KR102207603B1 - Composition for inducing sleep including pelargonium graveolens oil - Google Patents

Abstract

The present invention relates to a composition for inducing sleep comprising rose geranium essential oil, and is used as aromatherapy, and has excellent sleep induction effect for polysomnography.
In addition, it is possible to provide a perfume composition and an external composition for skin having excellent sleep inducing effect, including rose geranium essential oil.

Description

Composition for inducing sleep including pelargonium graveolens oil}

The present invention relates to a composition for inducing sleep comprising rose geranium essential oil, and more specifically, a fragrance composition comprising rose geranium essential oil, and has excellent sleep inducing effect.

Sleep is a state in which conscious activities are at rest with your eyes closed. This is an important process for replenishing the energy used by a person while active during the day and recovering from fatigue accumulated by physical activity. At the same time, it is the time in which the most essential growth hormone for human growth is secreted.

In addition, in order for the brain, which is a place that oversees all physiological functions for maintaining the life of our body, in order to maintain an appropriate balance of activities, it is necessary to rest, and most of these rests occur during sleep.

Recently, the American Thoracic and Cardiovascular Association recommended that adults sleep 6 to 9 hours per day.

However, the number of patients receiving treatment due to sleep problems caused by the exhausting and busy daily life of modern people and the aging of the population has been increasing in recent years and is expected to continue to increase in the future.

Sleep-related disorders directly harm health, and recent studies have shown that lack of sleep increases the risk of diabetes, heart disease, and obesity.

In a study published in 2004 in the journal'Sleep', on average, women who slept for less than 5 hours a night had a significantly higher mortality rate than women who slept for 7 hours.

Currently, in order to treat most sleep disorders, the administration of sleeping pills, mental stabilizers, and stress relievers is used as a general treatment.

However, long-term use of these drugs for 4 weeks or more shows problems of dependence and drug side effects, and administration of such drugs may be restricted in the case of the elderly or pregnant women.

In addition, as an experiment to measure the degree of sleep disorder, polysomnography is being conducted.

The polysomnography test not only 　sleep, but also 　sleep 　, examines several important body functions. In order to test the body's function in the sleep state, various sensors are attached to the body and the body is made to sleep. At this time, in the case of a sleep disorder patient, there is a problem that it is difficult to enter a smooth sleep state.

Therefore, there is a need to develop a fragrance composition capable of effectively improving the treatment of sleep disorders or the quality of sleep while having few side effects in addition to the above drugs, and exhibiting an effect of treating or improving usual sleep disorders with an aroma effect.

In addition, during the polysomnography test, it is necessary to develop a fragrance composition for transition to a smooth sleep state.

KR 10-2019-0061737 A1

It is an object of the present invention to provide a composition for inducing sleep comprising rose geranium essential oil.

Another object of the present invention is to provide a composition that is used as aromatherapy and has excellent sleep induction effect for polysomnography.

Another object of the present invention is to provide a perfume composition and a composition for external application for skin comprising rose geranium essential oil and having excellent sleep inducing effect.

In order to achieve the above object, the composition for inducing sleep comprising rose geranium essential oil according to an embodiment of the present invention includes essential oil of rose geranium (pelargonium graveolens), and the effect of preventing, improving or treating sleep disorders through sleep induction Is excellent.

The rose geranium essential oil is used as an aromatherapy, and has excellent sleep induction effect for polysomnography.

The sleep disorders are: sleep disorders, sleep disorders, severe arousal, early arousal, insomnia, nightmares, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep seizures, respiratory-related sleep disorders, apnea, circadian rhythm sleep It is selected from the group consisting of circadian rhythm sleep disorders, parasomnia, restless legs syndrome and periodic limb motility.

The composition may further include an extract of Juniperus rigida Siebold & Zucc.

The composition may include phenethyl alcohol, methyldihydrojasmonate and linalul.

A fragrance composition according to another embodiment of the present invention includes a composition for inducing sleep containing the rose geranium essential oil.

The composition for external application for skin according to another embodiment of the present invention includes a composition for inducing sleep including the rose geranium essential oil.

