KR102442455B1 - Food composition for improving respiratory diseases using natural products and method for producing same - Google Patents

Abstract

The present invention relates to a food composition for improving respiratory diseases using natural products including bellflower, jujube, quince, peppermint, dried medicinal herbaceous root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, cinnamon root, cinnamon branch, and ginger root. It relates to a manufacturing method thereof.

Description

Food composition for improving respiratory diseases using natural products and a method for producing the same {Food composition for improving respiratory diseases using natural products and method for producing same}

The present invention relates to a food composition for improving respiratory diseases using natural products including bellflower, jujube, quince, peppermint, dried medicinal herbaceous root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, cinnamon root, cinnamon branch and ginger root. It relates to a manufacturing method thereof.

As we enter the modern era, fine dust is becoming an issue day by day.

For humans who breathe air, clean air is an essential element to sustain life. However, yellow dust caused by desertification of the arid regions of northern China and Mongolia contains various harmful bacteria and substances such as heavy metals, and is confirmed as a serious health hazard. In Korea, based on the concentration of yellow dust in the air, the yellow dust crisis warning is divided into four levels of concern, caution, and seriousness, and efforts are being made to secure safety by announcing action guidelines for the public.

On the other hand, with the increase of human economic activity in the modern era, the use of fossil fuels has rapidly increased, and as a result, carbon compounds, sulfates, nitrates, and harmful heavy metal compounds generated by combustion are also rapidly increasing. These fine combustion products have a higher content of heavy metals than yellow sand and are known to be more harmful than yellow sand because they float in the air for a long time.

Fine dust refers to fine dust floating in the air, and is called PM10 for particles with a particle diameter of 10 μm or less, PM5 for particles with a particle diameter of 5 μm or less, PM2.5 for particles with a particle diameter of 2.5 μm or less, and PM1 for particles with a particle diameter of 1 μm or less. Particulate matter with a particle diameter of 2.5 μm or less is referred to as ultra-fine dust.

The fine dust and ultrafine dust float in the air for a long time due to their minute size and move long distances. In particular, it is becoming more of a problem in traffic dense areas, industrial complex areas, subway and underground shopping malls, large-scale living complexes, various construction sites, large amusement parks, and department stores. In Korea, according to the amount of fine dust in the air, it is classified as good, normal, slightly bad, bad, and very bad.

The fine dust and ultrafine dust can penetrate into the human body as it is through the respiratory system or through the skin, which threatens health by causing respiratory system-related diseases such as airway stimulation, decreased lung function, worsening of asthma, and occurrence of chronic bronchitis. there was.

In order to solve the above problems, Republic of Korea Patent No. 10-1286463 discloses a composition for preventing or treating respiratory diseases containing a cheongung extract, which contains cheongung, a lower alcohol having 1 to 4 carbon atoms or 10 thereof. Asthma, chronic obstructive pulmonary disease, allergic rhinitis, cough, characterized in that the crude extract extracted with ~95% alcohol aqueous solution is soluble and purified with a solvent selected from the group consisting of ethyl acetate, dichloromethane and butanol as an active ingredient It relates to a composition for preventing or treating respiratory diseases selected from the group consisting of , sputum, bronchitis, sore throat, tonsillitis and laryngitis.

In addition, Korean Patent Publication No. 10-1943475 discloses a food composition for the prevention and improvement of respiratory diseases, which includes 9 packs of mountain bellflower, washed and dried mountain deodeok, washed and dried lichen root and stalk root. was mixed in a weight ratio of 2:1:1:1 to 4:1:1:1, and 10 times the amount (w/v) of distilled water was added to the mixture and extracted at 90 to 130° C. for 4 to 24 hours, followed by a filter paper It relates to a food composition for enhancing respiratory function and preventing or improving respiratory diseases, characterized in that the extract is prepared by collecting and drying under reduced pressure by repeating the process of recovering the supernatant with a furnace three times.

However, since the prior patents have insignificant effects of enhancing respiratory function and preventing or improving respiratory diseases, the need for a method of combining and extracting a composition to have a better effect is increasing.

Patent Document 0001) Republic of Korea Patent Publication No. 10-1286463 (published on July 16, 2013). "Composition for the prevention or treatment of respiratory diseases containing chrysanthemum extract" Republic of Korea Patent Publication No. 10-1943475 (2019.01.29. Announcement), "Food composition for prevention and improvement of respiratory diseases"

In order to solve the above problems, the present invention provides a respiratory disease including bellflower, jujube, quince, mint top, dried medicinal buckwheat root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, chrysanthemum root, cinnamon branch and ginger root. An object of the present invention is to provide a food composition that can improve

In order to achieve the above object, the present invention is a mixed herbal medicine by mixing bellflower, jujube, quince, peppermint, dried medicinal buckwheat, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, cinnamon root, cinnamon branch, and ginger root. A mixed herbal medicine manufacturing step (S10) to prepare a; A mixed herbal medicine extract preparation step (S20) of extracting the mixed herbal medicines of the step (S10) in a vacuum to prepare a mixed herbal medicine extract; A mixed herbal medicine concentrate preparation step (S30) of concentrating the mixed herbal medicine extract of the step (S20) to prepare a mixed herbal medicine concentrate; Respiratory disease improvement using natural products, characterized in that it comprises; It provides a method for preparing a food composition for use.

In addition, in the step (S10), the mixed herbal material is 10 to 20% by weight of the bellflower, 10 to 20% by weight of the jujube, 3 to 7% by weight of the quince, 3 to 7% by weight of the peppermint upper part, and the dried 3 to 7% by weight of the yakmomil above, 3 to 7% by weight of the loquat leaf, 3 to 7% by weight of the ginseng root, 3 to 7% by weight of the Rehmannia root, 1 to 5% by weight of the rhizome root, 3 to 7% by weight of the radish root, 3 to 7% by weight of the cinnamon branch, and 3 to 7% by weight of the ginger root.

In addition, in the step (S20), water, an alcohol having 1 to 4 carbon atoms, methanol, ethanol, butanol or propanol, any one or more extraction solvents are added, and the mixture is extracted in a vacuum state.

In addition, the syrup preparation step (S40) is characterized in that it further comprises a process of fermenting the kimchi lactic acid bacteria fermented powder contained therein.

In addition, the present invention provides a food composition for improving respiratory diseases using a natural product, which is manufactured through the above method, and has an effect of improving respiratory diseases.

The food composition for improving respiratory diseases using a natural product according to the present invention has the effect of strengthening respiratory function and preventing or improving respiratory diseases.

1 is a flowchart showing a method of manufacturing a food composition for improving respiratory diseases using a natural product according to the present invention.
Figure 2 is a flowchart showing a method of manufacturing a food composition for improving respiratory diseases using a natural product according to another embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following detailed description of the present invention is an embodiment in which the present invention may be practiced, and reference is made to the accompanying drawings shown by way of example of the embodiment. These embodiments are described in sufficient detail to enable those skilled in the art to practice the present invention. It should be understood that various embodiments of the present invention are different but need not be mutually exclusive. For example, certain shapes, structures, and characteristics described herein may be implemented in other embodiments without departing from the spirit and scope of the invention in relation to one embodiment. In addition, it should be understood that the position or arrangement of individual components in each described embodiment may be changed without departing from the spirit and scope of the present invention.

Accordingly, the detailed description set forth below is not intended to be taken in a limiting sense, and the scope of the present invention, if properly described, is limited only by the appended claims, along with all scopes equivalent to those claimed by the claims. Like reference numerals in the drawings refer to the same or similar functions throughout the various aspects.

