KR102273879B1 - Hair treatment composition for reducing malodor of permed hair and improving long-lasting effect and hair treatment agent comprising the same - Google Patents

Abstract

The present invention provides a composition for hair treatment comprising at least one compound selected from the group consisting of a maleimide compound, a haloacetyl compound, and a pyridyl disulfide compound, the composition for reducing perm odor or improving perm lasting power, and a hair treatment agent comprising the same do. Preferably, the composition for hair treatment and the hair treatment agent of the present invention may include all of the maleimide compound, the haloacetyl compound, and the pyridyl disulfide compound, and in this case, it is possible to obtain a more excellent perm odor reduction and perm lasting effect.

Description

Hair treatment composition for reducing malodor of permed hair and improving long-lasting effect and hair treatment agent comprising the same

The present invention relates to a composition for hair treatment and a hair treatment agent comprising the same. More particularly, the present invention relates to a composition and treatment agent for hair treatment that reduces the smell of perm generated after perm treatment and at the same time improves the durability of the perm effect.

In general, hair is an appendage of the skin of mammals, and it is a keratinized structure formed by inclusion of the epithelium of the epidermis embryologically, and corresponds to an appendage of the skin along with sweat and sebaceous glands. Hair includes all hairs covering the outside of the human body, such as hair, downy hair, beard, armpit hair, and pubic hair, and in some cases, refers only to the hair on the scalp.

Hair is composed of keratin protein, which is the same as the main component of the stratum corneum of the skin, and keratin is largely divided into two types according to its origin. . This is a difference according to the content of cysteine, one of the amino acids. Hard keratin has a high content and soft keratin has a low content. Therefore, hard keratin has a strong resistance to external stimuli or invasion of chemicals.

Hair fibers are about 50-100 ㎛ thick and are composed of cuticle called hair cortex and cortex called cortex, and sometimes have metula called medulla in the middle. All of these cells are dead cells, mostly filled with keratin protein.

About 65-95% of human hair is composed of keratin protein, and contains water, lipids (bound and unbound forms), pigments, and trace elements. Proteins are made from mixtures of about 20 to 50 amino acids to form long chains. Each chain is wound into a spiral or coil.

Among the numerous amino acids that make up human hair, cystine is one of the most important amino acids. Cystine is composed of two cysteines (thiols) present in different amino acid chains, and forms a disulfide bond, known as a very strong bond, that forms a bond between two sulfur atoms in a state of being close to each other. are doing In addition to disulfide bonds, hair contains very abundant peptide bonds. In addition, the presence of many CO- and NH- groups causes hydrogen bonds between neighboring chain molecular groups. However, the physical properties of the hair appear due to the high cystine content, which is a very unique part of the cellular structure of human hair. The pigment, which is related to the color of hair, is melanin, which is mainly present in the form of granules in the cortex of human hair.

Most of the hair is protein, and the rest are melanin, lipids, trace elements, and moisture. The protein that makes up most of the amino acid composition of hair is keratin protein, which contains a lot of cysteine. Hair keratin is composed of about 18 amino acids, and in its composition, the content of cysteine is higher than that of the human epidermis. In addition, the ratio of histidine, lysine, and arginine, which are basic amino acids, is 1:3:10, which is unique to hair keratin. Skin collagen is free of cysteine and is instead high in glycine, proline, and alanine. The melanin pigment, which determines the color of hair, is contained in hair at about 3% or less.

In addition to protein and melanin pigment, hair contains minerals and trace elements such as copper, zinc, iron, manganese, calcium, and magnesium, and it is known that inorganic components such as phosphorus, silicon, and the like exist. The amount of trace elements present in the hair is known to be about 0.55 to 0.94% of the hair ash. The amount of lipid present in the hair varies from person to person, but it is present in about 1 to 9%. The lipids present in the hair are divided into the surface lipids derived from the sebaceous glands and the lipids present in the hair, as in the skin, but the difference in the composition of the lipids derived from the outside and the inside of the hair is not large, and the free fatty acid content is the highest. This large remainder is known to be triglycerides (wax, glycerides, cholesterol, squalene). And most of the lipids are polar lipids.

