KR20160042660A - Functional contact lens - Google Patents

Abstract

The present invention relates to a functional contact lens. An objective of the present invention is to provide a functional contact lens which improves stability from an eye disease; has an antibiotic function; detoxifies a harmful active oxygen species; generates negative ions; emits far-infrared radiation to prevent eyeball fatigue and protects a cornea; and has an ultraviolet area blocking effect without affecting a property of a material of the contact lens. The functional contact lens comprises trumarin, chitosan and benzophenone to emit far-infrared radiation and negative ions, and provides an antibiotic function and an ultraviolet radiation blocking function. A source technology of a functional contact lens is able to be secured in a domestic and foreign market by domestically producing such lens, as well as improving market share.

Description

Functional Contact Lens {FUNCTIONAL CONTACT LENS}

The present invention relates to a functional contact lens, and more particularly, to a functional contact lens including trumalin, chitosan, and benzophenone having anion emission and circular circular radiation effect, Lens.

With the development of multimedia, the increase in the age of social activities, and the diversification of visual information, the population of eyeglasses and contact lenses, which are eye medical instruments, is increasing each year, In the industrialized society, diverse functions of medical devices are required. Among them, contact lenses are preferred not only for eyeglasses but also for outdoor activities and sports activities. Contact lenses are used not only for general vision correction but also for aesthetic needs and are widely used in younger than 30s and their use is increasing. Particularly, adolescents who are interested in appearance tend to prefer to wear contact lenses rather than glasses. Color contact lenses are becoming more and more difficult. According to the Korea Eyeglasses Newspaper survey in 2013, it was found that the first school girls started wearing in the upper grade (48.7%) and the high school girls started in middle school (40.8%). In recent years, as the aging population and the aging population of the world have increased in recent years, contact lens wearers are gradually increasing their age to the age of presbyopia, Is expanding widely as a new consumer segment emerges. Now contact lenses are used not only for past simple vision correction but also cosmetically, so they become medical products that are widely used regardless of whether they are young or old.

However, it has various and useful features of ophthalmic devices, but due to careless wearing of lenses and contact lens management of users, complications that cause blurred vision such as keratitis, corneal erosion, corneal ulcer, and corneal neovascularization are caused, Due to the functional limitations of lenses, lens wearers complain of inconvenience and difficulty, and their eyes are exposed to eye disease.

The disadvantage of contact lenses is that it is a secure eye care device and its wearing rate is gradually increasing. However, the disadvantages of glasses have been partially compensated, but it has caused problems with only contact lenses in order to wear them directly on the eyes. Eyes have a physiologically appropriate temperature and humidity and are easily exposed to many bacteria. As the wear of contact lenses becomes more common, the side effects of the contact lenses are increased, so that ophthalmologic diseases are acutely and rapidly occurring. Bacterial conjunctivitis is an ophthalmic disease caused by these bacteria. Bacterial conjunctivitis is caused by acute mucinous conjunctivitis, chronic bacterial conjunctivitis, caustic membrane and conjunctivitis, and pathogens such as staphylococci and streptococci that are easily accessible in daily life.

In addition, since the contact lens is used in direct contact with the cornea of the eyeball, various problems occur in the cornea. Among them, ocular diseases of wearers are caused by the problem of poor supply of oxygen. The cornea receives oxygen from tears, blood vessels around the cornea, blood vessels of the conjunctiva, etc., but is mainly supplied from the atmosphere of tears. The cornea must be supplied with oxygen and nutrients as needed to ensure smooth cell division and maintain a healthy eye condition. Since soft contact lenses cover the wider area than the cornea, there is almost no movement, and there is no clearance of tear circulation, and the supply of oxygen becomes ineffective. Such smooth oxygen supply is not performed, and harmful active oxygen that can be produced by hypoxia is generated, which causes problems in the cornea.

The quality of life is getting higher as the industry is highly developed and the economy grows faster than in the past. As a result, many people have increased interest in health as well as interest in product functionality. Among them, a contact lens, which is a medical polymer for the purpose of correcting vision, also needs a contact lens having a function. Recently, ultraviolet rays reaching the surface of the ozone layer due to environmental pollution are increasing. Excessive investigation of ultraviolet rays causes various disease problems in the eyes. Therefore, there is a further need for a functional contact lens that protects the eye from ultraviolet radiation. In particular, UV exposure increases the incidence of cataract, a major cause of blindness in the elderly. In order to protect the eyes from ultraviolet rays, not only colored spectacle lenses but also ordinary spectacle lenses have been used for obtaining ultraviolet rays. From the past, spectacle lenses and sunglasses have been shielding ultraviolet rays by surface treatment technology. However, in recent years, contact lenses, which are used for correction of vision, have been focused on basic functions such as wearing comfort in place of glasses. Therefore, except for disposable contact lenses, development of a special functional technology called ultraviolet shielding is still insufficient . In case of general and tinted lenses, it is possible to shield ultraviolet rays through its material properties and surface coating, but it is difficult to block ultraviolet rays because of the difficulty of surface coating and the material properties most commonly used in contact lenses.

