatctt ccagctgcac cctgtcacta ttgagaccta gccaagcact tgggggcaat 216300 tatatgggtg gctgtggctg tattggaagg cctgagagag gagggagtca caggtgaccc 216360 tcttgagcag gagactcggg cccaagattc agggactgcc accttggtga cagtgtcaat 216420 gttggatgat tttaggtaaa tgatgccttc acagaggcct ttaacccagc ggaaaccagc 216480 ttggcaggta catgcttttt tccttccttt tcggtttcat tctaccaacc tccctgattg 216540 ggttataggt ggggttctcc gaagctccct ggaaggcccc tcaggcttac tcgggagtgt 216600 ggaggtggag gggattattt gctcactccc caggagcaga ggagggagac tgtcccttga 216660 ttgggggatg ctctgagaga tgccgtctgc tgtgaggcgg gaagaggagg ggctccccgg 216720 tcctcccggc tgctcttccc acctcttttg ggagcatggg atggaagatg cataaaaatt 216780 caaaccatcc tgaaaataaa tgaaaggaaa atatatatat ccaagaagga gataaccata 216840 gcaatcactt tcactcaaag gtaataaaaa taaggatcgt aaacataaac tcagaaattg 216900 caagctgcac tccctgccga cgtttgctgc catgagagag cacattccga gggaaggcaa 216960 ggactttcca gactttccag gacactctgg acatgtctct ctgattgaaa cctccagaag 217020 gaaaaatatg ggaggaaaat agtgagttat gggggggaaa taaggaccca aactataaca 217080 aaaatggaga acacaaatta tgtttacaaa cgtttccctg gctgacagag actctgcctg 217140 gaacagatca catatcataa ggtggccacc ttcccagggg tgggggctcc tgggtgagta 217200 cagagtgttc tgtgagtgac ggccccccct ccctgcccgc ccccctccgc cagcctcatg 217260 gagctgcact ggagatggct tattctgagc gtcagctgcc gccttcctcc tctgcagcca 217320 tcagaccgaa gctgccgctg tgacaagcaa accagacaag atggaccgcg gcagctgggc 217380 tgtctgcaga gggccatcca ggcctccttg ctagaaacat gcattttaga tggacaaacg 217440 gaacattttg tcctctttgc cttctgatat ttgtcttctg ccagaagaga gctaggaccc 217500 aggcatcaaa ctacagccag tgaaatgttc ctaactccct gcttgggttg catcctgcga 217560 cggctgctca ttgcccgaca aacgcttcgt cctgcctggg catcatcctt cagctgtaac 217620 cggcgatgcg attcccaagc actgtttaaa ctttccagtc aaaaatgaga caccactgct 217680 cacttatcag atttgcaaaa atcaagataa taaagctaag gaaggctggg tgtggtggtt 217740 caggcctgga atcccagcac cgtgggaggc agaggaggga cgattgcttg agctcaggag 217800 ttgaaagttg cagtgagccg cgatcatgcc actgtcctgc agtgtgggtt acagagtgag 217860 accttgactc aataaaataa aatataaaat aaaataaaaa ataaataaag ctaaggagga 217920 aaaccaaaac atggctagtc agtttgggga aggtgggacg acacggtgtc ctcatgccgg 217980 ttcgtttgca aactggaatg atcttttcgg aaggaatgta ggagtgtctc aggaatctgt 218040 aaaaagttca cagccaggca tggtggctca cgcctgtaat cccagcactt tggaagtcca 218100 cagtggcagt atcatttgag cccagcctgg gcaacatggg gaaaccctgt ccctacaaaa 218160 aatacaaaaa atatttgctg gatgtggtgg tgcatgcctg tggtcccaga tgctcaggag 218220 gctgaggtgg gaggatcctt tgagcctggg aggcagaggc tgcagtgagc catgattgtg 218280 ccactgcact ccagcctgga tgacagagtg agactctgtt tcaaaaaaga ataagttccc 218340 caccttgatt tgctatgagc tgaattgtgt cccccagaaa tccagttcca agtcctaacc 218400 ctggtgcctg tgaatttgac tttatttgga aatagggtct ttgcagatgt aattaaagtt 218460 aagatggtat gtctgctgtc tttattttat ttatttattt tttctgagac agagtctcgc 218520 tctgttgcct aggttggagg gcagtggggc gatctcagct cactgcaacc tccatctcct 218580 gggttcaagt gattctcctg cctcagcctc ccaagtagct gggattacag gtgcacatct 218640 ggctaatttt