KR102507571B1 - Packaging structure of patch - Google Patents

Abstract

[Problem] It has a wide seal suitable temperature range while suppressing the deterioration of the adhesive performance of the patch, suppression of volatilization of the percutaneous absorption component, and openability of the packaging structure, and also adheres even when foreign matter adheres to the heat seal surface. Provided is a packaging structure of a patch that is less likely to cause defects and has excellent sealability against impurities.
[Solution] In the packaging structure for wrapping the patch with a packaging material, the innermost layer in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin-based resin, and an annular ring is formed on the outside of the heat-sealable resin layer. By providing a resin layer containing a polyolefin-based resin, and directly laminating a heat-sealable resin layer and a resin layer containing a cyclic polyolefin-based resin, the packaging structure of the patch can suitably suppress the volatilization of the active ingredient. , It is possible to realize a wide sealability temperature range and appropriate impurity sealability.

Description

Packaging structure of patch

The present invention relates to a packaging structure for packaging a patch with a packaging material.

BACKGROUND ART Patches applied to the skin surface are widely used for the purpose of administering transdermally absorbable components into the body or protecting wounds. Such a patch is usually packaged with a packaging material to prevent deterioration of sticking performance due to oxygen or moisture in the air and volatilization of transdermally absorbable ingredients such as drugs.

In the packaging structure of the patch, a packaging structure using polyacrylonitrile resin as the innermost layer of the packaging material for packaging the patch is widely used because the adsorption of the percutaneous absorption component is low and the openability of the packaging structure is easy to be secured. There is (see, for example, Patent Documents 1 to 2).

International Publication No. 2005/072675 Japanese Patent Publication No. 2009-160389

However, in the packaging structure using polyacrylonitrile resin as described above, the temperature range suitable for sealing when forming the packaging structure by heat sealing is narrow, and it is difficult to secure the seal strength depending on the conditions of the bag. there was a case In addition, in the packaging structure, adhesion is difficult to obtain when foreign matter adheres to the heat seal surface, such as inflow of liquid or adhesion of powder during heat sealing. there have been instances where

The problem to be solved by the present invention is to suppress the deterioration of the adhesive performance of the patch, the suppression of volatilization of the transdermally absorbent component, and the openability of the packaging structure, while having a wide sealability temperature range, and the removal of foreign substances on the heat seal surface. It is an object of the present invention to provide a packaging structure for a patch that is less likely to cause poor adhesion even when adhesion occurs and is excellent in sealing properties of suitable impurities.

In the present invention, in the packaging structure for packaging the patch with a packaging material, the layer serving as the innermost surface in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin-based resin, and on the outside of the heat-sealable resin layer The said subject was solved by the packaging structure of the patch in which the resin layer containing cyclic polyolefin type resin was provided, and the heat-sealable resin layer and the resin layer containing cyclic polyolefin type resin were laminated|stacked directly.

That is, the present invention is a packaging structure for packaging an adhesive agent with a packaging material, wherein the layer serving as the innermost surface in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin-based resin, and the outer side of the heat-sealable resin layer It is to provide a packaging structure for a patch in which a resin layer containing a cyclic polyolefin resin is provided, and the heat-sealable resin layer and the resin layer containing a cyclic polyolefin resin are directly laminated.

In the packaging structure of the patch of the present invention, the heat seal layer in contact with the patch when packaging the patch is a resin layer containing an olefin resin, and a resin layer containing a cyclic polyolefin resin in the resin layer By using the direct laminated packaging structure, the seal is suitable for a wide temperature range while having the effect of properly suppressing the deterioration of the adhesive performance of the patch and the volatilization of the percutaneous absorption component, and the suitable openability due to tearing. Appropriateness can be secured, and even when foreign matter such as liquid inflow or adhesion of powder adheres during heat sealing, it is possible to realize suitable impurity sealing performance that is difficult to cause adhesion failure.

In addition, according to the packaging structure of the present invention having the above configuration, it has excellent compatibility with automatic packaging machines, and even when foreign substances such as liquid inflow or powder adhesion are attached during heat sealing, adhesion failure is difficult to occur. can In addition, it is possible to express the heat seal strength required for integrated packaging in which several patches are overlapped and packaged. The generation of pinholes and darts (leakage/sealability defects) at the corners of the packaging bag, which is caused by the difference in level due to the thickness (height) of the patch stacked on several sheets, can also be suppressed. In addition, since the inner surface can be heat-sealed with a polyethylene-based resin, heat-sealed can also be applied to a polyethylene-based chuck used when opening and closing several times after unsealing is required, facilitating response.

The packaging structure of the present invention is a packaging structure in which a patch is packaged with a packaging material, and the layer serving as the innermost surface in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin-based resin, and on the outside of the heat-sealable resin layer A packaging structure in which a resin layer containing a cyclic polyolefin resin is provided, and a heat-sealing resin layer and a resin layer containing a cyclic polyolefin resin are directly laminated.

[Packaging material]

In the packaging material used for the packaging structure of the present invention, the surface layer serving as the innermost surface in the packaging structure is a heat-sealable resin layer containing an olefin-based resin (hereinafter referred to as a heat-seal layer (A)), and the heat-seal layer (A) ) has a structure in which a resin layer containing a cyclic polyolefin-based resin (hereinafter referred to as a cyclic polyolefin resin layer (B)) is directly laminated.

(Heat seal layer (A))

As the olefin-based resin used for the heat seal layer (A), polyethylene-based resins, polypropylene-based resins, and copolymers thereof can be used. As the polyethylene-based resin, the polyethylene number of ultra-low density polyethylene (VLDPE), linear low-density polyethylene (LLDPE), linear medium-density polyethylene (LMDPE), low-density polyethylene (LDPE), medium-density polyethylene (MDPE), and high-density polyethylene (HDPE) Gina, ethylene-vinyl acetate copolymer (EVA), ethylene-methyl methacrylate copolymer (EMMA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate (EMA) copolymer, ethylene-ethyl acrylate ethylenic copolymers such as late maleic anhydride copolymer (E-EA-MAH), ethylene-acrylic acid copolymer (EAA), and ethylene-methacrylic acid copolymer (EMAA); Moreover, the ionomer of an ethylene-acrylic acid copolymer, the ionomer of an ethylene-methacrylic acid copolymer, etc. are mentioned, You may use individually or may mix and use 2 or more types. Among them, suppression of volatilization of transdermal absorption components and deterioration of the adhesive performance of patches (hereinafter sometimes referred to as volatilization of active ingredients), heat sealability such as wide heat seal suitability temperature range and suitable adhesiveness are suitable. Since it is easy to realize, LLDPE can be preferably used.

