CN101780217B - TCM implant for treating haemorrhoids and preparation method thereof - Google Patents
TCM implant for treating haemorrhoids and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine implant for treating haemorrhoids and a preparation method thereof. The implant comprises the following components by weight part: 3 to 10 parts of smoked plum extract, 2 to 6 parts of rheum officinale extract and 1 to 3 parts of bletilla mucilage. The preparation method thereof comprises the following steps: weighing smoked plum extract, rheum officinale extract and bletilla mucilage powder by the weight ratio of the components; adding water to swell the components; evenly mixing the components; drying at 60 to 85 DEG C into the semisolid body; adding to an elongated (alternatively cylindrical or bullet-shaped) implant mold with the length of the implant mold being 3mm to 15mm and the maximum diameter thereof being 0.5mm to 2.0mm, and carrying out the compression-molding process; drying the implant mold added with a drug at 50 to 70 DEG C for 1h to 5h; and taking out the drug to obtain the TCM implant of the invention for treating haemorrhoids.
Description
Technical field
The present invention relates to a kind of Chinese medicine and production method thereof that is used to treat symptoms such as the hemorrhoid disease is hemorrhage, prolapsus, particularly a kind of is the Chinese medicine implant and the production method thereof of raw material for treating hemorrhoid with the Chinese medicine.
Background technology
Hemorrhoid are a kind of commonly encountered diseases, frequently-occurring disease.Nineteen seventies is the modern notion that the scholar of representative has proposed hemorrhoid with United States Medical Doctor Thomason etc.; Pointed out that the sick essence of hemorrhoid is that the pathologic of anus pad is loose, thought that the anus pad is made up of ATZ epithelium, hemorrhoid district arteriovenous anastomosis (claiming hole shape vein again) and network frame supporting structure Treitz flesh etc.Scholars such as Thomason think that arteriovenous anastomosis is the blood volume actuator of anus pad, regulated by factors such as nerve, vaso-active substance.Treitz flesh is the network and the supporting structure of anus pad, and it has fixedly anus pad, restriction hole shape venectasia, make the regressive effect of anus pad behind the defecation.If Treitz muscle relaxation or fracture, anus pad can occur replying obstacle and be shifted, hole shape venous network constraint effect is also just weakened or out of control.The anus pad activates venous anastomosis generation blood volume insufficiency of accommodation under other factors stimulates in addition; And anastomotic vessel expansion, blood stasis, tissue edema, blood clot are formed; Microcirculation disturbance takes place cause local necrosis at last; Rotten to the corn hemorrhage, it is congested loose and symptom such as have blood in stool, deviate from and be the hemorrhoid diseases to produce anus pad pathologic.Though the sick cause of disease of definite hemorrhoid is unclear as yet, the still anus pad of generally acknowledging at present moves down theory and circulatory disturbance theory.
Anorectal bound pair treatment of hemorrhoid is being carried out research always and is being inquired into and accumulating rich experience both at home and abroad; Formulated fumigation and wash method, guided, applied ointment or plaster, tens of kinds of Therapeutic Method such as acupuncture, withered hemorrhoid, ligation, freezing, laser, injection, excision, PPH art, electronics treatment, developed thousands of active drugs.Traditional injection treatment since be with medicine be injected in the venous plexus that its blood stasis is expanded collapse close, atrophy or necrosis come off; So its effect than fumigation and wash method, acupuncture, apply ointment or plaster, treatment such as electronic therapeutic instrument internal hemorrhoid better efficacy; Than the safer easy few side effects of operation; There are not the misery of operative treatment, complication such as hemorrhage, narrow again, so pushed away first-selected conservative treatment by industry always into the treatment internal hemorrhoid.
