KR102272242B1 - liposome cosmetic composition, oil base composition comprising the same - Google Patents

Abstract

The present invention relates to a liposome cosmetic composition, an oily base composition comprising the same, an oily base composition comprising the same, and a customized cosmetic composition based thereon.

Description

Liposome cosmetic composition, oil base composition comprising the same

The present invention relates to a liposome cosmetic composition, an oily base composition comprising the same, an oily base composition comprising the same, and a customized cosmetic composition based thereon.

It has been reported that ceramide is the most important lipid for keratinocyte intercellular lipids, and when its concentration is decreased, the protective barrier function of the stratum corneum is reduced, and various dermatological symptoms such as atopic dermatitis and psoriasis symptoms appear. For this purpose, many attempts have been made to apply ceramide to cosmetics, but ceramide is fat-soluble or sparingly soluble and does not dissolve in water, so it cannot be used in water-based cosmetics such as skin that consists only of water. Many technologies are being developed for However, the previously developed ceramide liposome (hereinafter referred to as 'cerosome') technology may be stable by itself, but when mixed with a water-soluble cosmetic such as skin, precipitation of the ceramide encapsulated in the liposome appears. skills are required for

In addition, when a large amount of oil as well as ceramides is contained in the cerosome, it is applied to water-soluble cosmetics such as skin to increase the moisturizing and suppleness of the skin. However, preparing the liposome by containing a large amount of oil as well as ceramide in the liposome increases the hydrophobicity of the inner phase and causes a problem in that stability is inhibited, such as phase inversion to W/O.

Therefore, an object of the present invention is to provide a liposome cosmetic composition with improved stability by preventing the release of ceramide and oil present in the liposome, and preventing coalescence between liposome particles while increasing the moisturizing and softness of the skin of the liposome containing a large amount of ceramide oil in the liposome. will provide

Another object of the present invention is to provide an oily base of a customized cosmetic composition that can maintain stability while containing a large amount of oil as an oily base of a customized cosmetic composition for manufacturing cosmetics customized to the user according to the user's skin type.

In order to achieve the object of the present invention, the present invention is a ceramide; oil; a surfactant of Formula 1; organic solvents; anionic surfactants; and water; and a liposome cosmetic composition comprising

[Formula 1]

The oil comprises 20% to 60% by weight of the total composition,

The anionic surfactant provides at least one liposome cosmetic composition selected from the group consisting of surfactants of Formula 2, Formula 3, and Formula 4.

[Formula 2]

A is an alkyl chain, and n is an integer from 12 to 18. B is a salt wherein M is a group 1 metal.

[Formula 3]

A is an alkyl chain, and n is an integer from 12 to 18.

B is a salt wherein M is a group 1 metal.

[Formula 4]

A is an alkyl chain, and n is an integer from 12 to 18.

B is a salt wherein M is a group 1 metal.

In the compounds of Formulas 2 to 4, M is preferably sodium or potassium.

According to an embodiment of the present invention, the oil is preferably included in an amount of 30% to 50% by weight of the total weight of the liposome cosmetic composition.

According to one embodiment of the present invention, the oils are triglyceride-based oils of vegetable origin, such as olive oil, grape seed oil, corn oil, macadamia oil, meadowfoam oil, and esters of C8-C30 fatty acids with guerbet alcohol, particularly octyl dodecanol and octyldodecanol esters such as octyldodecyl myristate; and mixtures thereof may be used. Also synthetic esters and ethers, in particular esters and ethers of fatty acids and/or fatty alcohols, for example oils of the _{formulas R 1} COOR ₂ and R ₁ OR _{2 , wherein R 1} CO represents a fatty acid residue or R ₁ is represents a fatty alcohol residue having 8 to 29 carbon atoms, and R ₂ represents a branched or unbranched hydrocarbon-based chain having 3 to 30 carbon atoms), for example 2-octyldodecyl stearate, 2-octyldodecyl erucate or isostearyl isostearate; Hydroxylated esters such as isostearyl lactate, octyl hydroxystearate, octyldodecyl hydroxystearate, diisostearyl maleate, triisocetyl citrate, and fatty alcohols heptanoate, octano 8 and decanoate; polyol esters such as propylene glycol dioctanoate, neopentyl glycol diheptanoate and diethylene glycol diisononanoate; and pentaerythritol esters such as pentaerythrityl tetraisostearate; and mixtures thereof; may be used.

