KR102386464B9 - 유도만능줄기세포-유래 중간엽 줄기세포 전구세포로부터 유래된 엑소좀을 포함하는 비알콜성 지방간염의 예방 또는 치료용 조성물 - Google Patents

유도만능줄기세포-유래 중간엽 줄기세포 전구세포로부터 유래된 엑소좀을 포함하는 비알콜성 지방간염의 예방 또는 치료용 조성물

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Publication number
KR102386464B9
KR102386464B9 KR1020200097398A KR20200097398A KR102386464B9 KR 102386464 B9 KR102386464 B9 KR 102386464B9 KR 1020200097398 A KR1020200097398 A KR 1020200097398A KR 20200097398 A KR20200097398 A KR 20200097398A KR 102386464 B9 KR102386464 B9 KR 102386464B9
Authority
KR
South Korea
Prior art keywords
derived
ipsc
protecting
composition
mesenchymal stem
Prior art date
Application number
KR1020200097398A
Other languages
English (en)
Other versions
KR20210024417A (ko
KR102386464B1 (ko
Inventor
김수
이슬기
김지민
Original Assignee
브렉소젠 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 브렉소젠 주식회사 filed Critical 브렉소젠 주식회사
Priority to PCT/KR2020/010640 priority Critical patent/WO2021033990A1/ko
Priority to EP20855301.6A priority patent/EP4019027A4/en
Priority to CN202080043654.6A priority patent/CN114025776B/zh
Priority to JP2022510957A priority patent/JP2022544698A/ja
Priority to US17/621,743 priority patent/US20220233601A1/en
Publication of KR20210024417A publication Critical patent/KR20210024417A/ko
Application granted granted Critical
Publication of KR102386464B1 publication Critical patent/KR102386464B1/ko
Publication of KR102386464B9 publication Critical patent/KR102386464B9/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020200097398A 2019-08-22 2020-08-04 유도만능줄기세포-유래 중간엽 줄기세포 전구세포로부터 유래된 엑소좀을 포함하는 비알콜성 지방간염의 예방 또는 치료용 조성물 KR102386464B1 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PCT/KR2020/010640 WO2021033990A1 (ko) 2019-08-22 2020-08-12 유도만능줄기세포-유래 중간엽 줄기세포 전구세포로부터 유래된 엑소좀을 포함하는 비알콜성 지방간염의 예방 또는 치료용 조성물
EP20855301.6A EP4019027A4 (en) 2019-08-22 2020-08-12 COMPOSITION WITH EXOSOMES DERIVED FROM MESENCHYMAL STEM CELLS PRECURSORS DERIVED FROM INDUCED PLURIPOTENTIC STEM CELLS FOR THE PREVENTION OR TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS
CN202080043654.6A CN114025776B (zh) 2019-08-22 2020-08-12 包含源自诱导多能干细胞来源间充质干细胞前体细胞的外泌体的非酒精性脂肪肝炎预防或治疗用组合物
JP2022510957A JP2022544698A (ja) 2019-08-22 2020-08-12 人工多能性幹細胞由来間葉系幹細胞前駆細胞に由来するエキソソームを含む非アルコール性脂肪性肝炎の予防又は治療用組成物
US17/621,743 US20220233601A1 (en) 2019-08-22 2020-08-12 Composition comprising exosomes derived from induced pluripotent stem cell-derived mesenchymal stem cell progenitor for prevention or treatment of non-alcoholic steatohepatitis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20190103186 2019-08-22
KR1020190103186 2019-08-22

Publications (3)

Publication Number Publication Date
KR20210024417A KR20210024417A (ko) 2021-03-05
KR102386464B1 KR102386464B1 (ko) 2022-04-18
KR102386464B9 true KR102386464B9 (ko) 2023-12-08

Family

ID=75164035

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020200097398A KR102386464B1 (ko) 2019-08-22 2020-08-04 유도만능줄기세포-유래 중간엽 줄기세포 전구세포로부터 유래된 엑소좀을 포함하는 비알콜성 지방간염의 예방 또는 치료용 조성물

Country Status (1)

Country Link
KR (1) KR102386464B1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114728024B (zh) * 2019-11-12 2024-05-14 布瑞克斯奥根株式会社 包含源自诱导多能干细胞来源间充质干细胞的前体细胞外泌体的用于预防或治疗肾脏疾病的组合物
WO2022245066A1 (ko) * 2021-05-21 2022-11-24 브렉소젠 주식회사 비알코올성 지방간질환의 진단용 마커

Also Published As

Publication number Publication date
KR20210024417A (ko) 2021-03-05
KR102386464B1 (ko) 2022-04-18

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