KR102184978B1 - Manufacturing method of contact lens - Google Patents

Abstract

The present invention relates to a method for manufacturing a contact lens, and polymerization is performed by including 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), a hydrophilic monomer, and the method for manufacturing a contact lens comprises a color coating. By using a corrosion plate,
Therefore, the contact lens manufacturing method of the present invention supplements the moisture content and wettability by adding PEGMEMA to HEMA, which is a basic contact lens material, supplements the UV blocking function by adding 2,4-dihydroxybenzophenone, and adds ITO nanoparticles. By complementing the electromagnetic wave blocking function, it is possible to manufacture a high-functional contact lens with high wettability, high water content, UV blocking, and electromagnetic wave shielding functions, and by using PEGMEMA, 2,4-dihydroxybenzophenone and ITO nanoparticles, smartphones and electronic devices As the use of the material increases, it has a remarkable effect, such as that it can be used in various other fields as a material that can supplement the necessary physical properties.
In addition, the present invention has a remarkable effect in that the corrosion plate made of ceramic is used during manufacturing, so that the quality is excellent, there is no defect on the surface, and a delicate color shape is implemented.

Description

Contact lens manufacturing method {Manufacturing method of contact lens}

The present invention relates to a contact lens manufacturing method, and more particularly, to HEMA (2-hydroxyethyl methacrylate), which is a basic contact lens material, AIBN (azobis iso butyronitrile) as an initiator, PVP (polyvinylpyrrolidone) as an irritation-lowering agent, and EGDMA as a crosslinking agent. (ethylene glycol dimethacrylate), hydrophilic monomer PEGMEMA [poly(ethylene glycol) methyl ether methacrylate], UV blocking agent 2,4-dihydroxybenzophenone, and electromagnetic wave shielding agent ITO (Indium Tin Oxide) It relates to a method of manufacturing a contact lens having functions such as moisture content, UV protection, and electromagnetic shielding.

With the recent development of electronic technology for convenience, it is true that the user's convenience has increased as the number of devices that use electromagnetic waves in everyday life such as computers, TVs, radios, and mobile phones increase, but adverse functions caused by continuous exposure to electromagnetic waves cannot be ignored. . In addition, according to the results of several studies, it was analyzed that most of the ordinary people spend more than 90% of the day indoors.

As the use of electromagnetic waves increases rapidly, interest in the harmfulness of electromagnetic waves through electronic devices used in daily life of modern people is increasing rapidly.

In particular, concerns about the indoor environment, which have a direct impact on daily life, are rising.

As an electromagnetic wave shielding material, many metal materials having excellent electrical conductivity are used.

Recently, research on light-transmitting materials such as protective films for electronic devices such as mobile phones, PCs, and contact lenses is being conducted.

According to the research of Kim et al., a study on the possibility of using an ITO thin film as a translucent shielding agent by using ITO (Indium Tin Oxide) having high electrical conductivity has been reported.

In addition, PEG [Poly(ethylene glycol)] is widely known as a representative hydrophilic monomer, and is a material with excellent biocompatibility, and is widely used as a material to modify the surface by making the surface of a drug delivery and hydrophobic material hydrophilic. When dihydroxybenzophenone is used in medical lenses, cosmetics, bottles, and films, it is known to have excellent UV protection.

Light is a kind of electromagnetic wave and includes visible light (380nm to 780nm), ultraviolet (380nm or less) and infrared (700nm or more), and is referred to as X-ray or gamma ray.

Visible light is light from purple (about 380 nm) to red (about 700 nm), which means the wavelength range in which humans can see objects. Especially, blue light is a violet type of visible light that has high refractive power and dispersibility. Chromatic aberration is generated in and focus is focused in front of the retina, so the image sharpness is relatively reduced, causing eye fatigue.

Specifically, when light is absorbed by the photoreceptor cells of the eye, the cells become insensitive until recovery, and this recovery process corresponds to a metabolic process.

Absorption of the blue light has been shown to prematurely reverse the recovery process, and this early reversal has been studied to increase the risk of damage and to cause accumulation of the pigment lipofuscin in the retina.

In particular, the accumulation of lipofuscin occurs in the retinal pigment epithelium (RPE) layer, and extracellular substance drusen is aggregated in the RPE layer due to an excessive amount of lipofuscin, and the drusen is the RPE layer. It is known to cause damage or death of these cells by interfering with or blocking the supply of nutrients to the receptor.

In addition, since blue light has a high energy and high transmittance, there is a problem in that it increases eye fatigue because it strongly stimulates the optic nerve.

