KR102366675B1 - Photoprotective composition - Google Patents

Abstract

The present invention relates to a topical photoprotective composition comprising baicalin or an extract containing the same together with at least one system for filtering UVA radiation. The present invention relates in particular to the field of cosmetics and/or cosmetic products. The present invention also relates to skin and/or lips and/or against solar radiation of baicalin or an extract containing the same in connection with at least one UVA radiation filtration system comprising at least one bis-resorcinyl triazine. It relates to a non-therapeutic cosmetic use for protecting hair.

Description

Photoprotective composition {PHOTOPROTECTIVE COMPOSITION}

The present invention relates to a topical photoprotective composition comprising baicalin or an extract containing the same together with at least one system for filtering UVA radiation. The present invention relates in particular to the field of cosmetics and/or cosmetic products.

The present invention also relates to skin and/or lips and/or against solar radiation of baicalin or an extract containing the same in connection with at least one UVA radiation filtration system comprising at least one bis-resorcinyl triazine. It relates to a non-therapeutic cosmetic use for protecting hair.

UV-A rays having a wavelength of 320 to 400 nm are known to cause skin soot and are prone to damage, especially in the case of sensitive skin or skin constantly exposed to solar radiation. UV-A rays in particular cause loss of skin elasticity and appearance of wrinkles, leading to premature aging of the skin. In this way, for cosmetic and cosmetic reasons, for example to preserve the natural elasticity of the skin, an increasing number of people are exploring to control the effects of UV-A radiation on their skin. Therefore, it is desirable to filter out UV-A radiation.

Light radiation having a wavelength in the range of 280 nm to 400 nm can cause soot in the human epidermis, more specifically light rays having a wavelength in the range of 280 to 320 nm and known as UV-B retard the development of natural soot It is also known to make For this reason and for cosmetic reasons, there is a consistent need for a means for regulating natural soot from the point of view of regulating skin color; Therefore, it is necessary to filter UV-B radiation.

In order to protect the skin and keratin materials against UV radiation, sunscreen compositions comprising organic filters active in the UV-A range and active in the UV-B range are generally used. Most of these filters are lipophilic, but also contain hydrophilic compounds.

There is room for further improvement of existing photoprotective compositions in protecting the skin against UV radiation, particularly UVA as well as UVB radiation.

In order to develop a cosmetic composition suitable for preventing premature skin aging, a solar filter, particularly a filter absorbing the UVA range, is effectively used. The use of these filters can reduce excessively photoinduced free radicals. However, the use of most compositions containing UV filters, especially UVA filters, does not provide complete protection. In this way, as a result of repeated exposure, residual amounts of free radicals that persist despite UVA filter protection can lead to long-term chemical change-causing aging phenomena. One solution might be to increase the amount of UVA filter, but it is not recommended to use excessively high levels of filters in daily cosmetic products.

Indeed, for most filters, once the maximum protection index is reached, it is very difficult to improve by increasing the filter ratio.

In this way, one would find means other than the use of large amounts of UV filters, especially UVA filters, in order to protect the skin against the sun's rays and effectively prevent premature aging of the skin under conditions and concentrations acceptable to those skilled in the art. Finding a solution for the purpose is still of interest.

In the prior art, the use of baicalin in cosmetic compositions, in particular photoprotective compositions, has already been suggested. This derives, inter alia, from a number of publications and patents such as the patent application JP 63083017 concerning the filtration action of some compounds including baicalin.

Shengzhao et al.; Study of application of baicalin in functional cosmetics, Shengzhao Gong; Yuke Jie; Shuiming Yuan, Riyong Huaxue Gongye (2003), 33(3), 200-203) and Feng-Jiao et al. -jiao et al.; Technology for preparation of sunscreen cream containing baicalin, Feng-jiao Sun; Ke-jian Liao; Yu-feng Cong; Yue-ling Dai; Feng Yan, Riyong Huaxue Gongye (2009), 39(4), 257-259) also relates to cosmetic compositions containing baicalin, more particularly to sun protection compositions.

Patent application DE102009037900 also describes cosmetic compositions comprising baicalin in association with various active ingredients. This document also describes the possibility of the additional existence of UV filtration agents, but does not draw any particular conclusions on this point.

International application WO 98/196651 describes a composition comprising a mineral (non-chemical) filter in the presence of proanthocyanidins, ferulic oryzanol and/or esters containing them and optionally a scutellaria extract . Although the possibility of using baicalin is mentioned; It is clear from the examples that a very specific combination of ethyl ferulate, pycnogenol, oryzanol and Scutellaria extract improves the skin protection factor (SPF). However, these photoprotective compositions comprising baicalin need further improvement in terms of protecting the skin against solar radiation, in particular UV.

Accordingly, there is still a need to find compositions, especially cosmetic compositions, that protect the skin against sun-induced damage.

It is an object of the present invention to solve the technical problem of providing a topical photoprotective composition and in particular a cosmetic composition.

It is also an object of the present invention to solve the technical problem of improving photoprotective compositions for protection of the skin and/or hair and/or lips against solar radiation, in particular UV.

It is a further object of the present invention to effectively prevent premature aging of the skin and/or lips and/or hair in conditions and concentrations acceptable to those skilled in the art, by means other than the use of a large amount of UV filters, in particular UVA filters. is to discover

A further object of the present invention is to prevent and/or prevent premature aging of the skin and/or lips due to ultraviolet rays and to protect the skin and/or lips and/or hair against this form of radiation and free radicals.

Accordingly, an object of the present invention is to solve these various technical problems.

Applicants have now surprisingly found that by linking baicalin or an extract containing the same with at least one UVA radiation filtration system comprising at least one bis-resorcinyl triazine derivative, the skin and/or against UV, in particular UVA radiation or to enhance the protection of lips and/or hair.

In this way, according to one of the objects of the present invention, topical photoprotection comprising at least one UVA radiation filtration system comprising baicalin or an extract containing it and at least one bis-resorcinyl triazine derivative A composition is provided. The present invention relates in particular to cosmetic compositions. The system for filtering UVA radiation advantageously further comprises at least one UVA filter selected from dibenzoylmethane derivatives, UVA filtering compounds from benzylidene camphor and mixtures of these two types of derivatives.

According to one preferred embodiment, the composition according to the invention further comprises at least one UVB filter, in particular a filter of the β,β′-diphenylacrylate type.

The composition according to the present invention is more specifically baicalin or an extract containing the same; at least one UVA radiation filtration system comprising at least one bis-resorcinyl triazine derivative, at least one dibenzoylmethane derivative, and at least one UVA filtering compound from benzylidene camphor; and in particular a composition comprising at least one UVB filter of the β,β′-diphenylacrylate type, and preferably baicalin or an extract containing it; and at least one UVA radiation filtration system comprising at least bis-ethylhexylphenol methoxyphenyltriazine, avobenzone, terephthalylidene dicamphor sulfonic acid; The composition further comprises octocrylene.

The composition according to the invention more particularly further comprises a UVA and/or UVB filtering compound. The composition according to the invention preferably further comprises cosmetically acceptable excipients.

The present invention also relates to a multi-component formulation for the photoprotection of human keratin materials (skin, lips, hair, eyelashes, eyebrows, nails) comprising separately packaged composition A and composition B; said composition A comprises at least baicalin or an extract in a cosmetically acceptable medium; wherein composition B comprises at least one UVA radiation filtration system comprising at least one bisresorcinyl triazine derivative in a cosmetically acceptable medium; The composition A and the composition B are applied simultaneously or sequentially onto the surface of the keratin material.

In the case of sequential application, composition A comprising baicalin is preferably applied first. The time interval between application of composition A and composition B is preferably from 1 hour to 48 hours, more preferably from 1 hour to 24 hours. Filtration composition B may be applied immediately prior to exposure to UV and in particular solar radiation.

The UVA radiation filtering system advantageously further comprises at least one UVA filter selected from dibenzoylmethane derivatives, UVA filtering compounds from benzylidene camphor and mixtures of these two types of derivatives.

Composition B according to the invention specifically comprises at least one UVA radiation comprising at least one bis-resorcinyl triazine derivative, at least one dibenzoylmethane derivative and at least one UVA filtering compound from benzylidene camphor. It contains a filtration system.

According to one preferred embodiment, the composition according to the invention further comprises at least one UVB filter, in particular a filter of the β,β′-diphenylacrylate type.

According to one preferred embodiment, composition B according to the invention comprises at least one UVA radiation filtration system comprising at least bis-ethylhexylphenol methoxyphenyltriazine, avobenzone, terephthalylidene dicamphor sulfonic acid, ; The composition further comprises octocrylene.

Composition B according to the invention more particularly further comprises UVA and/or UVB filtering compounds. The composition according to the invention preferably further comprises cosmetically acceptable excipients.

It is a further object of the present invention to protect the skin and/or lips and/or hair against solar radiation and/or to prevent or prevent photoinduced premature aging of the skin and/or lips and/or hair. -to the cosmetic, non-therapeutic use of baicalin or an extract containing same in connection with at least one UVA radiation filtration system comprising resorcinyl triazine.

The present invention also relates to a human keratinous substance of a composition or multi-component preparation according to the invention for preventing or preventing photoinduced premature aging of human keratinous substance (skin, lips, hair, eyelashes, eyebrows, nails) ( to a method for cosmetic and/or cosmetic treatment comprising topical application to skin, lips, hair, eyelashes, eyebrows, nails).

