KR20190050697A - Method for the Preparation of Cosmetic Composition Comprising Mixed Ceramides and Cosmetic Composition Prepared by the Same - Google Patents

Abstract

The present invention provides a cosmetic composition comprising purified water, ceramide as an insoluble substance, and a surfactant that increases the solubility of the ceramide in the purified water, wherein the ceramide may be a mixed ceramide of two or more ceramides selected from the group comprising ceramide 1 (ceramide EOP), ceramide 2 (ceramide NS), ceramide 3 (ceramide NP), ceramide 5 (ceramide AS), and ceramide 6 (ceramide AP). The cosmetic composition comprising the mixed ceramide of the present invention has a remarkably excellent feeling in use and moisturizing power.

Description

[0001] The present invention relates to a method for producing a cosmetic composition containing a mixed ceramide, and a cosmetic composition prepared by the method.

The present invention relates to a method for producing a cosmetic composition comprising a mixed ceramide, and a cosmetic composition prepared by the method. More particularly, the present invention relates to a cosmetic composition comprising Ceramide EOP, Ceramide NS, Ceramide NP, The present invention relates to a method for preparing a cosmetic comprising a plurality of ceramides selected from the group comprising Ceramide AS and Ceramide AP and a cosmetic composition prepared by the method.

Ceramide is a naturally occurring sphingolipid compound, specifically N-palmityl sphingosine represented by the following formula (1). Ceramides are characterized by the presence of an amino group in the fatty acid radical.

[Chemical Formula 1]

Ceramide is produced mainly by the hydrolysis of sphingomyelinase (SMase) from sphingomyelin (SM), a kind of cell membrane phospholipid, Is a major polar lipid component that forms a lipid bilayer membrane together with moisture to provide moisture and barrier functions.

The surface of human skin is differentiated from the basal layer and protected by keratinocytes, which are degraded keratinocytes. These keratinocytes are formed by the double-chain lamellar structure of ceramides existing in the stratum corneum, So that the elasticity of the skin can be maintained. That is, the ceramides are arranged side by side in a layered structure, and water is filled and held therebetween, so that the layered structure exerts the overall barrier function.

However, as age ages, as the skin ages, the amount of ceramide in the stratum corneum decreases, which reduces the ability of the keratinocytes to bind to the skin surface, thus rendering the skin unprotected. That is, as the content of ceramides in the stratum corneum decreases, exposure to external stimuli such as loss of moisture, ultraviolet rays or chemicals, and exfoliation of the keratinocyte occur and the surface of the skin becomes rough.

In addition, the relationship between the health of the skin and the sphingolipid is very close in the light of the fact that abnormal ceramide levels (sphingolipids deficiency) are commonly observed in atopic eczema, dermatitis and psoriasis.

In light of the foregoing, it is very important to maintain a high level of ceramide in the skin in order to maintain and promote healthy skin.

Research has shown that ceramides can be restored to normal state by restoring the lamellar structure of the skin by supplementing ceramides from the outside in the academia, and ceramides not only supply moisture to the skin, It is known that it has a moisturizing effect that prevents the skin barrier from being damaged. As it is known that this helps the recovery of damaged skin barrier, ceramide is widely used as a main ingredient of functional cosmetics, skin and hair moisturizer.

However, ceramide is a poorly soluble substance and is dissolved only in an oil-soluble substance at a high temperature of 120 or more, making it difficult to use it as a cosmetic composition. Particularly, since the solubility of the purified water, which is the most basic raw material of cosmetic materials, is greatly reduced, it is not used at all in the cosmetics for cosmetics and cosmetics, and it is known that cosmetic ingredients can not be prepared only by the oil component .

Conventionally, a method of liposomizing natural lecithin using a high-pressure hydraulic device (microfluidizer) has been devised in order to solve the difficulty of such ceramides. However, since ceramide is encapsulated in a very fine liposome formed of a lecithin film, And only about 0.1-3.0 wt.% Of the cosmetic composition is contained in the cosmetic composition, and it is impossible to contain a large amount of ceramide.

In addition, there is a method of producing a cosmetic composition containing a large amount of ceramide by using a solvent having a high polarity or emulsifying it through a surfactant. However, a highly polar solvent such as C12-14 alkylbenzoate or octyldodecanol has a feeling of use And thus there is a problem in that there is a risk of skin irritation when a surfactant is used.