In the hair bond, in addition to the peptide bond between the amino acids in the protein, there is an intermolecular force or binding force between each protein molecule, and by this bond, the hair maintains its properties and shape. Types of bonds are broadly cross-linked cystine bonds and peptide bonds, and non-cross-linked salt bonds, hydrogen bonds, and hydrophobic interactions. Among them, the cystine bond (Disulfide Bond; -CH2-S-S-CH2-) is uniquely shown in a protein containing sulfur (S), a side chain bond not seen in other fibers, and a bond characteristically shown in keratin. With this cystine bond, keratin exhibits strong physicochemical properties.

Such hair plays a very important decorative role in the modern society that allows people to pursue their individuality and express their beauty.

Reflecting these characteristics, various treatments for hair, such as dyeing, perming, and coating, are being performed for the purpose of maintaining the shape of the hair beautifully and making it easier to manage. Among them, the permanent wave, also called permanent wave, first uses a reducing agent such as thioglycolic acid, ammonium thioglycolate, thioglycolic acid monoethanolamine, cysteine hydrochloride, cysteinamine, sodium thioglycolate, etc. to break the cystine bond in the hair keratin component. It is one of the hair treatments that uses the principle of reconnecting the cystine bond by using an oxidizing agent such as sodium bromate, potassium bromate, or hydrogen peroxide after cutting the hair to the desired shape.

However, after such a cystine reduction type perm treatment, a perm odor that is perceived as a very bad odor emotionally is generated due to cysteine that is not reunited by the residual reducing agent and the oxidizing agent, and the part that has been permed by the residual reducing agent is reduced or not combined again. There is also a problem that the permanent effect does not last long due to problems such as the presence of a large number of cysteines that are not available.

Accordingly, an object of the present invention is to provide a hair treatment composition and a hair treatment agent comprising the same for solving the above problems, reducing the perm odor remaining after perming, and improving the durability of perm.

An object of the present invention is to provide a combination of compounds that can provide a more improved perm odor improvement effect and perm lasting power than when used alone in a composition.

In addition, the present invention provides a novel use of a composition for hair treatment for improving perm odor and improving perm durability by using a combination of the above compounds.

In order to solve the above problems, the present invention provides a hair treatment composition comprising any one or more compounds selected from the group consisting of maleimide compounds, haloacetyl compounds, and pyridyl disulfide compounds, and hair treatment agents comprising the composition .

The inventors of the present invention have been able to reduce the perm odor remaining after the permanent wave treatment (hereinafter referred to as perm treatment) due to the treatment of products for perm with a strong odor, and as a result of continuous research to improve the durability of perm after perm treatment The present invention has been completed.

The inventors of the present invention, as a result of treating a composition containing any one or more compounds selected from the group consisting of a maleimide compound, a haloacetyl compound, and a pyridyl disulfide compound, after the perm treatment, the effect of reducing the perm odor and improving the perm lasting power It was confirmed that there is

As used herein, the maleimide compound refers to a compound having a maleimide group in the compound, and may be represented by the following Chemical Formula 1.