tgtatttttt tttttccagt agagacaggg tttcaccctg ttggccaggt 218700 tggtctcaaa ctcctgaact cgagtgatcc gcctgcttcg gcctcccaaa gtgctgggat 218760 tacaggtgtg agccactgca cccagccgtc tgctgtcttt atgagaggag agacacatag 218820 ggagatggaa ggccctgtta ggatggtgcc agaggtagga gggatgcagc cgcaagctga 218880 ggcatgtagg aggttgctaa ggacaccttg aagctgagag aggggcacga acagattctt 218940 cctgggagcc tggaggcagc agaaccatgc tgacatcttg atgttggaat tctggcctcc 219000 agaaccgtgg agcaatacac ttgttgcttt aagctaccca gtttgtggta ctttgttaca 219060 gcagccctag caaactaaga cactctattt ttatgttttt tgagacggag tcttgctctt 219120 ttgcccaggc tggagtgcag tggcacgatc tcagctcact gcaacctctg cctcccgggt 219180 tcaagtgatt cttctccctc agcctcccag tagctgggac tacaggctcc caccactacg 219240 tacggctaat ttttgtattt ttagtagaga cagggtttca ccatgttggc caggctggtc 219300 ttgaactcct tacctcaggc gatccactcg cctgggcctt ccaaagtgct aggattatag 219360 gtgtgagcca ccgtgccggg ttacaaacta atacactctt tttgggcttt tactttcact 219420 tctaggaaga aatattgtag ctcattattt tccacattta tttttatttc cacatagtca 219480 gactatattt cccagtgtcc tctgcagtta gctatggcca tgtgatcgag ttctggccaa 219540 tagaatgtgg ccagaagtga cataaacgcc agacccggcc aatggaaacc ttgtgctccc 219600 gttcgggggt ctgtgccccc aaggttaccc cctaacacct actgaactac tgtatgtgtg 219660 aaaaatggcc ttctattgat gctggggagt tactgttcca gtacttagca cagcttggct 219720 aatacaagga aaaatcagag ataaagaaaa gcaaagattc acaggccagg atgtttccat 219780 attccacatc atttactggg ggcagcagcc ggggcacaag acaaactcac ttttcttttt 219840 tttttccttt ttttttgaga cagagttttg ctctgttgcc caggccagag tgcaatggcg 219900 cgatctcggc tcactgcaac ctccgcctcc caggttcaaa tgattctcct gcctcagcct 219960 ccctagtagc tgggattaca ggcatgtgcc accatgactg gctaattttg tatttttagt 220020 aaagacgggg tttctccact ccatgttggt ctggctggtc tcgaactact gacctcaggt 220080 gatctgccca cctcggcctc ccaaagtgct gggattacag gcatgagcca ccacccctgg 220140 ccactcactt ttcttttaat attcagggca gcatgacccc aagtctttgt cctttatatt 220200 tctgggcagc cattcctttt gggatgtcat aggggtccct ttaggccctc cccagatcag 220260 cctcctgccc cactgctccc tccatctggg gtttatccca ttgctgtgga cagagagagt 220320 cgtcagtatg ccttggggcc agtgttcact ctgggctgtc tgagctgttc aaactctccc 220380 tgccaatgtg tgttccctgc tcctgtttct gcttctagca gtagctcctt ggggtcctgc 220440 tcattggagt catttgacaa tactgggcca ggcatggtgg ctcaagcctg taataccagc 220500 cctttgggag gcagaggcag gcagatcgct tgaggtcagg agtttgagac cagcctggcc 220560 aacatgggga aaacctatct ctactaaaaa tacaaaaatt agccaaaaat cgcttgaacc 220620 caggaggcag aggctgccgt gagccaagat cgtgccactg cacttcagcc tgggcaacag 220680 agtaaaactc cgtctcaaac aaaacaatac tatgtgccca cactgcatac caggcgctgg 220740 ctctctgcag ggggtaaaag ggagaatgag acagatatga tccctgtctt cgtggagctt 220800 ctatctggcg gggcaaaggg acattaaaac aatgtttaat tagaatagtg attagtgcaa 220860 tgaatacaat gtatagggtc ccatgggagt ggatacaagg tagggtgact atgttttatc 220920 atccaaatca gaacaccttt gagaatgtaa gaggacacta ttaataatta tgccagagga 220980 atgagtgaaa accagggctg cctcagggaa ggcagaacct ttggccacct aggaggagac 221040 caacccagtc