KR20230169651A - Cosmetic composition with oxygen nano bubble water and peptide complex - Google Patents

Abstract

The present invention relates to a cosmetic composition containing oxygen nanobubble water and a peptide complex. The cosmetic composition provided by the present invention can be effectively delivered to the skin, increase skin absorption rate, and provide a cosmetic composition with excellent moisture and moisturizing properties.

Description

Cosmetic composition containing oxygen nanobubble water and peptide complex {COSMETIC COMPOSITION WITH OXYGEN NANO BUBBLE WATER AND PEPTIDE COMPLEX}

The present invention relates to a cosmetic composition containing oxygen nanobubble water and a peptide complex, and specifically relates to a cosmetic composition containing oxygen nanobubble water and a peptide complex to improve skin absorption and provide excellent moisture and moisturizing sensation.

Due to the structure of the skin, when the moisture in the stratum corneum decreases, the skin becomes dry, the surface becomes rough, the skin loses its luster, appears dull, and other signs of skin aging occur. Moisturizing the skin is important to express healthy and elastic skin. In order to manage skin's moisture, various moisturizers are being released on the market that use moisture-absorbing properties, properties that prevent moisture evaporation, or methods that increase moisture retention.

The skin is composed of the epidermis, dermis, and subcutaneous fat. In particular, the epidermis is the outermost layer of the skin composed of epithelial tissue and consists of a total of five layers. Specifically, from the bottom, it is composed of a basal layer, spinous layer, granular layer, clear layer, and horny layer, and the stratum corneum present in the outermost layer is a variety of substances derived from the external environment. It acts as a primary defense shield by blocking compounds and stimuli. Therefore, there is a problem that transdermal delivery of skin-effective substances or physiologically active substances cannot be sufficiently achieved due to the barrier function of the stratum corneum.

Recently, in order to solve this problem, permeation accelerators have been used to weaken the barrier function of the stratum corneum by changing the structure of the stratum corneum. However, permeation accelerators are highly toxic to skin cells and have a very high possibility of causing skin irritation. has Accordingly, attempts are being made to increase delivery efficiency by using physical stimulation sources such as ultrasound, LED, and microcurrent, but the delivery effect is not predictable. Accordingly, there is a need to develop a method that can effectively achieve transdermal delivery of skin-effective substances or bioactive substances.

Accordingly, the present inventor developed a cosmetic composition containing oxygen nanobubble water and a peptide composite material that improves skin absorption rate and enables effective transdermal delivery of bioactive substances, leading to the present invention.

Korean Patent Publication No. 10-2021-0087397

The present invention seeks to provide a cosmetic composition containing oxygen nanobubble water and a peptide complex that improves skin absorption and provides excellent moisture and moisturizing effects.

However, the technical problem to be achieved by the present invention is not limited to the problems mentioned above, and other problems not mentioned can be clearly understood by those skilled in the art from the description below.

According to one embodiment of the present invention, a cosmetic composition containing oxygen nanobubble water and a peptide complex is provided.

In the present invention, the oxygen nanobubble water may be a cosmetic composition characterized in that it contains more than 30 ppm of oxygen.

In the present invention, the nanoparticles of the oxygen nanobubble water may be a cosmetic composition of 150 nm or less.

In the present invention, the peptide complex may be a cosmetic composition characterized by comprising acetyl hexapeptide.

In the present invention, the peptide complex may be included in a cosmetic composition in an amount of 0.001 to 0.5% by weight based on the total weight of the cosmetic composition.

In the present invention, the cosmetic composition may be a cosmetic composition further containing caffeic acid.

The cosmetic composition provided by the present invention contains oxygen nanobubble water and peptide composite materials to improve skin absorption rate, thereby providing excellent moisture and moisturizing effects, as well as effective transdermal delivery of skin-effective substances or bioactive substances. .

Hereinafter, in order to explain in more detail, examples will be given in detail. However, the following examples are illustrative and the scope of the present invention is not limited thereto.

According to one embodiment of the present invention, it relates to a cosmetic composition containing oxygen nanobubble water and a peptide complex.

In the present invention, the cosmetic composition may further include a skin-effective substance or a physiologically active substance, and the skin-effective substance or a physiologically active substance may be a commonly used skin-effective substance or a physiologically active substance.

For example, the skin efficacious substance or the physiologically active substance may be for whitening, skin elasticity, wrinkle improvement, moisture, moisturizing, anti-aging, anti-atopy, and UV protection, and may include vitamin A, vitamin C, vitamin E, and asbestos. Any one selected from tarzanthin, coenzyme Q10, arbutin, salicylic acid, kojic acid, alpha-lipoic acid, ellagic acid, resvera, oil-soluble licorice extract, docosahexaenoic acid, eicosapentaenoic acid, linoleic acid, glutathione, and caffeic acid. It may be more than this, but is not limited thereto.