On the other hand, in order to solve the blocking of ultraviolet or blue light, according to the prior art, as described in Registration No. 10-1190303, in a colored contact lens having an iris-shaped colored part, an iris design having a desired shape is provided on the corrosion plate. Eroding; Printing a composition for forming a colored part including a color powder, 2-HEMA, a polymerization initiator, and a crosslinking agent on the corrosion plate on which the design is formed; Attaching the printed composition for forming a colored part to a silicone pad; Printing a silicone pad on the upper mold to transfer the design composed of the composition for forming the colored part to the mold; Forming a spherical colored portion by polymerizing the composition by irradiating UV for 25 to 60 minutes until the polymerization rate of the composition for forming the colored portion is 90 to 95%; And forming a contact lens in which the spherical colored portion is embedded by applying a lens-forming polymer to the hammold, and then inserting the upper mold with the colored portion formed therein to polymerize the lens-forming polymer. And, the composition for forming the colored part is color powder 10 to 20% by weight, 2-HEMA 16 to 70.5% by weight, methacrylic acid 3 to 5% by weight, glycidyl methacrylate 5 to 20% by weight, polymerization initiator 1 To 5% by weight and 10 to 30% by weight of titanium dioxide, and 0.5 to 4% by weight of trimethylolpropanetrimethacrylate as a crosslinking agent, the colored contact lens incorporated into the lens The manufacturing method of is registered and disclosed.

In addition, a first step of forming a first thin film by applying a composition for forming a lens to a lower mold according to Patent Publication No. 10-2016-0129305; A second step of attaching the blue light blocking thin film to the upper mold; A third step of bonding the blue light blocking thin film to the first thin film; A fourth step of applying the lens-forming composition to an upper mold; And a fifth step of laminating the lower mold to which the first thin film is attached to the upper mold of the fourth step and polymerizing the composition for forming a lens to form a second thin film, wherein the blue light blocking part is inserted into the lens. A method of manufacturing a lens is described.

However, in the conventional contact lens as described above, the color part is applied to the streamlined mold, and the colored part is not uniformly formed due to the phenomenon that the color part is clustered on the edge of the jig, or the blue light blocking part is embedded in the lens, so the manufacturing process is complicated. It takes a lot of manufacturing time and has problems such as high manufacturing cost due to high defect rate of the product.

Therefore, through the contact lens manufacturing method of the present invention, PEGMEMA is added to HEMA, which is a basic contact lens material, to supplement moisture content and wettability, and 2,4-dihydroxybenzophenone is added to supplement the UV blocking function, and ITO nanoparticles ) To provide a contact lens that complements the electromagnetic wave blocking function.

In addition, it is intended to provide a method of using a ceramic corrosion plate for the color coating.

The present invention relates to a method for manufacturing a contact lens, and is characterized in that polymerization is performed by including 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), which is a hydrophilic monomer.

In addition, it is characterized in that it further comprises AIBN (azobis iso butyronitrile) as an initiator during the polymerization, PVP (polyvinylpyrrolidone) as an irritation-lowering agent, and EGDMA (ethylene glycol dimethacrylate) as a crosslinking agent.

In addition, it is characterized by polymerization by adding 2,4-dihydroxybenzophenone with UV blocking function.

In addition, it is characterized in that the polymerization by adding ITO (Indium Tin Oxide) nanoparticles having an electromagnetic wave blocking function.

In addition, the contact lens manufacturing method is characterized by using a ceramic corrosion plate for color coating. ITO is included in color coating to improve electromagnetic wave shielding ability. In this case, if a corrosion plate made of ceramic is used, the pigment/dye containing ITO nanoparticles is uniformly colored on the color contact lens.

In the method of manufacturing a contact lens of the present invention, PEGMEMA, which is a basic contact lens material, is added to supplement moisture content and wettability, 2,4-dihydroxybenzophenone is added to complement the UV blocking function, and ITO nanoparticles are added to provide electromagnetic waves. By supplementing the blocking function, it is possible to manufacture a high-functional contact lens with high wettability, high water content, UV blocking, and electromagnetic wave shielding functions, and using PEGMEMA, 2,4-dihydroxybenzophenone, and ITO nanoparticles, As the use increases, it has a remarkable effect, such as that it can be used in various other fields as a material that can supplement the required physical properties.

In addition, the present invention uses a ceramic corrosion plate during manufacture, which is excellent in quality, and in particular, there is no defect on the surface as ITO nanoparticles are uniformly applied, and there is a remarkable effect of implementing a delicate color shape.