Hereinafter, the present invention will be described in more detail.

The composition for inducing sleep comprising rose geranium essential oil according to an embodiment of the present invention includes rose geranium (pelargonium graveolens) essential oil, and has excellent effects of preventing, improving or treating sleep disorders through sleep induction.

The rose geranium is a cultivar of herb geranium native to Egypt, and has a rose scent from leaves and stems. The generic name pelargonium means'pelargos', the Latin word for'stork', which is attributed to the seeds resembling a stork's beak. It is also called Gumuncho because it protects against mosquitoes with its unique fragrance. It grows to 30 to 60 cm in height. The stem is straight and covered with hair without pruning. The leaf is a pinnate compound leaf (water biplane), and it is deeply divided and the divided pieces are divided again, and there is a sawtooth at the edge. Pink or rose-colored flowers bloom from April to June and do not smell. Petals are covered with downy hair and veins are visible. The fruit is shaped like a bird's beak and has 5 chambers, each containing a seed.

The present invention is to provide a composition having excellent sleep induction effect, including the rose geranium essential oil.

The sleep disorders are more specifically, sleep disorders, sleep disorders, severe arousal, early awakening, insomnia, nightmares, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep seizures, respiratory-related sleep disorders, apnea, It may be selected from the group consisting of circadian rhythm sleep disorders, parasomnia, restless legs syndrome, and periodic limb motility.

In addition, the rose geranium essential oil is more specifically used as aromatherapy, and when used for polysomnography, the sleep inducing effect is very excellent.

As described above, the polysomnography tests not only sleep but also various important physical functions among 　sleep 　. In order to test the body's function in the sleep state, various sensors are attached to the body and the body is made to sleep. At this time, in the case of a sleep disorder patient, there is a problem that it is difficult to enter a smooth sleep state.

The polysomnography test is the latest state-of-the-art test that objectively evaluates the structure and function of sleep, and events occurring during sleep, and is a safe and painless test. The above test is an accurate and multi-dimensional test. During 8 to 10 hours of sleep, EEG, eye movement, lower jaw and lower extremity EMG, electrocardiogram, snoring, blood pressure, respiration, respiratory movement, oxygen saturation, etc. are continuously measured and recorded on a digital computer. At the same time, abnormal behaviors of the patient during sleep are recorded by digital video. It is a test to find a problem of a patient by reading the record over several hours by a sleep medicine specialist through a dedicated computer program.

During the test, for smooth sleep, you should not take a nap on the day of the test, and drinks containing caffeine such as coffee, black tea, cola, and green tea, alcohol, and cigarettes should be avoided. Finally, medications such as sleeping pills are prohibited the night before the test.

In addition to measuring the sleep quality of patients who wish to undergo polysomnography, it is a test that performs multiple tests simultaneously.To measure sleep quality, drinks and alcohol containing caffeine are strictly prohibited, and the use of drugs such as sleeping pills is also strictly prohibited. Is prohibited.

However, if you want to proceed with such a polysomnography test, you must sleep for 8 to 10 hours, and if you cannot switch to a smooth sleep state or fall asleep deeply, there is a problem that it is impossible to proceed with a smooth polysomnia test. .

In order to solve this problem, the present invention relates to a composition for preventing, improving or treating sleep disorders comprising rose geranium essential oil.

The rose geranium essential oil is used as aromatherapy and is provided to patients as aroma, and has excellent sleep induction effect due to effects such as heart rate stabilization, as well as psychological stability, and has an effect of preventing, improving or treating sleep disorders. I can.

Rosegeranium essential oil may be prepared using a conventional method for producing essential oil of essential oil, and more specifically, may be prepared by extraction through steam distillation.

The steam distillation method is a conventional manufacturing method for manufacturing essential oil, and by placing each part of a plant to be harvested on a grid and blowing steam from the bottom, the steam passes through the raw material and destroys the cell wall of the plant, so that the fragrance component is in the form of vapor. Is emitted as

At this time, the discharged steam passes through the cooling pipe and is separated into distillate and essential oil. The separated essential oil is collected above the distillate, and at this time, only the essential oil is separated and used.