<Formula 1>

The maleimide compound is n-Arm polyoxyethylene maleimide (n is an integer of 2 to 8), N-(α-maleimidoacetoxy)-succinimide ester (N-(α-Maleimidoacetoxy) -succinimide ester), 1,4-bis-maleimidobutane (1,4-Bis-Maleimidobutane), bis-maleimidohexane, bis-maleimidoethane, N-(β -maleimidopropionic acid)hydrazide?TFA(N-(β-Maleimidopropionic acid)hydrazide?TFA), N-(β-maleimidopropyloxy)succinimide ester (N-(β-Maleimidopropyloxy)succinimide ester), 1 ,8-bis-maleimidoethane (diethylene-glycol (1,8-Bis-Maleimidodiethylene-glycol), 1,11-bis-maleimidotriethylene glycol (1,11-Bis-Maleimidotriethyleneglycol), dithio-bis -Maleimidoethane (Dithio-bis-maleimidoethane), N-ε-maleimidocaproic acid (N-ε-Maleimidocaproic acid), N-(ε-maleimidocaproic acid) hydrazide (N-(ε-Maleimidocaproic acid) hydrazide), N-(ε-Maleimidocaproyloxy)succinimide ester), N-(γ-maleimidobutyryloxy)succinimide ester (N-(γ-maleimidocaproyloxy)succinimide ester) -Maleimidobutyryloxy)succinimide ester), N-κ-maleimidoundecanoic acid (N-κ-Maleimidoundecanoic acid), succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxyl-(6-amidocapro) ate) (Succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxy-(6-amidocaproate)), m-maleimidobenzoyl-N-hydroxysuccinimi De ester (m-Maleimidobenzoyl-N-hydroxysuccinimide ester), 4-(4-N-maleimidophenyl)-butyric acid hydrazide?HCI(4-(4-N-Maleimidophenyl)-butyric acid hydrazide?HCI), N -(p-Maleimidophenyl)isocyanate (N-(p-Maleimidophenyl)isocyanate), succinimidyl 4-(N-maleimido-methyl)cyclohexane-1-carboxylate (Succinimidyl 4-(N-maleimido-methyl) )cyclohexane-1-Carboxylate), succinimidyl-6-(β-maleimidopropionamido)hexanoate (Succinimidyl-6-(β-maleimidopropionamido)hexanoate), succinimidyl 4-(p-maleimido- Succinimidyl 4-(p-maleimido-phenyl)butyrate), N-(ε-maleimidocaproyloxy)sulfosuccinimide ester (N-(ε-Maleimidocaproyloxy)sulfosuccinimide ester), N-(γ- Maleimidobutryloxy)sulfosuccinimide ester (N-(γ-Maleimidobutryloxy)sulfosuccinimide ester), N-(κ-maleimidoundecanoyloxy)sulfosuccinimide ester (N-(κ-Maleimidoundecanoyloxy)sulfosuccinimide ester) ), m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester (m-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester), sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfosuccinimidyl) 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), sulfosuccinimidyl 4-(p-maleimidophenyl)butyrate), tris-(2-maleimidoethyl)amine (Tris-(2-Maleimidoethyl)amine (T rifunctional)) and n-hydroxysuccinimide ester-(PEG)n-maleimide (n-Hydroxysuccinimide ester-(PEG)n-Maleimide) (n is an integer from 2 to 100) It is preferably any one selected from n-Arm polyoxyethylene maleimide (n is an integer of 2 to 8) and 1,11-bis-maleimidotriethylene glycol, and most preferably n-Arm polyoxyethylene maleimide ethylene maleimide.

As used herein, the haloacetyl compound refers to a compound having a haloacetyl group in the compound, and Formula 2 below represents an iodine-substituted acetyl compound. The haloacetyl compound refers to an acetyl group substituted with iodine (I), bromine (Br), fluorine (F) or chlorine (Cl).

<Formula 2>

The haloacetyl compound is 2-[N2-(4-azido-2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]ethylmethanethio Sulfate (2-[N2-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]ethylmethanethiosulfate), 2-{N2-[N6-(4-azi Figure-2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]ethylmethanethiosulfate (2-{N2-[N6-(4-Azido -2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]}ethylmethanethiosulfate), succinimdyl 3-(bromoacetamido)propionate (Succinimdyl 3-(bromoacetamido) propionate), N-succinimidyl iodoacetate, N-succinimidyl (4-iodoacetyl) aminobenzoate (N-Succinimidyl (4-iodoacetyl) aminobenzoate), and sulfosuccinimidyl (4-iodo-acetyl) aminobenzoate (Sulfosuccinimidyl(4-iodo-acetyl)aminobenzoate) may be at least one selected from the group consisting of, preferably N-succinimidyl iodoacetate, N-succinimidyl (4-iodoacetyl)aminobenzoate and sulfosuccinimidyl(4-iodo-acetyl)aminobenzoate, most preferably N-succinimidyl iodoacetate and N-succinimidyl (4-iodoacetyl) any one selected from aminobenzoate.

