KR102349786B1 - Cosmetic composition for anti-wrinkle and skin whitening - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a Houttuynia cordata extract, a Senna alata extract, and a Hamamelis Virginianaract as active components. The cosmetic composition of the present invention contains various natural ingredients and natural extracts in addition to the Houttuynia cordata extract, the Senna alata extract, and the Hamamelis Virginianaract, so that there are excellent antibacterial activity on acne bacteria, wrinkle alleviation activity, and skin whitening activity. Therefore, the cosmetic composition can be used in various ways in the cosmetic field.

Description

Cosmetic composition for wrinkle improvement and whitening {Cosmetic composition for anti-wrinkle and skin whitening}

The present invention is a cosmetic composition comprising an eosinth plant extract, a candle bush extract, and a witch hazel extract as active ingredients, and is characterized in that it exhibits wrinkle improvement, trouble improvement, and whitening effects.

The skin is divided into endogenous aging, which occurs when the secretion of hormones decreases over time and the functional activity of immune cells decreases and the biosynthesis of biological constituent proteins decreases, and photoaging caused by externally polluted air, drugs, and ultraviolet rays.

As aging progresses, the ability to produce structural proteins such as collagen, elastin, and hyaluronic acid, which are substances constituting the skin, decreases, and the biosynthesis of type-1 collagen increases and the expression of matrix metalloproteinases (MMPs) increases. It induces the breakdown of matrix proteins such as elastic fibers, fibronectin and laminin, which reduces skin elasticity and causes skin wrinkles. Recent studies have reported that elastase plays an important role in the three-dimensional distortion of skin elastic fibers. Increased activity of elastase contributes to skin wrinkle formation by reducing skin elastic fibers, and oxidative stress further accelerates skin aging.

In addition, when exposed to ultraviolet light, signal transduction substances such as α-melanocyte stimulating hormone (α-MSH) and adrenocorticotropichormone are secreted into melanocytes. Melanin is produced inside the melanosome and the amino acid L-tyrosine is converted to dopaquinone by the enzyme tyrosinase. However, excessive melanin production can cause various problems such as melanoma, post-inflammatory pigmentation, and freckles.

Eoseongcho ( Houttuynia cordata Thunb) is a perennial herb belonging to the family Trifoliumaceae, and it grows well in shady and wet places. Eoseongcho contains various physiologically active substances and has been used for a long time as a herbal medicine with diuretic, analgesic, and hemostasis pharmacological effects (Korean J. Food Preserv., 16(1): 122-127). In relation to the activity of eoseongcho, it has been reported on the cancer cell suppression effect of eoseongcho hexane extract, antimutagenic effect, effect on serum lipids and lipid components of high fat and hypercholesterolemic mice (J. Korean Soc. Food Sci. Nutr 27, 1230-1235, 1998) have been studied.

Under this background, the present inventors confirmed that the composition comprising eosinthia extract, candle bush extract, witch hazel extract, and various natural extracts in a specific weight ratio has excellent antibacterial activity and anti-wrinkle activity against acne bacteria, and high whitening activity Thus, the present invention was completed.

One object of the present invention is to provide a cosmetic composition comprising an extract of eosinthia, a candle bush extract, and a witch hazel extract.

This will be described in detail as follows. Meanwhile, each description and embodiment disclosed in the present invention may be applied to each other description and embodiment. That is, all combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be considered that the scope of the present invention is limited by the specific descriptions described below.

One aspect of the present invention for achieving the above object provides a cosmetic composition comprising an eoseongcho extract, a candle bush extract, and a witch hazel extract.

Eoseongcho (Houttuynia cordata ) of the present invention is a wild herb of the perennial herb belonging to the family Trifoliumea. Eoseongcho was given the name because the leaves emit a unique fishy smell, and contains various physiologically active substances, and has been used as a herbal medicine with pharmacological effects such as diuresis, analgesia, and hemostasis from a long time ago. According to previous studies, Eoseongcho has been reported to have various effects such as antioxidant, detoxifying, and anti-inflammatory activities, and is actually being actively used as a raw material in industries such as cosmetics manufacturing. However, there have been no reports of skin-related synergistic effects according to the mixing conditions with other natural products such as candle bush or witch hazel. The source of the eoseongcho is not limited, but may be collected in Ulleungdo.