The LDPE may be branched low-density polyethylene obtained by a high-pressure radical polymerization method, and is preferably a branched low-density polyethylene obtained by homopolymerization of ethylene by a high-pressure radical polymerization method.

As LLDPE and LMDPE, α-olefins such as butene-1, hexene-1, octene-1, 4-methylpentene, etc. is copolymerized. The comonomer content is preferably in the range of 0.5 to 20 mol%, and more preferably in the range of 1 to 18 mol%.

Examples of the single site catalyst include various single site catalysts such as metallocene catalyst systems such as a combination of a metallocene compound of a transition metal of Group IV or V of the periodic table, an organoaluminum compound and/or an ionic compound. In addition, since the single-site catalyst has a uniform active point, compared to a multi-site catalyst having a non-uniform active point, the obtained resin has a sharper molecular weight distribution, so when formed on a film, there is little precipitation of low-molecular-weight components, and there is little precipitation between the resin layers. This is preferable because a resin having excellent physical properties and stability in adhesive strength can be obtained.

It is preferable that it is 2-20g/10min, and, as for MFR (190 degreeC, 21.18N) of the said polyethylene-type resin, it is more preferable that it is 3-10g/10min. When the MFR is within this range, the extrusion moldability of the film is improved. The density of LLDPE is preferably 0.905 g/cm 3 to 0.925 g/cm 3 from the standpoint of packaging suitability, impurity sealing property, and pinhole resistance, and particularly preferably 0.915 g/cm 3 to 0.925 g/cm 3 because it is easy to suppress volatilization of the active ingredient. is particularly preferred.

Examples of the polypropylene resin include propylene homopolymers, propylene/α-olefin random copolymers, propylene-ethylene copolymers, propylene-butene-1 copolymers, propylene-ethylene-butene-1 copolymers, and metallo strong catalyst-based polypropylene; and the like. These may be used independently, respectively, and may be used together. A propylene/α-olefin random copolymer is preferred, and a propylene/α-olefin random copolymer polymerized using a metallocene catalyst is particularly preferred. When these polypropylene-based resins are used as the intermediate layer (B), the heat resistance of the film is improved and the softening temperature can be increased. Therefore, boiling or hot filling at 100 ° C. or lower, steam such as retort sterilization at 100 ° C. or higher · It can be suitably used as a laminated film for packaging materials having excellent high-pressure heat sterilization properties.

Further, these polypropylene resins preferably have an MFR (230°C) of 0.5 to 30.0 g/10 min, and a melting point of 110 to 165°C, more preferably, an MFR (230°C) of 2.0 to 15.0 g/10 min. 10 minutes, and the melting point is 115 to 162 ° C. When the MFR and the melting point are within these ranges, the film formability of the film is improved.

Since the heat seal layer (A) is easy to secure a wide heat seal suitability temperature range and easy to realize suitable adhesion, it is preferable to have an olefin resin as a main component, and the resin component constituting the heat seal layer (A) It is preferable that 80 mass % or more in it is olefin type resin other than the cyclic olefin type resin as illustrated above, it is more preferable that it is 90 mass % or more, and it is especially preferable that it is 100 mass %. In addition, when 80% by mass of the olefinic resin contained in the heat seal layer (A) is an olefinic resin having a density of 0.9 g/cm 3 or more, it is preferable because adhesion is particularly easy to obtain, and more preferably 90% by mass or more. In particular, it is preferable that 80 mass % of the olefin resin contained in the heat seal layer (A) is a linear low density polyethylene resin, and it is more preferable that it is 90 mass % or more.

It is also preferable to contain a cyclic polyolefin resin in the heat seal layer (A) to suppress volatilization of the active ingredient, but it is easy to secure heat seal properties such as a wide heat seal suitability temperature range and suitable adhesion, so the heat seal layer (A) The content of the cyclic polyolefin-based resin in ) is preferably 10% by mass or less, more preferably 5% by mass or less, and particularly preferably not substantially contained.

The thickness of the heat seal layer (A) may be appropriately adjusted according to the mode of use, but it is preferable to be 2 to 8 μm because it is easy to ensure suitable heat seal properties while appropriately suppressing volatilization of the active ingredient. , more preferably 3 to 6 μm.

(Cyclic polyolefin resin layer (B))

Examples of the cyclic polyolefin-based resin used for the cyclic polyolefin resin layer (B) include norbornene-based polymers, vinyl alicyclic hydrocarbon polymers, and cyclic conjugated diene polymers. Among these, a norbornene-type polymer is preferable. Further, as the norbornene-based polymer, a ring-opened polymer of norbornene-based monomers (hereinafter referred to as “COP”), a norbornene-based copolymer copolymerized with a norbornene-based monomer and an olefin such as ethylene (hereinafter referred to as “COC”) ) and the like. In addition, hydrogenated products of COP and COC are particularly preferred. Moreover, as for the weight average molecular weight of cyclic olefin resin, 5,000-500,000 are preferable, More preferably, they are 7,000-300,000.

The norbornene-based polymer and the norbornene-based monomer as a raw material are alicyclic monomers having a norbornene ring. As such a norbornene monomer, for example, norbornene, tetracyclododecene, ethylidenenorbornene, vinylnorbornene, ethylidenetetracyclododecene, dicyclopentadiene, dimethanotetrahydroflu orene, phenylnorbornene, methoxycarbonylnorbornene, methoxycarbonyltetracyclododecene, and the like. These norbornene-type monomers may be used independently or may use 2 or more types together.

The norbornene-based copolymer is obtained by copolymerization of an olefin copolymerizable with the norbornene-based monomer, and examples of such an olefin include olefins having 2 to 20 carbon atoms such as ethylene, propylene, and 1-butene. ; cycloolefins such as cyclobutene, cyclopentene, and cyclohexene; and non-conjugated dienes such as 1,4-hexadiene. These olefins may be used individually, respectively, and may use two or more types together.

