KR102253879B1 - Polyurethane foam dressing comprising silver-activated carbon composites and producing method thereof - Google Patents

Abstract

The present invention relates to an antimicrobial polyurethane foam dressing material that helps wound healing by protecting wound areas such as wounds and burns, and in particular, to a polyurethane foam dressing material containing a silver-activated carbon composite as an antibacterial component, and a manufacturing method thereof. will be. In the present invention, a microporous polyurethane foam layer containing a silver-activated carbon composite obtained by impregnating activated carbon in a silver nitrate solution and then heat treatment under an inert gas as an antibacterial active ingredient; A polyurethane film layer that is attached to the upper surface of the foam layer and is water-permeable and waterproof; It provides an antimicrobial polyurethane foam dressing material comprising a perforated polyurethane film layer attached to the lower surface of the foam layer and in contact with the wound surface. In the dressing material of the present invention, since the antimicrobial silver particles are stably distributed in the dual structure of the porous activated carbon and the microporous foam layer, when applied to a wound, the release of the antimicrobial silver particles is not largely influenced by the amount of exudate and a small amount of exudate. In both cases and large amounts of exudate, release occurs continuously and stably.

Description

Polyurethane foam dressing comprising silver-activated carbon composites and producing method thereof

The present invention relates to an antimicrobial polyurethane foam dressing material that helps wound healing while protecting wound areas such as wounds and burns, and in particular, to a polyurethane foam dressing material containing a silver-activated carbon composite as an antibacterial component, and a manufacturing method thereof. will be.

In the early 1970s, Rovee published a study showing that creating an environment that does not form a crust by maintaining a moist environment moves epithelial cells to the wound and promotes epithelial regeneration. Subsequently, in the case of open wounds, research results show that the movement of epithelial cells is suppressed by collagen formed in the skin layer, and the wound fluid eliminates several types of growth factors that stimulate angiogenesis and epithelialization. Supported the theory.

As described above, the moist environment helps regenerative epithelial cells to develop smoothly along the wound surface, but in a dry environment, since they cannot develop along the wound surface, the restoration of the wound is delayed and the wound healing proceeds inefficiently. In addition, since the substances involved in wound healing contained in the exudate can smoothly perform their roles in a humid environment, wound healing proceeds efficiently.

The major factors involved in wound healing include humidity, temperature, infection, and oxygen concentration. The ideal dressing material should maintain a moist environment between the wound and the dressing material, have adequate absorbency and moisture permeability, prevent dryness of the wound surface, and do not cause infiltration (salt) of the surrounding normal skin. In addition, it has the function of exchanging gas and preventing bacterial invasion from the outside, and should not stick to the wound surface so as not to damage new tissues during exchange.

Wet environment dressing materials that are currently commonly used can be classified into polyurethane foam, hydrocolloid, hydrogel, and semi-permeable film dressing materials. Among them, polyurethane foam is mainly used for deep wounds or wounds where a large amount of exudate occurs because polyurethane foam has excellent exudate absorption ability, easy exchange, and has a cushion to protect wounds. However, even if the exudate absorption capacity is excellent and the moist environment composition is excellent, there is a problem in that secondary infection may occur when applied to a wound that has become infected or is susceptible to infection.

Infection is a factor that directly affects wound healing. In tissues containing a large number of bacteria, the movement of epithelial cells is not smooth and the inflammation continues for a long time and healing is delayed. In addition, infection is a side effect that can occur even when care is not taken during dressing exchange or treatment, or when contaminated areas are not completely disinfected and treated.

In order to solve this infection problem, Korean Patent Registration No. 10-1377569 discloses an antimicrobial wound coating material and a method for manufacturing the same, and Korean Patent Publication No. 10-2016-0035129 discloses a wound coating composition for sustained release of an antimicrobial material and a wound. Disclosed is a method of manufacturing a covering material. In addition, dressing materials having different drug release rates depending on the film type have also been developed.

