KR102525943B1 - A cosmetic composition for skin improvement comprising yeast extracts - Google Patents

Abstract

A cosmetic composition according to the present invention includes panthenol, which acts as a lubricant on the skin surface, a yeast extract, and polyphenol, and by stabilizing the active ingredients by placing the active ingredients inside niosome, the cosmetic composition improves the low feeling of use and moisturizing properties, which are the disadvantages of the active ingredients, and at the same time, has skin-improving effects such as cell detoxification, removal of skin wastes, increased skin cell lifespan, and anti-inflammatory properties.

Description

A cosmetic composition for skin improvement comprising yeast extracts as an active ingredient

The present invention relates to a cosmetic composition for skin improvement containing yeast extract as an active ingredient, and in detail, contains panthenol, yeast extract, and polyphenol to exhibit effects such as cell detoxification, skin waste removal, skin cell lifespan increase, anti-inflammation, and the like. It relates to a cosmetic composition for improving skin conditions.

The skin is the largest organ in humans and is also the first line of defense against the external environment. However, the skin is the outermost layer directly exposed to the external environment, and the activity of keratinocytes and fibroblasts is reduced by ultraviolet rays, stress, fine dust, and harmful chemicals, reducing the ability to hold water, weakening the skin barrier function, and causing external infections. It becomes sensitive to various stimuli due to the reduction of defense ability against Sensitized skin by external stimuli may have objective stimuli such as erythema and edema, as well as subjective inflammatory reactions such as itching, stinging, and burning. irritation may occur

Cosmetics are used to clean and beautify the body, protect the skin and keep it healthy. However, looking at cosmetic compositions, ingredients different from the original purpose of skin protection are used as essential entities for manufacturing and maintaining products. These ingredients include surfactants, preservatives, fragrances, sunscreens, and the like as ingredients that are indispensably added to preserve, maintain, and function cosmetics. These components are generally known as the main causes of skin irritation, inflammation, allergy, pimple, swelling, and the like.

Therefore, in terms of skin safety, cosmetics that reduce skin irritation and inflammation caused by various irritants are required, and the importance of irritation relieving materials that can protect the skin from various factors is increasing.

The skin is composed of three layers of epidermis, dermis and subcutaneous fat and surrounds the entire body. Among them, the epidermis consists of a basal layer, a spinous layer, a granular layer, and a stratum corneum. The stratum corneum, the outermost layer of the skin, is the outermost layer that is revealed in appearance and is very important cosmetically, showing physicochemical resistance to harmful external environments.

Epidermal cells undergo a differentiation process called keratinization, and the cells pass through the basal layer, the spinous layer, the granular layer, and the stratum corneum in turn and repeat the process of being eliminated as keratinocytes constituting the outermost layer. The keratin layer functions as an external barrier, and dead keratinocytes are eliminated from the skin and replaced with new keratinocytes. The keratinocytes in the flat form are connected to each other and remain strong and at the same time show flexibility as a whole. As the keratinocytes are continuously generated in turn and the oldest keratinocytes in the outermost layer are continuously eliminated, the epidermis always maintains a constant thickness. Although this turnover cycle varies depending on body parts, age, sex, health conditions, etc., the turnover cycle of the epidermis in normal skin is about 4 weeks. However, if this keratinization process is not normal, keratinocytes are excessively produced, resulting in thickening of the stratum corneum on the surface of the skin or roughening of the skin, making the skin dull, making it difficult to apply makeup, or making the overall look lifeless.

On the other hand, fair skin is closely related to water retention. Generally, the water content of the dermis is about 70%, but decreases as it goes to the epidermis, and is about 10 to 30% in the outermost layer. The water supplied from the dermis is mainly for passive diffusion. diffuses to the top of the stratum corneum and is lost to the outside.

Therefore, cosmetically, it is known that the water holding capacity of the stratum corneum is very important in maintaining smooth, flexible and beautiful skin. What is involved in the ability of the stratum corneum to hold water is called a natural moisturizing factor (NMF), and the flexibility of the stratum corneum is due to the action of NMF. These NMFs are known to include various amino acids, inorganic salts, pyrrolidone carbonic acid, and hydrophilic substances having water-retaining ability, such as lactate, and intercellular lipid components such as ceramide and oily components such as sebum.

However, despite the possession of the above-mentioned natural moisturizing factors, as the skin ages, the secretion of various hormones that control metabolism decreases and the function of immune cells and the activity of cells decrease. As the biosynthesis of proteins decreases, and harmful environmental factors such as harsh external environments, such as wind, cold or dry weather, increased ultraviolet radiation due to ozone layer destruction, excessive use of soap or detergent, and shaving, free radicals and As the production of harmful factors such as active free radicals increases, the function of the skin deteriorates due to excessive physical and chemical external stimuli and internal stimuli caused by stress, and thus the skin becomes rough and aging is further accelerated, resulting in damage gets worse

Accordingly, in recent years, there has been an increasing need for the development of new compositions for topical skin application that can deeply moisturize the skin without causing irritation, erythema, redness, etc. when applied to the skin.