Aspect injection treatment, adopt the history in existing more than 100 year of injection treatment treatment internal hemorrhoid abroad.The medicine that is used to inject internal hemorrhoid successively has copperas solution, 1: 2 phenol olive oil, 5-7% phenol glycerol etc.; But fine anatomical structure of some rectum anal tubes and anus pad have inevitably been destroyed more or less; Damage the rectum anal tube function in various degree, produced untoward reaction and complication such as pain, infection, hemorrhage, anal stenosis.So abroad this has dropped on the back of China on the one hand in the injection for curing hemorrhoid.At home; From the Tang Dynasty;---evolution process of withered hemorrhoid nail---" Kuzhi " liquid---hardening bath four-stage, development have formed downright bad injection treatment and sclerosis injection treatment two big systems so far and have stepped the step of having gone up the softening agent injection treatment successively through Kuzhi San.The outstanding representative of current downright bad agent injection treatment is " new No. six injection " that grind director Li Yunong of institute initiative in the Chongqing, but if improper use can have complication generations such as massive hemorrhage; " XIAOZHILING ZHUSHEYE " of first-elected director Shi Zhaoqi of the Guang-amen Hospital, China Traditional Chinese Medicine Instl development of sclerosing agent injection therapy; Because complicated operation, the patient is if grasping improper meeting affects the treatment, even complication such as severe bleeding, anal stenosis; Institute's medicament contains harmful aluminium ion and is stranded in the part in addition; Coagulated protein makes surrounding tissue form foreign body collagen fiber cicatrixization, and it then is its deficiency that the normal anatomical structures and the partial function of anus pad caused irreversible infringement etc." the Chinese herbaceous peony times injection " of Beijing China-Japan Friendship Hospital An A Yue professor development overcomes these deficiencies and takes the lead in adopting softening injection for treating internal hemorrhoid, obtained good curative effect.
Domestic and international at present research China to implant occupy the leading position, is mainly used in the treatment of chronic disease, ocular disease and anti-addiction such as contraception, antitumor, insulin administration, cardiovascular disease, prostatosis, endometrial disease, chronic sinusitis, pulmonary tuberculosis.Adopt the Chinese medicine implant that hemorrhoid are treated domestic and international at present still blank.
Summary of the invention
The purpose of this invention is to provide that a kind of what be used to treat symptoms such as the hemorrhoid disease is hemorrhage, prolapsus is the Chinese medicine implant of raw material with the Chinese medicine.
The Chinese medicine implant and the production method thereof of treatment hemorrhoid provided by the invention have reached the foregoing invention purpose, and the component of the Chinese medicine implant of treatment hemorrhoid and the weight portion of each component are following:
Fructus Mume extract 3-10
Radix Et Rhizoma Rhei extract 2-6
Pseudobulbus Bletillae (Rhizoma Bletillae) glue 1-3,
Wherein, Fructus Mume extract is for adopting water or potass extraction, and the dry thing that ethanol precipitate with ethanol or ion-exchange resin purification are processed, Radix Et Rhizoma Rhei extract are to adopt ethanol extraction; The dry thing that the nonpolar macroporous adsorption resin purification is processed, Pseudobulbus Bletillae (Rhizoma Bletillae) glue are the cotton-shaped colloid that the Pseudobulbus Bletillae (Rhizoma Bletillae) makes through aqueous extraction-alcohol precipitation technology.
The production method of the Chinese medicine implant of treatment hemorrhoid is following:
(1) gets the raw materials ready according to the said components part by weight;
(2) according to the said components part by weight, take by weighing Radix Et Rhizoma Rhei and Fructus Mume extract fine powder and Pseudobulbus Bletillae (Rhizoma Bletillae) glue and mixing, add 0.5-3 times of water of medicated powder weight; Mix well after making the medicated powder swelling, place the drying under reduced pressure case, 60-85 ℃ of dry 0.5-4h takes out the semi-solid medicine; Insert compression moulding in the implant mould; The implant mould that adds medicine in 50-70 ℃ of dry 1-5h, is taken out medicine, promptly get the Chinese medicine implant of treatment hemorrhoid of the present invention.
Said mould is the strip mould of one of the bullet shaped of length 3-15mm, diameter or bottom surface diagonal 0.5-2.0mm, cylindrical, triangular taper or multi-edge column-shaped.
The Chinese medicine implant of treatment hemorrhoid is on the basis of Qing Dynasty ancient prescription Fructus Mume Rhizoma Coptidis two flavor balls, to combine individual clinical experience initiative to form, and clinical efficacy is definite.Disposable medication cure rate reaches 98% in 200 examples of systematic observation.For the new Chinese medicine of the disposable medication of locality is implanted dosage form; Implanting in the blood stasis lets its slow release local action to reach the purpose of controlling hemorrhoid; Thereby the mechanism that traditional withered hemorrhoid nail is come off by the necrosis of inserting becomes the hemorrhoid atrophy that disappears of implantation; Overcome the downright bad massive hemorrhage that comes off, easy infection damage anus pad and medicine nail and exposed the deficiency of damage normal structure, and kept the accurate positioning of traditional withered hemorrhoid nail, persistent, the advantage that late result is good.
