KR102277184B1 - Cosmetic composition - Google Patents

Abstract

As a cosmetic composition with significantly improved whitening performance while minimizing skin irritation, 100 parts by weight of Niacinamide, 0.001 parts by weight to 0.03 parts by weight of Resveratrol, 0.1 to 1.5 parts by weight of Bisabolol as an active ingredient It provides a cosmetic composition comprising parts and 0.1 to 1.5 parts by weight of glutathione, wherein the weight ratio of the bisabolol and the glutathione is 1:3 to 3:1.

Description

Cosmetic composition {COSMETIC COMPOSITION}

It relates to a cosmetic composition, and more particularly, to a cosmetic composition having a skin whitening function.

In modern society, as the ozone layer is destroyed by harmful chemicals and exhaust gases, active oxygen is being generated in large quantities. These reactive oxygen species cause various side effects, and for example, they are the main cause of skin aging, pigmentation, and the like. In addition, recently, due to fine dust, etc., the skin is more easily directly exposed to pollutants during outdoor activities.

The skin acts as a primary protective layer to prevent danger from various external factors that impair the homeostasis of our body through basic metabolic processes. In other words, as the skin is located at the outermost part of the human body, it functions as a physical, chemical, and biological barrier, and performs protective functions, sensory functions, secretion and excretion functions, absorption functions, body temperature control functions, storage functions, and regeneration functions. On the other hand, it is also the first part to be damaged by continuous external stress.

The main causes of such external stress include social and work stress in addition to the above-mentioned environmental factors, and these social factors are defense caused by environmental factors such as UV exposure, exhaust gas, yellow dust, and harmful substances such as heavy metals. Creates an immune system that is vulnerable to system breakdown.

Although the elasticity and contractility of skin cells are weakened and skin wrinkles appear due to various causes, it can be largely divided into internal factor aging and external factor aging. Internal factor aging is a natural aging phenomenon that occurs due to the deterioration of the physiological functions of the skin with age. It is clinically characterized by decreased elasticity, rough skin texture, deep wrinkles, and pigmentation. External factor aging refers to aging caused by external factors such as UV rays and stress.

When the skin is exposed to UV rays, reactive oxygen species (ROS) are generated in the skin, and the excess reactive oxygen species causes oxidation to react with cell membranes, DNA, and lipids, proteins, polysaccharides and nucleic acids, which are major components of the skin. to damage the cells. Skin aging proceeds due to such cell damage.

In addition, ultraviolet light promotes the production of melanin. Melanin is the main factor that determines the color of the skin, and there are several cells that produce skin components in the basal layer of our skin. Among them, melanocytes produce melanin pigment. Because melanocytes normally produce only as much melanin as needed, the skin color is always kept the same. However, when hormones and the like are stimulated by the influence of ultraviolet rays, they produce a larger amount of melanin than usual, causing pigmentation. Melanocytes spread the melanin they have produced throughout the cells in the form of protrusions, and when these colored cells rise to the epidermal layer, the skin becomes tanned or freckles.

More specifically, melanin is synthesized in melanocytes in the epidermal layer of the skin, and in the melanosome, an organelle in melanocytes, an enzyme called tyrosinase acts on tyrosine, a type of amino acid, to dopa, It is produced through a non-enzymatic oxidation reaction after being converted to dopaquinone. When the synthesis of such melanin occurs excessively in the skin, the skin tone is darkened, and spots, freckles, and the like occur. Therefore, by inhibiting the tyrosinase activity in the skin and inhibiting the synthesis of melanin, not only can the skin tone be brightened to realize skin whitening, but also hyperpigmentation of the skin such as spots and freckles caused by UV rays, hormones, and genetic causes It can improve sedation.

As a substance capable of inhibiting the activity of such tyrosinase, various extracts including hydroquinone, ascorbic acid, kojic acid, glutathione, arbutin, and epiphyllum extract have been used, but there is a problem in the safety of the skin and the stability of the cosmetic formulation, In the case of arbutin, there is a problem that side effects that cause skin irritation appear.