In order to solve the above-mentioned problems, in KR Patent Application No. 10-2012-0089886 (entitled "Untreated Sphing Pitch Feed"), 100 parts by weight of a sphingolipid as an insoluble substance and 100 parts by weight of an alkyl Wherein the amount of the surfactant is in the range of 10-200 parts by weight based on the sphingolipids, and the surfactant has a shape in which the outer periphery of the sphingolipids is amorphously surrounded and adhered Characterized in that an average diameter of the sphingolipids attached to the surfactant is 0.5-30 mu m and an average range of the size is within ± 200% of the diameter of the mixed ceramide. Lt; / RTI >

However, in the case of the cosmetic composition contained in the above-mentioned patent documents, the problem of water dispersion of ceramides could be almost completely solved, but there still remains a part to be improved in terms of specific use feeling of the cosmetic composition.

Numerous papers and patent documents are referenced and cited throughout this specification. The disclosures of the cited papers and patent documents are incorporated herein by reference in their entirety to better understand the state of the art to which the present invention pertains and the content of the present invention.

The inventors of the present invention have made extensive efforts to improve the feeling of use by maximizing the moisturizing power of the existing ceramide cosmetic composition. As a result, the present inventors have found that the use of five kinds of ceramides can be remarkably improved as compared with a cosmetic composition containing only a single kind of ceramide.

Accordingly, an object of the present invention is to provide a cosmetic composition containing a mixed ceramide.

Another object of the present invention is to provide a method for producing a cosmetic composition containing mixed ceramides.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

The present invention provides a cosmetic composition.

The inventors of the present invention have made extensive efforts to improve the feeling of use by maximizing the moisturizing power of the existing ceramide cosmetic composition. As a result, it was confirmed that when five types of ceramides were mixed at an appropriate ratio, the use feeling could be remarkably improved as compared with a cosmetic composition containing only a single type of ceramide.

According to one aspect of the present invention, the present invention provides a method for producing ceramides, which comprises purifying water, a ceramide as a poorly soluble substance, and a surfactant for increasing the solubility of the ceramide to the purified water, A cosmetic composition comprising a mixed ceramide mixed with at least two ceramides selected from the group consisting of Ceramide NS, Ceramide NP, Ceramide AS and Ceramide AP. Lt; / RTI >

The term " poorly soluble " as used herein may mean that the pharmacologically active agent is not dissolved in an aqueous solution (e.g. water, physiological saline, injectable dextrose solution, etc.). USP / NF generally expresses solubility as the volume of solvent needed to dissolve 1 gram of drug at a specific temperature (eg, 1 g of aspirin in 300 ml of H2O, 25 ml of 5 ml of ethanol).

The term 'hydrophilic, water soluble, soluble or soluble' as used herein refers to conventional dissolution, emulsification, liposomal form, and KR Patent Application No. 10-2012-0027176 (entitled " ), KR Patent Application No. 10-2012-0027177 (entitled "Abrasive Interphase Material Containing a Fatty Acid Having a Linear Alkyl Chain"), KR Patent Application No. 10-2012-0027174 And non-woven interfacial material states used in KR Patent Application No. 10-2012-0027175 (entitled "Anhydrous Permanent Interfacial Substance").

According to a preferred embodiment of the present invention, the mixed ceramides of the present invention are preferably a mixture of ceramide 2 and ceramide 3, a mixture of ceramide 2 and ceramide 5, a mixture of ceramide 2 and ceramide 6, a mixture of ceramide 3 and ceramide 5, A mixture of ceramide 3 and ceramide 6, and a mixture of ceramide 5 and ceramide 6.

In the present invention, it is very important to be able to select various kinds of ceramide mixtures. For this reason, it has been found that when a mixture of two kinds of ceramides is used in combination as a result of a number of experiments, the feel and moisturizing power of the cosmetic composition can be remarkably improved.

According to a preferred embodiment of the present invention, the mixture of the present invention may preferably be a mixture of the respective ceramides in a ratio of 1: 4 to 4: 1 by weight.

