KR102330185B1 - 회전 박막 여과를 사용한 크기 기반 세포 분리를 위한 방법 - Google Patents

회전 박막 여과를 사용한 크기 기반 세포 분리를 위한 방법 Download PDF

Info

Publication number
KR102330185B1
KR102330185B1 KR1020140168193A KR20140168193A KR102330185B1 KR 102330185 B1 KR102330185 B1 KR 102330185B1 KR 1020140168193 A KR1020140168193 A KR 1020140168193A KR 20140168193 A KR20140168193 A KR 20140168193A KR 102330185 B1 KR102330185 B1 KR 102330185B1
Authority
KR
South Korea
Prior art keywords
suspension
rotational speed
cell type
membrane separator
rotating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020140168193A
Other languages
English (en)
Korean (ko)
Other versions
KR20150076076A (ko
Inventor
크리스토퍼 웨게너
브렛 올슨
민경윤
Original Assignee
펜월, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 펜월, 인크. filed Critical 펜월, 인크.
Publication of KR20150076076A publication Critical patent/KR20150076076A/ko
Application granted granted Critical
Publication of KR102330185B1 publication Critical patent/KR102330185B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496Plasmapheresis; Leucopheresis; Lymphopheresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/262Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/262Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
    • A61M1/265Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating inducing Taylor vortices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3627Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633Blood component filters, e.g. leukocyte filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16Rotary, reciprocated or vibrated modules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3365Rotational speed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2315/00Details relating to the membrane module operation
    • B01D2315/02Rotation or turning

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)
  • Combined Means For Separation Of Solids (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Filtration Of Liquid (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020140168193A 2013-12-26 2014-11-28 회전 박막 여과를 사용한 크기 기반 세포 분리를 위한 방법 Active KR102330185B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/140,978 2013-12-26
US14/140,978 US9713669B2 (en) 2013-12-26 2013-12-26 Method for sized-based cell separation using spinning membrane filtration

Publications (2)

Publication Number Publication Date
KR20150076076A KR20150076076A (ko) 2015-07-06
KR102330185B1 true KR102330185B1 (ko) 2021-11-24

Family

ID=51790616

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020140168193A Active KR102330185B1 (ko) 2013-12-26 2014-11-28 회전 박막 여과를 사용한 크기 기반 세포 분리를 위한 방법

Country Status (6)

Country Link
US (1) US9713669B2 (enExample)
EP (1) EP2889050B1 (enExample)
JP (1) JP6453646B2 (enExample)
KR (1) KR102330185B1 (enExample)
AU (1) AU2014277687B2 (enExample)
NZ (1) NZ700425A (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10688233B2 (en) * 2014-12-19 2020-06-23 Fenwal, Inc. Method and system for the automated processing of biological fluid during low level alert condition
EP3907276A4 (en) 2020-03-11 2022-03-30 Showa Denko Materials Co., Ltd. DEVICE AND METHOD FOR CELL RECOVERY, CELL SEPARATION SYSTEM AND CELL SEPARATION METHOD
JP2022037418A (ja) * 2020-08-25 2022-03-09 ソニーグループ株式会社 試料調製装置及び試料調製システム

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000501338A (ja) 1996-09-25 2000-02-08 バクスター・インターナショナル・インコーポレイテッド 医用液および生体液を濾過するシステム

