KR20190022247A - Method for the Preparation of Cosmetic Composition Comprising Mixed Ceramides and Cosmetic Composition Prepared by the Same - Google Patents

Abstract

The present invention relates to a hydrophilic ceramide complex comprising ceramides. The hydrophilic ceramide complex comprises mixed ceramides including ceramide EOP, ceramide NS, ceramide NP, ceramide AS, and ceramide AP. A cosmetic composition including the hydrophilic ceramide complex of the present invention has a remarkably excellent texture and moisture. In addition, the hydrophilic ceramide complex of the present invention can increase the amount of ceramides dissolved by tens to hundreds times compared to conventional methods of solubilizing ceramides in a liposome form or emulsion form.

Description

[0001] The present invention relates to a method for producing a cosmetic composition containing a mixed ceramide, and a cosmetic composition prepared by the method.

The present invention relates to a method for producing a cosmetic composition comprising a mixed ceramide and a cosmetic composition prepared by the method. More particularly, the present invention relates to a cosmetic composition comprising ceramide EOP, ceramide NS, ceramide NP, (Ceramide AS) and Ceramide AP (Ceramide AP). ≪ Desc / Clms Page number 2 >

Ceramide is a naturally occurring sphingolipid compound, specifically N-palmityl sphingosine represented by the following formula (1). Ceramides are characterized by the presence of an amino group in the fatty acid radical.

[Chemical Formula 1]

Ceramide is produced mainly by the hydrolysis of sphingomyelinase (SMase) from sphingomyelin (SM), a kind of cell membrane phospholipid, Is a major polar lipid component that forms a lipid bilayer membrane together with moisture to provide moisture and barrier functions.

The surface of human skin is differentiated from the basal layer and protected by keratinocytes, which are degraded keratinocytes. These keratinocytes are formed by the double-chain lamellar structure of ceramides existing in the stratum corneum, So that the elasticity of the skin can be maintained. That is, the ceramides are arranged side by side in a layered structure, and water is filled and held therebetween, so that the layered structure exerts the overall barrier function.

However, as age ages, as the skin ages, the amount of ceramide in the stratum corneum decreases, which reduces the ability of the keratinocytes to bind to the skin surface, thus rendering the skin unprotected. That is, as the content of ceramides in the stratum corneum decreases, exposure to external stimuli such as loss of moisture, ultraviolet rays or chemicals, and exfoliation of the keratinocyte occur and the surface of the skin becomes rough.

In addition, the relationship between the health of the skin and the sphingolipid is very close in the light of the fact that abnormal ceramide levels (sphingolipids deficiency) are commonly observed in atopic eczema, dermatitis and psoriasis.

In light of the foregoing, it is very important to maintain a high level of ceramide in the skin in order to maintain and promote healthy skin.

Research has shown that ceramides can be restored to normal state by restoring the lamellar structure of the skin by supplementing ceramides from the outside in the academia, and ceramides not only supply moisture to the skin, It is known that it has a moisturizing effect that prevents the skin barrier from being damaged. As it is known that this helps the recovery of damaged skin barrier, ceramide is widely used as a main ingredient of functional cosmetics, skin and hair moisturizer.

However, ceramide is a poorly soluble substance and is dissolved only in an oil-soluble substance at a high temperature of 120 or more, making it difficult to use it as a cosmetic composition. Particularly, since the solubility of the purified water, which is the most basic raw material of cosmetic materials, is greatly reduced, it is not used at all in the cosmetics for cosmetics and cosmetics, and it is known that cosmetic ingredients can not be prepared only by the oil component .

Conventionally, a method of liposomizing natural lecithin using a high-pressure hydraulic device (microfluidizer) has been devised in order to solve the difficulty of such ceramides. However, since ceramide is encapsulated in a very fine liposome formed of a lecithin film, And only about 0.1-3.0 wt.% Of the cosmetic composition is contained in the cosmetic composition, and it is impossible to contain a large amount of ceramide.

In addition, there is a method of producing a cosmetic composition containing a large amount of ceramide by using a solvent having a high polarity or emulsifying it through a surfactant. However, a highly polar solvent such as C12-14 alkylbenzoate or octyldodecanol has a feeling of use And thus there is a problem in that there is a risk of skin irritation when a surfactant is used.

In order to solve the above-mentioned problems, in KR Patent Application No. 10-2012-0089886 (entitled "Untreated Sphing Pitch Feed"), 100 parts by weight of a sphingolipid as an insoluble substance and 100 parts by weight of an alkyl Wherein the amount of the surfactant is in the range of 10-200 parts by weight based on the sphingolipids, and the surfactant has a shape in which the outer periphery of the sphingolipids is amorphously surrounded and adhered Characterized in that an average diameter of the sphingolipids attached to the surfactant is 0.5-30 mu m and an average range of the size is within ± 200% of the diameter of the emulsion. .

However, in the case of the cosmetic composition contained in the above-mentioned patent documents, the problem of water dispersion of ceramides could be almost completely solved, but there still remains a part to be improved in terms of specific use feeling of the cosmetic composition.

