KR102250171B1 - Liposomal cosmetic composition for moisturizing skin using organic farming materials - Google Patents

Abstract

The present invention relates to a liposome cosmetic composition for moisturizing the skin using organic raw materials. The cosmetic composition increases skin permeability to excellently increase a percutaneous absorption rate, and thus has excellent skin moisturizing effects.

Description

Liposomal cosmetic composition for moisturizing skin using organic farming materials}

The present invention relates to a cosmetic composition using organic raw materials, and to a liposomal cosmetic composition having excellent skin moisturizing effect.

The skin is in direct contact with the external environment and is responsible for protecting our body from various harmful factors. However, as the skin is damaged by age increase, ultraviolet rays, external harmful substances and stress, and the ability to protect and proliferate cells is weakened, skin aging is accelerated.

In general, the amount of moisture in the skin is about 70% in the dermis layer, but decreases toward the epidermis layer and becomes about 10 to 30% in the stratum corneum layer. Water supplied from the dermal layer moves to the upper part of the stratum corneum mainly by passive diffusion and is finally discharged to the outside. This is called transdermal moisture loss, and it is known that such transdermal moisture loss is maintained at an appropriate level by sebum components and epidermal lipids, which are lipid membrane components of the stratum corneum.

On the other hand, when the moisture of the stratum corneum layer is less than 10%, the skin becomes dry and skin aging occurs, because the moisture content of the stratum corneum layer is less than that of normal skin. In addition, the skin condition may worsen due to a lack of moisture due to harsh external environments such as wind, cold weather, sunlight, cleansing, and shaving. Therefore, it is important to properly maintain the moisture content of the stratum corneum cell layer of the skin.

Republic of Korea Patent Registration No. 10-1516063 (2015.04.22.) describes a cosmetic composition for moisturizing the skin containing a bellflower extract containing platicodine D as an active ingredient. Korean Patent Registration No. 10-0563442 (2006.03.16.) describes organic natural extracts having skin moisturizing and irritation alleviating effects, and a cosmetic composition containing the same.

The present invention is to provide a cosmetic composition having excellent skin moisturizing effect. In particular, the present invention is to provide a cosmetic composition without skin side effects or skin irritation by using organic raw materials.

An object of the present invention is to provide a cosmetic composition with increased transdermal absorption by minimizing the particle size.

The present invention is a step (a) of first emulsification by injecting the material dissolved in the second melting tank into the material dissolved in the first melting tank, homogenizing it with a homogenizer at 3,000 to 4,000 rpm for 2 to 4 minutes; And after the step (a), the step (b) of secondary emulsification for 3 to 5 minutes at 2,000 to 3,000 rpm; including, wherein the material dissolved in the second dissolving tank is capryl compared to the total component for nano-liposome production. It was prepared by adding 10 to 30 wt% of rick/capric triglyceride to the second dissolving tank and dissolving at 75 to 80°C, and the material dissolved in the first dissolving bath is green tea water compared to the total components for nano-liposome production. It provides a method for producing a nano-liposome, characterized in that it is prepared by adding 1 to 25% by weight and 50 to 85% by weight of glycerin to the first dissolving tank and mixing at 70 to 75°C.

In the present invention, the material dissolved in the second dissolving tank preferably further contains 2 to 20% by weight of hydrogenated lecithin relative to the total component for preparing nano-liposomes.

In addition, the present invention provides a cosmetic composition comprising a nano-liposome prepared by the above manufacturing method.

In the present invention, the cosmetic composition is preferably to increase the skin moisture content immediately after application.

The present invention provides a cosmetic composition excellent in skin moisturizing effect by excellently increasing the transdermal absorption rate by using a liposomal composition having increased skin permeability.

The present invention can provide a cosmetic composition without skin side effects or skin irritation by using organic raw materials.

1 is a photograph of the particle size of the nano-liposome according to the present invention.
FIG. 2 is a photograph of the particle size of nano-liposomes that have not undergone a secondary emulsification process.
3 is a summary of the results of an efficacy evaluation test for improving moisture content when the cosmetic composition according to the present invention is applied to the skin.
4 is a graph of test results showing that the moisture content is improved when the cosmetic composition according to the present invention is applied to the skin.

An object of the present invention is to provide a cosmetic composition for skin moisturizing, including preparing nano liposomes using organic raw materials. Specifically, the present invention is a step (a) of first emulsification by injecting the material dissolved in the second melting tank into the material dissolved in the first melting tank, homogenizing it with a homogenizer at 3,000-4,000 rpm for 2-4 minutes; And after the step (a), the step (b) of secondary emulsification for 3 to 5 minutes at 2,000 to 3,000 rpm; including, wherein the material dissolved in the second dissolving tank is capryl compared to the total component for nano-liposome production. It was prepared by adding 10 to 30 wt% of rick/capric triglyceride to the second dissolving tank and dissolving at 75 to 80°C, and the material dissolved in the first dissolving bath is green tea water compared to the total components for nano-liposome production. It provides a method for producing a nano-liposome, characterized in that it is prepared by adding 1 to 25% by weight and 50 to 85% by weight of glycerin to the first dissolving tank and mixing at 70 to 75°C.