cccgacaagc tgtctctgag cagctccctc ccagctttgg acccagccct 221100 gaccaatagc tcgggggagc ccacacagct tggatgagtt ctcccaggct tgactgaacc 221160 tcactcttca gaaaacacct taccacctcc ttcagggccc aggtgggctg gaaacaagtt 221220 ccctgtatgt gattaacaca atggttgaga atacaggacg aagctgtggg tctcacagtt 221280 tgctacgcat ggactcacct gggattccag gctgactctg ggctgccatc ccctaacatt 221340 gtgatgaaat gggtgcaact ggggcatctg gaattttatt gattgattga ttgattgaga 221400 cacagtctca ctctgtcacc caggctggag tgcagtggca tgatctcggc tcactgcaat 221460 ctccgcctct ggggttcaag caattcccgt gtctcagtct ctctagcagc tgggattaca 221520 ggcccacacc accacacctg gctaagtttt gtatttttag tagagacggg gtttcaccat 221580 gttggccagg ctggtctcga attcctgacc tcaagtgatc tgcccgcctc tgcctcccaa 221640 agtgctggga ttacaggcgt gagccaccgc acccggtcat tatttattta tttatttatt 221700 tatttatttt tgagacagtc tcactctgtc acccaggctg gagtgcagtg gcacgatctc 221760 cactcactgc aacctctgcc tcccaggttg aagcgcttct cctgcctctg cctcctgaat 221820 agctgggatt acaggcatgc gccactacgc ccagctgatt tttatagtag tagagatggg 221880 gtttcaccat cttggccagg ctggtctcaa actcctgacc tcaagagatc cgcccgcctc 221940 ggcctcccaa aatgctggga ttacaggcat gagccactgc acccaaccga tgatctttta 222000 ttttcaaaat gtttcagaat aatttttttt aaatgtcaaa taatttttaa aaacgtggca 222060 aaaagaaaag gaaaaaagga aattcacaaa atcagaacac tgattcctct gcttaacttt 222120 tattttcttc atttttggga acattttcca atttcctcca acaagcatct attacttttt 222180 acttttaaaa tttaaaataa aaatggtcaa agtatgacgt gatgctgttt aaaatgtcaa 222240 atggtatttc tgggatcata ataccagtgg gtccctggcc tccccatttc tggtcctgtg 222300 acccttggtc cacatgtctg ggcagagtga gatcctgtct ttaaaataca tctcagcatt 222360 tctacacgtg tctacggtct ttttctttgc gttttaaaaa ccaggttaca ggccgagcat 222420 ggtggctcac gcctgtaatc ccagcacttt gggagtccga ggcaggtgta ttgtttgagc 222480 tcaggagttc gagaccagcc tgggcaacat ggtgaaaccc tgtcactaca aaattagtcg 222540 ggtgtgggct aggcgcggtg gctcatgcct gtaagcccag cactttggga ggccgaggtg 222600 ggcagatcac ttgaggtcag gagtttgaga ccagcctggc caacgtggag aaaccctgtc 222660 tctactaaaa atacaaaaat tagccgagtg tggtggcaca cacctgtaat cctagctact 222720 cgggagggtg acacaggaga actgcatgaa cctgggaggc ggaggttgca gtaagctgag 222780 attgtgccac tgcactccag cctgggcaac aagagcgaaa ttccatctca aaacaaaaac 222840 aaaaacaaac aagcgaacaa aaatgtgatt gtgctacagt attatgacca ctacagcctc 222900 actaggtgat aggaattttt cagctccatt gtaatctgat gggaccaccg tgctatgtct 222960 agtccacctt tgaccacaac tgttctgccg ctcatgagtg ttacttacaa catccttatg 223020 aaatagacac tgttagtttc ccaatgttac agatgaaatg gggctggggt aagtccagct 223080 cctctcccag agcctcaggg caaggaattg acagagtgaa aactggaact gaggcctgtg 223140 tgactcccag cacaagcagg cgctggaggg cccccggcag ccacttgcag gctaatgggt 223200 gctcttgccc catgctgggc actgtgccac acattgcgag ggtctgcgct tagcatcagg 223260 cagctgtgct tggaatcttt gcccagactt ggtcagtgga gagatcttca gaaagttatt 223320 tcatccttgt gcgtctcaac ttccttgctg atacaatgga tctagaacac aagctcttcc 223380 caggggttat taggagggtt acaagtgtta attctcagga aaaaggcttg gctccccatc 223440 aatactcact