According to an embodiment of the present invention, the ceramide is from the group consisting of ceramide EOP (Ceramide EOP), ceramide NS (Ceramide NS), ceramide NP (Ceramide NP), ceramide AS (Ceramide AS) and ceramide AP (Ceramide AP) It is preferable that it is 1 or more types selected.

According to an embodiment of the present invention, the organic solvent is preferably a mixture of at least one selected from the group consisting of glycerin, 1,3-butylene glycol, dipropylene glycol, and propylene glycol.

According to an embodiment of the present invention, the surfactant of Formula 1 is preferably selected from the group consisting of phospholipids containing a glycerol phosphate group.

According to an embodiment of the present invention, it is preferable that the at least one anionic surfactant selected from Formulas 2 to 4 is 0.1 wt% to 5 wt% of the total weight of the liposome cosmetic composition.

According to an embodiment of the present invention, it is preferable to include the liposome cosmetic composition according to the present invention.

According to an embodiment of the present invention, it is preferable that the liposome cosmetic composition is contained in an amount of 0 to 70% by weight of the total weight of the oily base composition.

According to an embodiment of the present invention, it is preferable that the oily base composition is used as a base for a customized cosmetic composition.

Since the liposome cosmetic composition according to the present invention contains not only ceramide but also a large amount of oil, it increases moisturizing and softness, and prevents the release of ceramide and oil even when applied to a water-soluble cosmetic, and prevents coalescence between liposome particles, thereby improving the stability of cerosome. can be improved

In addition, the liposome cosmetic composition according to the present invention contains a large amount of oil, but it is easy to mix with an aqueous phase and has high stability, so it is suitable for use as an oily base when preparing a customized cosmetic according to a consumer's skin type.

1 shows the particle size analysis result of Example 1.
Figure 2 shows the Zeta Potential result of Example 1.
3 shows the results of particle size analysis of Comparative Example 2.
Figure 4 shows the Zeta Potential result of Comparative Example 2.

Hereinafter, the present invention will be described in more detail. However, this is only intended to describe the present invention in detail and does not limit the scope of the present invention.

The present invention is a ceramide; oil; a surfactant of Formula 1; organic solvents; anionic surfactants; and water; and a liposome cosmetic composition comprising

[Formula 1]

The surfactant of Formula 1 is a phospholipid containing a glycerin phosphate group.

The oil comprises 20% to 60% by weight of the total composition,

The anionic surfactant provides at least one liposome cosmetic composition selected from the group consisting of surfactants of Formula 2, Formula 3, and Formula 4

[Formula 2]

A is an alkyl chain, n is an integer from 12 to 18. B is a salt in which M is a group 1 metal.

[Formula 3]

A is an alkyl chain, and n is an integer from 12 to 18.

B is a salt wherein M is a group 1 metal.

[Formula 4]

A is an alkyl chain, and n is an integer from 12 to 18.

B is a salt wherein M is a group 1 metal.

In the compounds of Formulas 2 to 4, M is preferably sodium or potassium.

ceramide

Ceramides are naturally occurring sphingolipid compounds, and can be divided into three main groups: sphingosine (S), phytosphingosine (PS) or 6-hydroxysphingosine (HS) based on their properties. In this sphingosine base, it has chemically different properties due to the difference in the acyl chain attached to the long-chain non-hydroxy(N) or α-hydroxy(A) fatty acid through an amide bond. Ceramide is mainly produced from sphingomyelin (SM), a type of phospholipid constituting cell membrane, by hydrolysis of an enzyme called sphingomyelinase (SMase), and the stratum corneum, which occupies about 50% of the stratum corneum of the skin As a major polar lipid component of , it forms a lipid double membrane with moisture and has a moisture resistance and barrier function.

