KR102520049B1 - Cosmetic composition containing hydrogen nano bubble - Google Patents

Abstract

The present invention relates to a cosmetic composition containing hydrogen nanobubbles, which exhibits excellent effects in cleaning fine dust.
The hydrogen nanobubble-containing cosmetic composition of the present invention has an excellent fine dust cleaning effect, so it can be applied as a cosmetic composition for fine dust cleaning, and can help improve various diseases such as skin diseases caused by fine dust. .

Description

Cosmetic composition containing hydrogen nano bubbles {Cosmetic composition containing hydrogen nano bubbles}

The present invention relates to a cosmetic composition containing hydrogen nanobubbles, which exhibits excellent effects in cleaning fine dust.

Fine dust refers to dust with a diameter of 10 μm or less, and in foreign countries, fine dust (suspended particles) with a diameter of 10 μm or less (PM 10) is called, and dust with a diameter of 2.5 μm or less (PM 2.5) It is subdivided into dust that is less than 1 μm (PM 1), but in Korea, floating dust is called fine dust (PM 10) and fine dust is called ultrafine dust (PM 2.5), and PM 1 is also classified as ultrafine dust.

When exposed to fine dust for a long period of time, immunity is rapidly lowered, and respiratory diseases such as colds, asthma, and bronchitis may be exposed to various diseases such as cardiovascular diseases, skin diseases, and eye diseases. In particular, ultrafine dust with a diameter of 2.5 μm or less easily penetrates deep into the bronchi and lungs in the human body, attaching to the bronchi and lungs, and causing various diseases (PM 2.5 environmental standard setting study, National Institute of Environmental Research, 2006).

In order to cope with this, various countermeasures are being taken, such as wearing a mask, using an air purifier indoors, or using an insect screen to block fine dust, but the above method is not a complete response to fine dust.

Under this background, the present inventors have made various efforts to develop a detergent capable of effectively cleaning fine dust attached to the skin surface. As a result, the present invention by developing a cosmetic composition containing hydrogen nano bubbles and confirming its fine dust cleaning effect has been completed.

One object of the present invention is to provide a cosmetic composition for cleaning fine dust containing hydrogen nanobubble water.

Another object of the present invention is to provide a fine dust cleaning method.

A detailed description of this is as follows. Meanwhile, each description and embodiment disclosed in the present invention may also be applied to each other description and embodiment. That is, all combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be seen that the scope of the present invention is limited by the specific descriptions described below.

One aspect of the present invention for achieving the above object provides a cosmetic composition for cleaning fine dust containing hydrogen nanobubble water.

In the present invention, the term "fine dust" means dust having a diameter of 10 μm or less. It is known that when exposed to fine dust for a long period of time, immunity is rapidly lowered, and exposure to various diseases such as respiratory diseases such as colds, asthma, bronchitis, as well as cardiovascular diseases, skin diseases, and eye diseases is known.

In the present invention, the term "hydrogen nanobubble water" means water containing hydrogen nanobubbles. The "hydrogen nanobubble" means that it is produced by injecting hydrogen into the bubble after bubbled water to a nano size (less than 100 nm).

The average particle size of the hydrogen nanobubbles prepared in one embodiment of the present invention was 107.9 nm.

The hydrogen nanobubble water may include 6.75 billion to 6.4 billion hydrogen nanobubbles/mL, specifically 2.7 billion to 5.4 billion hydrogen nanobubbles/mL.

When the number of hydrogen nanobubbles is less than 2.7 billion/mL, the fine dust cleaning power is low, and the cleaning effect is weak, and when the number exceeds 5.4 billion/mL, the fine dust cleaning power may decrease.

In one embodiment of the present invention, after applying the fine dust analogue to pig skin, using the detergent of Example 2 containing 6.75 billion, 1.35 billion, 2.7 billion, 5.4 billion, and 6.4 billion hydrogen nanobubbles / mL As a result of washing for 0, 30, 45, and 60 minutes, and quantifying the cleaning power with the naked eye and the image j program, as the number of hydrogen nanobubbles increased from 675 million/mL to 5.4 billion/mL, 30 minutes, 45 It was confirmed that the relative cleaning power increased during washing for 60 minutes and 60 minutes (FIG. 3). Immediately after application, the measured value of image J was 50.469, but after washing for 60 minutes, it was 99.643, showing an increase in cleaning power of about 1.97 times. When 5.4 billion hydrogen nanobubbles were used, a 2.79-fold increase in cleaning power was shown after cleaning for 60 minutes compared to immediately after application (FIG. 3).