Numerous papers and patent documents are referenced and cited throughout this specification. The disclosures of the cited papers and patent documents are incorporated herein by reference in their entirety to better understand the state of the art to which the present invention pertains and the content of the present invention.

The inventors of the present invention have found that, in the case of a ceramide cosmetic composition prepared by using an existing in-line mixer, the emulsion stability of the cosmetic composition is excellent, but it is necessary to improve the use feeling of a specific cosmetic composition, In order to maximize the feeling of use of the composition, a lot of research was done. As a result, the inventors of the present invention discovered that the use of five kinds of ceramides and cholesterol at a proper ratio can significantly improve the feeling as compared with a cosmetic composition containing only a single kind of ceramide.

Accordingly, an object of the present invention is to provide a cosmetic composition containing a mixed ceramide.

Another object of the present invention is to provide a method for producing a cosmetic composition containing mixed ceramides.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

The present invention provides a cosmetic composition.

The inventors of the present invention have found that, in the case of a ceramide cosmetic composition prepared by using an existing in-line mixer, the emulsion stability of the cosmetic composition is excellent, but it is necessary to improve the use feeling of a specific cosmetic composition, In order to maximize the feeling of use of the composition, a lot of research was done. As a result, it was confirmed that the use of five types of ceramide and cholesterol at a proper ratio can significantly improve the sensation of use as compared with the cosmetic composition containing only a single kind of ceramide.

According to one aspect of the present invention, there is provided a hydrophilic ceramide complex comprising ceramide, wherein said hydrophilic ceramide complex is selected from the group consisting of Ceramide EOP, Ceramide NS, Ceramide NP, , Ceramide AS (Ceramide AS), and Ceramide AP (Ceramide AP).

The term " hydrophilic, water soluble, soluble or dissolvable " as used herein refers to conventional dissolution, emulsification, liposomal and KR Patent Application No. 10-2012-0027176 ), KR Patent Application No. 10-2012-0027177 (entitled "Abrasive Interphase Material Containing a Fatty Acid Having a Linear Alkyl Chain"), KR Patent Application No. 10-2012-0027174 And non-woven interfacial material states used in KR Patent Application No. 10-2012-0027175 (entitled " Anhydrous Permanent Interfacial Substance ").

The term " poorly soluble " as used herein may mean that the pharmacologically active agent is not dissolved in an aqueous solution (e.g. water, physiological saline, injectable dextrose solution, etc.). USP / NF generally expresses solubility as the volume of solvent needed to dissolve 1 gram of drug at a specific temperature (eg, 1 g of aspirin in 300 ml of H2O, 25 ml of 5 ml of ethanol).

According to a preferred embodiment of the present invention, the mixed ceramides of the present invention preferably contain 100 parts by weight of ceramide NP, 0.0001-1 parts by weight of ceramide EOP, 1-30 parts by weight of ceramide NS, 1-10 parts by weight of ceramide AP and 1-10 parts by weight of ceramide AP.

In the present invention, it is a very important constitution to include various kinds of ceramides in the above-mentioned ratio. For this reason, it has been found that the use feeling and moisturizing power of the cosmetic composition can be remarkably improved when a large number of experiments show that Ceramide NP, Ceramide EOP, Ceramide NS, Ceramide AS and Ceramide AS are contained at the above-mentioned ratios.

According to a preferred embodiment of the present invention, the mixed ceramide complex of the present invention may additionally contain 0.1-30 parts by weight of cholesterol.

The addition of cholesterol at the above-mentioned ratios in the present invention is a very important constitution. For this reason, many experiments have found that when 0.1 to 30 parts by weight of cholesterol is additionally contained, the feeling and moisturizing power can be significantly improved as compared with the case of no addition.

In the present invention, the mixed ceramide may be made water-soluble by the hydrophilic part of the surfactant or the emulsifier in a state where the outer periphery is amorphously bound and adhered by a surfactant or an emulsifier.

According to a preferred embodiment of the present invention, the surfactant or emulsifier may be selected from a variety of surfactants or emulsifiers used in the art, but preferably a surfactant or emulsifier having two or more alkyl chains can be used, Lecithin or hydrogenated lecithin may be used as the phospholipid, and lecithin may be most preferably used.

According to a preferred embodiment of the present invention, the surfactant may be a natural surfactant or a synthetic surfactant.

Natural surfactants include at least one interface selected from the group comprising soy lecithin, egg lecithin, hydrogenated lecithin (hydrogenated soy lecithin and hydrogenated egg lecithin), sphingosine, ganglioside and phytosphingosine But are not limited thereto.

