KR102377805B1 - 피리미딘 및 그의 변이체, 및 그의 용도 - Google Patents
피리미딘 및 그의 변이체, 및 그의 용도 Download PDFInfo
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- KR102377805B1 KR102377805B1 KR1020187029805A KR20187029805A KR102377805B1 KR 102377805 B1 KR102377805 B1 KR 102377805B1 KR 1020187029805 A KR1020187029805 A KR 1020187029805A KR 20187029805 A KR20187029805 A KR 20187029805A KR 102377805 B1 KR102377805 B1 KR 102377805B1
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Organic Chemistry (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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| US201662313334P | 2016-03-25 | 2016-03-25 | |
| US62/313,334 | 2016-03-25 | ||
| PCT/US2017/023126 WO2017165255A1 (en) | 2016-03-25 | 2017-03-20 | Pyrimidines and variants thereof, and uses therefor |
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| KR20180128015A KR20180128015A (ko) | 2018-11-30 |
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| CA3018180C (en) | 2016-03-25 | 2024-02-20 | Ronald Charles Hawley | Pyrimidines and variants thereof, and uses therefor |
| DK3555048T3 (da) | 2016-12-19 | 2021-10-11 | Novartis Ag | Nye picolinsyrederivater og deres anvendelse som mellemprodukter |
| WO2018118668A1 (en) * | 2016-12-20 | 2018-06-28 | Afferent Pharmaceuticals, Inc. | Crystalline salts and polymorphs of a p2x3 antagonist |
| WO2019085916A1 (zh) * | 2017-11-01 | 2019-05-09 | 北京泰德制药股份有限公司 | P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途 |
| CN107778255B (zh) * | 2017-11-16 | 2019-10-25 | 山东大学 | 一种二芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法和应用 |
| MX2021013347A (es) * | 2019-04-30 | 2022-01-24 | Beijing Tide Pharmaceutical Co Ltd | Metodo para tratar el dolor asociado con endometriosis mediante el uso de un compuesto de diaminopirimidina. |
| EP3964505A4 (en) * | 2019-04-30 | 2022-12-21 | Beijing Tide Pharmaceutical Co., Ltd. | SOLID FORM OF DIAMINOPYRIMIDINE COMPOUND OR A HYDRATE THEREOF, METHOD FOR PREPARING IT AND APPLICATION |
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| WO2008104474A1 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Diaminopyrimidines |
| EP2203429A1 (en) * | 2007-10-31 | 2010-07-07 | Nissan Chemical Industries, Ltd. | Pyridazinone derivatives and use thereof as p2x7 receptor inhibitors |
| GB2471713A (en) | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| TWI637949B (zh) * | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| JP6546592B2 (ja) * | 2013-08-23 | 2019-07-17 | アファレント ファーマシューティカルズ インコーポレイテッド | 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンｐ２ｘ３およびｐ２ｘ２／３受容体モジュレーター |
| WO2016004358A1 (en) * | 2014-07-03 | 2016-01-07 | Afferent Pharmaceuticals, Inc. | Methods and compositions for treating diseases and conditions |
| MA43821A (fr) * | 2016-03-14 | 2018-11-28 | Afferent Pharmaceuticals Inc | Pyrimidines et variantes de celles-ci, et leurs utilisations |
| CA3018180C (en) | 2016-03-25 | 2024-02-20 | Ronald Charles Hawley | Pyrimidines and variants thereof, and uses therefor |
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2017
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|---|---|
| US20190055202A1 (en) | 2019-02-21 |
| CN108779119B (zh) | 2022-02-08 |
| US11230532B2 (en) | 2022-01-25 |
| AU2017237929B2 (en) | 2021-04-15 |
| RU2760733C2 (ru) | 2021-11-30 |
| US10662162B2 (en) | 2020-05-26 |
| JP6902045B2 (ja) | 2021-07-14 |
| RU2018137032A3 (es) | 2020-05-22 |
| CA3018180A1 (en) | 2017-09-28 |
| JP2019510025A (ja) | 2019-04-11 |
| RU2018137032A (ru) | 2020-04-27 |
| US20200239421A1 (en) | 2020-07-30 |
| KR20180128015A (ko) | 2018-11-30 |
| CA3018180C (en) | 2024-02-20 |
| MX2018011622A (es) | 2019-03-28 |
| BR112018069105A2 (pt) | 2019-01-29 |
| EP3433258A1 (en) | 2019-01-30 |
| CN108779119A (zh) | 2018-11-09 |
| AU2017237929A1 (en) | 2018-09-13 |
| EP3433258B1 (en) | 2023-07-19 |
| EP3433258A4 (en) | 2019-10-30 |
| MA44489A (fr) | 2019-01-30 |
| WO2017165255A1 (en) | 2017-09-28 |
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