One embodiment of the present invention provides a cosmetic composition that can maximize the whitening effect, and at the same time realize absorbency and spreadability that is quickly absorbed into dry skin while minimizing skin irritation.

In one embodiment of the present invention, niacinamide, glutathione, bisabolol and resveratrol are included as active ingredients, and the resveratrol relative to 100 parts by weight of the niacinamide. It provides a cosmetic composition comprising 0.001 parts by weight to 0.05 parts by weight.

The weight ratio of the bisabolol to the glutathione may be 1:2 to 2:1.

The cosmetic composition contains all of niacinamide, glutathione, bisabolol and resveratrol as active ingredients, but by containing them in a mutually appropriate relative content ratio, it is possible to maximize the whitening effect, and at the same time, absorbency and spreadability that is quickly absorbed even on dry skin It is possible to realize the advantage of minimizing skin irritation while implementing

1 (a) and (b) are pictures of before and after improvement of the neutral subjects in their 40s of Example 1, respectively.
2 (a) and (b) are pictures of before and after improvement of the neutral test subject in their 20s of Example 1, respectively.

Advantages and features of the present invention, and a method of achieving them will become clear with reference to the following examples. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various different forms, Only the present embodiments are provided so that the disclosure of the present invention is complete, and to completely inform those of ordinary skill in the art to which the present invention belongs, the scope of the invention, the present invention is defined by the scope of the claims will only be

An active ingredient referred to by a specific compound name in the present specification is understood as a concept including a predetermined substituted or modified derivative within a range that does not impair the desired effect.

In one embodiment, niacinamide, glutathione, bisabolol and resveratrol are included as active ingredients, and the amount of resveratrol is 0.001 parts by weight relative to 100 parts by weight of niacinamide. It provides a cosmetic composition comprising 15 parts by weight to 15 parts by weight.

The cosmetic composition can provide a significantly improved whitening effect compared to a case in which some of them are lacking by simultaneously including the above-mentioned four components. Specifically, the melanin production step that causes pigmentation in the skin largely proceeds in four steps. The first stage is melanin DNA synthesis stage, the second stage is melanin pigment synthesis stage, the third stage is the migration and diffusion stage of melanin, and the fourth stage is the pigmentation stage. At this time, the bisabolol mainly serves to create an environment in which the whitening effect is easy to be implemented, the resveratrol mainly plays a role in interfering with melanin and harmful factors, and the niacinamide mainly inhibits the movement of melanin pigment. It serves to prevent deposition, and the glutathione mainly serves to lighten the deposited melanin pigment. As such, the cosmetic composition has an optimized composition that prevents the progress of pigmentation by melanin in stages by containing all of the above-mentioned four components.

The cosmetic composition contains about 0.001 parts by weight to about 15 parts by weight of the resveratrol, for example, about 0.001 parts by weight to about 12 parts by weight, for example, about 0.001 parts by weight to about 100 parts by weight of the niacinamide. 10 parts by weight, such as about 0.001 parts by weight to about 5 parts by weight, such as about 0.001 parts by weight to about 1 parts by weight, such as about 0.001 parts by weight to about 0.05 parts by weight, for example, about 0.001 parts by weight to about 0.03 parts by weight, such as about 0.001 parts by weight to about 0.01 parts by weight, such as about 0.001 parts by weight to about 0.009 parts by weight, such as about 0.001 parts by weight to about 0.005 parts by weight parts, for example, about 0.001 parts by weight to about 0.004 parts by weight, for example, about 0.001 parts by weight to about 0.003 parts by weight. Conventionally, there was a limit to the application of the resveratrol to cosmetic compositions due to its own chemical stability problem. In this regard, the cosmetic composition can implement a complementary effect in terms of stability by using the resveratrol in the above-described content range relative to 100 parts by weight of the niacinamide, and as a result, effectively inhibiting melanin production in the skin function can be performed.