However, when the nanobubble number increased to 6.4 billion/mL, the image J measurement value of 60-minute washing decreased by 2.23 times (FIG. 3).

These results show that the cleaning power for fine dust mimics is the best when the number of hydrogen nanobubbles is 5.4 billion/mL (FIG. 6), and the optimal hydrogen nanobubble included in the hydrogen nanobubble water for the best cleaning effect It can be seen that the number is 2.7 billion to 5.4 billion/mL, specifically 5.4 billion/mL.

The cosmetic composition of the present invention may contain 0.0001 to 90% by weight of the hydrogen nanobubble water, specifically 40 to 90% by weight, and more specifically 75% by weight, based on the total composition. Not limited.

If the content is less than 40% by weight, it is undesirable because the original desired activity cannot be sufficiently achieved, and if it exceeds 90% by weight, it may be uneconomical because a clear increase in effect is not expected as much as the increased content.

The composition may include 40 to 90% by weight of hydrogen nanobubble water and 1 to 30% by weight of sodium C14-16 olefin sulfonate. Specifically, the composition contains 60% by weight of hydrogen nanobubble water to 90% by weight and 5 to 25% by weight of sodium C14-16 olefin sulfonate, more specifically, 75% by weight of hydrogen nanobubble water and 20% by weight of sodium C14-16 olefin sulfonate. However, it is not limited thereto.

In the present invention, the composition may be characterized in that it cleans the fine dust on the skin surface.

The cosmetic composition according to the present invention is a solution, external ointment, cream, foam, nutrient lotion, softening lotion, pack, softening water, emulsion, makeup base, essence, soap, liquid detergent (detergent), bath additive, sunscreen cream, sun oil , suspensions, emulsions, pastes, gels, lotions, powders, soaps, surfactant-containing cleansers, oils, powder foundations, emulsion foundations, wax foundations, patches and sprays.

In addition, the cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers formulated in general skin cosmetics, and as typical ingredients, for example, oil, water, surfactants, moisturizers, lower alcohols, A thickener, a chelating agent, a colorant, a preservative, a flavoring agent, and the like may be suitably blended, but are not limited thereto.

Cosmetically acceptable carriers included in the cosmetic composition of the present invention vary depending on the formulation.

When the dosage form of the present invention is an ointment, paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide or Mixtures of these may be used.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder or a mixture thereof may be used as a carrier component, and in particular, in the case of a spray, chloro propellants such as fluorohydrocarbons, propane/butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil may be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, fatty acid esters of glycerol, polyethylene glycol or sorbitan may be used. there is.

In the case where the formulation of the present invention is a suspension, liquid diluents such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohols, suspending agents such as polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.

When the formulation of the present invention is a detergent or soap, alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolyzates, isethionates, lanolin derivatives, aliphatic alcohols, vegetable oils, glycerol, sugars, etc. can be used

The cosmetic composition of the present invention includes adjuvants commonly used in the hydrogen nanobubble water, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic activators, preservatives, antioxidants, solvents, fragrances, fillers, blocking agents, pigments, and absorbents. and dyes and the like.

In the present invention, the formulation of the cosmetic composition may be a detergent, but is not limited thereto.

In the present invention, the cosmetic composition may include without limitation any raw material that is normally added to the detergent formulation, and in particular, any raw material capable of enhancing the fine dust cleaning effect of hydrogen nanobubble water may be included without limitation. .

For example, the cosmetic composition includes 1,2-hexanediol, octyldodeceth-16, butylene glycol, hippo, in addition to sodium C14-16 olefin sulfonate. Hamamelis Virginiana (Witch Hazel) Extract, Aloe BarbadensisLeaf Extract, Citric Acid, Citrus Reticulata (Tangerine) Peel Oil, Dios Dioscorea Japonica Root Extract, Caprylyl Glycol, Capryl hydroxamic Acid, Bowellia Serrata Resin Extract, Hydrolyzed Corn Starch Corn Starch), Beta-Glucan, Tremella Fuciformis (Mushroom) Extract, Sucrose and Disodium ethylenediaminetetraacetic acid (Disodium EDTA). It may further include any one or more raw materials selected from the group consisting of, but is not limited thereto.