The present invention also relates to human keratin materials (skin, lips, It relates to a method of cosmetic and/or cosmetic treatment comprising topical application to hair, eyelashes, eyebrows, nails).

Additional features, aspects and advantages of the present invention will become apparent upon reading the following detailed description.

Justice

The term UV (UVA and/or UVB) radiation filtration system refers to at least a portion of said radiation emitted by the sun to protect the skin and/or lips and/or hair against the harmful effects of UV (UVA and/or UVB) radiation. A substance that can absorb

The UVA radiation wavelength is different from the UVB radiation wavelength. The wavelength of UVA radiation is 400 nm to 315 nm, and UVB is 315 nm to 280 nm.

The term “associated” compound or “association” of a compound refers to the presence of the referenced compound in the same composition or in separate compositions that are applied sequentially or simultaneously.

The term “cosmetically acceptable” refers to the skin and/or its integument which has a pleasant color, fragrance and texture and which does not cause unacceptable discomfort (tingling, tightness, redness) that would dissuade the consumer from using the composition. compatibility with

The compositions according to the invention, in particular compositions A and/or B, may additionally comprise further supplementary organic or inorganic UV filters which are active in the UVA and/or UVB range and are hydrophilic or lipophilic or insoluble in customary cosmetic solvents. can

The term “lipophilic UV filter” refers to any cosmetic or dermatological filter that is susceptible to complete dissolution in the molecular state in the liquid fat phase or to solubilization in the colloidal form (eg micellar form) in the liquid fat phase.

The term "hydrophilic UV filter" refers to any cosmetic or dermatological filter that is susceptible to complete dissolution in the molecular state in the liquid aqueous phase or to solubilization in colloidal form (eg, micellar form) in the liquid aqueous phase.

The term "insoluble UV filter" is not defined as a lipophilic UV filter or a hydrophilic UV filter and refers to any cosmetic or dermatological filter in the form of particles in the liquid aqueous or fatty phase.

The invention is embodied below with reference to a more general description of the invention.

Baicalin is represented by the formula:

Baicalin is available from, for example, MMP or Guilin Layn Natural Ingredients Corp. This compound is particularly described in application WO 2008/140440 in the form of a particularly stable solution. Baicalin may be used in the form of a stable solution comprising a glycol alkyl having 2 to 7 carbon atoms, a polyol ether, and at least one antioxidant.

These organic compounds can be obtained as described in EP 1400 579 (US2004/0067894) on the synthesis of tetrahydroxyflavones, wherein the general formula includes baicalin.

Baicalin may be used in the form of an extract of plant origin. Baicalin is based on traditional Chinese medicine, especially the skull cap root ( scutellaria ). and in particular polyphenols (flavones) extracted from scutellaria baicalensis .

The bis-resorcinyl triazine compound according to the present invention preferably exhibits the structure of the formula (I):

in the above formula

(i) the same or different radicals R ₁ and R ₂ are C ₃ -C ₁₈ alkyl radicals; refers to a C ₂ -C ₁₈ alkenyl radical or a moiety representing the formula —CH ₂ —CH(OH)—CH ₂ —OT ₁ , wherein T ₁ is a hydrogen atom or a C ₁ -C ₈ alkyl radical;

(ii) the same or different radicals R ₁ and R ₂ may also refer to moieties represented by the formula (1):

From here

- R ₆ is a covalent bond; C ₁ -C ₄ linear or branched alkyl radical or moiety representing the formula -C _m1 H _2m1 -O- , wherein m ₁ is a number from 1 to 4;

- p ₁ is a number from 0 to 5;

- the same or different radicals R ₇ , R ₈ and R ₉ are C ₁ -C ₁₈ alkyl radicals; refers to a C ₁ -C ₁₈ alkoxy radical or a moiety represented by the formula (2):

wherein R ₁₀ is a C ₁ -C ₅ alkyl radical;

- A ₁ refers to a moiety representing any of the following formulas:

From here

- R ₃ is a hydrogen atom, a C ₁ -C ₁₀ alkyl radical, a radical of the formula -(CH ₂ CHR ₅ -O) _n1 R ₄ (wherein n ₁ is a number from 1 to 16), or the structure -CH ₂ - refers to the residue of CH-(OH)-CH ₂ OT ₁ , wherein T ₁ has the same meaning as mentioned above,

- R ₄ is hydrogen, a metal cation M, a C ₁ -C ₅ alkyl radical or of the formula -(CH ₂ )m ₂ -OT ₁ , wherein m ₂ is a number from 1 to 4 and T ₁ has the same meaning as mentioned above refers to the residue of),

- Q ₁ is a C ₁ -C ₁₈ alkyl radical.

In the aforementioned formulas (I) and (1) to (5),

- the alkyl radical is linear or branched, for example methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, amyl, isoamyl, tert-amyl, heptyl, octyl, iso octyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl or octadecyl;

- the alkenyl radical is for example allyl, methallyl, isopropenyl, 2-butenyl, 3-butenyl, isobutenyl, n-penta-2,4-dienyl, 3-methyl-but-2-enyl , n-oct-2-enyl, n-dodec-2-enyl, iso-dodecenyl, n-octadec-4-enyl;

- the alkoxy radical is linear or branched, for example methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, amyloxy, isoamyloxy or tert-amyloxy;

- a C ₁ -C ₅ mono or dialkylamino radical is for example methylamino, ethylamino, propylamino, n-butylamino, sec-butylamino, tert-butylamino, pentylamino, dimethylamino, diethylamino, may be selected from dibutylamino or methylethylamino,

- The metal cation is, for example, an alkali metal, alkaline earth metal or metal cation selected from lithium, potassium, sodium, calcium, magnesium, copper and zinc.

The bis-resorcinyl triazine derivatives of formula (I) according to the invention are filters already known per se. They are prepared according to the synthetic methods described and presented in patent application EP-A-0775 698.

Examples of compounds of formula (I) suitable for use are:

- 2,4-bis{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxy-phenyl)-1,3,5-triazine;

- 2,4-bis{[4-(3-(2-propyloxy)-2-hydroxy-propyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1, 3,5-triazine;

- 2,4-bis{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-[4-(2-methoxyethyl-carboxyl)-phenylamino]-1, 3,5-triazine;

- 2,4-bis{[4-tris(trimethylsiloxy-silylpropyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine;

- 2,4-bis{[4-(2"-methylpropenyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine;

- 2,4-bis{[4-(1',1',1',3',5',5',5'-heptamethyltrisiloxy-2"-methylpropyloxy)-2-hydroxy ]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine.

- 2,4-bis{[4-(3-(2-propyloxy)-2-hydroxy-propyloxy]-2-hydroxy]-phenyl}-6-[(4-ethylcarboxyl)-phenylamino ]-1,3,5-triazine;

- 2,4-bis{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(1-methylpyrrol-2-yl)-1,3,5-triazine .

More specifically, at least the compound 2,4-bis{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxy-phenyl)-1,3,5 Products such as -triazine® or bis-ethylhexyloxyphenol methoxyphenyl triazine (INCI name) are marketed by CIBA GEIGY under the trade name "TINOSORB S".

The bis-resorcinyl triazine compound(s) of formula (I) are generally from 0.1 to 20% by weight and more preferably from 1 to 10% by weight and more particularly from 2 to 8% by weight, based on the total weight of the composition. It is present in the filtration composition according to the invention in a concentration in the range of %.

Dibenzoylmethane derivatives include, but are not particularly limited to:

- 2-methyldibenzoylmethane,

- 4-methyldibenzoylmethane,

- 4-isopropyldibenzoylmethane,

- 4-tert-butyldibenzoylmethane,

- 2,4-dimethyldibenzoylmethane;

- 2,5-dimethyldibenzoylmethane;

- 4,4'-diisopropyldibenzoylmethane,

- 4,4'-dimethoxydibenzoylmethane,

- 4-tert-butyl-4'-methoxydibenzoylmethane,

- 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane,

- 2-methyl-5-tert-butyl-4'-methoxydibenzoylmethane,

- 2,4-dimethyl-4'-methoxydibenzoylmethane,

- 2,6-Dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane.

Among the above-mentioned dibenzoylmethane derivatives, use is made, for example, of 4-isopropyl-dibenzoylmethane sold under the trade name "EUSOLEX 8020" by MERCK and having the formula:

Particular preference is given to at least 4-(ter-butyl) 4′-methoxy dibenzoylmethane or butyl methoxy dibenzoylmethane sold under the trade designation “PARSOL 1789” by DSM Nutritional Products, Inc. using benzoylmethane or avobenzone; This filter exhibits the formula:

The dibenzoylmethane derivative(s) may preferably be present in the composition according to the invention in a content ranging from 0.01 to 10% by weight and more preferably from 0.1 to 6% by weight, based on the total weight of the composition.

Benzylidene camphor derivatives include:

3-benzylidene camphor manufactured under the name "MEXORYL SD" by CHIMEX,

4-methylbenzylidene camphor sold under the trade name "EUSOLEX 6300" by Merck;

benzylidene camphor sulfonic acid manufactured under the name "MEXORYL SL" by chimex,

camphor benzalkonium methosulfate, manufactured under the name "MEXORYL SO" by chimex,

Polyacrylamidomethyl benzylidene camphor manufactured by CIMEX under the name "MEXORYL SW".