The surface of human skin is differentiated from the basal layer and matured keratinocytes are protected by degenerated corneocytes, and these keratinocytes are protected by the double-chain lamellar structure of ceramides present in large amounts in the stratum corneum. It binds to the skin and maintains its elasticity. That is, the ceramides are arranged side by side in a layered structure, and the layered structure exhibits the overall barrier function by being filled with moisture between them.

It is very important to maintain high levels of ceramides in the skin to maintain and promote healthy skin.

By replenishing ceramide from the outside, it is possible to restore the skin's lamellar structure and restore the skin to its normal state, and ceramide is known to have a moisturizing effect that not only supplies moisture to the skin but also prevents the moisture of the skin from escaping to the outside. , is known to help restore damaged skin barrier.

The ceramide may be any one or more of natural ceramides and similar ceramides.

The ceramide is preferably included in an amount of 1.0 to 5.0% by weight of the total weight of the liposome cosmetic composition.

The ceramide is composed of sphingosine and fatty acid and includes a compound represented by the following Chemical Formula 5, and one or more of the compounds represented by Chemical Formulas 6 to 14, which are various ceramides present in the stratum corneum of the skin, may be used, but is not limited thereto.

[Formula 5]

(Wherein, R is a straight-chain alkyl group having 12 to 47 carbon atoms, and may include a double bond and an ester bond.)

[Formula 6]

[Formula 7]

[Formula 8]

[Formula 9]

[Formula 10]

[Formula 11]

[Formula 12]

[Formula 13]

[Formula 14]

The ceramide that can be most preferably used in the present invention is Ceramide 3 [NP] represented by Formula 8, which is because Ceramide occupies the largest amount in the stratum corneum of the skin.

oil

The oils that can be used in the composition of the present invention include olive oil, grape seed oil, corn oil, macadamia oil, meadowfoam oil, which are triglyceride-based oils of vegetable origin, and synthetic esters and ethers, in particular esters and ethers of fatty acids and/or fatty alcohols. , for example, an oil of the _{formulas R 1} COOR ₂ and R ₁ OR _{2 (wherein R 1} CO represents a fatty acid residue, or R ₁ represents a fatty alcohol residue having 8 to 29 carbon atoms, and R ₂ is a C 3 to C 3 residue) 30 branched or unbranched hydrocarbon-based chain), for example 2-octyldodecyl stearate, 2-octyldodecyl erucate or isostearyl isostearate; Hydroxylated esters such as isostearyl lactate, octyl hydroxystearate, octyldodecyl hydroxystearate, diisostearyl maleate, triisocetyl citrate, and fatty alcohols heptanoate, octano 8 and decanoate; polyol esters such as propylene glycol dioctanoate, neopentyl glycol diheptanoate and diethylene glycol diisononanoate; and pentaerythritol esters such as pentaerythrityl tetraisostearate; and mixtures thereof;

one or more fatty acids containing at least 6 carbon atoms, preferably 6 to 26 carbon atoms, even more 6 to 20 carbon atoms, even more 6 to 16 carbon atoms, and 1 to 17 carbon atoms, more esters derived from the reaction of one or more alcohols further comprising 3 to 15 carbon atoms; In particular isopropyl myristate, isopropyl isostearate, isopropyl palmitate, 2-ethylhexyl caprate/caprylate (or octyl caprate/caprylate), 2-ethylhexyl palmitate, isostearyl neopenta noate, isononyl isononanoate, hexyl laurate, lactic acid esters of fatty alcohols having 12 or 13 carbon atoms, and dicaprylyl carbonate;