Republic of Korea Patent Publication No. 10-2021-0046574 (April 28, 2021)

The present invention has been made to solve the above problems, and includes panthenol, which acts as a lubricant on the skin surface, and yeast extract and polyphenol therein, but stabilizes the active ingredient by locating the active ingredient inside the niosome. It is an object of the present invention to provide a cosmetic composition for skin improvement containing as an active ingredient yeast extract having skin improvement effects such as cell detoxification, skin waste removal, skin cell lifespan increase, and anti-inflammation while improving the low feeling of use.

The present invention relates to a cosmetic composition for skin improvement containing yeast extract as an active ingredient.

One aspect of the present invention is a cosmetic composition containing panthenol, yeast extract and polyphenol, wherein the active ingredient is located in the niosome and is stabilized. will be.

In the present invention, the niosome contains 0.1 to 30% by weight of panthenol with respect to 100% by weight in total, and the yeast extract is Candida Saitoana , Phaffia rhodozyma , Saccharomyces three Saccharomyces cerevisiae , Schizosaccharomyces pombe , Klureromyces lactis , Saccharomyces boulardii and Schizosaccharomyces ellipsoideus ( It is characterized in that it is obtained by culturing any one or a plurality of yeasts selected from Schizosaccharomyces ellipsoideus ).

In addition, the polyphenols are curcumin, resveratrol, quercetin, kaempferol, myricetin, luteolin, delchinidin, cyanidin, butane, ellagic acid, amphelopsin, hespiridine, aurantinidin, europinidin, pelagoni It includes any one or a plurality selected from deine, malvidin, peonidin, petunidin and rosinidin, and more specifically, the polyphenol is characterized in that it is a mixture of curcumin, resveratrol and quercetin.

In addition, the cosmetic composition is any selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays. It is characterized by having one or a plurality of formulations.

The cosmetic composition for skin improvement containing yeast extract as an active ingredient according to the present invention includes panthenol, which acts as a lubricant on the skin surface, and yeast extract and polyphenol therein, by stabilizing the active ingredient by locating the active ingredient inside the niosome. It improves the low feeling of use and moisturizing properties, which are the disadvantages of panthenol, and has skin improvement effects such as cell detoxification, skin waste removal, skin cell lifespan increase, and anti-inflammation.

Hereinafter, for examples and comparative examples, a cosmetic composition for skin improvement containing the yeast extract according to the present invention as an active ingredient will be described in more detail. However, the specific examples introduced below are provided as examples to sufficiently convey the spirit of the present invention to those skilled in the art.

Therefore, the present invention may be embodied in other forms without being limited to the specific examples presented below, and the specific examples presented below are only described to clarify the spirit of the present invention, but the present invention is not limited thereto.

At this time, if there is no other definition in the technical terms and scientific terms used, they have meanings commonly understood by those of ordinary skill in the art to which this invention belongs, and will unnecessarily obscure the gist of the present invention in the following description. Descriptions of possible known functions and configurations are omitted.

Also, the singular forms used in the specification and appended claims may be intended to include the plural forms as well, unless the context dictates otherwise.

In addition, the drawings introduced below are provided as examples to sufficiently convey the spirit of the present invention to those skilled in the art. Therefore, the present invention may be embodied in other forms without being limited to the drawings presented below, and the drawings presented below may be exaggerated to clarify the spirit of the present invention. Also, like reference numerals denote like elements throughout the specification.

In the present invention, the term 'external skin preparation' is a concept encompassing the overall composition applied to the skin, and includes, for example, various cosmetics such as basic cosmetics, makeup cosmetics, and hair cosmetics; It is a concept that includes pharmaceutical compositions applied externally to the skin, including pharmaceuticals and quasi-drugs such as ointments, creams, and lotions.

As described above, the inventor of the present invention, while conducting intensive research to develop a new composition for external application for skin that can deeply moisturize the skin without causing irritation, erythema, redness, etc. when applied to the skin, found anti-inflammatory, Attention was paid to panthenol, which has moisturizing, wound healing, skin protection, and skin soothing effects. Along with panthenol, yeast extract with skin whitening, anti-inflammatory, and antioxidant effects, and polyphenols with strong antioxidant effects were mixed. In order to compensate for the low feeling of use due to high viscosity, which is a disadvantage of active ingredients including epanthenol, the present invention was completed by improving the feeling of use by locating the active ingredient inside the niosome.

The cosmetic composition for skin improvement according to the present invention is characterized by containing panthenol, yeast extract and polyphenol.

In the present invention, the panthenol is an alcohol derivative of pantothenic acid (vitamin B5), also called provitamin B5, D-panthenol (Dexpanthenol), L-panthenol and D,L-panthenol, a mixture thereof. Pantothenic acid is a substance present in living cells and body tissues, and is known as an essential element for normal cell metabolism and hormone production.

In addition, the panthenol inhibits the activity of cyclooxygenase, which metabolizes prostaglandin and lukotriene, which are inflammatory mediators, and thus has excellent anti-inflammatory and anti-itch effects, and promotes cell growth as a non-stimulating moisturizer with penetration It has the function of keeping the skin moisturized, providing gloss to the skin mucous membrane, and preventing skin aging such as wrinkles, elasticity, and melasma.