However, in the case of a polyurethane foam dressing material containing a conventional drug, it is not easy to control drug release, so if the drug is released excessively, there is a concern of wasting the drug and skin irritation, and if the exudate is small, the release is not smooth and the drug is effective. There is a problem that is difficult to represent.

Republic of Korea Patent Publication No. 10-2005-0073771 Republic of Korea Patent Publication No. 10-2007-0111758 Republic of Korea Patent Publication No. 10-2016-0035129 Korean Patent Registration No. 10-0676937 Korean Patent Registration No. 10-0859626 Korean Patent Registration No. 10-1377569 Korean Patent Registration No. 10-1414020 Korean Patent Registration No. 10-1426740 Korean Patent Registration No. 10-1022884

The present invention is to solve the problems of the conventional antimicrobial dressing material as described above, in the present invention, instead of the existing antimicrobial drug as an antibacterial component, a self-developed silver-activated carbon composite is applied to a polyurethane foam dressing material. In particular, in the present invention, the amount or wound of exudate is contained in the foam layer in the middle of the dressing material having a moisture-permeable and waterproof polyurethane film layer at the upper part and a perforated polyurethane film layer at the lower part, centering on the microporous foam layer. It is an object of the present invention to provide an antimicrobial polyurethane foam dressing material capable of consistently exhibiting antibacterial effects while adequately maintaining the dissolution of antimicrobial silver without being greatly affected by the environment of

In order to achieve the above object, in the present invention,

A microporous polyurethane foam layer containing a silver-activated carbon composite obtained by impregnating activated carbon in a silver nitrate solution and then heat-treating under an inert gas as an antibacterial active ingredient;

A polyurethane film layer that is attached to the upper surface of the foam layer and is water-permeable and waterproof;

It provides an antimicrobial polyurethane foam dressing material comprising a perforated polyurethane film layer attached to the lower surface of the foam layer and in contact with the wound surface.

The silver-activated carbon composite is preferably obtained by impregnating activated carbon in a silver nitrate solution having a concentration of 1 to 20 mol/L and then heat-treating at 100 to 500° C. for 10 minutes to 8 hours under an inert gas.

remind It is preferable that the inert gas is a mixture of hydrogen and nitrogen.

The polyurethane foam layer is preferably obtained by foaming a mixture of 100 parts by weight of a polyurethane prepolymer and 30 to 150 parts by weight of a foam composition to a predetermined thickness and foam molding, preferably having a thickness of 1 to 15 mm.

The foamed composition contains water and a crosslinking agent, and contains a silver-activated carbon composite in an amount of 0.01 to 8% by weight of the total weight of the composition.

In addition, in the present invention,

(a) comprising water and a crosslinking agent and at the same time making a foamed composition by including a silver-activated carbon composite in an amount of 0.01 to 8% by weight of the total weight;

(b) preparing a foaming mixture by mixing 100 parts by weight of a polyurethane prepolymer and 30 to 150 parts by weight of the foaming composition;

(c) forming a microporous antimicrobial polyurethane foam layer by applying the foaming mixture to a certain thickness on a release paper and foaming;

(d) adding a solvent to the polyurethane resin in which the hydrophilic group has been introduced into the main chain, followed by stirring, applying to a release paper, and drying to form a non-porous water-permeable waterproof polyurethane film layer;

(e) obtaining a non-porous moisture-permeable and waterproof polyurethane film layer in the same manner as in step (d), and then making a perforated polyurethane film layer by perforating to form a through hole; And

(f) The polyurethane foam layer obtained in step (c) has tackiness before it is completely cured, and the polyurethane film layer obtained in step (d) on the top and the perforated polyurethane film obtained in step (e) on the bottom. It provides a method of manufacturing an antimicrobial polyurethane foam dressing material comprising the step of laminating and placing a film layer.