In general, a cosmetic composition contains a large amount of purified water, but the present invention was intended to further impart its functionality by using green tea water having an antioxidant effect on the skin. Green tea is rich in flavonoids and is known to have antioxidant and anti-aging effects, and it is a more beneficial ingredient for the skin as it has the effect of relieving skin redness, skin heat sensation, and skin irritation.

Glycerin is a colorless, transparent and odorless substance that attracts moisture in the air and is used as a moisturizer for skin or hair.

Caprylic/capric triglyceride creates a protective film that blocks moisture evaporation, and is a raw material that is stable against oxidation and acts as a preservative.

The nano-liposome of the present invention dissolves the aqueous phase component and the oil phase component in a water phase dissolving tank (first dissolving tank) and an oil phase dissolving tank (second dissolution tank), and then mixing the oil phase component and the aqueous phase component, and using a homogenizer. First emulsify for 2 to 4 minutes at 3,000 to 4,000 rpm. After that, it is prepared by secondary emulsification for 3 to 5 minutes at 2,000 to 3,000 rpm.

The aqueous phase component is preferably dissolved at 70 to 75 °C, and the oily component is preferably dissolved at 75 to 80 °C. In addition, when the oil phase component and the aqueous phase component are mixed, the oil phase component and the aqueous phase component must be added while maintaining the temperature of the oil phase component at 75 to 80°C so that the oil phase component and the aqueous phase component can be easily mixed.

The second emulsification process is preferably performed using a high-pressure homogenizer. In this case, the high-pressure homogenizer may use, for example, a microfluidizer.

In the present invention, the material dissolved in the second dissolving tank preferably further contains 2 to 20% by weight of hydrogenated lecithin relative to the total component for preparing nano-liposomes. Hydrogenated lecithin is one of the phospholipids and is a substance used as an emulsifier. Lecithin is a major component of cells and can keep the skin moist.

In addition, the present invention provides a cosmetic composition comprising a nano-liposome prepared by the above manufacturing method.

In the present invention, the cosmetic composition is preferably to increase the skin moisture content immediately after application.

On the other hand, the present invention aims to prepare a skin-friendly cosmetic composition using organic raw materials, and improves skin permeability by minimizing the particle size, thereby providing a cosmetic composition having excellent moisturizing effect.

The cosmetic composition of the present invention contains nano-ized liposomes through a second homogenization (emulsification) process, and nano-liposomes have a particle size of 0.025 to 2.5 µm to further increase skin permeability, thereby further enhancing the skin moisturizing effect. have.

On the other hand, the cosmetic composition of the present invention, for example, solutions, suspensions, emulsions, pastes, lotions, gels, water-soluble liquids, creams, essences, surfactant-containing cleansing, oil, oil-in-water (O/W) type and water-in-oil Any one basic cosmetic formulation selected from (W/O) type; skin; Lotion; Eye cream; Soothing gel; Ointment; Formulations for mask packs; Formulation for body wash; Peeling gel; Water-in-water and water-in-oil makeup base; foundation; Skin cover; Any one color cosmetic formulation selected from lipstick, lip gloss, face powder, two-way cake, eye sado, cheek color, and eyebrow pencil; Formulation for scalp; It may be any one selected from among.

In addition, the cosmetic composition of the present invention may contain auxiliary agents commonly used in the technical field to which the present invention belongs, such as hydrophilic or lipophilic activators, preservatives, antioxidants, solvents, fragrances, fillers, blockers, pigments, odorants, dyes, etc. I can. The amounts of these various adjuvants are those commonly used in the art, such as 0.001 to 30% by weight based on the total weight of the composition. However, in any case, the adjuvant and its ratio will be selected so as not to adversely affect the desirable properties of the cosmetic composition according to the present invention.

On the other hand, in the cosmetic composition of the present invention, when the formulation is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, Benzoate, propylene glycol, 1,3-butylene glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of soribitan may be used.

In addition, in the cosmetic composition of the present invention, when the formulation is a suspension, a liquid diluent such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester as carrier components A suspending agent such as, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth, and the like may be used.

In addition, in the cosmetic composition of the present invention, when the formulation is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica as carrier components , Talc or zinc oxide may be used.

In addition, in the cosmetic composition of the present invention, when the formulation is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier function. In particular, in the case of a spray, Additionally, propellants such as chlorofluorohydrocarbon, propane/butane or dimethyl ether may be included.

