JP6331116B2 - Patch packaging structure - Google Patents

Description

  The present invention relates to a packaging structure for packaging a patch with a packaging material.

  Patches to be applied to the skin surface are widely used for the purpose of administering a transdermally absorbable component into the body, protecting wounds, and the like. Such a patch is usually packaged with a packaging material in order to prevent deterioration of the pasting performance due to oxygen and moisture in the air and volatilization of transdermally absorbable components such as drugs.

  In the packaging structure of patches, packaging using polyacrylonitrile resin as the innermost layer of the packaging material for packaging patches because of the low adsorptivity of the percutaneous absorption component and the ease of opening the packaging structure The structure is widely used (see, for example, Patent Documents 1 and 2).

International Publication No. 2005/072675 JP 2009-160389 A

  However, in the packaging structure using the polyacrylonitrile resin as described above, the sealing suitability temperature range when forming the packaging structure by heat sealing is narrow, and it may be difficult to ensure the sealing strength depending on the bag making conditions. . In addition, the above packaging structure makes it difficult to obtain adhesion when foreign matter adheres to the heat seal surface, such as adhesion of liquid or powder during heat sealing, resulting in decreased yield due to poor adhesion during the production process. May occur.

  The problems to be solved by the present invention include a wide sealing suitability temperature range, and a heat seal that has a reduction in adhesive performance of the patch, suppression of volatilization of transdermal absorption components, and openability of the packaging structure. It is an object of the present invention to provide a packaging structure of a patch excellent in a favorable contaminant sealing property in which poor adhesion is not easily generated even when foreign matter adheres to a surface.

  In the present invention, in the packaging structure in which the patch is packaged with the packaging material, the layer that is the innermost surface in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin resin, and the outer side of the heat-sealable resin layer. The above problem has been solved by a packaging structure of a patch in which a resin layer containing a cyclic polyolefin resin is provided and a heat-sealable resin layer and a resin layer containing a cyclic polyolefin resin are directly laminated.

  That is, the present invention is a packaging structure in which the patch is packaged with a packaging material, the innermost layer in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin resin, and the heat seal Provided is a packaging structure for a patch having a resin layer containing a cyclic polyolefin resin on the outside of the adhesive resin layer, and wherein the heat-sealable resin layer and a resin layer containing a cyclic polyolefin resin are directly laminated. Is.

  The packaging structure of the patch of the present invention is such that a heat seal layer in contact with the patch when packaging the patch is a resin layer containing an olefin resin, and a resin layer containing a cyclic polyolefin resin is included in the resin layer. By having a directly laminated packaging structure, it is suitable for a wide range of temperatures, while having a suitable inhibitory effect on the deterioration of the patch application performance and the volatilization of the transdermally absorbable component, and suitable openability by tearing. Sealing suitability can be ensured, and it is possible to realize a suitable foreign matter sealing property that hardly causes poor adhesion even when foreign matter such as liquid or powder adheres during heat sealing.

  Further, according to the packaging structure of the present invention having the above-described configuration, it is excellent in automatic packaging machine suitability, and suitable foreign matter sealability is less likely to cause poor adhesion when foreign matter such as liquid bite or powder adheres during heat sealing. Can be realized. In addition, the heat seal strength necessary for the integrated packaging in which several patches are packaged can be expressed. Since a level difference occurs due to the thickness (height) of several patches, the occurrence of pinholes and darts (leakage and sealing failure) at the corners of the packaging bag can be suppressed. Further, since the inner surface can be heat-sealed with polyethylene resin, it can be heat-sealed even with a polyethylene chuck used when opening and closing many times after opening.

  The packaging structure of the present invention is a packaging structure in which the patch is packaged with a packaging material, and the innermost layer in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin resin, and the heat-sealable resin The packaging structure has a resin layer containing a cyclic polyolefin resin outside the layer, and a heat-sealable resin layer and a resin layer containing a cyclic polyolefin resin are directly laminated.

[Packaging materials]
The packaging material used for the packaging structure of the present invention is a heat-sealable resin layer (hereinafter referred to as a heat-seal layer (A)) in which the outermost surface layer in the packaging structure contains an olefin-based resin, and the heat. The sealing layer (A) has a structure in which a resin layer containing a cyclic polyolefin resin (hereinafter referred to as a cyclic polyolefin resin layer (B)) is directly laminated.

(Heat seal layer (A))
As the olefin resin used for the heat seal layer (A), polyethylene resin, polypropylene resin, and copolymers thereof can be used. Examples of polyethylene resins include very low density polyethylene (VLDPE), linear low density polyethylene (LLDPE), linear medium density polyethylene (LMDPE), low density polyethylene (LDPE), medium density polyethylene (MDPE), high Polyethylene resin of density polyethylene (HDPE), ethylene-vinyl acetate copolymer (EVA), ethylene-methyl methacrylate copolymer (EMMA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate (EMA) ) Copolymers, ethylene copolymers such as ethylene-ethyl acrylate-maleic anhydride copolymer (E-EA-MAH), ethylene-acrylic acid copolymer (EAA), ethylene-methacrylic acid copolymer (EMAA), etc. Polymer; further ethylene-acrylic acid copolymer Ionomers, ethylene - mentioned ionomer methacrylic acid copolymer, and, alone, may be used by mixing two or more kinds. Among them, suppression of volatilization of percutaneously absorbable components and deterioration of patch application performance (hereinafter sometimes referred to as volatilization of active ingredients), heat such as a wide temperature range suitable for heat sealing and suitable adhesion LLDPE can be preferably used because it is easy to suitably realize the sealing property.

  The LDPE may be a branched low density polyethylene obtained by a high pressure radical polymerization method, and is preferably a branched low density polyethylene obtained by homopolymerizing ethylene by a high pressure radical polymerization method.

  As LLDPE and LMDPE, an ethylene monomer as a main component and a comonomer such as butene-1, hexene-1, octene-1, and 4-methylpentene are produced by a low-pressure radical polymerization method using a single site catalyst. -Copolymerized olefin. As a comonomer content rate, it is preferable that it is the range of 0.5-20 mol%, and it is more preferable that it is the range of 1-18 mol%.