In addition to the rose geranium essential oil, in order to increase the sleep-inducing effect, it may further include an extract of Juniperus rigida Siebold & Zucc.

The juniper is an evergreen arboreous tree growing at the foot of a sunny mountain, reaching a height of 8m, and the bark is vertically and shallowly split. The leaves are rotated by 3 and have ridges. Flowers hang on the axils of old branches around May. Fruits are spherical or oval, 7-8mm in diameter, and ripen in October of the following year.

The composition for preventing, improving or treating sleep disorders of the present invention may further include phenethyl alcohol, methyldihydrojasmonate, and linalul.

The phenethyl alcohol is an organic substance having a molecular structure of C ₆ H ₅ CH ₂ CH ₂ OH, and is found in various flowers such as rose, carnation, geranium, and has a rose scent.

The methyl dihydrojasmonate is an ester of methyl 3-oxo-2-pentylcyclopentane acetic acid and is found in natural products such as jasmine, tea, and heliotrope, and has a warm floral scent like jasmine.

Linalul is a chain-shaped monoterpene alcohol widely present in natural products such as bergamot oil, rosewood oil, and clary sage oil, and has a fresh floral scent.

The composition of the present invention is a mixture of rose geranium essential oil, juniper essential oil, phenethyl alcohol, methyldihydrojasmonate, and linalul, thereby inducing a psychological stability to the user, and has excellent sleep induction effect. .

Preferably, the composition is based on 100 parts by weight of rosegeranium essential oil, 10 to 15 parts by weight of juniper essential oil, 1 to 5 parts by weight of phenethyl alcohol, 1 to 5 parts by weight of methyldihydrojasmonate, and 1 to 5 parts by weight of linalul. It is characterized by including in parts by weight. When used within the above range, the effect of inducing a good night's sleep increases due to the synergistic effect of mixing and using each component.

The composition may further include a natural extract selected from the group consisting of Albizia julibrissin Durazz., Mimosa extract (Mimosa pudica L.), Hackberry extract (Celtis sinensis Pers.), and mixtures thereof.

The Albizia dulcis is a deciduous arboreous tree belonging to the legume family, and is a tree commonly found in streams or ridges in the south of Hwanghae-do, Korea. Large branches of 3 to 5m in height are sparsely spread, and small branches have ridges. The leaves are double pinnate compound leaves that are shifted. The small leaves are 6-15mm long and 2.5-4.0mm wide, bent like a sickle, and the left and right are not the same long oval, and the edges are flat. Flowers are light pink, bloom in June to July, and 15 to 20 flowers hang at the end of a small branch in an umbel shape. The flower looks pink because there are about 25 stamens protruding from the outside long, because of this color. The fruit ripens in September to October, is a flat pod, is about 15cm long, and contains 5 to 6 seeds.

The leaves of the Albizia julibrissin bloom in full bloom during the day, but at night, the leaves merge with each other and spend the night in a hug shape, which is called Haphwanmok or Yahapsu.

These days, it is also known as a love tree in Korean, and it has been known since ancient times because it is said that it gets better if you put a tree branch under the bed. In addition, the bark is called Haphwanpi, and it is usefully applied to medicines such as low back pain, bruises, blood stagnation, parasites, depression, and pungchi in private and oriental medicine. Eh, leaves were also sweetened and drunk as tea.

The mimosa is an annual plant native to Brazil and reaches 30cm in height. Leaves grow alternately, have petioles, and two pairs of right sides are spread out in a palm shape and split like feathers, and the lobules are linear and the edges are flat. The flowers are light red and hang roundly at the end of the peduncle from July to August. The fruit is a narrow fruit, with a node on the pod and contains 3 seeds.

The Hackberry is a deciduous arboreous tree that grows at the foot of the mountain or in the stream and reaches 20m in height, and fine hairs grow densely on young branches. Leaves are ovate or oblong, acute, acute, finely serrated, and rough. The flower is a miscellaneous flower and blooms in May. Fruits are drupe, round and ripe in October.