The polyurethane foam dressing material of the present invention contains a'silver-activated carbon composite' obtained by impregnating activated carbon in a silver nitrate solution and then heat-treating under an inert gas in the middle foam layer as an antibacterial active ingredient. It is stably distributed within the double structure of the foam layer, and as a result, when applied to a wound, the release of antimicrobial silver particles is not largely influenced by the amount of exudate, and release is consistently and stably performed in both a small amount of exudate or a large amount of exudate. do. The foam dressing material of the present invention has a long duration while maintaining constant antibacterial properties and also has a deodorizing function, so that odors generated by bacteria can be removed, and it has good adhesion and has a small dimensional change rate. In addition, when the polyurethane foam layer containing the drug is molded, the upper polyurethane film layer and the lower perforated polyurethane film layer are laminated and laminated as they are, thereby increasing production efficiency and productivity.

1 is a schematic diagram of an antimicrobial polyurethane foam dressing material of the present invention.
Figure 2 is a schematic diagram of the manufacturing process of the dressing material of the present invention.

The antimicrobial polyurethane foam dressing material of the present invention includes a microporous polyurethane foam layer containing a silver-activated carbon composite as an antibacterial active ingredient; A polyurethane film layer that is attached to the upper surface of the foam layer and is water-permeable and waterproof; It includes a perforated polyurethane film layer attached to the lower surface of the foam layer and in contact with the wound surface. 1 is a schematic diagram of an antimicrobial polyurethane foam dressing material of the present invention.

Hereinafter, the configuration of the antimicrobial polyurethane foam dressing material will be described in more detail.

The polyurethane foam layer 20 is formed to be microporous, and contains a silver-activated carbon composite as an antibacterial active ingredient. In the present invention, the term'antibacterial carbon composite' is also used in the same meaning as'silver-activated carbon composite'.

The silver-activated carbon composite is obtained by impregnating activated carbon in a silver nitrate solution and then heat treatment under an inert gas. The silver-activated carbon composite is preferably obtained by impregnating activated carbon in a silver nitrate solution having a concentration of 1 to 20 mol/L and then heat-treating at 100 to 500° C. for 10 minutes to 8 hours under an inert gas. More preferably, the inert gas is a mixed gas of hydrogen and nitrogen, particularly preferably a mixed gas of 50% by volume of hydrogen and nitrogen.

The silver-activated carbon composite obtained after the heat treatment is in the form of a powder, and the silver particles are uniformly and stably distributed over a large surface area including pores of the porous activated carbon. Silver particles having antimicrobial properties are stably present on a large surface of the activated carbon, and this silver-activated carbon composite is again stably distributed in the pores of the microporous foam layer. Therefore, since the antimicrobial silver particles stably exist in such a double structure, when the dressing material is applied to the wound, even if there is only a small amount of exudate, the exudate flows into the foam layer and stays in contact with the silver-activated carbon complex to gradually release the silver particles. In addition, even when there are many exudates, there is no significant difference in the area of the exudate in contact with the silver-activated carbon composite in the foam layer, so the silver particles are gradually released at a uniform rate. In this way, in the dressing material of the present invention, since silver particles are stably distributed in a double structure of high-temperature-treated activated carbon and foam layer, the discharge of silver particles is uniformly and stably performed at a constant rate in all cases of small or large exudates.

The foam layer can be obtained by foaming and molding by applying a foaming mixture obtained by mixing 100 parts by weight of a polyurethane prepolymer and 30 to 150 parts by weight of a foam composition to a predetermined thickness. Preferably, the thickness of the foam layer is in the range of 1 to 15 mm. If it is thinner than 1mm, the absorption capacity of exudate may be lowered, and the carrying capacity of the drug and the uniformity of release may also decrease. In addition, if it is wider than 15mm, it becomes inconvenient to use due to a sense of volume, and the effect in terms of exudate absorption ability, drug bearing ability, and uniformity of release is not great compared to the increase in volume, so the utility is degraded.