As said cyclic polyolefin resin, as a commercial item, as a ring-opening polymer (COP) of a norbornene-type monomer, "ZEONOR" by Nippon Zeon Co., Ltd. etc. is mentioned, for example, a norbornene-type copolymer As (COC), "Aperu" by Mitsui Chemicals Co., Ltd., "TOPAS" by Polyplastics, etc. are mentioned, for example.

In the present invention, by using a packaging material having a configuration in which a heat seal layer (A) and a cyclic polyolefin resin layer (B) containing such a cyclic polyolefin resin are directly laminated, while favorably suppressing volatilization of the active ingredient, etc., the packaging material of can realize good tearability.

Since the cyclic polyolefin resin layer (B) easily suppresses volatilization of the active ingredient and the like and easily obtains suitable openability due to tearing of the packaging material, it is preferable to use a cyclic polyolefin resin as a main component, and It is preferable that 60 mass % or more of the resin component which comprises a polyolefin resin layer (B) is cyclic polyolefin resin, it is more preferable that it is 80 mass % or more, and it is especially preferable that it is 90 mass % or more.

In addition, since it is easy to achieve a particularly suitable effect of suppressing volatilization of active ingredients and openability, 40% by mass or more of the resin component contained in the cyclic polyolefin resin layer (B) has a glass transition point (Tg) of 100 ° C. It is preferable to use a cyclic polyolefin resin having a low Tg of less than or equal to, more preferably 50% by mass or more, and particularly preferably 50 to 80% by mass. In addition, the glass transition point, melting point, etc. as used in the present invention are values measured by differential scanning calorimetry (DSC). The glass transition temperature of the low-Tg cyclic polyolefin resin is more preferably 90°C or less, and particularly preferably 60 to 80°C.

It is also preferable to use a high Tg cyclic polyolefin resin having a glass transition point of more than 100°C in combination with the low Tg cyclic polyolefin resin having a glass transition point of 100°C or less. By using a low Tg cyclic polyolefin resin and a high Tg cyclic polyolefin resin together, it becomes easy to improve the tensile strength, heat resistance, etc. of the packaging material obtained. The content of the high Tg cyclic polyolefin resin makes it easy to obtain suitable rigidity and impurity sealability when improving the tensile strength and heat resistance of the resulting packaging material, and it is easy to suppress pinholes, so the cyclic polyolefin resin layer (B) It is preferable to set it as 60 mass % or less of the resin component contained in, It is more preferable to set it as 50 mass % or less, and it is especially preferable to set it as 20-50 mass %. The glass transition temperature of the high-Tg cyclic polyolefin resin is preferably 120°C or higher, more preferably 130°C or higher, and particularly preferably 135 to 150°C.

Further, in the cyclic polyolefin resin layer (B), it is also possible to use a polyolefin resin such as a polypropylene resin or a polyethylene resin that does not contain a cyclic structure in combination to improve heat resistance and breakage resistance. Valid. In the case of using a polyolefin-based resin that does not contain these cyclic structures, it is preferably 20% by mass or less, more preferably 10% by mass or less, in the resin component contained in the cyclic polyolefin-based resin layer (B). , It is more preferable to set it as 5 mass % or less. Moreover, as for the lower limit of content of polyolefin resin which does not contain a cyclic structure, it is preferable that it is 1 mass % or more, and it is more preferable that it is 2 mass % or more.

The thickness of the cyclic polyolefin resin layer (B) may be appropriately adjusted according to the usage mode, but while appropriately suppressing volatilization of the active ingredient, it is easy to secure suitable impurity sealing properties, and it is easy to suppress pinholes during packaging. It is preferably 3 to 12 μm, more preferably 4 to 10 μm, and particularly preferably 5 to 8 μm.

(layer composition)

The packaging material used in the present invention is a packaging material composed of a laminated film in which at least the heat seal layer (A) and the cyclic polyolefin resin layer (B) are laminated. The layer configuration of the laminated film used as the packaging material may be a layer configuration of (A)/(B) consisting of the heat seal layer (A) and the cyclic polyolefin resin layer (B), but on the outer layer of the layer (B), , A resin layer containing an olefin resin (hereinafter referred to as a resin layer (C)) or a cyclic polyolefin resin layer containing a cyclic polyolefin resin (hereinafter referred to as a resin layer (D)) may be laminated. .

Preferred structural examples of the structure in which these other layers are laminated include, for example, a three-layer structure such as (A)/(B)/(C), (A)/(B)/(D), (A)/( B) / (C) / (D) 4-layer configuration and the like can be exemplified. Among them, the structure of (A) / (B) / (C) / (D) is preferable because it is easy to adjust the performance such as suppression of volatilization of the active ingredient, openability, heat sealability, etc. particularly suitably. Further, the layer (A) and the layer (C), and the layer (B) and the layer (D) may be layers of the same composition or may be layers of different compositions.

In the packaging material used in the present invention, by providing the resin layer (C), flexibility, cold resistance, impact resistance, pinhole resistance, impurity sealability, curl resistance and the like of the packaging material can be suitably adjusted. For this reason, it is preferable to appropriately select the olefinic resin used for the resin layer (C) according to the use or use mode.

As the olefin resin used for the resin layer (C), an olefin resin similar to that of the heat seal layer (A) can be preferably used, but it is easy to obtain interlayer adhesiveness with other layers, and also from the viewpoint of industrial availability In, it is preferable to use a polyethylene-based resin or a polypropylene-based resin, and a polyethylene-based resin is particularly preferable.

As the polyethylene-based resin, since it is easy to obtain cold resistance, pinhole resistance, interlayer adhesion to multilayers, etc., a density of 0.915 to 0.950 g/cm 3 is preferable, more preferably a density of 0.920 to 0.945 g/cm 3 is preferable. can be used In addition, the melting point is generally preferably in the range of 70 to 130°C, more preferably 80 to 125°C. When the melting point is within this range, processing stability and co-extrusion processability with the cyclic polyolefin-based resin (a) are improved. Moreover, it is preferable that it is 2-20g/10min, and, as for MFR (190 degreeC, 21.18N) of the said polyethylene-type resin, it is more preferable that it is 3-10g/10min. When the MFR is within this range, the extrusion moldability of the film is improved.