fatty alcohol ethers comprising 6 to 20 carbon atoms, preferably 8 to 12 carbon atoms, even more preferably 8 to 10 carbon atoms;

glycerol ethers having 6 to 12 carbon atoms, for example 2-ethylhexyl ether of glycerol (INCI name: ethylhexyl glycerol);

mixtures of esters of caprylic/capric acid and C ₁₂ -C ₁₈ fatty alcohols such as coco-caprylate/caprate;

esters of C ₈ -C ₃₀ fatty acids with Guerbet alcohols, in particular octyldodecanol and octyldodecanol esters such as octyldodecyl myristate; and mixtures thereof may be used.

Oils that can be preferably used in the present invention are, among them _{, esters of C 8} -C ₃₀ fatty acids and Guerbet alcohols, and esters and ethers of fatty acids and/or fatty alcohols, which increase the solubility of poorly soluble ceramide 3 [NP] to liposomes. This is because it not only facilitates manufacture, but also helps in stabilization that prevents the precipitation of ceramide in the liposome in the long term.

The oil is preferably included in 20 to 60% by weight of the total weight of the liposome cosmetic composition, more preferably 30 to 50% by weight, even more preferably 35% to 45% by weight.

This should be included in an amount of 20% by weight or more in order to be used as an oily base of a customized cosmetic composition in the future while increasing the moisturizing and suppleness, and if it is included in an excess of 60% by weight, the content of oil-soluble ingredients such as ceramide is reduced and skin functional reinforcement is about because it can be done.

Surfactant of Formula 1

In the present invention, the surfactant of Formula 1, that is, phospholipids containing glycerin phosphoric acid should be included.

[Formula 1]

Phospholipids containing glycerin phosphoric acid of Formula 1 are an essential component constituting a biological double membrane and have excellent biodegradability, non-irritation, and non-toxicity. It has a structure of a hydrophilic head group and a lipophilic two tail group, which is advantageous for forming liposomes. X of the phospholipid surfactant containing a glycerol phosphate group of Formula 1 includes Phosphatidylcholine, Phosphatidylethanolamine, Phosphatidylinositol, and Phosphatidylserine, and R ₁ , R ₂ is a C ₁₂ -C ₂₂ fatty acid.

The anions of the phospholipids repel each other with the anions of a specific anionic surfactant to generate a potential difference at the liposome interface, thereby preventing the release of ceramide and oil encapsulated in the liposome, and can prevent coalescence between liposome particles.

Preferred phospholipids include hydrogenated phospholipids in _{which R 1} and R ₂ are C ₁₆ to C _{18 fatty acids including glycerin phosphate.}

The surfactant of Formula 1 is preferably included in 2.0 wt% to 7.0 wt% of the liposome cosmetic composition.

organic solvent

The solvent may be any solvent in which phospholipids including glycerin phosphate, which is the main surfactant, can be dissolved, and examples thereof include 1,3-butylene glycol, propylene glycol, glycerin, dipropylene glycol and diglycerin. At least one solvent selected from may be used.

The solvent may be included in an amount of 20.00 wt% to 40.00 wt% of the liposome composition.

anionic surfactant

According to the present invention, the anionic surfactant selected from the group consisting of surfactants of Chemical Formulas 2 to 4 is preferably used.

[Formula 2]

A is an alkyl chain, n is an integer from 12 to 18. B is a salt in which M is a group 1 metal.

[Formula 3]

A is an alkyl chain, and n is an integer from 12 to 18.

B is a salt wherein M is a group 1 metal.

[Formula 4]

A is an alkyl chain, and n is an integer from 12 to 18.

B is a salt wherein M is a group 1 metal.

In the compounds of Formulas 2 to 4, M is preferably sodium or potassium.