Candlebush (Cassia alata, Senna alata, Candlebush) of the present invention is a shrub belonging to the family Fabaceae found in a subtropical region, and mainly inhabits sunny and humid places. Candlebush has been used as a folk remedy for skin diseases such as digestive system and athlete's foot, and it has been reported that the extract is effective for liver disease, skin rash, antidiabetes, antimalarial, etc. (Fitoterapia 80, 385-393, 2009) . However, the activity of Candlebush extract such as skin whitening or wrinkle improvement has not yet been specifically studied.

Witch hazel ( Hamamelis virginiana , Witch-hazel ) of the present invention is a plant of the genus of perennials, and is distributed in Japan, China and North America. Witch hazel mainly contains tannins, catechins, and flavonoids, and according to folk remedies, the leaves and peel of witch hazel have astringent, anti-inflammatory and hemostatic properties. In addition, although antioxidant, anti-inflammatory and antiviral activity of witch hazel has been reported, the activity of witch hazel extract, such as skin whitening or wrinkle improvement, has not been specifically studied.

The term "extract" of the present invention means that if the active ingredient contained in the extraction raw material can be separated from the active ingredient contained in the extraction raw material by contacting the solvent and the extraction raw material under specific conditions, all of them will be included regardless of the extraction method or the type of active ingredient can For example, extracts of components soluble in solvents from raw materials using water or an organic solvent, and extracts obtained by extracting only specific components such as specific components of raw materials, such as oil, may be included. The extract may be powdered after drying, or may be obtained by various conventionally known extraction methods such as hot water extraction and ethanol extraction. The extract is selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, petroleum ether, ethyl acetate, butyl acetate, trichloromethane, dichloromethane, chloroform, hexane and 1,3-butylene glycol It can be extracted with one or more solvents. Specifically, it may be extracted with 50% (v/v) ethanol. In a specific embodiment of the present invention, elastase of the extract extracted using hot water, 50% (v/v) ethanol, and 100% ethanol as a solvent by mixing eoseongcho, candle bush, and witch hazel powder in the same weight ratio ) As a result of evaluating the inhibitory activity, it was confirmed that the 50% (v/v) ethanol extract showed the highest inhibitory effect (Experimental Example 1).

The extract may also include an extract that has undergone a conventional purification process. For example, the extract is separated using an ultrafiltration membrane having a constant molecular weight cut-off value, and various purification methods are additionally performed, such as separation by various chromatography (prepared for separation according to size, charge, hydrophobicity or affinity). It may include a fraction obtained through

The Eoseongcho extract, Candlebush extract, and witch hazel extract included in the cosmetic composition of the present invention may be mixed in a weight ratio of 5:2:1. In a specific embodiment of the present invention, in order to identify a mixing ratio that can exhibit an optimal synergistic effect when each of the extracts is mixed, the weight ratio of each extract is varied and mixed with the composition of Examples and Comparative Examples for acne bacteria. Antibacterial activity was compared. As a result, it was confirmed that the composition of Example 1 containing the eosinus extract, the Candlebush extract, and the witch hazel extract in a weight ratio of 5:2:1 had the best antibacterial activity against the dermatitis-inducing strain (Experimental Example 2). The mixing method is not limited, such as extracting by mixing eoseongcho, candle bush and witch hazel raw material in the above weight ratio, or mixing each extract in the above weight ratio.

The cosmetic composition of the present invention may further include squalane, magnolia bark extract, white willow bark extract, white willow bark extract, macadamia seed oil, and jojoba seed oil.

Squalane of the present invention is a chemical _{compound of C 30} H ₆₂ , and is a hydrocarbon derived by hydrogenation of squalene. It is found in large quantities in shark liver oil, and is also found in olive oil, wheat germ oil, rice bran oil, and yeast. The method of obtaining the squalane of the present invention is not limited, such as purchasing commercially available ingredients or directly synthesizing and using the squalane.