aagtgttagg attatcctat tttacttaca ggcatatttc tctaatctcc 223500 cctatgaaaa gcagaagcaa tggttggcct acctttgtcc cctcaggatc tactgttcag 223560 ctgagagctt gagaatcact gatgttatgt aaatagtaca taaaataaca agtggggagt 223620 ttaaaaagag acagttggtc acattctttg tattttcata gattattaaa atgaagggtt 223680 acaaaaattc attttgcata ttattattat tattgttatt attattatta ttattgagac 223740 ggagttttcg ctcttgttgc ccaggctgga gtgcaatggc atgatctcag ctcactgcaa 223800 cctccgccac ctgggttcaa gcgattctcc tgtctcagcc tcccgagtag cggggattac 223860 aggcatatgc caccacgcct ggctactttt tgtattttta gtagagacgg ggtttcaaca 223920 tattggtcag gctggtctgg aactcctgac ctcaggtgat ctgctcacct tggcctccca 223980 aagttctggg attacaggcg tgagccaccg tgcccatcca gtttgcatat tatatattgg 224040 ataataaatt ttctcaacat agtctcaatc atataaactt tcctccccca ccccattttt 224100 cttttttttc tttttttttt tttgagacag agtcttactc tttcgcccag gctggagtgc 224160 aagctccgcc tcccaggttc acggcattct cctgcttcag cctcctgagt agctgggact 224220 acaggcgccc gccaccatgc ccagctaatt ttttgtattt ttagtagaga cggggtttca 224280 ccgtgttagc caggatggtc tcgatctcct gacctcgtga tccacccgcc ttggcctccc 224340 aaagtgctgg gattacaggc gtgagccact gcgcccggcc ccatttttct ttttcttttc 224400 tttttttttt ttttttggag atgcaagttc ttttattaaa ttctcaaatt acccaatttg 224460 tgtgggccat ctgtttccta cctggacctt gacacattca gaagtcaaca ggacactgtc 224520 cgaatgggtt ttggttagta acttccttat agcgtctctc actgtggctc acccatctgt 224580 gttgttctcc tcatccattc aggaaatgag attttttttt tttttttttt tttttttttt 224640 gagacagagt cgcactccat cgcccaggct ggagtgcagt ggctcgatct cggctcactg 224700 caagctccgc ctccccggtt catgccattt ccctgcctca gcctcccaag tagctgggac 224760 tacaggcacc cgccaccacg cccggctaat ttttttttaa ttaattaatt tattttttta 224820 ttgatcattc ttgggtgttt cttgcagagg gggatttggc agggtcatag gacaatagtg 224880 gagggaaggt cagcagataa acaagtgaac aaaggtctct ggttttccta ggcagaggac 224940 cctgcggcct tccgcagtgt ttgtgtccct gggtacttga gattagggag tggtgatgac 225000 tcttaaggag catgctgcct tcaagcatct gtttaacaaa gcacatcttg caccgccctt 225060 aatccattta accctgagtg gacacagcac atgtttcata gagcacaggg ttgggggtaa 225120 ggtcacagat caacaggatc ccaaggcaga agaatttttc ttagtacaga acaaaatgaa 225180 aagtctccca tgtctacttc tttctacaca gacacggcaa ccatctgatt tctcaatctt 225240 ttccccacct ttcccccttt tctattccac aaagccgcca ttgtcatcat ggcccgttct 225300 caatgagctg ttgggtacac ctcccagacg gggtggtggc cgggcagagg ggctcctcac 225360 ttcccagtag gggcggccgg gcagaggcgc ccctctcctc ccggacgggg cggttggctg 225420 ggcgggggct gaccccccac ctccctcccg gacggggtgg ctgccgggca gagacgctcc 225480 tcacttccca gacggggtgg ctgcccgacg gaggggctcc tcacttctca gacggggtgg 225540 ctgcagggcg gagggactcc tcacctccca gacggggtcg cggccgggca gaggctgcag 225600 tctcggcact ttggggggcc aaggcaggcg gctgggaggt ggaggttgta gcgagccgag 225660 atcacgccac tgcactgcag cctgggcacc attgagcact gagtgaacga gactccgtct 225720 gcaatcccgg cacctcggga ggccgaggct ggcagatcac tcgcggttag gagctggaga 225780 ccagcctggc caacacagcg aaaccccgtc tccaccaaaa aaatacgaaa accagtcagg 225840 cgtggcagcg