The average particle size of the detergent containing hydrogen nanobubbles prepared in one embodiment of the present invention was 150.2 nm, which was greater than the particle size of hydrogen nanobubbles by mixing additives with hydrogen nanobubbles (FIG. 2).

In one embodiment of the present invention, the detergent containing hydrogen nanobubble water according to the present invention had a significantly smaller adsorption amount of fine dust and a significantly higher improvement rate of fine dust compared to soap as a control group when applied to the human body. In particular, after cleaning once using a fine dust analog sample, the detergent containing hydrogen nano bubble water of the present invention showed an improvement rate of 82.4%, and it was confirmed that it had 2.04 times the fine dust cleaning power compared to soap (Table 2 and Fig. 6).

In addition, since no specific adverse events were observed or reported at the site where the hydrogen nanobubble water-containing detergent was used by all subjects, the cosmetic composition including the hydrogen nanobubble-containing detergent according to the present invention has excellent stability to the skin and cleans fine dust The effect was confirmed to be significant.

Another aspect of the present invention provides a fine dust cleaning method.

Terms used herein are as described above.

The method includes the steps of a) preparing a composition containing hydrogen nanobubble water; And b) treating the prepared composition to the skin; may include, but is not limited thereto.

Step a) may be to prepare a composition containing hydrogen nanobubble water.

The hydrogen nanobubble water may be produced by bubbling water to a nano size (less than 100 nm) and then injecting hydrogen into the bubbles to produce hydrogen nanobubbles or by generating hydrogen in water using a hydrogen generator. , Any method for producing hydrogen nanobubble water known in the art may be used without limitation.

In one embodiment of the present invention, after bubbles in water to a nano size (100 nm or less), hydrogen is injected into the bubbles to produce hydrogen nanobubbles, or hydrogen is generated in water using a hydrogen generator. The average particle size of the hydrogen nanobubbles prepared in one embodiment of the present invention was 107.9 nm.

The hydrogen nanobubble water may contain 2.7 billion to 5.4 billion hydrogen nanobubbles/mL.

The composition of step a) may be prepared by adding raw materials commonly added to detergent formulations to the prepared hydrogen nanobubble water.

In one embodiment of the present invention, a detergent was prepared by mixing 20% by weight of sodium C14-16 olefin sulfonate with 75% by weight (100mL) of hydrogen nanobubble water. 2-Hexanediol, Octyldodeceth-16, Butylene Glycol, Hamamelis Virginiana (Witch Hazel) Extract, Aloe barbaden Aloe BarbadensisLeaf Extract, Citric Acid, Citrus Reticulata (Tangerine) Peel Oil, Dioscorea Japonica Root Extract, Caprylyl Glycol , Capryl hydroxamic acid, Bowellia Serrata Resin Extract, Hydrolyzed Corn Starch, Beta-Glucan, Tremella Pushformis At least one raw material selected from the group consisting of Tremella Fuciformis (Mushroom) Extract, Sucrose, and Disodium ethylenediaminetetraacetic acid (Disodium EDTA) may be further included, but is limited thereto It doesn't work. The raw materials may be added to the detergent in any concentration and amount as desired by those skilled in the art.

Step b) may be to treat the prepared composition to the skin.

The treatment may be foaming with the composition, rubbing the contaminated area, and then wiping and washing with running water, but is not limited thereto.

In one embodiment of the present invention, after foaming with the composition and rubbing the contaminated area 5 or more times, it was washed with running water 3-4 times or more.

The hydrogen nanobubble-containing cosmetic composition of the present invention has an excellent fine dust cleaning effect, so it can be applied as a cosmetic composition for fine dust cleaning, and can help improve various diseases such as skin diseases caused by fine dust. .

1 is the particle size of hydrogen nanobubbles according to the present invention.
2 is the particle size of the hydrogen nanobubble-containing detergent according to the present invention.
3 shows cleaning results according to the number of hydrogen nanobubbles and digitized results with the image j program.
4 is a schematic diagram showing a method for partitioning a test site of a subject.
Fig. 5 shows the cleaning results of each test group performed by subjects 3 to 5.
6 is a graph showing the fine dust adsorption amount and improvement rate.