The cosmetic composition contains about 0.1 parts by weight to about 1.5 parts by weight of each of the bisabolol and the glutathione relative to 100 parts by weight of the niacinamide, for example, about 0.1 parts by weight to about 1.2 parts by weight, for example, about 0.1 It may include from about 1.0 part by weight to about 1.0 part by weight, for example, from about 0.1 part by weight to about 0.8 part by weight, for example, from about 0.2 part by weight to about 0.7 part by weight, for example, about 0.4 part by weight. It may contain from about 0.6 parts by weight to about 0.6 parts by weight.

The bisabolol may specifically include alpha-bisabolol. By using the bisabolol in the above-described relative content ratio compared to the niacinamide, in addition to the role of securing the environmental requirements for inhibiting melanin synthesis, it is possible to improve anti-inflammatory functions such as anti-inflammatory and antibacterial properties.

The glutathione is in the form of a tripeptide in which glutamic acid, cysteine, and glycine, which are one of the amino acids, are linked, and is a reduced substance that catches active oxygen. The glutathione effectively removes radicals in a living body and suppresses tyrosine involved in the melanin synthesis process to realize a whitening effect. The cosmetic composition can implement the antioxidant effect and the whitening effect at an excellent level at the same time by using the glutathione in the above-described relative content ratio compared to the niacinamide.

In the cosmetic composition, the weight ratio of the bisabolol to the glutathione may be from about 1:5 to about 5:1, for example, from about 1:3 to about 3:1, for example , from about 1:2 to about 2:1, for example from about 1:1.5 to 1.5:1, for example from about 1:1.2 to about 1.2:1, for example , from about 1:1.15 to about 1.15:1, for example from 1:1.10 to about 1.10:1. By using the relative weight ratio of the bisabolol and glutathione in this range, the cosmetic composition can simultaneously exhibit excellent whitening effect and anti-inflammatory function through inhibition of melanin synthesis.

The cosmetic composition may further include polyglyceryl-4 caprate as an active ingredient. The polyglyceryl-4 caprate may serve to smooth skin texture. Specifically, when the cosmetic composition further comprises polyglyceryl-4 caprate, it may contain from about 30 parts by weight to about 70 parts by weight of the polyglyceryl-4 caprate relative to 100 parts by weight of the niacinamide, for example, For example, it may contain from about 35 parts by weight to about 65 parts by weight, for example, from about 40 parts by weight to about 60 parts by weight, for example, from about 45 parts by weight to about 55 parts by weight. can When the cosmetic composition uses the polyglyceryl-4 caprate in such a content range, other components such as niacinamide, bisabolol, glutathione and resveratrol can be uniformly mixed, and It can greatly improve the spreadability and skin texture management performance.

The cosmetic composition may further include allantoin as an active ingredient. The allantoin may serve to impart cell regeneration and moisturizing effects to the cosmetic composition. Specifically, when the cosmetic composition further contains allantoin, the amount of the allantoin may be from about 1,0 parts by weight to about 10.0 parts by weight, for example, from about 1.0 parts by weight to about 8.5 parts by weight based on 100 parts by weight of the niacinamide. It may include parts by weight, for example, about 1.5 parts by weight to about 7.5 parts by weight, for example, about 2.0 parts by weight to about 6.0 parts by weight, for example, about 3.5 parts by weight parts to about 6.0 parts by weight. By using the allantoin in the cosmetic composition in such a content range, the cosmetic composition can implement an excellent moisturizing effect with a whitening effect.

The cosmetic composition may further include at least one selected from the group consisting of a moisturizing agent, a pH adjusting agent, an emollient, a viscosity adjusting agent, a chelating agent, a skin conditioning agent, a fragrance, and combinations thereof.

The type of the moisturizer is not particularly limited, but for example, propylene glycol, butylene glycol, glycerin, ceramide, sodium PCA, hyaluronic acid It may include one selected from the group consisting of ronic acid (Hyaluronic acid), cetearyl alcohol (Cetearyl alcohol), and combinations thereof.

In one embodiment, the moisturizer may include butylene glycol and glycerin as active ingredients. In this case, it may be possible to secure excellent compatibility with the combination of the active ingredients simultaneously containing the niacinamide, bisabolol, glutathione and resveratrol.

