KR102479886B1 - 재조합 당단백질 및 이의 용도 - Google Patents

재조합 당단백질 및 이의 용도 Download PDF

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KR102479886B1
KR102479886B1 KR1020217027690A KR20217027690A KR102479886B1 KR 102479886 B1 KR102479886 B1 KR 102479886B1 KR 1020217027690 A KR1020217027690 A KR 1020217027690A KR 20217027690 A KR20217027690 A KR 20217027690A KR 102479886 B1 KR102479886 B1 KR 102479886B1
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protein
galactosidase
oligosaccharides
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KR20210111880A (ko
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카렌 리
크리스토퍼 황
크리스틴 데마리아
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젠자임 코포레이션
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70592CD52
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12P21/005Glycopeptides, glycoproteins
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    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01022Alpha-galactosidase (3.2.1.22)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C12N2510/00Genetically modified cells

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KR1020217027690A 2013-10-23 2014-10-22 재조합 당단백질 및 이의 용도 Active KR102479886B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361894879P 2013-10-23 2013-10-23
US61/894,879 2013-10-23
US201361901942P 2013-11-08 2013-11-08
US61/901,942 2013-11-08
PCT/US2014/061789 WO2015061464A2 (en) 2013-10-23 2014-10-22 Recombinant glycoproteins and uses thereof
KR1020167013333A KR102298080B1 (ko) 2013-10-23 2014-10-22 재조합 당단백질 및 이의 용도

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KR1020167013333A Division KR102298080B1 (ko) 2013-10-23 2014-10-22 재조합 당단백질 및 이의 용도

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KR20210111880A KR20210111880A (ko) 2021-09-13
KR102479886B1 true KR102479886B1 (ko) 2022-12-20

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KR1020167013333A Active KR102298080B1 (ko) 2013-10-23 2014-10-22 재조합 당단백질 및 이의 용도

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US (2) US11208644B2 (https=)
EP (2) EP3060660B1 (https=)
JP (2) JP6837334B2 (https=)
KR (2) KR102479886B1 (https=)
CN (3) CN105916984A (https=)
AU (2) AU2014340152A1 (https=)
BR (1) BR112016008086A2 (https=)
CA (1) CA2927852A1 (https=)
CL (1) CL2016000961A1 (https=)
CR (1) CR20160225A (https=)
DK (1) DK3060660T3 (https=)
DO (1) DOP2016000079A (https=)
EA (1) EA034515B1 (https=)
ES (1) ES2882562T3 (https=)
HR (1) HRP20211197T1 (https=)
HU (1) HUE055236T2 (https=)
IL (2) IL245255B (https=)
LT (1) LT3060660T (https=)
MX (1) MX392532B (https=)
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NZ (1) NZ720384A (https=)
PE (1) PE20160723A1 (https=)
PH (1) PH12016500708B1 (https=)
PL (1) PL3060660T3 (https=)
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RS (1) RS62171B1 (https=)
SG (2) SG11201602932WA (https=)
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TN (1) TN2016000140A1 (https=)
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CA3039673A1 (en) 2016-10-20 2018-04-26 Sangamo Therapeutics, Inc. Methods and compositions for the treatment of fabry disease
TW201829770A (zh) * 2017-01-10 2018-08-16 美商阿米庫斯醫療股份有限公司 用於治療fabry氏病之重組α-半乳糖苷酶A
WO2025092951A1 (en) * 2023-11-03 2025-05-08 Shanghai Vitalgen Biopharma Co., Ltd. Recombinant adeno-associated viral vectors for treating fabry disease

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WO2015061464A3 (en) 2015-09-03
PH12016500708A1 (en) 2016-05-30
JP7296327B2 (ja) 2023-06-22
RS62171B1 (sr) 2021-08-31
LT3060660T (lt) 2021-07-26
HRP20211197T1 (hr) 2021-11-12
TWI793159B (zh) 2023-02-21
SI3060660T1 (sl) 2021-09-30
KR20160066550A (ko) 2016-06-10
DK3060660T3 (da) 2021-09-13
MY197247A (en) 2023-06-08
US20160264953A1 (en) 2016-09-15
CN105916984A (zh) 2016-08-31
CL2016000961A1 (es) 2017-02-03
UA119857C2 (uk) 2019-08-27
ES2882562T3 (es) 2021-12-02
PT3060660T (pt) 2021-08-06
JP6837334B2 (ja) 2021-03-03
IL272609B (en) 2022-03-01
KR102298080B1 (ko) 2021-09-06
UY35794A (es) 2015-05-29
EA034515B1 (ru) 2020-02-14
CN114606217A (zh) 2022-06-10
EA201690826A1 (ru) 2016-08-31
IL245255B (en) 2020-02-27
SG10201803366PA (en) 2018-05-30
NZ720384A (en) 2022-04-29
TWI642782B (zh) 2018-12-01
JP2016538840A (ja) 2016-12-15
EP3778884A1 (en) 2021-02-17
DOP2016000079A (es) 2016-05-30
HUE055236T2 (hu) 2021-11-29
JP2020089379A (ja) 2020-06-11
CR20160225A (es) 2016-06-24
AU2014340152A1 (en) 2016-06-09
US11208644B2 (en) 2021-12-28
PH12016500708B1 (en) 2023-03-01
IL245255A0 (en) 2016-06-30
MX2016005321A (es) 2017-01-05
AU2020294173A1 (en) 2021-02-11
BR112016008086A2 (pt) 2017-10-03
PE20160723A1 (es) 2016-08-01
MX392532B (es) 2025-03-24
TN2016000140A1 (en) 2017-10-06
TW201610163A (zh) 2016-03-16
WO2015061464A2 (en) 2015-04-30
US20220064617A1 (en) 2022-03-03
MY178632A (en) 2020-10-19
TW202332774A (zh) 2023-08-16
CA2927852A1 (en) 2015-04-30
KR20210111880A (ko) 2021-09-13
PL3060660T3 (pl) 2021-12-06
TW201900873A (zh) 2019-01-01
CN112852784A (zh) 2021-05-28
SG11201602932WA (en) 2016-05-30
EP3060660B1 (en) 2021-06-23
EP3060660A2 (en) 2016-08-31
IL272609A (en) 2020-03-31

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