In the present invention, the term “oxygen nanobubble water” refers to water containing oxygen nanobubbles. The “oxygen nanobubble” refers to a product manufactured by bubbles of water into nano-sized bubbles and then injecting oxygen into the bubbles.

In the present invention, oxygen (Oxygen) contained in the oxygen nanobubble water is an essential substance for the survival of aerobic organisms, including humans. Humans supply oxygen not only through the nose and mouth, but also through the skin, and skin respiration accounts for about 0.6% of total respiration. Skin respiration performs functions such as skin heat dissipation, toxic substances (skin toxins) excretion, moisture evaporation, and skin metabolism.

When oxygen deficiency occurs in the skin, it can cause inhibition of skin respiration or metabolic processes, and as a result, insufficient moisture replenishment within skin cells inhibits skin cell turnover, causing melanin to accumulate and not be discharged smoothly, causing blemishes or freckles. , may cause hyperpigmentation such as moles.

When using a cosmetic composition containing oxygen nanobubble water according to the present invention, the metabolic process of the skin can be improved by enhancing moisture replenishment within skin cells, and thus skin elasticity and whitening effects can be achieved. In addition, the skin absorption rate of the cosmetic composition can be improved, thereby enabling effective transdermal delivery of skin-effective substances or physiologically active substances.

The oxygen nanobubble water of the present invention may contain 30 ppm or more of oxygen, and is preferably 30 ppm to 120 ppm of oxygen in terms of increasing the skin absorption rate of the cosmetic composition, improving the skin barrier, and improving functionality such as skin moisturizing effect. It may be a cosmetic composition characterized in that it contains.

For example, if the oxygen concentration of the oxygen nanobubble water is less than 30ppm, the effect of improving skin absorption rate may not occur, and if it exceeds 120ppm, the problem of skin irritation due to a large amount of oxygen may occur. there is.

The average size of the nanoparticles of the oxygen nanobubble water of the present invention may be 30 nm to 150 nm, and is preferably 50 nm to 100 nm in terms of improving the skin absorption rate of the cosmetic composition. .

For example, when the nanoparticles of the oxygen nanobubble water are less than 30 nm, the size of the particles is significantly small, making it difficult to maintain the oxygen nanobubbles in the cosmetic composition, or forming bonds with the peptide complex or other components. Problems that make it difficult to do so may occur, and if it exceeds 150 nm, a problem may occur in which the cosmetic composition is not effectively absorbed into the skin.

In the present invention, the oxygen nanobubble water may be included in an amount of 60 to 98% by weight, 65 to 97% by weight, or 70 to 96% by weight based on the total weight of the cosmetic composition, and is suitably used in terms of enhancing skin absorption of the cosmetic composition. The cosmetic composition may contain 75 to 95% by weight, but is not limited thereto.

In the present invention, the peptide may refer to a polymer composed of one or more amino acids linked by amide bonds (or peptide bonds), and is manufactured according to chemical synthesis methods known in the art, especially solid-phase synthesis techniques. It can be.

The peptide complex may refer to a peptide complex that exhibits improvement effects on biosafety, skin activity, skin wrinkles, skin elasticity, skin texture, skin moisture, and moisturizing sensation.

The peptide complex of the present invention may contain a hexapeptide, and may be a cosmetic composition characterized by containing acetylhexapeptide, suitably in terms of stably delivering skin effective substances or physiologically active substances to the dermal layer. .

For example, the hexapeptide refers to a hexapeptide having the amino acid sequence of Glu-Glu-Met-Gln-Arg-Arg, and the hexapeptide may be one in which the carboxyl group at the C-terminus of the hexapeptide is replaced with an amide group, The amide group may be any one amide group selected from the group consisting of primary, secondary and tertiary amide groups, but is not limited thereto.

For example, the acetyl hexapeptide may include acetyl hexapeptide-8, which is a reaction product of acetic acid and hexapeptide-8. Specifically, acetyl hexapeptide-8 has the formula 1 below: It may include the structure (Ac- Glu-Glu-Met-Gln-Arg-Arg -NH2).

[Formula 1]

.

The acetylhexapeptide-8 interferes with the secretion of acetylcholine or neurotransmitter signals sent by the brain, thereby reducing existing wrinkles and suppressing newly formed wrinkles naturally and safely. It is not only effective in preventing wrinkles, but also promotes collagen and It can be effective in improving skin elasticity and texture by suppressing elastin damage. In addition, when used with a formulation with a high moisture content as a water-soluble ingredient, skin absorption rate is improved, resulting in excellent moisture and moisturizing effects.