The terms used in the present invention have been selected as currently widely used general terms as possible while considering the functions in the present invention, but these may vary depending on the intention or precedent of a person skilled in the art, the emergence of new technology, and the like. In addition, in a specific case, there is a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the corresponding invention. Therefore, the term used in the present invention should be defined based on the meaning of the term and the overall content of the present invention, rather than the name of a simple term.

In the present invention, when a part “includes” a certain component, it means that other components may be further included, rather than excluding other components, unless otherwise stated.

As shown in FIGS. 1 to 2, the method for manufacturing a food composition for improving respiratory disease using a natural product according to the present invention is bellflower, jujube, quince, mint top, dried medicinal herbaceous root, loquat leaf, ginseng root, and rehmannia root. , a mixed herbal preparation step (S10) of preparing a mixed herbal material by mixing cheongung root, chamomile root, cinnamon branch, and ginger root; A mixed herbal medicine extract preparation step (S20) of extracting the mixed herbal medicines of the step (S10) in a vacuum to prepare a mixed herbal medicine extract; A mixed herbal medicine concentrate preparation step (S30) of concentrating the mixed herbal medicine extract of the step (S20) to prepare a mixed herbal medicine concentrate; Mixing the mixed herbal medicine concentrate of the step (S30) with the oligosaccharide, DL-menthol, propolis and kimchi lactic acid bacteria fermented powder to prepare liquid tea, soft sea extract, syrup preparation step (S40); include

The bellflower ( Platycodon ) grandiflorum ) is a perennial plant of the bellflower family, also called Gilgyeong, Dorat, Gilgyeongchae, Baekyak, Plantain, and Sandraji. The bellflower grows in mountains and fields. The roots of the bellflower are thick and the stems grow straight, and white juice comes out when cut. The height is 40-100 cm. The leaves of the bellflower are alternate phyllotaxis and are long egg-shaped or broad lanceolate, with saw teeth on the edge, and no petiole. The tip of the leaf of the bellflower is sharp and the bottom is wide. The front side of the leaf of the bellflower is green and the back side is grayish-blue, and has no hairs and is 4-7 cm long and 1.5-4 cm wide. The flower of the bellflower is white or purple in July-August and blooms upwards in a bell-shaped shape with a spreading tip, 4-5 cm in diameter, and divided into 5 parts. In the bellflower, the calyx is also divided into 5, and the branch is lanceolate. The stamens of the bellflower are 5, the pistil is 1, the ovary is 5 rooms, and the stigma head is divided into 5 pieces. The fruit of the bellflower is a capsule, egg-shaped, and ripens with a calyx piece attached. Propagation of the bellflower is good with seeds. The bellflower roots are collected in spring and autumn and eaten raw or as greens. The main component of the bellflower is saponin. Gilgyeong (桔梗), a herbal medicine, is the root that has been peeled or dried as it is. Those with white flowers are called white bellflower (for. albiflorum), those with double flowers are called for. duplex, and those with white flowers are called white bellflower (for. leucanthum). The flower language is eternal love. It is distributed in Korea, Japan and China.

The jujube ( Ziziphus ) jujuba var . inermis ) refers to the fruit of the date tree. The jujube is also called red jujube because its color is red. The pulp of the jujube contains mainly sugar, and also contains mucilage, magmaic acid, tartaric acid, and the like. The seeds of the jujube contain betulin, beturic acid, and fat, and are widely used as diuretic tonic, sedative, and nourishing in oriental medicine. In addition, the jujube is widely used for food and is an essential fruit for preparing food for ceremonial occasions. The jujubes are made by putting the fruit as it is on a defrost or a feast, or making it into processed foods such as joran and jujube vinegar, and it is often used as a garnish for rice cakes or food.

The quince is a plant in the family Pearaceae, Chaenomeles . lagenaria ( Loisel .) Koidz . ) and dried fruits of quince ( C. sinensis Koeh . ). Myeongja trees are planted in various parts of the country, and quince trees are planted in the south central part of our country. The quince is harvested in autumn, put in boiling water, boiled for 5 minutes, dried in the sun until the skin is wrinkled, then split and dried completely. The taste of the quince is sour and the nature is warm. The quince acts on liver cirrhosis (肝经), nasal passages (脾经), menopause (肺经). The quince removes wind and wet sand, improves gastric function, and soothes cramps. The quince also exhibits anti-inflammatory action. The quince is used for joint pain, beriberi, stomach ache, vomiting, diarrhea, and cramps in the gastrocnemius muscle, and there is no strength in the legs. Take 6~10g per day in the form of soup, pills, and powders.

The upper part of the peppermint refers to the above-ground part of the peppermint ( Mentha piperascens ). The mint is a dicotyledonous plant, a perennial plant of the Lamiaceae family, and is also called late-night sagebrush (夜息香), Beonhachae, Indancho (仁丹草), and Gubakha (歐薄荷). The mint grows in moist fields. The mint is 60-100 cm in height. The stem of the peppermint has a rectangular cross section, hairs on the surface, and the leaves face each other as single leaves with a stalk, and the edges are serrated. There are oil glands on the leaf surface of the mint to secrete oil, and most of the essential oil is stored in these glands. The mint hangs in the shape of small, pale purple flowers in the upper leaf axils of the stem from summer to autumn. The mint has 4 stamens, and one pistil has two ends, and the ovary has 4 chambers. The mint flower is mainly bloomed in the morning, and the pistil is fertilized in 3-4 days after the flower blooms, and the stamens are fertilized in 2-3 days. The mint seeds are egg-shaped, light brown, light and small, and germinate well at alternate temperature of 20 → 30 → 15℃. The main component of peppermint oil is menthol, and this menthol is used medicinally as a liniment, analgesic, stimulant, gastric and anthelmintic, or as a refreshing agent or flavoring agent in toothpaste, jam, candy, cosmetics, and cigarettes.

The dry yakmomil above ground is yakmomil ( Houttuynia ) cordata ) refers to the above-ground part. The Yakmomil is a perennial herb of the dicotyledonous plant Capsicumaceae. The yakmomil is also called eoseongcho. The Yakmomil grows in a shady forest. Yakmomil has long, thin and white underground stems. The stem of the yakmomil stands upright and is 20-50 cm in height, has several vertical lines, and smells. The leaves of the yakmomil are alternate phyllotaxis, 3-8 cm long, have a sharp tip, have a flat edge, and a stipule is attached to the lower part of the petiole. The flowers of the Yakmomil bloom in May to June, and a large number of them run in a dendritic inflorescence at the end of a short peduncle from the tip of the stem. The involucre is divided into 4 and hangs in a cross shape under the inflorescence and looks like a petal, and the split piece is oval or long oval with a length of 1.5-2cm, and is white. The length of the inflorescence is 1-3cm, the flower has no petals and sepals, has 3 stamens and 1 pistil, has 3 styles, and the ovary is uppermost and has 3 threads. The fruits of the Yakmomil are capsules, and the seeds are light brown. The yakmomil is used as a diuretic and anthelmintic in the plant before flowering, and is applied when the leaves are crushed and bitten by boils and poisonous insects. In folk medicine, it is used for swelling, suppuration, and hemorrhoids, and in oriental medicine, the plant is used for gonorrhea, enteritis, urinary tract infection, pneumonia, and bronchitis. The leaves are similar to those of buckwheat and are medicinal plants, so it is called Yakmomil. Distributed in Korea (Ulleungdo, Anmyeondo, Geoje Island), Japan, China, Himalayas, Java

The loquat leaves are loquat trees ( Eriobotrya japonica ( Thunb . ) Lindl . ) refers to the leaves of The loquat tree is an evergreen small tall tree planted for ornamental purposes. The trunk of the loquat tree is 3-5 m in height, but sometimes reaches 10 m. The loquat has many brown hairs on young branches. There is no petiole or about 1 cm. The leaves of the loquat tree are alternate phyllotaxis, narrow obovate or long oval, with sparsely toothed teeth on the edge, the front side of the leaf is hairless and shiny, and the back side has brown hairs and is leathery. The flowers of the loquat are white and fragrant, blooming in panicles from the tips of branches in October-December. The fruit of the loquat tree is pomegranate, has a wide oval shape, ripens yellow, and has a good taste. The loquat tree is planted in the southern regions of Korea. Distributed in Japan and China.