Specifically, the moisturizer may include about 20 parts by weight to about 40 parts by weight of the glycerin, for example, about 25 parts by weight to about 40 parts by weight, based on 100 parts by weight of the butylene glycol, , for example, from about 30 parts by weight to about 40 parts by weight. Accordingly, the cosmetic composition can maximize the simultaneous implementation performance of the whitening effect and the moisturizing effect.

The type of the pH adjusting agent is not particularly limited, but may include, for example, one selected from the group consisting of tromethamine, potassium hydroxide, and combinations thereof.

The type of the softener is not particularly limited, but may include, for example, one selected from the group consisting of phenyl trimethicone, glyceryl caprylate, and combinations thereof.

In one embodiment, the emollient may include phenyltrimethicone and glycerylcaprate. In this case, it may be possible to secure excellent compatibility with the combination of the active ingredients simultaneously containing the niacinamide, bisabolol, glutathione and resveratrol.

Specifically, the emollient may include about 1 part by weight to about 10 parts by weight of the glyceryl caprate based on 100 parts by weight of the phenyl trimethicone, for example, about 3 parts by weight to about 10 parts by weight. It may include, for example, about 5 parts by weight to about 10 parts by weight, for example, about 5.5 parts by weight to about 9.5 parts by weight. Accordingly, the cosmetic composition can maximize the effect of simultaneously implementing an excellent whitening effect and excellent spreadability.

The type of the viscosity enhancing agent is not particularly limited, but may include, for example, one selected from the group consisting of a carbomer, an alkyl acrylate crosslinked polymer having 10 to 30 carbon atoms, and combinations thereof.

The chelating agent is a component for preventing deterioration of cosmetic quality and rancidity, and the type thereof is not particularly limited, but may include, for example, Disodium EDTA.

The type of the skin conditioning agent is not particularly limited, but may include, for example, one selected from the group consisting of ethylhexyl glycerin, adenosine, sodium hyaluronate, and combinations thereof.

In one embodiment, the skin conditioning agent may include ethylhexylglycerin, adenosine, and sodium hyaluronate. In this case, it may be possible to secure excellent compatibility with the combination of the active ingredients simultaneously containing the niacinamide, bisabolol, glutathione and resveratrol.

Specifically, the weight ratio (A:B:C) of the ethylhexylglycerin (A), adenosine (B) and sodium hyaluronate (c) may be 1:1:1 to 3:2:1, for example For example, it may be 1:1:1 to 2.8:1.5:1, for example, 1:1:1: to 2.6:1.3:1. Accordingly, it is possible to maximize the compatibility with the combination of active ingredients containing niacinamide, bisabolol, glutathione and resveratrol simultaneously, and as a result, the whitening and moisturizing effect of the cosmetic composition can be greatly improved.

The perfume serves to provide aroma to the cosmetic composition, and the type thereof is not particularly limited, but for example, bergamot oil, spearmint leaf oil, rosewood oil, tangerine peel oil, orange peel oil, orange flower oil, It may include one selected from the group consisting of pine oil, lemon oil, cypress oil, and combinations thereof.

As specific examples of the moisturizer, pH adjuster, emollient, viscosity adjuster, chelating agent, skin conditioning agent, fragrance, etc., each component is arbitrarily classified according to its main role, and two or more roles overlapping each other in the role can be performed. For example, in the case of the disodium EDIT disclosed as a specific example of the chelating agent, as a chelate, it serves as a metal ion sequestration and the like, and may also play a role of viscosity control.

The cosmetic composition may further include a residual solvent in addition to the active ingredient. The solvent may include one selected from the group consisting of purified water, 1,2-hexanediol (1,2-Hexandiol), and combinations thereof.

The ratio of the weight of the solvent to the total weight of the active ingredient of the cosmetic composition may be from about 10:90 to about 40:60, for example, from about 10:90 to about 30:70, for example, from about 10:90 to about 20:80, for example from about 10:90 to about 15:85. When the weight ratio of the active ingredient and the solvent satisfies the above-mentioned range, the active ingredients can be uniformly mixed and dispersed, and stability can be secured without interfacial separation for a long time. Furthermore, by securing an appropriate viscosity, it is possible to achieve excellent spreadability of the cosmetic composition.