The foamed composition used to form the foam layer preferably includes a silver-activated carbon composite in an amount of 0.01 to 8% by weight of the total weight of the composition together with water and a crosslinking agent. If it is less than 0.01% by weight, the antibacterial activity will fall. When used in an amount of 8% by weight or more, silver is released in excess of what is necessary for antibacterial activity, which is wasted and may adversely affect wounds, and even after the use of the dressing material, a large amount is not released and remains, so economical efficiency is degraded.

The polyurethane film layer 10 is formed of a polyurethane resin in which a hydrophilic group is introduced into the main chain to have moisture permeability and waterproofness at the same time, and is attached to the upper surface of the foam layer 20. The polyurethane film layer 10 forms the outside of the dressing material.

The perforated polyurethane film layer 30 is made of the same moisture-permeable and waterproof polyurethane film as the polyurethane film layer 10, and through holes are formed by perforations. The perforated polyurethane film layer 30 is attached to the lower surface of the foam layer 20. The perforated polyurethane film layer 30 comes into contact with the wound surface, and is perforated to facilitate the movement of exudate from the wound to the dressing material or the movement of the drug from the dressing material to the wound. Can be prevented from being attached to.

Hereinafter, a method of manufacturing the antimicrobial polyurethane foam dressing material of the present invention will be described for each layer according to a preferred embodiment.

1. Preparation of polyurethane foam layer

(1) Preparation of polyurethane prepolymer

Isocyanate is added to the mixed solution of polyol and diol and reacted to prepare a polyurethane prepolymer. A specific example of preparation of the polyurethane prepolymer is as follows. First, polyol and diol were added and the temperature was raised to 50°C while stirring at a stirring speed of about 150 RPM, then stirred for 30 minutes, and then isocyanate was added to react until the NCO content (%) reached the theoretical value in a nitrogen atmosphere. Let it.

The polyols include polypropylene oxide glycol, polyethylene oxide glycol, polytetramethylene ether glycol, ethylene oxide/propylene oxide copolymer, polytetrahydrofuran/ethylene oxide copolymer, polytetrahydrofuran/propylene oxide copolymer, polybutylene One or two or more selected from carbonate glycol, polyhexamethylene carbonate glycol, polycaprolactone glycol, polyethylene adipate, polybutylene adipate, polyneopentyl adipate, and polyhexamethylene adipate are mixed and used.

The polyurethane prepolymer used to prepare the polyurethane foam of the present invention is preferably a hydrophilic polyurethane prepolymer into which a hydrophilic group is introduced. The content of ethylene oxide, which is a hydrophilic group, is important for imparting hydrophilicity, which is known in "Journal of Cellular Plastics 1976; 12; 285" "Journal of Cellular Plastics 1983; 19; 259", U.S. Patent No. 4,008,189 (1975.11.4) and the like. You can refer to technology. It is particularly preferable to use an ethylene oxide/propylene oxide copolymer having two or more hydroxyl groups as a polyol and having an ethylene oxide content of 20 to 90% by weight with a molecular weight of 500 to 6,000.

Examples of the diol compound include ethylene glycol, propylene glycol, 1,3-butanediol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, triethylene glycol, diethylene glycol, tetraethylene glycol, Dipropylene glycol, dibutylene glycol, neopentyl glycol, 1,4-cyclohexanedimethanol, 2-methyl-1,3-pentanediol, and the like may be used alone or in combination of two or more. Preferably, one or two or more selected from ethylene glycol, propylene glycol and 1,4-butanediol are mixed and used.

As the isocyanate, aromatic, aliphatic and substituted isocyanates or mixtures thereof may be used. For example, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, methylene diphenyl diisocyanate, 1,5-naphthalene diisocyanate, toridine diisocyanate, hexamethylene-1,6-diisocyanate, isophorone One or two or more selected from diisocyanate, xylene diisocyanate, cyclohexylene-1,4-diisocyanate, lysine diisocyanate, and tetramethylene-xylene diisocyanate are used in combination. It is preferable to use isophorone diisocyanate, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate or methylenediphenyl isocyanate.