Eoseongcho, candle bush, witch hazel, magnolia bark, white willow bark, rhododendron bark, macadamia seeds, and jojoba seeds of the present invention can be directly collected or purchased commercially available products, but are not limited thereto. does not

The cosmetic composition of the present invention is specifically formulated with 50 parts by weight of Eosongcho extract, 20 parts by weight of Candlebush extract, 10 parts by weight of witch hazel extract, 60 parts by weight of squalane, 20 parts by weight of magnolia bark extract, 15 parts by weight of white willow bark extract, It may contain 5 parts by weight of Nahanifolia extract, 15 parts by weight of macadamia seed oil, and 10 parts by weight of jojoba seed oil. In a specific embodiment of the present invention, the tyrosinase inhibitory activity of the compositions of Examples and Comparative Examples containing squalane, magnolia bark extract, white willow bark extract, and rhododendron bark extract in different weight ratios compared. As a result, 50 parts by weight of Eoseongcho extract, 20 parts by weight of Candlebush extract, 10 parts by weight of witch hazel extract, 60 parts by weight of squalane, 20 parts by weight of magnolia bark extract, 15 parts by weight of white willow bark extract, 5 parts by weight of Nahana birch extract It was confirmed that the composition of Example 2 including parts by weight, 15 parts by weight of macadamia seed oil, and 10 parts by weight of jojoba seed oil had the highest tyrosinase inhibitory activity (Experimental Example 3).

The cosmetic composition of the present invention has an effective activity of the present invention in addition to the eosinth plant extract, candlebush extract, and witch hazel extract, squalane, magnolia bark extract, white willow bark extract, white willow bark extract, macadamia seed oil, and jojoba seed oil. It can be used by additionally including a known natural extract or other ingredients for skin improvement in a range that does not inhibit the skin. Specifically, the cosmetic composition of the present invention is butylene glycol, glycerin, panthenol, caprylic/capric triglyceride, beeswax, arbutin, cetearyl alcohol, sorbitan stearate, 1,2-hexanediol , Dimethicone, Lactobacillus / Centella asiatica extract fermentation filtrate, hydroxyacetophenone, polysorbate 60, polyacrylate-13, arginine, acrylate/C10-30 alkyl acrylate crosspolymer, cetearylglucoside, Tocopheryl acetate, glyceryl stearate, polyisobutene, allantoin, ceramide NP, polysorbate 20, asiaticoside, adenosine, sorbitan isostearate, asiatic acid, sodium hyaluronate, madecasic acid, lavender Oil, golden extract, beta-glucan, green tea extract, king tangerine extract, propolis extract, matricaria flower/leaf extract, palmitoyl tripeptide-1, and linalool may be additionally included, but are not limited thereto.

In addition, in the cosmetic composition of the present invention, in addition to the above essential ingredients, other ingredients may be appropriately blended within the range that does not impair the purpose according to the present invention, depending on the type of formulation or purpose of use. The cosmetic composition of the present invention may include a conventionally acceptable carrier, for example, oil, water, surfactant, humectant, lower alcohol, thickener, chelating agent, colorant, preservative, fragrance, etc. may be appropriately blended, but limited thereto it is not going to be The acceptable carrier may vary depending on the formulation.

The cosmetic composition of the present invention may be prepared in any conventionally prepared formulation, for example, a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing agent, oil, It may be formulated as powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, flexible lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray, powder, pact, lip gloss, lipstick, shadow, shampoo and conditioner, etc. It may be prepared in a formulation of, preferably a cream formulation.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol, or fatty acid ester of sorbitan is used.

The cosmetic composition of the present invention may be characterized in that it exhibits wrinkle improvement, trouble improvement, and whitening effect.

The term “wrinkle” refers to fine lines caused by skin aging, and may be caused by a genetic cause, a decrease in collagen present in the dermis of the skin, an external environment, and the like. As used herein, the term "wrinkle improvement" refers to preventing, suppressing or inhibiting the symptoms of wrinkles.

The cosmetic composition of the present invention may exhibit wrinkle improvement activity by inhibiting the activity of elastase. The elastase refers to an enzyme that catalyzes the hydrolysis reaction of elastin involved in skin elasticity.