Hereinafter, the present invention will be described in more detail by examples. However, these examples are intended to illustrate the present invention by way of example, and the scope of the present invention is not limited by these examples, and will be clear to those skilled in the art to which the present invention belongs.

Example 1. Hydrogen Nanobubble Water Preparation

After bubbling water into nano-sized bubbles (less than 100 nm), hydrogen was injected into the bubbles to produce hydrogen nanobubbles, or hydrogen was generated by generating hydrogen in water using a hydrogen generator.

The average particle size of the prepared hydrogen nanobubbles was 107.9 nm, and the number was about 5.4 billion per 1 mL of water (FIG. 1).

Example 2. Preparation of Detergent Containing Hydrogen Nanobubbles

20% by weight of Sodium C14-16 Olefin Sulfonate, 1,2-hexanediol, Octyldodeceth-16, Butylene Glycol, Hamamelis Virginiana (Witch Hazel) Extract, Aloe Barbadensis Leaf Extract, Citric Acid Acid), Citrus Reticulata (Tangerine) Peel Oil, Dioscorea Japonica Root Extract, Caprylyl Glycol, Capryl hydroxamic Acid, Bowellia Serrata Resin Extract, Hydrolyzed Corn Starch, Beta-Glucan, Tremella Fuciformis (Mushroom) Extract, Sucrose (Sucrose) and disodium ethylenediaminetetraacetic acid (Disodium EDTA) were added and mixed to prepare a detergent. The average particle size of the prepared detergent was 150.2 nm, and it can be seen that the particle size of the hydrogen nanobubbles is greater than that of the hydrogen nanobubbles due to the additive being mixed with the hydrogen nanobubbles (FIG. 2).

Example 3. Detergency test of hydrogen nanobubble-containing detergent

3-1. The optimal number of hydrogen nanobubbles included in the hydrogen nanobubble water

Fine dust analogues (carbon mesoporous, black cream) with the size of fine dust particles were applied to pig skin cut to the same size.

The detergent of Example 2 containing 6.75 billion, 1.35 billion, 2.7 billion, 5.4 billion, and 6.4 billion hydrogen nanobubbles/mL was stirred at 100 rpm for 10 minutes, rubbed 5 times back and forth evenly by hand, and then washed for 30 minutes. , and gently washed at 100 rpm for 45 and 60 minutes. The unwashed control was indicated immediately after application (0 min).

The degree of cleaning was observed with the naked eye, or the cleaning power for each cleaning time was quantified as a relative ratio to the cleaning power immediately after application (0 minutes) using the image j program.

As a result, as the number of hydrogen nanobubbles increased from 675 million/mL to 5.4 billion/mL, relative cleaning power increased during 30, 45, and 60 minute cleaning (FIG. 3).

In addition, when the number of hydrogen nanobubbles was 675 million/mL, the measured value of image J was 50.469 immediately after application, but after washing for 60 minutes, it was 99.643, showing an increase in cleaning power of about 1.97 times. When 5.4 billion hydrogen nanobubbles were used, a 2.79-fold increase in cleaning power was shown after cleaning for 60 minutes compared to immediately after application (FIG. 3).

However, when the nanobubble number increased to 6.4 billion/mL, the image J measurement value of 60-minute washing decreased by 2.23 times (FIG. 3). These results show that the cleaning power for fine dust mimics is the best when the number of hydrogen nanobubbles is 5.4 billion/mL.

Accordingly, it can be seen that the optimum number of hydrogen nanobubbles included in the hydrogen nanobubble water is 2.7 billion to 5.4 billion/mL for the best cleaning effect, and in the following examples, hydrogen nanobubbles containing 5.4 billion/mL Experiments were conducted with hydrogen nanobubble water.

3-2. Comparison of cleaning power

The cleaning power was confirmed for 21 Korean women aged 20 to 60 years old as subjects. The average age of 21 subjects was 44.5 years old, and the skin types were neutral in 5 (24%) and dry in 15 (76%).

A certain area (3x3cm) for each sample (detergent containing hydrogen nanobubble water containing 5.4 billion / mL of hydrogen nanobubbles (Example 2), control group (soap: light pink solid phase), blank test group (water)) was divided (FIG. 4), and the fine dust analogue was quantified (2 μl/cm ² ) and the subject applied the same to the test site (inner side of the subject's lower arm) using a finger wearing a thimble.