The Chinese medicine implant of treatment hemorrhoid is combined by the effective site of Fructus Mume, Radix Et Rhizoma Rhei medicine in proportion.The effective ingredient of Fructus Mume, Radix Et Rhizoma Rhei is clear, and the mechanism of action is clear and definite, adopts modern extraction process to extract the technology maturation of Fructus Mume, Radix Et Rhizoma Rhei effective site respectively.The adjuvant of this implant is for not only having astringing to arrest bleeding effect but also biodegradable Pseudobulbus Bletillae (Rhizoma Bletillae) glue.
At present also do not record the Chinese medicine implant in China's pharmacopeia, so the present invention treats preparation process and the blank that dosage form has been filled up domestic and international this research field and new drug development of the Chinese medicine implant of hemorrhoid.
The present invention selects for use Fructus Mume acid to hold back the arresting collape syndrome by astringents hemostasis, strengthens the supporting structure of anus pad, makes it adhesion and fixes; Use the Radix Et Rhizoma Rhei blood circulation promoting and blood stasis dispelling, regulate blood volume and local metabolism, improve oxygen supply and remove metabolite; Thereby improve the microcirculation disturbance in the anus pad, make it restore to the normal physiological state and stop blooding, and do not contain harmful aluminium ion; Easy to use, directly implant under the hemorrhoid district mucosa and get final product.Therefore, the Chinese medicine implant that uses the present invention to treat hemorrhoid can be avoided complication such as massive hemorrhage, anal stenosis, is a kind of medicine of novel, effective, safe treatment hemorrhoid.
Description of drawings
Fig. 1 bullet shaped implant profile sketch map
The cylindrical implant profile of Fig. 2 sketch map
The triangular taper implant of Fig. 3 profile sketch map
Fig. 4 multi-edge column-shaped implant profile sketch map
The specific embodiment
Embodiment 1
The production stage of the Chinese medicine implant of treatment hemorrhoid is following:
(1) get the raw materials ready according to the part by weight in the following prescription:
Fructus Mume extract 3kg
Radix Et Rhizoma Rhei extract 2kg
Pseudobulbus Bletillae (Rhizoma Bletillae) glue 1kg
(2) according to the said components part by weight, take by weighing Radix Et Rhizoma Rhei extract, Fructus Mume extract and Pseudobulbus Bletillae (Rhizoma Bletillae) glue fine powder, mix well after adding water 3kg swelling, place the drying under reduced pressure case; 60 ℃ of temperature, 0.5h becomes semi-solid to take out, and adds in the cylinder awl property implant mould; Compression moulding, the long 3mm of mould, column part diameter 0.5mm, 50 ℃ of temperature; Time 1h takes out the Chinese medicine implant of bullet shaped treatment hemorrhoid, and is as shown in Figure 1.
Raw material among other embodiment is produced all identical with present embodiment.
Embodiment 2
The production stage of the Chinese medicine implant of treatment hemorrhoid is following:
(1) get the raw materials ready according to the part by weight in the following prescription:
Fructus Mume extract 10kg
Radix Et Rhizoma Rhei extract 6kg
Pseudobulbus Bletillae (Rhizoma Bletillae) glue 3kg
(2) according to the said components part by weight, take by weighing Radix Et Rhizoma Rhei and Fructus Mume extract fine powder and Pseudobulbus Bletillae (Rhizoma Bletillae) glue and mixing, add the water of 16kg; Mix well after making the medicated powder swelling, place the drying under reduced pressure case, 70 ℃ of dry 2h; Take out the semi-solid medicine, add compression moulding in the cylindrical implant mould, the long 10mm of mould; Body diameter 1.5mm takes out the Chinese medicine implant that cylindrical strip is treated hemorrhoid behind 60 ℃ of dry 2h, and is as shown in Figure 2.
