KR102351111B1 - 초속효성 인슐린 제형 및 약제학적 전달 시스템 - Google Patents

초속효성 인슐린 제형 및 약제학적 전달 시스템 Download PDF

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KR102351111B1
KR102351111B1 KR1020167021822A KR20167021822A KR102351111B1 KR 102351111 B1 KR102351111 B1 KR 102351111B1 KR 1020167021822 A KR1020167021822 A KR 1020167021822A KR 20167021822 A KR20167021822 A KR 20167021822A KR 102351111 B1 KR102351111 B1 KR 102351111B1
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insulin
pharmaceutical composition
position corresponding
acid
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KR20160122145A (ko
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제프리 아이. 조셉
리차드 윌리엄 베런슨
브루스 프랭크
마이클 에이. 와이스
토마스 해티어
그레고리 두베
지창 첸
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써멀린 다이어비티즈, 엘엘씨
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration

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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
KR1020167021822A 2014-01-13 2015-01-13 초속효성 인슐린 제형 및 약제학적 전달 시스템 Active KR102351111B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461926946P 2014-01-13 2014-01-13
US201461926944P 2014-01-13 2014-01-13
US61/926,944 2014-01-13
US61/926,946 2014-01-13
PCT/US2015/011202 WO2015106269A2 (en) 2014-01-13 2015-01-13 Rapid action insulin formulations and pharmaceutical delivery systems

Publications (2)

Publication Number Publication Date
KR20160122145A KR20160122145A (ko) 2016-10-21
KR102351111B1 true KR102351111B1 (ko) 2022-01-14

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Country Status (10)

Country Link
US (4) US9901622B2 (https=)
EP (1) EP3094343A4 (https=)
JP (3) JP6944780B2 (https=)
KR (1) KR102351111B1 (https=)
CN (1) CN106102763A (https=)
AU (1) AU2015204491B2 (https=)
BR (1) BR112016016290A2 (https=)
CA (1) CA2936563A1 (https=)
IL (1) IL246706B (https=)
WO (1) WO2015106269A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1762259B2 (en) 2005-09-12 2025-01-01 Unomedical A/S Inserter for an infusion set with a first and second spring units
MX2012011085A (es) 2010-03-30 2012-10-10 Unomedical As Dispositivo medico.
WO2012123274A1 (en) 2011-03-14 2012-09-20 Unomedical A/S Inserter system with transport protection
WO2013050277A1 (en) 2011-10-05 2013-04-11 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
EP2919804B1 (fr) 2012-11-13 2018-01-31 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
WO2016105545A2 (en) * 2014-12-24 2016-06-30 Case Western Reserve University Insulin analogues with enhanced stabilized and reduced mitogenicity
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
WO2017125817A1 (en) 2016-01-19 2017-07-27 Unomedical A/S Cannula and infusion devices
MY200047A (en) 2016-11-21 2023-12-06 Univ Case Western Reserve Rapid-acting insulin analogues of enhanced stability
US10709834B2 (en) * 2016-12-21 2020-07-14 Medtronic Minimed, Inc. Medication fluid infusion set component with integrated physiological analyte sensor, and corresponding fluid infusion device
TW201835099A (zh) * 2017-03-07 2018-10-01 美國凱斯西方瑞瑟夫大學 藉由第四雙硫鍵穩定之單鏈胰島素類似物
GB201707187D0 (en) * 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707189D0 (en) * 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
KR20190140048A (ko) 2017-06-01 2019-12-18 일라이 릴리 앤드 캄파니 신속-작용 인슐린 조성물
US11510967B2 (en) 2017-09-08 2022-11-29 Eli Lilly And Company Pharmaceutical combinations comprising insulin and at least an agent selected from meloxicam, bromfenac sodium, acetylsalicylic acid, salicyclic acid and paracetamol
CN108489941B (zh) * 2018-01-31 2021-07-27 吉林大学 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用
IL277721B2 (en) * 2018-04-04 2024-03-01 Arecor Ltd Medical infusion pump system for the delivery of an insulin compound
WO2020061554A1 (en) * 2018-09-21 2020-03-26 Case Western Reserve University Site 2 single-chain insulin analogues
US20220235111A1 (en) * 2019-05-17 2022-07-28 Case Western Reserve University Variant Single-Chain Insulin Analogues
US11458292B2 (en) 2019-05-20 2022-10-04 Unomedical A/S Rotatable infusion device and methods thereof
EP4051337A4 (en) * 2019-10-30 2023-11-01 Thermalin Inc. DRUG RELEASE SYSTEMS, DEVICES AND METHODS
US12610742B2 (en) 2019-11-25 2026-04-21 Aita Bio Inc. Micropump and method of fabricating the same
NL2025679B1 (en) * 2020-05-26 2021-12-13 Johanna Daams Brechtje Electrical stimulation for preventing or treating nitric oxide deficiency related conditions
AU2021335128A1 (en) 2020-08-23 2023-04-27 Pacific Diabetes Technologies Inc Measurement of glucose near an insulin delivery catheter by minimizing the adverse effects of insulin preservatives: alternative ligands and redox mediator metals
US20220386905A1 (en) * 2021-03-02 2022-12-08 Pacific Diabetes Technologies Inc Signal processing algorithm for improving accuracy of a continuous glucose sensor and a combined continuous glucose sensor and insulin delivery cannula
KR102678960B1 (ko) * 2021-08-26 2024-06-27 주식회사 에이피알 바디 관리기
US20240149021A1 (en) * 2022-11-04 2024-05-09 Becton, Dickinson And Company Intravenous Catheter Securement Sleeve
US20240216649A1 (en) * 2023-01-03 2024-07-04 Becton, Dickinson And Company Management of Catheters and Accessories During Intravascular Catheter Maintenance
US20250242110A1 (en) * 2024-01-26 2025-07-31 Medtronic Minimed, Inc. Fluid delivery filters
WO2025245624A1 (en) * 2024-05-28 2025-12-04 Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines S.E.C. New insulin formulations for use in insulin pumps