In the present invention, the above-mentioned combination of ceramides is included in the above-mentioned ratio in a very important configuration. This is because, as a result of many experiments, it has been found that when two kinds of ceramides are mixed and used in the above-mentioned ratio, feeling and moisturizing power of the cosmetic composition can be remarkably improved.

In the present invention, the mixed ceramide may be made water-soluble by the hydrophilic part of the surfactant or the emulsifier in a state where the outer periphery is amorphously bound and adhered by a surfactant or an emulsifier.

According to a preferred embodiment of the present invention, the surfactant or emulsifier may be selected from a variety of surfactants or emulsifiers used in the art, but preferably a surfactant or emulsifier having two or more alkyl chains can be used, Lecithin or hydrogenated lecithin may be used as the phospholipid, and lecithin may be most preferably used.

According to a preferred embodiment of the present invention, the surfactant may be a natural surfactant or a synthetic surfactant.

Natural surfactants include at least one interface selected from the group comprising soy lecithin, egg lecithin, hydrogenated lecithin (hydrogenated soy lecithin and hydrogenated egg lecithin), sphingosine, ganglioside and phytosphingosine But are not limited thereto.

Natural lecithin is a mixture of diglycerides of stearic acid, palmitic acid and oleic acid linked to a choline ester of phosphoric acid, commonly referred to as phosphatidylcholine, and can be obtained from a variety of sources such as eggs and soybeans. Soybean lecithin and egg lecithin (including hydrogenated lecithin) have long been safe in biological systems, have both emulsifying and solubilizing properties, and tend to degrade faster than most synthetic surfactants in a more harmless way. Commercially available soybean lecithins include Centrophase and Centrolex products [Central Soya], Phospholipon [Phospholipid GmbH, Germany], Lipoid [Lipoid GmbH, Germany] and EPIKURON [Degussa].

Hydrogenated lecithin is the product of controlled hydrogenation of lecithin and may be included in the technical idea of the present invention.

According to the USP, lecithin is composed of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphotidylinositol, mixed with various substances such as triglycerides, fatty acids and carbohydrates in various amounts. Acetone-insoluble phospholipids.

Pharmaceutically, lecithin is primarily used as a dispersant, emulsifier and stabilizer, and is included in intramuscular and intravenous injections, parenteral nutritional formulations and topical products. Lecithin is also listed in the FDA Inactive Ingredients Guide for inhalants, IM and IV injections, oral capsules, suspensions and tablets, rectal preparations, topical preparations and vaginal preparations.

According to a preferred embodiment of the present invention, the content of the surfactant or emulsifier may be 10-200 parts by weight, more preferably 20-80 parts by weight, based on 100 parts by weight of the mixed ceramides , And most preferably 40-60 parts by weight. In the case of conventional liposomes, 5-10% of surfactant is used to dissolve 1.0% of ceramide. In the case of mixed ceramides according to the present invention, however, even if only 0.2-1.0% of surfactant is used to dissolve 1% ceramide, It is easy to dissolve in water.

According to a preferred embodiment of the present invention, the size of the mixed ceramides is preferably 0.5-30 mu m, more preferably 1-10 mu m, and most preferably 1.5-5 mu m.

The size of the mixed ceramides of the present invention is very important in terms of the function of melting a poorly soluble substance. Because the hydrophobic group of the surfactant is an important factor in determining the amount of poorly soluble material that can be present.

According to a preferred embodiment of the present invention, the average range of the mixed ceramide size of the present invention is preferably -200% to 200%, more preferably -30% to 30%, and most preferably- 10% to 10%. High homogeneity is a very important component that significantly delays recrystallization of the mixed ceramides.

As described above, in order to significantly increase the homogeneity of the mixed ceramides of the present invention, an inline mixer including a mixed blade structure having the concept of blending and mixing should be used.

According to a preferred embodiment of the present invention, the mixed ceramides may further include a fatty acid present between the surfactant and the mixed ceramide.

According to a preferred embodiment of the present invention, the fatty acid is preferably selected from the group including, but not limited to, stearic acid, palmitic acid, myristic acid and lauric acid.

According to a preferred embodiment of the present invention, the fatty acid may include 1-1000 parts by weight, more preferably 10-500 parts by weight, and most preferably 20-100 parts by weight, relative to the mixed ceramides can do.