The ginseng root is a small stem of the Adenophora family . triphylla var . japonica Hara ) or a medicinal herb made from the root of a common plant. Sasam, along with ginseng (人參), hyeonsam (玄蔘), dansam (丹參), and gosam (苦參) are called five ginseng (five ginseng) because they all have different forms but the same treatment. The name Sasam (沙參) is given because it is white and grows well in sandy soil. There is a lot of white juice in the root, so it was also called onionae (羊婆?) by two people. This medicine has a unique aroma and is mucinous when chewed, has a slightly sweet taste and slightly cold in nature. , phlegm, seawater, asthma, etc. It is used for symptoms such as dry mouth, dry throat, and constipation due to lack of gastric juice. As pharmacological action, expectorant action, antibacterial action, hemolytic action, and strong heart action have been reported. The shape is fusiform or long conical, curved, and sometimes has branched roots. There is a rhizome with crooked transverse folds at the top. The root is light and easy to break, and the cut side is milky white and has many gaps.

The Rehmannia root is Rehmannia . glutinosa ( GAERTNER ) LIBOSCHITZ ) refers to the root. Rehmannia is a herbaceous perennial plant belonging to the Hyeonsamaceae family. It is a Chinese plant, has short hairs, and has thick roots and spreads out sideways. It is used as a medicine in oriental medicine. It's called a sleepover situation. The near-saeng leaf (根生葉) is a genus (叢生), long oval, and has dull serrations on the edge as a blunt, sharp-bottomed leaf. Flowers bloom in June and July and run in a raceme at the end of the stalk. Rehmannia root is used as a medicinal herb in oriental medicine. It is called raw jihwang, dried and steamed with alcohol, and steamed with alcohol. The active ingredient contains catalpol and mannit, and the water-soluble part includes mannitol, stachyose, and glucose. The extract of Saengjihwang promotes blood coagulation and increases the contractility of the heart muscle against a weakened heart. In addition, it has a diuretic effect and antipyretic effect. It suppresses experimentally induced hyperglycemia and lowers normal rabbit blood sugar. Sukjihwang has a nourishing and tonic effect, lowering blood sugar, and it is recognized that it has a cardiac and diuretic effect. Saengjihwang is weak and has a bitter and sweet taste, Geonjihwang is cold and sweet, and Sukjihwang is mild and sweet. Saengjihwang is a febrile disease. It is used when thirsty, the tongue appears red, and symptoms of constipation and restlessness are present. It is used in combination with other drugs for the purpose of hemostasis in hematemesis, nasal bleeding, and hemorrhoidal bleeding. In addition, it is used for diabetes or acute and chronic rheumatism. Geon-hwang is used when there is bleeding during pregnancy by controlling the woman's menstruation. Sukjihwang is effective as an anemia treatment, and is also effective in reproductive function decline, chronic nephritis, hypertension, diabetes, and nervous breakdown. In addition, it is often used to relieve asthma due to weakness of the kidneys. Saengjihwang should not be used for pregnant women or those with diarrhea, and Geonjihwangdo is also not used for people with diarrhea. Sukjihwang is not used for people who have poor digestion and often have poor digestion. Yanghyeoljihwangtang (凉血地黃湯) used for hemostasis and Yukmijihwangtang (六味地黃湯) for promoting reproductive function and secretion of the sex glands are widely used in oriental medicine. In folklore, it is sometimes applied to the affected area by pounding Saengjihwang when it is sprained. This is because Saengjihwang heals by removing pain and heat.

The Cnidium root is Cnidium officinale ) root. The chrysanthemum is native to China and is cultivated as a medicinal plant. The cheongung is 30-60 cm in height, is hollow, and has somewhat branched branches. The leaves of the cheongung are alternate phyllotaxis, 2 times 3 leaf pinnate compound leaves, and the forked pieces are egg-shaped lancets and have somewhat deep serrations. The root leaf and the lower leaf of the cheongung have a long petiole, and the lower part becomes a sheath and surrounds the stem. The flowers of the celestial palace are bloomed in August-September and are white and form a double-shaped inflorescence. The flower petals are 5, curled inward, 5 stamens and 1 pistil. Guns and rifles are 5-6 each, and they are line-shaped. The fruit is opened but not matured. Between the nodes in the ground, it is formed like a mass with a length of 5 to 10 cm and a diameter of 3 to 5 cm, and has a strong fragrance. The cheongung is effective in sedation, analgesia, and tonic, and is used to treat headache, anemia, and gynecological diseases. The cheongung is used as a pill (丸劑) or a powder (散劑), the rhizomes are harvested in September-November, the leaves and stems are removed, dried in the sun, and then 3-6g is decoctioned.

The root of the Angelica root is Angelica . gigas NAKAI ) refers to the roots. The chamomile perennial is a biennial or perennial herb that grows in relatively moist soil. The fat root of the champignon contains milky juice and gives off a strong scent. The stem of the Angelica keiskei is thick and straight and grows to a height of about 2 m and slightly branched. The large leaves of the chamomile are alternately positioned at each node and split into three branches once or twice. The split leaf pieces of the Angelica keiskei are divided into 3 to 5 branches again to a medium depth. A sharp sawtooth is formed on the edge of the leaf of the sagebrush. The base of the petiole spreads wide and completely encloses the stem. Innumerable small flowers running at the ends of the stems and branches of the Angelica keiskei are clustered together to form an umbrella shape. The purple flower of the genus Angelica has 5 petals, and the diameter is about 3mm. The chamangwi is distributed nationwide and grows in valleys or moist soils in mountainous areas.

The cinnamon branch is an evergreen arboreal tree belonging to the camphoraceae (天竹桂, Cinnamomum ). japonicum SIEB . ) refers to the branches of It is mainly grown in southern China, southern Japan, Vietnam, Cambodia and Thailand. The active ingredient is about 1% of the volatile essential oil component, and among them, Phellandrene, Eugenol, Methyleugenol, and the like are contained. The taste of the medicine is spicy and sweet, and the weakness is recessive. Its efficacy activates the function of the gastrointestinal tract, so it is widely used for digestive disorders due to a full digestive system or abdominal pain and diarrhea caused by a full stomach. In addition, it causes a quick reaction to vomiting caused by a full stomach. In addition, it is widely applied to neuralgia and joint diseases, which stop the quadriplegia and pain caused by wind suppuration, and the back and knees are cold and sore.

The ginger root is ginger ( Zingiber officinale ) root. The ginger is a monocotyledonous plant of the order Gingeraceae and is used for food and medicinal purposes. The ginger is also called Saeang Saeyang. The ginger is native to Southeast Asia and is grown as a vegetable. The rhizome of the ginger grows sideways, is fleshy, has a lumpy shape, is yellow, and has a pungent taste and a fragrant smell. At each node of the rhizome of the ginger, a fake stem made of a sheath stands upright and reaches a height of 30-50 cm, and the leaves are arranged in two rows at the top. The leaves of the ginger are alternate phyllotaxis, line-shaped lancets, narrow at both ends, and a long sheath at the bottom. The ginger does not flower in Korea, but in the tropics, a 20-25 cm long peduncle wrapped in a leaf sheath appears in August, and a flower bud hangs at the end. The ginger flower comes out between the bracts and has a length of 4 to 7.6 cm. The calyx of the ginger is in the shape of a short tube, and the end of the corolla is split into three, and the split piece has a sharp end. There is one stamen of the ginger and the anther is yellow. The ovary of the ginger is lower (下位), and the style is thin like a thread.