Preference is given to using at least the terephthalylidene dicamphor sulfonic acid sold under the trade name MEXORYL SX by Chimex.

The invention may further comprise at least one UVB filter and in particular at least one β,β′-diphenylacrylate derivative. A lipophilic UVB filter is preferred.

β,β′-diphenylacrylate derivatives include in particular etocrylene sold under the trade name “UVINUL N35” by BASF. It is preferred to use at least octocrylene as UVB filter. Octocrylene is marketed in particular by BASF under the trade name “UVINUL N539”.

The composition according to the invention filters wavelengths in the UVA and/or UVB range and additionally comprises a supplementary organic or inorganic photoprotective agent, which is hydrophilic or lipophilic or insoluble in common cosmetic solvents and is also known as a filter or filter. can do.

Supplementary organic filters are especially anthranilic; cinnamic derivatives; salicylic derivatives; benzophenone derivatives; phenyl benzotriazole derivatives; benzalmalonate derivatives, especially those mentioned in patent US5624663; phenyl benzimidazole derivatives; imidazoline; 4,4-diarylbutadiene derivatives; bis-benzoazolyl derivatives described in patents EP669323 and US 2,463,264; p-aminobenzoic acid (PABA) derivatives; methylene bis-(hydroxyphenyl benzotriazole) derivatives described in applications US5,237,071, US5,166,355, GB2303549, DE 197 26 184 and EP893119; benzoxazole derivatives described in patent applications EP0832642, EP1027883, EP1300137 and DE10162844; In particular filter polymers and filter silicones such as those described in application WO-93/04665; dimers derived from α-alkylstyrene as described in patent application DE19855649; 4,4-diarylbutadiene as described in applications EP0967200, DE19746654, DE19755649, EP-A-1008586, EP1133980 and EP1339814; merocyanine derivatives as described in WO04006878, WO05058269 and WO06032741 and mixtures thereof.

Examples of organic UV filters include those referred to below using their INCI names:

UVA and/or UVB Classification according to radiation wavelength range

I/ Lipophilic UV-A Filter

Dibenzoylmethane 　Derivatives:

isopropyl dibenzoylmethane;

aminobenzophenone :

n-hexyl 2-(4-diethylamino-2-hydroxybenzoyl)-benzoate sold especially by BASF under the trade name "UVINUL A +";

1,1'-(1,4-piperazindiyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone (CAS 　919803-06-8)

anthranil derivative:

Menthyl anthranilate sold in particular under the trade name "NEO HELIOPAN MA" by SYMRISE;

4,4- diarylbutadiene derivative:

1,1-dicarboxy (2,2'-dimethyl-propyl)-4,4-diphenylbutadiene;

Merocyanine derivative:

octyl-5-N,N-diethylamino-2-phenylsulfonyl-2,4-pentadienoate;

Within the scope of the present invention, and according to one particular embodiment, the following lipophilic filter is used:

Butyl Methoxydibenzoylmethane

II/ Hydrophilic UV-A filter

The bis-benzoazolyl derivatives described in patents EP 669 323 and US 2,463,264 and more particularly the compound disodium phenyl dibenzimidazo tetrasulfonate sold under the trade name "NEO HELIOPAN AP" by Symrise.

A preferred hydrophilic UVA filter is terephthalylidene dicamphor sulfonic acid.

III/ lipophilic UV-B filter

Para-Aminobenzoate:

ethyl PABA;

ethyl dihydroxypropyl PABA;

ethylhexyl dimethyl PABA (ESCALOL 507 from ISP);

Salicylic derivative:

In particular, the homosalate sold under the trade name “Eusolex HMS” by Rona/EM Industries;

In particular, ethylhexyl salicylate sold under the trade name "NEO HELIOPAN OS" by Symrise;

dipropyleneglycol salicylate sold in particular under the trade name "DIPSAL" by SCHER;

TEA salicylate sold under the trade name "NEO HELIOPAN TS" by Symrise;

Cinnamate

ethylhexyl methoxycinnamate sold in particular under the trade designation "PARSOL MCX" by DSM Nutritional Products, Inc.;

isopropyl methoxy cinnamate;

In particular, isoamyl methoxy cinnamate sold under the trade name "NEO HELIOPAN E 1000" by Symrise;

diisopropyl methylcinnamate;

cinnoxate;

glyceryl ethylhexanoate dimethoxycinnamate;

β, β '- diphenyl acrylate derivative:

In particular, etocrylene sold under the trade name “UVINUL N35” by BASF;

benzylidene camphor derivative:

3-benzylidene camphor, manufactured under the name "MEXORYL SD" by CIMEX;

methylbenzylidene camphor sold under the trade name “EUSOLEX 6300” by Merck;

polyacrylamidomethyl benzylidene camphor manufactured under the designation "MEXORYL SW" by Chimex;

Triazine 　 derivatives:

ethylhexyl triazone sold in particular by BASF under the trade name "UVINUL T150";

diethylhexyl butamido triazone sold in particular under the trade name “UVASORB HEB” by SIGMA 3V;

2,4,6-tris(dineopentyl 4'-amino benzalmalonate)-s-triazine;

2,4,6-tris(diisobutyl 4′-amino benzalmalonate)-s-triazine;

2,4-bis(dineopentyl 4′-amino benzalmalonate)-6-(n-butyl 4′-aminobenzoate)-s-triazine;

2,4-bis(n-butyl 4′-amino benzoate)-6-(aminopropyltrisiloxane)-s-triazine;

Patent US 6,225,467, application WO 2004/085412 (see compounds 6 and 9) or in the literature (“Symmetrical Triazine Derivatives” IP.COM Journal, IP.COM INC WEST HENRIETTA, NY, US (September 20, 2004)) symmetrical triazine filters, in particular 2,4,6-tris-(biphenyl)-1,3,5-triazine (in particular 2,4,6-tris(biphenyl-4-yl-1, 3,5-triazine) and 2,4,6-tris(terphenyl)-1,3,5-triazine, these two filters are disclosed in BEIERSDORF applications WO 06/035000, WO 06/ 034982, WO 06/034991, WO 06/035007, WO 2006/034992, WO 2006/034985).

imidazoline derivative:

ethylhexyl dimethoxybenzylidene dioxoimidazoline propionate;

Benzalmalonate derivative:

In particular, polyorganosiloxanes having benzalmalonate functionality such as polysilicon-15 sold under the trade designation "PARSOL SLX" by DSM Nutritional Products, Inc.;

di-neopentyl 4'-methoxybenzalmalonate;

Within the scope of the invention, and according to one particular embodiment, the following lipophilic UV-B filters are used in the composition according to the invention:

ethylhexyl salicylate;

octocrylene;

Ethylhexyl Triazone.

IV/ Hydrophilic UV-B Filter

The following p-aminobenzoic acid (PABA) derivatives:

PABA,

glyceryl PABA and

In particular, PEG-25 PABA sold under the trade name "UVINUL P25" by BASF,

In particular, phenylbenzimidazole sulfonic acid sold under the trade name "EUSOLEX 232" by Merck;

ferulic acid,

salicylic acid,

DEA methoxycinnamate,

benzylidene camphor sulfonic acid manufactured under the name "MEXORYL SL" by chimex,

camphor benzalkonium methosulfate, manufactured under the name "MEXORYL SO" by chimex,

A preferred hydrophilic UVB filter is phenylbenzimidazole sulfonic acid.

V/ combined lipophilic UVA and UVB filter

benzophenone derivatives

In particular, benzophenone-1 sold under the trade name “UVINUL 400” by BASF;

In particular, benzophenone-2 sold under the trade name “UVINUL D50” by BASF;

benzophenone-3 or oxybenzone sold in particular by BASF under the trade name "UVINUL M40";

In particular, benzophenone-6 sold under the trade name “Helisorb 11” by Norquay;

In particular, benzophenone-8 sold under the trade name “Spectra-Sorb UV-24” by American Cyanamid;

benzophenone-10;

benzophenone-11;

benzophenone-12;

phenyl benzotriazole derivative:

dromethrizole trisiloxane sold in particular by RHODIA CHIMIE under the trade name "Silatrizole" or manufactured by Chimex under the name "Meroxyl XL";

Marketed in particular in solid form under the trade name "MIXXIM BB/100" by FAIRMOUNT CHEMICAL or micronized in an aqueous dispersion, in particular under the trade name "TINOSORB M" by CIBA SPECIALTY CHEMICALS ) methylene bis-benzotriazolyl tetramethylbutylphenol sold in the form;

benzoxazole 　 derivatives:

2,4-bis-[5-1(dimethylpropyl)benzoxazol-2-yl-(4-phenyl)-imino]-6-(2-ethyl) sold especially by Sigma 3V under the trade name Uvasorb K2A hexyl)-imino-1,3,5-triazine.

Preferred lipophilic organic UVA and UVB filters are selected from:

dromethrizole trisiloxane;

methylene bis-benzotriazolyl tetramethylbutylphenol;

Bis-ethylhexyloxyphenol methoxyphenyl triazine.