When preparing the polyurethane prepolymer, a known antioxidant may be added according to a known method. As antioxidants, phenyl-beta-naphthalamine, cysteine hydrochloride, dibutylhydroxytoluene, nordihydroguazaretic acid, butylhydroxyanisole, phosphoric acid, citric acid, ascorbic acid, erythorbic acid, propyl gallate, Ciba Specialty Chemicals' IRGANOX 1010, IRGANOX 1035, IRGANOX 1076, IRGANOX 1330, IRGANOX 1425WL, IRGANOX 3114, IRGANOX B215, IRGANOX B220, IRGANOX B225, IRGANOX B561, IRGANOX B313, IRGANOX B501GAW, IRGANOX B501GAW, IRGANOX B501GAX B PS800, IRGANOX PS802, IRGAFOS P-EPQ, etc. are used. Phosphoric acid, citric acid, dibutylhydroxytoluene, butylhydroxyanisole, IRGANOX 1010, IRGANOX 1035, IRGANOX 1076 and IRGANOX 1330 is preferably used in combination of one or two or more selected from. It is preferable to add the antioxidant in the range of 0.05 to 5% by weight of the total weight of the polyurethane prepolymer.

(2) Preparation of polyurethane foam composition containing drug

A foaming composition to be used as a foaming agent is prepared by mixing water and a crosslinking agent. The foamed composition preferably contains 60 to 120 parts by weight of deionized water, 0.5 to 40 parts by weight of a crosslinking agent, and 1 to 10 parts by weight of a surfactant, and at the same time, 0.01 to 8% by weight of the total weight of the foamed composition contains a silver-activated carbon composite. . In addition, the foamed composition may further include 0.01 to 2% by weight of a pigment, 0.01 to 20% by weight of a moisturizer, and 0.01 to 40% by weight of an absorption aid in the total weight, if necessary.

The crosslinking agent may be used by mixing one or two or more selected from glycerin, trimethylolpropane, 1,2,4-butanetriol, and sorbitol. The crosslinking agent plays a role in improving the mechanical properties of the foam through a crosslinking reaction when forming a polyurethane foam.

As the surfactant, a known surfactant may be used according to known uses and methods. For example, BASF's F-68, F-87, F-88, F-108, F-127, which are ethylene oxide/propylene oxide block copolymers, and L-580, L-603, L-688 as silicone surfactants , L-5420, SZ-1703, L-6900, L-3150, Y-7931, L-1580, L-5340, L-5333, L-6701, L-5740M, L-3002, L-626, etc. Can be used. Surfactant plays a role in controlling the pore size and opening rate of the polyurethane foam dressing material. In particular, BASF's F-68, an ethylene oxide/propylene oxide block copolymer, is most preferred because it helps to clean wounds without injuring tissues and is known to be non-toxic.

In the present invention, the moisturizing agent serves to prevent the formation of crusts by maintaining a moist environment on the wound surface and to facilitate wound healing. Therefore, in the present specification,'moisturizing agent' is used as a meaning to include a well-known moisturizing agent generally known as a moisturizing agent, as well as a wound healing aid that suppresses crust formation by maintaining a moist environment and facilitates wound healing. Examples of such moisturizers include propylene glycol alginate, methylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, sodium carboxymethyl starch, sodium alginate, ammonium alginate, potassium alginate, calcium alginate, sodium caseinate, guar gum, locust bean gum , Xanthan gum, cyclodextrin, gum arabic, gellan gum, carrageenan, karaya gum, casein, tara gum, tamarind gum, tragacanth gum, pectin, glucomannan, gati gum, arabinogalactan, purcelleran, pullulan , Glucosamine, carboxymethylcellulose, chitin, chitosan, sodium alginate, hyaluronic acid, amino acids, L-aspartic acid, L-aspartic acid sodium, DL-alanine, L-isoleucine, lysine hydrochloride, glycine, glycerin, L-glutamine, L- Glutamic acid, L-sodium glutamate, pyridic acid, L-threonine, sericin, serine, L-tyrosine, heparin, sodium chondroitin sulfate, sodium alginate, gelatin, etc. may be included in the foaming mixture within the above range.