In the mixed herbal medicine manufacturing step (S10), bellflower, jujube, quince, mint top, dried medicinal buckwheat top, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, cinnamon root, cinnamon branch, and ginger root are mixed to prepare a mixed herbal material do.

In the step (S10), the mixed herbal material is 10 to 20% by weight of the bellflower, 10 to 20% by weight of the jujube, 3 to 7% by weight of the quince, 3 to 7% by weight of the peppermint upper part, and the dried medicinal buckwheat 3 to 7% by weight of the above-ground part, 3 to 7% by weight of the loquat leaves, 3 to 7% by weight of the ginseng root, 3 to 7% by weight of the rehmannia root, 1 to 5% by weight of the rhizome rhizome, the above Angelica root may be included in 3 to 7% by weight, the cinnamon branch is 3 to 7% by weight, and the ginger root is 3 to 7% by weight. Purified water may be included in the remaining amount.

Most preferably, the mixed herbal material is 15% by weight of the bellflower, 15% by weight of the jujube, 5% by weight of the quince, 5% by weight of the peppermint upper part, 5% by weight of the dried medicinal buckwheat above, 5% by weight of the loquat leaf Weight %, the ginseng root is 5% by weight, the rehmannia root is 5% by weight, the chrysanthemum rhizome is 3% by weight, the rhododendron root is 5% by weight, the cinnamon branch is 5% by weight, the ginger root is 5% by weight Inclusion in % would be appropriate. Purified water may be included in the remaining amount.

It would be appropriate to wash and mix the herbal materials mixed in the mixed herbal material manufacturing step (S10).

Next, the mixed herbal medicine extract preparation step (S20) of preparing the mixed herbal medicine extract by extracting the mixed herbal medicines of the step (S10) in a vacuum is performed.

In the step (S20), 2000 to 4000 cc of mixed herbal ingredients consisting of bellflower, jujube, quince, mint peppermint, dried herbaceous root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, Angelica root, cinnamon branch, and ginger root An extraction solvent is added, and the mixed herbal medicine is extracted in a vacuum at a temperature of 110 to 130° C. for 200 to 270 minutes.

As the extraction solvent, any one or more solvents selected from water, alcohol having 1 to 4 carbon atoms, methanol, ethanol, butanol, or propanol may be selected and used by mixing. Preferably, it is appropriate to mix water and ethanol in a weight ratio of 7:3.

If the extraction solvent in the step (S20) is less than 2000cc, the amount of the extract is too small, and if it exceeds 4000cc, the concentration of the extract is too low, so there is a problem in that the final result effect is lowered.

It is appropriate to maintain the temperature of 110 to 130 ℃ in the step (S20), but if the temperature is less than 110 ℃, there is a problem that the extraction of the mixed herbal medicine does not occur properly because the temperature is too low, and when the temperature exceeds 130 ℃ There is a problem in that it is difficult to accurately obtain the effect of the final product because the properties of the mixed herbal medicine are changed because it is too high.

In addition, the extraction time of the step (S20) is appropriate for 200 to 270 minutes, and if the extraction time is less than 200 minutes, the extraction does not proceed and the concentration of the extract is low, the effect of the final result is reduced, and the extraction time is 270 minutes. If it is exceeded, it is economically inefficient because most of the extraction has already been done.

Next, a mixed herbal medicine concentrate preparation step (S30) of concentrating the mixed herbal medicine extract of step (S20) to prepare a mixed herbal medicine concentrate is performed.

It is appropriate that the step (S30) proceeds with a low-temperature concentration method.

In the step (S30), 2000cc to 4000cc of mixed herbal medicine extract is made into 500cc to 1000cc of mixed herbal medicine concentrate by a low temperature concentration method.

Agitation may be performed in the process of concentrating the mixed herbal medicine extract in the step (S30).

The low-temperature concentration method of the step (S30) may be performed at a temperature of 50 to 80° C. in a vacuum through a vacuum low-temperature concentrator in order to concentrate the components affected by heat or the components oxidized by air.

Next, a syrup preparation step (S40) of preparing a syrup by mixing the mixed herbal medicine concentrate of the step (S30), oligosaccharide, dl-menthol, propolis, and kimchi lactic acid bacteria fermented powder is performed.

In the syrup preparation step (S40), the mixed herbal medicine concentrate is mixed with oligosaccharide, dl-menthol, propolis, kimchi lactic acid bacteria fermented powder, etc. to prepare liquid tea, soft sea extract or syrup.

At this time, in liquid tea, soft sea extract, and syrup, the bellflower extract is 10 to 20% by weight, the jujube extract is 10 to 20% by weight, the quince extract is 3 to 7% by weight, and the mint extract is 3 to 7% by weight , 3 to 7% by weight of the dried medicinal mulberry extract, 3 to 7% by weight of the loquat leaf extract, 3 to 7% by weight of the ginseng root extract, 3 to 7% by weight of the rehmannia root extract, and the Chunkyung rhizome The extract is 1 to 5% by weight, the Angelica root extract is 3 to 7% by weight, the cinnamon branch extract is 3 to 7% by weight, the ginger root extract is 3 to 7% by weight, the oligosaccharide is 10 to 20% by weight , The DL-menthol is 3 to 7% by weight, the propolis is 1 to 3% by weight, the kimchi lactic acid bacteria fermented powder may be included in 0.1 to 1% by weight.

The oligosaccharide is a sugar polymer including a small number of monosaccharides (2-10). In general, the oligosaccharide exists in the form of a glycan, and these are found in the form of being linked to an amino acid side branch of a fat or protein, and generally found in two forms: an N-linked or an O-linked oligosaccharide. N-linked oligosaccharides are found attached to asparagine through the beta bond of the amine nitrogen on the side branch. 5) O-linked oligosaccharides are usually attached to the side alcohol group of a threonine or serine group. Oligosaccharides have many functions, including cell recognition and cell binding.

The dl-menthol ( DL-Mentol ) is a flavoring agent belonging to aliphatic higher alcohols and is used in beverages, ice cream, gum, and the like. The dl-menthol is a colorless columnar or needle-shaped crystal or white crystalline powder, with a peculiar and refreshing aroma, and is a flavoring agent having a slightly bitter taste at first and then a refreshing taste. The chemical formula of dl-menthol is C10H20O. Insoluble in water, soluble in organic solvents and hydrochloric acid. The dl-menthol is sublimable and non-rotating. The dl-menthol has a freezing point of 27 to 28 °C, a melting point of 32 to 38 °C, a boiling point of 103 to 105 °C, and a refractive index n(20, D) of 1.4615. The allowable daily intake (ADI) of dl-menthol is 0.0-0.2 mg/kg. When administered orally to rats, the LD50 (LD50) is 3.18g/kg. The dl-menthol is used in beverages, ice cream, and gum, and should not be used for purposes other than flavoring. Since the dl-menthol is volatilized, it is stored in a sealed container in a cool and dark place.

The propolis ( propolis ) refers to a product made by collecting tree secretions and mixing them with bees' saliva (saliva) and beeswax. The flopolis contains various organic substances, minerals, and flavonoids as an oily component, is useful in inhibiting various cancers, and has excellent antibacterial and antioxidant effects. The etymology of propolis is derived from Greek, pro means 'in front' and polis means 'city'. Therefore, propolis, a combination of the two origins, means to protect the entire city in front of the city, and it also means to protect the safety of the city (village) and prevent disease. In addition, it has the meaning of protecting the life of bees in the hive. That is, the bees attach propolis to the entrance and inner surfaces of the honeycomb to prevent the invasion of bacteria from the outside. The propolis is composed of 50-55% of resin, 25-35% of beeswax, 10% of oily components such as essential oil, 5% of pollen, 5% of various organic and inorganic substances, etc., and contains 30 volatile components. More than one type of compound is isolated, and the main components are flavonoids (flavones, flavones, etc.). Flavonoids have an inhibitory action against bacteria and viruses.