  Examples of the single-site catalyst include various single-site catalysts such as metallocene catalyst systems such as combinations of metallocene compounds of Group IV or V transition metals and organoaluminum compounds and / or ionic compounds. In addition, the single-site catalyst has a uniform active site, so the molecular weight distribution of the resulting resin is sharper than a multi-site catalyst with a non-uniform active site. This is preferable because a resin having physical properties excellent in stability of adhesive strength between resin layers can be obtained.

The MFR (190 ° C., 21.18 N) of the polyethylene resin is preferably 2 to 20 g / 10 minutes, and more preferably 3 to 10 g / 10 minutes. When the MFR is within this range, the extrusion moldability of the film is improved. The density of the LLDPE, packaging suitability, contaminants sealability, preferably 0.905g ^/ cm ³ ~0.925g ^/ cm 3 from the pinhole resistance, since particularly easily suitably suppressed volatilization or the like of the active ingredient 0. and particularly preferably ^{915g / cm 3 ~0.925g / cm 3} .

  Examples of the polypropylene resin include propylene homopolymer, propylene / α-olefin random copolymer, such as propylene-ethylene copolymer, propylene-butene-1 copolymer, propylene-ethylene-butene-1 copolymer. Examples include coalesced metallocene catalyst polypropylene. These may be used alone or in combination. A propylene-α-olefin random copolymer is desirable, and a propylene / α-olefin random polymer polymerized using a metallocene catalyst is particularly preferable. When these polypropylene resins are used as the intermediate layer (B), the heat resistance of the film is improved and the softening temperature can be increased. Therefore, boiling at 100 ° C. or lower, hot filling, or 100 ° C. or higher. It can be suitably used as a laminating film for packaging materials having excellent steam / high pressure heat sterilization characteristics such as retort sterilization.

  These polypropylene resins preferably have an MFR (230 ° C.) of 0.5 to 30.0 g / 10 min and a melting point of 110 to 165 ° C., more preferably an MFR (230 ° C.) of 2 0.0-15.0 g / 10 min, melting point is 115-162 ° C. If MFR and melting | fusing point are this range, the film-forming property of a film will improve.

The heat seal layer (A) is preferably composed mainly of an olefin-based resin because it is easy to ensure a wide heat seal suitability temperature range and easy to achieve suitable adhesion. 80% by mass or more in the resin component that constitutes) is preferably an olefin resin other than the cyclic olefin resin exemplified above, more preferably 90% by mass or more, and 100% by mass. Is particularly preferred. Moreover, since 80 mass% in the olefin resin contained in the heat seal layer (A) is an olefin resin having a density of 0.9 g / cm ³ or more, it is particularly easy to obtain adhesion, and is preferably 90 mass% or more. It is more preferable that In particular, 80% by mass in the olefin-based resin contained in the heat seal layer (A) is preferably a linear low-density polyethylene resin, and more preferably 90% by mass or more.

  In order to suppress the volatilization of active ingredients, it is also preferable to contain a cyclic polyolefin resin in the heat seal layer (A), but it is easy to ensure heat seal properties such as a wide heat seal suitability temperature range and suitable adhesion. Therefore, the content of the cyclic polyolefin resin in the heat seal layer (A) is preferably 10% by mass or less, more preferably 5% by mass or less, and particularly preferably substantially not contained.

  The thickness of the heat seal layer (A) may be appropriately adjusted depending on the use mode, but it is 2 to 8 μm because it is easy to ensure a suitable heat seal property while suitably suppressing volatilization of the active ingredient. Is preferable, and it is more preferable that it is 3-6 micrometers.

(Cyclic polyolefin resin layer (B))
Examples of the cyclic polyolefin resin used for the cyclic polyolefin resin layer (B) include a norbornene polymer, a vinyl alicyclic hydrocarbon polymer, and a cyclic conjugated diene polymer. Among these, norbornene-based polymers are preferable. The norbornene-based polymer includes a ring-opening polymer of a norbornene-based monomer (hereinafter referred to as “COP”), a norbornene-based copolymer obtained by copolymerizing a norbornene-based monomer and an olefin such as ethylene (hereinafter, referred to as “COP”). , “COC”). Furthermore, COP and COC hydrogenates are particularly preferred. The weight average molecular weight of the cyclic olefin resin is preferably 5,000 to 500,000, more preferably 7,000 to 300,000.

  The norbornene polymer and the norbornene monomer used as a raw material are alicyclic monomers having a norbornene ring. Examples of such norbornene-based monomers include norbornene, tetracyclododecene, ethylidene norbornene, vinyl norbornene, ethylidetetracyclododecene, dicyclopentadiene, dimethanotetrahydrofluorene, phenyl norbornene, methoxycarbonyl norbornene, methoxy And carbonyltetracyclododecene. These norbornene monomers may be used alone or in combination of two or more.

  The norbornene-based copolymer is a copolymer of the norbornene-based monomer and an olefin copolymerizable with the norbornene-based monomer, and examples of such olefin include the number of carbon atoms such as ethylene, propylene, and 1-butene. Examples thereof include olefins having 2 to 20; cycloolefins such as cyclobutene, cyclopentene, and cyclohexene; and non-conjugated dienes such as 1,4-hexadiene. These olefins can be used alone or in combination of two or more.

  Examples of the cyclic polyolefin-based resin include commercially available ring-opening polymers (COP) of norbornene monomers such as “ZEONOR” manufactured by Nippon Zeon Co., Ltd., and norbornene copolymers ( Examples of (COC) include “Apel” manufactured by Mitsui Chemicals, Inc., “TOPAS” manufactured by Polyplastics, and the like.

  In the present invention, by using a packaging material having a structure in which the cyclic polyolefin resin layer (B) containing such a cyclic polyolefin resin is directly laminated with the heat seal layer (A), the volatilization of the active ingredient is suitable. It is possible to achieve good tearability of the packaging material while suppressing the above.