According to another aspect of the present invention, the present invention provides a method for preparing a cosmetic composition comprising a mixed ceramide comprising the steps of:

(a) mixing a surfactant having two or more alkyl chains attached to a hydrophilic moiety and a polar organic solvent having two or more OH groups;

(b) raising the temperature of the mixture of step (a) to raise the fluidity of the mixture;

(c) Ceramides as a poorly soluble substance in the mixture of step (b) are selected from a mixture of ceramide 2 and ceramide 3, a mixture of ceramide 2 and ceramide 5, a mixture of ceramide 2 and ceramide 6, a mixture of ceramide 3 and ceramide 5, 3 and a mixture of ceramides 6 and a mixture of ceramides 5 and ceramides 6;

(d) mixing and mixing the mixed ceramic mixture of step (c) with a mixer including a mixed blade structure having a concept of mixing the mixture; And

(e) solidifying the re-mixed mixture of step (d).

According to a preferred embodiment of the present invention, the mixed ceramides of the present invention may preferably be a mixture of the respective ceramides in a ratio of 1: 4 to 4: 1 by weight.

The features and advantages of the present invention are summarized as follows:

(a) Ceramide as a refined water, a poorly soluble substance, and a surfactant for increasing the solubility of the ceramide in the purified water, wherein the ceramide is selected from the group consisting of Ceramide EOP, Ceramide 2 The present invention provides a cosmetic composition comprising a mixed ceramide mixed with at least two ceramides selected from the group consisting of Ceramide NS, Ceramide NP, Ceramide AS and Ceramide AP.

(b) The cosmetic composition containing the mixed ceramide of the present invention has a remarkably excellent feeling of use and moisturizing power.

Fig. 1 shows the measurement results of in-vitro water loss in Examples 1 to 9.
Fig. 2 shows the in-vitro moisture loss measurement results of Examples 10 to 18. Fig.
Fig. 3 shows the measurement results of in-vitro moisture loss of Examples 19 to 27. Fig.
Fig. 4 shows results of in-vitro water loss measurements of Examples 28 to 36. Fig.
Fig. 5 shows the measurement results of in-vitro moisture loss of Examples 37 to 45. Fig.
Fig. 6 shows results of in-vitro water loss measurements of Examples 46 to 54. Fig.
Fig. 7 shows the in-vitro water loss measurement results of the control, control and untreated control.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not to be construed as limiting the scope of the present invention. It will be self-evident.

Example

Throughout this specification, "%" used to denote the concentration of a particular substance is intended to include solids / solids (wt / wt), solid / liquid (wt / The liquid / liquid is (vol / vol)%.

Manufacturing example

Manufacturing example  1: Preparation of mixed ceramide

The relatively stable ceramides and dipropylene glycol were dispersed at high temperature in the first open tank with the compositions of Tables 1 to 7 below, and premixed with hydrogenated lecithin (PC 75%) and hydrogenated lecithin at high temperature in the second open tank Glyceryl stearate and stearic acid were mixed with stirring, and then the solutions of the first open tank and the second open tank were stirred and mixed by an inline mixer to prepare the mixed ceramides of Examples 1 to 54 and Comparative Examples 1 to 4 Respectively.

Example ( weight% ) One 2 3 4 5 6 7 8 9 Comparative Example 1 Ceramide 2 36 32 28 24 20 16 12 8 4 40 Ceramide 3 4 8 12 16 20 24 28 32 36 - Ceramide 5 - - - - - - - - - - Ceramide 6 - - - - - - - - - - Hydrogenated lecithin 20 20 20 20 20 20 20 20 20 20 Stearic acid 10 10 10 10 10 10 10 10 10 10 Dipropylene glycol 20 20 20 20 20 20 20 20 20 20 Glyceryl stearate 10 10 10 10 10 10 10 10 10 10

Example ( weight% ) 10 11 12 13 14 15 16 17 18 Comparative Example 2 Ceramide 2 36 32 28 24 20 16 12 8 4 - Ceramide 3 - - - - - - - - - 40 Ceramide 5 4 8 12 16 20 24 28 32 36 - Ceramide 6 - - - - - - - - - - Hydrogenated lecithin 20 20 20 20 20 20 20 20 20 20 Stearic acid 10 10 10 10 10 10 10 10 10 10 Dipropylene glycol 20 20 20 20 20 20 20 20 20 20 Glyceryl stearate 10 10 10 10 10 10 10 10 10 10