In addition, in the cosmetic composition of the present invention, when the formulation is a surfactant-containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, sarcosinate, Fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters may be used.

In addition, the cosmetic composition of the present invention can be used in conjunction with other cosmetic compositions other than the present invention. In addition, the cosmetic composition according to the present invention may be used according to a conventional method of use, and the number of times of use thereof may be varied according to a user's skin condition or taste.

Hereinafter, the content of the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited to the following examples, and includes modifications of the technical idea equivalent thereto.

[Example 1: Preparation of nano liposomes using organic raw materials]

In this example, nano-liposomes were prepared by the blending ratio according to Table 1 below.

Example 1-1 Example 1-2 Example 1-3 Organic glycerin 68 60 56 Caprylic/Capric Triglyceride 18 20 20 Organic Green Tea Water 10 15 18 Hydrogenated Lecithin 4 5 6

The water-phase ingredients (organic glycerin, organic green tea water) were added to the water-water dissolving tank (the first dissolving tank), heated to 73°C, and mixed and dissolved with a mixer. The oily components (caprylic/capric triglyceride, hydrogenated lecithin) were added to an oily dissolving tank (second dissolving tank) and heated to 80°C to completely dissolve. While maintaining the temperature of the oil phase component at 75-80°C, it was put into an aqueous melting tank (the first melting tank) and first emulsified (homogenized) for 3 minutes at 3,000-4,000 rpm in a homogenizer. Then, using a microfluidizer, the second emulsification was performed at 60 to 70°C and 2,000 to 3,000 rpm for 3 to 5 minutes to prepare nano liposomes.

[Example 2: Preparation of liposomes using organic raw materials]

In this example, liposomes were prepared by the mixing ratio according to Table 1 below.

Example 2-1 Example 2-2 Example 2-3 Example 2-4 Organic glycerin 62 58 55 50 Caprylic/Capric Triglyceride 18 20 21 24 Organic Green Tea Water 10 10 10 10 Hydrogenated Lecithin 10 12 14 16

The aqueous phase component was added to the aqueous phase dissolving tank (first dissolving tank), heated to 73°C, and mixed and dissolved with a mixer. The oil phase component was added to the oil phase melting tank (second melting tank) and heated to 80°C to completely dissolve. While maintaining the temperature of the oil phase component at 75-80°C, it was put into an aqueous dissolving tank (first dissolving tank) and emulsified (homogenized) for 3 minutes at 3,000-4,000 rpm in a homogenizer to prepare liposomes.

[Experimental Example 1: Confirmation of particle size of liposome]

In this experiment, it was attempted to confirm the particle size of the cosmetic compositions prepared in Examples 1 and 2.

1 is a photograph of the particles of the nano-liposomal cosmetic composition of Example 1-1 of the present invention taken with DW-BHSP, and FIG. 2 is a photograph of the particles of the liposome cosmetic composition of Example 2-1 of the present invention as DW-BHSP. This is a picture I took.

1 and 2, it was confirmed that the particle size of the nano-liposomal cosmetic composition of Example 1-1 was significantly smaller than that of the liposomal cosmetic composition of Example 2-1. The particle size of FIG. 1 was found to be about 0.025 to 2.5 µm, and the particle size of FIG. 2 was found to be about 0.5 to 10.0 µm.

[Experimental Example 2: Confirmation of skin moisturizing effect of nano liposomes]

In this experiment, in order to confirm the skin moisturizing effect of the nano-liposome prepared in Example 1, 21 subjects in their 20s to 50s were analyzed for moisture content before and after application of the stratum corneum (Fig. 3).

As a result of the experiment, as shown in FIG. 4, the moisture content was 39.71% before applying the nano-liposome of Example 1-1, but after applying the nano-liposome of Example 1-1, the moisture content was 54.46%. Accordingly, it was confirmed that the moisture content of the skin was improved immediately after application of the nano-liposome of Example 1-1, and the moisture content was increased by 37.12%.

[Example 3: Preparation of a cosmetic composition containing a nano-liposome composition]

In this example, a cosmetic composition was prepared using the nano-liposome prepared in Example 1.

Raw material Content (% by weight)
Awards
Melting tank Purified water 61.50 Nano liposome (Example 1-1) 5.00 glycerin 10.00

Paid
Melting tank Caprylic/Capric Triglyceride 9.00 Shea Butter 3.00 Cetearyl alcohol 3.00 Glyceryl stearate 2.50 Cetearylolivate, sorbitanolivate 4.00 Beeswax 2.00

The aqueous phase component was added to the aqueous phase dissolving tank (first dissolving tank), heated to 75°C, and mixed and dissolved with a mixer. The oil phase component was added to the oil phase melting tank (second melting tank) and heated to 80°C to completely dissolve. While maintaining the temperature of the oil phase component at 75 ~ 80 ℃ put into an aqueous solution (first dissolution tank) and emulsified (homogenized) for 5 minutes at 2,500 ~ 3,000 rpm in a homogenizer to prepare a cosmetic composition containing nano-liposomes.