The term "trouble improvement" of the present invention may be achieved through antibacterial activity against Propionibacterium acnes strains and Staphylococcus epidermidis strains.

Propionibacterium acnes ( Propionibacterium acnes ) is an anaerobic bacterium, which grows inside the hair follicles, and is known as the causative agent of acne. Specifically, when the sebum on the skin becomes excessive due to the action of hormones, and accordingly, the keratinization of the pores is caused and the sebum cannot be discharged out of the pores, the Propionibacterium acnes strain present in the sebum proliferates and causes acne-like symptoms such as acne. skin disease is exacerbated.

Staphylococcus epidermidis ( Staphylococcus epidermidis ) is an aerobic bacterium, grows in the middle of the outer follicle or hair follicle, and is non-pathogenically isolated from animal skin, milk, cheese, and other brews. It is the causative agent of secondary exacerbation of primary skin diseases and acne. Due to its slime-producing ability, it protects cells from antibiotics and prevents phagocytosis, an immune response of the host. It is known to inhibit hemagglutination and damage the immune system of the host.

The cosmetic composition of the present invention can help relieve troubled skin by inhibiting harmful skin bacteria such as Propionibacterium acnes strain and Staphylococcus epidermis strain without the use of chemical antibiotics.

As used herein, the term "whitening" refers to suppressing the production of various biomolecules such as melanin, oxidation-reduction hemoglobin, carotene, and melanoids that affect skin color, thereby alleviating skin pigmentation phenomena such as blemishes, freckles, and freckles, and making the skin yellowish It refers to the effect of improving skin brightness and uniformity by alleviating redness and redness. Specifically, in the present invention, skin whitening was used to mean the effect of brightening the skin tone and increasing the brightness, but is not limited thereto.

One aspect of the present invention for achieving the above object, provides a quasi-drug composition for antibacterial, whitening, and wrinkle improvement comprising an eoseongcho extract, a candle bush extract and a witch hazel extract.

The term "quasi-drug" as used in the present invention refers to articles with a milder action than pharmaceuticals among articles used for the purpose of diagnosing, treating, improving, alleviating, treating or preventing diseases of humans or animals, for example, in the Pharmaceutical Affairs Act. According to the report, quasi-drugs exclude products used for medicinal purposes, and include products used for the treatment or prevention of diseases in humans and animals, and products with minor or no direct action on the human body. The quasi-drug composition of the present invention may be prepared selected from the group consisting of body cleanser, foam, soap, mask, ointment, cream, lotion, essence and spray, but is not limited thereto. When the composition according to the present invention is used as a quasi-drug additive, the composition may be added as it is or used together with other quasi-drugs or quasi-drug ingredients, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient may be suitably determined according to the purpose of use.

The cosmetic composition of the present invention has excellent antibacterial activity, anti-wrinkle activity, and skin whitening activity against acne bacteria by including various natural ingredients and natural extracts in addition to eoseongcho extract, candle bush extract, and witch hazel extract, and is widely used in the cosmetic field. can be

Hereinafter, the present invention will be described in more detail through examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.

Experimental Example 1. Evaluation of wrinkle improvement activity according to the extraction solvent

Houttuynia cordata leaves, Candlebush ( Cassia alata ) leaves, and witch hazel ( Hamamelis virginiana ) leaves included in the cosmetic composition of the present invention are dried and pulverized to obtain each powder, and then mixed in the same weight ratio with distilled water; 50% (v/v) ethanol and 100% (v/v) ethanol were used as solvents, and extraction was performed at 90 to 100° C. for 4 hours. Thereafter, each sample was prepared by filtration.