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3279765D1 (en) 1981-07-22 1989-07-20 Du Pont Plasmapheresis by reciprocatory pulsatile filtration
US5034135A (en) 1982-12-13 1991-07-23 William F. McLaughlin Blood fractionation system and method
US4911847A (en) 1983-12-20 1990-03-27 Membrex, Inc. Process for controlling the permeate composition in a rotary filtration device
ATE108693T1 (de) 1984-03-21 1994-08-15 Mclaughlin William F Filtration einer flüssigen suspension.
DE3631804A1 (de) 1986-09-18 1988-03-24 Altenburger Electronic Gmbh Verfahren und vorrichtung zur herstellung von mikrofiltern, sowie hiernach hergestelltes mikrofilter
GB8628723D0 (en) 1986-12-02 1987-01-07 Bellhouse Brian John Particle separation
JPS6475015A (en) 1987-09-18 1989-03-20 Terumo Corp Filter for separating leukocytes
DE3742770A1 (de) 1987-12-17 1989-06-29 Akzo Gmbh Mikro-/ultrafiltrationsmembranen mit definierter porengroesse durch bestrahlung mit gepulsten lasern und verfahren zur herstellung
US4994188A (en) * 1988-02-05 1991-02-19 Baxter International Inc. Adaptive filtrate flow control system using controlled reduction in filter efficiency
FR2668076B1 (fr) * 1990-10-18 1993-04-30 Kodak Pathe Procede de separation de constituants solides d'une suspension et dispositif de mise en óoeuvre du procede.
NL9200902A (nl) 1992-05-21 1993-12-16 Cornelis Johannes Maria Van Ri Keramisch membraan voor microfiltratie, alsmede werkwijze ter vervaardiging van een dergelijk membraan.
JP3311091B2 (ja) 1993-06-27 2002-08-05 テルモ株式会社 白血球分離用フィルター並びに白血球および血小板分離用フィルター
NL9401260A (nl) 1993-11-12 1995-06-01 Cornelis Johannes Maria Van Ri Membraan voor microfiltratie, ultrafiltratie, gasscheiding en katalyse, werkwijze ter vervaardiging van een dergelijk membraan, mal ter vervaardiging van een dergelijk membraan, alsmede diverse scheidingssystemen omvattende een dergelijk membraan.
US5807406A (en) 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
JP2000237633A (ja) * 1999-02-19 2000-09-05 Matsushita Electric Ind Co Ltd 遠心濾過器を用いた浄化装置及びこれに用いる汚れ検知センサ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000501338A (ja) 1996-09-25 2000-02-08 バクスター・インターナショナル・インコーポレイテッド 医用液および生体液を濾過するシステム

Also Published As

Publication number Publication date
JP6453646B2 (ja) 2019-01-16
EP2889050A1 (en) 2015-07-01
AU2014277687B2 (en) 2018-10-04
US9713669B2 (en) 2017-07-25
KR20150076076A (ko) 2015-07-06
NZ700425A (en) 2016-07-29
US20150182682A1 (en) 2015-07-02
AU2014277687A1 (en) 2015-07-16
JP2015164414A (ja) 2015-09-17
EP2889050B1 (en) 2019-08-21

Similar Documents

Publication Publication Date Title
EP0877648B1 (en) System for filtering medical and biological fluids
US4808307A (en) Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
EP0231623A2 (en) Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
AU616463B2 (en) Method and apparatus for filtration
EP0112152B1 (en) Blood fractionation system and method
Beaudoin et al. Plasma filtration in Couette flow membrane devices
KR102330185B1 (ko) 회전 박막 여과를 사용한 크기 기반 세포 분리를 위한 방법
KR20180081354A (ko) 엑소좀을 포함하는 생체분자 연속 분리용 장치 및 이를 이용한 분리방법
WO2014144782A2 (en) Systems and methods for active particle separation
US9033858B2 (en) Method and apparatus for concentrating platelets from platelet-rich plasma
EP0310205B1 (en) Filtering a liquid suspension
US20170182464A1 (en) Membrane separation device having improved filtration velocity
JP2017516529A (ja) 全血からの血漿の回転膜ろ過の間のファウリングと補体蛋白質の活性化を制御する方法
JP6621482B2 (ja) 赤血球を含有する流体と濃縮赤血球の白血球低減のためのシステムと方法
JPH0669491B2 (ja) 中間密度物質を懸濁液から直接得るための連続遠心装置
WO2022044600A1 (ja) 試料調製装置及び試料調製システム
Mane et al. Isolation of white blood cells from human blood in a microfluidic device
US20250281930A1 (en) Inertial microfluidic separation system
US20250276291A1 (en) Fluid filtration apparatus and related methods
Chen et al. Platelet concentrates preparation using a rotating membrane with Taylor vortices and axial flow
Bhal Designing a continuous, high throughput flow-filter for whole blood fractionation and enrichment

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5