On the other hand, Korean Patent Laid-Open No. 10-2006-0116407 (method of manufacturing contact lens material), Korean Patent No. 10-0878053 (antibacterial contact lens containing Naringin and method of manufacturing the same) .

Disclosure of the Invention The present invention has been made to solve the above problems of the prior art, and it is an object of the present invention to provide a functional contact lens including trumarin, chitosan and benzophenone, It has been confirmed that it is effective to prevent eye fatigue and cornea by improving toxicity and improving antioxidant ability as well as detoxifying harmful active oxygen, emitting negative ions and radiating far infrared rays, and maximizing the effect of contact lens It is experimentally confirmed that the blocking effect of the ultraviolet ray region is excellent and the present invention is completed.

Finally, it is an object of the present invention to provide a functional contact lens comprising trumarin, chitosan and benzophenone.

In order to achieve the above object, the present invention provides a functional contact lens comprising trumarin, chitosan and benzophenone.

The chitosan is produced by deacetylating chitin.

The benzophenone is 2-Hydroxy-4-methoxy-benzophenone represented by the following formula (1).

[Chemical Formula 1]

The benzophenone is 2,4-Dihydroxy-benzophenone represented by the following formula (2).

(2)

제공한다.

to provide.

According to the present invention as described above, it is possible to improve safety from ophthalmic diseases, to have an antibacterial function, to detoxify harmful active oxygen, to generate anion and to radiate far-infrared rays to prevent eye fatigue and to protect the cornea, It is possible to provide a functional contact lens including trumarin, chitosan and benzophenone, which have excellent blocking effect on the ultraviolet ray region without affecting the ultraviolet ray and the anion, Functional contact lens having a blocking function can be provided. Localization of such a lens can secure not only the original technology of the multi-function contact lens in the domestic and overseas markets, but also the market share can be improved.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process flow diagram for manufacturing a functional contact lens of the present invention. FIG.
Figure 2 shows the chemical structure of chitin and chitosan.
Figure 3 shows the antimicrobial mechanism of chitosan.
Fig. 4 is a schematic diagram showing an ultraviolet ray, a visible ray, and an infrared ray region of sunlight;
Fig. 5 is a schematic diagram showing the influence of UV on the eyeball. Fig.
6 is a photograph showing ocular disease caused by ultraviolet rays.
7 is a functional contact lens according to the present invention.

Hereinafter, the present invention will be described in detail.

The present invention provides a functional contact lens comprising trumarin, chitosan and benzophenone. The manufacturing process of the base functional contact lens according to the present invention is as shown in Fig.

On the other hand, the incidence of eye disease is increasing due to the limitations of materials that only soft contact lenses have. Thus, a main monomer and an auxiliary monomer material for the production of the functional contact lens of the present invention were selected and developed.

(1) 2-Hydroxyethyl methacrylate (HEMA)

HEMA is the most commonly used monomer in soft contact lenses and is the most widely used material. It is a polymer of 2-hydroxyethyl methacrylate (HEMA) modified with methylene hydroxyl (CH ₂ OH) in MMA It is a very stable material such as pH, temperature, osmotic pressure. It absorbs water due to the hydroxyl group (OH) in the side-chain and has a water content of about 38%.

(2) Methacrylic acid (MAA)

MMA, an auxiliary monomer required for lens development, is a colorless viscous liquid that dissolves in warm water and is mixed with most organic solvents. In particular, this study is used to increase the water content of hydrogel materials.

(3) Vinyl pyrrolidone (NVP)

NVP, an auxiliary monomer used to increase the water content of the lens, is used to increase the moisture content and wettability of silicone hydrogels. It is a material with a high water content and can have a wide range of water content ranging from 50 to 80% under suitable conditions, and research and development is carried out using this monomer to increase the oxygen permeability. The material of the soft contact lens is hydrogel polymers containing 2-Hydroxyethyl methacrylate (HEMA) as a basic monomer and has a structure having a very flexible structure including a large amount of water. Hydrogels are made by polymerization of various monomers, initiators, cross-linkers, etc. Depending on the amount of initiator and crosslinking agent, various physical properties are different. In particular, when the amount of cross-linking agent is increased, cross- The hardness hardens, the water content decreases, and the refractive power becomes higher. Accordingly, in the present invention, a lens capable of maximizing the performance of a soft contact lens by optimally controlling the amounts of the initiator and the cross-linking agent has been developed. As the crosslinking agent, azobisisobutyronitrile was used, and tetraethylene glycol diacrylate or ethylene glycol dimethacrylate was used as a crosslinking agent. Ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent has two methacrylate groups in one monomer, and the main function is to stabilize the polymer. If the crosslinking agent is used excessively, the hardness becomes lower, the water content decreases, and the stretchability decreases. Therefore, in the present invention, the compounding ratio was optimized with the amount optimized through experiments. It uses ultraviolet ray blocking function by using benzophenone system in lens raw material, and it uses tourmaline which is a natural material to have anion generation and far infrared ray radiation function. We have also developed a multi-functional contact lens with antimicrobial properties utilizing natural chitosan, and developed contact lenses with various functions in one lens.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.