Then, in order to evaluate the wrinkle improvement activity according to the extraction solvent, the inhibitory activity on elastase, an elastin degrading enzyme, was measured. Specifically, the amount of p-nitroanilide produced from the substrate was measured at 445 nm using n-succinyl-(L-Ala) _{3 -p-nitroanilide as a substrate at 37° C. for 30 minutes.} Take 40 μL of each sample in a 96-well plate, add 40 μL of 2.5 U/mL porcine pancreas elastase solution in 50 mM tris-HCl buffer (pH 8.6), and then add n- dissolved in 50 mM tris-HCl buffer as a substrate. It was measured by adding succinyl-(L-Ala) ₃ -p-nitroanilide (0.5 mg/mL) and reacting for 30 minutes. Elastase inhibitory activity was expressed as the absorbance reduction rate of the group with and without the sample solution, and the specific calculation formula is as follows.

Enzyme activity inhibition (%) = (1-Absorbance with sample addition/absorbance without addition) Х100

extraction solvent Inhibition rate (%) hot water 25.6 50% (v/v) EtOH 48.8 100% (v/v) EtOH 34.5

Elastase is an enzyme that degrades elastin, a protein, and is a non-specific hydrolase that can degrade collagen, another important matrix protein. In the dermal tissue of the skin, collagen and elastin related to the elasticity of the skin are formed in a network structure. Since elastin is decomposed by elastase and the bond to the network structure of the skin is broken, elastase is known as an enzyme that is the main cause of wrinkles have.

As a result of measuring the elastase inhibitory activity related to the wrinkle formation, as shown in Table 1 above, the hot water extraction showed a low inhibitory activity of about 25.6%, whereas the 50% (v/v) ethanol extract had the highest 48.8% showed inhibitory activity, and it was confirmed that the inhibitory activity was rather reduced in the 100% ethanol extract. That is, it can be inferred that the most active ingredients exhibiting wrinkle-improving activity through elastase inhibition are extracted when eoseongcho, candle bush, and witch hazel are extracted with 50% (v/v) ethanol.

Therefore, in the following, the activity was evaluated using a 50% (v/v) ethanol extract of Eoseongcho, Candlebush, and witch hazel.

Experimental Example 2. Evaluation of antibacterial activity

According to the results of Experimental Example 1, prepare a 50% (v / v) ethanol extract of Eosangcho, candle bush, and witch hazel, and when mixing each extract, in order to identify a mixing ratio that can exhibit an optimal synergistic effect The compositions of Examples and Comparative Examples were prepared by mixing each extract as shown in the weight ratio in Table 2 below.

weight ratio Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Eoseongcho Extract 5 2 One One Candlebush Extract 2 5 2 One witch hazel extract One One 5 One

The antibacterial activity of the compositions of Examples and Comparative Examples was measured using disc diffusion assay, and Propionibacterium acnes strain and Staphylococcus epidermidis were used as strains. Specifically, the compositions of Examples and Comparative Examples were used after being diluted in DMSO at a concentration of 300 mg/L, and the two liquid-cultured strains were uniformly spread on an agar plate by 100 μL and sterilized on a paper disk (diameter of 8 mm). ) is placed on the agar plate. Each composition was injected and diffused into the paper disk, and then incubated at 37°C for 24 hours to measure the size (mm) of the clear zone around the paper disk to measure the degree of activity.

Clear zone (mm) Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 P. acnes 17.1 13.5 10.9 15.0 S. epidermis 15.9 14.1 8.2 14.3

As shown in Table 3, the antibacterial activity of the composition of Example 1 was the best, followed by Comparative Example 3, Comparative Example 1, and Comparative Example 2 in that order. In other words, it was confirmed that the composition containing the extract of eosinthiasis in a high weight ratio had high antibacterial activity against skin acne or dermatitis-inducing strains. Accordingly, the cosmetic composition of the present invention can help relieve acne-prone skin.