This is because the potential difference is generated at the liposome interface due to the repulsive force between the anion of glycerin phosphate in the phospholipid and the anion of the anionic surfactant to prevent the precipitation of ceramide and oil in the liposome, and to prevent coalescence between the liposomes to improve stability. . In addition, in order to minimize skin irritation caused by the anionic surfactant used, it is preferable to use glutamate, sulfosuccinate, and sarcosinate groups, which are bulky structures with a rather large molecular weight, for the ester group of the B part of the anionic surfactant structure, and the C part alkyl chain is It is preferable to use 14 or more carbon atoms.

Preparation method of liposome cosmetic composition

The present invention also comprises the steps of heating to 70 ~ 90 ℃ while uniformly mixing the organic solvent, oil, ceramide, the surfactant of Formula 1, and the anionic surfactant of Formula 2, Formula 3 or Formula 4; separately heating water (purified water) to a heating temperature of the mixture; emulsifying for 5 to 10 minutes while mixing the organic component mixture and water; It provides a method for producing a cerosome cosmetic composition comprising; passing the emulsified composition in a high-pressure emulsifier in a pressure of 1000 to 2000 bar twice in succession to prepare liposomes.

According to one embodiment of the present invention, there is provided an oily base composition comprising the serasome according to the present invention.

The oily base composition means that it can be used as a base composition for cosmetics, which must contain a large amount of oil when preparing the cosmetic composition.

Therefore, it can be used as a base composition for various cosmetic compositions, such as basic cosmetics and essence compositions, which must contain an excess of oil depending on the skin type.

It is preferable that the cerosome composition of the present invention be used as an oily base in the preparation of a customized cosmetic composition, which is delicately adjusted to suit the skin type of the user. This is because the cerosome composition of the present invention contains 20% by weight or more of ceramide and oil, preferably 50% by weight or more of oil, unlike the existing oily base composition, and when used as a base for a customized cosmetic composition, This is because even if it is mixed and contained in less than 20% by weight of the total customized cosmetic composition, the oil is sufficiently contained in the serasome itself, so that a sufficient oily feeling can be maintained. In addition, it is easy to mix with an aqueous base, and its stability is excellent, so that even when stored for a long time for use as a base for customized cosmetics, ceramide or oil does not leak and remains in the form of cerosomes. easy to

According to the present invention, a cosmetic composition for moisturizing the skin is provided using the oily base composition according to the present invention. In addition, the cosmetic composition using the oily base composition according to the present invention may be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, etc., and more specifically, a softening lotion, a nourishing cream, a massage cream, and an essence. , can be prepared in the form of eye cream, etc.

The cosmetic composition is not limited thereto, but may be a cosmetic composition of a transparent solubilizing formulation comprising 1 to 10% by weight of a moisturizer and 0.1 to 0.5% by weight of a thickener.

The thickener is not limited thereto, but an acrylate/C-10-30 alkyl acrylate crosspolymer is preferred.

The moisturizing agent is not limited thereto, but polyols, sugars, amino acids, and fermentation extracts may be preferable, and the polyol is not limited thereto, but butylene glycol, dipropylene glycol, propylene glycol, dipropylene glycol It may be one selected from chol, pentylene glycol, caprylyl glycol, glycerin, diglycerin, ethylhexyl glycerin, polyglycerin, 1,2-hexanediol, and 1,2-octanediol. The saccharide is not limited thereto, but may be one selected from beta-glucan, biosaccharide gum, and sorbitol. The fermentation extract is not limited thereto, but may be one selected from algae extract, Lactobacillus / fermented algae extract, yeast / fermented hair root extract, yeast / mistletoe fermented extract, and Lactobacillus / fermented soybean extract.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and it is to those of ordinary skill in the art to which the present invention pertains that the scope of the present invention is not limited by these examples according to the gist of the present invention. it will be self-evident

<Examples and Comparative Examples> Preparation of liposome composition

It was prepared according to the configuration of Table 1 below. The organic solvent, the surfactant of Formula 1, ceramide, oil, and the anionic surfactant of Formula 2, Formula 3 or Formula 4 were uniformly mixed using a disperser (Homogenizing Disper, Model 2.5, Primix) and heated to 80°C. And the purified water was heated to 80 ℃. The emulsification process was carried out at 80° C. for 5 minutes using a homogenizing mixer (Homogenizing Mixer, Mark II, Model 2.5, Primix). The first emulsified composition was passed through a high pressure emulsifier at 1,000 bar twice in succession to prepare a liposome composition containing ceramide and oil.