Among the polyethylene-based resins, LLDPE and LMDPE can be particularly preferably used because suitable opening properties due to tearing and pinhole resistance of packaging materials are easy to be obtained.

Further, the polypropylene resin preferably has an MFR (230°C) of 0.5 to 30.0 g/10 min and a melting point of 110 to 165°C, more preferably has an MFR (230°C) of 2.0 to 15.0 g/10 min. min, and the melting point is 115 to 162 ° C. When the MFR and the melting point are within these ranges, the film formability of the film is improved.

It is preferable that 80 mass % or more of the resin component which comprises a resin layer (C) is olefin type resin, and, as for content of the olefin type resin in a resin layer (C), it is more preferable that it is 90 mass % or more.

In addition, you may mix other resins other than olefin resin within the range which does not impair the effect of this invention. As other resins that can be mixed and used at this time, those to which the coextrusion lamination method can be applied, such as the cyclic polyolefin resin described above, are preferable.

The thickness of the resin layer (C) may be appropriately adjusted according to the usage mode, but it is preferably 10 to 30 μm, more preferably 13 to 20 μm, because it is easy to obtain suitable packaging properties and dirt sealing properties.

The packaging material used in the present invention can suitably suppress migration of adhesive components when laminating substrates as described later and printing ink or the like when a printing layer is provided by the above configuration, By providing a resin layer (D), it can suppress especially suitably. Moreover, since adjustment of curl resistance etc. also becomes easy, it is preferable.

As the cyclic polyolefin-based resin used for the resin layer (D), a cyclic polyolefin-based resin similar to that of the cyclic polyolefin-based resin layer (B) can be preferably used.

The resin layer (D) preferably has a cyclic polyolefin-based resin as a main component, preferably 80% by mass or more of the resin component constituting the resin layer (D) is a cyclic polyolefin-based resin, and more preferably 90% by mass or more. desirable.

In addition, the glass transition point of the cyclic polyolefin-based resin used in the resin layer (D) is 200 ° C. or less from the viewpoint of easy production by the co-extrusion lamination method with other resin layers and availability of industrial raw materials. it is desirable As the cyclic polyolefin-based resin having such a Tg, the content of the norbornene-based monomer is preferably in the range of 40 to 90% by mass, more preferably 50 to 90% by mass, still more preferably 60 to 85% by mass. am. When the content ratio is within this range, it is easy to improve the rigidity, easy tearing property, and lamination properties.

In addition, since migration of low-molecular-weight compounds and volatile components from the contents to the laminate layer is easily suppressed, a high-Tg cyclic polyolefin resin having a glass transition point exceeding 100°C is included in the resin layer (D) as a resin component. It is preferable to set it as 20-60 mass % in, and it is more preferable to set it as 20-50 mass %. By setting it as the said range, since it is easy to improve the tear easily and rigidity of the packaging material obtained, it is preferable. The glass transition temperature of the high-Tg cyclic polyolefin resin is preferably 120°C or higher, more preferably 130°C or higher, and particularly preferably 135 to 150°C.

On the other hand, norbornene-based copolymers with high Tg have low tensile strength and are extremely brittle and prone to tearing, so the balance between winding and winding aptitude and laminate strength during film formation and slitting In view of this, it is also preferable to blend a low-Tg cyclic polyolefin-based resin having a glass transition point of 100°C or less with a high-Tg cyclic polyolefin-based resin. In particular, it is preferable to blend a COC having a Tg of less than 100°C to develop high seal strength and improve breakage resistance. The content of the low-Tg cyclic polyolefin resin is more preferably 50% by mass or more in the resin component contained in the resin layer (D), and particularly preferably 50 to 80% by mass. Further, the glass transition temperature of the low-Tg cyclic polyolefin-based resin is more preferably 90°C or less, and particularly preferably 60 to 80°C.

In the resin layer (D), it is also effective to mix a polyolefin-based resin such as a polypropylene-based resin or a polyethylene-based resin that is compatible with COC and does not contain a cyclic structure. In the case of using a polyolefin-based resin that does not contain these cyclic structures, it is preferably 20% by mass or less, more preferably 10% by mass or less, in the resin component contained in the cyclic polyolefin-based resin layer (B). , It is more preferable to set it as 5 mass % or less. Moreover, as for the lower limit of content of polyolefin resin which does not contain a cyclic structure, it is preferable that it is 1 mass % or more, and it is more preferable that it is 2 mass % or more.

The thickness of the resin layer (D) may be appropriately adjusted depending on the mode of use, but it is preferably 1 to 10 μm, more preferably 2 to 8 μm, and preferably 2 to 8 μm, because it is easy to manufacture by the coextrusion lamination method. It is especially preferable that it is 5 micrometers.

The laminated film used for the packaging material suppresses volatilization of the active ingredient appropriately, and easily obtains suitable heat-sealability and openability, and also facilitates lamination with other substrates, so the total thickness thereof is 10 to 100 It is preferably in the range of μm, and more preferably in the range of 20 to 60 μm.

As the layer configuration of the packaging material, when the four-layer configuration of (A) / (B) / (C) / (D) is used, it is easy to obtain suitable heat-sealability and easily suppress volatilization of the active ingredient. It is preferable that the thickness ratio with respect to the total thickness of layer (A) is 10 to 25%, and it is more preferable that it is 10 to 20%. In addition, since volatilization of the active ingredient is easily suppressed and good openability is easily obtained, the thickness ratio of the layer (B) to the total thickness is preferably 15 to 30%. In addition, since good openability is easy to be obtained, it is preferable that the ratio of the thickness of the total thickness of the layer (D) and the layer (B) to the total thickness is 40% or more and 60% or less. In addition, the total thickness of the cyclic polyolefin resin layer (B) and the resin layer (D) may be appropriately adjusted according to the usage mode, but it is easy to ensure suitable openability while appropriately suppressing volatilization of the active ingredient, etc. It is preferable that it is 6-15 micrometers, and it is more preferable that it is 8-13 micrometers.