In addition, the composition may contain an absorption aid such as a known super absorbent polymer within the above range in order to increase the absorbency of the polyurethane foam.

In addition, known additives with known efficacy, such as stabilizers, preservatives, and property modifiers, may be added in small amounts for known uses.

(3) Preparation of silver-activated carbon composite

The silver-activated carbon composite used as an antibacterial active ingredient in the present invention is obtained by impregnating activated carbon in a silver nitrate solution and then heat treatment under an inert gas.

Preferably, the activated carbon is impregnated in a silver nitrate solution having a concentration of 1 to 20 mol/L and then heat-treated at 100 to 500° C. for 10 minutes to 8 hours under an inert gas to obtain it. More preferably, the activated carbon is impregnated with silver nitrate and then heat-treated at a temperature of 150 to 400°C for 10 minutes to 5 hours under an inert gas to reduce the silver nitrate, and then the obtained silver-activated carbon composite is sufficient according to a conventional activated carbon washing method. It is obtained by washing with positive water. The inert gas is preferably a mixed gas of hydrogen and nitrogen, and particularly preferably a mixed gas of 50% by volume of hydrogen and nitrogen, respectively.

(3) Preparation of the polyurethane foam layer containing the drug

A foaming mixture is prepared by mixing 100 parts by weight of the polyurethane prepolymer and 30 to 150 parts by weight of the foaming composition. The prepared foaming mixture is applied on a release paper in a thickness ranging from 0.05 to 10 mm, foamed into a foam layer, and a polyurethane foam layer is obtained in a gel state with tack before being completely cured.

First, the foaming mixture stirred at high speed in the above step is applied to a release paper with a predetermined thickness using a coating gauge or the like. Then, after about 1 to 2 minutes elapse, the polyurethane foam layer is formed in a gel state with tactile properties.

The release paper is not particularly limited, but it is preferable to use a release paper treated with silicone.

The prepared polyurethane foam layer is not limited, but the thickness is preferably in the range of 0.1 to 10 mm, and particularly preferably in the range of 1.0 to 5.0 mm.

The prepared polyurethane foam layer becomes microporous after drying.

2. Preparation of moisture-permeable and waterproof polyurethane film layer

Add 20 to 70 parts by weight of methyl ethyl ketone and 5 to 30 parts by weight of dimethylformamide to 100 parts by weight of the polyurethane resin, stir, remove air bubbles, apply to a release paper, and dry to prepare a non-porous, moisture-permeable and waterproof polyurethane film layer do. If necessary, 1 to 10 parts by weight of a pigment may be further added to the polyurethane resin.

As a polyurethane resin, a polyurethane resin that has both moisture permeability and waterproof properties, that is, a polyurethane resin in which a hydrophilic group is introduced into the main chain like the polyurethane resin used to form the polyurethane foam layer is used, it has both moisture permeability and waterproof properties. A waterproof polyurethane film layer can be obtained.

The prepared moisture-permeable and waterproof polyurethane film layer forms the outside of the dressing material of the present invention.

The prepared moisture-permeable and waterproof polyurethane film layer is preferably in the range of 5 to 100 μm in thickness, and particularly preferably in the range of 15 to 25 μm.

3. Preparation of perforated polyurethane film layer

A moisture-permeable and waterproof polyurethane film layer was prepared in the same manner as in the preparation of the moisture-permeable and waterproof polyurethane film layer, and then perforated. The perforation was performed by the method disclosed in Patent No. 10-1414020 of the present applicant.