Embodiment 3
The production stage of the Chinese medicine implant of treatment hemorrhoid is following:
(1) get the raw materials ready according to the part by weight in the following prescription:
Fructus Mume extract 6kg
Radix Et Rhizoma Rhei extract 3kg
Pseudobulbus Bletillae (Rhizoma Bletillae) glue 2kg
(2) according to the said components part by weight, take by weighing Radix Et Rhizoma Rhei and Fructus Mume extract fine powder and Pseudobulbus Bletillae (Rhizoma Bletillae) glue and mixing, add 33kg water; Mix well after making the medicated powder swelling, place the drying under reduced pressure case, 85 ℃ of dry 4h; Take out the semi-solid medicine, add compression moulding in the triangular pyramid implant mould, the long 8mm of mould; Take out the Chinese medicine implant of triangular taper treatment hemorrhoid behind the long 0.5mm of long-diagonal in bottom surface, 70 ℃ of dry 5h.
Embodiment 4
The production stage of the Chinese medicine implant of treatment hemorrhoid is following:
(1) get the raw materials ready according to the part by weight in the following prescription:
Fructus Mume extract 8kg
Radix Et Rhizoma Rhei extract 3kg
Pseudobulbus Bletillae (Rhizoma Bletillae) glue 3kg
(2) according to the said components part by weight, take by weighing Radix Et Rhizoma Rhei and Fructus Mume extract fine powder and Pseudobulbus Bletillae (Rhizoma Bletillae) glue and mixing, add medicated powder weight 24kg water; Mix well after making the medicated powder swelling, place the drying under reduced pressure case, 75 ℃ of dry 3h take out the semi-solid medicine; Add compression moulding in the multi-edge column-shaped implant mould, the long 15mm of mould, the long 2mm of long-diagonal in bottom surface; Take out the Chinese medicine multi-edge column-shaped implant of treating hemorrhoid behind 65 ℃ of dry 4h, as shown in Figure 4.
Embodiment 5
The production stage of the Chinese medicine implant of treatment hemorrhoid is following:
(1) get the raw materials ready according to the part by weight in the following prescription:
Fructus Mume extract 6kg
Radix Et Rhizoma Rhei extract 2kg
Pseudobulbus Bletillae (Rhizoma Bletillae) glue 1.5kg
(2) according to the said components part by weight, take by weighing Radix Et Rhizoma Rhei and Fructus Mume extract fine powder and Pseudobulbus Bletillae (Rhizoma Bletillae) glue and mixing, add medicated powder weight 18kg water; Mix well after making the medicated powder swelling, place the drying under reduced pressure case, 85 ℃ of dry 2h take out the semi-solid medicine; Add compression moulding in the cylindrical implant mould; The long 12mm of mould takes out the Chinese medicine implant of cylindrical treatment hemorrhoid behind the diameter 2mm, 60 ℃ of dry 5h.
Utilize the treatment case of the Chinese medicine implant of treatment hemorrhoid of the present invention
Case 1
The patient, the man, 34 years old, because of go to a doctor " archorrhagia is 1 month when defecating repeatedly ".The patient tell treat with courtesy nearly January more, when defecating after drinking anus flow out blood in addition spurting hemorrhage, do not accompany proctalgia.It is dried partially sometimes to defecate, generally speaking the soft easy row of matter.
Deny chronic, major disease medical histories such as hypertension, diabetes.Deny medicine and food anaphylaxis history.
Have a medical check-up: the anus position is placed in the middle, and outward appearance is no abnormal, sees the mucous hyperemia swelling of hemorrhoid district under the anoscope, and active hemorrhage is not seen in 3,5,7,11 hemorrhoid district mucosal erosions of lithotomy position.Refer to examine fingerstall and stain with blood on a small quantity, scarlet.
Diagnosis: II phase internal hemorrhoid
Dispose: the patient gets left lateral position, routine disinfection crissum, anus, anorectal region hypomere.Under anoscope, use the implantation utensil that implant is implanted under the pathological changes internal hemorrhoid mucosa.Hemostasis is pushed in sterilization, withdraws from anoscope.The processing of changing dressings of end of operation, routine.