1 is a surface analysis of macromolecules by AFM (atomic force microscope) image
2 is a SEM (scanning electron microscope) image of a contact lens sample prepared by adding HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB, ITO nanoparticles
3 is a graph showing the moisture content and refractive index of contact lenses (Ref. sample) made of HEMA, PVP, EGDMA, and AIBN and contact lenses manufactured by adding 1 to 20% by weight PEGMEMA to HEMA, PVP, EGDMA, and AIBN
Figure 4 shows the contact angle measurement results of a contact lens (Ref. sample) made of HEMA, PVP, EGDMA, AIBN and a contact lens (PEG20 sample) manufactured by adding 20% by weight PEGMEMA to HEMA, PVP, EGDMA, and AIBN Picture
Figure 5 is prepared by adding 0.1 to 1.0% by weight DP (2,4-dihydroxybenzophenone) to Ref.-P and HEMA, PVP, EGDMA, AIBN, PEGMEMA, contact lenses made of HEMA, PVP, EGDMA, AIBN, PEGMEMA Light transmittance measurement graph of contact lenses
Figure 6 is a contact lens manufactured by adding HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB contact lenses with Ref.-D and HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB, 0.1% by weight ITO nanoparticles Electromagnetic shielding graph of phosphorus ITO 0.1

The present invention relates to a method for manufacturing a contact lens, and is characterized in that polymerization is performed by including 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), which is a hydrophilic monomer.

In addition, it is characterized in that it further comprises AIBN (azobis iso butyronitrile) as an initiator during the polymerization, PVP (polyvinylpyrrolidone) as an irritation-lowering agent, and EGDMA (ethylene glycol dimethacrylate) as a crosslinking agent.

In addition, it is characterized by polymerization by adding 2,4-dihydroxybenzophenone with UV blocking function.

In addition, it is characterized in that the polymerization by adding ITO (Indium Tin Oxide) nanoparticles having an electromagnetic wave blocking function.

In addition, the contact lens manufacturing method is characterized in that a corrosion plate is used for color coating.

The present invention will be described in detail with reference to the accompanying drawings.

1 is a surface analysis of macromolecules by AFM (atomic force microscope) image, and FIG. 2 is a SEM (scanning electron) of a contact lens sample prepared by adding HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB, ITO nanoparticles. Microscope) image, Figure 3 is a contact lens (Ref. sample) made of HEMA, PVP, EGDMA, AIBN and 1-20% by weight PEGMEMA added to HEMA, PVP, EGDMA, AIBN moisture content and refractive index of the contact lenses manufactured 4 is a contact angle of a contact lens (Ref. sample) made of HEMA, PVP, EGDMA, and AIBN and a contact lens (PEG20 sample) manufactured by adding 20% by weight PEGMEMA to HEMA, PVP, EGDMA, and AIBN Photo showing the measurement results, Figure 5 is a contact lens made of HEMA, PVP, EGDMA, AIBN, PEGMEMA Ref.-P and HEMA, PVP, EGDMA, AIBN, PEGMEMA 0.1 to 1.0% by weight DP (2,4- dihydroxybenzophenone) was added to measure the light transmittance of contact lenses, FIG. 6 is a contact lens made of HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB contact lenses, Ref.-D and HEMA, PVP, EGDMA, AIBN, PEGMEMA, It is an electromagnetic wave shielding graph of ITO 0.1, a contact lens manufactured by adding DB and 0.1% by weight of ITO nanoparticles.

In the present invention, a contact lens was manufactured by polymerization by adding 2-hydroxyethyl methacrylate (HEMA), AIBN, polyvinylpyrrolidone (PVP), ethylene glycol dimethacrylate (EGDMA), and poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), a hydrophilic monomer.

The HEMA (2-hydroxyethyl methacrylate) used in the present invention and the AIBN used as the initiator were manufactured by JUNSEI, and were made of PVP (polyvinylpyrrolidone), PEGMEMA (poly(ethylene glycol) methyl ether methacrylate), and the crosslinking agent EGDMA (ethylene glycol). dimethacrylate) was used by Sigma-Aldrich.

A contact lens made of HEMA, AIBN, PVP, EGDMA was named Ref., and PEGMEMA 1, 5, 10, 15, 20% by weight was added to HEMA, AIBN, PVP, and EGDMA, respectively, and polymerized to be 100% by weight. , Each contact lens sample used in the experiment was named PEG1, PEG5, PEG10, PEG15, and PEG20, respectively, according to the addition ratio.

(Unit: weight%) Sample HEMA PVP EGDMA AIBN PEG Total Ref. 96.44 2.89 0.48 0.19 0.00 100.00 PEG1 95.47 2.86 0.48 0.19 1.00 100.00 PEG5 91.60 2.76 0.46 0.18 5.00 100.00 PEG10 86.75 2.63 0.44 0.18 10.00 100.00 PEG15 81.89 2.52 0.42 0.17 15.00 100.00 PEG20 77.03 2.41 0.40 0.16 20.00 100.00

Mixing ratio of contact lens samples polymerized by adding 0, 0.10, 5.00, 10.00, 15.00, 20.00% by weight of PEGMEMA to HEMA, PVP, EGDMA, and AIBN for each sample

As shown in Table 1, samples used for the polymerized contact lenses of the present invention are HEMA (2-hydroxyethyl methacrylate) 77.03 to 96.03 wt%, PVP (polyvinylpyrrolidone) 2.41 to 2.86 wt%, EGDMA (ethylene glycol dimethacrylate) 0.40 to 0.48% by weight, 0.16 to 0.19% by weight of AIBN, and 1.00 to 20.00% by weight of PEGMEMA (poly(ethylene glycol) methyl ether methacrylate) were mixed.