(Unit: % by weight) Example comparative example One 2 3 One 2 3 4 organic solvent glycerin 30 30 30 30 30 30 30 oil Octyldodecanol 40 40 55 40 15 40 40 Surfactants Surfactant belonging to Formula 1 5 5 5 5 5 5 - As a surfactant that does not belong to Formula 1
Polyglyceryl-3-methylglucose distearate - - - - - - 5 ceramide Ceramide NP 5 - 5 5 5 5 - Pseudoceramide of Formula 8 - 5 - - - - - negative ions
Surfactants Sodium Stearoyl Glutamate 2 2 2 - - - 2
Polysorbate 60
- - - - - 2 - Purified water To 100 Sum `100

<Experimental Example 1> Comparison of experimental results of Examples and Comparative Examples

The weight ratio of each composition is shown in Table 1 above, and the types of anionic surfactants, types of ceramides, contents of anionic surfactants, contents of oil, etc. were prepared differently and compared.

In a separate container, the organic solvent, oil, ceramide, surfactant of Formula 1 or surfactant not belonging to Formula 1, and anionic surfactant not belonging to Formula 2, 3, and 4 were uniformly mixed and heated to 70-90°C. In a separate container, water (purified water) was heated to the heating temperature of the mixture. After emulsifying the mixture for 5 to 10 minutes while mixing the mixture and water, the emulsified composition was passed through a high pressure emulsifier twice in succession under a pressure of 1000 to 2000 bar to prepare liposomes. Hydrogenated lecithin was used as the surfactant of Formula 1 used in this experiment, and polyglyceryl-3methylglucose distearate was used as the surfactant not belonging to Formula 1. In addition, sodium stearoyl glutamate was used as the anionic surfactant according to the present invention, and polysorbate 60 was used as the surfactant not belonging to Chemical Formulas 2 to 4.

In the case of Example 1, apparently stable liposomes were prepared, and the average particle size was 115.7 nm (St Deviation 55.08, Zetasizer, Marven) and the zeta potential value was -68.6 mV (St Deviation 13.4 mV, Zetasizer, Marven). (Fig. 1, Fig. 2)

In the case of Comparative Example 1, it was impossible to prepare liposomes because phase inversion occurred during the primary emulsion preparation process at 80°C.

In Comparative Example 2, apparently stable liposomes were prepared, and the average particle size was 206.5 nm (St Deviation 130.4, Zetasizer, Marven) and the zeta potential value was -60.5 mV (St Deviation 13.4 mV, Zetasizer, Marven). (FIGS. 3 and 4)

Based on the results of Example 1 and Comparative Examples 1 and 2, when preparing liposomes containing a large amount of ceramide and oil, using a specific anionic surfactant prevents phase inversion to W/O generated during the manufacturing process, and oil In spite of the 3-fold increase in the content of , the average particle size formed is reduced by about half, and the zeta potential value is increased, indicating that the stability of the serasome is improved when an anionic surfactant is used. In general, the stability evaluation standard estimated by the zeta potential value is -60.5mV as 'normal-stable', and -68.6mV as 'very stable'.

In the case of Comparative Example 3, a relatively large stable liposome having an average particle size of 280 nm (St Deviation 145.8, Zetasizer, Marven) was prepared. However, as a result of the stability evaluation for each temperature below, a problem was found in that oil was precipitated at high temperatures (43°C, 50°C) during one-month evaluation.