cgcgcctgca atcgcaggca ctcggcaggc tgaggcagga gaatcaggca 225900 gggaggttgc agtgagccga gatggcagca gtacagtcca gcttcggctc ggcatgagag 225960 ggagaccgtg gaaagagagg gagagggaga ccgtggggag agggagcggg agcgggggag 226020 ggggaggggg agggttcttt ttctttttta ttattttttg agatagggtc tctgttgctt 226080 aggctggagt gcagtagcgt aatctcagct cattgcagcc tccacctcct gtatataagc 226140 aattctcatg ccccagcctc ccatgcagct gggattacag gcatgcacca ccacacccgg 226200 ctaatttttt tgtgtttttt acatagagac ggggtttcgt catgttggcc aggctggtct 226260 cgaactcccc acctcaggtg atccgcctgc ctcggcctca caaagtgctg ggattacagg 226320 catgagccac tgcacccggc cccttttttc tttttaaatc tgccatgggt acagaccaca 226380 tctttgtgat tctaccttta ggatctgggg gaggaaggaa gggactccca ataatgggat 226440 gtttgacctc caacggacac tgtaccttca tcccttctcc acaaagaatc cgtagggccg 226500 tagacagcag cgtctgatgc cgtaaagcct tgcagatggc tccccaagtc catccggact 226560 catcggtcag ggcgcccagg ctggaaggcc acccagcggg gactgggcct gggcacctgc 226620 tctcccagct gctttgccct tgtcttgctc cacatggcag gcgtctcaga gaggctcttc 226680 actgcccttc gcaaaacagc ccagggtggg aaggagaggc tggggtgcag gtcccagctc 226740 cgtgttgggc tctcaggcag tcccctccct gatgcatctc cttctcggct ctgtctttgc 226800 cgtgttttcc ttggctggct ttttaaggct agggctatgc aaaaatcctc acttctgaag 226860 gaagaaatgt ggacagtggg tgaagtttat tcagtaagag gcacttttca ccacagtccc 226920 tatgctaccc agggaccctt ttaaaaatgg gaataacttt gtttctgcta attgatctac 226980 atgcttatta tataaaaaaa tgaataaaat agaaaggtgt gctgtagaag gtgaaaatca 227040 catgcataaa taccaccata tttttagacg ggtggagagg gggagacagc cttgctgggc 227100 tcctggcagc ctcacattcc cagctgaagg caatgctgtg gccgtgttac ctccttttcc 227160 ttcctcttct cacttcactg tcaacaaagc atctgacctg caggggggag tggctcgggt 227220 tttactaaaa acggagtcat gatgctcaga caaaagcgac gttcttcatg tctattttgg 227280 tttcctttaa gttaagcata gatttttctg gaaaggaccg gagctggctg ttctccctgc 227340 atggaaaaca acagctcagc gaagcacctg gttttctcaa gttccctgac ctccagcctt 227400 gctcctgatt cttgatgaca aaacacattc agtgcccttg attgatttag cagagaagtg 227460 gcaatgctgc cgcatggaac gcagcccatt ctgcctgtga atggaatgcc tcggctgtga 227520 tggtcttctg ttttgggaaa agattaggtc agttgcagtg ggtcaatgct gagctcggag 227580 actgaatatc cagccacctt agttcttcct ggtaaaggct atttatctga gccatttatg 227640 caacccccac cccctgcatt tctccctgca ttcatttctg ccttctgtca tatttgcccc 227700 ccacactcag gtttttatat ttgttctctt gctcactttg ctgtatcttt aattccattt 227760 gtcgaacagt ctaagtttta gggtaagaag gagtcacctg gtctaccttt acatggtagg 227820 acaaggtgcc ccactctgtt caagcaggtt attctgcttt tttttttttt tttttttttt 227880 tttgagacag agttttgctc gattgcccag gctggagtgc agtggtgcaa tctcagctca 227940 ctgcagcctc aaactcctgg gctcaagcca tcctcccacc tcagcctccc tagtggttgg 228000 tactacagac gcatgtcacc atgactggct aatttaaaca attttttttg ttgttgaggc 228060 caggtgtggt ggctcatgac tgtaatccca gcactttggg aggctgaggc aggtggatca 228120 cctgagatca agagttcaag accagcctgg caacatggta aaactctgtc tctactaaaa 228180 atacaaaaat tagctaggcg tggtggtggg cgcctataat cccagctact ctggaggctg 228240 aggctggaga atcacttgaa