Example ( weight% ) 19 20 21 22 23 24 25 26 27 Comparative Example 3 Ceramide 2 36 32 28 24 20 16 12 8 4 - Ceramide 3 - - - - - - - - - - Ceramide 5 - - - - - - - - - 40 Ceramide 6 4 8 12 16 20 24 28 32 36 - Hydrogenated lecithin 20 20 20 20 20 20 20 20 20 20 Stearic acid 10 10 10 10 10 10 10 10 10 10 Dipropylene glycol 20 20 20 20 20 20 20 20 20 20 Glyceryl stearate 10 10 10 10 10 10 10 10 10 10

Example ( weight% ) 28 29 30 31 32 33 34 35 36 Comparative Example 4 Ceramide 2 - - - - - - - - - - Ceramide 3 36 32 28 24 20 16 12 8 4 - Ceramide 5 4 8 12 16 20 24 28 32 36 - Ceramide 6 - - - - - - - - - 40 Hydrogenated lecithin 20 20 20 20 20 20 20 20 20 20 Stearic acid 10 10 10 10 10 10 10 10 10 10 Dipropylene glycol 20 20 20 20 20 20 20 20 20 20 Glyceryl stearate 10 10 10 10 10 10 10 10 10 10

Example ( weight% ) 37 38 39 40 41 42 43 44 45 Ceramide 2 - - - - - - - - - Ceramide 3 36 32 28 24 20 16 12 8 4 Ceramide 5 - - - - - - - - - Ceramide 6 4 8 12 16 20 24 28 32 36 Hydrogenated lecithin 20 20 20 20 20 20 20 20 20 Stearic acid 10 10 10 10 10 10 10 10 10 Dipropylene glycol 20 20 20 20 20 20 20 20 20 Glyceryl stearate 10 10 10 10 10 10 10 10 10

Example ( weight% ) 46 47 48 49 50 51 52 53 54 Ceramide 2 - - - - - - - - - Ceramide 3 - - - - - - - - - Ceramide 5 36 32 28 24 20 16 12 8 4 Ceramide 6 4 8 12 16 20 24 28 32 36 Hydrogenated lecithin 20 20 20 20 20 20 20 20 20 Stearic acid 10 10 10 10 10 10 10 10 10 Dipropylene glycol 20 20 20 20 20 20 20 20 20 Glyceryl stearate 10 10 10 10 10 10 10 10 10

Manufacturing example  2: Containing mixed ceramide Milk lotion  Produce

Examples 1 to 54 and Comparative Examples 1 to 4 Formulations of milk lotion among cosmetic compositions containing mixed ceramides are shown in Table 7 below.

ingredient Example
( weight% ) Comparative Example
( weight% ) Example  Mixed ceramide 0.6 - Comparative Example  Mixed ceramide - 0.6 glycerin 5.1 5.1 Propylene glycol 4.2 4.2 Tocopheryl acetate 3.0 3.0 Liquid paraffin 4.6 4.6 Triethanolamine 1.0 1.0 Squalane 3.1 3.1 Macadamia nut oil 2.5 2.5 Polysorbate  60 1.6 1.6 Sorbitan sesquiterate 1.6 1.6 Propylparaben 0.6 0.6 Carboxyl vinyl polymer 1.5 1.5 incense a very small amount a very small amount antiseptic a very small amount a very small amount Purified water Balance Balance system 100 100

Experimental Example

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Experimental Example  1: Measurement of in-vitro water loss

6 mL of water was added to a 10 mL vial bottle, and a membrane filter (FMIXED CELLULOSE ESTER A020A047A / ADVANTEC) was attached to the lid having a hole (diameter: 8 mm). Examples 1 to 54 and Comparative Examples 1 to 4 The mixed ceramides were diluted 6-fold to prepare emulsified samples, and 0.03 g of the sample in the emulsion state was dropped on the membrane filter. As the control, an emulsion having the same viscosity as that of the sample in the emulsion state but not containing ceramide was used. After standing for 1 hour, the weight was measured and set to the initial weight. The container was kept in a thermostat at 45 ° C for 3 days, and the weight loss was measured by measuring the weight after 3 days. The results are shown in Table 8 and FIGS. 1 to 6.