The cosmetic composition may be prepared in various formulations, for example, may be formulated as a solution, paste, gel, powder, and the like. In addition, the cosmetic composition may be applied to various uses, for example, lotion, lotion, cream, essence, cleansing foam, body wash, shampoo, conditioner, mask pack, cosmetic patch, and the like.

Hereinafter, specific embodiments of the present invention are presented. However, the examples described below are only for specifically illustrating or explaining the present invention, and the present invention is not limited thereto.

<Examples and Comparative Examples>

Example 1

Each content ratio of the active ingredients including niacinamide, glutathione, bisabolol and resveratrol is shown in Table 1 below, and 12% by weight of the active ingredient among the total weight, and a cosmetic composition containing 88% by weight of the solvent was prepared. .

active ingredient relative weight ratio Niacinamide To 100 Polyglyceryl-4 Caprate 50.000 allantoin 5.000 Ethylhexylglycerin 2.488 adenosine 2.000 Sodium Hyaluronate 0.575 bisabolol 0.500 glutathione 0.500 resveratrol 0.003 bergamot oil 0.860 spearmint leaf oil 0.260 rosewood oil 0.260 tangerine peel oil 0.260 orange peel oil 0.260 orange flower oil 0.100 tromethamine 18.000 Butylene Glycol 200.250 glycerin 75.000 Phenyltrimethicone 100.000 Glyceryl Caprylate 7.500 Carbomer 10.000 C10-30 Alkyl Acrylate Crosslinked Polymer 10.000 Disodium EDIT 1.000

Example 2 Each content ratio of the active ingredients including niacinamide, glutathione, bisabolol and resveratrol is as shown in Table 2 below, and 12 wt% of the active ingredient is included in the total weight, and 88 wt% of the solvent is prepared. did.

active ingredient relative weight ratio Niacinamide To 100 Polyglyceryl-4 Caprate 50.000 allantoin 5.000 Ethylhexylglycerin 2.488 adenosine 2.000 Sodium Hyaluronate 0.575 bisabolol 0.700 glutathione 0.300 resveratrol 0.003 bergamot oil 0.860 spearmint leaf oil 0.260 rosewood oil 0.260 tangerine peel oil 0.260 orange peel oil 0.260 orange flower oil 0.100 tromethamine 18.000 Butylene Glycol 200.250 glycerin 75.000 Phenyltrimethicone 100.000 Glyceryl Caprylate 7.500 Carbomer 10.000 C10-30 Alkyl Acrylate Crosslinked Polymer 10.000 Disodium EDIT 1.000

Example 3 Each content ratio of the active ingredients including niacinamide, glutathione, bisabolol and resveratrol is as shown in Table 3 below, and 12% by weight of the active ingredient among the total weight, and 88% by weight of the solvent To prepare a cosmetic composition did.

active ingredient relative weight ratio Niacinamide To 100 Polyglyceryl-4 Caprate 50.000 allantoin 5.000 Ethylhexylglycerin 2.488 adenosine 2.000 Sodium Hyaluronate 0.575 bisabolol 0.300 glutathione 0.700 resveratrol 0.003 bergamot oil 0.860 spearmint leaf oil 0.260 rosewood oil 0.260 tangerine peel oil 0.260 orange peel oil 0.260 orange flower oil 0.100 tromethamine 18.000 Butylene Glycol 200.250 glycerin 75.000 Phenyltrimethicone 100.000 Glyceryl Caprylate 7.500 Carbomer 10.000 C10-30 Alkyl Acrylate Crosslinked Polymer 10.000 Disodium EDIT 1.000

comparative example 1 Each content ratio of the active ingredient containing only niacinamide, glutathione and bisabolol, but not containing resveratrol is shown in Table 4 below, 12% by weight of the active ingredient among the total weight, and 88% by weight of the solvent A cosmetic composition was prepared.