Unlike the convenient points of various contact lenses, typical defects are not suitable for people with special allergies or hypersensitivity due to various kinds of pathogenic fungus virus viruses that are produced in contact lenses. . Therefore, we developed a functional contact lens which can provide negative ion and far infrared ray emission effect, anti-bacterial resistance and ultraviolet ray blocking function to the contact lens material.

(1) "Tourmaline" function of generating far-infrared rays and negative ions

We have developed a functional contact lens to detoxify harmful active oxygen by far infrared ray and negative ion generation beyond simple sight supplement and protection function of contact lens. The choice of raw materials is important for this.

Accordingly, in the present invention, trumarin is selected as a core functional raw material for developing a functional contact lens that utilizes a characteristic of generating far infrared rays and anions among various materials in which far-infrared rays and anions can be generated. Tourmaline is a well known material for its excellent detoxification. Tourmaline emits far infrared rays and negative ions that boost body temperature, promote blood circulation in the body, increase immunity, relieve pain, and release harmful heavy metals in the body. Tourmaline has the ability to detoxify harmful activated oxygen with its excellent therapeutic effect, and is known as the only material on the planet that emits far infrared rays and negative ions, and makes electrons permanent. The 0.06 mmA electricity that tourmaline releases into minerals found in modern scientific studies is consistent with the weak currents that occur when plants and animal cells nourish to grow.

Tourmaline emits a large amount of negative ions and has the only energy on Earth that has its own energy and has a permanent electrical property. Anion promotes cell metabolism and promotes vitality, cleanses blood, has the effect of restoring nervousness, fatigue, and appetite. Anions are called air vitamins. Anions have this property when a stable molecule receives electrons for some reason and becomes electrically charged. The phenomenon that electrons protrude from the surface of a material is called electron emission. Anion generation generates ions in large quantities using this principle to ionize the surrounding materials. In the human body, however, leukocytes and macro-sterilized virus cells produce active oxygen, a more potent oxidizing substance than oxygen, which causes oxidation to kill viruses invaded from the outside. However, inhalation of air pollutants or ingestion of food additives Or ultraviolet rays, if stressed, a large amount of active oxygen occurs and attacks healthy cells.

In particular, in the case of a cornea which is supplied with nutrients from the oxygen in the air, such as wearing a contact lens, hypoxia is generated due to a deficient oxygen supply, resulting in harmful free radicals, resulting in eye fatigue and corneal disease. In general, when the eyes are open, the oxygen partial pressure drops to about 155 mmHg, so even if you sleep for 7 hours without wearing the lens, about 4% of corneal edema occurs. The initial fit is good, but only the small amount of oxygen permeates the material itself, so only the oxygen dissolved in the tears absorbed by the lens can be supplied. As a result, dry eye syndrome and hypoxia caused by hyperoxia (hyperemia) appear to inhibit the physiology of the cornea by reducing the number of cells and nerves of the cornea is reduced immunity and decreased perception of the nerve leads to continued wear of the lens side effects I raise it. The anion has an action to neutralize active oxygen with such side effects and strong toxicity. Therefore, the anion generated by the turmarine eliminates toxicity by giving electrons to the excess oxygen generated in the oocyte and body. In addition, the effect of anions has beneficial effects such as blood purification, cell activation, increase in resistance, and autonomic regulation. Tourmaline is produced by electricity generated by minute heat so that the weak electric current flows, so that it comes into contact with the heat (body temperature) of the human body, so that heat is transferred to the body, which stimulates the menstrual blood, thereby improving the peripheral circulation, It is known to have antibacterial, deodorizing and cleaning effect. It has the effect of dislocation treatment such as improvement of the constitution and purification of blood by the cell activation function. Due to the nature of tourmaline to be used in this research, large amounts of far-infrared rays are radiated to deeply cover the cells, promote blood circulation and stimulate metabolism, thereby helping to recover fatigue, gastrointestinal activation, relieve pain and shoulder stiffness, Of course, it has antibacterial and bactericidal action.