  The cyclic polyolefin resin layer (B) is preferably mainly composed of a cyclic polyolefin-based resin because it easily suppresses volatilization of the active ingredient, etc. and easily obtains a suitable opening property by tearing of the packaging material. 60% by mass or more of the resin component constituting the cyclic polyolefin resin layer (B) is preferably a cyclic polyolefin-based resin, more preferably 80% by mass or more, and particularly preferably 90% by mass or more. preferable.

  Moreover, since it is easy to implement | achieve especially the inhibitory effect, such as volatilization of an active ingredient, and unsealing property, 40 mass% or more in the resin component contained in a cyclic polyolefin resin layer (B) has a glass transition point (Tg). It is preferable to use a low Tg cyclic polyolefin resin of 100 ° C. or less, more preferably 50% by mass or more, and particularly preferably 50 to 80% by mass. In the present invention, the glass transition point, melting point, and the like are values measured by differential scanning calorimetry (DSC). The glass transition temperature of the low Tg cyclic polyolefin resin is more preferably 90 ° C. or less, and particularly preferably 60 to 80 ° C.

  It is also preferred to use a high Tg cyclic polyolefin resin having a glass transition point exceeding 100 ° C. together with a low Tg cyclic polyolefin resin having a glass transition point of 100 ° C. or lower. By using a low Tg cyclic polyolefin resin and a high Tg cyclic polyolefin resin in combination, it becomes easy to improve the tensile strength, tear resistance, and the like of the resulting packaging material. The content of the high-Tg cyclic polyolefin-based resin is suitable for improving the tensile strength and tear resistance of the resulting packaging material, and that it is easy to obtain suitable rigidity and contaminant sealing properties, and to suppress pinholes. Therefore, the content is preferably 60% by mass or less, more preferably 50% by mass or less, and particularly preferably 20 to 50% by mass in the resin component contained in the cyclic polyolefin-based resin layer (B). The glass transition temperature of the high-Tg cyclic polyolefin resin is preferably 120 ° C. or higher, more preferably 130 ° C. or higher, and particularly preferably 135 to 150 ° C.

  In addition, in the cyclic polyolefin resin layer (B), a polyolefin resin such as a polypropylene resin or a polyethylene resin that does not contain a cyclic structure may be used in combination in order to improve tear resistance and bag breaking resistance. It is valid. When using these polyolefin-type resin which does not contain a cyclic structure, it is preferable to set it as 20 mass% or less in the resin component contained in a cyclic polyolefin-type resin layer (B), and it is more preferable to set it as 10 mass% or less. Preferably, it is more preferably 5% by mass or less. Further, the lower limit of the content of the polyolefin resin not containing a cyclic structure is preferably 1% by mass or more, and more preferably 2% by mass or more.

  The thickness of the cyclic polyolefin resin layer (B) may be appropriately adjusted depending on the use mode, but it is easy to ensure a suitable contaminant sealing property while suitably suppressing volatilization of the active ingredient, and to prevent pinholes during packaging. Since it is easy to suppress, it is preferable that it is 3-12 micrometers, it is more preferable that it is 4-10 micrometers, and it is especially preferable that it is 5-8 micrometers.

(Layer structure)
The packaging material used in the present invention is a packaging material composed of a laminated film in which at least the heat seal layer (A) and the cyclic polyolefin resin layer (B) are laminated. The layer structure of the laminated film used as the packaging material may be a layer structure of (A) / (B) composed of the heat seal layer (A) and the cyclic polyolefin resin layer (B), but the (B) Other layers such as a resin layer containing an olefin resin (hereinafter referred to as a resin layer (C)) and a cyclic polyolefin resin layer containing a cyclic polyolefin resin (hereinafter referred to as a resin layer (D)) are also provided on the outer layer of the layer. The structure by which the layer was laminated | stacked may be sufficient.

  As a preferable configuration example of a configuration in which these other layers are laminated, for example, a three-layer configuration such as (A) / (B) / (C), (A) / (B) / (D), (A) A four-layer structure of / (B) / (C) / (D) can be exemplified. Especially, the structure of (A) / (B) / (C) / (D) is preferable because it is easy to adjust the performance such as suppression of volatilization of the active ingredient, openability, heat sealability and the like particularly preferably. Note that the layer (A) and the layer (C), the layer (B) and the layer (D) may be layers having the same composition or different compositions.

  In the packaging material used in the present invention, by providing the resin layer (C), the packaging material is suitable for flexibility, cold resistance, impact resistance, pinhole resistance, contaminant sealability, curl resistance, etc. Can be adjusted. For this reason, it is preferable to select suitably the olefin resin used for a resin layer (C) according to a use or a use aspect.

  As the olefin resin used for the resin layer (C), the same olefin resin as that of the heat seal layer (A) can be preferably used. However, it is easy to obtain interlayer adhesion with other layers, and it is easy to obtain industrially. From the viewpoint of properties, a polyethylene resin or a polypropylene resin is preferably used, and a polyethylene resin is particularly preferable.

As the polyethylene resin, those having a density of 0.915 to 0.950 g / cm ³ are preferable because cold resistance, pinhole resistance, interlayer adhesion with a multilayer, and the like are easily obtained, and more preferably, the density The thing of 0.920-0.945g / cm < ³ > can be used preferably. Moreover, it is preferable that melting | fusing point is generally the range of 70-130 degreeC, and 80-125 degreeC is more preferable. If melting | fusing point is this range, processing stability and coextrusion workability with the said cyclic polyolefin resin (a) will improve. Moreover, it is preferable that it is 2-20 g / 10min, and, as for MFR (190 degreeC, 21.18N) of the said polyethylene-type resin, it is more preferable that it is 3-10 g / 10min. When the MFR is within this range, the extrusion moldability of the film is improved.

  Among polyethylene-based resins, LLDPE and LMDPE can be particularly preferably used because of easy opening by tearing and easy pinhole resistance of the packaging material.