In each of the above resin layers, as necessary, components such as an antifogging agent, an antistatic agent, a heat stabilizer, a nucleating agent, an antioxidant, a lubricant, an antiblocking agent, a mold release agent, an ultraviolet absorber, and a colorant may be added without impairing the object of the present invention. range can be added. In particular, in order to impart processing suitability at the time of film formation and packaging suitability for filling machines, the friction coefficient on the film surface of the layers (A) and (D) is preferably 1.5 or less, especially 1.0 or less, so that the resin layer (A ), it is preferable to appropriately add a lubricant or an antiblocking agent.

Although it does not specifically limit as a manufacturing method of the said laminated|multilayer film, For example, each resin or resin mixture used for each layer is heat-melted with a separate extruder, and it is a method, such as a coextrusion multilayer die method and a feed block method, A co-extrusion method in which each layer is laminated in a molten state and then formed into a film by inflation or a T-die chilled roll method or the like can be preferably used. The co-extrusion method is preferable because the ratio of the thickness of each layer can be relatively freely adjusted, and a laminated film having excellent hygiene and excellent cost performance can be obtained. In addition, when a low-density polyethylene-based resin is used for the layer containing the cyclic polyolefin-based resin used in the present invention and the resin layer to be laminated, the difference between the melting point and Tg between the two is large, so that the film appearance deteriorates during co-extrusion processing. However, there are cases where it is difficult to form a uniform layer structure. In order to suppress such deterioration, a T-die chilled roll method capable of melt-extruding at a relatively high temperature is preferable.

The packaging material used in the present invention may be a packaging material made of the above-mentioned laminated film, but a packaging material made of a laminated film in which the above-mentioned laminated film is used as a sealant film and a base material is bonded to the outer layer of the sealant film layer (A) and the other side. It is desirable to be As the substrate, it is preferable to use a plastic substrate having high rigidity and high gloss, particularly a biaxially stretched resin film. In addition, in the case of applications that do not require transparency, aluminum foil may be used alone or in combination.

Examples of the stretched resin film include biaxially stretched polyester (PET), heat-resistant biaxially stretched polyester (PET), biaxially stretched polypropylene (OPP), and biaxially stretched from the viewpoint of easy tearing property and the like. Co-extruded biaxially oriented polypropylene with polyamide (PA) and ethylene-vinyl alcohol copolymer (EVOH) as the center layer, co-extruded biaxially coated with biaxially oriented ethylene-vinyl alcohol copolymer (EVOH) and polyvinylidene chloride (PVDC) Stretched polypropylene etc. are mentioned. These may be used individually or in combination.

The laminate film is a film formed by laminating the above substrate on the laminate film obtained by the above production method, and examples of the laminate method include methods such as dry lamination, wet lamination, non-solvent lamination, and extrusion lamination. .

Examples of the adhesive used in the dry lamination include polyether-polyurethane adhesives and polyester-polyurethane adhesives. Moreover, although various adhesives can also be used, it is preferable to use a pressure-sensitive adhesive. As the pressure-sensitive adhesive, for example, polyisobutylene rubber, butyl rubber, or a rubber-based adhesive in which a mixture thereof is dissolved in an organic solvent such as benzene, toluene, xylene, or hexane, or abiethylene acid rosin in these rubber-based adhesives A mixture of a tackifier such as ester, terpene/phenol copolymer, or terpene/indene copolymer, or 2-ethylhexyl acrylate/n-butyl acrylate copolymer, 2-ethylhexyl acrylate/ethyl acrylate/methaacrylate and an acrylic pressure-sensitive adhesive obtained by dissolving an acrylic copolymer having a glass transition point of -20°C or lower, such as a methyl acrylate copolymer, in an organic solvent.

In the case of laminating the base material, the outermost surface of the laminated film on which the base material is laminated is in order to improve the applicability of the above-mentioned adhesive or pressure-sensitive adhesive, or in the case of laminating with the base material after printing or the like on the outermost surface. In this case, it is preferable to perform surface treatment in order to improve adhesion to adhesives, pressure-sensitive adhesives, printing inks, and the like. Examples of such surface treatment include surface oxidation treatment such as corona treatment, plasma treatment, chromic acid treatment, flame treatment, hot air treatment, ozone/ultraviolet treatment, or surface roughening treatment such as sandblasting, but preferably is the corona treatment. If the surface on which the substrate is laminated is a layer containing a cyclic polyolefin-based resin, even if stored for a long period of time after such a treatment, the degree of treatment does not deteriorate over time, and a final product can be stably provided.

[patch]

The patch in the present invention is a dressing agent used by sticking to the skin of a human body or animal for administration of drugs or wound protection, patches such as patches, plasters, dressing materials, transdermal absorbent tape preparations, etc. am. As the form of the patch, a form in which an adhesive layer is provided on one side or both sides of the support can be preferably exemplified, and if necessary, a transdermal absorption component such as a drug is contained in the adhesive layer. In addition, a release liner may be provided on the surface of the pressure-sensitive adhesive layer. According to the packaging structure of the present invention, when such a patch is used, volatilization of the active ingredient can be appropriately suppressed.

As the support used for the patch, one that is difficult to permeate the percutaneous absorption component or the like contained in the pressure-sensitive adhesive layer can be preferably used. Examples of such a support include resin films and metal foils such as polyester, nylon, polyethylene, polypropylene, polyvinyl chloride, ethylene-ethyl acrylate copolymer, and polytetrafluoroethylene. Moreover, the film which laminated|stacked these films etc. suitably may be sufficient. The thickness of the support is preferably 10 to 500 μm, more preferably 10 to 200 μm.

The adhesive used for the pressure-sensitive adhesive layer can be used without particular limitation as long as it has adhesiveness to the skin. As such an adhesive, for example, acrylic adhesive, SIS (styrene-isoprene-styrene), SBS (styrene-butadiene-styrene), polyisoprene, rubber-based adhesive such as polybutadiene, silicone-based adhesive, vinyl ester-based adhesive, polyester system adhesive etc. can be illustrated. Among them, an acrylic adhesive can be preferably used because it is easy to make the adhesive contain a large amount of transdermally absorbable components and the like, and it is easy to obtain suitable adhesion to the skin. In addition, a rubber-based pressure-sensitive adhesive is preferable because it is easy to obtain stability of a transdermal absorption component or the like.