However, in terms of formulation, D-panthenol is a highly viscous oil, and D,L-panthenol is in the form of a creamy white crystalline powder. In particular, D-panthenol has biological activity and is converted to pantothenic acid upon penetration into the skin for cell division. It promotes proliferation and is effective for skin regeneration, normalization of keratinization of the skin, wound healing, supply of moisture, and anti-inflammation. is placed so that the components of the niosome envelop the panthenol.

A delivery system for obtaining maximum effect by delivering an active ingredient to a desired area and preventing loss of unnecessary ingredients is continuously being studied, and liposomes are being studied a lot as such a delivery system. Liposomes are spherical vesicles surrounded by an inner aqueous phase with a phospholipid bilayer. Liposomes can encapsulate both polar and non-polar components and can increase the duration of action. Despite these advantages, storage and handling of the phospholipids used are difficult, and due to the disadvantages of high price, niosomes, which are similar to liposomes that form a double membrane using a nonionic surfactant, are widely used.

The niosome is a double-membrane transporter composed of nonionic surfactants, which can encapsulate polar and nonpolar components, is stable, and also has advantages in that it is easy to store and handle the surfactant used during manufacture, and also in terms of price. This double membrane is not spontaneously formed and requires energy such as physical agitation or heat. Liposomes composed of nonionic surfactants are called niosomes and are also called Nonionic Surfactant Vesicles (NSV).

The niosome is a vesicle based on a nonionic surfactant, and is similar in structure to liposome in terms of its bilayer structure, but is more stable than liposome due to the difference in components used to prepare niosome. In addition, niosomes can have a longer storage period than liposomes due to such stability, and have very low toxicity and biodegradability because they are formed as nonionic surfactants.

The niosome is not limited to a manufacturing method. In general, an emulsifier, such as a non-ionic surfactant, includes an auxiliary emulsifier, a stabilizer, and the like, and after heating and mixing these components, mixing and emulsifying the components to be placed inside the niosome, cooling and defoaming the desired form of niosome. can be obtained.

Specifically, the nonionic surfactant may include polyglycerin fatty acid ester. The nonionic surfactant is a component that forms the double layer of niosome, and in particular, polyglycerol fatty acid ester can be obtained by making polyglycerin by dehydration condensation of glycerin and then esterifying fatty acids. Polyglycerol fatty acid esters may have a wide range of hydrophile-lipophile balance (HLB) depending on the average degree of polymerization of polyglycerol acting as a hydrophilic group, the type of fatty acid acting as a lipophilic group, and the number of fatty acids bonded (degree of esterification).

Examples of the polyglycerol fatty acid ester include polyglyceryl-5 laurate, polyglyceryl-5 myristate, and polyglyceryl-5 oleate. ), polyglyceryl-5 stearate, polyglyceryl-6 behenate, polyglyceryl-10 caprate, polyglyceryl-10 laurate (polyglyceryl-10 laurate), polyglyceryl-5 oleate (polyglyceryl-5 oleate) and polyglyceryl-10 stearate (polyglyceryl-10 stearate), among which polyglyceryl-6 behenate or polyglyceryl Preference is given to using Lil-5 oleate.

The polyglycerin fatty acid ester is preferably 1 to 20% by weight, more preferably 2 to 10% by weight, based on 100% by weight of the total niosome-forming composition. If the content of the polyglycerin fatty acid ester is less than the above range, there may be a problem with the formation of niosomes, and if it exceeds the above range, there may be a problem in that the amount of panthenol trapped in the niosome is reduced due to an excess of membrane components. .

The auxiliary emulsifier is added to help form the vesicles of niosome, and examples thereof may include sodium stearoyl glutamate, sodium surfactin, and the like. In particular, sodium surpectin is a sodium salt of surfactin. Surfactin was first discovered in 1968 in a culture medium of Bacillus subtilis and can be obtained by fermentation under mild conditions. Surfactin has a unique structure that includes a hydrophilic cyclic peptide moiety composed of 7 amino acids and a hydrophobic hydrocarbon chain. Sodium surfactin has an emulsifying ability that is 3,000 times greater than that of lecithin, and forms niosomes together with polyglycerin fatty acid esters.

The auxiliary emulsifier is preferably included in an amount of 0.1 to 30% by weight, more preferably 1 to 5% by weight, based on 100% by weight of the total niosome-forming composition. If the auxiliary emulsifier is added below the above range, the formation of niosomes is not properly performed, and when the above range is exceeded, the vesicles of the niosome may become unstable.

The stabilizer has an effect of forming vesicles of a desired size and shape, and examples of such stabilizers include cholesterol, phytosterol, and glycerin. In particular, the cholesterol and phytosterol impart stability to the bilayer membrane of niosomes, helping to form more stable niosomes, and the glycerin increases the stability of niosomes and at the same time acts on the surface of niosomes to help deform force By giving, it has an effect of helping penetration into the skin.

The stabilizer may be included in 1 to 60% by weight, more preferably 10 to 40% by weight, based on 100% by weight of the total niosome-forming composition. When the stabilizer is added below the above range, the stabilizing effect of the niosome may be reduced, and when the above range is exceeded, the niosome may not be properly formed.