More preferably, the composition is based on 100 parts by weight of rose geranium essential oil, 10 to 15 parts by weight of juniper extract, 1 to 5 parts by weight of phenethyl alcohol, 1 to 5 parts by weight of methyldihydrojasmonate, 1 to 5 parts by weight of linalul It is characterized in that it contains 5 parts by weight, 1 to 3 parts by weight of Albizia vulgaris extract, 1 to 3 parts by weight of mimosa extract, and 1 to 3 parts by weight of Hackberry extract. When mixed in a small amount within the above range and used as a composite composition, the unique fragrance of Albizia julibrissin, mimosa extract, and Hackberry extract is not directly delivered, and is mixed with the fragrance of essential oil of rose geranium, allowing the user to use the fragrance of rose geranium. Psychological stability is improved, which can lead to better sleep induction.

Specifically, the extract can be prepared through the following method. Grinding the selected natural product; Leaching the pulverized product using an organic solvent; Drying the sample after leaching; Re-leaching the dried sample using an organic solvent; Drying the sample after leaching; Leaching with water; And including the step of leaching, it is possible to obtain a natural extract.

It may further include the step of performing fractionation using an organic solvent the natural extract extracted using the organic solvent.

The method of preparing the extract may be a conventional extraction method in the art, such as an ultrasonic extraction method, a leaching method, and a reflux extraction method. Specifically, it may be an extract obtained by extracting a natural product from which foreign matter is removed by washing and drying with water, alcohol having 1 to 6 carbon atoms, or a mixed solvent thereof, or an extract extracted by sequentially applying the solvents to a sample.

The reflux extraction method is based on 100 mL of an alcohol having 1 to 6 carbon atoms, based on a pulverized product of 10 to 30 g of a natural product, a reflux time of 1 to 3 hours, and an alcohol having 1 to 6 carbon atoms of 50 to 100%. More specifically, based on 100 mL of an alcohol having 1 to 6 carbon atoms, 10 to 20 g of a pulverized product of a natural product, a reflux time of 1 to 2 hours, and 70 to 90% of an alcohol having 1 to 4 carbon atoms are used.

The leaching method is by using an alcohol having 1 to 6 carbon atoms of 15 to 30°C for 24 to 72 hours and 50 to 100%. More specifically, 20 to 25° C., for 30 to 54 hours, and 70 to 80% of alcohol having 1 to 6 carbon atoms.

The ultrasonic extraction method is by 30 to 50 ℃, for 0.5 to 2.5 hours and 50 to 100% of the alcohol having 1 to 6 carbon atoms. Specifically, 40 to 50° C., for 1 to 2.5 hours, and 70 to 80% of alcohol having 1 to 6 carbon atoms.

The extraction solvent may be 2 to 50 times the weight of the sample, and more specifically 2 to 20 times. For extraction, the sample may be left for 1 to 72 hours for leaching in the extraction solvent, and more specifically, for 24 to 48 hours.

After extraction, the extract can be fractionated by sequentially applying a new fractionation solvent. The fractionation solvent used for fractionation is at least one selected from the group consisting of water, hexane, butanol, ethyl acetic acid, ethyl acetate, methylene chloride, and mixtures thereof, and preferably ethyl acetate or methylene chloride.

After obtaining the extract or fraction, a method such as concentration or lyophilization may be additionally used.

The fragrance composition for inducing a sound sleep according to another embodiment of the present invention may include rose geranium essential oil.

According to another embodiment of the present invention, the composition may be used as a composition for external application for skin. It can be used as a fragrance to induce a good night's sleep, as well as when used as an external application for the skin, the fragrance is directly delivered, so that the same effect as when used as a fragrance can be obtained.

The external preparation for skin is not limited to its formulation and can be used in any form known to those skilled in the art. The blending amount may be appropriately selected and used in order to achieve the desired effect according to conventional techniques in the art. Preferably, it may be included in an amount of 1 to 20% by weight based on the total weight, but is not limited to the above range.