For Comparative Example 4, stable liposomes having an average particle size of 130.8 nm (St Deviation 85.10, Zetasizer, Marven) were prepared. However, as a result of the stability evaluation for each temperature below, a problem was found in that the emulsified particles were united at a high temperature (43° C., 50° C.) during one month evaluation and the phases were separated.

Comparing Comparative Examples 3 and 4 with Example 1, desirable results can be obtained only when a specific anionic surfactant and the surfactant of Formula 1 are used, and when one surfactant is used as the other, stability is very low. it can be seen that

<Experimental Example 2> Temperature stability evaluation results of Examples and Comparative Examples

The stability evaluation results of cosmetic standards, Examples and Comparative Examples are shown in Table 2 below. The results of stability or instability in the evaluation chamber (chamber) for each temperature are shown. As for stability by temperature, FT (Freezing-Thaw, thaw after freezing) is repeated 3 times, refrigerated (0℃~4℃) 3 months, 25℃ 6 months, 43℃ 3 months, 50℃ 1 month, low temperature cycle (5 ℃~10℃, repeat once/day) 6 months, high temperature cycle (-10℃~45℃, repeat once/day) 3 months follow the standards of In the case of Example 1 and Comparative Example 2, the stability evaluation result of the liposome composition was good.

<Experimental Example 3> Preparation and stability evaluation results of aqueous formulations applied to Examples and Comparative Examples

In order to evaluate the stability of Examples 1 to 3 and Comparative Examples 2 to 4 in the aqueous formulation, the composition of Examples 1 to 3 and Comparative Examples 2 to 4 was used to prepare an aqueous formulation (skin) as shown in Table 3. Purified water, trisodium EDTA, 1,2-hexanediol, ammonium acryloyldimethyltaurate/V-copolymer were mixed well at room temperature for at least 20 minutes using an Agi-mixer, 1, 2, and 3 and Comparative Examples 2, 3, and 4 were respectively added and mixed using an agi-mixer for at least 10 minutes with low shear force to prepare Example skins and Comparative Example skins.

ingredient content (wt%) Purified water to 100 Trisodium EDTA 0.01 1,2-hexanediol (1,2-hexanediol) 2.00 Ammonium Acryloyldimethyltaurate/VP Copolymer 0.20 Composition of Example 1 20.00 Composition of Example 2 Composition of Example 3 Composition of Comparative Example 2 Composition of Comparative Example 3 Composition of Comparative Example 4 Sum 100.00

The stability evaluation results of the skins of Examples and Comparative Examples are shown in Table 4 below. The results show the stability evaluation results in the chamber for each temperature. The stability evaluation criteria for each temperature are the same as those mentioned in Experimental Example 3. Comparative Example 2 In the case of the skin, an unstable evaluation result is shown when about 2 weeks pass at a high temperature. As a specific phenomenon of instability, it refers to a case where there is a phenomenon such as precipitation of ceramide, oil precipitation, etc.

Temperature skin stability Example comparative example One 2 3 2 3 4 frozen stability stability stability stability stability stability cold storage stability stability stability stability stability stability 25℃ stability stability stability stability stability stability 43℃ stability stability stability Instability Instability Instability 50℃ stability stability stability Instability Instability Instability low temperature cycle stability stability stability stability stability stability high temperature cycle stability stability stability Instability Instability Instability

<Experimental Example 4> Consumer panel moisturizing power and emotional quality evaluation result of Example skin and Comparative Example skin

In the case of the skins of Examples 1 to 3, it was judged that the softness and moisturizing feeling were excellent due to the high oil content due to the high oil content compared to the comparative example 2 skin. . (Date: March 2019) Moisture power was evaluated using a Janus III (PIE) moisture meter, and emotional quality was evaluated using a questionnaire, and the evaluation scale was 1 point (very dissatisfied) and 2 points out of 5 points. (Dissatisfied), 3 points (average), 4 points (satisfactory), and 5 points (very satisfied) were assigned.