In addition, the niosome-forming composition may further include a solvent. At this time, the solvent mainly includes alcohol and water, and it is preferable to use butylene glycol as the alcohol. The composition ratio of the alcohol and water is not limited, and the total solvent is preferably included in a residual amount excluding the above components.

The production method of the niosome according to the present invention is not limited. For example, the emulsifier, co-emulsifier, stabilizer, and solvent are heated to 80 to 100 ° C. to dissolve them, and then wetted for 1 to 2 hours to stabilize them. After cooling to 30 to 40° C., panthenol, yeast extract, polyphenol, and additional stabilizers are added to emulsify the mixture. Then, the niosome according to the present invention can be obtained by passing it through a high-pressure homogenizer at about 1,000 bar 5 to 10 times in a row, followed by cooling and degassing.

The niosome does not limit the amount of panthenol added therein, but preferably contains 0.1 to 30% by weight of panthenol, more preferably 1 to 10% by weight, based on 100% by weight in total. When the added amount of panthenol is less than the above range, the overall effects such as cell detoxification, skin waste removal, skin cell lifespan increase, and anti-inflammation of the cosmetic composition are insufficiently achieved. The feeling of use may decrease.

In the present invention, the yeast extract is added to increase the effect of moisturizing and wrinkle improvement by promoting collagen production and fibroblast proliferation as well as skin whitening effect.

The yeast has been used for a long time, especially in the food field, it is known as a safe and nutrient-rich food raw material such as protein, minerals, and beta-glucan, and in cosmetics, beta-glucan or yeast extract, which form the cell wall of yeast, has a moisturizing function. It is used as a raw material having, and in the United States, it is used for purposes such as wound healing (burn, hemorrhoids).

The usefulness of yeast for skin has been studied since the 1970s, and studies that yeast helps in wound healing have continued [Goodson W, Hohn D, Hunt TK, Leung DY. Augmentation of some aspects of wound healing by a "skin respiratory factor", J. Sur. Res.1976 21:125~129, Crowe MJ, McNeill RB, Schlemm DJ, Greenhalgh DG, Keller SJ. Topical application of yeast extract accelerates the wound healing of diabetic mice. J Burn Care Rehabil. 1999 Mar-Apr;20(2):155-62.] It is known that yeast extract promotes wound healing through the process of enhancing the activity of fibroblasts and promoting the synthesis of collagen.

In addition, yeast reacts anaerobically or aerobically depending on the culture environment, stops growing when the environment is not good, and copes with harsh external environments through heterozygosity. Unlike other microorganisms, yeast is sensitive to external influences. When all organisms first perceive stress, a warning reaction against the stress appears and a physiological awakening reaction that mobilizes body resources appears. Based on the fact that physiological changes are stable due to the effect (Seyle, 1956), research is being conducted to produce and apply useful substances by stressing yeast.

As the yeast in the present invention, conventional yeast known in the art may be used. These yeasts can be used, such as Candida sp. , Saccharomyces sp. , Shizosaccharomyces sp. , and the like, more specifically, Candida Saitoana , Papia rhodozyma , Saccharomyces cerevisiae , Schizosaccharomyces pombe , Klureromyces lactis , Saccharomyces boulardi ( Saccharomyces boulardii ) and Schizosaccharomyces ellipsoideus ( Schizosaccharomyces ellipsoideus ) Any one or a plurality of yeasts selected from may be used.

More preferably, as the yeast , Candida Saitoana and Phaffia rhodozyma are exemplified.

The Candida cytoana stimulates autophagy, promotes the formation of lysosomes, purifies α-glucan active components, and detoxifies cells by removing modified cellular components (oxidized proteins and peroxidized lipids), lipofuscin It has the effect of blocking the accumulation of aggregates. In addition, the papia rhodojima contains astaxanthin as an active ingredient, so the skin improvement effect can be further enhanced.

The astaxanthin is a 3,3'-dihydroxy-β,β-carotene-4,4'-dione (3, As 3'-dihydroxy-β,β-carotene-4,4'-dione), it is a kind of carotenoid and is a scarlet pigment found in fish such as salmon and trout and crustaceans such as shrimp and crab. In the case of animals, since they do not have astaxanthin biosynthetic ability, they depend on food intake. In the case of farmed fish or crustaceans, the intake of astaxanthin-producing microorganisms through the food chain is limited, so astaxanthin must be added to the feed to produce products colored with astaxanthin. there is.

Astaxanthin is not only used for coloring fish or crustaceans, but also exhibits various physiological activities because it has strong antioxidant activity. In other words, protective effect against gastric ulcer, anticancer effect, anti-inflammatory effect, antidiabetic effect, corneal protection effect, muscle fatigue recovery effect, skin protection effect from ultraviolet (UVA), antihypertensive effect, anti-arteriosclerosis effect, etc. have been reported. , In addition to the immune enhancement and immunomodulatory capabilities, treatment effects for autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and Crohn's disease, prevention of Helicobacter pylori infection, and prevention of Salmonella infection have also been reported.