VI/ Combined Hydrophilicity UVA and UVB filter

benzophenone derivatives comprising at least one sulfonic radical, for example,

In particular, benzophenone-4 sold under the trade name "UVINUL MS 40" by BASF,

benzophenone-5 and

Benzophenone-9.

The composition according to the invention may also comprise a mineral filter which is a pigment. Pigments may or may not be coated.

The coated pigments can be formulated with compounds described, for example, in the literature (Cosmetics & Toiletries, February 1990, Vol. 105, p. 53-64), for example amino acids, beeswax, fatty acids, fatty alcohols, anionic surfactants, lecithins, by sodium, potassium, zinc, iron or aluminum salts of fatty acids, metals (titanium or aluminum), alkoxides, polyethylene, silicones, proteins (collagen, elastin), alkanolamines, silicon oxides, metal oxides or sodium hexametaphosphate Pigments that have been subjected to one or more chemical, electronic, mechanochemical and/or mechanical surface treatments.

According to the prior art, silicones are organosilicate polymers or oligomers with variable molecular weights, exhibiting a linear or cyclic, branched or crosslinked structure, obtained by polymerization and/or polycondensation of suitably functionalized silanes, which Consists of essentially repeating primary structural units, wherein silicon atoms are interconnected by oxygen atoms (siloxane bonds) and optionally substituted hydrocarbon radicals are bonded directly via carbon atoms on said silicon atoms.

The term “silicone” also encompasses the silanes necessary for their preparation, especially alkylsilanes.

The silicone used to coat the pigments suitable for the present invention is preferably selected from the group containing alkyl silanes, polydialkylsiloxanes and polyalkylhydrogen siloxanes. More preferably, the silicone is selected from the group containing octyl trimethyl silane, polydimethylsiloxane and polymethylhydrogen siloxane.

Obviously, before treating it with silicone, the metal oxide pigment can be treated with other surface agents, in particular cerium oxide, alumina, silica, aluminum compounds, silicon compounds or mixtures thereof.

The coated pigment is, for example, titanium oxide coated with:

- silica, for example the product "SUNVEIL" from IKEDA and the product "Eusolex T-AVO" from Merck,

- silica and iron oxides, for example "SUNVEIL F" from Ikeda,

- silica and alumina, for example "MICROTITANIUM DIOXIDE MT 500 SA" and "MICROTITANIUM DIOXIDE MT 100 SA" from TAYCA, "TIOVEIL" from TIOXIDE, and from Rhodia "Mirasun TiW 60",

- alumina, for example the products "TIPAQUE TTO-55 (B)" and "TIPAQUE TTO-55 (A)" from ISHIHARA, and the products "UVT 14/4" from KEMIRA,

- alumina and aluminum stearate, for example "MICROTITANIUM DIOXIDE MT-100 TV, MT 100 TX, MT 100 Z, MT-01" from Taica, "Solaveil CT-10 W" from UNIQEMA, "Solaveil CT 100" and "Solaveil CT 200";

- silica, alumina and alginic acid, for example the product "MT-100 AQ" from Taika;

- alumina and aluminum laurate, for example "MICROTITANIUM DIOXIDE MT 100 S" from Taika;

- iron oxides and iron stearate, for example "MICROTITANIUM DIOXIDE MT 100 F" from Taika,

- zinc oxide and zinc stearate, for example the product "BR351" from Taica,

- silica and alumina treated with silicone, for example "MICROTITANIUM DIOXIDE MT 600 SAS", "MICROTITANIUM DIOXIDE MT 500 SAS" or "MICROTITANIUM DIOXIDE MT 100 SAS" from Taika;

- silica, alumina, aluminum stearate treated with silicone, for example "STT-30-DS" from TITAN KOGYO,

- silica treated with silicone, for example the product "UV-TITAN X 195" from Chemira, or the product SMT-100 WRS from Taika;

- alumina treated with silicone, for example the product "TIPAQUE　　TTO-55 (S)" from Ishihara, or the product "UV TITAN M　262" from Chemira;

- triethanolamine, for example "STT-65-S" from Titan Kogyo,

- stearic acid, for example "TIPAQUE TTO-55　(C)" from Ishihara,

- Sodium hexametaphosphate, for example "MICROTITANIUM　　DIOXIDE　MT 150　W" from Taika.

Additional titanium oxide pigments treated with silicone are, for example, TiO ₂ treated with octyl trimethyl silane, such as those sold under the trade name “T 805” by DEGUSSA SILICES, CARDRE. TiO ₂ treated with polydimethylsiloxane as sold under the trade name "70250 Cardre UF TiO2SI3" by COLOR TECHNIQUES under the trade name "MICROTITANIUM DIOXYDE USP GRADE HYDROPHOBIC" by polydimethylhydrogen siloxane Treated anatase/rutile TiO ₂ .

Uncoated titanium oxide pigments can be obtained, for example, under the trade name "MICROTITANIUM DIOXIDE MT 500 B" or "MICROTITANIUM DIOXIDE MT600 B" sold by Taika, under the trade name "P 25" sold by Degusa, WACKHER ) sold under the trade name "Oxyde de titane transparent PW", marketed by MIYOSHI KASEI under the trade name "UFTR", marketed by TOMEN under the trade name "ITS" and marketed by TIOXIDE Trade name "TIOVEIL AQ".

Uncoated zinc oxide pigments are, for example:

- products marketed under the trade name "Z-cote" by Sunsmart;

- the product marketed under the trade name "Nanox" by Elementis;

- The product marketed under the trade name "Nanogard WCD 2025" by Nanophase Technologies.

Coated zinc oxide pigments are, for example:

- the product sold under the trade name "Z-COTE HP1" by Sunsmart (ZnO coated with dimethicone);

- the product sold under the trade name "CS-5 zinc oxide" by Toshibi (ZnO coated with polymethylhydrogen siloxane);

- the product sold under the trade name "Nanogard Zinc Oxide FN" by Nanophase Technologies (Finsolv TN, 40% dispersion in C12-C15 alcohol benzoate);

- products sold under the trade names "DAITOPERSION ZN-30" and "DAITOPERSION Zn-50" by Daito (dispersion in cyclopolymethylsiloxane/oxyethylenated polydimethylsiloxane, coated with silica and polymethylhydrogen siloxane 30% or 50% zinc oxide);

- the product sold under the trade name "NFD Ultrafine ZnO" by Daikin (ZnO coated with perfluoroalkyl phosphate and perfluoroalkylethyl based copolymer, dispersed in cyclopentasiloxane);

- the product sold under the trade name "SPD-Z1" by Shin-Etsu (ZnO dispersed in cyclodimethylsiloxane and coated with a silicone-grafted acrylic polymer);

- the product sold by the ISP under the trade name "Escalol Z100" (ZnO dispersed in ethylhexyl methoxycinnamate / PVP-hexadecene copolymer / methicone mixture and treated with alumina);

- the product sold under the trade name "Fuji ZnO-SMS-10" by Fuji Pigment (ZnO coated with silica and polymethylsilsesquioxane);

- the product sold under the trade name "Nanox Gel TN" by Elementis (ZnO as a 55% dispersion in C12-C15 alcohol benzoate with hydroxystearic acid polycondensate).

Uncoated cerium oxide pigments are sold, for example, under the trade name "COLLOIDAL CERIUM OXIDE" by RHONE POULENC.

Uncoated iron oxide pigments are produced, for example, under the trade names "NANOGARD WCD 2002 (FE 45B)", "NANOGARD IRON FE 45 BL AQ", "NANOGARD FE 45R AQ", "NANOGARD WCD 2006 by ARNAUD." (FE 45R)" or by MITSUBISHI under the trade designation "TY-220".

Coated iron oxide pigments are, for example, under the trade names “NANOGARD WCD 2008 (FE 45B FN)”, “NANOGARD WCD 2009 (FE 45B 556)”, “NANOGARD FE 45 BL 345”, “NANOGARD FE 45” by Arnault. BL" or under the trade name "TRANSPARENT IRON OXIDE" by BASF.

Mixtures of metal oxides, in particular mixtures of equal weights of titanium dioxide and titanium dioxide coated with titanium dioxide and cerium dioxide, for example silica sold under the trade name "SUNVEIL A" by Ikeda, and the products marketed by Chemira It is also possible to refer to mixtures of zinc dioxide and titanium dioxide coated with alumina, silica and silicone, such as "M 261" or coated with alumina, silica and glycerin, such as the product "M 211" sold by Chemira .

Pigments can be introduced into the composition according to the invention, either as such or in the form of a pigment paste, ie in admixture with a dispersant, as described, for example, in document GB-A-2206339.

The additional UV filter is generally present in the composition according to the invention in a proportion in the range from 0.01 to 20% by weight, based on the total weight of the composition, preferably in the range from 0.1 to 10% by weight, based on the total weight of the composition.

The composition may further comprise at least one additional ingredient intended to provide an immediate visual effect. These include in particular fillers with a soft-focus effect or natural pinkish skin tone enhancers.

Natural pinkish skin tone enhancers are, for example, self-tanning agents, ie, tanning somewhat similar to those likely to occur as a result of prolonged exposure to the sun (natural tanning) or UV lamps when applied to the skin, particularly the face. It includes agents capable of obtaining an effect.