The skin external formulation includes, for example, a pack, an ointment, a lotion, a solubilizing burn, a suspension, an emulsion, a cream, a gel, a spray, a gel patch, a warning agent, a patch, or a water paste.

According to the composition for preventing, improving or treating sleep disorders comprising rose geranium essential oil of the present invention, it is used as aromatherapy, and has excellent sleep induction effect for polysomnography.

In addition, it is possible to provide a perfume composition and a composition for external application for skin including a composition for preventing, improving or treating sleep disorders including rose geranium essential oil.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

[Production Example: Preparation of a composition for inducing sleep]

1. Manufacture of rose geranium essential oil (PO)

Place the leaves and stems of rose geranium on the grid and blow steam from the bottom. At this time, the discharged steam passes through the cooling pipe, so that the distillate and the rose geranium essential oil are separated. The separated essential oil was collected above the distillate, and at this time, only the essential oil was separated to prepare a rose geranium essential oil.

2. Preparation of natural extract

The leaves, stems and roots of the juniper were washed, dried, and then crushed. The pulverized product was mixed with water and maintained at 98 to 100° C. for 2 hours, cooled and filtered through Whatman filter paper to obtain the filtrate (JE).

Natural extracts were prepared using the same method as that of the juniper tree extract (JE) in the case of Albizia julibrissin (AE), mimosa (ME) and Hackberry (CE).

3. Preparation of composition for inducing sleep

The rose geranium essential oil (PO), juniper extract (JE), albizia julibrissin extract (AE), mimosa extract (ME), hackberry extract (CE), phenelty alcohol (PA), methyldihydrojasmonate (MD) , Linalol (RL), ethanol (EO), purified water (WT), and polyoxyethylene cetyl ether (Emalex 107) were mixed within the following composition range to prepare a composition for inducing sleep.

WP1 WP2 WP3 WP4 WP5 PO 100 100 100 100 100 JE 5 10 13 15 20 AE 0.5 One 2 3 4 ME 0.5 One 2 3 4 CE 0.5 One 2 3 4 PA 5 5 5 5 5 MD 5 5 5 5 5 RL 5 5 5 5 5 EO 300 300 300 300 300 WT 500 500 500 500 500 Emlex 107 5 5 5 5 5

(Unit weight part)

[Experimental Example 1: Sensory evaluation]

Five men and women who thought they were sensitive to scent were selected, and sensory evaluation of scent was conducted. Sensory evaluation provided a perfume composition for the above WP1 to WP5 and requested a relative evaluation for each fragrance.

The score was 1 to 5, and the evaluation was requested, and the higher the score, the better the evaluation was.

[Evaluation Table]

1. I feel refreshed.

2. I feel warmed.

3. I feel calm and calm.

4. I feel excited.

5. It is a fragrance with high preference.

WP1 WP2 WP3 WP4 WP5 number 1 One 3 4 4 2 No.2 One 3 4 4 One number 3 One 3 5 4 2 Number 4 One 2 One One 2 Number 5 One 3 5 4 One

According to the sensory evaluation, it was confirmed that excellent evaluation was shown in WP2 to 4, and in particular, WP3 received the most excellent evaluation.

[Experimental Example 2: Sensory evaluation]

In order to objectively evaluate the sleep effect of the perfume composition against WP1 to WP5, a sleep polymorphism test and evaluation of sleep were performed on 10 adult men and women.

The subjects of the study were 10 men and women in their 20s to 30s who are healthy, do not currently take drugs, and are not intoxicated. The experimenter was asked to refrain from excessive exercise or excessive alcohol consumption on the day before the experiment, and on the day of the experiment he was to refrain from ingesting smoking, drinks, drugs, and gum that may affect the central nervous system and sense of smell. In the case of adult females, it was reported that there was a correlation between the change in the sense of scent according to the female sex cycle and the female menstrual cycle and mood, so this was conducted in consideration of the menstrual cycle of the subjects.