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 moisture
Loss amount 0.47 g 0.39 g 0.38 g 0.37 g 0.35 g 0.36 g 0.36 g 0.38 g 0.43 g Example 10 Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 Example 17 Example 18 moisture
Loss amount 0.39 g 0.30 g 0.31 g 0.32 g 0.27 g 0.29 g 0.29 g 0.31 g 0.40 g Example 19 Example 20 Example 21 Example 22 Example 23 Example 24 Example 25 Example 26 Example 27 moisture
Loss amount 0.44 g 0.39 g 0.38 g 0.34 g 0.32 g 0.35 g 0.36 g 0.37 g 0.45 g Example 28 Example 29 Example 30 Example 31 Example 32 Example 33 Example 34 Example 35 Example 36 moisture
Loss amount 0.33 g 0.32 g 0.29 g 0.26 g 0.22 g 0.25 g 0.26 g 0.30 g 0.31 g Example 37 Example 38 Example 39 Example 40 Example 41 Example 42 Example 43 Example 44 Example 45 moisture
Loss amount 0.31 g 0.27 g 0.25 g 0.23 g 0.21 g 0.22 g 0.25 g 0.27 g 0.30 g Example 46 Example 47 Example 48 Example 49 Example 50 Example 51 Example 52 Example 53 Example 54 moisture
Loss amount 0.35 g 0.32 g 0.30 g 0.30 g 0.29 g 0.31 g 0.31 g 0.33 g 0.34 g Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Control Non-treatment moisture
Loss amount 0.48 g 0.37 g 0.38 g 0.40 g 0.88 g 0.97 g

Experimental Example  2 : Cosmetics  Of the composition Feeling  evaluation

In order to confirm the effect of the feeling of use and the duration of the cosmetic composition which gives the feeling of use improvement and duration time increasing effect to the cosmetic according to the present invention, the human body experiment was carried out as follows.

1. Subject and Period

In this experiment, 20 women aged 20 to 40 years were included in the study. The duration of the experiment was 300 days.

2. Experimental Method

20 cosmetics compositions prepared by the method of Preparation Example 2 containing the ceramide complexes of Examples 1 to 54 and Comparative Examples 1 to 4 (hereinafter referred to as' Examples 1 to 54 (Hereinafter referred to as " cosmetic composition of Comparative Examples 1 to 4 "), respectively, and scores were given to the feeling of use. 10 ml of each of the cosmetic compositions of Examples 1 to 54 and the cosmetic compositions of Comparative Examples 1 to 4 were provided to the same subjects, and they were used alternately every day, and after 4 days, Survival was assessed.

3. Results

The results of evaluation of feelings for the cosmetic compositions of Examples and Comparative Examples are shown in Table 9, and the moisture persistence evaluation is shown in Table 10.

