KR102374500B1 - 바이오프테린 유도체를 포함하는 고체 약제학적 조성물 및 이러한 조성물의 용도 - Google Patents

바이오프테린 유도체를 포함하는 고체 약제학적 조성물 및 이러한 조성물의 용도 Download PDF

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KR102374500B1
KR102374500B1 KR1020167025896A KR20167025896A KR102374500B1 KR 102374500 B1 KR102374500 B1 KR 102374500B1 KR 1020167025896 A KR1020167025896 A KR 1020167025896A KR 20167025896 A KR20167025896 A KR 20167025896A KR 102374500 B1 KR102374500 B1 KR 102374500B1
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compound
formula
hpo
biopterin
phosphate
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KR20160138406A (ko
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피터 슐러
프랭크 테그트마이어
라인하르트 쉰젤
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바조팜 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020167025896A 2014-03-31 2015-03-30 바이오프테린 유도체를 포함하는 고체 약제학적 조성물 및 이러한 조성물의 용도 Active KR102374500B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14162727.3A EP2926805B1 (en) 2014-03-31 2014-03-31 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
EP14162727.3 2014-03-31
PCT/EP2015/056824 WO2015150294A1 (en) 2014-03-31 2015-03-30 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

Publications (2)

Publication Number Publication Date
KR20160138406A KR20160138406A (ko) 2016-12-05
KR102374500B1 true KR102374500B1 (ko) 2022-03-15

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KR1020167025896A Active KR102374500B1 (ko) 2014-03-31 2015-03-30 바이오프테린 유도체를 포함하는 고체 약제학적 조성물 및 이러한 조성물의 용도

Country Status (28)

Country Link
US (7) US9895372B2 (https=)
EP (2) EP2926805B1 (https=)
JP (3) JP6552515B2 (https=)
KR (1) KR102374500B1 (https=)
CN (2) CN106572976A (https=)
AU (2) AU2015239736B2 (https=)
CA (1) CA2938267C (https=)
CL (1) CL2016002463A1 (https=)
CY (1) CY1117881T1 (https=)
DK (1) DK2926805T3 (https=)
ES (1) ES2586945T3 (https=)
HR (1) HRP20160802T1 (https=)
HU (1) HUE030221T2 (https=)
IL (1) IL248090B (https=)
MX (1) MX377919B (https=)
MY (1) MY180844A (https=)
PE (1) PE20161253A1 (https=)
PH (1) PH12016501519A1 (https=)
PL (1) PL2926805T3 (https=)
PT (1) PT2926805T (https=)
RS (1) RS54973B1 (https=)
RU (1) RU2694368C2 (https=)
SA (1) SA516371933B1 (https=)
SG (1) SG11201606151SA (https=)
SI (1) SI2926805T1 (https=)
SM (1) SMT201600246B (https=)
WO (1) WO2015150294A1 (https=)
ZA (1) ZA201605271B (https=)

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Publication number Priority date Publication date Assignee Title
RU2733405C2 (ru) 2014-02-07 2020-10-01 Экзитера Фармасьютикалз Инк. Терапевтические соединения и композиции
ES2586945T3 (es) 2014-03-31 2016-10-19 Vasopharm Gmbh Composiciones farmacéuticas sólidas que comprenden derivados de biopterina y usos de dichas composiciones
JP2016168783A (ja) * 2015-03-13 2016-09-23 株式会社東芝 記録装置、記録方法、及び記録媒体
US12171766B2 (en) 2021-12-03 2024-12-24 Verinos Operations Gmbh Methods of treating patients suffering from brain injury and methods of increasing the value of the extended Glasgow Outcome Scale of patients suffering from brain injury
JP7811085B2 (ja) * 2017-09-01 2026-02-04 ピーティーシー セラピューティクス エムピー，インコーポレイテッド セピアプテリンを含む医薬組成物及びその使用
JP6565103B2 (ja) * 2017-09-06 2019-08-28 株式会社昭和冷凍プラント 香気成分含有水溶液を含む液状製品の製造方法
IL291565B1 (en) * 2019-09-25 2026-04-01 Ptc Therapeutics Inc Method for treating phenylalanine irregularity
WO2023099013A1 (en) 2021-12-03 2023-06-08 Verinos Operations Gmbh Methods of treating patients suffering from brain injury and methods of increasing the value of the extended glasgow outcome scale of patients suffering from brain injury
WO2023214091A1 (en) 2022-05-06 2023-11-09 Verinos Operations Gmbh Methods of treating patients suffering from a disease condition or disorder that is associated with an increased glutamate level

Citations (1)

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WO2004084906A1 (en) 2003-03-25 2004-10-07 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species