The peptide complex of the present invention may be included in an amount of 0.001 to 0.5% by weight, 0.005 to 0.3% by weight, or 0.007 to 0.1% by weight, based on the total weight of the cosmetic composition, and is used to effectively and stably deliver the cosmetic composition to the skin. In terms of suitability, it may be a cosmetic composition containing 0.01 to 0.05% by weight.

For example, when the peptide complex is included in an amount of less than 0.001% by weight based on the total weight of the cosmetic composition, the skin absorption rate of the cosmetic composition may be significantly lowered, which may impede the effect of moisture and moisturizing sensation, or may inhibit skin-effective substances or physiological activities. Problems may arise in which the substance is not effectively delivered to the skin, and if it contains more than 0.5% by weight, skin irritation may occur.

The cosmetic composition of the present invention may be a cosmetic composition further containing caffeic acid.

In the present invention, caffeic acid is found in all plants. It is an organic compound classified as hydroxycinnamic acid and consists of a phenol group and an acrylic group. The organic compound is lignin, the main source of biomass. (lignin) may be an important intermediate in biosynthesis. In addition, the caffeic acid may have strong antioxidant activity in vitro and in vivo, may have immunomodulatory and anti-inflammatory effects, and may have sebum reduction, acne prevention and improvement effects.

For example, the caffeic acid may be included in an amount of 0.001 to 0.5% by weight, 0.005 to 0.3% by weight, or 0.01 to 0.2% by weight, based on the total weight of the cosmetic composition, and is suitable as a skin efficacious substance or antioxidant or sebum improvement. It may be included in an amount of 0.01 to 0.1% by weight.

In the present invention, the cosmetic composition may further include a ceramide complex.

In the present invention, the cosmetic composition may be for skin moisture or moisturizing, whitening, skin texture improvement, elasticity improvement, wrinkle improvement, UV protection, antioxidant or sebum improvement.

As used herein, the term "cosmetic composition" refers to an article used on the human body to clean and beautify the human body, add attractiveness, brighten the appearance, or maintain or promote the health of skin and hair.

The cosmetic composition may be a cosmetic composition containing at least one selected from the group consisting of a thickener, preservative, stabilizer, solubilizer, surfactant, carrier, and incense agent, as long as it does not impair the purpose of the present invention, and Other ingredients and functional ingredients that are blended in ordinary cosmetics can also be additionally blended.

The type of the cosmetic composition is not particularly limited, but suitable examples include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutritional lotion, massage cream, nutritional cream, moisture cream, hand cream, foundation, It can be selected from the group consisting of essence, nutritional essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, and body cleanser, and can be selected from the group consisting of external skin preparations, quasi-drugs, and pharmaceutical compositions for antibacterial or moisturizing purposes. It can be any one of them.

The external skin agent may be a cream, gel, ointment, skin emulsifier, skin suspension, transdermal delivery patch, drug-containing bandage, lotion, or a combination thereof. The skin external preparations include ingredients commonly used in external skin preparations such as cosmetics and medicines, such as aqueous ingredients, oil-based ingredients, powder ingredients, alcohols, moisturizers, thickeners, ultraviolet absorbers, whitening agents, preservatives, antioxidants, surfactants, and fragrances. , colorants, various skin nutrients, or a combination thereof may be appropriately mixed according to need.

The skin external preparations include metal sequestrants such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid, caffeine, tannin, belafamil, licorice extract, glablidin, and calin. Hot water extract of fruit, various herbal medicines, drugs such as tocopherol acetate, glytylitinic acid, tranexamic acid and its derivatives or salts, vitamin C, magnesium ascorbate phosphate, ascorbate glucoside, arbutin, kojic acid, glucose, fructose, Sugars such as trehalose can also be appropriately mixed.

Hereinafter, the present invention will be explained in detail by the following examples. However, the following examples only illustrate the present invention, and the content of the present invention is not limited by the following examples.

Example

Manufacturing example. Production of oxygen nanobubble water

Oxygen nanobubble water with an average size of 100 nm or less was produced using purified water in an oxygen nanobubble generator. The nanobubble generator used was a conventional device using a bubble encapsulation method.

Experiment example. Efficacy evaluation based on oxygen nanobubble water and peptide complex

Ingredients (% by weight) Example 1 Comparative Example 1 Oxygen Nanobubble Water
(Oxygen 30ppm or more) 94 - Purified water - 94 peptide complex 0.05 0.05 Caffeic acid 0.05 0.05 20 additional ingredients 5.9 5.9

As shown in Table 1, cosmetic compositions were prepared containing different components of Examples and Comparative Examples. Specifically, oxygen nanobubble water was prepared according to the preparation example, and acetylhexapeptide-8 was used as the peptide complex.

