KR102503474B1 - Growth promoter for livestock - Google Patents

Abstract

The disclosed content relates to a growth promoter for livestock, which increases the amount of calcium absorbed into the body of livestock and increases the bioavailability of calcium, further alleviating the stress of livestock and enhancing the appetite of livestock.
The disclosed information provides a growth promoter for livestock containing inorganic calcium, a peptide source, a yeast hydrolysate, an excipient, and a dispersing agent as an example.

Description

Growth promoter for livestock {Growth promoter for livestock}

The disclosed content is utilized when breeding livestock such as cattle, pigs, chickens, horses, ducks, and the like, and relates to a growth promoter for livestock that can supplement feed for livestock.

Unless otherwise indicated herein, material described in this section is not prior art to the claims in this application, and it is not admitted that the material described in this section is prior art.

Calcium is an essential mineral nutrient involved in many biological processes, including cell signaling, nerve conduction, enzyme activity regulation, muscle contraction and skeletal tissue (Carafoli, 2002, Miller & McBean, 2001, Zhou & Yang, 2013).

Calcium has a wide range of functions in the body. Functions of life maintenance and skeletal metabolism Calcium is present in bones, teeth, and bodily fluids including blood, and performs major life support and skeletal metabolism functions such as heartbeat, nerve transmission, blood coagulation, and control of material movement through cell membranes. To maintain these functions, it is essential to maintain the homeostasis of calcium concentration in cells and blood. The difference in concentration is so great that when the calcium concentration in the blood is 1, the intracellular calcium concentration must be maintained at 1/10,000. Only when such a large concentration difference is maintained can calcium transmit information normally to cells throughout the body. When calcium is insufficient, the balance between the concentration difference between cells and blood is also broken, and cells that do not receive normal information transmission cause various diseases. (Conigrave & Brown, 2008)

As an example of such a calcium-containing livestock feed, Korean Patent Publication No. 2001-0008883 (published on February 5, 2001) discloses that a shell extract diluted to an appropriate concentration is 100% based on 100% by weight of a known formulated feed composition. ~ 250 parts by weight are added, and the shell extract contains 1,620-2,200 mg of calcium, 25-314 mg of sodium, 12-165 mg of potassium, 978-82 mg of magnesium, 06-034 mg of iron, 001-006 ppm of copper, and 015- of zinc per 100 g of the extract sample. Disclosed is a formulated feed composition for livestock, characterized in that it contains 066 ppm, 175 to 02 ppm of manganese, and 750 to 920 mg of phosphorus.

In addition, as another example, Korean Patent Registration No. 10-1328671 (registered on November 6, 2013) is a primary crushing step of preparing shell powder by collecting, washing, and primary crushing shells, obtained in the primary crushing step A first firing step of firstly firing the shell powder, a second grinding step of secondarily grinding the firstly fired shell powder obtained in the first firing step to have an average particle diameter within the range of 1 to 140, the above 2 The shell powder obtained in the differential crushing step is mixed with macsumsuk powder, but 1 to 5% by weight of shell powder, 30 to 62% by weight of calcined macsumsuk powder, 20 to 40% by weight of non-calcined macsumsuk powder, and 10 to 20% by weight of zeolite powder %, 5 to 20% by weight of bentonite and 2 to 5% by weight of illite powder to prepare a powder mixture, and mix the above powder mixture with water, but the mixing ratio of the powder mixture: water is 1: 1 to 1 by weight A mixing step of obtaining a slurry by mixing in a ratio within the range of 3 and a granulation step of drying the slurry obtained in the mixing step by a hot air drying method in a granulator to form granules Characterized in that it comprises a granulation step Disclosed is a method for producing a calcium-enhanced livestock feed additive including macsumsuk and shells.

The formulated feed composition for livestock and livestock feed additives containing calcium may increase the calcium content in the livestock feed. At this time, the calcium added is in the form of inorganic calcium, and it is difficult to absorb all calcium into the body of livestock, and there is a problem that the bioavailability of calcium is low.