The yeast extract is not limited to a manufacturing method. Specifically, the yeast extract is first inoculated and cultured with the above-described yeasts in a medium containing saccharides, then each of the strains is centrifuged to cover the cells, ethanol is added thereto, and shaken at room temperature for a certain time. Then, the supernatant was taken by centrifugation again, and the process of adding ethanol to the remaining cell pellet and shaking was repeated to obtain an extract.

The yeast extract is not limited in the amount added, but is preferably added to have a content of 0.1 to 2% by weight based on 100% by weight of the total composition. When the yeast extract is added below the above range, the above-mentioned effects such as whitening and skin disease improvement are insignificant, and when added above the above range, yellow or red spots may occur due to deposition of skin pigment.

In the present invention, the polyphenol is intended to increase the antioxidant properties of the composition, and most of the components have antioxidant properties, anti-arteriosclerosis, anti-allergy, blood flow enhancement, capillary strengthening, hemorrhage prevention, blood pressure control, etc. and can further increase the lifespan of cells.

The polyphenols may be included without limitation as long as they are commonly used in the art, and examples thereof include curcumin, resveratrol, quercetin, kaempferol, myricetin, luteolin, delchinidin, cyanidin, butein , ellagic acid, amphelopsin, hespiridine, aurantinidin, europinidin, pelargonidin, malvidin, peonidin, petunidin, and rosinidin, and the like, which may be used alone or in combination of two or more. there is.

More preferably, a mixture of curcumin, resveratrol and quercetin may be included as the polyphenol. All of the above components have excellent antioxidant effects compared to other polyphenols, and when used in combination, the skin protection effect from the external environment, skin regeneration effect, and moisturizing effect can be further enhanced compared to when used alone.

Curcumin is the main component of curry, and the yellow color characteristic of curry is due to curcumin, a natural color substance, which is a kind of alkaloid derived from the root of a plant called turmeric or turmeric (Curcuma longa), which is one of the main ingredients. It has anti-tumor, antioxidant, anti-amyloid and anti-inflammatory effects, inhibits oxidative DNA damage and lipid peroxidation, and acts as a free radical scavenger.

The resveratrol (Resveratrol) is a type of stilbene, which is a polyphenol produced in plants thanks to an enzyme, stilbene synthase (STS), and exists as two structural isomers. It is found in many plants, including berries such as mulberries, peanuts, grapes, raspberries, and cranberries. It is a phytoalexin secreted when plants are stressed. In particular, grapes can protect themselves when attacked by fungi. It is found more than other plants because it secretes resveratrol, which has a strong antibacterial action as a defense substance. Resveratrol is known to have anticancer and strong antioxidant activities, and is known to play a role in lowering serum cholesterol.

The quercetin (Quercetin) is a flavonoid belonging to the polyphenol class, and is generally widely distributed in vegetables and fruits as glycosides of quercetin. It is usually bound to a sugar such as rutinose (quercetin-3-rutinoside) or glucose (isoquercetrin). It has excellent antioxidant effects including anti-hypertensive and anti-carcinogenic effects, lowers Th2-induced -IL4 expression in normal peripheral blood mononuclear cells, and is anti-inflammatory in animal models of asthma, a complex inflammation-related abnormality. Because it has a therapeutic effect, it has an excellent skin regeneration effect.

Although the composition ratio of the polyphenols is not limited, curcumin: resveratrol: quercetin is preferably added in a weight ratio of 1: 1 to 2: 1 to 5, respectively. When the composition ratio of polyphenols is out of the above range, especially when an excessive amount of one component is added, skin rash or yellowing may occur (curcumin) or acne may occur due to hormonal abnormalities (resveratrol).

The polyphenol is preferably added in an amount of 0.1 to 0.5% by weight based on 100% by weight of the total composition. If the content of polyphenol is less than the above range, the above-mentioned antioxidant, anti-arteriosclerosis, anti-allergy, blood flow enhancement, strengthening of capillaries, hemorrhage prevention, blood pressure control, etc. are insufficient, and the polyphenol content exceeds the above range In the case of acne, inflammation, erythema, etc. may occur.

The niosome may have a particle size of 10 to 200 nm, more preferably 100 to 150 nm. Since the gap between lipids in skin cells is 100 to 200 nm, niosomes having the same size are effective for percutaneous absorption.

The amount of the niosome added is not limited, but it is preferable to add the panthenol component in an amount of 1 to 10% by weight based on 100% by weight of the total composition. Similar to the content of panthenol in niosome, if it is less than the above range, the overall effects such as cell detoxification of the cosmetic composition, skin waste removal, skin cell life increase, anti-inflammatory effect are insufficiently achieved, and if it exceeds the above range, niosome The film of the cosmetic composition is weakened, and the feeling of use of the cosmetic composition may be deteriorated.

The cosmetic composition according to the present invention may be any formulation known as a cosmetic composition. For example, the cosmetic composition may be in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray. skin, emulsion, cream, sunscreen, foundation, essence, gel, pack, mask pack, foam cleanser, body cleanser, flexible lotion, eyeliner, shampoo, conditioner, soap, hairdressing agent, hair conditioner, and hair based on them. It can be included in creams, hair styling gels, lubricants, toothpastes, and wet wipes.