[Example 4: Preparation of a cosmetic composition containing a liposome composition]

In this example, a cosmetic composition was prepared using the nano-liposome prepared in Example 2.

Raw material Content (% by weight)
Awards
Melting tank Purified water 61.50 Liposomes (Example 2-1) 5.00 glycerin 10.00

Paid
Melting tank Caprylic/Capric Triglyceride 9.00 Shea Butter 3.00 Cetearyl alcohol 3.00 Glyceryl stearate 2.50 Cetearylolivate, sorbitanolivate 4.00 Beeswax 2.00

The aqueous phase component was added to the aqueous phase dissolving tank (first dissolving tank), heated to 75°C, and mixed and dissolved with a mixer. The oil phase component was added to the oil phase melting tank (second melting tank) and heated to 80°C to completely dissolve. While maintaining the temperature of the oil phase component at 75 ~ 80 ℃ put into the aqueous solution (first dissolution tank) and emulsified (homogenized) for 5 minutes at 2,500 ~ 3,000 rpm in a homogenizer to prepare a cosmetic composition containing liposomes.

[Experimental Example 3: Confirmation of moisturizing effect of nano liposome cosmetic composition]

In this experiment, in order to confirm the skin moisturizing effect of the cosmetic compositions prepared in Examples 3 and 4, the moisture content of the stratum corneum was analyzed before, 1 minute after application, and 5 minutes after application of the cosmetic composition. The moisture content was measured using MY-707S of scala company.

The experimental results are shown in FIG. 5. The moisture content of the stratum corneum before applying each cosmetic composition was 31.7%. Example 3 After 1 minute of application of the cosmetic composition, the moisture content was 41.8%, and after 5 minutes of application, the moisture content was 34.8%. Example 4 After 1 minute of application of the cosmetic composition, the moisture content was 38.4%, and after 5 minutes of application, the moisture content was 33.0%. Accordingly, it was confirmed that the moisturizing effect of Example 3 using nano-liposomes was more excellent, and it was confirmed that the moisture content of the skin was immediately improved after application.

In particular, as the particle size of the liposome was more finely homogenized, it was determined that the transdermal absorption rate was significantly improved by increasing the skin permeability of the liposome.

Claims (4)

(A) first emulsifying by injecting the material dissolved in the second melting tank into the material dissolved in the first melting tank while maintaining the dissolved material in the second melting tank at 75-80°C, homogenizing it with a homogenizer at 3,000-4,000 rpm for 2-4 minutes (a); And
After the step (a), a step (b) of secondary emulsification for 3 to 5 minutes at 60 to 70° C., 2,000 to 3,000 rpm; to prepare a nano liposome, including,
As for the material dissolved in the second dissolving bath, 18 to 20 wt% of caprylic/capric triglyceride and 4 to 6 wt% of hydrogenated lecithin were added to the second dissolving bath and 75 It is prepared by dissolving at ~80℃,
The material dissolved in the first dissolving tank is prepared by adding 10 to 18% by weight of green tea and 56 to 68% by weight of glycerin to the first dissolving bath and mixing at 70 to 75°C, relative to the total components for nano-liposome production,
The method of manufacturing a nano-liposome, characterized in that the particle size of the nano-liposome is 0.025 ~ 2.5㎛.
delete (A) first emulsifying by injecting the material dissolved in the second melting tank into the material dissolved in the first melting tank while maintaining the dissolved material in the second melting tank at 75-80°C, homogenizing it with a homogenizer at 3,000-4,000 rpm for 2-4 minutes (a); And
After the step (a), the step (b) of secondary emulsification for 3 to 5 minutes at 60 to 70° C., 2,000 to 3,000 rpm; including the process of preparing a nano-liposome having a particle size of 0.025 to 2.5 μm,
As for the material dissolved in the second dissolving bath, 18 to 20 wt% of caprylic/capric triglyceride and 4 to 6 wt% of hydrogenated lecithin were added to the second dissolving bath and 75 It is prepared by dissolving at ~80℃,
The material dissolved in the first dissolving tank is prepared by adding 10 to 18% by weight of green tea and 56 to 68% by weight of glycerin to the first dissolving bath and mixing at 70 to 75°C relative to the total components for nano-liposome production. Method for producing a cosmetic composition.
The method of claim 3,
The cosmetic composition,
A method for producing a cosmetic composition, characterized in that the moisture content of the skin is immediately increased after application of the skin.

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