Experimental Example 3. Evaluation of whitening activity

According to the results of Experimental Example 2, the extracts of Eosinaceae extract, Candlebush extract, and witch hazel were included in a weight ratio of 5:2:1, and squalane, magnolia bark extract, white willow bark extract, rhododendron extract, macadamia Example 2 and Comparative Examples 4-7 cosmetic compositions comprising seed oil and jojoba seed oil in different weight ratios, including squalane, magnolia bark extract, white willow bark extract, and rhododendron extract did

parts by weight Example 2 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Eoseongcho Extract 50 50 50 50 50 Candlebush Extract 20 20 20 20 20 witch hazel extract 10 10 10 10 10 squalane 60 50 50 70 60 Magnolia Bark Extract 20 30 20 10 10 White Willow Bark Extract 15 10 20 5 20 One hundred branches of Nahana tree extract 5 10 10 15 10 Macadamia Seed Oil 15 15 15 15 15 Jojoba Seed Oil 10 10 10 10 10

In order to analyze the whitening activity of the compositions of Examples and Comparative Examples, inhibitory activity against tyrosinase was measured. Specifically, B16F10 melanoma cells were inoculated into 6-wells to become 5x10 ⁴ cells and cultured, and 24 hours later, samples were treated in each well for 48 hours. After treatment, the cells were washed twice with PBS, and then a lysis buffer was added to the cells in each well. Cells were disrupted on ice and centrifuged, and only the supernatant was collected separately and used as an enzyme solution. Prepare a substrate by dissolving L-DOPA in 0.1 M sodium phosphate buffer (pH 6.8) at a concentration of 2 mg/mL, add 40 μL of enzyme solution to 160 μL of substrate, heat at 37° C. for 1 hour, and measure the amount of DOPA chrome produced at 490 nm. measured. Cellular tyrosinase activity was calculated from the absorbance ratio of the addition group and the non-addition group of each sample.

division Inhibition rate (%) Example 2 39.4 Comparative Example 4 30.8 Comparative Example 5 26.6 Comparative Example 6 21.7 Comparative Example 7 32.5

Tyrosinase (tyrosinase) is the most important enzyme in the production of melanin from tyrosine when the skin is exposed to ultraviolet light. It is known that by inhibiting tyrosinase activity, melanin production can be inhibited, thereby preventing the induction of spots, freckles, senile erythema, and the like.

As a result of measuring the intracellular tyrosinase inhibitory activity, as shown in Table 5 above, the tyrosinase inhibitory activity of the composition of Example 2 was the highest, and squalane, magnolia bark extract, white willow bark extract, and It was confirmed that the composition of Comparative Example containing the Nahanbaekji tree extract in different weight ratios exhibited lower activity than the composition of Example 2. Therefore, there is a difference in whitening activity according to the inhibition of tyrosinase enzyme according to the content of each natural extract and component included in the cosmetic composition, and 50 parts by weight of eosinthia extract, 20 parts by weight of Candlebush extract, 10 parts by weight of witch hazel extract Part, 60 parts by weight of squalane, 20 parts by weight of magnolia bark extract, 15 parts by weight of white willow bark extract, 5 parts by weight of oleander extract, 15 parts by weight of macadamia seed oil, and 10 parts by weight of jojoba seed oil It was confirmed through a specific experiment that it has the best whitening activity. Accordingly, the cosmetic composition of the present invention can help skin whitening.

From the above description, those skilled in the art to which the present invention pertains will understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential characteristics thereof. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention, rather than the above detailed description, all changes or modifications derived from the meaning and scope of the claims to be described later and their equivalents.

Claims (5)

As a cosmetic composition comprising Eoseongcho extract, Candlebush extract, witch hazel extract, squalane, magnolia bark extract, white willow bark extract, rhododendron extract, macadamia seed oil, and jojoba seed oil,
The Eoseongcho extract, Candlebush extract, and witch hazel extract are extracted with 50% (v/v) ethanol, and the Eoseongcho extract, Candlebush extract, and witch hazel extract are mixed in a weight ratio of 5:2:1. ,
The cosmetic composition is characterized in that it exhibits wrinkle improvement, trouble improvement, and whitening effect.
delete delete According to claim 1,
The composition comprises: 50 parts by weight of eoseongcho extract, 20 parts by weight of Candlebush extract, 10 parts by weight of witch hazel extract, 60 parts by weight of squalane, 20 parts by weight of magnolia bark extract, 15 parts by weight of white willow bark extract, 5 parts by weight of Nahanbaekji tree extract A cosmetic composition comprising 1 part by weight, 15 parts by weight of macadamia seed oil, and 10 parts by weight of jojoba seed oil.
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