The kimchi lactic acid bacteria fermented powder is a powder that is fermented and pulverized by fermenting kimchi with lactic acid bacteria, and the kimchi lactic acid bacteria used to obtain the kimchi lactic acid bacteria fermented powder are kimchi lactic acid bacteria from Leuconostoc, kimchi lactic acid bacteria from Lactobacillus genus, wei. It may be any one selected from kimchi lactic acid bacteria of the genus Weissella and mixed lactic acid bacteria thereof.

The leuconostoc (Leuconostoc) genus Kimchi lactic acid bacteria is leuconostoc citreum (Leuconostoc citreum), leuconostoc lactis (Leuconostoc lactis), leuconostoc megentroid subspie. Dextranicum (Leuconostoc mesenteroides subsp. dextranicum), Leuconostoc mesenteroid subsp. Mesenteroid (Leuconostoc mesenteroides subsp. Mesenteroides), Leuconostoc argentinum, Leuconostoc carnosum, Leuconostoc gellidum, Leuconostoc kimchii , Leuconostoc due to (Leuconostoc inhae), Leuconostoc gasicomitatum (Leuconostoc gasicomitatum), and may be any one selected from the group consisting of a lactic acid mixture thereof.

The Lactobacillus genus Kimchi lactic acid bacteria are Lactobacillus brevis, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus plantarum, Lactobacillus plantarum (Lactobacillus plantarum) Kimchi Eye (Lactobacillus kimchii), Lactobacillus paraplantarum (Lactobacillus paraplantarum), Lactobacillus curbatus subscipi. Curvatus (Lactobacillus curvatus subsp. curvatus), Lactobacillus Sakei subsippi. It may be any one selected from the group consisting of sake (Lactobacillus sakei subsp. sakei) and mixed lactic acid bacteria thereof.

The Weissella genus kimchi lactic acid bacteria are Weissella koreensi, Weissella hanii, Weissella kimchii, Weissella soli, Weissella confusa (Weissella koreensi). Weissella confusa) and a mixture thereof may be any one selected from the group consisting of lactic acid bacteria.

The present invention is not limited to the type of kimchi lactic acid bacteria, and various types of lactic acid bacteria capable of obtaining fermented kimchi lactic acid bacteria powder by fermenting kimchi will all be available as kimchi lactic acid bacteria. In other words, it refers to all of the various lactic acid bacteria that are naturally introduced and cultured in the process of salting and storing kimchi at a low temperature.

The syrup preparation step (S40) may further include a process of mixing the mixed herbal medicine concentrate with oligosaccharides, DL-menthol, propolis, and fermented kimchi lactic acid bacteria powder, and fermenting through the fermented kimchi lactic acid bacteria powder contained therein.

The fermentation period in the syrup preparation step (S40) may be performed at a low temperature of 1 to 10° C. for 1 to 3 days.

In the syrup preparation step (S40), the mixed herbal medicine concentrate oligosaccharide, dl-menthol, propolis, kimchi lactic acid bacteria fermented powder, etc. are mixed to prepare liquid tea, soft sea extract, syrup, etc., and then use the liquid tea, soft sea extract, syrup, etc. can be packaged and provided to users. The user may mix it with water and drink it as tea.

According to another embodiment of the present invention, a food composition for improving respiratory diseases using a natural product may be prepared in the form of a pill.

The method for producing a food composition for improving respiratory disease using a natural product according to another embodiment of the present invention is bellflower, jujube, quince, peppermint upper part, dried medicinal herbaceous plant part, loquat leaf, ginseng root, rehmannia root, cheongung root, chunganggwi root , a mixed herbal preparation step (S10) of preparing a mixed herbal medicine by mixing cinnamon branch and ginger root; A mixed herbal medicine extract preparation step (S20) of extracting the mixed herbal medicines of the step (S10) in a vacuum to prepare a mixed herbal medicine extract; A mixed herbal medicine concentrate preparation step (S30) of concentrating the mixed herbal medicine extract of the step (S20) to prepare a mixed herbal medicine concentrate; A mixed powder manufacturing step (S40) of mixing and drying bellflower, jujube, quince, mint top, dried medicinal buckwheat root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, champignon root, cinnamon branch and ginger root to make a mixed powder (S40); and a granule, powder, and pill preparation step (S50) of mixing the mixed herbal medicine concentrate of the step (S30) and the mixed powder of the step (S40) into granules, powders, and pills.

In the mixed herbal material manufacturing step (S10), bellflower, jujube, quince, mint top, dried medicinal buckwheat top, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, chrysanthemum root, cinnamon branch and ginger root are mixed to prepare a mixed herbal medicine do.

In the step (S10), the mixed herbal material is 10 to 20% by weight of the bellflower, 10 to 20% by weight of the jujube, 3 to 7% by weight of the quince, 3 to 7% by weight of the peppermint upper part, and the dried medicinal buckwheat 3 to 7% by weight of the above-ground part, 3 to 7% by weight of the loquat leaves, 3 to 7% by weight of the ginseng root, 3 to 7% by weight of the rehmannia root, 1 to 5% by weight of the rhizome rhizome, the above Angelica root may be included in 3 to 7% by weight, the cinnamon branch is 3 to 7% by weight, and the ginger root is 3 to 7% by weight. Purified water may be included in the remaining amount.

Most preferably, the mixed herbal material is 15% by weight of the bellflower, 15% by weight of the jujube, 5% by weight of the quince, 5% by weight of the peppermint upper part, 5% by weight of the dried medicinal buckwheat above, 5% by weight of the loquat leaf Weight %, the ginseng root is 5% by weight, the rehmannia root is 5% by weight, the chrysanthemum rhizome is 3% by weight, the rhododendron root is 5% by weight, the cinnamon branch is 5% by weight, the ginger root is 5% by weight Inclusion in % would be appropriate. Purified water may be included in the remaining amount.

It would be appropriate to wash and mix the herbal materials mixed in the mixed herbal material manufacturing step (S10).

Next, the mixed herbal medicine extract preparation step (S20) of preparing the mixed herbal medicine extract by extracting the mixed herbal medicines of the step (S10) in a vacuum is performed.

In the step (S20), 2000 to 4000 cc of mixed herbal ingredients consisting of bellflower, jujube, quince, mint peppermint, dried herbaceous root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, Angelica root, cinnamon branch, and ginger root An extraction solvent is added, and the mixed herbal medicine is extracted in a vacuum at a temperature of 110 to 130° C. for 200 to 270 minutes.

As the extraction solvent, any one or more solvents selected from water, alcohol having 1 to 4 carbon atoms, methanol, ethanol, butanol, or propanol may be selected and used by mixing. Preferably, it is appropriate to mix water and ethanol in a weight ratio of 7:3.

If the extraction solvent in the step (S20) is less than 2000cc, the amount of the extract is too small, and if it exceeds 4000cc, the concentration of the extract is too low, so there is a problem in that the final result effect is lowered.

It is appropriate to maintain the temperature of 110 to 130 ℃ in the step (S20), but if the temperature is less than 110 ℃, there is a problem that the extraction of the mixed herbal medicine does not occur properly because the temperature is too low, and when the temperature exceeds 130 ℃ There is a problem in that it is difficult to accurately obtain the effect of the final product because the properties of the mixed herbal medicine are changed because it is too high.