If the HEMA is added in an amount of less than 77.03% by weight, the strength of the contact lens is weakened, and it is difficult to maintain the shape of the polymerized contact lens.If it is added in excess of 96.03% by weight, the flexibility of the contact lens decreases, making the contact lens uncomfortable when wearing the contact lens.

When the PVP is added in an amount of less than 2.41% by weight, the eyes are uncomfortable when wearing a contact lens, and when it is added in excess of 2.86% by weight, an unreacted material may remain in the contact lens.

When the EGDMA is added in an amount of less than 0.40% by weight, the contact lens polymer mixture is not well formed, and when it is added in an amount exceeding 0.48% by weight, an unreacted material may remain in the contact lens.

When the AIBN is added in an amount of less than 0.16% by weight, it takes a long time to form a contact lens polymer mixture, and when it is added in an amount exceeding 0.19% by weight, an unreacted material may remain in the contact lens.

If the PEGMEMA is added in less than 1.00% by weight, the moisture content of the contact lens decreases, making the eyes uncomfortable when wearing the contact lens, and if it is added in excess of 20.00% by weight, the strength of the contact lens is weakened, making it difficult for the polymerized contact lens to maintain its shape. .

In addition, as a second embodiment of manufacturing a contact lens of the present invention, the present invention is HEMA (2-hydroxyethyl methacrylate), hydrophilic monomer PEGMEMA (poly(ethylene glycol) methyl ether methacrylate), initiator AIBN (azobis iso butyronitrile), stimulation reduction A contact lens was prepared by polymerization by adding zero PVP (polyvinylpyrrolidone), EGDMA (ethylene glycol dimethacrylate) as a crosslinking agent, and 2,4-dihydroxybenzophenone with UV blocking function.

Contact lenses made of HEMA, AIBN, PVP, EGDMA, and PEGMEMA were named Ref-P., and 0.10, 0.30, 0.50, 0.70, and 1.00% by weight of DB were added to HEMA, AIBN, PVP, EGDMA, and PEGMEMA, respectively. It was polymerized to be 100% by weight, and each contact lens sample used in the experiment was named DB0.1, DB0.3, DB0.5, DB0.7, and DB1.0, respectively, according to the addition ratio.

(Unit: weight%) Sample HEMA PVP EGDMA AIBN PEG DB Total Ref.-P 87.67 2.62 0.44 0.17 9.10 0.00 100.00 DB0.1 87.59 2.62 0.44 0.17 9.08 0.10 100.00 DB0.3 87.41 2.62 0.44 0.17 9.06 0.30 100.00 DB0.5 87.23 2.62 0.44 0.17 9.04 0.50 100.00 DB0.7 87.05 2.62 0.44 0.17 9.02 0.70 100.00 DB1.0 86.77 2.62 0.44 0.17 9.00 1.00 100.00

As shown in Table 2, the samples used for the polymerized contact lenses of the present invention according to the second embodiment were 86.77 to 87.67 wt% of 2-hydroxyethyl methacrylate (HEMA), 2.62 wt% of polyvinylpyrrolidone (PVP), and 0.44 ethylene glycol dimethacrylate (EGDMA). Weight%, AIBN 0.17% by weight, PEGMEMA (poly(ethylene glycol) methyl ether methacrylate) 9.00 to 9.08% by weight, and DB (2,4-dihydroxybenzophenone) 0.10 to 1.00% by weight were used.

When the HEMA is added in an amount of less than 86.77% by weight, the strength of the contact lens is weakened and it is difficult to maintain the shape of the polymerized contact lens, and when it is added in excess of 87.67% by weight, the flexibility of the contact lens decreases, making the contact lens uncomfortable when wearing the contact lens.

When the PVP is added in an amount of less than 2.62% by weight, the eyes are uncomfortable when wearing a contact lens, and when it is added in excess of 2.62% by weight, an unreacted material may remain in the contact lens.

When the EGDMA is added in an amount of less than 0.44% by weight, the contact lens polymer mixture is not well formed, and when it is added in an amount exceeding 0.44% by weight, an unreacted material may remain in the contact lens.

When the amount of AIBN is added in an amount of less than 0.17% by weight, it takes a long time to form a contact lens polymer mixture, and when it is added in an amount exceeding 0.17% by weight, an unreacted material may remain in the contact lens.