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009533471A (ja) * 2006-04-12 2009-09-17 バイオデル， インコーポレイテッド 即効型および長時間作用型組合せインスリン製剤

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK134691D0 (da) * 1991-07-12 1991-07-12 Novo Nordisk As Apparat
US5461031A (en) 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
ZA984697B (en) * 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
WO2001000674A1 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Insulin crystals for pulmonary administration
AU2002346491A1 (en) * 2001-12-19 2003-07-09 Eli Lilly And Company Crystalline compositions for controlling blood glucose
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
WO2007081824A2 (en) 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US9220837B2 (en) * 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US7858037B2 (en) * 2007-03-30 2010-12-28 Instrumentation Laboratory Company Adaptor for sample vial
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
RU2010147076A (ru) 2008-04-22 2012-05-27 Кейз Вестерн Ризев Юнивесити (Us) Аналоги инсулина специфичные к изоформам
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
CA2732439A1 (en) * 2008-07-31 2010-02-04 Case Western Reserve University Halogen-stabilized insulin
WO2010080606A1 (en) * 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Insulin analogs
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
EA201200717A1 (ru) * 2009-12-11 2013-03-29 Кейз Вестерн Ризев Юнивесити Аналоги инсулина, содержащие хлорированные аминокислоты
CN102770153B (zh) 2010-02-22 2014-05-07 卡斯西部储备大学 呈可溶和结晶形式的长效胰岛素类似物制剂
US9487572B2 (en) 2011-07-13 2016-11-08 Case Western Reserve University Non-standard insulin analogues
JP2014533241A (ja) * 2011-10-27 2014-12-11 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 超濃縮速効型インスリン類似体製剤
WO2013067022A1 (en) * 2011-10-31 2013-05-10 Xeris Pharmaceuticals, Inc. Formulations for the treatment of diabetes
CA2898730A1 (en) 2012-01-20 2013-07-25 Case Western Reserve University Glutamic acid-stabilized insulin analogues
US9381247B2 (en) * 2012-04-16 2016-07-05 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
MX2015005662A (es) 2012-11-05 2015-08-20 Univ Case Western Reserve Analogos de insulina de una sola cadena de larga accion.
MX2015009399A (es) * 2013-01-22 2016-04-13 Univ Case Western Reserve Analogos de insulina truncados en n-terminal.
BR112015023672A2 (pt) 2013-03-15 2017-07-18 Univ Case Western Reserve análogo de insulina, orto-fluoro, sequência de dna codificando a cadeia a de análogo de insulina, sequência de dna codificando a cadeia b de análogo de insulina e uso de um análogo de insulina.
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
AU2015328222B9 (en) 2014-10-06 2020-12-24 Case Western Reserve University Biphasic single-chain insulin analogues
US20170304361A1 (en) 2014-10-20 2017-10-26 Case Western Reserve University Halogenated insulin analogues of enhanced biological potency
WO2016105545A2 (en) 2014-12-24 2016-06-30 Case Western Reserve University Insulin analogues with enhanced stabilized and reduced mitogenicity
CN107428814A (zh) 2015-01-20 2017-12-01 卡斯西部储备大学 具有选择性信号传导特性和降低的促有丝分裂性的胰岛素类似物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009533471A (ja) * 2006-04-12 2009-09-17 バイオデル， インコーポレイテッド 即効型および長時間作用型組合せインスリン製剤

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