  The polypropylene resin preferably has an MFR (230 ° C.) of 0.5 to 30.0 g / 10 min and a melting point of 110 to 165 ° C., more preferably an MFR (230 ° C.) of 2. The melting point is 115 to 162 ° C. at 0 to 15.0 g / 10 minutes. If MFR and melting | fusing point are this range, the film-forming property of a film will improve.

  The content of the olefin resin in the resin layer (C) is preferably 80% by mass or more of the resin component constituting the resin layer (C), more preferably 90% by mass or more. preferable.

  Moreover, you may mix other resin other than an olefin resin in the range which does not impair the effect of this invention. As other resins that can be mixed and used at this time, it is preferable that a coextrusion lamination method such as the above-mentioned cyclic polyolefin resin can be applied.

  The thickness of the resin layer (C) may be appropriately adjusted depending on the use mode, but it is preferably 10 to 30 μm and preferably 13 to 20 μm because it is easy to obtain suitable packaging suitability and contaminant sealing properties. More preferred.

  The packaging material used for this invention can suppress suitably the adhesive component at the time of laminating | stacking a base material which is mentioned later by the said structure, and transfer to patches, such as printing ink at the time of providing a printing layer. However, it can suppress especially suitably by providing a resin layer (D). Further, it is preferable because the curl resistance and the like can be easily adjusted.

  As the cyclic polyolefin resin used for the resin layer (D), the same cyclic polyolefin resin as that of the cyclic polyolefin resin layer (B) can be preferably used.

  The resin layer (D) preferably contains a cyclic polyolefin resin as a main component, and 80% by mass or more of the resin components constituting the resin layer (C) is preferably a cyclic polyolefin resin, and 90% by mass. More preferably.

  In addition, the glass transition point of the cyclic polyolefin resin used for the resin layer (D) is 200 from the viewpoint of easy production by a coextrusion lamination method with other resin layers and the availability of industrial raw materials. It is preferable that it is below ℃. As such cyclic polyolefin resin having Tg, the content ratio of norbornene monomer is preferably in the range of 40 to 90% by mass, more preferably 50 to 90% by mass, and still more preferably 60 to 85%. % By mass. If the content ratio is within this range, it is easy to improve rigidity, easy tearability, and laminate characteristics.

  Moreover, since it is easy to suppress the transfer from the contents to the laminate layer of low molecular weight compounds, volatile components, etc., a high Tg cyclic polyolefin resin having a glass transition point exceeding 100 ° C. is applied to the resin layer (D). It is preferable to set it as 20-60 mass% in the resin component contained, and it is more preferable to set it as 20-50 mass%. By setting it as the said range, since it is easy to improve the easy tear property and rigidity of the packaging material obtained, it is preferable. The glass transition temperature of the high-Tg cyclic polyolefin resin is preferably 120 ° C. or higher, more preferably 130 ° C. or higher, and particularly preferably 135 to 150 ° C.

  On the other hand, norbornene copolymers with high Tg have low tensile strength, and are extremely easy to break and tear easily. Therefore, take into consideration the balance between film formability, slitting take-up and winding properties, and laminate strength. It is also preferable to blend a low Tg cyclic polyolefin resin having a glass transition point of 100 ° C. or lower with a high Tg cyclic polyolefin resin. In particular, it is preferable to blend COC having a Tg of less than 100 ° C. in order to develop high seal strength and to improve bag breaking resistance. The content of the low-Tg cyclic polyolefin resin is more preferably 50% by mass or more, and particularly preferably 50 to 80% by mass in the resin component contained in the resin layer (D). The glass transition temperature of the low Tg cyclic polyolefin resin is more preferably 90 ° C. or less, and particularly preferably 60 to 80 ° C.

  It is also effective to blend a polyolefin resin such as a polypropylene resin or a polyethylene resin that is compatible with COC and does not contain a cyclic structure into the resin layer (D). When using these polyolefin-type resin which does not contain a cyclic structure, it is preferable to set it as 20 mass% or less in the resin component contained in a cyclic polyolefin-type resin layer (B), and it is more preferable to set it as 10 mass% or less. Preferably, it is more preferably 5% by mass or less. Further, the lower limit of the content of the polyolefin resin not containing a cyclic structure is preferably 1% by mass or more, and more preferably 2% by mass or more.

  The thickness of the resin layer (D) may be appropriately adjusted depending on the use mode, but is preferably 1 to 10 μm and more preferably 2 to 8 μm because it is easy to produce by the coextrusion lamination method. It is preferably 2 to 5 μm.

  Since the laminated film used for the packaging material suitably suppresses the volatilization of the active ingredient, etc., and it is easy to obtain suitable heat sealability and unsealing properties, and it becomes easy to laminate with other substrates. The total thickness is preferably in the range of 10 to 100 μm, more preferably in the range of 20 to 60 μm.

  When the four-layer structure of (A) / (B) / (C) / (D) is used as the layer structure of the packaging material, it is easy to obtain a suitable heat-sealing property, and volatilization of the active ingredient is suitably suppressed. Since it is easy to do, it is preferable that the thickness ratio with respect to the total thickness of a layer (A) is 10 to 25%, and it is more preferable that it is 10 to 20%. Moreover, since it is easy to suppress volatilization of an active ingredient, etc. and it is easy to obtain favorable openability, it is preferable to make the thickness ratio with respect to the total thickness of a layer (B) 15-30%. Moreover, since it is easy to obtain favorable openability, it is preferable that the ratio of the total thickness of the layer (D) and the layer (B) to the total thickness is 40% or more and 60% or less. Further, the total thickness of the cyclic polyolefin resin layer (B) and the resin layer (C) may be adjusted as appropriate depending on the use mode, but it is easy to ensure suitable openability while suitably suppressing volatilization of the active ingredient. Therefore, the thickness is preferably 6 to 15 μm, and more preferably 8 to 13 μm.