Pay a return visit: disposing does not have obviously hemorrhagely when the back began to defecate on the 3rd day, do not accompany anus uncomfortable.Dispose capable anoscopy in back 14 days and see that hemorrhoid district mucosa does not have obvious congested swelling, does not see erosion.
Case 2
The patient, the man, 44 years old, because of " 3 years surplus increasing the weight of for 2 weeks of archorrhagia when defecating repeatedly " goes to a doctor.It is hemorrhage that the patient tells often when defecate in the take food maror and the back of drinking, drip blood or spurting, and personal medicines such as " MAYINGLONG MUSK HEMORRHOID UNGUENTUM, Ma Yinglong Moschus ZHICHUAN SHUAN, Jiuhua Zhichuang Shuan, ZHIGENDUAN " can be alleviated.Drank before 2 weeks and the chaffy dish of taking food after during every stool spurting hemorrhage, personal aforementioned medicine does not have positive effect, satisfies and comes my section to go to a doctor.Matter soft easy row in the recent period defecates.
Deny operation, wound, blood transfusion history.Deny that other is chronic, the major disease medical history.Deny medicine and food anaphylaxis history.
Have a medical check-up: the anus position is placed in the middle, and outward appearance is no abnormal.Anoscopy sees that hemorrhoid district mucosa swelling knuckle is obvious, 3,7,11 coarse companion's varicosis of mucomembranous surface fibrosis, touch lay one's hand on and a plurality of loose knuckle agglomerates in hemorrhoid district closely adjacent, matter is soft, there is scleroma the part.
Diagnosis: III phase internal hemorrhoid
Dispose: the patient gets RAR, routine disinfection crissum, anus, anorectal region hypomere.Under anoscope, use and implant utensil under 3,5,6,7,9,11 hemorrhoid district mucosas of implant implantation.Hemostasis is pushed in sterilization, withdraws from anoscope.Give ciprofloxacin sheet 0.5g po.bid * 3d.
Pay a return visit: postoperative 7 days patients pay a return visit, the anus smooth in appearance, and the row anoscopy sees that hemorrhoid district mucosa does not have hyperemia, erosion, 3,7,9,11 summary projections refer to that inspection is laid one's hand on and there is little scleroma in 11 hemorrhoid districts.
Case 3
The patient, the man, 62 years old, because of " anus has thing to deviate to accompany hemorrhage 2 years when defecating repeatedly " goes to a doctor.The patient tells and began constipation with dry stool, difficult defecation in the pungent back of feed repeatedly before 2 years, accompanies the blood that drips, and several anus has thing to deviate from the time of just to ten droplet satellite, does not have obvious proctalgia, humidity etc., even pruritus ani.
The patient has " 3 grades of hypertension are high-risk " medical history 4 years, and personal at present Nifedipine sustained release tablets 10mg po.Bid controlling blood pressure is basicly stable at 120-140/70-90mmHg.Deny other chronic disease medical history.Deny thing and food anaphylaxis history.
Have a medical check-up: the anus position is placed in the middle, 3,7,11 anus edge skin hyperplasias of lithotomy position knuckle.See hemorrhoid district mucous hyperemia under the anoscope, 3,7,11 hemorrhoid district mucosa swelling protuberances.3,7,11 mucocutaneous up and down linking to each other of each corresponding tooth trace are integrally formed.Referring to that the inspection fingerstall does not have stains.
Diagnosis: mixed hemorrhoid
3 grades of hypertension are high-risk
Dispose: the patient gets lithotomy position, routine disinfection crissum, anus, anorectal region hypomere under sacral block.Under anoscope, use and implant utensil with under 3,7,11 hemorrhoid district mucosas of implant implantation, hemostasis is pushed in sterilization, withdraws from anoscope.Row " art is pricked in the external hemorrhoid stripping ".Postoperative gives conventional antibiotic prophylaxis and infects, and sets upright the pill for smoothing intestines loosening bowel to relieve constipation.Whenever sterilization is changed dressings greatly after an action of the bowels.
Pay a return visit: postoperative 21 days patients pay a return visit, the anus smooth in appearance, and the row anoscopy sees that hemorrhoid district mucosa does not have obvious congested swelling, does not see erosion.