cctgggaggc agagtttgca gtgagctgag atcacgccac 228300 tgcactccag tctgggcaac agagcaagac accatctcaa aaaaaaagaa ttattattat 228360 tttttttttg tcgagacagg gtttcccggt gttgcctagg ctagtctcaa actcttgggc 228420 tcaaacaaac ctcccacctc agcttcccaa agtgtgggat tacaggtgtg agctactgcg 228480 catggtctgt tccactcttt ttggatccta gctgggcctg gaagcccctt cagccccaca 228540 tctgcaggct gacgttcacc accagcagga ggctttcgtg gcatgtggtc ttacaaacac 228600 ctctgtgttc aagtcttgaa taagtgactg taagagactc atggagcagg ttgttgccaa 228660 caccctcccc cactttcttt cttaatttct gcatttttta aaaattaaga tgggatcttg 228720 gtctactgac taggctggag tgccgtggtg caatcatagc tcactgaagc ctcaaattcc 228780 tgggctcaaa ttcctgcttc aacctcacaa gtagctggga ccacaggtat aaatattaaa 228840 tttttttttt tggtagagac agggtctcac tattttgccc aggctggtca tgaccgtttt 228900 catagcttga atcaaaccag gtttgtgtgt tttctgagat tcctaacatt ttgtttttaa 228960 gattaaagta ttttagctgg acacggtggc tcatgcctgt aatcccagca ctttgggagg 229020 ccaaggcggg tggatcgcct gaggtcagga gttcaagacc agcctggcca acatggtgaa 229080 accccgtcta tactaaaatt acaaaaatta gccaggcgtg gtggcgggca cctgtaatcc 229140 cagctactcg ggaggctgag gcaggaaaat cgcctgaacc cgggaggcgg aggttgcagc 229200 gagccaagat tgcgccactg cactccagcc tgggcgacaa gagcaagact ctgtctcaaa 229260 aaaaaaaaaa aaaaaaaagg atcttattta aagtctctgt ggacaataga tgtccttgct 229320 tgtgaagaac tggagacatt ggaaattgga actgcagccc cgagtggcca gcccaccaca 229380 tgccacagtc atggaatcac ccaggtgaga caagtcagcc cttgaatttc caggctgcca 229440 ttactcacag atgctcactg cctttcaaaa acctagagcc acttccaaat gcttggctgg 229500 gacttgaaga gaatcatccg tgacatacta gaacgaggtt tcttttaaat gtcaagatgc 229560 cataaaatga ttcaggccca tccttgaacc ttcagggtga gagctgagca gtcacaagcc 229620 cctttctggt ctttacatga atcacagaat ttcaaactgg aaggatcctt agaaattcgc 229680 cttctccaag ttcctgatgt cacagacgtg gagaccaagg gtggaggagg gcagaggctt 229740 tgctgaaatc tgcaggaatt ggtggcaggt tggggaccat agaatgtgtg tgtgtcttca 229800 tcctcagtcc aggacccgag tggacccctg gctcggggtc acatgtgtta aacagtagag 229860 ggtgtgtttt gttctgctgt tttgaggaga aggtgagtct ctttctgctt tgtcagatgg 229920 aagtctggac aattacttca tagcattcat tcatttgcca cacatattga ttaagggccc 229980 aatatgggac ccgaactgaa tcactgcagg agactttaga gcgaatattg tctaagacct 230040 ccaagtctgc ctggctgtga actatcctca gagcgacctg atttaagaat tcagattctg 230100 gctctcttcc ttggcgctgc ctatggaggg ggcagccatc tcctccttgg catcatggcc 230160 gccctcagac cccctgtgaa gcccaagatc atcaaaaaga gaaccaagaa gttcatccgg 230220 caccagtcag accgatgtgt cacgattaag cgtaactggc agaaacccag aggtattgac 230280 aacagggttg gtagaaggtt caagggccag atcttgatgc ccaacattgg ttatgggagc 230340 aacaaaaaaa caaagcacac gctgcccact ggcttctgga agttcagtct acaacgtcaa 230400 ggagctggaa gtgctgctga tgtacaacac ttcttactgc gctgagatcg ctcacagtgt 230460 ttcctccagg aaccgcgaag ccaccacaga aagagccgcc cagctggcca tcagagtcac 230520 tgacccccat gccagtctgc gcagtgaaga aaacgagcag acagctcatg tgcatgtttt 230580 gtgtttaaat aaaactgtaa aaactgcaaa aaaaaaaaaa tgcagattct gaatcccggt 230640 ctccctgctc cccgatctgg