Natural lecithin is a mixture of diglycerides of stearic acid, palmitic acid and oleic acid linked to a choline ester of phosphoric acid, commonly referred to as phosphatidylcholine, and can be obtained from a variety of sources such as eggs and soybeans. Soybean lecithin and egg lecithin (including hydrogenated lecithin) have long been safe in biological systems, have both emulsifying and solubilizing properties, and tend to degrade faster than most synthetic surfactants in a more harmless way. Commercially available soybean lecithins include Centrophase and Centrolex products [Central Soya], Phospholipon [Phospholipid GmbH, Germany], Lipoid [Lipoid GmbH, Germany] and EPIKURON [Degussa].

Hydrogenated lecithin is the product of controlled hydrogenation of lecithin and may be included in the technical idea of the present invention.

According to the USP, lecithin is composed of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphotidylinositol, mixed with various substances such as triglycerides, fatty acids and carbohydrates in various amounts. Acetone-insoluble phospholipids.

Pharmaceutically, lecithin is primarily used as a dispersant, emulsifier and stabilizer, and is included in intramuscular and intravenous injections, parenteral nutritional formulations and topical products. Lecithin is also listed in the FDA Inactive Ingredients Guide for inhalants, IM and IV injections, oral capsules, suspensions and tablets, rectal preparations, topical preparations and vaginal preparations.

According to a preferred embodiment of the present invention, the content of the surfactant or emulsifier may be 10-200 parts by weight, more preferably 20-80 parts by weight, based on 100 parts by weight of the mixed ceramides , And most preferably 40-60 parts by weight. In the case of conventional liposomes, 5-10% of surfactant is used to dissolve 1.0% of ceramide. In the case of the hydrophilic ceramide complex according to the present invention, however, only 0.2-1.0% of surfactant is used to dissolve 1% It has the advantage of being easily dissolved in water.

According to a preferred embodiment of the present invention, the size of the hydrophilic ceramide complex is preferably 0.5-30 mu m, more preferably 1-10 mu m, and most preferably 1.5-5 mu m.

The size of the hydrophilic ceramide complex of the present invention is very important in terms of the function of dissolving the poorly soluble substance. Because the hydrophobic group of the surfactant is an important factor in determining the amount of poorly soluble material that can be present.

According to a preferred embodiment of the present invention, the average range of the size of the hydrophilic ceramide complex of the present invention is preferably -200% to 200%, more preferably -30% to 30%, and most preferably, -10% to 10%. High homogeneity is a very important component that significantly slows the recrystallization of the hydrophilic ceramide complex.

The precise mechanism of whether the recrystallization is delayed when the homogeneity is high is not yet fully understood. However, it is presumed that the van der Waals attraction between the hydrophilic ceramide composite particles produced by the method of the present invention is canceled by the repulsive force due to the mutual zeta potential between the hydrophilic ceramide composite particles, and the recrystallization is delayed.

As described above, in order to increase the homogeneity of the hydrophilic ceramide complex of the present invention remarkably, an inline mixer including mixed blend structure having the concept of blending and mixing should be used.

In this specification, the term " compensation mixture " means that the liquid passing through the separator is divided into 2 ⁿ , 3 ⁿ , 4 ⁿ and 5 ⁿ , By passing through a portion of the channel disposed within the gap in which the number of not more than 10 blades, preferably not more than 4, is repeatedly turned and fixed, the solution is conceptually cut off And the like.

According to a preferred embodiment of the present invention, the hydrophilic ceramide complex may further include a fatty acid present between the surfactant and the mixed ceramide. Although the fatty acid is not an essential component, the fatty acid is irregularly entangled with the alkyl chain of the surfactant attached to the mixed ceramide, thereby interfering with the surfactant to formulate, so that the mixed ceramides bond to each other and the probability of recrystallization is significantly lowered. In addition, since fatty acid melts well in the molten state, adding ceramide to the mixture with the surfactant can help increase the dispersion and homogeneity of the ceramide.

According to a preferred embodiment of the present invention, the fatty acid is preferably selected from the group including, but not limited to, stearic acid, palmitic acid, myristic acid and lauric acid.

According to a preferred embodiment of the present invention, the fatty acid may include 1-1000 parts by weight, more preferably 10-500 parts by weight, and most preferably 20-100 parts by weight, relative to the mixed ceramides can do.

According to another aspect of the present invention, there is provided a cosmetic composition comprising the hydrophilic ceramide complex.

The cosmetic composition of the present invention may contain other components besides the hydrophilic ceramide complexes described above. According to an embodiment of the present invention, the cosmetic composition of the present invention is obtained from the group comprising glycerin, butylene glycol, polyoxyethylene hydrogenated castor oil, tocopheryl acetate, citric acid, panthenol, squalane, sodium citrate and allantoin Further comprising at least one auxiliary component selected from the group consisting of glycerin, polyoxyethylene hydrogenated castor oil, tocopheryl acetate, squalane and sodium citrate, and at least one auxiliary ingredient selected from the group consisting of butylene glycol, citric acid, panthenol and allantoin And most preferably at least one component selected from the group consisting of glycerin, butylene glycol, polyoxyethylene hydrogenated castor oil, tocopheryl acetate, citric acid, panthenol, squalane, sodium citrate and allantoin .