Each sample was used once to clean the test site. The detergent of Example 2 was put in a plastic pumping container, pumped twice, rubbed the test site 5 times, and then washed with running water 3-4 times. For the control group, soap bubbles were made with wet hands, rubbed the test site 5 times, and then washed with running water 3-4 times. The blank test group was washed by rubbing the test site 5 times with water on their hands and wiping it 3-4 times under running water.

After washing, the cleaning power was measured and evaluated after waiting for more than 15 minutes in a constant temperature and humidity room (22 ± 2 ° C, 50 ± 10%) to stabilize the skin. After imaging the test site using VISIA (VISIA complexion analysis system, Canfield, USA), color (intensity) was analyzed using an image analysis program (Image Pro+).

As shown in Table 1 and FIG. 5 below, the color parameter representing skin color brightness immediately after contaminating the test site using fine dust analogues significantly decreased in all test groups, and significantly increased after washing once using the sample. did

In addition, as shown in Table 2 and FIG. 6, the fine dust adsorption amount of Example 2 (fine bubble cleanser) was significantly smaller than the control soap, and the fine dust improvement rate was significantly high.

After cleaning once using the fine dust analog sample, Example 2 showed an improvement rate of 82.4%, and it was found that there was 2.04 times the fine dust cleaning power compared to soap.

Example 4. Subject questionnaire and skin reaction confirmation

4-1. subject questionnaire

After cleaning in Example 3-2, subjects were asked to fill out an efficacy questionnaire for the cleaning agent in Example 2. The questionnaire was written on a 5-point scale of 1 (not at all), 3 (normally), and 5 (very much), and the result analysis was calculated by the proportion of subjects who answered positively (from 4 to 5).

As a result, as shown in Table 3 below, it was confirmed that the detergent of Example 2 foamed well, the foam was maintained for a long time without extinguishing, and the moistness was maintained after use.

4-2. Check skin reaction

As a result of confirming the test site of the subject after washing in Example 3-2, no specific adverse event was observed or reported at the sample use site in all 21 subjects.

According to the above results, it was confirmed that the hydrogen nanobubble-containing detergent according to the present invention has excellent fine dust cleaning power compared to soap.

From the above description, those skilled in the art to which the present invention pertains will be able to understand that the present invention may be embodied in other specific forms without changing its technical spirit or essential features. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not limiting. The scope of the present invention should be construed as including all changes or modifications derived from the meaning and scope of the following claims and their equivalent concepts rather than the detailed description above.

Claims (6)

A cosmetic composition for cleaning fine dust containing hydrogen nanobubble water,
The hydrogen nanobubble water is a cosmetic composition comprising 2.7 billion to 5.4 billion hydrogen nanobubbles / mL.
The composition according to claim 1, wherein the hydrogen nanobubble water is water containing hydrogen nanobubbles prepared by injecting hydrogen into bubbles after bubbled water to a size of 100 nm or less.
delete The composition of claim 1, wherein the composition comprises 60 to 90% by weight of hydrogen nanobubble water and 1 to 30% by weight of sodium C14-16 olefin sulfonate.
The method of claim 4, wherein the composition is 1,2-hexanediol (1,2-Hexanediol), octyldodeceth-16 (Octyldodeceth-16), butylene glycol (Butylene Glycol), Hamamelis virginia extract (Hamamelis Virginiana (Witch Hazel) Extract, Aloe BarbadensisLeaf Extract, Citric Acid, Citrus Reticulata (Tangerine) Peel Oil, Dioscorea Japonica Root Extract), Caprylyl Glycol, Capryl hydroxamic Acid, Bowellia Serrata Resin Extract, Hydrolyzed Corn Starch, Beta-Glucan (Beta-Glucan), Tremella Fuciformis (Mushroom) Extract, any one selected from the group consisting of sucrose and disodium ethylenediaminetetraacetic acid (Disodium EDTA) A composition that further comprises the above.
a) preparing a composition containing hydrogen nanobubble water; and
b) treating the prepared composition to the skin; as a fine dust cleaning method comprising,
The hydrogen nanobubble water is characterized by containing 2.7 billion to 5.4 billion hydrogen nanobubbles / mL, fine dust cleaning method.

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