ggctctgggt tggaagctgg gcatcctgaa ttttagtttc 230700 ctgggcgatt ctgaccacct ggtgggtttg gacttcaacg tgctcactga caccttcgtt 230760 tagaatttca gatacgaaaa atggatttcc caaggtcaca cacgttatag gtgaggaaac 230820 tgagtctcac acagattcag tgggctttcc caggtcacag agctagttag ggatgaatgg 230880 gtttagcgtt gctgcttttc tgtaactgtg acttcctgca agagctgctg gaatgcagct 230940 gtctacagcc accggaggtg gggagcaagg tgacaaggca gaggacagga gtgattttgt 231000 tgccttcaga tgagaacggg gtcttcctaa gaccctgcat ccctgaagcc tctgctggta 231060 actgtgagga tagtctctgc caacagagag ggtgccctga gtttcaatag gagaattggc 231120 tccatggggt gtaataacca aacgaatgtg cggaatgaca atgatttaat cctgtagcct 231180 ttattaaagg cttgctttgt gctgggtgag aaaggtctgg gattgtattc ttcattctca 231240 ttttgaaagg aacacaaatg ccatcaagat tttgatatgg atggccacat gtgtctaagc 231300 cccggaaaac catcctgaga gatcaagacc atcttggcca ggatggtctt gaactcctga 231360 cctcatgatc cacccacctc agcctcccaa agtgctggga ttacaggcgt gcaccaccac 231420 gcctggcctc gttttattct tatttattta tttatttatt tatttatttt tgagatggaa 231480 tctcactctg tcacccaggc tggaatgcag tggtgtaatc tcggctcact gcaacctctg 231540 cctcccaggt tccagctctt ctcctgcctc agcctcccga gcagctgaga ctacagacgc 231600 acgccaccac gcccagctaa tttttgtatt tttattagag acggcgtttc accatgttgg 231660 ccaggctggt ctcgaactcc tgaactcgtg atccaccctc ctcggcttcc caaagggcta 231720 ggattatagg cgtgagccac ggtgccctgc ctacatttgg ttttatagtc caccttacac 231780 agttctctat acattgtaaa tgagccaaat ttcctgaatt gaaaaagaga gtcacacaag 231840 aggcttgcct ccacgcacag acatgtagtt ttagatgtct gcacgtgaag ctatatcaaa 231900 ataagaataa actactgcta ccaagaagtg ggaaaaaaat ttaaaaagga taaactgctc 231960 agaaaacgaa acagattaaa caaaaaattg tattagatga aatttttttt catcgaatct 232020 tgctccagac tcttcttctg ttgcttcaga cccttcttca tctgaagagt cttgctctgt 232080 ctcccaggct ggagtgcagt grcacgatct tggcccactg caacctccgc ctcccgggtt 232140 caagcaattc tcctgcctca gcctcctgag tagctgggat tacaggcgcg caccaccacg 232200 cccagctaat ttgtgtattt ttagtaggga cggggtttca ccatgttggc caggctggtc 232260 tcgatctctt gacctcgtga tctgcccgct tcggcctccc aaagtgctgg gattacaggc 232320 gtgagccacg gcgcccggcc tttcacttgg ttctctatga aaaaattaaa gagaaaatct 232380 gattgacact gtggaggaca ctacactcca aaaaaaaaag tactatattt tctaatatta 232440 tcagtgcttt ttaatatttt ctaatattat cagtgaagct tttgccgctt tttcaaaatc 232500 tggaagaaac aaggcggttg attcctttaa tttcaggagc atgtaacttc atttataatg 232560 acaatgtttt tgaaaaaata aattaaaccg acagtttcat ttgtaggatt gactttaata 232620 acacgcctct actgaacaaa tggcgattaa ctggggaaaa cggaattatg gtaaccgagg 232680 taacggggtc ggggactctt tctccttcgc tgcatgctgg gtggcgggga gagaccgctc 232740 tgaggaggtt tggtctgtcg gccacgccgt aggccgcggt gcattctggg tcctggcaat 232800 atggcgtcct ccttgatggg ctgatgagat gagtttcact gtagctccaa accagagggc 232860 aaagctccca tgacccaata agcccacatt gtccctttcc tccgtggttc cgtgtcgccc 232920 gtttctcagg actcgttctc aggcaggaga gagcctcggg gctgaaggcc aggaccagcc 232980 aggccgcgcg gacctgaggt tgaggaaccg ggtgcaggcg agcacgatgg gccggtcgtg 233040 gctctggttg cagcagctca