Patent Document 1: Korean Patent Publication No. 2001-0008883 (published on February 5, 2001) Patent Document 2: Korean Patent Registration No. 10-1328671 (registered on November 6, 2013)

The disclosed invention is to provide a growth promoter for livestock that increases the amount of calcium absorbed into the body of livestock and increases the bioavailability of calcium, further alleviating the stress of livestock and enhancing the appetite of livestock.

In addition, it is not limited to the technical problems as described above, and it is obvious that other technical problems may be derived from the following description.

The disclosed information provides a growth promoter for livestock containing inorganic calcium, a peptide source, a yeast hydrolysate, an excipient, and a dispersing agent as an example.

According to the characteristics of the disclosed contents, it is a growth promoter for livestock containing 12 parts by weight of inorganic calcium, 25 parts by weight of a peptide source, 14.002 parts by weight of a yeast hydrolysate, 67.998 parts by weight of an excipient, and 2 parts by weight of a dispersant.

According to the growth promoter for livestock according to one embodiment of the disclosed information, there is an advantage of increasing the amount of calcium absorbed into the body of livestock and increasing the bioavailability of calcium. In addition, it has the advantage of alleviating the stress of livestock and enhancing the appetite of livestock.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the description of the claims.

1 is a graph showing the test results according to Example 2.
Figure 2 is a graph showing the test results according to Example 2.
Figure 3 is a graph showing the test results according to Example 3.

Hereinafter, with reference to the accompanying drawings, look at the configuration and operation effects of preferred embodiments of the disclosed contents. For reference, in the drawings below, each component is omitted or schematically illustrated for convenience and clarity, and the size of each component does not reflect the actual size. In addition, like reference numerals refer to like components throughout the specification, and reference numerals for like components in individual drawings will be omitted.

A growth promoter for livestock according to an embodiment of the present disclosure includes inorganic calcium, a peptide source, a yeast hydrolysate, an excipient, and a dispersing agent. The disclosed growth promoter for livestock includes 1.2 to 24 parts by weight of the inorganic calcium, 2.5 to 50 parts by weight of the peptide source, and 1.4 to 28 parts by weight of the yeast hydrolysate. In particular, it is preferable to contain 12 parts by weight of the inorganic calcium, 25 parts by weight of the peptide source, 7.001 parts by weight of the yeast hydrolysate, 67.998 parts by weight of the excipient, and 2 parts by weight of the dispersant.

The inorganic calcium is inorganic calcium generally used in livestock feed, and is inorganic calcium having basicity. The inorganic calcium serves to provide calcium ions that bind to the peptide source during the manufacturing process of the disclosed growth promoter for livestock. As such inorganic calcium, calcium oxide, calcium hydroxide, and calcium carbonate are preferable. The disclosed growth promoter for livestock includes 1.2 to 24 parts by weight of the inorganic calcium. If the amount of inorganic calcium is less than 1.2 parts by weight, the growth promoter cannot provide calcium ions. Conversely, if the amount of inorganic calcium exceeds 24 parts by weight, the amount of inorganic calcium is wasted because the amount is much larger than that of the peptide source that binds to calcium ions. Considering this point, the inorganic calcium preferably contains 12 parts by weight.

The peptide source refers to a protein that has been appropriately decomposed by an enzyme and is composed of more amino acids and peptides, which are smaller units than proteins. Substances that can be the source of the peptides may include bacterial culture medium by-products, yeast extracts, soybean enzymatically decomposed proteins, and the like. Here, the bacterial culture medium by-product enables the disclosed growth promoter for livestock to have price competitiveness. And the yeast extract allows the disclosed growth promoter for livestock to alleviate the stress of livestock due to the peptides and amino acids constituting it. Therefore, it is preferable to use the bacterial culture medium by-product and the yeast extract as the source of the peptide. In particular, considering the price competitiveness and stress relieving effect of the disclosed growth promoter for livestock, 25 parts by weight of the peptide source is preferably composed of 20 parts by weight of the bacterial culture medium by-product and 5 parts by weight of the yeast extract.