As used herein, the pyridyl disulfide compound refers to a compound having a pyridyl disulfide group in the compound, and Formula 3 below represents a pyridyl disulfide compound substituted with an R group.

<Formula 3>

The pyridyl disulfide compound is N-(4-[ρ-azidosalicylamido]butyl)-3'-(2'-pyridyldithio)propionamide (N-(4-[ρ-Azidosalicylamido]butyl) -3'-(2'-pyridyldithio)propionamide), 1,4-di-(3'-[2'-pyridyldithio]propionamido)butane (1,4-Di-(3'-[2) 'pyridyldithio]propionamido) butane), succinimidyl 6-(3'-[2-pyridyldithio]propionamido)hexanoate), 3-(2-pyridyldithio)propionylhydrazide (3-(2-Pyridyldithio)propionylhydrazide), 4-succinimidyloxycarbonyl-methyl-α-(2-pyridyldithio)toluene (4- Succinimidyloxycarbonyl-methyl-α-(2-pyridyldithio)toluene), N-succinimidyl 3-(2-pyridyldithio)propionate (N-Succinimidyl 3-(2-pyridyldithio)propionate), sulfosuccinimidyl 6-(α-methyl-α-[2-pyridyldithio]-toluamido)hexanoate (Sulfosuccinimidyl 6-(α-methyl-α-[2-pyridyldithio]-toluamido)hexanoate), sulfosuccinimidyl Diyl 6-3'-[2-pyridyldithio]propionamido)hexanoate (Sulfosuccinimidyl 6-(3'-[2-pyridyldithio]propionamido)hexanoate) and sulfo-NHS-(2-6-[biotin) amido]-2-(p-azidobezamido) (Sulfo-NHS-(2-6-[Biotinamido]-2-(p-azidobezamido)) may be at least one selected from the group consisting of, preferably may be selected from N-succinimidyl 3-(2-pyridyldithio)propionate and succinimidyl 6-(3'-[2-pyridyldithio]propionamido)hexanoate, Most preferably N-succinimidyl 3-(2-pyridyldithio)propionate.

In Formulas 1 to 3, R is hydrogen or an alkyl having 1 to 24 carbon atoms, polyoxyethylene and/or polyoxypropylene having 1 to 100 repeating units, and a polysiloxane structure having 1 to 100 repeating units, and these alkyl, poly Hydrogen, alkyl, aromatic compounds, nitrogen compounds, cationized compounds, oxygen compounds and the like may be substituted for the main chain carbon and silicon molecules of oxyethyl, polyoxypropyl and polysiloxane.

In addition, the maleimide compounds, haloacetyl compounds, and pyridyl disulfide compounds used in the present invention may contain at least 1 to 8 maleimide, haloacetyl, and pyridyl disulfide residues in the same molecule.

The inventors of the present invention have found that, compared to the case of including the maleimide compound, the haloacetyl compound, and the pyridyl disulfide compound, a more excellent effect of reducing perm odor can be obtained when all of them are included, and the durability of the perm is also longer than when the maleimide compound, the haloacetyl compound, and the pyridyl disulfide compound are included. got to confirm the facts.

When a maleimide compound, a haloacetyl compound, and a pyridyl disulfide compound were used simultaneously, a synergistic effect could be obtained due to their interaction.

That is, as a result of the simultaneous treatment of the three types of compounds, it was confirmed that the degree of strong odor irritating the nose was reduced after the perm treatment, and the degree of stimulation of the smell was significantly reduced to the extent that the operator did not feel objectionable. In particular, when the three kinds of compounds were treated alone, the degree of stimulation was small, but the three kinds of compounds induced a synergistic effect, and the operator was able to obtain greater satisfaction.