active ingredient relative weight ratio Niacinamide To 100 Polyglyceryl-4 Caprate 50.000 allantoin 5.000 Ethylhexylglycerin 2.488 adenosine 2.000 Sodium Hyaluronate 0.575 bisabolol 0.500 glutathione 0.500 resveratrol - bergamot oil 0.860 spearmint leaf oil 0.260 rosewood oil 0.260 tangerine peel oil 0.260 orange peel oil 0.260 orange flower oil 0.100 tromethamine 18.000 Butylene Glycol 200.250 glycerin 75.000 Phenyltrimethicone 100.000 Glyceryl Caprylate 7.500 Carbomer 10.000 C10-30 Alkyl Acrylate Crosslinked Polymer 10.000 Disodium EDIT 1.000

<Evaluation> Experimental Example 1: Whitening effect

Korean subjects in their 20s and 40s were each 12, and the total number of subjects was 24. For the candidate candidates, skin types were classified into oily, neutral, and dry through a preliminary survey, and subjects were selected for each sample group to include one person each. Using each of the cosmetic compositions of Examples 1 to 3 and Comparative Example 1 as a sample group, 12% by weight of active ingredients and 88% by weight of solvents of the compositions shown in Table 5 below without containing niacinamide, bisabolol, glutathione and resveratrol % was used as a control. Each sample group and control group were assigned a random sample number, and a double-blind method was used so that the subject could not know the relationship between the component and the sample number. During the test period, the subject did not expose the test site to sunlight.

active ingredient relative weight ratio Niacinamide - Polyglyceryl-4 Caprate To 100 allantoin 10.000 Ethylhexylglycerin 4.976 adenosine 4.000 Sodium Hyaluronate 1.150 bisabolol - glutathione - resveratrol - bergamot oil 1.720 spearmint leaf oil 0.520 rosewood oil 0.520 tangerine peel oil 0.520 orange peel oil 0.520 orange flower oil 0.200 tromethamine 36.000 Butylene Glycol 400.500 glycerin 150.000 Phenyltrimethicone 200.000 Glyceryl Caprylate 15.000 Carbomer 20.000 C10-30 Alkyl Acrylate Crosslinked Polymer 20.000 Disodium EDIT 2.000

(1) Test site The left and right sides of the face were divided into incisors, and the sample group and the control group were applied respectively. In addition, in order to accurately recognize the selected test site during the next evaluation, a transparent mask pack was placed on the face and the positions of the eyes, nose, and mouth were marked, and then the test site was marked to evaluate the same site during the next evaluation.

(2) sample application

It was applied twice a day in the morning and evening, and a sample spoon was given to apply the same amount (30 μg) every time to all subjects.

(3) Evaluation of the test site

1) Place of measurement and evaluation

The test was conducted after taking skin stability for at least 20 minutes in a closed room that satisfies constant temperature and humidity conditions, without air movement, direct sunlight, and constant temperature and humidity.

2) Measure

Using a spectrophotometer, on the 8th week after the start of the test, the L* value of the test site was measured 3 times for each site, and the average value was measured 15 times in total as the L* value of the measurement day. After measuring each of the left and right sides of the face to which the sample group and the control group were applied, the difference value was divided by the evaluation value of the control group, and the improvement rate multiplied by 100 was used as the evaluation value.

3) evaluation

On the day corresponding to the 8th week after the start of the test, 3 experts for the test site of the test subject were visually evaluated on which of the scores in 0.5-point units from 0 (bright and clear) to 9 (dark and dull). , each of the left and right sides of the face applied with the sample group and the control group were evaluated and scored. Each score was taken as the average value of the scores of the highest scorer and the lowest scorer among experts, and the difference between the sample group and the control group was used as the evaluation value.