Since the cosmetic composition of the present invention is basically applied to the skin, it can be provided with reference to the cosmetic composition of the related art, for example, as a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, But are not limited to, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays. More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Crystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

According to another aspect of the present invention, the present invention provides a process for preparing a hydrophilic ceramide complex comprising the steps of: (a) adding a surfactant having two or more alkyl chains attached to the hydrophilic moiety and a Of a polar organic solvent; (b) raising the temperature of the mixture of step (a) to raise the fluidity of the mixture; (c) 100 parts by weight of ceramide NP as a poorly soluble substance in the mixture of step (b), 0.0001-1 parts by weight of ceramide EOP, 1-30 parts by weight of ceramide NS, And 1-10 parts by weight of ceramide AP; (d) blending and mixing the mixture with the composite ceramide in step (c) using a mixer including a mixed blade structure having the concept of blending and mixing; And (e) solidifying the re-mixed mixture of step (d).

The features and advantages of the present invention are summarized as follows:

(a) The present invention relates to a hydrophilic ceramide complex comprising ceramide, wherein said hydrophilic ceramide complex is selected from the group consisting of Ceramide EOP, Ceramide NS, Ceramide NP, Ceramide AS, AS) and ceramide AP (Ceramide AP).

(b) The cosmetic composition comprising the hydrophilic ceramide complex of the present invention has a remarkably excellent feeling of use and moisturizing power.

(c) The hydrophilic ceramide complex of the present invention is advantageous in that the content of soluble ceramide can be increased to several tens to several hundred times as compared with a method in which ceramide is solubilized in the conventional liposome form or emulsion form.

1 shows a schematic diagram of an in-line mixer according to an embodiment of the present invention.
Figure 2 shows a partial cross-sectional view of the inline mixer shown in Figure 1;
3 is a perspective view for explaining the structure of the blade shown in Fig.
4 shows SEM photographs of the hydrophilic ceramide complex prepared by the method of Example 1 of the present invention and ceramide as a control. In the photograph, 1000 and 7000 represent the SEM magnification.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not to be construed as limiting the scope of the present invention. It will be self-evident.

Example

Throughout this specification, "%" used to denote the concentration of a particular substance is intended to include solids / solids (wt / wt), solid / liquid (wt / The liquid / liquid is (vol / vol)%.

Manufacturing example

Production Example 1: Preparation of hydrophilic ceramide complex

The compositions of Table 1 below were prepared by dispersing relatively stable ceramide and dipropylene glycol at high temperatures in a first open tank and adding glyceryl stearate and stearic acid, which required pre-mixing with hydrogenated lecithin, hydrogenated lecithin, After mixing with stirring, the solutions of the first open tank and the second open tank were stirred and mixed by an inline mixer to prepare the hydrophilic ceramide complexes of Example 1 and Comparative Example 1.

ingredient Example 1
(weight%) Comparative Example 1
(weight%) Ceramide Ceramide EOP One - Ceramide NS 3 - Ceramide NP 30 40 Ceramide AS One - Ceramide AP One - cholesterol 4 - Hydrogenated lecithin (PC 75%) 20 20 Stearic acid 10 10 Dipropylene glycol 20 20 Glyceryl stearate 10 10

Production Example 2: Preparation of cosmetic composition containing hydrophilic ceramide complex

Production Example 2-1: Preparation of a flexible lotion containing a hydrophilic ceramide complex

Formulation examples of the flexible lotion in cosmetics containing the hydrophilic ceramide complex of Production Example 1 of the present invention are as follows.

ingredient Example 2
(weight%) Comparative Example 2
(weight%) Example 1 A hydrophilic ceramide complex 0.5 - Comparative Example 1 A hydrophilic ceramide complex - 0.5 1,3-butylene glycol 5.2 5.2 Oleyl alcohol 1.5 1.5 ethanol 3.2 3.2 Polysorbate 20 3.2 3.2 Benzophenone-9 2.0 2.0 Carboxyl vinyl polymer 1.0 1.0 glycerin 3.5 3.5 incense a very small amount a very small amount antiseptic a very small amount a very small amount Purified water Balance Balance system 100 100

Production Example 2-2: Preparation of Milk Lotion Containing Hydrophilic Ceramide Complex

A formulation example of a milk lotion among cosmetics containing the hydrophilic ceramide complex of Production Example 1 of the present invention is as follows.

ingredient Example 3
(weight%) Comparative Example 3
(weight%) Example 1 A hydrophilic ceramide complex 0.6 - Comparative Example 1 A hydrophilic ceramide complex - 0.6 glycerin 5.1 5.1 Propylene glycol 4.2 4.2 Tocopheryl acetate 3.0 3.0 Liquid paraffin 4.6 4.6 Triethanolamine 1.0 1.0 Squalane 3.1 3.1 Macadamia nut oil 2.5 2.5 Polysorbate 60 1.6 1.6 Sorbitan sesquiterate 1.6 1.6 Propylparaben 0.6 0.6 Carboxyl vinyl polymer 1.5 1.5 incense a very small amount a very small amount antiseptic a very small amount a very small amount Purified water Balance Balance system 100 100