Examples of self-tanning agents include in particular:

dihydroxyacetone (DHA);

erythrulose, and

Linkage of a catalyst system formed from:

manganese and/or zinc salts and oxides, and

Alkali metal and/or alkaline earth metal hydrogen carbonates.

Self-tanning agents are generally mono or polycarbonyl compounds such as isatin, alloxane, ninhydrin, glyceraldehyde, mesotartaric aldehyde, glutaraldehyde, erythrulose, patent application FR 2 466 Pyrazoline-4,5-dione derivatives described in 492 and WO 97/35842, dihydroxyacetone (DHA), 4,4-dihydroxypyrazolin-5-one derivatives described in patent application EP 903 342 is selected from DHA is preferably used.

DHA can be used in free and/or encapsulated form, in particular in lipid vehicles such as liposomes as described in application WO 97/25970.

In general, the self-tanning agent, in particular DHA, is present in an amount ranging from 0.01 to 20% by weight, and preferably from 0.1 to 10% by weight of the total weight of the composition.

Additional colorants suitable for altering the color produced by the self-tanning agent may be used.

These colorants may be selected from synthetic or natural direct colorants.

These colorants may be selected, for example, from red or orange fluorane type colorants, such as those described in patent application FR2840806. For example, it includes the following colorants:

- tetrabromofluorocein or eosin known by CTFA name: CI 45380 or Red 21;

- CTFA designation: Phloxin B, known as CI 45410 or Red 27;

- diiodofluorescein known by the CTFA name CI 45425 or Orange 10;

- dibromofluorescein known by CTFA name: CI 45370 or orange 5;

- tetrabromofluorocein sodium salt known by CTFA name: CI 45380 (Na salt) or red 22;

- Phloxin B sodium salt known by CTFA name: CI 45410 (Na salt) or Red 28;

- diiodofluorescein sodium salt known by CTFA name: CI 45425 (Na salt) or orange 11;

- erythrosine known by CTFA name: CI 45430 or Acid Red 51;

- Phloxin known by CTFA name: CI 45405 or Acid Red 98.

These colorants may be selected from anthraquinone, caramel, carmine, carbon black, azulene blue, methoxalene, trioxalene, guazazulene, chamuzulene, rose bengal, cosine 10B, cyanosine, daffinin.

These colorants include monohydroxyindole as described in patent FR2651126 (ie: 4-, 5-, 6- or 7-hydroxyindole) or dihydroxyindole as described in patent EP-B-0425324 (ie: 5,6). -selected from indole derivatives such as dihydroxyindole, 2-methyl 5,6-dihydroxyindole, 3-methyl 5,6-dihydroxyindole, 2,3-dimethyl 5,6-dihydroxyindole) it might be

The composition according to the invention comprises fatty substances, in particular oils, waxes, organic solvents, ionic or nonionic thickeners, hydrophilic or lipophilic emollients, humectants, opacifiers, stabilizers, emollients, silicones, defoamers, perfumes, preservatives, anionic , cationic, nonionic, zwitterionic or amphoteric surfactants, active substances, fillers, polymers, propellants, alkalizing or acidifying agents or any other ingredients customarily used in the cosmetic and/or dermatological field. of cosmetic adjuvants may be further included.

Fatty substances may consist of oils or waxes or mixtures thereof. The term oil refers to a compound that is liquid at ambient temperature. The term wax refers to a compound that is solid or substantially solid at ambient temperature, wherein the melting point is generally greater than 35°C.

Oils include, for example, mineral oil (paraffin oil); vegetable oils (persimmons, macadamia, blackberry seeds, jojoba); synthetic oils, such as perhydrosqualene, fatty alcohols, fatty amides (eg, isopropyl lauroyl sarcosinate sold under the trade name "Eldew SL-205" by Ajinomoto), fatty acids or esters; C12-C15 alcohol benzoate, 2-ethylphenyl benzoate, sold eg by WITCO under the trade name “Finsolv TN” or “Witconol TN”, eg by ISP under the trade name X-TEND 226 Commercial products sold as ^® , octyl palmitate, isopropyl ranolate, triglycerides including those of capric/caprylic acid, dicaprylyl carbonate sold under the trade name "Cetiol CC" by Cognis, oxy ethylene or oxypropylene fatty esters and ethers; silicone oils (cyclomethicone, polydimethylsiloxane or PDMS) or fluorinated oils, polyalkylenes, trialkyl trimellitates such as tridecyl trimellitate.

Waxes include, for example, carnauba wax, beeswax, hydrogenated castor oil, polyethylene wax and polymethylene wax, such as those sold under the trade designation “Cirebelle 303” by SASOL.

Organic solvents include, for example, lower alcohols and polyols. They may be selected from glycols and glycol ethers, for example ethylene glycol, propylene glycol, butylene glycol, dipropylene glycol or diethylene glycol.

Hydrophilic thickeners include, for example, carboxyvinyl polymers such as carbopol (carbomer) and pemulene (acrylate/C10-C30-alkylacrylate copolymer); Polyacrylamides, for example by Seppic under the trade name Sepigel 305 (CTFA name: polyacrylamide/C13-14 isoparaffin/lauret 7) or Simulgel 600 (CTFA name: acrylamide/sodium acryloyldimethyl crosslinked copolymers marketed as taurate copolymer/isohexadecane/polysorbate 80); Optionally crosslinked and/or neutralized 2-acrylamido 2-methylpropane sulfonic acid polymers and copolymers, for example, by Hoechst under the trade designation "Hostacerin AMPS" (CTFA Designation: Ammonium Polyacryloyldimethyl Tau) rate) or poly(2-acrylamido 2-methylpropane sulfonic acid sold under the trade name "SIMULGEL 800" (CTFA designation: sodium polyacryloyldimethyl taurate/polysorbate 80/sorbitan oleate) by Seppic. ); 2-acrylamido 2-methylpropane sulfonic acid and hydroxyethyl acrylate copolymers such as SIMULGEL NS and SEPINOV EMT 10 sold by Seppic; cellulose derivatives such as hydroxyethylcellulose; polysaccharides and especially gums such as xanthan gum; hydrophilic or water-dispersible silicone derivatives such as acrylic silicones, silicone polyethers and cationic silicones and mixtures thereof.

Lipophilic thickeners include, for example, synthetic polymers, such as poly C10-C30 alkyl acrylates or modifications sold under the trade names “INTELIMER IPA 13-1” and “INTELIMER IPA 13-6” by Landdec. clay, for example hectorite and its derivatives, for example the products marketed under the name Bentone.

Obviously, the person skilled in the art will know that the additive(s) expected to enhance the advantageous properties inherently associated with the composition according to the invention, in particular the protection of the skin and/or hair and/or lips against the sun's rays, are impaired or substantially Care will be taken to select any supplemental compound(s) and/or amounts thereof mentioned above so that they are not compromised.

The composition according to the invention can be prepared according to techniques well known to the person skilled in the art. These are particularly simple or complex emulsions (O/W, W/O, O/W/O or W/O/W), for example in the form of creams, milks or cream gels; in the form of an aqueous gel; It may be in the form of a lotion. They may optionally be packaged as an aerosol and may be provided in the form of a foam or spray.

The composition according to the invention may be provided in the form of an oil-in-water or water-in-oil emulsion.

Suitable emulsification methods for use are blade or impeller, rotor-commutator and HHP types.

It is also possible to obtain stable dispersions with droplet sizes as small as 100 nm using HHP (50 to 800 bar).

Emulsions generally contain at least one emulsifying surfactant selected from amphoteric, anionic, cationic or nonionic emulsifying surfactants, used alone or in mixtures. The emulsifier is appropriately selected depending on the emulsion to be obtained (W/O or O/W).

Emulsifying surfactants suitable for use in preparing the W/O emulsions include, for example, alkyl esters or sorbitan, glycerol or sugar ethers; silicone surfactants, such as dimethicone copolyols, such as the mixture of cyclomethicone and dimethicone copolyol sold by Dow Corning under the trade designation "DC 5225 C", and alkyl-dimethicone copolyols such as laurylmethicone copolyol sold under the trade designation “Dow Corning 5200 Formulation Aid” by Dow Corning; cetyl dimethicone copolyol, for example cetyl dimethicone copolyol sold under the trade name Abil EM 90R by Goldschmidt and under the trade name ABIL WE O9 by Goldschmidt, polyglycerol isostearate (4 mole) and hexyl laurate. Advantageously, it is also possible to add one or a plurality of co-emulsifiers which may be selected from the group comprising polyol alkyl esters.

Polyol alkyl esters include, inter alia, polyethyleneglycol esters, such as PEG-30 dipolyhydroxystearate, such as those sold under the trade name Arlacel P135 by ICI.

Glycerol and/or sorbitan esters are, for example, polyglycerol isostearates, such as those sold under the trade name Isolan GI 34 by Goldschmidt; sorbitan isostearate, eg the product sold under the trade name Arlacel 987 by ICI; sorbitan isostearate and glycerol, for example the product sold under the trade name Arlacel 986 by ICI, and mixtures thereof.