As the transdermally absorbable component to be contained in the adhesive layer, various physiologically active components can be used depending on the application, for example, anesthetics, sedatives, anticonvulsants, antipyretic analgesics, anti-inflammatory drugs, antispasmodics, psychoactive drugs, and skeletal muscle relaxants. , autonomic nerve drugs, antihistamines, cardiac drugs, arrhythmia drugs, diuretics, antihypertensive drugs, vasoconstrictors, vasodilators, peripheral vasodilators, arteriosclerosis drugs, circulatory drugs, respiratory stimulants, antitussive expectorants, Hormone drugs, external drugs for purulent diseases, anti-inflammatory drugs, hemostatic drugs, gout treatment drugs, diabetes drugs, anti-malignant tumor drugs, antibiotics, smoking cessation aids, and the like can be exemplified.

[Packaging structure]

The packaging structure of the present invention is a packaging structure in which a patch is wrapped in a packaging material, and the patch is packaged with the heat seal layer (A) of the packaging material as the innermost surface. As the packaging structure, a structure in which the patch is sandwiched between two film-like packaging materials and heat-sealed around the patch, and a structure in which the patch is folded so as to be sandwiched between one film-like packaging material and the periphery of the patch A heat-sealed structure, a packaging structure in which the top and bottom are sealed after sealing the end of the roll-shaped film in a cylindrical (pillow) shape by an automatic packaging machine, etc. can be illustrated.

Further, in the packaging structure of the present invention, in order to reduce initial tear strength and improve openability, arbitrary tear start portions such as V-notches, I-notches, seams, and micropores may be formed in the seal portion. In addition, a polyethylene-based chuck that can be opened and closed after unsealing may be provided in a part of the packaging structure.

The packaging structure of the present invention is suitable in a wide temperature range while having the effect of suppressing the deterioration of the sticking performance of the patch and the volatilization of the transdermally absorbent component appropriately, and the suitable openability by tearing due to the above configuration. Sealing suitability can be ensured, and even when foreign matter such as liquid inflow or powder adheres during heat sealing, it is possible to realize suitable impurity sealing performance that is difficult to cause adhesion failure, so it is suitable for packaging applications of adhesives. can be applied Further, the packaging material used in the packaging structure of the present invention has excellent suitability for automatic packaging machines and can realize suitable impurity sealing properties. In addition, while being able to develop the heat seal strength required for integrated packaging in which several patches are stacked and packaged, the occurrence of pinholes and darts (leakage/sealability defects) at the corners of the packaging structure can also be suppressed. In addition, since the heat seal layer on the innermost surface can be heat-sealed with a polyethylene-based resin, it is possible to provide a polyethylene-based chuck used when opening and closing several times after unsealing is required.

(Example)

Next, the present invention will be described in more detail by giving Examples and Comparative Examples.

(Example 1)

As resin components forming each layer of the heat seal layer (A), the cyclic olefin resin layer (B), the middle layer resin layer (C), and the outermost resin layer (D), the following resins are used, respectively, to form each layer The resin and resin mixture to form were adjusted.

<Heat seal layer (A)>

Linear low-density polyethylene (density: 0.920 g/cm 3 , melting point 110° C., MFR: 5 g/10 min (190° C., 21.18 N); hereinafter referred to as “LLDPE (1)”) 100 parts by mass

<Cyclic olefin resin layer (B)>

Ring-opening polymer of norbornene monomer ("Aperu APL8008T" manufactured by Mitsui Chemicals Co., Ltd., MFR: 15 g/10 min (260 ° C, 21.18 N), glass transition point: 70 ° C; hereinafter "COC (1) 50 parts by mass, ring-opening polymer of norbornene-based monomer ("Aperu APL6015T" manufactured by Mitsui Chemicals, Inc., MFR: 10 g/10 min (260°C, 21.18 N), glass transition point: 145°C ; Hereinafter referred to as "COC (2)") 50 parts by mass

<Middle Layer (C)>

Linear medium-density polyethylene (density: 0.930 g/cm 3 , melting point 125° C., MFR: 5 g/10 min (190° C., 21.18 N); hereinafter referred to as “LMDPE”) 100 parts by mass

<Outer layer (D)>

COC (1) 50 parts by mass, COC (2) 50 parts by mass

These resins were respectively extruders for the heat seal layer (A) (diameter: 50 mm), cyclic olefin resin layer (B) extruder (diameter: 50 mm), intermediate layer (C) extruder (diameter: 50 mm), outermost layer (D ) is supplied to an extruder (diameter: 40 mm) and melted at 200 to 250 ° C., and the melted resin is co-extruded multilayer film manufacturing apparatus of the T-die chilled roll method having a feed block (feed block and T-die temperature: 250 ° C. ), respectively, to perform co-melting extrusion, and the layer structure of the film is a 4-layer structure of (A) / (B) / (C) / (D), and the thickness of each layer is 3 μm / 6 μm / 15 μm / After obtaining a coextruded multilayer film of 6 μm (total of 30 μm), corona treatment was performed on the surface of the outermost layer (D). The surface tension of the corona-treated surface by the wetting reagent was 42 dyne/cm.

After coating the urethane-based adhesive on the corona-treated surface side so as to be 3.5 g/m 2 , a biaxially stretched polyester film (thickness 12 μm, melting point 260° C., manufactured by Toyobo) was dry laminated to obtain a laminated film.

(Example 2)

A co-extruded multilayer film was prepared in the same manner as in Example 1, except that the resin components used for the cyclic olefin resin layer (B) and the outermost layer (D) were described below, and the surface layer (D) was corona treated. conducted. The surface tension of the corona-treated surface by the wetting reagent was 42 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

50 parts by mass of COC (1), 47 parts by mass of COC (2), linear low-density polyethylene (density: 0.920 g/cm 3 , melting point 120° C., MFR: 5 g/10 min (190° C., 21.18 N); hereinafter “LLDPE”) (2)”) 3 parts by mass

<Outer layer (D)>

COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 3 parts by mass

(Example 3)

A co-extruded multilayer film was produced in the same manner as in Example 1, except that the resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) was prepared, and the surface of the surface layer (D) was corona treated. . The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (1) 60 parts by mass, COC (2) 40 parts by mass

<Outer layer (D)>

COC (1) 60 parts by mass, COC (2) 37 parts by mass, LLDPE (2) 3 parts by mass

(Example 4)