  For each of the resin layers, an antifogging agent, an antistatic agent, a heat stabilizer, a nucleating agent, an antioxidant, a lubricant, an antiblocking agent, a release agent, an ultraviolet absorber, a coloring agent, etc. These components can be added as long as the object of the present invention is not impaired. In particular, in order to impart processing suitability during film forming and packaging suitability of the filling machine, the friction coefficient on the film surface of the layers (A) and (D) is preferably 1.5 or less, and more preferably 1.0 or less. It is preferable to add a lubricant or an anti-blocking agent to the resin layer (A) as appropriate.

  The production method of the laminated film is not particularly limited. For example, each resin or resin mixture used for each layer is heated and melted in a separate extruder, and melted by a method such as a coextrusion multilayer die method or a feed block method. A coextrusion method in which each layer is laminated in a state and then formed into a film by inflation, a T-die / chill roll method, or the like can be preferably used. The co-extrusion method is preferable because the thickness ratio of each layer can be adjusted relatively freely, and a laminated film having excellent hygiene and cost performance can be obtained. Further, when a low-density polyethylene resin is used for the layer containing the cyclic polyolefin resin used in the present invention and the resin layer to be laminated, the difference between the melting point and Tg between the two is large. The appearance may be deteriorated, and it may be difficult to form a uniform layer structure. In order to suppress such deterioration, a T-die / chill roll method that can perform melt extrusion at a relatively high temperature is preferable.

  The packaging material used in the present invention may be a packaging material composed of the above laminated film, but the laminated film is used as a sealant film, and a substrate is bonded to the layer (A) of the sealant film and the other outer layer. A packaging material made of a laminated film is preferable. As the substrate, it is preferable to use a plastic substrate having high rigidity and high gloss, particularly a biaxially stretched resin film. For applications that do not require transparency, aluminum foils can be used alone or in combination.

  Examples of the stretched resin film include biaxially stretched polyester (PET), easily tearable biaxially stretched polyester (PET), biaxially stretched polypropylene (OPP), and biaxially stretched polyamide (from the viewpoint of easy tearability, etc. PA), coextrusion biaxially oriented polypropylene with ethylene vinyl alcohol copolymer (EVOH) as the central layer, biaxially oriented biaxially oriented polypropylene, biaxially oriented ethylene vinyl alcohol copolymer (EVOH), and coextrusion biaxially coated with polyvinylidene chloride (PVDC) Examples thereof include stretched polypropylene. These may be used alone or in combination.

  The laminate film is a film obtained by laminating the base material on the laminated film obtained by the above production method. Examples of the lamination method include methods such as dry lamination, wet lamination, non-solvent lamination, and extrusion lamination. Can be mentioned.

  Examples of the adhesive used in the dry lamination include a polyether-polyurethane adhesive and a polyester-polyurethane adhesive. Various pressure-sensitive adhesives can be used, but a pressure-sensitive pressure-sensitive adhesive is preferably used. Examples of the pressure-sensitive adhesive include, for example, a polyisobutylene rubber, a butyl rubber, a rubber adhesive obtained by dissolving a mixture thereof in an organic solvent such as benzene, toluene, xylene, hexane, or a bisethylene acid rosin in the rubber adhesive. A blend of tackifiers such as ester, terpene / phenol copolymer, terpene / indene copolymer, or 2-ethylhexyl acrylate / n-butyl acrylate copolymer, 2-ethylhexyl acrylate / ethyl acrylate / Examples thereof include an acrylic pressure-sensitive adhesive prepared by dissolving an acrylic copolymer having a glass transition point of −20 ° C. or less such as a methyl methacrylate copolymer in an organic solvent.

  When laminating a base material, the outermost surface on which the base material of the above laminated film is laminated is to improve the applicability of the above-mentioned adhesive or pressure-sensitive adhesive or after printing on the outermost surface. In the case of laminating with a base material, it is preferable to perform a surface treatment in order to improve adhesion to an adhesive, a pressure-sensitive adhesive, printing ink, and the like. Examples of such surface treatment include corona treatment, plasma treatment, chromic acid treatment, flame treatment, hot air treatment, surface oxidation treatment such as ozone / ultraviolet treatment, and surface unevenness treatment such as sandblasting. Corona treatment is preferable. If the surface on which the base material is laminated is a layer containing a cyclic polyolefin resin, there is no deterioration over time in the degree of treatment even after long-term storage after such treatment. Can be provided.

[Patch]
The patch in the present invention is a dressing, a poultice, a plaster, a dressing, a percutaneous absorption tape preparation, etc. used by being applied to the skin of a human body or an animal for administration of a drug or the like and protection of a wound. It is a patch. As a form of the patch, a form in which a pressure-sensitive adhesive layer is provided on one side or both sides of the support can be preferably exemplified, and a transdermal component such as a drug is contained in the pressure-sensitive adhesive layer as necessary. A release liner may be provided on the surface of the pressure-sensitive adhesive layer. According to the packaging structure of the present invention, when such a patch is used, volatilization of the active ingredient can be suitably suppressed.

  As the support for use in the patch, those that are difficult to permeate the percutaneous absorption component contained in the adhesive layer can be preferably used. Examples of such a support include resin films such as polyester, nylon, polyethylene, polypropylene, polyvinyl chloride, ethylene-ethyl acrylate copolymer, polytetrafluoroethylene, and metal foil. Moreover, the film which laminated | stacked these films etc. suitably may be sufficient. The thickness of the support is preferably 10 to 500 μm, more preferably 10 to 200 μm.

  The pressure-sensitive adhesive used for the pressure-sensitive adhesive layer can be used without particular limitation as long as it has adhesiveness to the skin. Examples of such adhesives include acrylic adhesives, rubber adhesives such as SIS (styrene-isoprene-styrene), SBS (styrene-butadiene-styrene), polyisoprene, and polybutadiene, silicone adhesives, and vinyl. An ester adhesive, a polyester adhesive, etc. can be illustrated. Among them, an acrylic pressure-sensitive adhesive can be preferably used because it is easy to contain a large amount of a transdermal absorption component and the like in the pressure-sensitive adhesive and it is easy to obtain a suitable adhesive property to the skin. A rubber-based pressure-sensitive adhesive is preferable because stability of a transdermal absorption component and the like is easily obtained.