For O/W emulsions, emulsifying surfactants include, for example, nonionic emulsifiers such as oxyalkylene (more specifically polyoxyethene) fatty acids and glycerol esters; oxyalkylene fatty acids and sorbitan esters; oxyalkylene (oxyethylene and/or oxypropylene) fatty acid esters, such as the PEG-100 stearate/glyceryl stearate mixture sold under the trade name Arlacel 165 by ICI; oxyalkylene (oxyethylene and/or oxypropylene) fatty alcohol ethers; sugar esters such as sucrose stearate; Fatty alcohols and sugar ethers, especially alkylpolyglucosides (APG), for example decylglucoside and laurylglucoside sold under the trade names Plantaren 2000 and Plantaren 1200 by Henkel, respectively, and Montanov 68 by Seppic , sold under the trade name Tegocare CG90 by Goldschmidt, under the trade name Emulgade KE3302 by Henkel, cetostearylglucoside optionally in a mixture with cetostearyl alcohol, and by Seppic under the trade name Montanov 202, for example , arachidyl glucoside in the form of a mixture of arachidic and behenic alcohols and arachidyl glucoside. According to one particular embodiment of the invention, the alkylpolyglucoside mixture as defined above and the corresponding fatty alcohol are in the form of a self-emulsifying composition, for example as described in document WO-A-92/06778 can be

In the case of emulsions, their aqueous phase may comprise a nonionic vesicular dispersion prepared according to known methods (Bangham, Standish and Watkins. J. Mol. Biol. 13, 238 (1965), FR 2). 315 991 and FR 2 416 008).

The composition according to the invention is particularly suitable for protecting and/or treating the skin, lips and/or hair, and/or for makeup of the skin and/or lips, including a plurality of skin, lips and/or hair, including the scalp. treatment, in particular cosmetic treatment.

The cosmetic composition according to the present invention can be used, for example, as a makeup product.

The cosmetic compositions according to the invention can be used in liquid to semi-liquid concentrations, such as milk, rather oily creams, cream gels, pastes, for example as treatment agents for the face and/or body and/or as sunscreen products. there is. They may optionally be packaged as an aerosol and may be provided in the form of a foam or spray.

The composition according to the invention in the form of a flowable lotion suitable for evaporation according to the invention is applied to the skin or hair in the form of fine particles using a pressurizing device. Devices suitable for the present invention are well known to those skilled in the art and include non-aerosol pumps or "atomizers", aerosol containers containing propellant and aerosol pumps using compressed air as propellant. The latter are described in patents US 4,077,441 and US 4,850,517 (in full part of the Detailed Description).

Aerosol-packaged compositions suitable for the present invention are generally prepared with conventional propellants, for example, the hydrofluorinated compounds dichlorodifluoromethane, difluoroethane, dimethylether, isobutane, n-butane, propane, trichlorofluoro Contains methane. They are preferably present in an amount ranging from 15 to 50% by weight, based on the total weight of the composition.

Aerosol-packaged compositions suitable for the present invention are generally prepared with conventional propellants, for example, the hydrofluorinated compounds dichlorodifluoromethane, difluoroethane, dimethylether, isobutane, n-butane, propane, trichlorofluoro Contains methane. They are preferably present in an amount ranging from 15 to 50% by weight, based on the total weight of the composition.

1 shows the absorption spectrum of a tested reference filter, with the x-axis being the wavelength in nanometers and the y-axis being the absorbance (Abs).
2 shows a bar graph of fluorescence (%) as a function of the tested composition.

For clarity, but not by way of limitation, examples illustrating the invention are now provided.

Further, in the examples, all percentages are by weight unless otherwise specified, temperatures are expressed in degrees Celsius unless otherwise specified, and pressures are atmospheric pressure unless otherwise specified. In the examples, the amounts of composition components are given in weight percent based on the total weight of the composition.

Example

Example 1 : Study of skin protection by the composition according to the invention under the effect of UVA

The purpose of this study is to show the protective performance against UVA stress. Baicalin was evaluated alone and in conjunction with sunscreen composition 1 comprising a UVA filtration system comprising at least one bis-resorcinyl triazine derivative according to the present invention.

sunscreen composition 1 award chemical name US INCI designation density Glyceryl Mono/Distearate / Polyethylene Glycol Stearate Mixture (100 OE) Glyceryl Stearate (and)
PEG-100 Stearate One poly dimethylsiloxane (viscosity: 350 CST) dimethicone 0,5 Polymethylene wax exhibiting a melting point of about 64°C synthetic wax One Octane-1,2 diol caprylyl glycol 0,4 Isopropyl N-lauroyl sarcosinate Isopropyl Lauroyl Sarcosinate 10 Triazine derivative (BEMT) = (2,4-bis((4-(2-ethyl-hexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl)-(1,3 ,5)-triazine) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine One 2-ethyl hexyl 2-cyano-3,3-diphenyl acrylate Octocrylene 5 4-tertthiobutyl-4'-methoxy-dibenzoylmethane Butyl Methoxydibenzoylmethane 1,5 triethanolamine triethanolamine 0,2 Phenoxy-2 Ethanol Phenoxyethanol 0,7 Microbiologically clean deionized water water 53,63 Ethylene diamine tetraacetic acid, disodium salt, 2 H2O Disodium EDTA 0,1 glycerol glycerin 6 propylene glycol propylene glycol 6 Acrylic acid/stearyl methacrylate copolymer polymerized in ethyl acetate/cyclohexane mixture Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0,25 Xanthan: Polysaccharide: glucose/mannose/glucuronic acid (40/30/30) xanthan gum 0,2 deionized water water One A1 Plant fatty acids (mainly stearic acid) stearic acid One A2 Cyclohexa dimethylsiloxane (viscosity: 8 CST) Cyclohexasiloxane 3 B1 B-B' camphorsulfonic acid in aqueous solution [1-4 divinylbenzene] terephthalylidene dicamphor sulfonic acid 0,3 B1 triethanolamine triethanolamine 0,05 B2 Non-stabilized monopotassium mono-cetyl phosphate Potassium Cetyl Phosphate One C Iso-hexadecane isohexadecane 3 D triethanolamine triethanolamine 0,17 E denatured anhydrous ethyl alcohol denatured alcohol 3

placebo composition 2 award chemical name US INCI name density Glyceryl Mono/Distearate / Polyethylene Glycol Stearate Mixture (100 OE) Glyceryl Stearate (and) PEG-100 Stearate One Poly dimethylsiloxane (viscosity: 350 CST) dimethicone 0,5 Polymethylene wax exhibiting a melting point of about 64°C synthetic wax One Octane-1,2 diol caprylyl glycol 0,4 Isopropyl N-lauroyl sarcosinate Isopropyl Lauroyl Sarcosinate 18,25 triethanolamine triethanolamine 0,2 Phenoxy-2 Ethanol Phenoxyethanol 0,7 Microbiologically clean deionized water water 53,18 Ethylene diamine tetraacetic acid, disodium salt, 2 H2O Disodium EDTA 0,1 glycerol glycerin 6 propylene glycol propylene glycol 6 Acrylic acid/stearyl methacrylate copolymer polymerized in ethyl acetate/cyclohexane mixture Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0,25 Xanthan: Polysaccharide: glucose/mannose/glucuronic acid (40/30/30) xanthan gum 0,2 deionized water water One A1 Plant fatty acids (mainly stearic acid) stearic acid One A2 Cyclohexa dimethylsiloxane (viscosity: 8 CST) Cyclohexasiloxane 3 B1 triethanolamine triethanolamine 0,05 B2 Non-stabilized monopotassium mono-cetyl phosphate Potassium Cetyl Phosphate One C Iso-hexadecane isohexadecane 3 D triethanolamine triethanolamine 0,17 E denatured anhydrous ethyl alcohol denatured alcohol 3

1.1. Methods and Protocols Under our experimental conditions, exposure of NHF (normal human fibroblasts) to UVA induces the generation of reactive oxygen species as measured using the DCFH-DA test.

The culture medium is as follows:

- 500 ml of DMEM basal medium containing glutamax 1,

- 50 ml of FCS,

- 5 ml of 250 μg/ml Fungizone Ampb B,

- 5 ml of 200 mM L-glutamine,

- 5 ml of penicillin-streptomycin

1.1.1. UVA Assessing protection against radiation conditions for

NHF cells were pretreated with active material for 24 h before exposure to UV. During exposure of the fibroblasts to UVA, the reference formula (“reference filter” composed of sunscreen composition 1) and placebo formula (placebo composition 2) were applied at a rate of 0.6 mg/cm 2 to a rough PMMA plate in the form of homogeneous and regular depositions. applied above. The plate was then placed on the culture plate. The active substance under evaluation (UVA filtration system comprising baicalin and/or at least one bis-resorcinyl triazine derivative, referred to as a reference filter) was present during sunlight stimulation. The following formulations were evaluated:

- NHF + UVA + placebo;

- NHF + UVA + placebo + baicalin;

- NHF + UVA + reference filter;

- NHF + UVA + reference filter + baicalin.

In the case of NHF cells treated with active substance, the control plate was kept shielded from light.

The absorption spectrum of the tested reference filter (UV protection composition 1) is shown in FIG. 1 . This filter contains acrylates: bis-resorcinyl triazine derivatives linked to octocrylene: TINOSORB S; and dibenzoylmethane derivatives: avobenzone; and a UVA filtration compound derived from benzylidene camphor: terephthalylidene dicamphor sulfonic acid. This reference filter is already the best filter according to the related prior art, which is considered technically difficult to improve with respect to its ability to protect the skin against UV.