The peptide source binds calcium ions derived from the inorganic calcium during the manufacturing process of the disclosed growth promoter for livestock so that calcium can be effectively absorbed into the body of livestock.

The disclosed growth promoter for livestock contains 2.5 to 50 parts by weight of the peptide source. If the peptide source is less than 2.5 parts by weight, it cannot properly bind to calcium ions derived from the inorganic calcium. Conversely, if the peptide source exceeds 50 parts by weight, the amount of the peptide source compared to calcium ions is large, and the peptide source may be wasted.

The yeast hydrolyzate is a product obtained by hydrolyzing yeast, and is prepared by mixing dry yeast, process water, and enzyme. The yeast hydrolyzate contains 1.4 to 28 parts by weight. If the yeast hydrolyzate is less than 1.4 parts by weight, the growth promoter for livestock is insignificant in the effect of enhancing the appetite.

The yeast hydrolyzate is prepared by mixing 1 to 4 parts by weight of dry yeast, 3 to 24 parts by weight of the process water, and 0.001 to 0.005 parts by weight of the enzyme. In particular, it is preferable to have a ratio of 1 part by weight of the dry yeast, 6 parts by weight of the process water, and 0.001 part by weight of the enzyme. The dry yeast refers to drying the yeast so that the yeast does not rot, The disclosed growth promoter for livestock corrects nutritional deficiencies in livestock and promotes metabolism.

The enzyme is a proteolytic enzyme, and any enzyme capable of decomposing a protein may be used. Representatively, bromelain or papain may be used. The bromelain refers to a proteolytic enzyme extracted from pineapple stems, and the papain refers to a proteolytic enzyme extracted from papaya.

The excipient serves to provide proteins, amino acids, or peptides that can additionally bind to calcium ions derived from the inorganic calcium. Such materials include soybean meal, fish meal, meat and bone meal, tallow meal, and rapeseed meal. Among them, it is preferable to use soybean meal so that the disclosed growth promoter for livestock can have price competitiveness.

The dispersant allows the disclosed growth promoter for livestock to have growth promoting and immunity enhancing effects of livestock. A material that can be used as a dispersing agent includes gelite, and gelite is a material belonging to natural minerals.

The disclosed growth promoter for livestock may further include an adjuvant in addition to the above composition, examples of which include preservatives, stabilizers, and the like. These adjuvants serve to prevent the disclosed growth promoter for livestock from decaying or deteriorating.

Hereinafter, the test process and results for examining the effect of feeding the disclosed growth promoter for livestock in the feed for finishing pigs on productivity and broiler performance are shown.

And hereinafter, the disclosed growth promoter for livestock is referred to as CALMORIN ^® .

[Example 1]

This [Example 1] shows the test process and results for examining the effect of feeding CALMORIN ^® in pig feed on productivity.

1-1. Test animals and test design

Tertiary hybrid [(Landrace × Yorkshire) × Duroc] 90 fattening pigs were announced, and the weight at the start of the test was 52.96 ± 1.70 kg, and the feeding test was conducted for 56 days. The trial design was 1) CON; basal diet, 2) TRT1; Basal diet + 0.05% CALMORIN ^® , 3) TRT2; Basal diet + 0.10% CALMORIN ^® 3 treatments, 6 repetitions per treatment, 5 heads per repetition were completely randomized.

1-2. Test feed and breeding management

The breeding test was conducted at Dankook University's test farm located in Gongju-si. As the test feed, corn-soybean meal-based feed formulated according to NRC (2012) requirements was used. The test feed was prepared using a blender located in the test farm, and was allowed to eat freely, and water was adjusted so that it could be freely consumed using an automatic waterer.

1-3. Investigation item and method

Daily weight gain, feed intake, and feed efficiency were measured for each individual at the start of the test, the 4th week and the end (8 weeks) of the test. Feed intake was calculated by subtracting the remaining amount from feed intake at the time of weight measurement, and feed efficiency was calculated by dividing daily weight gain by feed intake.