  As the percutaneous absorption component to be contained in the adhesive layer, various physiologically active components can be used depending on the use, for example, anesthetics, sedatives, antiepileptics, antipyretic analgesics, antipruritics, antipsychotics, and neuropsychiatric agents. Drugs, skeletal muscle relaxants, autonomic drugs, antihistamines, cardiotonic drugs, arrhythmic drugs, diuretics, antihypertensive drugs, vasoconstrictors, coronary vasodilators, peripheral vasodilators, arteriosclerosis drugs, circulation Medicines, respiratory stimulants, antitussive expectorants, hormonal drugs, topical suppurative drugs, anti-inflammatory drugs, hemostatic drugs, gout treatment drugs, diabetic drugs, antineoplastic drugs, antibiotics, smoking cessation aids Etc. can be illustrated.

[Packaging structure]
The packaging structure of the present invention is a packaging structure in which the patch is packaged with a packaging material, and the patch is packaged with the heat seal layer (A) of the packaging material as the innermost surface. As the packaging structure, a structure in which the patch is sandwiched between two film-shaped packaging materials and the periphery of the patch is heat-sealed, and folded so that the patch is sandwiched between one film-shaped packaging material, Examples include a structure in which the periphery of the patch is heat-sealed, a packaging structure in which a roll-shaped film is sealed in a cylindrical shape with an automatic packaging machine, and then the top and bottom are sealed.

  Further, in the packaging structure of the present invention, in order to weaken the initial tear strength and improve the unsealing property, an arbitrary tear starting portion such as a V notch, an I notch, a perforation, or a microporous is formed in the seal portion. Also good. In addition, a polyethylene-based chuck that can be opened and closed after opening may be provided in a part of the packaging structure.

  The packaging structure of the present invention is suitable in a wide temperature range with the above-mentioned configuration, while having a suitable inhibitory effect on the deterioration of the adhesive performance of the patch and the volatilization of the transdermally absorbable component, and suitable openability by tearing. It is suitable for patch packaging applications because it can ensure a good sealability and can achieve a good foreign substance sealability that does not cause poor adhesion even when foreign matter such as liquid or powder adheres during heat sealing. Applicable to. Moreover, the packaging material used for the packaging structure of the present invention is excellent in automatic packaging machine suitability, and can realize suitable contaminant sealing properties. In addition, the heat seal strength necessary for the integrated packaging in which several patches are stacked and packaged can be exhibited, and the occurrence of pinholes and darts (leakage and sealing failure) at the corners of the packaging structure can be suppressed. Furthermore, since the heat seal layer on the innermost surface can also heat-seal polyethylene-based resin, it is possible to provide a polyethylene-based chuck that is used when opening and closing many times after opening.

  Next, the present invention will be described in more detail with reference to examples and comparative examples.

Example 1
As the resin component forming each layer of the heat seal layer (A), the cyclic olefin resin layer (B), the intermediate resin layer (C) and the outermost resin layer (D), the following resins are used. The resin and resin mixture forming each layer were prepared.
<Heat seal layer (A)>
Linear low-density polyethylene (density: 0.920 g / cm ³ , melting point 110 ° C., MFR: 5 g / 10 minutes (190 ° C., 21.18 N); hereinafter referred to as “LLDPE (1)”) 100 parts by mass <Cyclic olefin resin layer (B)>
Ring-opening polymer of norbornene-based monomer (“Apel APL8008T” manufactured by Mitsui Chemicals, MFR: 15 g / 10 min (260 ° C., 21.18 N), glass transition point: 70 ° C .; hereinafter referred to as “COC (1)” .) 50 parts by mass, ring-opening polymer of norbornene-based monomer (“Apel APL6015T” manufactured by Mitsui Chemicals, MFR: 10 g / 10 min (260 ° C., 21.18 N), glass transition point: 145 ° C .; COC (2) ") 50 parts by mass <intermediate layer (C)>
Linear medium density polyethylene (density: 0.930 g / cm ³ , melting point 125 ° C., MFR: 5 g / 10 min (190 ° C., 21.18 N); hereinafter referred to as “LMDPE”) 100 parts by mass <outermost layer ( D)>
COC (1) 50 parts by mass, COC (2) 50 parts by mass

  Each of these resins is an extruder for heat seal layer (A) (caliber 50 mm), an extruder for cyclic olefin resin layer (B) (caliber 50 mm), an extruder for intermediate layer (C) (caliber 50 mm), T-die / chill roll co-extrusion multilayer film production apparatus (feed block and T-die) having a feed block that is fed to an outer layer (D) extruder (40 mm in diameter) and melted at 200 to 250 ° C. (Temperature: 250 ° C.) and co-melt extrusion is performed, and the film layer structure is a four-layer structure of (A) / (B) / (C) / (D), and the thickness of each layer is 3 μm / After obtaining a coextruded multilayer film of 6 μm / 15 μm / 6 μm (total 30 μm), the surface of the outermost layer (D) was subjected to corona treatment. The surface tension of the corona-treated surface by the wetting reagent was 42 dyne / cm.

After coating the urethane adhesive on the corona-treated surface side to 3.5 g / m ² , a biaxially stretched polyester film (thickness 12 μm, melting point 260 ° C., manufactured by Toyobo) was dry laminated to obtain a laminate film. .