In addition, the extraction time of the step (S20) is appropriate for 200 to 270 minutes, and if the extraction time is less than 200 minutes, the extraction does not proceed and the concentration of the extract is low, the effect of the final result is reduced, and the extraction time is 270 minutes. If it is exceeded, it is economically inefficient because most of the extraction has already been done.

Next, a mixed herbal medicine concentrate preparation step (S30) of concentrating the mixed herbal medicine extract of step (S20) to prepare a mixed herbal medicine concentrate is performed.

It is appropriate that the step (S30) proceeds with a low-temperature concentration method.

In the step (S30), 2000cc to 4000cc of mixed herbal medicine extract is made into 500cc to 1000cc of mixed herbal medicine concentrate by a low temperature concentration method.

Agitation may be performed in the process of concentrating the mixed herbal medicine extract in the step (S30).

The low-temperature concentration method of the step (S30) may be performed at a temperature of 50 to 80° C. in a vacuum through a vacuum low-temperature concentrator in order to concentrate the components affected by heat or the components oxidized by air.

Next, a mixed herbal medicine powder to make a mixed herbal medicine powder by mixing bellflower, jujube, quince, peppermint top, dried medicinal buckwheat root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, cinnamon root, cinnamon branch and ginger root A manufacturing step (S40) is performed.

In the step (S40), as needed, the bellflower, jujube, quince, peppermint, dried medicinal buckwheat, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, chrysanthemum root, cinnamon branch, and ginger root are thoroughly washed and mixed, After drying for 9 to 11 hours at a temperature of 70 ~ 80℃ in a dryer, 200mesh of mixed herbal medicine powder is prepared.

In the step (S40), the mixed herbal medicine powder is 10 to 20% by weight of the bellflower, 10 to 20% by weight of the jujube, 3 to 7% by weight of the quince, 3 to 7% by weight of the peppermint upper part, and the drying 3 to 7% by weight of the yakmomil above, 3 to 7% by weight of the loquat leaf, 3 to 7% by weight of the ginseng root, 3 to 7% by weight of the Rehmannia root, 1 to 5% by weight of the rhizome root, The Angelica root may be included in 3 to 7% by weight, the cinnamon branch in 3 to 7% by weight, and the ginger root in 3 to 7% by weight.

Most preferably, the mixed herbal medicine powder is 15% by weight of the bellflower, 15% by weight of the jujube, 5% by weight of the quince, 5% by weight of the peppermint upper part, 5% by weight of the dried medicinal buckwheat upper part, and the loquat leaf is 5% by weight, the ginseng root is 5% by weight, the Rehmannia root is 5% by weight, the Chunkyung rhizome is 3% by weight, the Angelica root is 5% by weight, the cinnamon branch is 5% by weight, the ginger root is 5% by weight Included in weight percent would be appropriate.

If the temperature in the step (S40) is less than 70 ℃, drying proceeds slowly and there may be problems such as the generation of putrefactive bacteria. there was

Next, a pharmaceutical preparation step (S50) of preparing granules, powders, and syrups is performed by mixing the mixed herbal medicine concentrate of step (S30) and the mixed herbal medicine powder of step (S40).

In the step (S50), the mixed herbal medicine concentrate is blended with corn powder (excipient) in a weight ratio of 2: 1, then freeze-dried to prepare granules, and the granules are mixed with the mixed powder in a weight ratio of 2: 1 to 65 to 75 ° C. After drying at a temperature of 8 to 12 hours to prepare a 200 mesh powder, the powder may be mixed with glutinous rice of the same weight and purified water of 3 to 5 times to prepare a pill having a diameter of 5 to 10 mm.

A ventilator may be used in the manufacturing process of the pills, or in the absence of a ventilator, the traditional method of making by hand is also possible.

The prepared pills are preferably dried in natural air at room temperature.

Hereinafter, a food composition for improving respiratory diseases using a natural product prepared according to the manufacturing method of the present invention will be described in detail. The following Examples and Experimental Examples only illustrate the present invention, and the present invention is not limited to the following Examples.

Preparation Example 1. Preparation of extraction solvent

The extraction solvent was prepared by mixing purified water and ethanol in a 7:3 weight ratio.

Example 1. Preparation of syrup for improving respiratory diseases using natural products

A food syrup for improving respiratory diseases using the natural product of Example 1 was prepared according to the following manufacturing method.

(S10): bellflower 15% by weight, jujube 15% by weight, quince 5% by weight, mint top 5% by weight, dried medicinal buckwheat top 5% by weight, loquat leaf 5% by weight, ginseng root 5% by weight, rehmannia root 5% by weight, 3% by weight of rhizomes of chrysanthemum, 5% by weight of Angelica root, 5% by weight of cinnamon, and 5% by weight of ginger root, and the remaining amount was filled with purified water to prepare a mixed herbal medicine.

(S20): 2000 to 4000 cc of the extraction solvent of Preparation Example 1 was added to the mixed herbal medicine of step (S10), and extracted in a vacuum at a temperature of 110 to 130 ° C. for 200 to 270 minutes to obtain a mixed herbal extract.

(S30): 2000cc of the mixed herbal medicine extract of step (S20) was concentrated in a low-temperature vacuum concentrator at 70° C. to prepare a mixed herbal medicine concentrate.

(S40): The mixed herbal medicine concentrate of step (S30) and oligosaccharide, DL-menthol, propolis and kimchi lactic acid bacteria fermented powder were mixed to prepare a syrup.

Example 2. Preparation of pills for improving respiratory diseases using natural products

Pills for improving respiratory diseases using the natural product of Example 2 were prepared according to the following manufacturing method.

(S10): bellflower 15% by weight, jujube 15% by weight, quince 5% by weight, mint top 5% by weight, dried medicinal buckwheat top 5% by weight, loquat leaf 5% by weight, ginseng root 5% by weight, rehmannia root 5% by weight, 3% by weight of rhizomes of chrysanthemum, 5% by weight of Angelica root, 5% by weight of cinnamon, and 5% by weight of ginger root, and the remaining amount was filled with purified water to prepare a mixed herbal medicine.

(S20): 2000 to 4000 cc of the extraction solvent of Preparation Example 1 was added to the mixed herbal medicine of step (S10), and extracted in a vacuum at a temperature of 110 to 130 ° C. for 200 to 270 minutes to obtain a mixed herbal extract.

(S30): 2000cc of the mixed herbal medicine extract of step (S20) was concentrated in a low-temperature vacuum concentrator at 70° C. to prepare a mixed herbal medicine concentrate.

(S40): bellflower 15% by weight, jujube 15% by weight, quince 5% by weight, mint top 5% by weight, dried medicinal buckwheat top 5% by weight, loquat leaf 5% by weight, ginseng root 5% by weight, rehmannia root 5% by weight, Mix so that it contains 3% by weight of chrysanthemum rhizome, 5% by weight of Angelica root, 5% by weight of cinnamon, and 5% by weight of ginger root. powder was obtained.

(S50): After mixing the mixture concentrate of step (S30) and corn powder in a 2: 1 weight ratio, to prepare granules by freeze-drying, the granules and the powder mixture of the step (S40) are mixed in a 2: 1 weight ratio After drying for 10 hours at a temperature of 65 to 75 ℃ to prepare a 200mesh powder, 300g of the powder was further mixed with 300g of glutinous rice and 1000ml of purified water to prepare a 5 mm diameter pill.

