KR102511855B1 - 일주기 리듬 수면 장애를 치료하는 방법 - Google Patents

일주기 리듬 수면 장애를 치료하는 방법 Download PDF

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KR102511855B1
KR102511855B1 KR1020187035708A KR20187035708A KR102511855B1 KR 102511855 B1 KR102511855 B1 KR 102511855B1 KR 1020187035708 A KR1020187035708 A KR 1020187035708A KR 20187035708 A KR20187035708 A KR 20187035708A KR 102511855 B1 KR102511855 B1 KR 102511855B1
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pharmaceutical composition
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KR20190013820A (ko
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카스텐 티. 뷰크만
마가렛 몰린
앤드류 사틀린
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에자이 알앤드디 매니지먼트 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020187035708A 2016-05-12 2017-05-11 일주기 리듬 수면 장애를 치료하는 방법 Active KR102511855B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237009013A KR20230043227A (ko) 2016-05-12 2017-05-11 일주기 리듬 수면 장애를 치료하는 방법

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662335599P 2016-05-12 2016-05-12
US201662335611P 2016-05-12 2016-05-12
US62/335,611 2016-05-12
US62/335,599 2016-05-12
US201662413976P 2016-10-27 2016-10-27
US62/413,976 2016-10-27
US201662414606P 2016-10-28 2016-10-28
US201662414599P 2016-10-28 2016-10-28
US62/414,606 2016-10-28
US62/414,599 2016-10-28
PCT/US2017/032228 WO2017197160A1 (en) 2016-05-12 2017-05-11 Methods of treating circadian rhythm sleep disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237009013A Division KR20230043227A (ko) 2016-05-12 2017-05-11 일주기 리듬 수면 장애를 치료하는 방법

Publications (2)

Publication Number Publication Date
KR20190013820A KR20190013820A (ko) 2019-02-11
KR102511855B1 true KR102511855B1 (ko) 2023-03-20

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Application Number Title Priority Date Filing Date
KR1020187035708A Active KR102511855B1 (ko) 2016-05-12 2017-05-11 일주기 리듬 수면 장애를 치료하는 방법
KR1020237009013A Ceased KR20230043227A (ko) 2016-05-12 2017-05-11 일주기 리듬 수면 장애를 치료하는 방법

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KR1020237009013A Ceased KR20230043227A (ko) 2016-05-12 2017-05-11 일주기 리듬 수면 장애를 치료하는 방법

Country Status (16)

Country Link
US (2) US11096941B2 (https=)
EP (2) EP4056180A1 (https=)
JP (2) JP6888026B2 (https=)
KR (2) KR102511855B1 (https=)
CN (1) CN109640998A (https=)
AU (3) AU2017264871B2 (https=)
CA (1) CA3022068A1 (https=)
ES (1) ES2904625T3 (https=)
IL (2) IL291791B2 (https=)
MX (1) MX379318B (https=)
MY (1) MY199382A (https=)
RU (1) RU2763493C2 (https=)
SG (1) SG11201809527UA (https=)
TW (1) TWI795359B (https=)
WO (1) WO2017197160A1 (https=)
ZA (1) ZA201807903B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11096941B2 (en) * 2016-05-12 2021-08-24 Eisai R&D Management Co.. Ltd. Methods of treating circadian rhythm sleep disorders
BR112021026291A2 (pt) * 2019-06-26 2022-03-03 Eisai R&D Man Co Ltd Lemborexant para tratar problemas de sono
JP2022538170A (ja) * 2019-06-26 2022-08-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 睡眠問題の治療のためのレンボレキサント
WO2020263253A1 (en) * 2019-06-26 2020-12-30 Moline Margaret Lemborexant for treating sleep issues
JP7573015B2 (ja) * 2019-09-13 2024-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 不眠症治療用医薬組成物
JP2023506025A (ja) * 2019-12-11 2023-02-14 テバ チェコ インダストリーズ エス．アール．オー． レンボレキサントの固体形態
MX2022008260A (es) * 2020-01-16 2022-08-04 Eisai R&D Man Co Ltd Sustancia farmacologica de lemborexant y composicion medicinal que la comprende.
CN111450076A (zh) * 2020-05-25 2020-07-28 安徽省逸欣铭医药科技有限公司 一种Lemborexant软胶囊组合物及其制备方法
CN114159568B (zh) * 2020-09-11 2025-08-01 北京原基华毅生物科技有限公司 Sik抑制剂在制备用于预防和/或治疗睡眠障碍的药物中的应用
WO2023007320A1 (en) * 2021-07-26 2023-02-02 Eisai R&D Mangement Co., Ltd. Lemborexant for use in methods of treating irregular sleep-wake rhythm disorder and circadian rhythm sleep disorders associated with neurodegenerative diseases
CN116421605B (zh) * 2022-01-04 2024-08-02 中国科学院脑科学与智能技术卓越创新中心 Isx-9在治疗衰老相关的昼夜节律幅度下降和睡眠障碍方面的应用
WO2024064897A1 (en) 2022-09-23 2024-03-28 Eisai R&D Management Co., Ltd. Methods of reducing neurodegeneration associated with neurodegenerative diseases
CN121646412A (zh) 2023-08-08 2026-03-10 株式会社明治 昼夜节律的调整