Case 4
The patient, the man, 39 years old, because of " the swollen beyond the region of objective existence of stool band blood anus takes off and increased the weight of to accompany the pain first quarter moon in the 2 years " operation of being in hospital.The patient tells archorrhagia when no obvious inducement is defecated before 2 years, is spurting, and color is scarlet, and blood ends after an action of the bowels.Can lay one's hand on and anus has a swollen beyond the region of objective existence to take off, can return voluntarily after an action of the bowels and receive in the anus.Do not accompany proctalgia, tenesmus.Patient's diagnosis and treatment of not seeking medical advice.Stool band blood idol has generation, swollen beyond the region of objective existence to take off then outbreak often of symptom afterwards.Swollen beyond the region of objective existence takes off that situation is more preceding obviously to be increased the weight of before the first quarter moon, and can not return and receive in the anus, and uncomfortable with pain.Prescription on individual diagnosis gives oral drugs, anus medicine-feeding treatment (specifically not quite clear) to the outer court, imitates not good.Go to a doctor to my section's outpatient service again, patient diagnosis is for " mixed hemorrhoid " and take in institute.When being admitted to hospital ordinary circumstance can, food receive can, stool 2-3 day delegation, the soft shaping of matter, urine is transferred, it is good to sleep.Body weight is not seen obviously and is alleviated.
Previously body is strong.Deny that hepatitis, tuberculosis etc. infect medical history.Deny the history of transfusing blood.Deny great trauma history.Before 2 years in the outer court operative treatment eyes myopia, concrete condition is not quite clear.Deny the chronic medical histories of internal medicine such as diabetes, hypertension.Aminophenazone, Fructus Mangifera Indicae, soil lacquer allergies.
Have a medical check-up: lithotomy position.Inspection: the anus position is placed in the middle.Anus edge one all connective tissue proliferation protuberances are obvious with anus right side and front side especially.Anoscopy: the mucous hyperemia swelling of hemorrhoid district, part is rotten to the corn, and is obvious with 3,7,11 especially, and tooth trace is mucocutaneous up and down to be merged mutually, becomes one, and tooth trace partly disappears.Refer to inspection: do not lay one's hand on and unusual enclosed mass, fingerstall does not have and stains.
Diagnosis: ring-shaped mixed hemorrhoids
Dispose: the patient gets lithotomy position, routine disinfection crissum, anus, anorectal region hypomere under narcotism.Under anoscope, use and implant utensil under 3,6,7,11 hemorrhoid district mucosas of implant implantation.Hemostasis is pushed in sterilization, withdraws from anoscope.The wing joint-cutting art of row mixed hemorrhoid.Postoperative gives conventional antibiotic prophylaxis and infects, and whenever sterilization is changed dressings greatly after an action of the bowels.
Pay a return visit: postoperative 21 days patients pay a return visit, the anus smooth in appearance, and the row anoscopy sees that hemorrhoid district mucosa does not have obvious congested swelling, does not see erosion.
Case 5
The patient, the woman, 71 years old, because of " 7 years proctalgias of stool band blood 2 years surplus " repeatedly hospitalization.The patient tells the blood that drips when unknown cause is defecated before 7 years, does not accompany proctalgia, and the patient does not give attention.Patient's unknown cause proctalgia repeatedly before 2 years, the diagnosis and treatment suggestion operative treatment in the outer court, the patient does not perform the operation, and section goes to a doctor to my, takes a turn for the better after giving Chinese medicine fumigation and washing, dressing change.Today, the patient came my section to require the operative treatment of being in hospital, and outpatient service is satisfied with " mixed hemorrhoid " income in hospital.When being admitted to hospital ordinary circumstance can, anorexia, it is poor to sleep, and defecates 1 time/day, shapeless when being formed with sometimes, do not see hemorrhage, frequent micturition, dysuria, no gross hematuria.