Comparative Example 1. Preparation of a composition containing only bellflower

In order to compare with Example 1, a composition containing only bellflower was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of bellflower instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 2. Preparation of a composition containing only jujube

In order to compare with Example 1, a composition containing only jujube was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of jujube instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 3. Preparation of a composition containing only quince

In order to compare with Example 1, a composition containing only quince was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of quince instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 4. Preparation of a composition comprising only the upper peppermint part

In order to compare with Example 1, a composition including only the upper peppermint part was prepared. The same process as in Example 1 was performed, but extraction was performed by using 100% by weight of the upper peppermint part instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 5. Preparation of a composition containing only the dry yaksoyul ground part

In order to compare with Example 1 above, a composition including only the dry yakmomil above was prepared. The same process as in Example 1 was performed, but the extraction was carried out by using 100% by weight of the dried medicinal herbaceous extract instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 6. Preparation of a composition containing only loquat leaves

In order to compare with Example 1, a composition containing only loquat leaves was prepared. The same process as in Example 1 was performed, but extraction was performed using loquat leaves as 100% by weight instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 7. Preparation of a composition containing only ginseng root

In order to compare with Example 1, a composition containing only ginseng root was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of ginseng root instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 8. Preparation of a composition containing only Rehmannia root

In order to compare with Example 1, a composition containing only Rehmannia root was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of rehmannia root instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 9. Preparation of a composition containing only chrysanthemum root

In order to compare with Example 1, a composition containing only chrysanthemum roots was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of chrysanthemum root instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 10. Preparation of a composition comprising only Angelica root

In order to compare with Example 1, a composition containing only Angelica Root root was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of Angelica Root in place of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 11. Preparation of a composition comprising only cinnamon branches

In order to compare with Example 1, a composition containing only cinnamon branches was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of cinnamon eggplant instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Comparative Example 12. Preparation of a composition comprising only ginger root

In order to compare with Example 1, a composition containing only ginger root was prepared. The same process as in Example 1 was performed, but extraction was performed using 100% by weight of ginger root instead of the mixed herbal material of step (S10). For fair comparison, the rest of the manufacturing process was performed in the same manner as in Example 1.

Example 3. Preparation of a composition fermented through fermented Kimchi lactic acid bacteria powder

The same process as in Example 1 was performed, but step (S40) was performed as follows to prepare a composition fermented through the kimchi lactic acid bacteria powder of Example 2.

(S40): The mixed herbal medicine concentrate of step (S30) was mixed with oligosaccharide, DL-menthol, propolis and fermented kimchi lactic acid bacteria powder, and further aged for 1 day to prepare a syrup.

Experimental Example 1. Airway Inflammation Inhibition Test

In order to evaluate the airway inflammation inhibitory activity of the extracts prepared in Examples 1 to 3 and Comparative Examples 1 to 12, the following using the leukocyte and eosinophil increase in the lung bronchus induced when antigen is exposed to sensitized mice. was carried out by the method, and the results are shown in Table 1 below.

The tests were made according to known methods. BALB/c female mice (6 weeks old, SLC, Japan) were sensitized by intraperitoneal administration of 10 μg of a mixture of egg albumin and alum on days 0, 7 and 14. At the same time, Examples 1 to 3 and Comparative Examples 1 to 12 were fed to mice. After 8 and 10 days after the final sensitization, 0.7% egg albumin was made into an aerosol using high-pressure compressed air and sprayed for 50 minutes to induce airway inflammation. After 24 hours of inducing inflammation, the lung bronchi were washed with 1.5 ml of a phosphate buffer solution to collect the lavage solution. The number of white blood cells and eosinophils in the washing solution were counted by fractionation. The test group to be tested was orally administered 7 times on the 7th to 10th day of the final sensitization.

division density Airway Inflammation Inhibition Rate
(%) Example 1 400 mg/ml 36 800 mg/ml 73 Example 2 400 mg/ml 35 800 mg/ml 71 Example 3 400 mg/ml 42 800 mg/ml 81 Comparative Example 1 400 mg/ml 17 800 mg/ml 33 Comparative Example 2 400 mg/ml 16 800 mg/ml 32 Comparative Example 3 400 mg/ml 6 800 mg/ml 11 Comparative Example 4 400 mg/ml 17 800 mg/ml 33 Comparative Example 5 400 mg/ml 15 800 mg/ml 31 Comparative Example 6 400 mg/ml 11 800 mg/ml 21 Comparative Example 7 400 mg/ml 5 800 mg/ml 11 Comparative Example 8 400 mg/ml 12 800 mg/ml 23 Comparative Example 9 400 mg/ml 6 800 mg/ml 11 Comparative Example 10 400 mg/ml 14 800 mg/ml 26 Comparative Example 11 400 mg/ml 10 800 mg/ml 19 Comparative Example 12 400 mg/ml 7 800 mg/ml 13 positive control Rolipram 10 mg/ml 35

As a result, it was confirmed that Examples 1 to 3 exhibit a higher airway inflammation inhibition rate than Comparative Examples 1 to 12. Compared to Comparative Examples 1 to 12 in which each drug was used alone, Examples 1 to 3 in which they were mixed showed a high airway inflammation inhibition rate, and it was confirmed that unexpected effects were obtained in the process of making a pill by combining them. Accordingly, it was confirmed that the food composition for improving respiratory diseases using a natural product according to the present invention has an effect of suppressing airway inflammation.

Experimental Example 2. Airway constriction inhibition test (in vitro)

In order to evaluate the inhibitory activity of airway constriction of the extracts prepared in Examples 1 to 3 and Comparative Examples 1 to 12, it was carried out in the following manner using an extractive bronchus, and the results are shown in Table 2 below.

The tests were made according to known methods. Hartely male guinea pigs (400-450 g, SLC, Japan) were sensitized by intravenous injection of anti-ovalbumin anti-serum at a volume of 1.5 ml/kg. After 48 hours of sensitization, the guinea pigs were killed by blood loss and the bronchial tubes were removed. After removing the other tissues attached to the bronchus in the Krebs-Heseleit liquid, a ring-shaped incision was made to include 2-3 cartilages. The cartilage part of the ring was incised while preserving the bronchial muscle, and the threads were connected on both sides and then suspended in an organ bath. After stabilization for a certain period of time, 10 μg/ml of carbachol was added to induce maximum contraction. Bronchi were washed and stabilized with Krebs-Heseleit solution. After adding the extract to be tested, 2 μmol of indomethacin was added after 1 minute. After 5 minutes, 10 μg/ml of ovalbumin was added to induce contraction. The shrinkage rate was calculated by comparing the shrinkage caused by carbachol and ovalbumin. The contraction and relaxation of the bronchi was measured using a force transducer (FT4, BioPAC system) and a physiological activity measuring instrument (MP150, BioPAC system).

division density bronchoconstriction inhibition rate
(%) Example 1 0.25 mg/ml 76 0.5 mg/ml 83 Example 2 0.25 mg/ml 75 0.5 mg/ml 82 Example 3 0.25 mg/ml 82 0.5 mg/ml 86 Comparative Example 1 0.25 mg/ml 64 0.5 mg/ml 69 Comparative Example 2 0.25 mg/ml 62 0.5 mg/ml 68 Comparative Example 3 0.25 mg/ml 34 0.5 mg/ml 38 Comparative Example 4 0.25 mg/ml 58 0.5 mg/ml 62 Comparative Example 5 0.25 mg/ml 56 0.5 mg/ml 57 Comparative Example 6 0.25 mg/ml 42 0.5 mg/ml 46 Comparative Example 7 0.25 mg/ml 36 0.5 mg/ml 40 Comparative Example 8 0.25 mg/ml 43 0.5 mg/ml 47 Comparative Example 9 0.25 mg/ml 39 0.5 mg/ml 43 Comparative Example 10 0.25 mg/ml 63 0.5 mg/ml 65 Comparative Example 11 0.25 mg/ml 53 0.5 mg/ml 55 Comparative Example 12 0.25 mg/ml 37 0.5 mg/ml 41 positive control montelukast
(montelukast) 0.25 uM 24 Rolipram 0.5 uM 72

As a result, it was confirmed that Examples 1 to 3 exhibit a higher bronchial contraction inhibition rate than Comparative Examples 1 to 12. Compared to Comparative Examples 1 to 12 in which each drug was used alone, Examples 1 to 3 in which they were mixed showed a high bronchial contraction inhibition rate, and it was confirmed that an unexpected effect appeared in the process of making a pill by combining them. Accordingly, it was confirmed that the food composition for improving respiratory diseases using a natural product according to the present invention has an effect of improving asthma.