Permanent odor as used herein means an unpleasant odor remaining on the operator's hair, scalp, etc. after the perming procedure. This perm odor is caused by the use of a reducing agent for perm treatment, and it also means a bad irritating odor from the product for perm, and even the smell of a modified perm product from a person who has undergone perm treatment after perm treatment. used as a broad concept.

As used herein, the improvement in the persistence of the perm means that the shape retention is improved and the phenomenon in which the perm returns to the state before the procedure is reduced. As the durability of the perm is improved, the degree of sagging of the hair after the procedure is reduced.

In general, the durability of a perm can be measured using a curl tension evaluation method.

The composition for hair treatment of the present invention may further include ingredients that may be included in the composition for hair treatment in addition to the above compounds. For example, oil, wax, hydrocarbon, higher fatty acid, higher alcohol, ester oil, silicone oil, etc., anionic, cationic, amphoteric, nonionic surfactant, humectant, thickener, and film forming agent. It may contain compounds, UV absorbers and blockers, antioxidants, sequestering agents, coloring materials including dyes and pigments, fragrances, preservatives, and the like.

The type of the oil is not particularly limited, and for example, hydrocarbon-based oils such as squalane and liquid paraffin, and vegetable oils such as macadamia nut oil and olive oil may be used.

As the wax, polyethylene, ceresin wax, candelilla wax, microcrystalline wax, cowbana wax, beeswax wax, a higher alcohol having a degree of carbon polymerization of 20 or more may be used alone or in combination of two or more.

The component included in the composition for hair treatment is not particularly limited as long as it is a component included in the composition for non-aqueous hair treatment.

That is, since there is a risk of inhibiting the effect of a functional group having reactivity due to the nature of the present invention, preferably, an aqueous raw material is not included.

The hair composition of the present invention includes fatty acids such as palmitic acid and stearic acid, fatty alcohols, cationized surfactants such as straight or branched long-chain alkyl quaternary ammonium salts, cationized cellulose, Formulation can be facilitated when mixed with a derivative having a cationized cosmetic function, such as cationized guar and cationized polyvinylpyrrolidone, a derivative having a functional group, silicone, and the like. In addition, for formulation into cosmetic formulations, solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusters, metal ion sequestrants, colorants, pearlizing agents, appearance improving agents, pigments, powder particles, etc. Ingredients for cosmetic formulation may be included incidentally.

The present invention also provides a hair treatment agent or hair treatment product comprising the composition for hair treatment of the present invention.

Examples of application of hair products include shampoos, pre-shampoo products, rinses, treatments, waxes, sprays, mousses, lotions, essences, creams, permanent hair dyes, temporary hair dyes, and perms. It may contain agents.

More preferably, the inventors of the present invention have confirmed that the hair treatment product of the present invention may lose its activity in the water-soluble preparation because it contains a compound containing a functional group having reactivity.

Therefore, the reaction can occur by mixing with a buffer solution for pH adjustment immediately before use, by contacting water during the washing process, or by mixing when used in two or more formulations. As the formulation of the hair treatment product of the present invention, a liquid type, sheet type, powder powder type, tablet type, oil, wax, ampoule, gel, etc. used as conventional non-aqueous cosmetic preparations may be used.

The present invention reduces the perm odor remaining after perm. It provides an excellent feeling of use to users by alleviating discomfort that may be caused by strong stimulation of the existing perm odor.

In addition, the composition of the present invention has improved perm holding power and lasting power so that the effect after perm can be maintained for a long time.

In the present invention, when all of the maleimide, haloacetyl, and pyridyl disulfide compounds are included, it is possible to obtain an improved effect of improving perm odor and improving hair durability, which could not be obtained with only one of the compounds.

Hereinafter, the following examples and the like will be described in order to explain the present invention in more detail. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided by way of example to help the specific understanding of the present invention.

Preparation of lotion-type composition

First, a buffer solution is prepared with the composition shown in Table 1 below, and cetostearyl alcohol and Ceteareth-20 are added to this solution, heated to 65° C., stirred for 20 minutes, and then cooled. Then, the composition of Table 1 was prepared by adding the additionally added material at 40° C. or less and stirring for 30 minutes.