4. Lamination

The prepared moisture-permeable and waterproof polyurethane film layer, a polyurethane foam layer containing a drug, and a perforated polyurethane film layer are laminated. Preferably, a polyurethane film layer is placed on the upper portion of the polyurethane foam layer obtained in a tactile gel state, and a perforated polyurethane film layer is placed on the lower portion of the polyurethane foam layer and laminated. Figure 2 is a schematic diagram of the manufacturing process of the dressing material of the present invention. Laminating can be done at the same time or sequentially at the top and bottom.

As the lamination method, a known method such as a method of using a commonly used pressure-sensitive adhesive or an adhesive, and a method of applying pressure may also be used. However, preferably, a polyurethane film layer is placed on a gel-like polyurethane foam layer with tack before being completely cured without using a separate adhesive or pressure-sensitive adhesive, and then laminated as it is. At this time, the thickness of the polyurethane foam dressing material is adjusted by pressing with a certain gap. After lamination and drying, the polyurethane foam dressing material of the present invention is obtained.

Hereinafter, the present invention will be described in more detail through specific examples. However, the following examples are illustrative of the present invention, and the scope of the present invention is not limited to the following examples.

<Example 1>

(1) Direct application of perforated film when making polyurethane foam layer

The activated carbon was impregnated in a silver nitrate solution having a concentration of 5 mol/L, and then heat-treated at a temperature of 300° C. for 1 hour in an inert gas consisting of 50% hydrogen and 50% nitrogen based on the volume to prepare a silver-activated carbon composite. 80 g of deionized water, 1.5 g of crosslinking agent, 3 g of surfactant, 1.5 g of silver-activated carbon complex, 0.02 g of pigment, and 10 g of moisturizer were mixed to prepare a foamed composition. The prepolymer was prepared by the method of Synthesis Example 1 of Patent No. 10-0937816. A foaming mixture was prepared by mixing the prepolymer and the foaming composition in an amount of 100 parts by weight and 70 parts by weight, respectively.

The moisture-permeable and waterproof polyurethane film layer was made according to the'preparation example of a moisture-permeable and waterproof polyurethane film' of Patent No. 10-0937816. The thus-made moisture-permeable and waterproof polyurethane film was perforated according to the method of Registration Patent No. 10-1414020 to prepare a perforated polyurethane film layer.

As shown in the schematic diagram of the working process in FIG. 2, a polyurethane foam is formed by passing the perforated film on the release paper to which the foaming mixture is applied, and a polyurethane film layer is laminated on the upper portion of the antimicrobial polyurethane foam dressing of the present invention. Finished ashes. The cross-section of the prepared antimicrobial polyurethane foam dressing material is shown in FIG. 1.

<Experimental Example 1>

Physical property measurement

The physical properties of the antimicrobial polyurethane foam dressing material prepared in Example 1 were measured as follows.

① Exudate absorption (%)

The samples were taken in a size of 5cm×5cm, left at room temperature for 24 hours, and then the initial weight (A) was measured, and the samples were impregnated in distilled water at a constant temperature of 24 to 26°C and a relative humidity of 40 to 50% for 24 hours. After taking it out and wiping off the water on the surface, the weight (B) was measured. Finally, it was calculated using the following equation.

Absorption (%) = (B-A)/A × 100

② Exudate retention (%)

The samples were taken in a size of 5cm×5cm, left at room temperature for 24 hours, and then the initial weight (A) was measured, and the samples were impregnated in distilled water at a constant temperature of 24 to 26°C and a relative humidity of 40 to 50% for 24 hours. . After storage, take out, wipe off the water on the surface, spread it on a glass plate, and then store it in a thermo-hygrostat at a constant temperature of 36 to 38°C and a relative humidity of 40 to 50% for 2 hours, and then the weight (B) was measured. Finally, it was calculated using the following equation.