The results for each of the above-described evaluations are shown in Table 6 below.

sample group skin
type L* evaluation result Visual evaluation results 20's 40's 20's 40's Improvement (%) Average (%) Improvement (%) Average (%) difference average difference average Example 1 inattention 3.50 4.05 2.95 3.16 1.50 1.67 1.00 1.17 neutrality 4.65 4.18 2.00 1.50 Intelligence 3.99 2.34 1.50 1.00 Example 2 inattention 1.66 2.73 1.34 1.53 1.00 1.17 0.50 0.92 neutrality 2.81 2.10 1.00 1.50 Intelligence 3.73 1.16 1.50 0.75 Example 3 inattention 1.22 1.44 1.91 1.38 0.00 0.33 1.25 1.00 neutrality 1.47 0.90 0.50 1.50 Intelligence 1.62 1.33 0.50 0.25 Comparative Example 1 inattention 1.32 1.12 0.36 0.89 0.50 0.50 0.00 0.08 neutrality 0.60 1.21 0.00 0.25 Intelligence 1.45 1.08 1.00 0.00

Considering the L* improvement rate and the visual evaluation value of Table 6, in the case of Example 1, including all of niacinamide, bisabolol, glutathione and resveratrol, the relative content ratio of niacinamide and resveratrol By satisfying a predetermined range, it was confirmed that the whitening effect was significantly superior to that of Comparative Example 1. In addition, in the case of Example 1, it was confirmed that the glutathione and the bisabolol satisfies a specific relative content ratio, thereby achieving a significantly superior whitening effect compared to Examples 2 and 3.

1 (a) and (b) are pictures of before and after improvement of the neutral subjects in their 40s of Example 1, respectively. In addition, (a) and (b) of FIG. 2 are pictures of the before and after improvement of the neutral test subject in their twenties of Example 1, respectively. 1 and 2 , it was confirmed that spots and freckles were eliminated through the cosmetic composition of Example 1 to realize an excellent whitening effect.

Experimental Example 2: Skin irritation

(1) Evaluation method

For 30 sensitive subjects, the cosmetic composition of Example 1 was subjected to a 24-hour closed patch test (Closed Chamber Test). It was carried out for a total of 4 days, and the sample was carried out in 20mL X 2EA. Visual evaluation by a dermatologist was evaluated based on the standards of the Society for Contact Dermatitis (ICDRG) and the standards of the American Cosmetics Association (PCPC).

(2) Evaluation results

With a skin irritation index of 0.00, it was judged as a non-irritating product according to the criteria.

According to the results of Experimental Example 2, it was confirmed that, in the case of the cosmetic composition of Example 1, an excellent whitening effect was realized as shown in Experimental Example 1, and an effect of no skin irritation was realized at the same time.

Claims (8)

100 parts by weight of niacinamide as an active ingredient;
Resveratrol (Resveratrol) 0.001 parts by weight to 0.03 parts by weight;
0.1 to 1.5 parts by weight of Bisabolol; and
Glutathione (Glutathione) 0.1 to 1.5 parts by weight; including,
The weight ratio of the bisabolol and the glutathione is 1:3 to 3:1,
cosmetic composition.
According to claim 1,
The weight ratio of the bisabolol and the glutathione is 1:2 to 2:1,
cosmetic composition.
According to claim 1,
Purified water, including one selected from the group consisting of 1,2-hexanediol (1,2-hexandiol) and combinations thereof as a solvent,
cosmetic composition.
According to claim 1,
Further comprising polyglyceryl-4 caprate as the active ingredient,
Further comprising 30 parts by weight to 70 parts by weight of the polyglyceryl-4 caprate relative to 100 parts by weight of the niacinamide,
cosmetic composition.
According to claim 1,
Further comprising allantoin (Allantoin) as the active ingredient,
Containing 1.0 parts by weight to 10.0 parts by weight of the allantoin relative to 100 parts by weight of the niacinamide,
cosmetic composition.
According to claim 1,
Moisturizer, pH adjuster, emollient, viscosity enhancing agent, chelating agent, skin conditioning agent, further comprising at least one selected from the group consisting of fragrances and combinations thereof,
cosmetic composition.
7. The method of claim 6,
The moisturizer includes butylene glycol and glycerin as active ingredients,
Comprising 20 parts by weight to 40 parts by weight of the glycerin relative to 100 parts by weight of the butylene glycol,
cosmetic composition.
7. The method of claim 6,
The emollient includes phenyltrimethicone and glycerylcaprate,
Comprising 1 part by weight to 10 parts by weight of the glyceryl caprate relative to 100 parts by weight of the phenyl trimethicone,
cosmetic composition.

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