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 5 25 5 25 4 20 3 15 5 25 6 30 5 25 4 20 3 15 Good (4) 5 25 7 35 7 35 8 40 7 35 5 25 5 25 4 20 7 35 Usually (3) 10 50 8 40 8 40 9 45 8 40 9 45 10 50 12 60 10 50 Poor (2) - - - - One 5 - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 10 Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 Example 17 Example 18 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 5 25 8 40 7 35 6 30 10 50 10 50 11 55 8 40 5 25 Good (4) 7 35 8 40 3 15 3 15 8 40 7 35 8 40 2 10 7 35 Usually (3) 8 40 4 20 10 50 11 55 2 10 3 15 One 5 10 50 8 40 Poor (2) - - - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 19 Example 20 Example 21 Example 22 Example 23 Example 24 Example 25 Example 26 Example 27 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 4 20 5 25 5 25 8 40 5 25 6 30 4 20 4 20 5 25 Good (4) 7 35 3 15 7 35 8 40 4 20 5 25 7 35 8 40 7 35 Usually (3) 8 40 11 55 8 40 3 15 11 55 9 45 9 45 8 40 8 40 Poor (2) One 5 One 5 - - One 5 - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 28 Example 29 Example 30 Example 31 Example 32 Example 33 Example 34 Example 35 Example 36 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 8 40 10 50 10 50 9 45 15 75 10 50 12 60 11 55 10 50 Good (4) 8 40 5 25 6 30 8 40 3 15 6 30 4 20 9 45 10 50 Usually (3) 4 20 5 05 4 20 3 15 2 10 4 20 4 20 - - - - Poor (2) - - - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 37 Example 38 Example 39 Example 40 Example 41 Example 42 Example 43 Example 44 Example 45 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 10 50 6 30 10 50 15 75 16 80 15 75 10 50 8 40 7 35 Good (4) 10 50 12 60 7 35 3 15 3 15 2 10 8 40 10 50 12 60 Usually (3) - - 2 10 3 15 2 10 One 5 3 15 2 10 2 10 One 5 Poor (2) - - - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 46 Example 47 Example 48 Example 49 Example 50 Example 51 Example 52 Example 53 Example 54 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 4 20 10 50 7 35 10 50 8 40 5 25 7 35 6 30 7 35 Good (4) 7 35 10 50 12 60 10 50 9 45 4 20 12 60 5 25 5 25 Usually (3) 9 45 - - One 5 - - 3 15 11 55 One 5 9 45 8 40 Poor (2) - - - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Control Non-treatment persons % persons % persons % persons % persons % persons % Very good (5) 4 20 6 30 6 30 5 25 0 0 - - Good (4) 6 30 5 25 5 25 7 35 One 5 - - Usually (3) 9 45 9 45 9 45 8 40 2 10 - - Poor (2) One 5 - - - - - - 15 75 - - Very bad (One) - - - - - - - - 2 10 - -

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 5 25 5 25 5 25 4 20 5 25 6 30 6 30 4 20 3 15 Good (4) 6 30 8 40 6 30 7 35 8 40 5 25 4 20 3 15 8 40 Usually (3) 9 45 7 35 8 40 9 45 7 35 8 40 10 50 13 65 9 45 Poor (2) - - - - One 5 - - - - One 5 - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 10 Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 Example 17 Example 18 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 5 25 9 45 8 40 7 35 11 55 9 45 12 60 8 40 6 30 Good (4) 7 35 7 35 2 10 4 20 8 40 7 35 8 40 2 10 7 35 Usually (3) 7 35 4 20 10 50 11 55 3 11 4 20 - - 10 50 7 35 Poor (2) One One - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 19 Example 20 Example 21 Example 22 Example 23 Example 24 Example 25 Example 26 Example 27 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 5 25 6 30 5 25 8 40 5 25 6 30 5 25 4 20 5 25 Good (4) 6 30 3 15 7 35 8 40 5 25 5 25 6 30 8 40 7 35 Usually (3) 8 40 11 55 8 40 4 20 10 50 8 40 9 45 8 40 8 40 Poor (2) One 5 - - - - - - - - One 5 - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 28 Example 29 Example 30 Example 31 Example 32 Example 33 Example 34 Example 35 Example 36 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 9 45 10 50 10 50 9 45 15 75 10 50 12 60 11 55 10 50 Good (4) 7 35 5 25 5 25 8 40 2 10 6 30 5 25 9 45 10 50 Usually (3) 4 20 5 05 5 25 3 15 3 15 4 20 3 15 - - - - Poor (2) - - - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 37 Example 38 Example 39 Example 40 Example 41 Example 42 Example 43 Example 44 Example 45 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 10 50 6 30 10 50 14 70 18 90 16 80 10 50 9 45 8 40 Good (4) 8 40 13 65 7 35 4 20 One 5 2 10 8 40 11 55 11 55 Usually (3) 2 10 One 5 3 15 2 10 One 5 2 10 2 10 - - One 5 Poor (2) - - - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Example 46 Example 47 Example 48 Example 49 Example 50 Example 51 Example 52 Example 53 Example 54 persons % persons % persons % persons % persons % persons % persons % persons % persons % Very good (5) 4 20 9 45 7 35 10 50 8 40 6 30 7 35 5 20 7 35 Good (4) 8 40 11 55 11 55 10 50 10 50 4 20 11 55 6 30 5 25 Usually (3) 8 40 - - 2 10 - - 2 10 10 50 2 10 9 45 8 40 Poor (2) - - - - - - - - - - - - - - - - - - Very bad (One) - - - - - - - - - - - - - - - - - - Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Control Non-treatment persons % persons % persons % persons % persons % persons % Very good (5) 3 15 6 30 6 30 5 25 0 0 - - Good (4) 6 30 4 20 5 25 6 30 One 5 - - Usually (3) 9 45 10 50 9 45 9 45 3 15 - - Poor (2) 2 10 - - - - - - 15 75 - - Very bad (One) - - - - - - - - One 5 - -