Deny that hepatitis, tuberculosis etc. infect medical history.Deny the history of transfusing blood.Deny great trauma history and history of operation.The patient has surplus the chronic bronchitis history 10 year; Year all sees leukocyte in the prolonged and repeated inspection routine urinalysis, occults blood surplus the chronic pyelonephritis medical history 10, existing not medication treatment; Pareordia dull pain 8 years is surplus repeatedly, and row 24 hr Ambulatory EKG Monitoring are diagnosed as " arrhythmia " in the outer court before 2 years, can alleviate recent less outbreak from obeying 10 of Radix Salviae Miltiorrhizae drop pills during outbreak; Chronic superficial gastritis medical history 7 years is surplus; Migraine medical history 6 years is surplus; Chronic cystitis medical history 3 years; Chronic colitis medical history 1 year is surplus.Levofloxacin injection allergies.History of preventive inoculation is not quite clear.Have a medical check-up: lithotomy position.Anus moves behind the position.Anus edge one all connective tissue proliferation knuckles.The mucous hyperemia swelling of hemorrhoid district, especially obviously with 3,5,7,11.3 and 11 visible subcutaneous atropurpureus agglomerates of anus edge.There is the about 0.1cm of 1 papillary hyperplasia projection at 7 tooth trace places.Mucocutaneous up and down linking to each other of tooth trace is integrally formed, and the tooth trace ditch partly disappears.Refer to that inspection hemorrhoid district is soft swollen prominent, do not lay one's hand on and lump etc.
Diagnosis: ring-shaped mixed hemorrhoids
Chronic colitis
Coronary atherosclerotic heart disease
Chronic superficial gastritis
Chronic pyelonephritis
Chronic cystitis
Chronic bronchitis
Migraine
Dispose: the patient gets lithotomy position, routine disinfection crissum, anus, anorectal region hypomere under narcotism.Under anoscope, use and implant utensil under 3,5,7,11 hemorrhoid district mucosas of implant implantation.Hemostasis is pushed in sterilization, withdraws from anoscope.6 positions of little curved hemostatic forceps clamp external hemorrhoid skin, wing incision external hemorrhoid skin divests cirso-, hypertrophy connective tissue and thrombosis, and the both sides otch is interrupted suture 2 pins respectively, middle curved hemostatic forceps clamp hemorrhoid root, No. 7 silk threads " 8 " word seam is pricked.Handle 7,11 external hemorrhoids with method.Expand anus.3 positions of little curved hemostatic forceps clamp external hemorrhoid skin, fusiformis is cut external hemorrhoid skin, divests cirso-, hypertrophy connective tissue and thrombosis, middle curved hemostatic forceps clamp hemorrhoid root, No. 7 silk threads " 8 " word seam is pricked.In 3 position otch interrupted suture 2 pins hemostasis.Postoperative gives conventional antibiotic prophylaxis and infects, and whenever sterilization is changed dressings greatly after an action of the bowels.
Pay a return visit: postoperative 21 days patients pay a return visit, the anus smooth in appearance, and 11 hemorrhoid district mucosa mild hyperaemias are seen in the row anoscopy, no edema is rotten to the corn.
Case 6
The patient, the woman, 15 years old, because of " stool bleed the swollen beyond the region of objective existence of anus took off 2 months " hospitalization.The patient tells the blood that drips when beginning the every stool of not clear inducement before 2 months, and amount is many as menstrual onset, and companion's proctalgia, anus have the beyond the region of objective existence that swells to take off, and can return voluntarily after an action of the bowels and receive in the anus.Proctalgia is alleviated gradually after an action of the bowels.Underwear is not seen bloodstain at ordinary times.Stool is shaped, and difficult defecation need be obeyed Fructus Cannabis Bolus sometimes certainly to help defecation.The patient goes to a doctor to province institute of traditional Chinese medicine, gives medicine anus medicine-feeding treatment (specifically not quite clear), and amount of bleeding reduces slightly, still has thing to deviate from during stool.Modern to my section's outpatient service prescription on individual diagnosis, patient diagnosis is for " anal papilla tumor, mixed hemorrhoid, anal fissure " and take in institute.When being admitted to hospital ordinary circumstance can, receive sleep can, stool delegation's every day does partially, the urine accent.
Deny that hepatitis, tuberculosis etc. infect medical history.Deny the history of transfusing blood.Deny great trauma history.Performed the operation in the outer court because of the eyes trichiasis before 4 years, concrete condition is not quite clear.Deny chronic, major disease medical histories such as diabetes, hypertension, asthma.Deny medicine and food anaphylaxis history.
