KR102511249B1 - 신규한 안정한 항체-약물 복합체, 이의 제조방법 및 이의 용도 - Google Patents

신규한 안정한 항체-약물 복합체, 이의 제조방법 및 이의 용도 Download PDF

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KR102511249B1
KR102511249B1 KR1020167033391A KR20167033391A KR102511249B1 KR 102511249 B1 KR102511249 B1 KR 102511249B1 KR 1020167033391 A KR1020167033391 A KR 1020167033391A KR 20167033391 A KR20167033391 A KR 20167033391A KR 102511249 B1 KR102511249 B1 KR 102511249B1
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KR20170020328A (ko
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강 친
진도 위안
루 장
추빙 탄
릴리 스
카오 엘브이
레이레이 첸
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진콴텀 헬스케어 (쑤저우) 씨오., 엘티디.
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    • A—HUMAN NECESSITIES
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020167033391A 2014-04-29 2015-04-29 신규한 안정한 항체-약물 복합체, 이의 제조방법 및 이의 용도 Active KR102511249B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410174890.8 2014-04-29
CN201410174890 2014-04-29
PCT/CN2015/077887 WO2015165413A1 (zh) 2014-04-29 2015-04-29 一种新型的稳定型抗体药物耦联物及其制备方法和用途

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KR20170020328A KR20170020328A (ko) 2017-02-22
KR102511249B1 true KR102511249B1 (ko) 2023-03-20

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US (5) US11040084B2 (https=)
EP (2) EP3138568B1 (https=)
JP (2) JP6666264B2 (https=)
KR (1) KR102511249B1 (https=)
CN (2) CN106856656B (https=)
AU (2) AU2015252518B2 (https=)
ES (1) ES2736505T3 (https=)
WO (1) WO2015165413A1 (https=)

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CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
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KR20230147105A (ko) 2021-01-28 2023-10-20 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. 리가제 융합 단백질 및 그 응용
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CN117177775A (zh) * 2021-04-14 2023-12-05 启德医药科技（苏州）有限公司 连接子、缀合物及其应用
TW202308700A (zh) * 2021-04-29 2023-03-01 大陸商上海匯連生物醫藥有限公司 抗體偶聯藥物的製備方法及應用
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