KR102455518B1 - ＲＯＳ1 저해제로서 치환된 4,5,6,7-테트라히드로피라졸로[1,5-ａ]피리미딘 유도체 및 2,3-디히드로-1Ｈ-이미다조[1,2-ｂ]피라졸 유도체 - Google Patents
ＲＯＳ1 저해제로서 치환된 4,5,6,7-테트라히드로피라졸로[1,5-ａ]피리미딘 유도체 및 2,3-디히드로-1Ｈ-이미다조[1,2-ｂ]피라졸 유도체 Download PDFInfo
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- KR102455518B1 KR102455518B1 KR1020167027337A KR20167027337A KR102455518B1 KR 102455518 B1 KR102455518 B1 KR 102455518B1 KR 1020167027337 A KR1020167027337 A KR 1020167027337A KR 20167027337 A KR20167027337 A KR 20167027337A KR 102455518 B1 KR102455518 B1 KR 102455518B1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
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| EP14161959 | 2014-03-27 | ||
| EP14161959.3 | 2014-03-27 | ||
| PCT/EP2015/056501 WO2015144801A1 (en) | 2014-03-27 | 2015-03-26 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND 2,3-DIHYDRO-1H-IMIDAZO[1,2-b]PYRAZOLE DERIVATIVES AS ROS1 INHIBITORS |
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| KR20160137566A KR20160137566A (ko) | 2016-11-30 |
| KR102455518B1 true KR102455518B1 (ko) | 2022-10-14 |
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| CN106580982B (zh) * | 2016-11-26 | 2017-09-22 | 王玉美 | 一种治疗药物流产后子宫出血的药物 |
| CN106866536A (zh) * | 2017-04-12 | 2017-06-20 | 中国农业大学 | 一种制备4‑卤代‑5‑氨基吡唑的方法 |
| JP7069295B2 (ja) * | 2017-08-17 | 2022-05-17 | エックスダブリューファルマ リミテッド | 活性酸素種スカベンジャー誘導体の調製および使用 |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
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| CN111087398A (zh) * | 2019-12-24 | 2020-05-01 | 上海万巷制药有限公司 | 一种制备拉罗替尼中间体的清洁工艺 |
| EP4105206A4 (en) | 2020-01-13 | 2024-08-14 | Aptabio Therapeutics Inc. | NOVEL PYRAZOLE DERIVATIVE |
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| CN113416140B (zh) * | 2021-06-03 | 2023-01-13 | 万华化学集团股份有限公司 | 一种制备2-甲基戊二胺的方法 |
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| WO2009108838A1 (en) | 2008-02-29 | 2009-09-03 | Wyeth | Bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-a]pyrimidines, methods for preparation and uses thereof |
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| JP2017508777A (ja) | 2017-03-30 |
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| CA2941206A1 (en) | 2015-10-01 |
| EP3126366A1 (en) | 2017-02-08 |
| CN106132967A (zh) | 2016-11-16 |
| CN106132967B (zh) | 2019-05-28 |
| US20170173014A1 (en) | 2017-06-22 |
| JP6527167B2 (ja) | 2019-06-05 |
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