If the PEGMEMA is added in less than 9.00% by weight, the moisture content of the contact lens decreases, making the eyes uncomfortable when wearing the contact lens, and if it is added in excess of 9.08% by weight, the strength of the contact lens decreases, making it difficult for the polymerized contact lens to maintain its shape. .

When the DB is added in an amount of less than 0.10% by weight, the UV blocking function of the contact lens decreases, and when it is added in an amount exceeding 1.00% by weight, the transparency of the contact lens tends to decrease.

In addition, as a method for manufacturing a contact lens according to the third embodiment, the present invention includes 2-hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), which is a hydrophilic monomer, and AIBN (azobis iso butyronitrile) as an initiator, PVP (polyvinylpyrrolidone) as an irritation-lowering agent, EGDMA (ethylene glycol dimethacrylate) as a crosslinking agent, 2,4-dihydroxybenzophenone with UV blocking function, and ITO nanoparticles with electromagnetic wave blocking function were additionally added and polymerized to prepare a contact lens.

The method of manufacturing a contact lens by adding ITO nanoparticles having an electromagnetic wave blocking function is shown in Tables 3 and 4 below by performing two experiments with largely different DB compositions.

In Tables 3 and 4, the contact lens manufactured by including HEMA, AIBN, PVP, EGDMA, PEGMEMA, and DB was named Ref.-D, and in the third run, HEMA, AIBN, PVP, EGDMA, PEGMEMA, and ITO nanoparticles in DB Each contact lens sample used in the experiment was named ITO 0.05 and ITO 0.1, respectively, according to the addition ratio after polymerization by adding 0.05 and 0.10% by weight respectively.

(Unit: weight%) Sample HEMA PVP EGDMA AIBN PEG DB ITO Total Ref.-D 87.24 2.61 0.44 0.17 9.04 0.50 0.00 100.00 ITO0.05 87.19 2.61 0.44 0.17 9.04 0.50 0.05 100.00 ITO0.1 87.14 2.61 0.44 0.17 9.04 0.50 0.10 100.00

Mixing ratio for each sample of contact lens samples polymerized by adding 0, 0.05, 0.10% of ITO nanoparticles to HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB

(Unit: weight%) Sample HEMA PVP EGDMA AIBN PEG DB ITO Total Ref.-D 84.74 2.61 0.44 0.17 9.04 3.00 0.00 100.00 ITO0.05 84.69 2.61 0.44 0.17 9.04 3.00 0.05 100.00 ITO0.1 84.64 2.61 0.44 0.17 9.04 3.00 0.10 100.00

Mixing ratio for each sample of contact lens samples polymerized by adding 0, 0.05, 0.10% of ITO nanoparticles to HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB

As described in Table 3 and Table 4, the polymerization for the manufacture of a contact lens according to the third implementation was HEMA 84.64 to 87.19 wt%, PVP 2.61 wt%, EGDMA 0.44 wt%, AIBN 0.17 wt% PEGMEMA 9.04 wt%, DB A contact lens was copolymerized by adding 0.05 to 0.10% by weight of ITO nanoparticles having an electromagnetic wave blocking function to 0.5 to 3.00% by weight.

When the HEMA is added in an amount of less than 84.64% by weight, the strength of the contact lens is weakened, and it is difficult to maintain the shape of the polymerized contact lens.If it is added in excess of 87.19% by weight, the flexibility of the contact lens decreases, making the contact lens uncomfortable when wearing the contact lens.

When the PVP is added in an amount of less than 2.61% by weight, the eyes are uncomfortable when wearing a contact lens, and when it is added in excess of 2.61% by weight, an unreacted material may remain in the contact lens.

When the EGDMA is added in an amount of less than 0.44% by weight, the contact lens polymer mixture is not well formed, and when it is added in an amount exceeding 0.44% by weight, an unreacted material may remain in the contact lens.

When the amount of AIBN is added in an amount of less than 0.17% by weight, it takes a long time to form a contact lens polymer mixture, and when it is added in an amount exceeding 0.17% by weight, an unreacted material may remain in the contact lens.

If the PEGMEMA is added in less than 9.04% by weight, the moisture content of the contact lens decreases, making the eyes uncomfortable when wearing the contact lens, and if it is added in excess of 9.04% by weight, the strength of the contact lens decreases, making it difficult for the polymerized contact lens to maintain its shape. .

When the DB is added in an amount of less than 0.50% by weight, the UV blocking function of the contact lens decreases, and when it is added in an amount exceeding 3.00% by weight, the transparency of the contact lens tends to decrease.

When the ITO nanoparticles are added in an amount of less than 0.05% by weight, the electromagnetic wave blocking function of the contact lens is deteriorated, and when it is added in an amount exceeding 0.10% by weight, the transparency of the contact lens tends to decrease.