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ATE201412T1 (de) 1997-10-06 2001-06-15 Ernst Werner Pteridinderivate als no synthase-hemmer
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
EP1687308B1 (en) * 2003-11-17 2019-06-12 Merck & Cie Process for preparating (6R)-L-erythrotetrahydrobiopterin hydrochloride crystalline form B from other crystalline forms
US20080207624A1 (en) * 2004-05-11 2008-08-28 Osamu Sugita Therapeutic Agent for Bh4-Responsive Hyperphenylalaninemia
SE0401826D0 (sv) 2004-07-09 2004-07-09 Trimble Ab Method of preparing a winding for an n-phase motor
KR20070084270A (ko) * 2004-11-17 2007-08-24 바이오마린 파머수티컬 인크. 안정한 정제 제형물
EP1669355A1 (en) * 2004-12-02 2006-06-14 Vasopharm Biotech GmbH Aminotetrahydropteridines and processes for manufacture thereof
LT2545939T (lt) * 2007-04-11 2021-03-10 Biomarin Pharmaceutical Inc. Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiu
US8222828B2 (en) 2007-04-24 2012-07-17 Osram Ag Circuit arrangement for igniting and operating a discharge lamp
WO2010017570A2 (de) 2008-08-12 2010-02-18 Orpha Swiss Gmbh Pharmazeutische darreichungsform enthaltend tetrahydrobiopterin
CN103458900A (zh) 2011-03-01 2013-12-18 鲁必康研究私人有限公司 四氢生物蝶呤的稳定组合物
EP2750664A1 (en) * 2011-08-30 2014-07-09 Fresenius Kabi USA, LLC Levothyroxine formulations
ES2586945T3 (es) * 2014-03-31 2016-10-19 Vasopharm Gmbh Composiciones farmacéuticas sólidas que comprenden derivados de biopterina y usos de dichas composiciones

Patent Citations (1)

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WO2004084906A1 (en) 2003-03-25 2004-10-07 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species

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HK1213195A1 (en) 2016-06-30
US10016431B2 (en) 2018-07-10
US20200046710A1 (en) 2020-02-13
US11717522B2 (en) 2023-08-08
MX2016012784A (es) 2017-04-25
US20260048056A1 (en) 2026-02-19
IL248090A0 (en) 2016-11-30
PT2926805T (pt) 2016-07-15
PH12016501519B1 (en) 2017-02-06
PE20161253A1 (es) 2016-11-13
CY1117881T1 (el) 2018-03-07
AU2020203880A1 (en) 2020-07-02
PL2926805T3 (pl) 2016-12-30
HUE030221T2 (en) 2017-04-28
JP2017509623A (ja) 2017-04-06
US10925877B2 (en) 2021-02-23
US20230355630A1 (en) 2023-11-09
RS54973B1 (sr) 2016-11-30
EP3125864A1 (en) 2017-02-08
CN106572976A (zh) 2017-04-19
US12458644B2 (en) 2025-11-04
AU2015239736A1 (en) 2016-08-11
RU2016141449A (ru) 2018-05-07
JP6879582B2 (ja) 2021-06-02
RU2016141449A3 (https=) 2018-12-14
CA2938267A1 (en) 2015-10-08
ES2586945T3 (es) 2016-10-19
PH12016501519A1 (en) 2017-02-06
JP2019194227A (ja) 2019-11-07
CL2016002463A1 (es) 2017-01-27
AU2020203880B2 (en) 2022-03-31
NZ722455A (en) 2022-03-25
AU2015239736B2 (en) 2020-03-26
SI2926805T1 (sl) 2016-09-30
DK2926805T3 (en) 2016-07-25
SG11201606151SA (en) 2016-08-30
MY180844A (en) 2020-12-10
US20170296543A1 (en) 2017-10-19
KR20160138406A (ko) 2016-12-05
JP7178731B2 (ja) 2022-11-28
EP2926805B1 (en) 2016-05-18
CA2938267C (en) 2023-05-09
US20220031703A9 (en) 2022-02-03
JP2021105062A (ja) 2021-07-26
US10493075B2 (en) 2019-12-03
US20170112836A1 (en) 2017-04-27
RU2694368C2 (ru) 2019-07-12
BR112016020101A8 (pt) 2021-06-29
WO2015150294A1 (en) 2015-10-08
HRP20160802T1 (hr) 2016-08-12
JP6552515B2 (ja) 2019-07-31
US9895372B2 (en) 2018-02-20
IL248090B (en) 2019-10-31
US20180289714A1 (en) 2018-10-11
SMT201600246B (it) 2016-08-31
BR112016020101A2 (https=) 2017-07-15
SA516371933B1 (ar) 2019-04-14
US20210137927A1 (en) 2021-05-13
ZA201605271B (en) 2017-08-30
MX377919B (es) 2025-03-10
CN113521017A (zh) 2021-10-22
EP2926805A1 (en) 2015-10-07

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