KR102492057B1 - 골 형태형성 단백질 6(ｂｍｐ6)의 억제제를 사용한 질병의 치료 방법 - Google Patents

골 형태형성 단백질 6(ｂｍｐ6)의 억제제를 사용한 질병의 치료 방법 Download PDF

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KR102492057B1
KR102492057B1 KR1020197001175A KR20197001175A KR102492057B1 KR 102492057 B1 KR102492057 B1 KR 102492057B1 KR 1020197001175 A KR1020197001175 A KR 1020197001175A KR 20197001175 A KR20197001175 A KR 20197001175A KR 102492057 B1 KR102492057 B1 KR 102492057B1
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seq
bmp6
nos
antibody
sequences
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KR20190018690A (ko
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펭 콩
윌리엄 디트리히
나탈리 조지
동 리우
아셔 스캐치터
아디티 소니
징 조우
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노파르티스 아게
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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KR1020197001175A 2016-06-15 2017-06-13 골 형태형성 단백질 6(ｂｍｐ6)의 억제제를 사용한 질병의 치료 방법 Active KR102492057B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350257P 2016-06-15 2016-06-15
US62/350,257 2016-06-15
PCT/IB2017/053507 WO2017216724A1 (en) 2016-06-15 2017-06-13 Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6)

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KR20190018690A KR20190018690A (ko) 2019-02-25
KR102492057B1 true KR102492057B1 (ko) 2023-01-26

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US (1) US11434269B2 (https=)
EP (1) EP3471759A1 (https=)
JP (1) JP7231411B2 (https=)
KR (1) KR102492057B1 (https=)
CN (1) CN110381988A (https=)
AU (1) AU2017283787B2 (https=)
CA (1) CA3027651A1 (https=)
IL (1) IL263664A (https=)
WO (1) WO2017216724A1 (https=)

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GB2550114A (en) 2016-05-03 2017-11-15 Kymab Ltd Methods, regimens, combinations & antagonists
WO2019173283A1 (en) 2018-03-05 2019-09-12 Marquette University Method and apparatus for non-invasive hemoglobin level prediction
CA3045370A1 (en) * 2018-06-08 2019-12-08 Pfizer Inc. Methods of treating metabolic disease
GB201815629D0 (en) * 2018-09-25 2018-11-07 Kymab Ltd Antagonists
WO2020257587A1 (en) * 2019-06-19 2020-12-24 Cornell University Methods of promoting erythropoiesis and overcoming erythropoitein resistance in patients
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
CN114075287B (zh) * 2020-08-18 2023-07-21 湖南远泰生物技术有限公司 人源化bcma抗体和bcma-car-t细胞
KR20240062222A (ko) 2022-10-28 2024-05-09 안재남 IoT 동작 기기 제어용 디지털 통신 시스템 및 그 구동방법
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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