Production Example 2-3: Preparation of nutritional cream containing hydrophilic ceramide complex

Formulation examples of the nutritional cream among the cosmetics containing the hydrophilic ceramide complex of Production Example 1 of the present invention are as follows.

ingredient Example 4
(weight%) Comparative Example 4
(weight%) Example 1 A hydrophilic ceramide complex 1.0 - Comparative Example 1 A hydrophilic ceramide complex - 1.0 glycerin 4.0 4.0 vaseline 3.5 3.5 Triethanolamine 2.1 2.1 Liquid paraffin 5.3 5.3 Squalane 3.0 3.0 Wax 2.6 2.6 Tocopheryl acetate 5.4 5.4 Polysorbate 60 3.2 3.2 Carboxyl vinyl polymer 1.0 1.0 Sorbitan sesquioleate 3.1 3.1 incense a very small amount a very small amount antiseptic a very small amount a very small amount Purified water Balance Balance system 100 100

Preparation Example 2-2: Preparation of a massage cream containing a hydrophilic ceramide complex

A formulation example of a massage cream in cosmetics containing the hydrophilic ceramide complex of Production Example 1 of the present invention is as follows.

ingredient Example 5
(weight%) Comparative Example 5
(weight%) Example 1 A hydrophilic ceramide complex 0.5 - Comparative Example 1 A hydrophilic ceramide complex - 0.5 glycerin 4.0 4.0 vaseline 3.5 3.5 Triethanolamine 0.5 0.5 Liquid paraffin 24.0 24.0 Squalane 3.0 3.0 Wax 2.1 2.1 Tocopheryl acetate 0.1 0.1 Polysorbate 60 2.4 2.4 Carboxyl vinyl polymer 1.0 1.0 Sorbitan sesquioleate 2.3 2.3 incense a very small amount a very small amount antiseptic a very small amount a very small amount Purified water Balance Balance system 100 100

Experimental Example

Experimental Example 1: Evaluation of physical properties of hydrophilic ceramide complex

[

Experimental Example 1-1: Identification of amorphous state

The hydrophilic ceramide complex prepared by the method of Example 1 was hydrated, and the amorphous state was confirmed using a scanning electron microscope (SEM). The photographs were taken at a magnification of 7000 times and 1000 times, and specific results are shown in FIG. The picture shown in blue in Figure 4 is the ceramide itself, which shows that it is arranged very regularly as shown. By the ceramide crystals of regular arrangement, they are not dispersed in water and even if they are dispersed by physical force for a moment, they are in a condition where recrystallization occurs. However, it was confirmed that the amorphous crystals were irregularly dispersed in the photographs of the results of Example 1, which were obtained by photographing with a red color photographed by a scanning electron microscope. The amorphous form of the ceramide and the irregular arrangement of the crystals make water dispersion very easy and maintain a water dispersed state for a long time (more than 3 years at room temperature).

Experimental Example 1-2: Evaluation of homogeneity and dispersibility of hydrophilic ceramide complex

The method of measuring the dispersibility, homogeneity and particle size of the hydrophilic ceramide complex prepared by the method of Example 1 can be roughly determined by measuring the potential difference using a Zeta-Potential Analyzer, There is a limit in confirming the presence or absence of recrystallization. Therefore, the size and homogeneity of emulsified particles according to aging changes were confirmed directly by using a microscope, and its stability was confirmed. Referring to Table 4, it can be seen that the agglomeration phenomenon by recrystallization does not appear when the particle size according to aging changes shows a constant distribution of 2.6-3.8 탆.

Manufacturing method Particle size (쨉 m) After 1 day After 7 days After 1 month Three months later 1 year later Two years later Example 1 2.65-3.61 2.73-3.51 2.64-3.21 2.7-3.24 3.24-3.76 3.32-3.67

EXPERIMENTAL EXAMPLE 2 Evaluation of Feeling of Cosmetic Composition

In order to confirm the effect of the feeling of use and the duration of the cosmetic composition which gives the feeling of use improvement and duration time increasing effect to the cosmetic according to the present invention, the human body experiment was carried out as follows.

1. Subject and Period

In this experiment, 20 women aged 20 to 40 years were included in the study. The duration of the experiment was 5 days.

2. Experimental Method

A total of 20 subjects were each given a cosmetic composition prepared by the method of Example 3 and Comparative Example 3, and scored on the feeling of use. In addition, 10 ml of each of Example 3 and Comparative Example 3 were provided to the same subjects, which were used alternately every day, and a questionnaire was conducted on each water holding power after 4 days.