Have a medical check-up: lithotomy position.The anus position is placed in the middle.Clockwise 10-1,2,3-9 point anus edge connective tissue proliferation knuckle, subcutaneous have thrombosis.Mucosa 3,7,11 congested swelling in hemorrhoid district are turned up, and all there is the papillary hyperplasia knuckle at 3,7,11 tooth trace places, 3,7,11 mucocutaneous up and down fusions mutually of tooth trace, and the tooth trace that becomes one partly disappears.There is a wide substrate vegetation at 6 tooth trace places, and the surface is skin, and smooth, its side (nearly 7 directions) has a scarlet radial breach, and edge matter is hard.Anus can hold two and refers to pass through under the narcotism.
Diagnosis: anal papilla shape fibroma
Anal fissure
Mixed hemorrhoid
Dispose: the patient gets lithotomy position, routine disinfection crissum, anus, anorectal region hypomere under narcotism.The Chinese medicine implant that under anoscope, uses the implantation utensil will treat hemorrhoid is implanted under 3,7,11 hemorrhoid district mucosas.Hemostasis is pushed in sterilization, withdraws from anoscope.11 positions of little curved hemostatic forceps clamp external hemorrhoid skin is made wing joint-cutting, and interrupted suture 6 pins are pricked 2 external hemorrhoids of ligation with 11 external hemorrhoid seams.On 3 external hemorrhoid skins, make radial incision, divest 3 loose anal papillas of blood stasis tissue back ligation, stitch pin hemostasis in incision.Postoperative gives conventional antibiotic prophylaxis and infects, and whenever sterilization is changed dressings greatly after an action of the bowels.
Pay a return visit: postoperative check in 21 days, the anus smooth in appearance, the row anoscopy sees that hemorrhoid district mucosa does not have hyperemia, edema, erosion.
Claims (4)
1. the Chinese medicine implant of treatment hemorrhoid, this implant are characterised in that the weight portion of the component that constitutes this implant and each component is following:
Fructus Mume extract 3-10
Radix Et Rhizoma Rhei extract 2-6
Pseudobulbus Bletillae (Rhizoma Bletillae) glue 1-3,
Wherein, Fructus Mume extract is for adopting water or potass extraction, and the dry thing that ethanol precipitate with ethanol or ion-exchange resin purification are processed, Radix Et Rhizoma Rhei extract are to adopt ethanol extraction; The dry thing that the nonpolar macroporous adsorption resin purification is processed, Pseudobulbus Bletillae (Rhizoma Bletillae) glue are the cotton-shaped colloid that the Pseudobulbus Bletillae (Rhizoma Bletillae) makes through aqueous extraction-alcohol precipitation technology.
2. the production method of the Chinese medicine implant of treatment hemorrhoid according to claim 1 is characterized in that the production stage of implant is following:
(1) gets the raw materials ready according to the said components part by weight;
(2) according to the said components part by weight, take by weighing Radix Et Rhizoma Rhei and Fructus Mume extract fine powder and Pseudobulbus Bletillae (Rhizoma Bletillae) glue fine powder and mixing, add 0.5-3 times of water of medicated powder weight, mix well after making the medicated powder swelling, place the drying under reduced pressure case, 60-85 ℃ of dry 0.5-4h;
(3) take out the semi-solid medicine, add in the implant mould compression moulding;
The implant mould that (4) will add medicine takes out medicine in 50-70 ℃ of dry 1-5h, promptly gets.
3. the production method of the Chinese medicine implant of treatment hemorrhoid according to claim 2 is characterized in that the implant mould is the strip mould of length 3-15mm, diameter or diagonal angle, bottom surface line length 0.5-2.0mm.
4. the production method of the Chinese medicine implant of treatment hemorrhoid according to claim 3 is characterized in that the implant mould is the mould of one of bullet shaped, cylindrical, triangular taper, multi-edge column-shaped.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101139704A CN101780217B (en) | 2010-02-25 | 2010-02-25 | TCM implant for treating haemorrhoids and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101139704A CN101780217B (en) | 2010-02-25 | 2010-02-25 | TCM implant for treating haemorrhoids and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN101780217A CN101780217A (en) | 2010-07-21 |
| CN101780217B true CN101780217B (en) | 2012-01-11 |
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| CN2010101139704A Expired - Fee Related CN101780217B (en) | 2010-02-25 | 2010-02-25 | TCM implant for treating haemorrhoids and preparation method thereof |
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