1.1.2. exposure conditions

UVA was output by an Oriel solar simulator (xenon lamp, 1000 watts) equipped with a WG360/2mm filter. To obtain full UVA coverage, no UG11 visible section was used (however, it should be noted that the chromatic mirror of the solar simulator filters most of the visible range (85%)). The emitted UVA is within the wavelength range of 340 to 400 nm and thus may be referred to as long UVA.

1.1.3. DCFHDA test: UVA - induced oxidative evaluation of stress

Protection against UVA stress was assessed using the DCFH-DA test as a marker of global intracellular oxidative stress. Accordingly, it is possible to directly evaluate the negative effects of UVA on the cellular level and, in particular, the detrimental oxidative stress on the skin, hair and lips, especially the elasticity of the skin tissue, while promoting the appearance of wrinkles and causing premature aging of the skin.

The use of DCFH-DA as a marker of global intracellular oxidative stress is based on its physicochemical properties. It consists of non-polar and non-ionic molecules that can diffuse through cell membranes. Once inside the cell, DCFH-DA is hydrolyzed by intracellular esterases to a non-fluorescent compound: DCFH or 2,7-dichlorofluorescein. In the presence of reactive oxygen species (H ₂ O ₂ ; OH°), DCFH is rapidly oxidized to highly fluorescent compounds: DCF or 2,7-dichlorofluorescein.

Fibroblasts were protected from light by rinsing with PBS ⁺ and incubating in the presence of DCFH-DA [20 μM] at 37 °C for 30 min at 37 °C, optionally in the presence of 10 μM baicalin for 24 h. After removing the probe and rinsing twice, the cells were again contacted with the active substance (10 μM) in PBS+. A PMMA plate applied with petrolatum (control without filter) or reference filtration formula was deposited on top of the cells thereon. Baicalin was introduced into the culture medium at a concentration of 10 micromolar. They were then exposed to UVA (WG360 filter) at 20 J/cm 2 . The fluorescence of DCF was evaluated by fluorescence spectroscopy (excitation 480 nm; emission 530 nm) immediately upon exposure to UVA.

1.2/ result

10 μM baicalin was evaluated in the DCFH-DA test to demonstrate the following results ( FIG. 2 ):

- sunscreen composition 1 partially protects fibroblasts against UVA-induced ROS (reactive oxygen species): 23-27% protection;

- Association of baicalin with sunscreen composition 1 significantly improves the level of biological protection provided to cells in the UVA range with 50% efficacy in the case of "baicalin + reference filter" association.

In this way, these results show that due to the linkage of baicalin with a filtration system comprising a UVA filter comprising at least one bis-resorcinyl triazine derivative, the skin and/or lips and/or lips and/or against solar radiation, in particular UV or a surprisingly enhanced efficacy in protecting hair.

These results show that, under conditions and concentrations acceptable to those skilled in the art, means other than those consisting of using large amounts of UV filters, especially UVA filters, to effectively prevent premature aging of the skin and/or lips and/or hair. provides

Finally, these results show that in particular compositions for preventing and/or preventing premature aging of the skin and/or lips due to UVA radiation and protecting the skin and/or lips and/or hair against this form of radiation and free radicals, in particular A cosmetic composition is provided.

2/ Formulation Example

2.1 Formulation A chemical name EU INCI Designation density Microbiologically clean deionized water AQUA 64,23 glycerol glycerin 6 propylene glycol propylene glycol 6 Isopropyl N-lauroyl sarcosinate Isopropyl Lauroyl Sarcosinate 5 denatured anhydrous ethyl alcohol denatured alcohol 3 Iso-hexadecane isohexadecane 3 Cyclohexa dimethylsiloxane (viscosity: 8 CST) Cyclohexasiloxane 3 Triazine derivative (BEMT) = (2,4-bis((4-(2-ethyl-hexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl)-(1,3 ,5)-triazine) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine One Non-stabilized monopotassium mono-cetyl phosphate Potassium Cetyl Phosphate One Plant fatty acids (mainly stearic acid) stearic acid One Glyceryl Mono/Distearate / Polyethylene Glycol Stearate Mixture (100 OE) Glyceryl Stearate (and) PEG-100 Stearate One Polymethylene wax exhibiting a melting point of about 64°C synthetic wax One diisopropyl sebacate diisopropyl sebacate One deionized water AQUA One Phenoxy-2 Ethanol Phenoxyethanol 0,7 Poly dimethylsiloxane (viscosity: 350 CST) dimethicone 0,5 Octane-1,2 diol caprylyl glycol 0,4 Acrylic acid/stearyl methacrylate copolymer polymerized in ethyl acetate/cyclohexane mixture Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0,25 Baicalin (purity >95%) Scutellaria baicalensis root extract
Scutellaria baicalensis extract 0,2 triethanolamine triethanolamine 0,2 Xanthan: Polysaccharide: glucose/mannose/glucuronic acid (40/30/30) xanthan gum 0,2 triethanolamine triethanolamine 0,17 Ethylene diamine tetraacetic acid, disodium salt, 2 H2O Disodium EDTA 0,1 triethanolamine triethanolamine 0,05

2 .2 Formulation B chemical name EU INCI designation density Microbiologically clean deionized water AQUA 62,73 glycerol glycerin 6 propylene glycol propylene glycol 6 Isopropyl N-lauroyl sarcosinate Isopropyl Lauroyl Sarcosinate 5 denatured anhydrous ethyl alcohol denatured alcohol 3 Iso-hexadecane isohexadecane 3 Cyclohexa dimethylsiloxane (viscosity: 8 CST) Cyclohexasiloxane 3 4-tertthiobutyl-4'-methoxy-dibenzoylmethane Butyl Methoxydibenzoylmethane 1,5 Triazine derivative (BEMT) = (2,4-bis((4-(2-ethyl-hexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl)-(1,3 ,5)-triazine) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine One Non-stabilized monopotassium mono-cetyl phosphate Potassium Cetyl Phosphate One Plant fatty acids (mainly stearic acid) stearic acid One Glyceryl Mono/Distearate / Polyethylene Glycol Stearate Mixture (100 OE) Glyceryl Stearate (and) PEG-100 Stearate One Polymethylene wax exhibiting a melting point of about 64°C synthetic wax One diisopropyl sebacate diisopropyl sebacate One deionized water AQUA One Phenoxy-2 Ethanol Phenoxyethanol 0,7 Poly dimethylsiloxane (viscosity: 350 CST) dimethicone 0,5 Octane-1,2 diol caprylyl glycol 0,4 Acrylic acid/stearyl methacrylate copolymer polymerized in ethyl acetate/cyclohexane mixture Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0,25 Baicalin (purity >95%) Scutellaria baicalensis root extract
Scutellaria baicalensis extract 0,2 triethanolamine triethanolamine 0,2 Xanthan: Polysaccharide: glucose/mannose/glucuronic acid (40/30/30) xanthan gum 0,2 triethanolamine triethanolamine 0,17 Ethylene diamine tetraacetic acid, disodium salt, 2 H2O Disodium EDTA 0,1 triethanolamine triethanolamine 0,05

2 .3 Formulation C chemical name EU INCI designation density Microbiologically clean deionized water AQUA 59,23 glycerol glycerin 6 propylene glycol propylene glycol 6 Isopropyl N-lauroyl sarcosinate Isopropyl Lauroyl Sarcosinate 5 2-ethyl hexyl 2-cyano-3,3-diphenyl acrylate Octocrylene 5 denatured anhydrous ethyl alcohol denatured alcohol 3 Iso-hexadecane isohexadecane 3 Cyclohexa dimethylsiloxane (viscosity: 8 CST) Cyclohexasiloxane 3 Triazine derivative (BEMT) = (2,4-bis((4-(2-ethyl-hexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl)-(1,3 ,5)-triazine) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine One Non-stabilized monopotassium mono-cetyl phosphate Potassium Cetyl Phosphate One Plant fatty acids (mainly stearic acid) stearic acid One Glyceryl Mono/Distearate / Polyethylene Glycol Stearate Mixture (100 OE) Glyceryl Stearate (and) PEG-100 Stearate One Polymethylene wax exhibiting a melting point of about 64°C synthetic wax One diisopropyl sebacate diisopropyl sebacate One deionized water AQUA One Phenoxy-2 Ethanol Phenoxyethanol 0,7 Poly dimethylsiloxane (viscosity: 350 CST) dimethicone 0,5 Octane-1,2 diol caprylyl glycol 0,4 Acrylic acid/stearyl methacrylate copolymer polymerized in ethyl acetate/cyclohexane mixture Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0,25 Baicalin (purity >95%)
Scutellaria baicalensis root extract Scutellaria baicalensis extract 0,2 triethanolamine triethanolamine 0,2 Xanthan: Polysaccharide: glucose/mannose/glucuronic acid (40/30/30) xanthan gum 0,2 triethanolamine triethanolamine 0,17 Ethylene diamine tetraacetic acid, disodium salt, 2 H2O Disodium EDTA 0,1 triethanolamine triethanolamine 0,05