3. Results

Table 7 shows the evaluation results of the feeling for use in Example 1 and Comparative Example 1, and Table 8 shows the moisture persistence evaluation.

division Feeling (persons) (%) Example 3 Very good (5) 10 50.0 Good (4) 8 40.0 Usually (3) 2 10.0 Poor (2) 2 10.0 Very bad (1) - - Comparative Example 3 Very good (5) 2 10.0 Good (4) 4 20.0 Usually (3) 10 50.0 Poor (2) 2 10.0 Very bad (1) 2 10.0

division Feeling (persons) (%) Example 3 Very good (5) 12 60.0 Good (4) 6 30.0 Usually (3) One 5.0 Poor (2) One 5.0 Very bad (1) - - Comparative Example 3 Very good (5) One 5.0 Good (4) 10 50.0 Usually (3) 5 25.0 Poor (2) 2 10.0 Very bad (1) 2 10.0

As shown in Table 7, 90% or more of the subjects gave more than 4 points to the cosmetic composition according to Example 3 of the present invention, whereas only 30% gave 4 points or more to the subjects of Comparative Example 3, Was significantly higher than that of Comparative Example 3. Further, in the case of the water holding strength, not less than 4 points were given to not less than 90% of the cosmetic composition according to Example 3, while not less than 4 points were given only to 55% of Comparative Example 3. As a result, It was confirmed that the durability of water when using the composition was remarkably improved as compared with Comparative Example 3.

Structure and function of inline mixer

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 is a flow diagram of an emulsifying apparatus according to an embodiment of the present invention.

1, the emulsification apparatus 1 according to the embodiment of the present invention includes an inline mixer 10, an emulsification tank 20, an inflow pipe 30, circulation pipes 40 and 50, a circulation valve 41 A pump 60, a discharge pipe 70, a discharge valve 71, and a mixer 80. [

A mixture C to be emulsified is accommodated in the emulsion tank 20. An inflow pipe 30 is connected to the upper side of the emulsifying tank 20 so that the mixture C or the like as described above can be introduced into the emulsifying tank 20.

Circulation pipes 40 and 50 are connected to the lower side and the upper side of the emulsification tank 20. The circulation pipes 40 and 50 are provided with an inline mixer 10, a circulation valve 41 and a pump 60.

The circulation valve 41 is provided in the circulation pipe 40 connected to the lower side of the emulsification tank 20 so that the mixture C flows or does not flow through the circulation pipe 40 when the circulation valve 41 is opened or closed .

The mixer 80 may be installed below the emulsifying tank 20 as shown. The mixer 80 can be used in a case where the degree of homogenization of the mixture C introduced into the emulsion tank 20 through the inlet pipe 30 is extremely low, that is, when a relatively large solid or liquid particle exists in the mixture C, Can be reduced.

The discharge pipe 70 is connected to the lower side of the emulsifying tank 20 and the discharge pipe 70 is provided with a discharge valve 71. When the discharge valve 71 is opened after the completion of the emulsification for the mixture C, the emulsified mixture C can be discharged to the outside of the emulsion tank 20 through the discharge pipe 70.

When the circulation valve 41 is opened and the pump 60 is operated, the mixture C is circulated through the circulation pipe 40 connecting the lower side of the emulsification tank 20 and one side of the inline mixer 10 to the inline mixer 10 ). The mixture C having passed through the inline mixer 10 flows into the emulsion tank 20 through the circulation pipe 50 connecting the upper side of the emulsion tank 20 and the other side of the inline mixer 20.

The inline mixer 10 reduces the particle size of the material contained in the passing mixture C, while at the same time allowing the size of the reduced particles to be uniform. To this end, the in-line mixer 10 may include flow division, rotational circulation, and radial mixing, etc., in the flow of the mixture C while the mixture C passes through the inline mixer 10 .

The emulsifying apparatus 1 having the above-described connection relationship is operated as follows.

First, the mixture C to be emulsified is introduced into the emulsion tank 20 through the inlet pipe 30, and then the mixer 80 is operated as necessary to increase the mixing ratio of the mixture C, C to be reduced in size.

Thereafter, when the circulation valve 41 is opened and the pump 60 is operated, the mixture C passes through the circulation pipe 40 through the inline mixer 10 and then flows into the emulsion tank 20 through the circulation pipe 50 Circulated. Thus, the mixture C is repeatedly passed through the inline mixer 10 to increase the degree of emulsification.

If it is determined that the mixture C has been sufficiently emulsified, the operation of the pump 60 is stopped and the circulation valve 41 is shut off. Then, the discharge valve 71 is opened to emulsify the mixture C through the discharge pipe 70 To be discharged.

Thus, the mixture C can be emulsified by the emulsification apparatus 1 to have a very high homogeneity.

The inline mixer 10 may have a channel resistance of a certain level or more in order to sufficiently generate the surface division, the redirection, and the blending in the flow of the mixture C in the inline mixer 10. [

Therefore, the pump 60 should be able to apply a sufficient discharge pressure to the mixture C flowing into the inline mixer 10 through the circulation pipe 40 and prevent backflow. A plunger pump or a gear pump may be used as the pump 60 for this purpose. The plunger pump and gear pump are well known and will not be described further.