In addition, the cosmetic composition may further include various known additives within a range that does not impair the effect of the cosmetic composition according to the formulation as described above. Such additives include, for example, carriers, solvents, surfactants, emulsifiers, thickeners, conditioners, emollients, skin care ingredients, moisturizers, thickeners, lubricants, fillers, antioxidants, other preservatives, active ingredients, in particular dermatologically active ingredients. and flavoring agents.

Examples of the carrier include animal fibers, vegetable fibers, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, lactose, silica, aluminum hydroxide, calcium silicate, poly Amide powder, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, liquid diluent, ethoxylated isostearyl alcohol, Suspending agents such as polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonites, agar or tragacanth, aliphatic alcohol sulfates, aliphatic alcohol ether sulfates, sulfosuccinic acid monoesters, ise Thionates, imidazolinium derivatives, methyl taurates, sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated It may include glycerol fatty acid ester and the like, but is not limited thereto.

Examples of the surfactant include alkyl sulfates (eg, sodium lauryl sulfate, ammonium lauryl sulfate, and sodium cetearyl sulfate); alkyl sulfoacetates (eg sodium lauryl sulfoacetate); alkyl ether sulfates (eg sodium laureth sulfate, sodium tridecet sulfate, sodium oleth sulfate, ammonium laureth sulfate); alkyl ether sulfosuccinates (eg disodium laureth sulfosuccinate); alkyl glycosides (eg, decyl glucoside, lauryl glucoside); Alkyl isethionate amphoteric compounds (e.g. cocamidopropyl betaine, sodium cocoamphoacetate, sodium lauroamphoacetate, disodium lauroamphodiacetate, disodium cocoamphodiacetate, sodium lauroam porpripionate, disodium lauroamphodipropionate, potassium or ammonium salts of the aforementioned amphoteric compounds, capryl/capramidopropyl betaine, undecyleneamidopropyl betaine, lauromidopropyl betaine) and fatty alcohol poly Glycol ether etc. are mentioned.

These emulsifiers include salts of fatty acids, such as sodium stearate or sodium palmitate, organic soaps, such as mono-, di- or triethanolaminolate, sulfurized or sulfonated compounds, such as sodium lauryl sulfate or sodium cetyl. sulfonates), saponins, ramefons; cationic compounds (e.g. quaternary ammonium salts); nonionic compounds (e.g. fatty alcohols, fatty acid esters with saturated or unsaturated fatty acids, polyoxyethylene esters of fatty acids) or polyoxyethylene ethers, polymers from ethylene oxide and propylene oxide or propylene glycol), amphoteric compounds (e.g. phosphatides), proteins (e.g. gelatin, casein, alkylamidobetaines, alkyl betaines and amphoglyces) cinate), alkyl phosphates, alkylpolyoxyethylene phosphates or corresponding acids, silicone derivatives (eg, alkyl dimethicone copolyol), and the like.

Examples of the viscosity agent include fatty alcohols or fatty acid esters and mixtures thereof, such as acetylated lanolin alcohol, aluminum stearate, carbomer, cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl stearate (and) PEG 100 stearate, magnesium stearate, magnesium sulfate, oleic acid, stearic acid, stearyl alcohol, myristyl myristate, isopropyl palmitate, beeswax and its synthetic equivalents and carbomers; and the like.

The conditioner includes alkylamido ammonium lactate, cetrimonium chloride and distearoylethyl hydroxyethylmonium methosulfate and cetearyl alcohol, cetyl dimethicone, cetyl ricinoleate, dimethicone, laureth-23, laureth-4, polydecene, retinyl palmitate, quaternized protein hydrolysates, quaternized cellulose and starch derivatives, quaternized copolymers of acrylic acid or methacrylic acid or salts, quaternized silicone derivatives, and the like.

Examples of the softening agent include cetearyl isononanoate, cetearyl octanoate, decyl oleate, isooctyl stearate, coco caprylate/caprate, ethylhexyl hydroxystearate, ethylhexyl isononanoate, Isopropyl Isostearate, Isopropyl Myristate, Oleyl Oleate, Hexyl Laurate, Paraffinum Liquidum, PEG-75 Lanolin, PEG-7 Glyceryl Cocoate, Petrolatum, Ozokerite Cyclomethicone, Dimethicone , Dimethicone Copolyol, Dicaprylyl Ether, Butyrospermumparchy, Buxus Chinensis, Canola, Carnauba Sera, Copernicia Serifera, Oenothera Biennis, Elais ginensis, Prunus dulcis, squalane, zea may, glycine soya, helianthus annus, lanolin, hydrogenated castor oil, hydrogenated polyisobutene, sucrose cocoate, stearoxy dimethicone, lanolin alcohol, isohexadecane and the like.

Examples of the skin protection component include plant extracts, bisabolol, anti-inflammatory agents, urea, allantoin, panthenol and panthenol derivatives, phytantriol, vitamins A, E, C, D, animal or plant-derived ceramides and lecithin, and the like. .