In addition, ITO nanoparticles can be added by being buried on the pad.

Meanwhile, the moisture content of the contact lenses manufactured by the method of the above examples was measured using the Gravimetric method.

Five contact lens samples manufactured under the same conditions were measured, and the average value of the values converted into percentages was calculated and shown.

The refractive index was measured by calculating the average value measured five times based on ISO 18369-4:2006 (Ophthalmic optics-Contact lenses-Part 4: Physicochemical properties of contact lens materials, 4.5. Refractive index).

The spectral transmittance was measured by dividing the near-ultraviolet region of about 280 nm to 380 nm and the visible ray region, measuring the transmittance of the near-ultraviolet region and the visible ray region five times, respectively, and calculating the average of the values expressed as percentages.

The transmittance of all regions is expressed as a percentage.

In particular, for the analysis of the surface of the contact lens containing ITO nanoparticles, the analysis was performed using Park Systems' XE-100, AFM (Atomic force microscope).

The average moisture content of Ref., a contact lens made of HEMA, PVP, EGDMA, and AIBN, is 39.90%, and the average moisture content of contact lenses manufactured by adding PEGMEMA to HEMA, PVP, EGDMA, and AIBN is 40.96 according to the addition ratio of PEGMEMA. % ~ 53.59%, and the moisture content tended to increase compared to Ref.

The average value of the refractive index is Ref. The refractive index of 1.4248 and PEG1 to 20 were 1.4240 to 1.4018, and the refractive index decreased according to the amount of PEGMEMA added, indicating a tendency when a hydrophilic monomer was added to a general hydrogel contact lens.

The moisture content and refractive index graphs of a plurality of contact lenses manufactured by adding PEGMEMA to HEMA, PVP, EGDMA, and AIBN are summarized and shown in FIG. 3.

In addition, the contact angle measurement results of a contact lens (Ref. sample) made of HEMA, PVP, EGDMA, AIBN and a contact lens (PEG20 sample) manufactured by adding 20% by weight of PEGMEMA to HEMA, PVP, EGDMA, and AIBN are shown in FIG. 4 Shown in.

As a result, when a contact lens is manufactured by adding PEGMEMA to HEMA, PVP, EGDMA, and AIBN, it can be used as a material for contact lenses having high moisture content and high wettability.

In addition, when PEGMEMA is added to HEMA, PVP, EGDMA, and AIBN to supplement high water content and high wettability, and add 2,4-dihydroxybenzophenone, a commonly known sunscreen, to add sunscreen functionality,

Ref.-P, a contact lens made of HEMA, PVP, EGDMA, AIBN, and PEGMEMA, has an average moisture content of 47.87% and an average refractive index of 1.4135, and UV rays for the HEMA, PVP, EGDMA, AIBN, and PEGMEMA The average moisture content of the contact lenses prepared by adding the blocking agent DB (2,4-dihydroxybenzophenone) was measured to be 47.64 ~ 47.86% depending on the addition ratio of 2,4-dihydroxybenzophenone, and the average value of the refractive index was 1.4136 ~ 1.4158, 2,4 The refractive index did not change significantly depending on the amount of -dihydroxybenzophenone added.

The average transmittance values in the near ultraviolet region ranged from 74.61% for the Ref.-P sample and 17.23 to 1.93% for DB0.1 to 1.0, respectively.

In the case of Ref.-P, the visible light area is 90.94%, and in the case of DB0.1~1.0, the visible light area is in the range of 87.01 ~ 83.04%, blocking the ultraviolet area, and blocking up to about 400 nm of the visible light area is blue. It was found that the average value of the visible light region decreased according to the addition ratio of 2,4-dihydroxybenzophenone by partially blocking the light region.

Table 5 shows the photophysical properties of the combination in which 2,4-dihydroxybenzophenone was added to Ref.-P.

Sample Refractive Index near-UV Vis. Water Content(%) Ref.-P 1.4135 74.61 90.94 47.87 DB0.1 1.4136 17.23 87.01 47.80 DB0.3 1.4140 8.12 85.42 47.64 DB0.5 1.4154 4.54 84.21 47.82 DB0.7 1.4153 3.38 85.75 47.84 DB1.0 1.4158 1.93 83.04 47.86

Manufactured by adding 0.1 to 1.0% DP (2,4-dihydroxybenzophenone) as a sunscreen to Ref.-P, a contact lens made of HEMA, PVP, EGDMA, AIBN, and PEGMEMA, and HEMA, PVP, EGDMA, AIBN, and PEGMEMA. Optical physical properties of contact lens sample groups

In addition, 0.1 to 1.0% DB (2,4-dihydroxybenzophenone) as a sunscreen was added to Ref.-P, a contact lens made of HEMA, PVP, EGDMA, AIBN, and PEGMEMA, and HEMA, PVP, EGDMA, AIBN, and PEGMEMA. Fig. 5 shows a graph for measuring light transmittance of the prepared contact lens sample group.