Fig. 2 is a partial sectional view of the inline mixer shown in Fig. 1, and Fig. 3 is a perspective view for explaining the structure of the blade shown in Fig. 2 and Fig. 3 together. Fig.

Referring first to Fig. 2, the inline mixer includes a blade 11 and a pressure-resistant pipe 12.

The pressure-resistant tube 12 is a hollow tube manufactured to withstand a high pressure, and both ends are coupled to the circulation tube as shown in FIG. In this case, the inline mixer 10 may be detachably coupled to the circulation pipe 10 in order to replace the inline mixer 10 for reasons such as aging of the inline mixer 10.

The blade (11) is disposed in the pressure-resistant pipe (12).

The blade 11 includes a plurality of unit blades 11a arranged in a row in the pressure vessel 12 as shown in the figure and the unitary blade 11a includes a first element 110 and a second element 120 .

3, the first element 110 includes a first element body 111 and the first element body 111 has a front edge 112, a rear edge 113, and a pair of side edges 114).

Here, the front and rear are based on the direction in which the mixture C flows into the inline mixer 10 (Fig. 1). The direction in which the mixture C flows is referred to as forward, and the mixture C flows The direction of going is called rear.

The first element body 111 has a rectangular member having four sides of a front edge 112, a rear edge 113 and a pair of opposite side edges 114 facing each other on a pair of opposite sides, (A) with a first center line (not shown) connecting the center points of the front and rear edges 113, 112 and the rear edge 113 as the central axis.

In other words, the first element body 111 has a unidirectional twisted shape indicated by A in the drawing as it goes from the front edge 112 toward the rear edge 113 in the figure.

Here, the side edge 114 is formed so as to be in contact with the inner peripheral surface of the pressure-resistant tube 12 when the first element body 111 is disposed in the pressure- Therefore, the first element body 111 forms a flow path in the pressure-resistant tube 12 having a spiral shape in the A direction with respect to the flow direction of the mixture C.

The second element 120 includes a second element body 121 and the second element body 121 includes a forward edge 122, a rear edge 123 and a pair of side edges 124.

The second element body 121 has a pair of opposite sides, that is, a front edge 122, a rear edge 123, and a rectangular member having four sides of a pair of side edges 124, And a second center line (not shown) connecting the center points of the rear edge 123 and the rear edge 123 as a center axis.

In other words, the second element body 121 has a unidirectional twisted shape indicated by B in the drawing as it goes from the front edge 122 toward the rear edge 123 in the figure.

Here, the side edge 124 is formed so as to be in contact with the inner peripheral surface of the pressure-resistant tube 12 when the second element body 121 is disposed in the pressure- Therefore, the second element body 121 forms a flow path in the pressure-resistant tube 12 having a helical shape in the direction B with respect to the flow direction of the mixture C.

Meanwhile, the first element 110 and the second element 120 may be coupled to each other.

The first element 110 and the second element 120 are configured such that a first centerline (not shown) of the first element 110 and a second centerline (not shown) of the second element 120 are shown And the rear edge 113 of the first element body 111 and the front edge 122 of the second element body 121 are in contact with each other, Lt; / RTI >

At this time, the rear edge 113 and the front edge 122 are disposed to intersect with each other. In other words, the rear edge 113 and the front edge 122 are arranged to form an angle rather than being arranged side by side.

The angle formed by the front edges 112 and 122 and the rear edges 113 and 123, that is, the degree of twist of the rear edges 113 and 123 with respect to the front edges 112 and 122, respectively, can be arbitrarily selected.

Experiments have shown that the mixing efficiency of the mixture C is high when the rear edges 113 and 123 are formed at 90 to 180 degrees with respect to the front edges 112 and 122, The angle at which the first element body 111 is twisted in the A direction and the angle at which the second element body 121 is twisted in the B direction can be 180 degrees.

The angle formed by the rear edge 113 and the front edge 122 when the first element 110 and the second element 120 are connected may also be arbitrarily selected. The first element 110 and the second element 120 may be arranged such that the rear edge 113 and the front edge 122 are connected to form a 90 degree or vertical shape.

In the present specification, 'parallelism' and 'vertical' do not mean mathematically 'parallelism' and 'verticalness' but 'parallelism' and 'verticalness' .

On the other hand, as described above, the blade 11 includes a plurality of unit blades 11a. Accordingly, the blade 11 has a structure in which the first element 110 and the second element 120 are alternately arranged in a line.

That is, the rear edge 123 of the second element 120 is connected to the front edge 112 of the first element 110 again. As a result of the experiment, in this case also, when the front edge 112 connected to the rear edge 123 is vertically formed and arranged to be connected, since the emulsification efficiency of the mixture C is the highest, the blade 11 has the first element The rear edge 113 of the second element 120 and the front edge 122 of the second element 120 and the front edge 112 of the first element 110 and the rear edge 123 of the second element 120 are both orthogonal Can be arranged continuously.

