KR102484787B9 - 미소구체 제조 시스템 - Google Patents

미소구체 제조 시스템

Info

Publication number
KR102484787B9
KR102484787B9 KR1020210067548A KR20210067548A KR102484787B9 KR 102484787 B9 KR102484787 B9 KR 102484787B9 KR 1020210067548 A KR1020210067548 A KR 1020210067548A KR 20210067548 A KR20210067548 A KR 20210067548A KR 102484787 B9 KR102484787 B9 KR 102484787B9
Authority
KR
South Korea
Prior art keywords
microsphere manufacturing
microsphere
manufacturing
Prior art date
Application number
KR1020210067548A
Other languages
English (en)
Other versions
KR102484787B1 (ko
KR20220076269A (ko
Inventor
김주희
전찬희
Original Assignee
(주)인벤티지랩
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)인벤티지랩 filed Critical (주)인벤티지랩
Priority to KR1020210067548A priority Critical patent/KR102484787B1/ko
Publication of KR20220076269A publication Critical patent/KR20220076269A/ko
Application granted granted Critical
Publication of KR102484787B1 publication Critical patent/KR102484787B1/ko
Publication of KR102484787B9 publication Critical patent/KR102484787B9/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/812—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more alternative mixing receptacles, e.g. mixing in one receptacle and dispensing from another receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Colloid Chemistry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
KR1020210067548A 2020-11-30 2021-05-26 미소구체 제조 시스템 KR102484787B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020210067548A KR102484787B1 (ko) 2020-11-30 2021-05-26 미소구체 제조 시스템

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020200164614A KR102259589B1 (ko) 2020-11-30 2020-11-30 미소구체 제조 시스템 및 미소구체 제조 방법
KR1020210067548A KR102484787B1 (ko) 2020-11-30 2021-05-26 미소구체 제조 시스템

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020200164614A Division KR102259589B1 (ko) 2020-11-30 2020-11-30 미소구체 제조 시스템 및 미소구체 제조 방법

Publications (3)

Publication Number Publication Date
KR20220076269A KR20220076269A (ko) 2022-06-08
KR102484787B1 KR102484787B1 (ko) 2023-01-05
KR102484787B9 true KR102484787B9 (ko) 2024-04-08

Family

ID=76372804

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020200164614A KR102259589B1 (ko) 2020-11-30 2020-11-30 미소구체 제조 시스템 및 미소구체 제조 방법
KR1020210067548A KR102484787B1 (ko) 2020-11-30 2021-05-26 미소구체 제조 시스템

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020200164614A KR102259589B1 (ko) 2020-11-30 2020-11-30 미소구체 제조 시스템 및 미소구체 제조 방법

Country Status (6)

Country Link
US (1) US20240016742A1 (ko)
EP (1) EP4252900A4 (ko)
JP (1) JP2023551321A (ko)
KR (2) KR102259589B1 (ko)
CN (1) CN117202892A (ko)
WO (1) WO2022114450A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102259589B1 (ko) * 2020-11-30 2021-06-02 (주)인벤티지랩 미소구체 제조 시스템 및 미소구체 제조 방법
KR102386163B1 (ko) * 2021-12-03 2022-04-14 (주)인벤티지랩 류프로라이드를 포함하는 마이크로 입자 및 이의 제조 방법
KR102431191B1 (ko) * 2021-12-22 2022-08-11 (주)인벤티지랩 미소구체 제조 장치 및 미소구체 제조 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT729353E (pt) * 1993-11-19 2002-07-31 Alkermes Inc Preparacao de microparticulas biodegradaveis contendo um agente biologicamente activo
US6291013B1 (en) * 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
CA2497723A1 (en) 2002-09-11 2004-03-25 Tanabe Seiyaku Co., Ltd. Method for preparation of microspheres and apparatus therefor
JP5377862B2 (ja) * 2007-01-26 2013-12-25 三洋化成工業株式会社 単分散微粒子の製造法
KR20130047232A (ko) * 2011-10-31 2013-05-08 재단법인 전라남도생물산업진흥재단 초임계유체를 이용한 서방형 약물 함유 미립자의 제조방법 및 이를 이용한 의료용 스텐트의 제조방법
US9439864B2 (en) * 2014-07-07 2016-09-13 Antriabio, Inc. Solvent extraction from biodegradable microparticles
GB201622024D0 (en) * 2016-11-14 2017-02-08 Inventage Lab Inc Apparatus and method for large scale production of monodisperse, microsheric and biodegradable polymer-based drug delivery
KR102142026B1 (ko) * 2017-05-31 2020-08-06 주식회사 대웅제약 방출제어가 용이한 서방성 약물 미립자의 제조방법
KR102259589B1 (ko) * 2020-11-30 2021-06-02 (주)인벤티지랩 미소구체 제조 시스템 및 미소구체 제조 방법

Also Published As

Publication number Publication date
JP2023551321A (ja) 2023-12-07
KR102484787B1 (ko) 2023-01-05
KR20220076269A (ko) 2022-06-08
EP4252900A1 (en) 2023-10-04
CN117202892A (zh) 2023-12-08
US20240016742A1 (en) 2024-01-18
KR102259589B1 (ko) 2021-06-02
KR102259589B9 (ko) 2021-08-23
WO2022114450A1 (ko) 2022-06-02
EP4252900A4 (en) 2024-06-05

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E701 Decision to grant or registration of patent right
GRNT Written decision to grant
Z072 Maintenance of patent after cancellation proceedings: certified copy of decision transmitted [new post grant opposition system as of 20170301]
Z131 Decision taken on request for patent cancellation [new post grant opposition system as of 20170301]