As a comparative example, the same test was carried out under an unscented condition (Comparative Example 1). Sleep testing was conducted in a sleep laboratory with constant scent.

The sleep polymorphism test was conducted in a sleep laboratory, and a soundproofing device was installed to remove sleep disturbance factors caused by external factors.

The polysomnography test was conducted under the conditions of the comparative example and the fragrance composition of the present invention. In order to exclude the order effect on sleep, the type of sample was randomly performed for each subject, and before this experiment was conducted, two sleep laboratories were allowed to sleep in order to adapt to the sleep laboratory. Sleep time was taken for 2 hours during the week, and each subject was allowed to sleep at the same time. In addition, the subjective evaluation of sleep after sleep was collected through a questionnaire.

Measurement of Elevation Delay Time

The elevation delay time was the time from entering the bed to falling asleep, and the difference in the time (minutes) from entering the bed to sleep was evaluated.

Comparative example WP1 WP2 WP3 WP4 WP5 Elevation average delay time 40.50 38.50 34.50 28.55 31.50 39.50

(Unit minutes and average values were measured.)

As shown in Table 3, it was confirmed that, on average, under the fragrance-free condition, it took a lot of time to enter the sleep.

In view of the above experimental results, it was confirmed that the effect of inducing a sound sleep was excellent when using the perfume composition of the present invention.

Sleep efficiency

Sleep efficiency is the ratio of total sleep time to the time in bed, and the ratio of sleep time during the experiment was compared.

Comparative example WP1 WP2 WP3 WP4 WP5 Sleep efficiency 60.0 60.5 62.5 64.5 61.0 60.5

(Unit %) According to the above experimental results, it was confirmed that the excellent sleep efficiency was exhibited under the conditions of WP2 to 4 compared to the unscented condition.

Sleep satisfaction evaluation

For the test subjects, sleep satisfaction was evaluated. Evaluation was requested with 1 to 5 points, and evaluation was performed with an average.

Comparative example WP1 WP2 WP3 WP4 WP5 Sleep satisfaction 2 2 4 5 4 3

According to the above evaluation results, it was confirmed that superior evaluation was exhibited in WP2 to 4 compared to the comparative example. In particular, it was confirmed that it exhibits a better evaluation than when configuring the perfume composition within the scope of the present invention.

Example formulation

In the following content range, a gel was prepared.

2.0% by weight of the fragrance composition of WP3,

15% by weight of polyvinyl alcohol

0.1% by weight of sodium carboxymethylcellulose

7% by weight of glycerin

0.1% by weight allantoin

Ethanol 5% by weight

PEG 12 nonylphenyl ether 0.3% by weight

Polysorbate 60 0.3% by weight

0.5% by weight of preservative

Remaining purified water

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention defined in the following claims are also present. It belongs to the scope of rights of

Claims (7)

Contains essential oils of pelargonium graveolens,
Juniperus rigida Siebold & Zucc. extract, Albizia julibrissin Durazz. extract, Mimosa pudica L. extract, Celtis sinensis Pers. extract, phenelty alcohol, methyldihydrojasmonate , Linalol, ethanol, purified water and polyoxyethylene cetyl ether,
Excellent prevention, improvement or treatment of sleep disorders through sleep induction
A composition for inducing sleep containing rose geranium essential oil. The method of claim 1,
The rose geranium essential oil is used as aromatherapy, and has excellent sleep induction effect for polysomnography.
A composition for inducing sleep containing rose geranium essential oil. The method of claim 1,
The sleep disorders are: sleep disorders, sleep disorders, severe arousal, early arousal, insomnia, nightmares, sleepwalking, narcolepsy, abnormal behavior during sleep, hypersomnia, sleep seizures, respiratory-related sleep disorders, apnea, circadian rhythm sleep Disorders (circadian rhythm sleep disorders), parasomnia, restless legs syndrome, and periodic limb movement disorders.
A composition for inducing sleep containing rose geranium essential oil. delete delete Comprising the composition according to claim 1
Fragrance composition. Comprising the composition according to claim 1
Composition for external application for skin.