(weight%) ratio
school
Yes
One room
city
Yes
One room
city
Yes
2 room
city
Yes
3 room
city
Yes
4 room
city
Yes
5 room
city
Yes
6 room
city
Yes
7 room
city
Yes
8 room
city
Yes
9 Example 10 Example 11 Example 12 KH2PO4 / NaOH Buffer (pH 7.0) 91.20 90.20 90.20 90.20 90.20 90.20 90.20 90.70 88.20 91.20 91.20 90.86 90.87 Cetostearyl Alcohol 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 Ceteareth-20 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 Propylene Glycol 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 NHS-PEG8-Maleimide - 1.00 - - - - - - - - - - - Bis
Maleimido
butane - - 1.00 - - - - - - - - - - Bis
Maleimido
triethyleneglycol - - - 1.00 - - - - - - - - 0.2 4-Arm PEG(3Mole) Maleimide - - - - 1.00 - - 0.50 3.00 - - - - 6-Arm PEG(3Mole) Maleimide - - - - - 1.00 - - - - - - - 8-Arm PEG(3Mole) Maleimide - - - - - - 1.00 - - - - 0.2 - N-Succinimidyl
(4-iodoacetyl)
aminobenzoate - - - - - - - - - 1.00 - 0.2 0.2 Succinimidyl 6-(3'-
[2-pyridyldithio]
propionamido)hexanoate - - - - - - - - - - 1.00 0.1 0.1 Sum 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00

Assessment Methods

The prepared lotion-type hair treatment composition was applied evenly to the hair that had been permed before shampooing for each of 15 subjects who had undergone reduced perming, and left for 3 minutes before shampooing. Satisfaction with perm odor reduction and shape maintenance durability was evaluated after 3 days of perm.

(1) Evaluation of perm odor reduction

The degree of perm odor felt after 3 days compared to the perm odor felt by the operator who received the perm treatment was evaluated on a 5-point scale.

(2) Evaluation of perm shape maintenance durability

Perm shape maintenance durability was evaluated using the curl tension evaluation method.

Specifically, the initial length was measured and recorded in the state in which the perm was formed. Next, the operator's satisfaction with the shape change of the hair after 3 days was evaluated on a 5-point scale compared to the shape shown after shampooing, perming, and complete drying after treatment with the compositions of Examples 1 to 12 and Comparative Examples.

Evaluation results

As a result of examining the comparative examples and examples of the present invention, it was confirmed that the composition of the present invention has significantly improved perm odor reduction effect and perm lasting effect compared to the case where the compounds of the present invention are not included.

In particular, it was confirmed that the more the structure capable of binding to cysteine was included, the greater the effect was.

In Examples 11 and 12, when all three types having a maleimide, haloacetyl, and pyridyl disulfide structure were included, both the perm odor reduction effect and the perm lasting effect received good evaluation scores compared to the case of using alone. .

Therefore, it was confirmed that the compounds having the maleimide, haloacetyl, and pyridyl disulfide structures exhibited more excellent effects due to the synergistic effect of the compounds through the above results.

The results are shown in Table 2 below.

effect
(satisfaction 5-point scale) Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 room
city
Example 9 Example 10 Example 11 Example 12 Reduce perm odor 2.8 4.0 4.2 4.2 4.3 4.3 4.3 3.8 4.3 4.4 3.8 4.6 4.5 Perm Durability 2.5 3.6 4.2 4.3 4.2 4.4 4.4 3.6 4.3 4.4 3.6 4.7 4.6

According to the results of Table 2, in the case of Examples 11 and 12, in which maleimide, haloacetyl, and pyridyl disulfide compounds were simultaneously used, the permer compared to Example 7 in which the same amount of 4-Arm PEG (3Mole) Maleimide was used. It was confirmed that the odor reduction effect was more excellent, and the perm durability was also more excellent.

In addition, in Examples 11 and 12, by using a maleimide, haloacetyl, and pyridyl disulfide compound at the same time, Examples 3 to 6 using only any one of the maleimide, haloacetyl, and pyridyl disulfide compounds and 9 to 10, even though only half the amount was used, a similar effect could be exhibited.