A co-extruded multilayer film was produced in the same manner as in Example 1, except that the resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) was prepared, and the surface of the surface layer (D) was corona treated. . The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (1) 70 parts by mass, COC (2) 27 parts by mass, LLDPE (2) 3 parts by mass

<Outer layer (D)>

COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 3 parts by mass

(Example 5)

A co-extruded multilayer film was produced in the same manner as in Example 1, except that the resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) was prepared, and the surface of the surface layer (D) was corona treated. . The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. On the treated surface side, in the same manner as in Example 1, a biaxially stretched polyamide film (thickness: 15 μm, melting point: 260° C., manufactured by Unitika Co., Ltd.) was dry laminated to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 3 parts by mass

<Outer layer (D)>

COC (1) 60 parts by mass, COC (2) 37 parts by mass, LLDPE (2) 3 parts by mass

(Example 6)

A co-extruded multilayer film was produced in the same manner as in Example 1, except that the resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) was prepared, and the surface of the surface layer (D) was corona treated. . The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (1) 60 parts by mass, ring-opening polymer of norbornene monomer ("Aperu AP6013T" manufactured by Mitsui Chemicals, Inc., MFR: 15 g/10 min (260°C, 21.18 N), glass transition point: 125°C ; Hereinafter referred to as "COC (3)") 37 parts by mass, LLDPE (2) 3 parts by mass

<Outer layer (D)>

COC (1) 70 parts by mass, COC (2) 30 parts by mass

(Example 7)

A co-extruded multilayer film was produced in the same manner as in Example 1 except that the resin components used for the cyclic olefin resin layer (B), the intermediate layer (C) and the outermost layer (D) were set, and on the surface of the surface layer (D) Corona treatment was performed. The surface tension of the corona-treated surface by the wetting reagent was 45 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (1) 50 parts by mass, COC (3) 47 parts by mass, LLDPE (2) 3 parts by mass

<Middle Layer (C)>

LLDPE (2) 100 parts by mass

<Outer layer (D)>

COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 5 parts by mass

(Example 8)

The same process as in Example 2 was performed except that the thickness of each layer was (A)/(B)/(C)/(D) = 5 µm/6 µm/16 µm/3 µm (total 30 µm). An extruded multilayer film was produced, and corona treatment was performed on the surface of the surface layer (D). The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

(Example 9)

A co-extruded multilayer film was produced in the same manner as in Example 1, except that the resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) was prepared, and the surface of the surface layer (D) was corona treated. . The surface tension of the corona-treated surface by the wetting reagent was 42 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (1) 27 parts by mass, COC (2) 70 parts by mass, LLDPE (2) 3 parts by mass

<Outer layer (D)>

COC (1) 27 parts by mass, COC (2) 70 parts by mass, LLDPE (2) 3 parts by mass

(Example 10)

A co-extruded multilayer film was produced in the same manner as in Example 1, except that the resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) was prepared, and the surface of the surface layer (D) was corona treated. . The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (1) 20 parts by mass, COC (2) 80 parts by mass

<Outer layer (D)>

COC (2) 100 parts by mass

(Example 11)

The resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) is set, and the thickness of each layer is (A) / (B) / (C) / (D) = 7 μm / 6 μm / A co-extruded multilayer film was produced in the same manner as in Example 1 except that the thickness was co-extruded to be 14 μm/3 μm (total 30 μm), and the surface layer (D) surface was corona-treated. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (2) 97 parts by mass, LLDPE (2) 3 parts by mass

<Outer layer (D)>

COC (1) 17 parts by mass, COC (2) 80 parts by mass, LLDPE (2) 3 parts by mass

(Example 12)

A co-extruded multilayer film was produced in the same manner as in Example 1, except that the resin component used for the cyclic olefin resin layer (B) and the outermost layer (D) was prepared, and the surface of the surface layer (D) was corona treated. . The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Cyclic olefin resin layer (B)>

COC (2) 50 parts by mass, LLDPE (2) 50 parts by mass

<Outer layer (D)>

COC (1) 50 parts by mass, LLDPE (2) 50 parts by mass

(Example 13)

A co-extruded multilayer film was prepared in the same manner as in Example 2, except that the resin component used for the heat seal layer (A) was prepared, and the surface of the surface layer (D) was corona treated. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Heat seal layer (A)>

Linear low-density polyethylene (density: 0.905 g/cm 3 , melting point 95° C., MFR: 4 g/10 min (190° C., 21.18 N); hereinafter referred to as “LLDPE (3)”) 100 parts by mass

(Example 14)

A co-extruded multilayer film was prepared in the same manner as in Example 2, except that the resin component used for the heat seal layer (A) was prepared, and the surface of the surface layer (D) was corona treated. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Heat seal layer (A)>

LLDPE (1) 90 parts by mass, COC (2) 10 parts by mass

(Example 15)

A co-extruded multilayer film was prepared in the same manner as in Example 2, except that the resin component used for the heat seal layer (A) was prepared, and the surface of the surface layer (D) was corona treated. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne/cm. A biaxially stretched polyester film was dry laminated on the treated surface side in the same manner as in Example 1 to obtain a laminated film.

<Heat seal layer (A)>

LLDPE (1) 70 parts by mass, COC (2) 30 parts by mass

(Example 16)

A coextruded multilayer film was prepared in the same manner as in Example 1, and corona treatment was performed on the surface of the surface layer (D). The surface tension of the corona-treated surface by the wetting reagent was 42 dyne/cm. After applying a urethane-based adhesive to the corona treatment surface side so as to be 3.5 g / m 2, an aluminum foil (12 μm) and a biaxially oriented polyester film (thickness 12 μm, melting point 260 ° C., manufactured by Toyobo) are dry laminated in advance. The aluminum foil side of the film Dry lamination was performed to obtain a laminated film.

(Comparative Example 1)

Corona treatment was performed on one side of a polyacrylonitrile-based resin film (Hytron BX, manufactured by Tama Poly Co., Ltd., thickness 20 μm), and a biaxially stretched polyester film was dry-laminated on the corona-treated surface side in the same manner as in Example 1, and the laminated film got

(Comparative Example 2)

Ethylene Vinyl Alcohol Copolymer Resin Film

Corona treatment was performed on one side of (Evar Film EF-E, manufactured by Claresha, thickness 30 μm), and biaxially stretched polyester was dry laminated on the corona treatment surface side in the same manner as in Example 1 to obtain a laminated film.