Therefore, in the case of a contact lens manufactured by adding DB (2,4-dihydroxybenzophenone) to HEMA, PVP, EGDMA, AIBN, and PEGMEMA, it can be used as a material for contact lenses having high moisture content and high wettability, and has UV blocking functionality.

And if ITO nanoparticles with electromagnetic shielding function are added to add electromagnetic wave blocking functionality to HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB (2,4-dihydroxybenzophenone),

Ref.-D, a contact lens made of HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB (2,4-dihydroxybenzophenone), had an average moisture content of 47.82% and an average refractive index of 1.4154, and

The average moisture content of the contact lenses prepared by adding ITO nanoparticles to HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB (2,4-dihydroxybenzophenone) is ITO0.05 47.72%, depending on the addition ratio of ITO nanoparticles, and ITO0 .1 was measured as 47.12%, and the average value of the refractive index was 1.4153 when ITO0.05, and 1.4181 when ITO0.1. The moisture content decreased slightly according to the amount of ITO nanoparticles added, and the refractive index tended to increase slightly. appear.

Electromagnetic wave measurement results of the manufactured contact lenses, compared to Ref.-D made of HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB, ITO nano in HEMA, PVP, EGDMA, AIBN, PEGMEMA, DB (2,4-dihydroxybenzophenone) The electromagnetic wave shielding effect was high in the ITO1.0 sample to which 1.0% by weight of particles was added.

In addition, the electromagnetic wave shielding graph of the group in which ITO nanoparticles were added to Ref.-D is shown in FIG. 6.

Finally, PEGMEMA and ITO nanoparticles are added to the basic HEMA contact lens material, which is highly valuable as a contact lens material with high moisture content, high wettability, UV blocking function and electromagnetic wave blocking function.

In the present invention, the physical properties that are insufficient in steps of the basic HEMA contact lens material are supplemented.

Accordingly, the present invention supplemented the moisture content and wettability by adding PEGMEMA to HEMA, PVP, EGDMA, and AIBN, and supplemented the UV blocking function by adding DB (2,4-dihydroxybenzophenone) by ratio,

To complement the electromagnetic wave blocking function, ITO nanoparticles were added to add electromagnetic wave shielding function, and finally, a contact lens material with high wettability, high water content, UV protection, and electromagnetic wave shielding functions was developed.

The material of the contact lens of the present invention is a basic contact lens material, HEMA, PEGMEMA, DB (2,4-dihydroxybenzophenone), and ITO nanoparticles to supplement the physical properties required as the use of smartphones and electronic devices increases. This material can be used in a variety of different fields.

In addition, the corrosion plate used in the present invention is a ceramic material, in particular, alumina particles are pressed and molded.

In the description of the corrosion plate of the present invention, in the registration number 10-1548110 to which the present applicant has previously registered, in the color lock manufacturing method for printing color on a contact lens according to claim 1, a curing agent is added to the transparent coating polymer. Stirring; Coating treatment step of forming a coating layer by applying the stirred transparent coating polymer on the upper mold; A color printing step of printing colors using a pad device on the outer surface of the coating layer applied on the upper mold; Stirring by adding a curing agent to the lens polymer; Manufacturing a lens by introducing the stirred lens polymer between the upper and lower molds; Including, the transparent coating polymer is 2-hydroxyethyl methacrylic acid (2-HEMA; 2-Hydroxyethyl methacrylate) 20 to 60% by weight, 2.2'-azobisisobutyro Nitrile (AIBN; 2.2'-Azobisisobutyronitrile) 0.3 to 5% by weight, methyl methacrylate (MMA; Methylmethacrylate) 0.3 to 20% by weight, allyl methacrylate (Allylmethacrylate) to contain 10 to 20% by weight as raw materials, Putting the raw materials in a polymerization vessel and stirring for 1 to 8 hours; Putting the polymerization vessel in a water heating heater maintaining a temperature error range of -10 to +10°C and performing polymerization while adding an accelerator as a raw material for 5 to 10 hours; Stopping the polymerization when the polymer is in a gel state, moving to another container, and cooling the heat while stirring; When the heat of the polymer cools, it is transferred to an opaque storage container, placed in -5 to 20°C and stored in a refrigerator, and 0.5 to 30% by weight of a curing agent is added to 70 to 99.5% by weight of the transparent coating polymer. While stirring, it is prepared by stirring for 5 to 60 minutes until all the curing agent is dissolved, and a corrosion plate is used in the coating treatment step of forming a coating layer by applying the stirred transparent coating polymer on the upper mold. Is corroded in a numerical range of 4.0 to 12 mm outer diameter, 1.5 to 6.5 mm inner diameter, and 3 to 20 μm in depth, and is applied on the upper mold using a pad device 300 after burying a transparent coating polymer on the corrosion plate. , In the color printing step, a corrosion plate is used, but the corrosion plate is corroded in a numerical range of an outer diameter of 5.0 to 12.4 mm, an inner diameter of 1.5 to 7.0 mm, and a depth of 3 to 25 μm, and color ink is applied to the corrosion plate. , Using the pad device 300, to print the color on the outer surface of the coating layer, the step of heat-treating the manufactured lens is to heat treatment at 60 to 130 °C for 20 to 90 minutes, and, in addition, the pad device 300 Is composed of a pad 310 and a handle 320 coupled to the pad 310, the handle 320 is configured to be detachable from the pad 310, and the pad 310 has a hole in the center of the upper surface ( 311) is formed, and a protrusion 321 is formed on the lower surface of the handle 320 to be coupled by inserting the protrusion 321 into the hole 311, and the protrusion 321 is formed in the center and a protrusion ( A method of manufacturing a color lock for printing colors on a contact lens, characterized in that a plurality of grooves 322 are formed radially around the 321), is described.