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016063995A1 (en) 2014-10-23 2016-04-28 Eisai R&D Management Co., Ltd. Compositions and methods for treating insomnia

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Publication number Priority date Publication date Assignee Title
MXPA06009377A (es) * 2004-02-20 2007-03-07 Lifescape Biosciences Inc Composiciones y metodos para regulacion del sueno.
ATE458740T1 (de) * 2006-08-28 2010-03-15 Actelion Pharmaceuticals Ltd 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen- derivate als orexinrezeptor-antagonisten
AU2011304285B2 (en) 2010-09-22 2015-01-29 Eisai R&D Management Co., Ltd. Cyclopropane compound
CA2863413A1 (en) * 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
US11096941B2 (en) * 2016-05-12 2021-08-24 Eisai R&D Management Co.. Ltd. Methods of treating circadian rhythm sleep disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016063995A1 (en) 2014-10-23 2016-04-28 Eisai R&D Management Co., Ltd. Compositions and methods for treating insomnia

Also Published As

Publication number Publication date
RU2018143809A3 (https=) 2020-09-17
CA3022068A1 (en) 2017-11-16
BR112018073037A2 (pt) 2019-02-26
JP6888026B2 (ja) 2021-06-16
AU2025205336A1 (en) 2025-07-31
MX2018013663A (es) 2019-07-18
JP2019518732A (ja) 2019-07-04
JP2021120410A (ja) 2021-08-19
RU2018143809A (ru) 2020-06-15
MX379318B (es) 2025-03-10
US20200179382A1 (en) 2020-06-11
US11096941B2 (en) 2021-08-24
WO2017197160A1 (en) 2017-11-16
AU2023203418A1 (en) 2023-06-29
RU2763493C2 (ru) 2021-12-29
NZ748555A (en) 2025-06-27
IL291791B2 (en) 2025-09-01
IL262803B (en) 2022-05-01
SG11201809527UA (en) 2018-11-29
KR20190013820A (ko) 2019-02-11
CN109640998A (zh) 2019-04-16
EP3454859A1 (en) 2019-03-20
IL291791A (en) 2022-06-01
ZA201807903B (en) 2021-04-28
AU2017264871B2 (en) 2023-03-16
AU2017264871A1 (en) 2018-11-15
IL291791B1 (en) 2025-05-01
US20210353625A1 (en) 2021-11-18
IL262803A (en) 2018-12-31
KR20230043227A (ko) 2023-03-30
TW201740952A (zh) 2017-12-01
EP4056180A1 (en) 2022-09-14
MY199382A (en) 2023-10-25
TWI795359B (zh) 2023-03-11
JP7150096B2 (ja) 2022-10-07
EP3454859B1 (en) 2021-12-01
ES2904625T3 (es) 2022-04-05

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