(Comparative Example 3)

Corona treatment was performed on one side of an LLDPE copolymer resin film (DIFARENL3500T, manufactured by DIC Co., Ltd., thickness 30 μm), and biaxially stretched polyester was dry-laminated on the corona-treated surface side in the same manner as in Example 1 to obtain a laminated film.

The following evaluation was performed about the film obtained by the said Example and comparative example. The obtained results are shown in the table below.

[Tear test]

The obtained laminated film was cut into test pieces each having a size of 63 mm x 76 mm in accordance with JIS K7128, and the tear strength was measured using an Elmendorf tear tester (manufactured by Tester Sangyo Co., Ltd.). From the obtained tear strength, cutability was evaluated according to the following criteria.

○: Tear strength is less than 110

×: Tear strength is 110 or more

[Adsorption test]

After creating a three-way seal pouch of 100 mm in length x 100 mm in width for each laminate film, the mass was measured, and 2 g of methyl salicylate (adsorption test 1) and chlorine dioxide [creperin gel: daikoyakuhin] (adsorption test 2) and the opening was sealed with a heat seal. After being left in an airtight container at a constant temperature of 25°C for 4 weeks, the pouch was opened to remove the contents, and the mass of the pouch was measured, and the adsorption rate was determined from the change rate.

◎ : less than 2%

○: Value 2% or more and less than 5%

×: value 5% or more

[Improperty sealing property (1)]

On the seal layer surface of the laminate film prepared above, an anti-inflammatory analgesic solution (Anmerz: manufactured by Kobayashi Seiyaku Co., Ltd.) was applied with a cotton swab, and after 3 minutes, the seal surfaces were separated (seal temperature: 150 ° C., seal pressure: 0.2 MPa, seal time: 1 second) Sealed. Strength was measured before and after application, and the rate of decrease in strength was determined.

[Improperty sealing property (2)]

Soluble starch (research reagent: manufactured by As One) was spread with a cotton swab on the seal layer surface of the laminate film prepared above, and after 3 minutes, the seal surfaces were sealed (seal temperature: 150 ° C, seal pressure: 0.4 MPa, seal time: 1 second) did. Strength was measured before and after application, and the rate of decrease in strength was determined.

◎ : Less than 10%

○: 10% to 20%

×: 20% or more

[Packaging machine aptitude]

A four-way seal pouch having a length of 45 mm and a width of 85 mm was created using a vertical pillow packaging machine (manufactured by Sankogi Kaisha) for each laminated film, while changing the sealing temperature. Seal strength was measured.

◎: 20 N/15 mm or more

○: 15 to 20

×: Less than 15 N/15 mm

[Pinhole and dart properties]

After preparing 5 three-way seal pouches of 75 mm in length x 55 mm in width for each laminate film, 5 pieces of salon pass (manufactured by Hisamitsu Seyaku) were sealed, and the opening was opened (seal temperature: 150 ° C., seal pressure: 0.5 MPa, sealing time: 1 second) Heat-sealed. After leaving the airtight packaging bag at a constant temperature of 25°C for 2 hours, it was opened to remove the contents, and pinholes and darts (seal leakage) were inspected with a seal checker liquid.

◎: No pinholes or darts

○: Pinhole, 2 darts or less

×: Pinhole, 3 or more darts

[Table 1]

[Table 2]

As is clear from the table above, the packaging structures of Examples 1 to 16 of the present invention can suitably suppress volatilization of the active ingredient while having suitable tear resistance and a wide seal suitability temperature range, and Even when adhesion of foreign matter occurred, it was excellent in suitable impurity sealing property in which adhesion failure did not occur easily. In addition, pinholes and darts were less likely to occur, and the packaging machine aptitude was also excellent.

Claims (8)

As a packaging structure for packaging the patch with a packaging material,
A layer serving as the innermost surface of the packaging structure of the packaging material is a heat-sealable resin layer (A) containing an olefin-based resin,
A resin layer (B) containing a cyclic polyolefin-based resin is provided on the outside of the heat-sealable resin layer (A),
The resin layer (B) containing the cyclic polyolefin-based resin contains a low-Tg cyclic polyolefin-based resin having a glass transition point (Tg) of less than 100°C,
The content of the low-Tg cyclic polyolefin resin is 50% by mass or more in the resin component contained in the resin layer (B) containing the cyclic polyolefin resin,
A resin layer (C) containing an olefin resin is included as an outer layer of the resin layer (B) containing the cyclic polyolefin resin,
The thickness of the resin layer (C) containing the olefin resin is 13 to 20 μm,
A packaging structure for a patch characterized in that the heat-sealing resin layer (A) and the resin layer (B) containing a cyclic polyolefin-based resin are directly laminated. According to claim 1,
A packaging structure in which a resin layer (D) containing a cyclic polyolefin resin is laminated on an outer layer of the resin layer (C) containing the olefin resin. According to claim 1,
The packaging structure of the patch whose content of cyclic polyolefin resin in the resin component contained in the resin layer (B) containing the said cyclic polyolefin resin is 80 mass % or more. According to claim 2,
The packaging structure of the patch whose content of cyclic polyolefin resin in the resin component contained in the resin layer (D) containing the said cyclic polyolefin resin is 80 mass % or more. According to any one of claims 1 to 4,
The heat-sealable resin layer (A) containing the olefin-based resin contains linear low-density polyethylene at 80% by mass or more of the resin components contained in the heat-sealable resin layer (A) containing the olefin-based resin. packaging structure. According to claim 5,
A packaging structure of a patch wherein the linear low-density polyethylene has a density of 0.905 g/cm 3 to 0.925 g/cm 3 . According to any one of claims 1 to 4,
A packaging structure of a patch wherein the thickness of the heat-sealable resin layer (A) containing the olefin-based resin is 2 to 8 μm. According to any one of claims 1 to 4,
The packaging structure of the patch whose content of the cyclic polyolefin resin in the heat-sealing resin layer (A) containing the said olefin resin is 10 mass % or less.