(Example 2)
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 42 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 50 parts by mass, COC (2) 47 parts by mass, linear low density polyethylene (density: 0.920 g / cm ³ , melting point 120 ° C., MFR: 5 g / 10 min (190 ° C., 21.18 N) Hereinafter referred to as “LLDPE (2)”) 3 parts by mass <outermost layer (D)>
COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 3 parts by mass

(Example 3)
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 60 parts by mass, COC (2) 40 parts by mass <outermost layer (D)>
COC (1) 60 parts by mass, COC (2) 37 parts by mass, LLDPE (2) 3 parts by mass

Example 4
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 70 parts by mass, COC (2) 27 parts by mass, LLDPE (2) 3 parts by mass <outermost layer (D)>
COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 3 parts by mass

(Example 5)
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. In the same manner as in Example 1, a biaxially stretched polyamide film (thickness 15 μm, melting point 260 ° C., manufactured by Unitika Ltd.) was dry laminated on the treated surface side to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 3 parts by mass <outermost layer (D)>
COC (1) 60 parts by mass, COC (2) 37 parts by mass, LLDPE (2) 3 parts by mass

(Example 6)
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 60 parts by mass, ring-opening polymer of norbornene-based monomer (“Appel AP6013T” manufactured by Mitsui Chemicals, MFR: 15 g / 10 min (260 ° C., 21.18 N), glass transition point: 125 ° C .; , "COC (3)") 37 parts by mass, LLDPE (2) 3 parts by mass <outermost layer (D)>
70 parts by weight of COC (1), 30 parts by weight of COC (2)

(Example 7)
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used in the cyclic olefin-based resin layer (B), the intermediate layer (C), and the outermost layer (D) were as follows, and the surface layer (D ) Corona treatment was applied to the surface. The surface tension of the corona-treated surface by the wetting reagent was 45 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 50 parts by mass, COC (3) 47 parts by mass, LLDPE (2) 3 parts by mass <intermediate layer (C)>
LLDPE (2) 100 parts by mass <outermost layer (D)>
COC (1) 50 parts by mass, COC (2) 47 parts by mass, LLDPE (2) 5 parts by mass

(Example 8)
Coextrusion in the same manner as in Example 2 except that the thickness of each layer was (A) / (B) / (C) / (D) = 5 μm / 6 μm / 16 μm / 3 μm (total 30 μm). A multilayer film was prepared, and the surface layer (D) was subjected to corona treatment. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.

Example 9
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 42 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 27 parts by mass, COC (2) 70 parts by mass, LLDPE (2) 3 parts by mass <outermost layer (D)>
COC (1) 27 parts by mass, COC (2) 70 parts by mass, LLDPE (2) 3 parts by mass

(Example 10)
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
COC (1) 20 parts by mass, COC (2) 80 parts by mass <outermost layer (D)>
COC (2) 100 parts by mass

(Example 11)
The resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) are as follows, and the thickness of each layer is (A) / (B) / (C) / (D) = 7 μm / 6 μm / 14 μm / A coextruded multilayer film was produced in the same manner as in Example 1 except that it was coextruded to 3 μm (total 30 μm), and the surface layer (D) was subjected to corona treatment. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
97 parts by mass of COC (2), 3 parts by mass of LLDPE (2) <outermost layer (D)>
COC (1) 17 parts by mass, COC (2) 80 parts by mass, LLDPE (2) 3 parts by mass

(Example 12)
A coextruded multilayer film was prepared in the same manner as in Example 1 except that the resin components used for the cyclic olefin-based resin layer (B) and the outermost layer (D) were as follows, and the surface of the surface layer (D) was subjected to corona treatment. gave. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Cyclic olefin resin layer (B)>
50 parts by mass of COC (2), 50 parts by mass of LLDPE (2) <outermost layer (D)>
COC (1) 50 parts by mass, LLDPE (2) 50 parts by mass

(Example 13)
A coextruded multilayer film was produced in the same manner as in Example 2 except that the resin components used for the heat seal layer (A) were as follows, and the surface layer (D) was subjected to corona treatment. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Heat seal layer (A)>
Linear low-density polyethylene (density: 0.905 g / cm ³ , melting point 95 ° C., MFR: 4 g / 10 minutes (190 ° C., 21.18 N); hereinafter referred to as “LLDPE (3)”) 100 parts by mass

(Example 14)
A coextruded multilayer film was produced in the same manner as in Example 2 except that the resin components used for the heat seal layer (A) were as follows, and the surface layer (D) was subjected to corona treatment. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Heat seal layer (A)>
LLDPE (1) 90 parts by mass, COC (2) 10 parts by mass

(Example 15)
A coextruded multilayer film was produced in the same manner as in Example 2 except that the resin components used for the heat seal layer (A) were as follows, and the surface layer (D) was subjected to corona treatment. The surface tension of the corona-treated surface by the wetting reagent was 43 dyne / cm. A biaxially stretched polyester film was dry laminated on the treated surface in the same manner as in Example 1 to obtain a laminated film.
<Heat seal layer (A)>
LLDPE (1) 70 parts by mass, COC (2) 30 parts by mass

(Example 16)
A coextruded multilayer film was produced in the same manner as in Example 1, and the surface layer (D) was subjected to corona treatment. The surface tension of the corona-treated surface by the wetting reagent was 42 dyne / cm. After applying urethane adhesive on the corona-treated surface to 3.5 g / m ² , dry laminate with aluminum foil (12 μm) and biaxially stretched polyester film (thickness 12 μm, melting point 260 ° C., manufactured by Toyobo) in advance The laminated film was dry laminated with the aluminum foil surface to obtain a laminate fill.

(Comparative Example 1)
One side of a polyacrylonitrile-based resin film (Hitron BX, manufactured by Tamapoly Co., Ltd., thickness 20 μm) is subjected to corona treatment, and a biaxially stretched polyester film is dry-laminated on the corona treatment surface side in the same manner as in Example 1 to obtain a laminate film Got.

(Comparative Example 2)
One side of an ethylene vinyl alcohol copolymer resin film (Eval Film EF-E, manufactured by Kuraray Co., Ltd., thickness 30 μm) is subjected to corona treatment, and a biaxially stretched polyester is dry laminated on the corona treatment surface side in the same manner as in Example 1. Thus, a laminated film was obtained.

(Comparative Example 3)
One side of an LLDPE copolymer resin film (DIFARENL3500T, manufactured by DIC, thickness 30 μm) is subjected to corona treatment, and biaxially stretched polyester is dry-laminated on the corona treatment surface side in the same manner as in Example 1 to obtain a laminate film. It was.