F shown by a dotted line in Fig. 2 represents a part of the flow of the mixture (C).

Here, F is surface division by F1 and F2 during the flow due to the arrangement structure of the first element 110 and the second element 120 as described above, and this surface division occurs along the longitudinal direction of the blade 11 The mixture C is continuously generated in the course of flowing in the direction indicated by the straight arrow.

Therefore, the mixture C is repeatedly mixed and separated in the course of passing through the inline mixer (10 of FIG. 9), so that the degree of homogenization of the mixture C, that is, the mixing state, is increased.

As described with reference to Fig. 3, since the direction A and the direction B are opposite to each other, the mixture C rotates in the direction A and the direction B in the course of flowing along the blade 11 I repeat. In other words, the mixture C repeats the one-directional rotation and the other-directional rotation about the axis parallel to the longitudinal direction of the blade 11 while passing through the inline mixer (10 in FIG. 9).

Therefore, the mixture (C) is redirected a number of times, and the mixture (C) is mixed due to inertia, so that the degree of emulsification of the mixture (C) becomes extremely high.

Therefore, the mixture C passes through the in-line mixer 10, and the components constituting the mixture C, for example, the above-mentioned organic poorly soluble substance, the solvent capable of dissolving the poorly soluble substance, and the surfactant are fine A very small particle shape having a uniform size is formed, and an emulsified state having high homogeneity and stability is obtained.

1: Emulsification device 10: Inline mixer
11: blade 11a: unit blade
110: first element 111: first element body
112: front edge 113: rear edge
114: lateral edge 120: second element
121: second element body 122: front edge
123: rear edge 124: lateral edge
12: pressure-resistant pipe 20: emulsification tank
30: inlet pipe 40, 50: circulation pipe
41: circulation valve 60: pump
70: discharge pipe 71: discharge valve
80: Mixer

Claims (14)

In a hydrophilic ceramide complex comprising a ceramide,
The hydrophilic ceramide complex comprises a hydrophilic ceramide complex comprising a mixed ceramide comprising Ceramide EOP, Ceramide NS, Ceramide NP, Ceramide AS and Ceramide AP. .
The method according to claim 1,
The mixed ceramides are preferably 100 parts by weight of ceramide NP, 0.0001-1 parts by weight of ceramide EOP, 1-30 parts by weight of ceramide ESI, 1-10 parts by weight of ceramide AS, and 1-10 parts by weight of ceramide AP 1-10 By weight of the hydrophilic ceramide complex.
3. The method of claim 2,
Wherein the mixed ceramide complex further comprises 0.1 to 30 parts by weight of cholesterol.
The method of claim 3,
Wherein the hydrophilic ceramide complex comprises 100 parts by weight of the mixed ceramide and 10-200 parts by weight of a surfactant having two or more alkyl chains attached to the hydrophilic part based on 100 parts by weight of the mixed ceramide.
5. The method of claim 4,
Wherein the surfactant is in an emulsion type and is dissolved in water to form an outer shape of the hydrophilic ceramide complex, and the hydrophilic ceramide complex attached to the surfactant has an average diameter of 0.5 to 30 탆, Characterized in that the mean size range is within ± 200% of the diameter reference.
6. The method of claim 5,
Wherein the hydrophilic ceramide complex further comprises a fatty acid present between the surfactant and the mixed ceramide.
The method according to claim 6,
Wherein the fatty acid comprises 10 to 1000 parts by weight based on 100 parts by weight of the mixed ceramide.
8. The method according to any one of claims 6 to 7,
Wherein the fatty acid is selected from the group consisting of oleic acid, linoleic acid, behenic acid, arachidonic acid, stearic acid, palmitic acid, myristic acid and lauric acid.
5. The method of claim 4,
Wherein the surfactant is lecithin-based egg yolk lecithin or soybean lecithin.
10. The method of claim 9,
Wherein the lecithin is a hydrogenated lecithin.
10. A cosmetic composition comprising the hydrophilic ceramide complex according to any one of claims 1 to 10.
A process for preparing a hydrophilic ceramide complex comprising the steps of:
(a) mixing a surfactant having two or more alkyl chains attached to a hydrophilic moiety and a polar organic solvent having two or more OH groups;
(b) raising the temperature of the mixture of step (a) to raise the fluidity of the mixture;
(c) 100 parts by weight of ceramide NP as a poorly soluble substance in the mixture of step (b), 0.0001-1 parts by weight of ceramide EOP, 1-30 parts by weight of ceramide NS, And 1-10 parts by weight of ceramide AP;
(d) blending and mixing the mixture with the composite ceramide in step (c) using a mixer including a mixed blade structure having the concept of blending and mixing; And
(e) solidifying the re-mixed mixture of step (d).
13. The method of claim 12,
Wherein the number of blades of the unitary blades constituting the blended blade structure is 10 or less.
13. The method of claim 12,
Wherein the number of unit blades constituting the blended blade structure is 5-30. ≪ RTI ID = 0.0 > 11. < / RTI >

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