Therefore, in the case of a composition using the maleimide, haloacetyl, and pyridyl disulfide compounds of the present invention simultaneously, it was confirmed that the object of the present invention can be effectively achieved.

Claims (7)

Containing any one or more compounds selected from the group consisting of maleimide compounds, and pyridyl disulfide compounds,
Hair composition for reducing perm odor. The method of claim 1, wherein the maleimide compound is n-Arm polyoxyethylene maleimide (n is an integer of 2 to 8), N-(α-maleimidoacetoxy)-succinimide ester, 1,4-bis -maleimidobutane, bis-maleimidohexane, bis-maleimidoethane, N-(β-maleimidopropionic acid)hydrazide TFA, N-(β-maleimidopropyloxy)succinimide ester, 1,8- Bis-maleimidoethane (diethylene-glycol, 1,11-bis-maleimidotriethylene glycol, dithio-bis-maleimidoethane), N-(ε-maleimidocaproic acid) hydra Zide, N-(ε-maleimidocaproyloxy)succinimide ester, N-(γ-maleimidobutyryloxy)succinimide ester, N-κ-maleimidoundecanoic acid, succinimidyl 4-( N-maleimidomethyl) cyclohexane-1-carboxy-(6-amidocaproate), m-maleimidobenzoyl-N-hydroxysuccinimide ester, 4-(4-N-maleimidophenyl)-buty Ric acid hydrazide HCI, N-(p-maleimidophenyl)isocyanate, succinimidyl 4-(N-maleimido-methyl)cyclohexane-1-carboxylate, succinimidyl-6-(β-maleimidopropion amido)hexanoate, succinimidyl 4-(p-maleimido-phenyl)butyrate, N-(ε-maleimidocaproyloxy)sulfosuccinimide ester, N-(γ-maleimidobutryloxy) Sulfosuccinimide ester, N-(κ-maleimidoundecanoyloxy)sulfosuccinimide ester, m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester, sulfosuccinimidyl 4-(N-malei) Midomethyl)cyclohexane-1-carboxylate, sulfosuccinimidyl 4-(p-maleimidophenyl)butyrate, tris-(2-maleimidoethyl)amine and n-hydroxysuccinimide ester-(PEG)n - A hair composition for reducing perm odor, characterized in that at least one selected from the group consisting of maleimide (n is an integer of 2 to 100). delete According to claim 1, wherein the pyridyl disulfide compound is N-(4-[ρ-azidosalicylamido]butyl)-3'-(2'-pyridyldithio)propionamide, 1,4-di- (3'-[2'-pyridyldithio]propionamido)butane, succinimidyl 6-(3'-[2-pyridyldithio]propionamido)hexanoate, 3-(2-pyri Dildithio)propionylhydrazide, 4-succinimidyloxycarbonyl-methyl-α-(2-pyridyldithio)toluene, N-succinimidyl 3-(2-pyridyldithio)propionate , sulfosuccinimidyl 6-(α-methyl-α-[2-pyridyldithio]-toluamido)hexanoate, sulfosuccinimidyl 6-3'-[2-pyridyldithio]propionami Figure) Hexanoate and sulfo-NHS-(2-6-[biotinamido]-2-(p-azidobenzamido) hair composition for reducing perm odor, characterized in that at least one selected from the group consisting of . According to claim 1, wherein the composition further comprises a haloacetylated compound, the hair composition for reducing perm odor comprising all of a maleimide compound, a haloacetyl compound, and a pyridyl disulfide compound. 6. The composition of claim 5, wherein the composition comprises n-Arm polyoxyethylene maleimide, N-succinimidyl (4-iodoacetyl)aminobenzoate, and N-succinimidyl 3-(2-pyridyldithio). A hair composition for reducing perm odor, comprising propionate together. A hair treatment agent for reducing perm odor, comprising the hair composition according to any one of claims 1 to 2 and 4 to 6 .