  The following evaluation was performed about the film obtained by the said Example and comparative example. The results obtained are shown in the table below.

[Tearability test]
The obtained laminate film was cut into test pieces each having a size of 63 mm × 76 mm in accordance with JIS K7128, and tear strength was measured using an Elmendorf tear tester (manufactured by Tester Sangyo Co., Ltd.). From the obtained tear strength, hand tearability was evaluated according to the following criteria.
○: Tear strength is less than 110.
X: Tear strength is 110 or more.

[Adsorption test]
After making a three-sided seal pouch with a length of 100 mm x width of 100 mm for each laminate film, and measuring the mass, 2 g of methyl salicylate (adsorption test 1) and chlorine dioxide [Kraepelin gel: Daiko Pharmaceutical] (adsorption test 2) are placed in the opening. Was sealed by heat sealing. After standing in a sealed container for 4 weeks under a constant temperature condition at 25 ° C., the container was opened, the contents were removed, the mass of the pouch was measured, and the adsorption rate was determined from the rate of change.
: Less than 2% ○: More than 2% and less than 5% ×: More than 5%

[Contaminant sealability (1)]
An anti-inflammatory analgesic solution (Ammelz: manufactured by Kobayashi Pharmaceutical Co., Ltd.) was applied to the seal layer surface of the laminate film prepared above with a cotton swab, and the seal surfaces were sealed after 3 minutes (seal temperature: 150 ° C., seal pressure: 0.2 MPa, Sealing time: 1 second) Sealed. The strength before and after coating was measured to determine the strength reduction rate.

[Contaminant sealability (2)]
Dissolve starch (research reagent: manufactured by ASONE) with a cotton swab on the sealing layer surface of the laminate film prepared above, and after 3 minutes, seal surfaces (sealing temperature: 150 ° C., sealing pressure: 0.4 MPa, sealing time: 1 second) Sealed. The strength before and after coating was measured to determine the strength reduction rate.
A: Less than 10% B: 10% to 20%
×: 20% or more

[Packaging machine suitability]
Each laminate film is made with a vertical pillow packaging machine (manufactured by Sanko Kikai Co., Ltd.), and a four-side sealed pouch measuring 45 mm long and 85 mm wide is created while changing the sealing temperature. The seal strength was measured.
A: 20 N / 15 mm or more B: 15-20
X: Less than 15N / 15mm

[Pinhole / Dart]
After making 5 bags of three-sided seal pouches of 75mm length x 55mm width for each laminated film, after enclosing 5 sheets of Salon Pass (manufactured by Hisamitsu Pharmaceutical Co., Ltd.), the opening (seal temperature: 150 ° C, seal pressure: 0.5 MPa, seal) Time: 1 second) Heat sealed. The sealed packaging bag was allowed to stand at 25 ° C. for 2 hours, then opened to remove the contents, and pinholes and darts (seal leakage) were inspected with a seal checker solution.
◎: No pinhole, dart ○: Pinhole, 2 darts or less ×: Pinhole, 3 darts or more

  As is clear from the above table, the packaging structures of Examples 1 to 16 of the present invention have suitable tearability and a wide sealing suitability temperature range, and can suitably suppress volatilization of the active ingredient and the like to the heat seal surface. Even when foreign matter adheres, it is excellent in suitable foreign matter sealability in which poor adhesion hardly occurs. Further, pinholes and darts were hardly generated and the packaging machine suitability was excellent.

Claims (11)

A packaging structure for packaging a patch with a packaging material,
The layer serving as the innermost surface in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin resin, and has a resin layer containing a cyclic polyolefin resin on the outside of the heat-sealable resin layer, A heat-sealable resin layer and a resin layer containing a cyclic polyolefin resin are directly laminated ,
The patch packaging structure, wherein the heat-sealable resin layer containing the olefin resin has a thickness of 2 to 8 μm .   The packaging structure according to claim 1, wherein a resin layer containing an olefin resin and a resin layer containing a cyclic polyolefin resin are sequentially laminated on an outer layer of the resin layer containing the cyclic polyolefin resin.   The packaging structure of a patch according to claim 1 or 2, wherein the content of the cyclic polyolefin resin in the resin component contained in the resin layer containing the cyclic polyolefin resin is 80% by mass or more.   4. The content of the cyclic polyolefin resin having a glass transition temperature of 100 ° C. or lower in the cyclic polyolefin resin contained in the resin layer containing the cyclic polyolefin resin is 40% by mass or more. Packaging structure of the described patch.   The heat-sealable resin layer containing the olefin resin contains 80% by mass or more of linear low-density polyethylene in the resin component contained in the resin layer containing the olefin resin. Packaging structure of the patch according to crab. The packaging structure of a patch according to claim 5, wherein the density of the linear low-density polyethylene is 0.905 g / cm ^{3 to} 0.925 g / cm ³ .
The packaging structure of a patch according to any one of claims 1 to 6, wherein the resin layer containing the cyclic polyolefin-based resin has a thickness of 3 to 12 µm. The packaging material is a laminated film having a heat-sealable resin layer containing an olefin resin and a resin layer containing the cyclic polyolefin-based resin as a sealant film, and the heat-sealable resin layer of the sealant film is the other The packaging structure of a patch according to any one of claims 1 to 7, which is a packaging material comprising a laminate film in which a base material is bonded to the outer layer. 9. The laminated film according to claim 8, wherein the laminated film has a resin layer containing an olefin resin and a resin layer containing a cyclic polyolefin resin on the outer side of the resin layer containing the cyclic polyolefin resin. Packaging structure of the described patch. The packaging structure of a patch according to claim 8 or 9, wherein the total thickness of the laminated film is 10 to 100 µm.   The packaging structure of a patch according to any one of claims 1 to 10, wherein the content of the cyclic polyolefin resin in the heat-sealable resin layer containing the olefin resin is 10% by mass or less.