Examples of the humectant include butylene glycol, cetyl alcohol, dimethicone, dimyristyl tartrate, glucose glycereth-26, glycerin, glyceryl stearate, hydrolyzed milk protein, lactic acid, lactose and other sugars, laureth-8, Lecithin, Octoxy Glycerin, PEG-12, PEG-135, PEG-150, PEG-20, PEG-8, Pentylene Glycol, Hexylene Glycol, Phytantriol, Polyquaternium-39 PPG-20 Methyl Glucose Ether, propylene glycol, sodium hyaluronate, sodium lactate, sodium PCA, sorbitol, succinoglycan, synthetic beeswax, tri-C14-15 alkyl citrate, starch and the like.

Examples of the thickener include acrylate/steareth-20 methacrylate copolymer, carbomer, carboxymethyl starch, sera alba, dimethicone/vinyl dimethicone crosspolymer, propylene glycol alginate, hydroxyethylcellulose, hydroxypropyl methyl cellulose, silica, silica dimethyl silylate, xanthan gum, hydrogenated butylene/ethylene/styrene copolymer, and the like.

The lubricant includes adipic acid, fumaric acid and its salts, benzoic acid and its salts, glycerin triacetate, sodium or magnesium lauryl sulfate, magnesium stearate, solid polyethylene glycol, polyvinylpyrrolidone, boric acid, mono-laurate or mono-palmitate, myristyl alcohol, cetyl alcohol, cetylstearyl alcohol, talc, calcium or magnesium salts of higher fatty acids, mono-, di- or triglycerides of higher fatty acids, polytetrafluoroethylene and the like.

Examples of the antioxidant include sulfite (e.g. sodium sulfite), tocopherol or a derivative thereof, ascorbic acid or a derivative thereof, citric acid, propyl gallate, chitosan glycolate, cysteine, N-acetyl cysteine + zinc sulfate, thiosulfate (e.g. sodium thiosulfate) and polyphenols.

In addition, the composition may include various active ingredients depending on the application site of the skin. Examples of such active ingredients include antimicrobial agents, anti-inflammatory agents, plant extracts, bisabolol, panthenol, tocopherol, anti-cut, anti-irritant or anti-dandruff actives, or anti-aging agents such as retinol and melibiose. can contain. Other suitable active agents are, for example, Medicago officinalis, Actinidia chinensis, allantoin, Aloe barbadensis, Anona cherimolia , Anthemis nobilis, Arachis hypogaea, Arnica Montana, Avena sativa, beta-carotene, bisabolol, Borago officinalis officinalis), butylene glycol, Calendula officinalis, Camellia sinensis, camphor, Candida bombicola, capryloyl glycine, Carica papaya, Centaurea cyanus, cetylpyridinium chloride, Chamomilla recutita, Chenopodium quinoa, Chinchona succirubra, Chondrus crispus), Citrus aurantium dulcis, Citrus grandis, Citrus limonum, Cocos nucifera, Coffea Arabica, Crataegus monogina, Cucumis melo, dichlorophenyl imidazoledioxolane, Enteromorpha compressa, Equsetum arvense, ethoxydiglycol, ethyl panthenol , farnesol, ferulic acid, Fragaria chiloensis, Gentiana lutea, Ginkgo biloba, glycerin, glyceryl laurate, Glycyrrhiza glabra , Hamamelis virginiana, heliotropin, hydrogenated palm glycerides, citrate, hydrolyzed castor oil, hydrolyzed wheat protein, Hypericum perforatum, Iris Florentina florentina), Juniperus communis, Lactis proteinum, lactose, Lawsonia inermis, linalool, Linum usitatissimum, ricin , magnesium aspartate, Magnifera indica, Malva sylvestris, mannitol, mel Melaleuca alternifolia, Mentha piperita, menthol, methyl Lactate, Mimosa tenuiflora, Nymphaea alba, Olaflur, Oryza sativa, Panthenol, Paraffinum Liquidum, PEG-20M, PEG-26 Jojoba Acid, PEG-26 Jojoba Alcohol, PEG-35 Castor Oil, PEG-40 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil, PEG-8 Caprylic/Capric Acid, Persea gratissima, Petrolatum, Potassium Asth Partate, Potassium Sorbate, Propylene Glycol, Prunus amygdalus dulcis, Prunus armeniaca, Prunus persica, Retinyl Palmitate, Ricinus communis (Ricinus communis), Rosa canina, Rosmarinus officinalis, Rubus idaeus, salicylic acid, Sambucus nigra, sarcosine, Serenois Serenoa serrulata, Simmondsia chinensis, Sodium Carboxymethyl Beta-Glucan, Sodium Cocoyl Amino Acid, Sodium Hyaluronate, Sodium Palmitoyl Praline, Stearoxytrimethylsilane, Stearyl Alcohol, Sulfurized TEA- Ricinoleate, talc, Thymus vulgaris, Tilia cordata, tocopherol, tocopheryl acetate, trideceth-9, triticum vulgaris, tyrosine, undecylenoyl glycine, urea, boxy and Vaccinium myrtillus, valine, zinc oxide, and zinc sulfate.

Hereinafter, the present invention will be described in more detail by way of Examples and Comparative Examples. However, the following examples and comparative examples are only examples for explaining the present invention in detail, and the present invention is not limited by the following examples.

The physical properties of the specimens prepared in Examples and Comparative Examples were measured as follows.