As shown in Tables 9 and 10, the cosmetic composition of Example 41 of the present invention showed the best results in terms of feeling and water holding ability, and the cosmetic compositions of all the Examples were significantly higher than those of the comparative cosmetic compositions and the control cosmetic compositions . The cosmetic compositions of Examples 1 to 54 were compared with the cosmetic compositions of Comparative Examples 1 to 4 and the control group. As a result, in terms of types of ceramide generally mixed, the mixture of ceramide 3 and ceramide 6, ceramide 3 and ceramide 5 , A mixture of ceramide 2 and ceramide 5, a mixture of ceramide 5 and ceramide 6, a mixture of ceramide 2 and ceramide 6, and a mixture of ceramide 2 and ceramide 3 in that order. When they were mixed at a ratio of 4: 1 to 1: 4 on the weight basis, they showed a higher score compared with the case of not.

Claims (10)

And a surfactant which increases the solubility of the ceramide in the purified water,
The ceramide may be a mixture of two or more ceramides selected from the group comprising Ceramide EOP, Ceramide NS, Ceramide NP, Ceramide AS, and Ceramide AP Ceramide
A cosmetic composition comprising a mixed ceramide.
The method according to claim 1,
The mixed ceramides are a mixture of ceramide 2 and ceramide 3, a mixture of ceramide 2 and ceramide 5, a mixture of ceramide 2 and ceramide 6, a mixture of ceramide 3 and ceramide 5, a mixture of ceramide 3 and ceramide 6, and a mixture of ceramide 5 and ceramide 6 Wherein the cosmetic composition is a mixture selected from the group consisting of a cosmetic composition and a cosmetic composition.
3. The method of claim 2,
Wherein the mixture is a mixture of ceramides in a ratio of 1: 4 to 4: 1 by weight.
The method according to claim 1,
Wherein the mixed ceramide comprises 100 parts by weight of the mixed ceramide and 10-200 parts by weight of a surfactant having at least two alkyl chains attached to the hydrophilic part based on 100 parts by weight of the mixed ceramide. Cosmetic composition.
5. The method of claim 4,
Wherein the surfactant is lecithin-based egg yolk lecithin or soybean lecithin.
6. The method of claim 5,
Wherein the lecithin is hydrogenated lecithin.

The method according to claim 6,
Wherein the mixed ceramide further comprises a fatty acid present between the surfactant and the mixed ceramide.
8. The method of claim 7,
Wherein the fatty acid is selected from the group consisting of oleic acid, linoleic acid, behenic acid, arachidonic acid, stearic acid, palmitic acid, myristic acid and lauric acid and 10-1000 parts by weight based on 100 parts by weight of the mixed ceramide ≪ / RTI >
A method for preparing a cosmetic composition comprising a mixed ceramide comprising the steps of:
(a) mixing a surfactant having two or more alkyl chains attached to a hydrophilic moiety and a polar organic solvent having two or more OH groups;
(b) raising the temperature of the mixture of step (a) to raise the fluidity of the mixture;
(c) Ceramides as a poorly soluble substance in the mixture of step (b) are selected from a mixture of ceramide 2 and ceramide 3, a mixture of ceramide 2 and ceramide 5, a mixture of ceramide 2 and ceramide 6, a mixture of ceramide 3 and ceramide 5, 3 and a mixture of ceramides 6 and a mixture of ceramides 5 and ceramides 6;
(d) mixing and mixing the mixed ceramic mixture of step (c) with a mixer including a mixed blade structure having a concept of mixing the mixture; And
(e) solidifying the re-mixed mixture of step (d).
10. The method of claim 9,
Wherein the mixed ceramides are mixed in a ratio of 1: 4 to 4: 1 by weight of each of the ceramides.

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