Test Example 3. Evaluation of heavy metal emission efficacy in fine dust through animal testing

For Examples 1 to 3 and Comparative Examples 1 to 12, the efficacy of heavy metal discharge in fine dust through animal testing was evaluated.

The tests were made according to known methods. Male Sprague-Dawley rats (6 weeks old, female, male, about 250 g) were collected from the central experimental animal to check whether the obtained products of Examples and Comparative Examples effectively discharge heavy metals such as cadmium, lead, and mercury contained in fine dust. It was purchased and used, and 80 animals were assigned to each group and used in this experiment. Air containing cadmium fine dust was supplied to the control group, and air containing cadmium fine dust was supplied to the first group, along with the saline solution obtained from Examples 1 to 3, and the second group was supplied with cadmium fine dust. The saline solution of Comparative Examples 1 to 12 was administered while supplying the contained air. At this time, 0.1 mg/g of the saline lysate obtained from Examples 1 to 3 and Comparative Examples 1 to 12 was orally administered with the feed per day, and after 4 weeks of administration, the animals were sacrificed and blood was collected to the degree of discharge of heavy metals. was confirmed.

After administration of heavy metals and extracts for 4 weeks, the animals were hyperanesthetized using zoletil (zoletil 50, Virbac) 2 hours after the last administration, and serum was collected for detection of cadmium in the blood and also oxidized in brain tissue and liver. Tissues were collected in order to check the tissue damage and the distribution of antioxidant enzymes.

Cadmium was quantitatively evaluated using the atomic absorption spectrophotometry-graphite furnace method inspection principle to make the atoms excited by applying high heat to the atoms, and then cadmium atoms absorb light at 228.8 nm, and the results are shown in Table 3.

sample Cadmium blood concentration (μg/L) control 6.384 Example 1 1.484 Example 2 1.492 Example 3 1.382 Comparative Example 1 3.453 Comparative Example 2 3.238 Comparative Example 3 5.213 Comparative Example 4 3.332 Comparative Example 5 3.142 Comparative Example 6 4.788 Comparative Example 7 5.261 Comparative Example 8 4.309 Comparative Example 9 5.723 Comparative Example 10 3.432 Comparative Example 11 4.521 Comparative Example 12 5.153

As a result, it was confirmed that Examples 1 to 3 showed a lower cadmium blood concentration than Comparative Examples 1 to 12. Compared to Comparative Examples 1 to 12 in which each drug was used alone, Examples 1 to 3 in which they were mixed showed a lower cadmium blood concentration, and it was confirmed that an unexpected effect appeared in the process of making a pill by combining them. Accordingly, it was confirmed that the food composition for improving respiratory diseases using a natural product according to the present invention has an effect of discharging heavy metals in fine dust.

conclusion.

Through the Experimental Examples 1 to 3, the effect of the food composition for improving respiratory diseases using a natural product according to the present invention was confirmed. The food composition for improving respiratory diseases using a natural product of the present invention is prepared by mixing bellflower, jujube, quince, mint top, dried medicinal buckwheat root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, cinnamon root, cinnamon branch, and ginger root. According to the unexpected effect that occurred, it was confirmed that it has the effect of suppressing airway inflammation, improving asthma, and discharging heavy metals in fine dust.

In other words, the food composition for improving respiratory diseases using a natural product according to the present invention can suppress airway inflammation, improve asthma, and discharge heavy metals in fine dust, so it will have an effect of improving respiratory diseases.

Accordingly, the present invention specifies that a food composition for improving respiratory diseases using natural products has been invented as a novel herbal medicine composition having an improving effect on various respiratory diseases.

Although the present invention has been described with the accompanying drawings, this is only one embodiment of various embodiments including the gist of the present invention, and is intended to be easily implemented by those of ordinary skill in the art. For the purpose, it is clear that the present invention is not limited to the embodiments described above. Accordingly, the protection scope of the present invention should be construed by the following claims, and all technical ideas within the equivalent range by changes, substitutions, substitutions, etc. within the scope not departing from the gist of the present invention are in the right of the present invention. will be included In addition, it is clarified that some components of the drawings are provided in an exaggerated or reduced form than in reality to more clearly describe the configuration.

Claims (5)

Bellflower 10 to 20% by weight, Jujube 10 to 20% by weight, quince 3 to 7% by weight, peppermint top 3 to 7% by weight, dried medicinal buckwheat 3 to 7% by weight, loquat leaves 3 to 7% by weight, ginseng root 3 to 7% by weight, 3 to 7% by weight of Rehmannia root, 1 to 5% by weight of chrysanthemum root, 3 to 7% by weight of Angelica root, 3 to 7% by weight of cinnamon branch, and 3 to 7% by weight of ginger root mixed herbal material A mixed herbal medicine manufacturing step (S10) to prepare a;
A mixed herbal extract preparation step (S20) of adding an extraction solvent to the mixed herbal medicine of the step (S10) and extracting it in a vacuum at a temperature of 110 to 130° C. to prepare a mixed herbal medicine extract;
A mixed herbal medicine concentrate preparation step (S30) of concentrating the mixed herbal medicine extract of the step (S20) to prepare a mixed herbal medicine concentrate;
Mixing the mixed herbal medicine concentrate of the step (S30) with the oligosaccharide, DL-menthol, propolis and kimchi lactic acid bacteria fermented powder to prepare liquid tea, soft sea extract, syrup preparation step (S40); A method for producing a food composition for improving respiratory diseases using a natural product, comprising:
Bellflower 10 to 20% by weight, Jujube 10 to 20% by weight, quince 3 to 7% by weight, peppermint top 3 to 7% by weight, dried medicinal buckwheat 3 to 7% by weight, loquat leaves 3 to 7% by weight, ginseng root 3 to 7% by weight, 3 to 7% by weight of Rehmannia root, 1 to 5% by weight of chrysanthemum root, 3 to 7% by weight of Angelica root, 3 to 7% by weight of cinnamon branch, and 3 to 7% by weight of ginger root mixed herbal material A mixed herbal medicine manufacturing step (S10) to prepare a;
A mixed herbal extract preparation step (S20) of adding an extraction solvent to the mixed herbal medicine of the step (S10) and extracting it in a vacuum at a temperature of 110 to 130° C. to prepare a mixed herbal medicine extract;
A mixed herbal medicine concentrate preparation step (S30) of concentrating the mixed herbal medicine extract of the step (S20) to prepare a mixed herbal medicine concentrate;
A mixed powder manufacturing step (S40) of mixing and drying bellflower, jujube, quince, mint top, dried medicinal buckwheat root, loquat leaf, ginseng root, rehmannia root, chrysanthemum root, cinnamon root, cinnamon branch and ginger root to make a mixed powder (S40) and ,
Using a natural product, characterized in that it comprises; A method for preparing a food composition for improving respiratory diseases.
delete 3. The method of claim 1 or 2,
In the step (S20), water, alcohol having 1 to 4 carbon atoms, methanol, ethanol, butanol, or propanol, any one or more extraction solvents are added, and the mixed herbal medicine is extracted in a vacuum. Respiratory disease improvement using natural products A method for preparing a food composition for use.
A food composition for improving respiratory diseases using a natural product, which is manufactured through the method of claim 1 or 2, and has an effect on improving respiratory diseases.

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