gacgagtgcg ggacccgcag ggctgagagt ggctggagga 233100 gacccagggc cctttgaacc cgatcccttg gccggagacc tcagcccagt cggcccagtg 233160 ggcgaaccgg caccaagagc ggcctgcctg tcttcggaac tgctgaggcg gtggaggccg 233220 agagcagggt catcgtgagg cctgaagtct cttacgcttt tggcagctcc cctcgcagcc 233280 cctctggaaa cgtacagcct caggagcagc cagtggcttg ggacctgggg tggtgtgtgt 233340 ctgcggagct tcttgggctg ccccatttcc tagcggcccc cacctcccca cttcccgctc 233400 agagttagag ataaggatct cagacttttg cctgagtaag ggtctccgca ctctttatcc 233460 atttggtttt cgatttcccg tttttgtttc ttatttcacc aattctggta cacgctagtt 233520 tttaaggctg gaggttctcg agcgcttgct gccaaggact cccccacccc ctcccccact 233580 gatggagtcc gaaatgctgc aatcgcctct tctgggcctg ggggaggaag atgaggctga 233640 tcttacagac tggaacctac ctttggcttt tatgaaaaag aggcactgtg agaaaattga 233700 aggctccaaa tccttagctc agagctggag gatgaaggat cgggtaagtg gattctgaag 233760 gcaccccttg aacttggtag tttccccaac aaagaaagtt tacagcccga aaagtgtcct 233820 tgggaaagcg ccgacatttc cccctagcca cacgttgtaa gtcaactaga aagcaaaagc 233880 catttcagac tgcagttttt ggttgaaaat ggaaaatgct gttttggtta gtcattattc 233940 actgggtagt gttaattcaa ttccaactaa gttctaattc agataataaa agttaagcaa 234000 atttgaaaat agagcattgc gagtatttac atgctctttg gcatactact tagttctgta 234060 aacacttaga ggaaggacaa cgtgcgatat aatctttata cccacatgat tagtctactt 234120 tttaaaatat ccaagctggg tgaagtgcag aagtctgata tactatgcta ggaaatgaga 234180 ttactggaaa atgttcaact agtaacaaat tagtgcaaag ttattataaa gttacactga 234240 acttcattct agtcttctaa acaatttctc ttgaagctag attttcctcc ttttatgtag 234300 tgtcctgttg ctgtaacttg gaaacaggat ttctttaatc gtgagttagg gtatgaggcg 234360 tcgagacttg ggtgcaggtt ttagggtgtc cgcatggtgt ttggagtgtg gagagtgact 234420 cacaagcagc tggtaggaaa gaaaacagcc gaattttgtt ggatttgtcc ttcataaaac 234480 acccatctat ttcctggcct caaaagcaaa agggtagtac tgcttctcct ctatgcacac 234540 ttataatttg tctttttgta agttattttc tccctccagg ctgcttttat ttgcacattt 234600 cagtggtata aaagaggaag ttggtgttac aatgtttgat tttctctagg cttatgtata 234660 tgtttatgga atattattgt tttttagtat atgatgttga acatatataa gattacactt 234720 ctgggctggg cgcggtggct cacgcctgta atctcagcac tttgggaggc caaggcaggc 234780 ctcccaaagg caggcggatc acctgaggtc aggagtttga gaccagcccg gccaacatgg 234840 tgaaaccctg tctgtactaa aaatacaaaa attagctggg cttggtggca ggtgcccgta 234900 atcccagcta ctcgagaagc tgaggctgga gaatcgcttg aacctgggag gcagaggttg 234960 cagtgagccg aaatcgcacc attgcactcc agcctagggg 235000

Claims

뇌경색 미발증의 피험자 유래의 샘플에 있어서의 RNF213 p.R4810K 유전자 다형의 유무를 검출하는 검출 스텝과,
상기 검출 스텝에 있어서의 상기 RNF213 p.R4810K 유전자 다형의 유무와, 상기 피험자의 성별 정보에 기초하여 당해 피험자의 뇌경색 발증 확률을 판정하는 판정 스텝
을 포함하는, 뇌경색 발증 리스크를 예측하는 방법.
제 1 항에 있어서,
상기 검출 스텝에 있어서, 상기 RNF213 p.R4810K 유전자 다형이 검출된 경우, 상기 판정 스텝에 있어서, 상기 RNF213 p.R4810K 유전자 다형을 가지지 않는 자에 비하여, 당해 피험자는 뇌경색 발증의 리스크가 높은 것으로 판정하는, 뇌경색 발증 리스크를 예측하는 방법.
제 1 항 또는 제 2 항에 있어서,
상기 검출 스텝에 있어서, 상기 RNF213 p.R4810K 유전자 다형이 검출된 경우, 상기 판정 스텝에 있어서, 당해 피험자의 성별이 여성인 경우에는 남성의 경우에 비하여, 당해 피험자는 뇌경색 발증의 리스크가 보다 높은 것으로 판정하는, 뇌경색 발증 리스크를 예측하는 방법.
삭제
삭제