(skin irritation)

The first stimulation test on the human body was conducted on 50 healthy adult men and women according to the CTFA guidelines (The Cosmetic, Toiletry and Fragrance Association. Inc. Washington, D.C., 20036, 1991). After dropping 20 μl of each of the samples into the fin chamber, it was placed on the back of the human body as a test site and fixed with tape. Then, after applying the patch for 24 hours, the patch was removed. After 4 hours had elapsed after removing the patch, the skin reaction at the test site was judged according to the following criteria.

<Judgment Criteria>

－ : No erythema or unusual phenomenon

±: Slightly redder than the surroundings

+: Significantly redder than the surroundings

+++: More reddened and swollen than the surrounding area

Stimulation = [(± number × 1 + (+) number × 2 + (++) number × 3] / number of test subjects

(anti-inflammatory)

In order to confirm the anti-inflammatory sensory test on the human body, 10 subjects applied 2.0 mg/cm2 of the specimen twice a day for 7 days to the pimple area, respectively, and observed changes. Water was used as a control.

(Moisture retention ability)

After each sample was applied to the skin in a quantitative manner, the water retention of the stratum corneum was measured and evaluated. Moisturizing ability was measured using a skin surface hygrometer (model name: SKICON-200, manufactured by IBS, Japan). Specifically, in a constant temperature and humidity room at a temperature of 25 ° C and a relative humidity of 45, a certain amount (2 mg / cm 2) was applied to the inside of the arms of 20 test subjects, respectively, and then rubbed well. The moisturizing effect was evaluated by measuring the moisture increase rate (%) after 3 hours.

(Feeling of use)

The feeling of use of the prepared specimen was sensory evaluated for the subjects. The subjects were 20 adult women aged 30 to 50 years old, and after washing their face, after using only one swatch, the feeling of use was evaluated on a 5-point scale according to the evaluation criteria described below, and the evaluation was rounded off to the second decimal place.

<Evaluation Criteria>

Very good: 5

Good: 4

Normal: 3

Bad: 2

Very bad: 1

(Examples 1 to 6 and Comparative Examples 1 to 3)

First, the composition shown in Table 1 was prepared as a raw material to prepare a niosome containing an active ingredient. After melting polyglyceryl-6 behenate, ceteth-3, PEG-5 rapeseed oil sterol, cholesterol, and sodium stearoyl glutamate by heating to 90 ° C, glycerin and purified water were heated to 80 ° C to dissolve the composition. After addition, it was wetted again at 90°C for 1 hour and then cooled to 40°C again. Panthenol, yeast extract and polyphenol were added to the cooled composition and emulsified, and then passed through a high-pressure homogenizer at 1,000 bar 5 times in succession, followed by cooling and defoaming to obtain niosomes containing active ingredients.

At this time, Papia Rhodojima (ATCC 96594, A) strains, Saccharomyces cerevisiae (ATCC 18824, B) and Candida cytoana (IFO 0768, C) strains were each placed in a fermenter containing sugar water as yeast extracts. It was inoculated (added at 50,000 cfu/L), and culture was performed in a 5L fermenter at 30°C and pH 6 for 7 days. After the culture was completed, the yeast extract was obtained by aging for 30 days at 15° C. and 80% humidity, and only the supernatant was collected.

[Table 1]

Next, a lotion was prepared with the composition of Table 2, and the efficacy of the lotion was confirmed through the following evaluation method using the prepared lotion as a specimen. At this time, in Comparative Example 1, the lotion was prepared by mixing panthenol as it is without placing it inside the niosome.

[Table 2]

[Table 3]

As shown in Table 3, the cosmetic composition according to the present invention scored high in terms of skin irritation, anti-inflammatory property, moisture increase rate, and feeling of use. Specifically, Example 3 including curcumin, resveratrol, and quercetin as polyphenol components and Example 7 using Candida cytoana as yeast extract have higher anti-inflammatory effects than Examples 1, 2, 4, 5, etc., in which each component was partially excluded. It can be seen that it has moisturizing properties and low skin irritation.

Apart from this, Example 6 using the Saccharomyces cerevisiae extract as the yeast extract increased skin irritation and decreased anti-inflammatory properties, and Comparative Examples 1 to 3 missing panthenol, yeast extract and polyphenol components, respectively. It can be confirmed that all indicators have decreased compared to the examples.

In the above, preferred embodiments of the present invention have been described, but the scope of the present invention is not limited only to the specific embodiments as described above, and those skilled in the art can appropriately within the scope described in the claims of the present invention. change will be possible.

Claims (6)

Of the total 100% by weight, 1 to 10% by weight of panthenol, 0.1 to 2% by weight of Candida Saitoana as a yeast extract, and curcumin, resveratrol and quercetin as polyphenols in a weight ratio of 1: 1 to 2: 1 to 5, respectively A cosmetic composition containing 0.1 to 0.5% by weight of the mixed mixture, wherein the panthenol, yeast extract and polyphenol are stabilized by being located in the niosome.
delete delete delete delete According to claim 1,
The cosmetic composition is any one selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays. A cosmetic composition for skin improvement containing yeast extract as an active ingredient, characterized in that it has a formulation of.