Retention (%) = (B-A)/A × 100

③ moisture permeability

The moisture permeability of the samples was measured according to EN 13726-1 using a thermo-hygrostat, and at this time, the temperature of the thermo-hygrostat was set to 37°C and the relative humidity was set to 20%.

The physical properties measured as described above are shown in Table 1 below.

division Absorption
(%) Retention
(%) Moisture permeability ^*
(g/m ² /day) Example 1 985 51 1,150 *: Condition = 37℃, 20% (EN-13726-2)

As can be seen from the results of Table 1 above, the antimicrobial polyurethane foam dressing material prepared according to the present invention contains a silver-activated carbon complex in a sufficient amount necessary for antibacterial action, while the existing dressing material in terms of absorption, retention, and moisture permeability. It showed excellent physical properties without any difference.

10: polyurethane film layer
20: polyurethane foam layer
30: perforated polyurethane film layer
40: Hyungji Lee

Claims (8)

(a) impregnating activated carbon in a silver nitrate solution having a concentration of 1 to 20 mol/L and heat treatment at 100 to 500° C. for 10 minutes to 8 hours under a mixed gas of hydrogen and nitrogen to obtain a silver-activated carbon composite;
(b) comprising water and a crosslinking agent and at the same time making a foamed composition by including the silver-activated carbon composite as an antibacterial active ingredient in an amount of 0.01 to 8% by weight of the total weight;
(c) preparing a foaming mixture by mixing 100 parts by weight of a polyurethane prepolymer and 30 to 150 parts by weight of the foaming composition;
(d) forming a microporous antimicrobial polyurethane foam layer by applying the foam mixture to a certain thickness on a release paper and foaming;
(e) adding a solvent to the polyurethane resin in which the hydrophilic group is introduced into the main chain, stirring, coating on a release paper, and drying to form a non-porous, moisture-permeable and waterproof polyurethane film layer;
(f) obtaining a non-porous water-permeable and waterproof polyurethane film layer in the same manner as in step (e), and then making a perforated polyurethane film layer by perforating to form a through hole; And
(g) In the state where the polyurethane foam layer obtained in step (d) has tackiness before it is completely cured, the polyurethane film layer obtained in step (e) on the top and the perforated polyurethane film obtained in step (f) on the bottom. It includes the step of laying and laminating the layers,
The silver-activated carbon composite is powdery, and silver particles are uniformly distributed over a surface area including pores of porous activated carbon. delete delete delete The method of claim 1,
The polyurethane foam layer is a method of manufacturing an antimicrobial polyurethane foam dressing material, characterized in that the thickness is 1 ~ 15mm. The method of claim 1,
The polyurethane foam layer further comprises a moisturizing agent,
The foaming composition is characterized in that it contains a moisturizing agent in 0.01 to 20% by weight of the total weight of the composition, the method of producing an antimicrobial polyurethane foam dressing material. The method of claim 6,
The moisturizing agent is propylene glycol alginate, methylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, sodium carboxymethyl starch, sodium alginate, ammonium alginate, potassium alginate, calcium alginate, sodium caseinate, guar gum, locust bean gum, xanthan gum, Cyclodextrin, gum arabic, gellan gum, carrageenan, gum karaya, casein, tara gum, tamarind gum, gum tragacanth, pectin, glucomannan, gati gum, arabinogalactan, purseleran, pullulan, glucosamine, Carboxymethylcellulose, chitin, chitosan, sodium alginate, hyaluronic acid, amino acids, L-aspartic acid, L-sodium aspartate, DL-alanine, L-isoleucine, lysine hydrochloride, glycine, glycerin, L-glutamine, L-glutamic acid, L- Sodium glutamate, pyritic acid, L-threonine, sericin, serine, L-tyrosine, heparin, sodium chondroitin sulfate, sodium alginate, gelatin, characterized in that at least one selected from, the method of producing an antimicrobial polyurethane foam dressing material. delete

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