2 .4 Formulation D chemical name EU INCI designation density Microbiologically clean deionized water AQUA 63,93 glycerol glycerin 6 propylene glycol propylene glycol 6 Isopropyl N-lauroyl sarcosinate Isopropyl Lauroyl Sarcosinate 5 denatured anhydrous ethyl alcohol denatured alcohol 3 Iso-hexadecane isohexadecane 3 Cyclohexa dimethylsiloxane (viscosity: 8 CST) Cyclohexasiloxane 3 Triazine derivative (BEMT) = (2,4-bis((4-(2-ethyl-hexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl)-(1,3 ,5)-triazine) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine One Non-stabilized monopotassium mono-cetyl phosphate Potassium Cetyl Phosphate One Plant fatty acids (mainly stearic acid) stearic acid One Glyceryl Mono/Distearate / Polyethylene Glycol Stearate Mixture (100 OE) Glyceryl Stearate (and) PEG-100 Stearate One Polymethylene wax exhibiting a melting point of about 64°C synthetic wax One diisopropyl sebacate diisopropyl sebacate One deionized water AQUA One Phenoxy-2 Ethanol Phenoxyethanol 0,7 Poly dimethylsiloxane (viscosity: 350 CST) dimethicone 0,5 Octane-1,2 diol caprylyl glycol 0,4 B-B'camphorsulfonic acid in aqueous solution [1-4 divinylbenzene] terephthalylidene dicamphor sulfonic acid 0,3 Acrylic acid/stearyl methacrylate copolymer polymerized in ethyl acetate/cyclohexane mixture Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0,25 Baicalin (purity >95%)
Scutellaria baicalensis root extract Scutellaria baicalensis extract 0,2 triethanolamine triethanolamine 0,2 Xanthan: Polysaccharide: glucose/mannose/glucuronic acid (40/30/30) xanthan gum 0,2 triethanolamine triethanolamine 0,17 Ethylene diamine tetraacetic acid, disodium salt, 2 H2O Disodium EDTA 0,1 triethanolamine triethanolamine 0,05

2 .5 Formulation E chemical name EU INCI designation density Microbiologically clean deionized water AQUA 62,43 glycerol glycerin 6 propylene glycol propylene glycol 6 Isopropyl N-lauroyl sarcosinate Isopropyl Lauroyl Sarcosinate 5 denatured anhydrous ethyl alcohol denatured alcohol 3 Iso-hexadecane isohexadecane 3 Cyclohexa dimethylsiloxane (viscosity: 8 CST) Cyclohexasiloxane 3 4-tertthiobutyl-4'-methoxy-dibenzoylmethane Butyl Methoxydibenzoylmethane 1,5 Triazine derivative (BEMT) = (2,4-bis((4-(2-ethyl-hexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl)-(1,3 ,5)-triazine) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine One Non-stabilized monopotassium mono-cetyl phosphate Potassium Cetyl Phosphate One Plant fatty acids (mainly stearic acid) stearic acid One Glyceryl Mono/Distearate / Polyethylene Glycol Stearate Mixture (100 OE) Glyceryl Stearate (and) PEG-100 Stearate One Polymethylene wax exhibiting a melting point of about 64°C synthetic wax One diisopropyl sebacate diisopropyl sebacate One deionized water AQUA One Phenoxy-2 Ethanol Phenoxyethanol 0,7 Poly dimethylsiloxane (viscosity: 350 CST) dimethicone 0,5 Octane-1,2 diol caprylyl glycol 0,4 B-B'camphorsulfonic acid in aqueous solution [1-4 divinylbenzene] terephthalylidene dicamphor sulfonic acid 0,3 Acrylic acid/stearyl methacrylate copolymer polymerized in ethyl acetate/cyclohexane mixture Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0,25 Baicalin (Purity >95%) Scutellaria baicalensis Root Extract Scutellaria baicalensis extract 0,2 triethanolamine triethanolamine 0,2 Xanthan: Polysaccharide: glucose/mannose/glucuronic acid (40/30/30) xanthan gum 0,2 triethanolamine triethanolamine 0,17 Ethylene diamine tetraacetic acid, disodium salt, 2 H2O Disodium EDTA 0,1 triethanolamine triethanolamine 0,05

Claims (13)

A topical cosmetic composition having photoprotective properties against UVA, comprising:
baicalin or a plant extract containing baicalin, and
at least one UVA radiation filtration system
including,
The UVA radiation filtration system,
- at least one bis-resorcinyl triazine derivative, said bis-resorcinyl triazine derivative comprising
2,4-bis{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxy-phenyl)-1,3,5-triazine; 2,4-bis{[4-tris(trimethylsiloxy-silylpropyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine; 2,4-bis{[4-(1',1',1',3',5',5',5'-heptamethyltrisiloxy-2"-methylpropyloxy)-2-hydroxy] -phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine and bis-ethylhexyloxyphenol methoxyphenyl triazine, or
at least one bis-resorcinyl triazine derivative, which is bis-ethylhexyloxyphenol methoxyphenyl triazine, and
- a UVA filtering compound from benzylidene camphor, said benzylidene camphor
3-benzylidene camphor,
4-methylbenzylidene camphor,
benzylidene camphor sulfonic acid,
camphor benzalkonium methosulfate,
polyacrylamidomethyl benzylidene camphor, and
terephthalylidene dicamphor sulfonic acid
UVA filtration compound derived from benzylidene camphor, selected from the group consisting of
A composition comprising a. According to claim 1,
Further comprising a dibenzoylmethane derivative,
The dibenzoylmethane derivative is,
- 2-methyldibenzoylmethane,
- 4-methyldibenzoylmethane,
- 4-isopropyldibenzoylmethane,
- 4-tert-butyldibenzoylmethane,
- 2,4-dimethyldibenzoylmethane;
- 2,5-dimethyldibenzoylmethane;
- 4,4'-diisopropyldibenzoylmethane,
- 4,4'-dimethoxydibenzoylmethane,
- 4-tert-butyl-4'-methoxydibenzoylmethane,
- 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane,
- 2-methyl-5-tert-butyl-4'-methoxydibenzoylmethane,
- 2,4-dimethyl-4'-methoxydibenzoylmethane,
- 2,6-dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane
Composition, characterized in that selected from the group consisting of. According to claim 1,
A composition, characterized in that it further comprises at least one UVB filter comprising a compound having β,β′-diphenylacrylate. 4. The method of claim 3,
The β,β'-diphenyl acrylate compound having a composition, characterized in that the octocrylene. According to claim 1,
wherein said UVA radiation filtration system comprises at least bis-ethylhexylphenol methoxyphenyltriazine, avobenzone and terephthalylidene dicamphor sulfonic acid, wherein said composition further comprises octocrylene composition to do. According to claim 1,
A composition, characterized in that it further comprises a cosmetically acceptable excipient. comprising separately packaged composition A and composition B;
said composition A comprises at least baicalin or a plant extract containing baicalin in a cosmetically acceptable medium;
wherein composition B comprises at least one UVA radiation filtration system in a cosmetically acceptable medium;
The UVA radiation filtration system,
- at least one bis-resorcinyl triazine derivative, said bis-resorcinyl triazine derivative comprising
2,4-bis{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxy-phenyl)-1,3,5-triazine; 2,4-bis{[4-tris(trimethylsiloxy-silylpropyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine; 2,4-bis{[4-(1',1',1',3',5',5',5'-heptamethyltrisiloxy-2"-methylpropyloxy)-2-hydroxy] -phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine and bis-ethylhexyloxyphenol methoxyphenyl triazine, or
at least one bis-resorcinyl triazine derivative, which is bis-ethylhexyloxyphenol methoxyphenyl triazine, and
- a UVA filtering compound derived from benzylidene camphor, wherein the benzylidene camphor is
3-benzylidene camphor,
4-methylbenzylidene camphor,
benzylidene camphor sulfonic acid,
camphor benzalkonium methosulfate,
polyacrylamidomethyl benzylidene camphor, and
terephthalylidene dicamphor sulfonic acid
UVA filtration compound derived from benzylidene camphor, selected from the group consisting of
comprising;
A multi-component preparation for photoprotection against UVA of human keratin materials (skin, lips, hair, eyelashes, eyebrows, nails), wherein said composition A and said composition B are applied simultaneously or sequentially onto the surface of the keratinous material. 8. The method of claim 7,
A multi-component formulation wherein application of composition A and application of composition B are sequential, wherein composition A comprising baicalin is applied first. 9. The method of claim 8,
the time interval between application of A and B varies from 1 hour to 48 hours, or from 1 hour to 24 hours; A multi-component formulation, wherein filtration composition B is suitably applied immediately prior to exposure to UV or solar radiation. 7. The method according to any one of claims 1 to 6,
The composition is a composition for preventing or preventing photo-induced premature aging of the skin and/or lips and/or hair by topical application to the skin and/or lips and/or hair, or
Composition according to claim 1, wherein said composition is a composition for protecting the skin and/or lips and/or hair against solar radiation by topical application to the skin and/or lips and/or hair. 10. The method according to any one of claims 7 to 9,
wherein said multi-component formulation is a multi-component formulation for preventing or preventing photo-induced premature aging of the skin and/or lips and/or hair by topical application to the skin and/or lips and/or hair; , or
Multi-component formulation, characterized in that the multi-component formulation is a multi-component formulation for protecting the skin and/or lips and/or hair against solar radiation by topical application to the skin and/or lips and/or hair. -Ingredient formulations. delete delete

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