KR102366682B1 - 죽상경화증의 치료를 위한 세마포린-4d 결합 분자의 용도 - Google Patents

죽상경화증의 치료를 위한 세마포린-4d 결합 분자의 용도 Download PDF

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KR102366682B1
KR102366682B1 KR1020167012123A KR20167012123A KR102366682B1 KR 102366682 B1 KR102366682 B1 KR 102366682B1 KR 1020167012123 A KR1020167012123 A KR 1020167012123A KR 20167012123 A KR20167012123 A KR 20167012123A KR 102366682 B1 KR102366682 B1 KR 102366682B1
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sema4d
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KR20160062167A (ko
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모리스 자우더러
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백시넥스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167012123A 2013-10-10 2014-10-10 죽상경화증의 치료를 위한 세마포린-4d 결합 분자의 용도 Active KR102366682B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361889421P 2013-10-10 2013-10-10
US61/889,421 2013-10-10
PCT/US2014/060129 WO2015054628A1 (en) 2013-10-10 2014-10-10 Use of semaphorin-4d binding molecules for treatment of atherosclerosis

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KR20160062167A KR20160062167A (ko) 2016-06-01
KR102366682B1 true KR102366682B1 (ko) 2022-02-22

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US (1) US9512224B2 (https=)
EP (1) EP3054976B1 (https=)
JP (2) JP6760840B2 (https=)
KR (1) KR102366682B1 (https=)
CN (1) CN105848679A (https=)
AU (1) AU2014331683B2 (https=)
BR (1) BR112016008010A2 (https=)
CA (1) CA2926944C (https=)
DK (1) DK3054976T3 (https=)
EA (1) EA037551B1 (https=)
ES (1) ES2821814T3 (https=)
IL (1) IL244976B (https=)
MX (1) MX385575B (https=)
NZ (1) NZ630881A (https=)
PT (1) PT3054976T (https=)
SG (1) SG11201602807PA (https=)
WO (1) WO2015054628A1 (https=)
ZA (1) ZA201602577B (https=)

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CN117597360A (zh) * 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
KR102847091B1 (ko) * 2022-08-25 2025-08-21 부산대학교 산학협력단 혈관석회화 동반 만성신부전에서 세마포린 4d의 용도
CN116949097B (zh) * 2023-09-20 2023-12-12 江苏集萃药康生物科技股份有限公司 一种sema4d人源化小鼠模型的构建方法及其应用

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ES2821814T3 (es) 2021-04-27
JP2019108359A (ja) 2019-07-04
ZA201602577B (en) 2020-11-25
SG11201602807PA (en) 2016-05-30
NZ630881A (en) 2016-03-31
IL244976A0 (en) 2016-05-31
WO2015054628A1 (en) 2015-04-16
AU2014331683B2 (en) 2019-07-11
CA2926944A1 (en) 2015-04-16
EA037551B1 (ru) 2021-04-13
JP2016539089A (ja) 2016-12-15
CA2926944C (en) 2023-08-08
DK3054976T3 (da) 2020-09-28
BR112016008010A2 (pt) 2017-09-26
IL244976B (en) 2020-07-30
EP3054976B1 (en) 2020-07-08
JP6760840B2 (ja) 2020-09-23
KR20160062167A (ko) 2016-06-01
US20150104462A1 (en) 2015-04-16
MX2016004551A (es) 2016-07-22
MX385575B (es) 2025-03-18
EA201690728A1 (ru) 2016-08-31
AU2014331683A1 (en) 2016-04-28
EP3054976A1 (en) 2016-08-17
CN105848679A (zh) 2016-08-10
US9512224B2 (en) 2016-12-06
PT3054976T (pt) 2020-08-05
EP3054976A4 (en) 2017-05-17

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