1-4. Test result

All data were tested by processing linear and quadratic statistics to confirm the effect of the added level of CALMORIN ^® using the General Linear Model procedure of SAS (2013) (P < 0.05).

<Table 1> below shows the test results according to [Example 1].

<Table 1>

Overall, in terms of feed efficiency, the CALMORIN ^® 0.1% feeding group showed an improvement of 0.012.

[Example 2]

This [Example 2] shows the test process and results to determine the effect of CALMORIN ^® feeding on broiler chicken production performance.

1-1. Test animals and test design

60,400 broilers were announced, and the average weight at the start of the test was 1.635 kg, and the feeding test was conducted for 30 days. The test design was 1) Control (20,000 subjects); Basic feed 2) Treatment 1 (20,000 animals); Basic feed + 0.1% CALMORIN ^® added 3) Treatment 2 (20,000 counts); Basic diet + 0.1% CALMORIN ^® was set to be added.

1-2. Test feed and breeding management

The feeding test was conducted at a farm located in Gimcheon, Gyeongsangbuk-do. Among the test feeds, the basic feed refers to the administration of antibiotic ampicillin drinking water together with Koryo Industrial feed.

1-3. Investigation item and method

The average broiler weight was measured and the feed conversion rate (FCR) was measured.

1-4. Test result

<Table 2> below shows the test results according to [Example 2]. The test results for the average shipping weight were graphically illustrated in FIG. 1, and the test results for the feed conversion rate were graphically illustrated in FIG. 2.

<Table 2>

Compared to the control group, the experimental group showed good results in mean shipping weight and improved FCR by 0.02~0.04.

[Example 3]

This [Example 3] shows another test process and results to determine the effect of CALMORIN ^® feeding on broiler chicken production performance.

1-1. Test animals and test design

46,400 broilers were announced, and the average weight at the start of the test was 743.5g, and the breeding test was conducted for 12 days before broiler shipment. The test design was 1) control group (24,000 subjects); Basic diet 2) Experimental group (22,400 animals); Basic diet + 0.1% CALMORIN ^® was set to be added.

1-2. Test feed and breeding management

The feeding test was conducted at a farm located in Gyeongsangnam-do. Among the test feeds, the basic feed refers to the administration of antibiotic ampicillin drinking water together with Koryo Industrial feed.

1-3. Investigation item and method

Broiler daily weight load cell and feed conversion rate (FCR) were measured.

1-4. Test result

<Table 3> below shows the test results according to [Example 3]. When <Table 3> is graphically schematized, it is as shown in FIG.

<Table 3>

The experimental group showed an improvement of 83.27g in weight gain and 10.6% in FCR compared to the control group.

Although the preferred embodiments of the present invention have been described with reference to the accompanying drawings, the embodiments described in this specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention and represent all the technical ideas of the present invention. Since it is not, it should be understood that there may be various equivalents and modifications that can replace them at the time of this application. Therefore, the embodiments described above should be understood as illustrative and not restrictive in all respects, and the scope of the present invention is indicated by the claims to be described later rather than the detailed description, and the meaning and scope of the claims and their All changes or modified forms derived from equivalent concepts should be construed as being included in the scope of the present invention.

Claims (8)

12 parts by weight of inorganic calcium, 25 parts by weight of a peptide source, 7.001 parts by weight of yeast hydrolysate, 67.998 parts by weight of an excipient, and 2 parts by weight of a dispersant,
The inorganic calcium is any one of calcium oxide, calcium hydroxide, and calcium carbonate,
The peptide source consists of 20 parts by weight of bacterial culture medium by-products and 5 parts by weight of yeast extract,
The yeast hydrolyzate is composed of 1 part by weight of dry yeast, 6 parts by weight of process water and 0.001 part by weight of enzyme,
The enzyme is any one of bromelain and papain,
The excipient is soybean meal,
The dispersant is gelite,
Growth promoter for livestock, characterized in that it further comprises any one or more adjuvants selected from the group consisting of preservatives and stabilizers.




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