For the corrosion plate, in the present invention, a ceramic corrosion plate is used.

The reason for the use of the ceramic, particularly alumina particles, is that ITO nanoparticles are included in the contact lens molding material, and ITO nanoparticles are also included in the pigment and dye mixture added to the contact lens for pattern printing by being buried on a pad, so the corrosion The plate is formed by compression molding alumina particles, which are ceramic materials, in harmony with the ITO nanoparticles each contained in the contact lens molding material and the pigment and dye mixture.
In addition, contact lenses manufactured using ceramic materials, particularly soft alumina particles, are of excellent quality, and in particular, ITO nanoparticles are uniformly applied throughout, resulting in a product without defects on the surface.

In addition, the corrosion plate is an etching method for manufacturing a contact lens, and a laser corrosion method for realizing a delicate color design is used.

The general etching processing method of the corrosion plate is the conventional acid corrosion method, but this has a corrosion depth of 15 μm to 17 μm, and the dot size is also corroded with acid, so the dot is not very delicate.

Therefore, in the present invention, the corrosion plate is etched by laser processing, and the corrosion depth is 18 μm and the halftone point is small, so it is softer than the existing acid corrosion. Therefore, it is possible to improve the efficiency of a contact lens material containing fine ITO nanoparticles of nano size.

And there is an effect that precise design expression is possible.

Therefore, the contact lens manufacturing method of the present invention supplements the moisture content and wettability by adding PEGMEMA to HEMA, which is a basic contact lens material, supplements the UV blocking function by adding 2,4-dihydroxybenzophenone, and adds ITO nanoparticles. By complementing the electromagnetic wave blocking function, it is possible to manufacture a high-functional contact lens with high wettability, high water content, UV blocking, and electromagnetic wave shielding functions, and by using PEGMEMA, 2,4-dihydroxybenzophenone and ITO nanoparticles, smartphones and electronic devices As the use of the material increases, it has a remarkable effect, such as that it can be used in various other fields as a material that can supplement the necessary physical properties.

In addition, the present invention has a remarkable effect in that the corrosion plate made of ceramic is used during manufacturing, so that the quality is excellent, there are no defects on the surface, and a delicate color shape is implemented.

Claims (2)

HEMA (2-hydroxyethyl methacrylate) 84.64~87.19% by weight, PVP (polyvinylpyrrolidone) 2.61% by weight as an irritation reducing agent, EGDMA (ethylene glycol dimethacrylate) 0.44% by weight as a crosslinking agent, AIBN (azobis iso butyronitrile) 0.17% by weight as an initiator during polymerization , Hydrophilic monomer PEGMEMA (poly(ethylene glycol) methyl ether methacrylate) 9.04% by weight, DB (2,4-dihydroxybenzophenone) 0.5~3.00% by weight as a sunscreen, ITO (Indium Tin Oxide) nanoparticles 0.05~0.10 as an electromagnetic wave blocker In the contact lens manufacturing method using a corrosion plate, the contact lens is manufactured by copolymerizing by adding weight% as a contact lens molding material,
Since ITO nanoparticles are included in the contact lens molding material, and ITO nanoparticles are also included in the pigment and dye mixture that is added for pattern printing by being buried on a pad on the contact lens, the corrosion plate is the contact lens molding material and pigment, Alumina particles, a ceramic material, are pressed and molded in harmony with the ITO nanoparticles contained in each dye mixture
The corrosion plate is an etching method for manufacturing a contact lens, and a method of manufacturing a contact lens using a laser corrosion method for realizing a delicate color design.
delete

Images