As a result of the moisturizing power evaluation in Table 6, it can be seen that in the case of the skins of Examples 1 to 3, the skin moisture power was increased before and after 8 hours of application compared to the skin of Comparative Example 2.

For emotional quality evaluation, three items were evaluated: skin moisture, softness, and skin texture after use. In the case of the skin of Example 1, as shown in Table 7, superior emotional quality evaluation was possible in all items.

age number of panelists by skin type number of panelists 20's 18 people inattention 46 people 30's 18 people complexity 31 people 40's 63 people neutrality 17 people 50's 14 people Intelligence 19 people 113 people 113 people

skin Example comparative example One 2 3 2 just before application 35 34 36 35 immediately after application 60 61 72 42 2 hours after application 52 53 70 38 4 hours after application 50 53 70 37 6 hours after application 51 50 68 35 8 hours after application 48 47 66 32

skin Example comparative example One 2 3 2 moisturizing 4.6 4.5 4.7 3.5 Soft 4.2 4.1 4.5 4.0 skin texture 4.5 4.3 4.7 3.2

Claims (11)

ceramide; oil; a surfactant of Formula 1; organic solvents; anionic surfactants; and water; and a liposome cosmetic composition comprising
[Formula 1]

The surfactant of Formula 1 is a phospholipid containing a glycerin phosphate group,
The oil comprises 20% to 60% by weight of the total composition,
The anionic surfactant is at least one selected from the group consisting of surfactants of Formula 2, Formula 3, and Formula 4, in a liposome cosmetic composition.
[Formula 2]

(A is an alkyl chain, n is an integer of 12 to 18. B is a salt in which M is a group 1 metal.)
[Formula 3]

(A is an alkyl chain, n is an integer from 12 to 18. B is a salt in which M is a group 1 metal.)
[Formula 4]

(A is an alkyl chain, n is an integer from 12 to 18. B is a salt in which M is a group 1 metal.) According to claim 1,
The liposome cosmetic composition, characterized in that the oil is included in 30% to 50% by weight of the total weight of the liposome cosmetic composition. According to claim 1,
wherein said oil is a natural oil selected from the group consisting of olive oil, grape seed oil, corn oil, macadamia oil and meadowfoam oil; synthetic esters, synthetic ethers, esters of fatty acids or fatty alcohols, ethers of fatty acids or fatty alcohols, or esters derived from the reaction of one or more alcohols containing 12 to 20 carbon atoms; And fatty alcohol ether containing 12 to 20 carbon atoms; Liposome cosmetic composition, characterized in that at least one selected from the group consisting of. According to claim 1,
The ceramide is ceramide EOP (Ceramide EOP), ceramide NS (Ceramide NS), ceramide NP (Ceramide NP), ceramide AS (Ceramide AS) and ceramide AP (Ceramide AP) liposome, characterized in that at least one selected from the group consisting of cosmetic composition. According to claim 1,
The liposome cosmetic composition, characterized in that the organic solvent is a mixture of at least one selected from the group consisting of 1,3-butylene glycol, propylene glycol, glycerin, dipropylene glycol and diglycerin. According to claim 1,
Liposome cosmetic composition, characterized in that the surfactant of Formula 1 is selected from the group consisting of phospholipids containing glycerin phosphoric acid. According to claim 1,
The liposome cosmetic composition, characterized in that the anionic surfactant is 0.01 to 5% by weight of the total weight of the liposome cosmetic composition. An oily base composition comprising the liposome cosmetic composition according to any one of claims 1 to 7. 9. The method of claim 8,
Oily base composition, characterized in that it further comprises a polymer. 9. The method of claim 8,
The oily base composition, characterized in that the liposome cosmetic composition is contained in an amount of 0 to 70% by weight of the total weight of the oily base composition. 9. The method of claim 8,
The oily base composition is an oily base composition, characterized in that it is used as a base for a customized cosmetic composition.

Images