KR102516995B1 - 조정가능한 성장 인자 레벨을 가진 활성화된 혈소판 조성 - Google Patents

조정가능한 성장 인자 레벨을 가진 활성화된 혈소판 조성 Download PDF

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KR102516995B1
KR102516995B1 KR1020187032082A KR20187032082A KR102516995B1 KR 102516995 B1 KR102516995 B1 KR 102516995B1 KR 1020187032082 A KR1020187032082 A KR 1020187032082A KR 20187032082 A KR20187032082 A KR 20187032082A KR 102516995 B1 KR102516995 B1 KR 102516995B1
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growth factor
sample
platelet
electrical
pulse
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KR1020187032082A
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Korean (ko)
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KR20190005856A (ko
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바실 보그단 네쿨리스
후안 호세 베세라
크리스틴 안젤라 모톤
앤드류 솔리즈 토레스
안토니오 카이아파
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제네럴 일렉트릭 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
    • G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
    • G05B13/04—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
    • G05B13/042—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators in which a parameter or coefficient is automatically adjusted to optimise the performance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Electromagnetism (AREA)
  • Immunology (AREA)
  • Computer Hardware Design (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Medical Informatics (AREA)
  • Software Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020187032082A 2016-04-05 2016-04-05 조정가능한 성장 인자 레벨을 가진 활성화된 혈소판 조성 KR102516995B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/025990 WO2017176253A1 (en) 2016-04-05 2016-04-05 Activated platelet composition with tunable growth factor level

Publications (2)

Publication Number Publication Date
KR20190005856A KR20190005856A (ko) 2019-01-16
KR102516995B1 true KR102516995B1 (ko) 2023-03-31

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KR1020187032082A KR102516995B1 (ko) 2016-04-05 2016-04-05 조정가능한 성장 인자 레벨을 가진 활성화된 혈소판 조성

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JP (1) JP6840770B2 (zh)
KR (1) KR102516995B1 (zh)
CN (1) CN109072166A (zh)
CA (1) CA3018505A1 (zh)
WO (1) WO2017176253A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7025070B1 (ja) 2021-05-14 2022-02-24 セルソース株式会社 血液由来成長因子含有組成物及びその調製方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140363412A1 (en) * 2013-06-06 2014-12-11 General Electric Company Platelet activation using long electric field pulses
WO2015108778A1 (en) * 2014-01-17 2015-07-23 General Electric Company Platelet activation and growth factor release using electric pulses

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
CN1195997A (zh) * 1995-03-10 1998-10-14 恩特雷麦德有限公司 流式电穿孔室和方法
TW200505394A (en) * 2003-06-06 2005-02-16 Asahi Medical Co Material promoting wound healing
TWI354024B (en) * 2008-01-23 2011-12-11 Bio Stem Technology Co Compositions of growth factors for enhancing the w
CN104981477A (zh) * 2012-08-22 2015-10-14 生物医学美国有限公司 用于通过磁感测执行血液凝血弹性描记测定的设备和方法
CN102988964A (zh) * 2012-11-02 2013-03-27 广州军区广州总医院 一种复合生长因子及其制备方法与应用
US9708597B2 (en) * 2014-01-17 2017-07-18 General Electric Company Electric pulse generation systems using capacitive coupling

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140363412A1 (en) * 2013-06-06 2014-12-11 General Electric Company Platelet activation using long electric field pulses
WO2015108778A1 (en) * 2014-01-17 2015-07-23 General Electric Company Platelet activation and growth factor release using electric pulses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Jue Zhang et. al.. Nanosecond pulse electric ?eld (nanopulse): A novel non-ligand agonist for platelet activation. Archives of Biochemistry and Biophysics. (2008), Vol.471, pp.240-248. 1부.*

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Publication number Publication date
CA3018505A1 (en) 2017-10-12
JP6840770B2 (ja) 2021-03-10
CN109072166A (zh) 2018-12-21
KR20190005856A (ko) 2019-01-16
WO2017176253A1 (en) 2017-10-12
JP2019513360A (ja) 2019-05-30

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