In addition, 20 additional ingredients include propylene glycol dicaprylate/dicaprate at 1.15% by weight, glycerin, dippylene glycol, and 1,2-hexanediol at 1.05% by weight each, and pot Marigold flower extract, Iceland moss extract, damask rose flower extract, glyceryl acrylate/acrylic acid copolymer, ammonium acryloyl dimethyl taurate/V picopolymer, acrylate/C10-30 alkyl acrylate crosspolymer, 0.1% by weight each of cetearyl glucoside, sorbitan olivate, cetearyl alcohol, fragrance, tromethamine, butylene glycol, sodium hyaluronate crosspolymer, benzyl glycol, ethylhexyl glycerin, and glyceryl glucoside. included.

Next, the skin permeability evaluation and sensory evaluation of the cosmetic composition prepared according to Table 1 were measured and shown in Tables 2 and 3 below.

1. Skin permeability evaluation

를 유지하며, 시간대별로 용출액 모두를 채취한 후 농축하여 HPLC를 통하여 투과된 카페익산의 함량을 분석하여 하기 표 2에 나타내었다.Skin permeability was measured using the Franz cell test. Specifically, the cosmetic composition according to Table 1 above was applied to one side of a skin substitute (membrane used in the experiment: Start-M membrane manufactured by Merck Millipore), and a solution (eluate, media) composed of components of body fluid was applied to the other side. The permeability (skin) of caffeic acid was measured by contacting with . The temperature of the solution is 37 degrees Celsius, which is the same as the temperature inside the skin.

was maintained, all of the eluates were collected for each time period, concentrated, and the content of permeated caffeic acid was analyzed through HPLC, which is shown in Table 2 below.

time (hr) Example 1 (mg) Comparative Example 1 (mg) 2 hours 0 0 4 hours 1.82 1.07 8 hours 3.02 1.21 12 hours 8.91 4.25

As shown in Table 2, in the case of Example 1 containing oxygen nanobubble water, it was confirmed that the skin permeability of caffeic acid over time was 1.7 to 2.5 times higher than that of Comparative Example 1 containing purified water.

Therefore, it was found that the inclusion of oxygen nanobubble water had an effect on increasing the permeability of caffeic acid.

2. Sensory evaluation

Sensory evaluation was conducted on 20 men and women (age distribution 19-35 years old), and the cosmetic compositions prepared according to Table 1 above were applied to the skin and examined for initial moisture, moisturizing sensation, and overall feeling of use. Specifically, the initial moisture sensation was investigated based on the moistness of the formulation upon application, and the moisturizing sensation was investigated based on the moisturizing sensation felt after application. Very good: 5 points, good: 4 points, average: 3 points, bad: 2 points, very bad: 1. It was evaluated based on the evaluation criteria of points.

division Example 1 Comparative Example 1 Initial moisture 4.0 3.8 Moisturizing 4.2 3.0 Overall feeling of use 4.1 3.2 medium 4.1 3.3

As shown in Table 3 above, in the case of Example 1 including oxygen nanobubble water, the initial moisture feeling, moisturizing feeling, and overall feeling of use were all excellent at 4.0 points or higher, and the average value of the sensory evaluation results was confirmed to be significantly superior at 4.1 points or higher.

Next, Comparative Example 1 contained purified water, and it was confirmed that it had a significantly lower feeling of use compared to Example 1, with an average value of 3.3 points.

Accordingly, when oxygen nanobubble water and peptide complex are included as in the present invention, skin permeability or skin absorption rate can be improved to improve skin permeability of skin effective substances or physiologically active substances, and by supplying oxygen to the skin, the skin permeability or skin absorption rate can be improved. By activating metabolism, it can provide excellent hydration, moisturizing effect, and improved feeling of use.

As the specific parts of the present invention have been described in detail above, it is clear to those skilled in the art that these specific techniques are merely preferred implementation examples and do not limit the scope of the present invention. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (6)

A cosmetic composition containing oxygen nanobubble water and a peptide complex. According to paragraph 1,
A cosmetic composition characterized in that the oxygen nanobubble water contains more than 30 ppm of oxygen. The cosmetic composition according to claim 1, wherein the average size of the nanoparticles of the oxygen nanobubble water is 150 nm or less. According to paragraph 1,
A cosmetic composition characterized in that the peptide complex includes acetylhexapeptide. According to paragraph 1,
A cosmetic composition in which the peptide complex is contained in an amount of 0.001 to 0.5% by weight based on the total weight of the cosmetic composition. According to paragraph 1,
The cosmetic composition further includes caffeic acid.