As far as the absorption rate of far infrared rays is concerned, it means that the region reaching the retina based on the cornea, waterproofing, and retina of the eye is IR-A (near-infrared region), and that when the emissivity is high, tissue damage may be caused by IR-A . However, in the case of IR-C (far infrared ray region) used in the present invention, almost all of it is absorbed in the cornea and waterproofing of the eye, so that it does not interfere with the eye image relationship and can maximize the effect. In order to take advantage of the excellent properties of tourmaline, we have developed a functional contact lens as a raw material for making contact lenses and functional materials. One of the characteristics of the product that should be in direct contact with the eye is the safety of the material. Regarding the safety of tourmaline, in October 1996, it was used as a health-care cosmetic raw material and classified as safety that can be used on the skin. Using the characteristics and effects of such tourmaline, a functional soft contact lens emitting far- Respectively.

(2) chitosan for antimicrobial functional contact lenses

As the low - carbon green growth industry is getting attention, chitin and chitosan, which are natural polymer materials, are attracting attention as functional new materials. chitosan has excellent safety and various physiological activities such as macrophage activation, cholesterol lowering, antibacterial action, blood pressure lowering, bifidus growth, antihypertensive, anti-obesity, anti-cancer, antidiabetic and uric acid metabolism promotion have been reported. Chitin is a polymer contained in the cell walls of plants such as crabs, shrimp, and other crustaceans and algae and fungi. In recent years, it has been widely used as a biopolymer. However, since chitin is not soluble in organic solvents, it is not as effective as cellulose, which is a natural polymeric material. In 1970, chitosan was produced by deacetylation of chitin together with solvent development of chitin. It has biocompatibility, biodegradability and non- Which is used in various forms. The chemical structure of chitin and chitosan is shown in Fig.

Chitosan is an acetamide group (-NHCOCH _3), acetyl group (-COCH ₃₎ away from the coupling structure is in a state dissolved in the natural (+) ions, only the natural cations of the global ecosystem (+) to the charging with the material of chitin . The amino group and the hydroxyl group (-OH) in the molecule are viscous and moisturizing, and exhibit a biological function of preserving the ecosystem, such as activation of cell immunity. On the other hand, it has been found that chitosan and its hydrochloride-degradation products have an antimicrobial effect against plant pathogenic fungi, so that a study on the functional effect has progressed rapidly. Recently, many studies have been carried out to apply the antimicrobial activity in various forms .

The antimicrobial function of chitosan is known to be caused by the cationized amino group (-NH3 +) (see FIG. 3). Ionic bonds between the cationic amino group and the negative charge such as the phospholipid that constitutes the cell wall of the microorganism occur. As a result, the cell membrane tissue is destroyed, and the plasmids inside the cell are leaked, causing the microorganisms to die.

As long as the cation of chitosan can be contacted with the microorganism, the antimicrobial effect lasts. Using these properties, it is possible to impart antimicrobial properties to contact lenses by immersing them in an organic acid mixture of chitosan or by pulverizing chitosan into fine particles and mixing them in solution. Among the various applications of chitin and chitosan, contact lenses worn directly on the cornea may be very useful because of the possibility of causing various ophthalmologic side effects and ocular diseases due to bacteria and fungi. In fact, side effects and eye diseases caused by contact lenses have been pointed out as serious problems in many researches. To reduce these problems, chitosan is selected as a key ingredient to develop functional contact lenses with excellent antibacterial properties. Chitosan inhibits the growth of harmful fungi such as Escherichia coli and Pseudomonas aeruginosa and Staphylococcus aureus, but it helps the growth of beneficial lactic acid bacteria. As described above, chitosan neutralizes the anionic cell surface of harmful bacteria, thereby inhibiting the growth of harmful bacteria. Lactic acid bacteria produce more lactic acid than the harmful bacteria on the cell wall, so chitosan gives a positive effect on the growth of lactic acid bacteria . On the other hand, since contact lenses that are commercially available are most important in terms of selective permeability of oxygen, the cornea must be continuously supplied with oxygen during the wearing of the lens, and the generated carbon dioxide must be discharged to the outside. The lack of oxygen in the cornea, together with the accumulation of carbon dioxide and metabolites, accompanies the pain. Through the above process, the present invention has developed an antibacterial contact lens to minimize the eye disease incidence of lens wearers by maximizing antibacterial activity by adding natural chitosan to soft contact lenses.

(3) "benzophenone" for ultraviolet protection function

Humans are directly or indirectly affected by the sun while living, and the effects of the sun may or may not have a beneficial effect on the human body.

Unlike skin, in which the skin of the human body is thicker and can be partially adapted to ultraviolet light by a black-and-white ride, the eye does not have its own adaptive mechanism. In this way, human body structure is most exposed to the sun and can easily be affected by harmful rays. Moreover, the visual organs have no special protection and are more directly affected by exposure to the sun. The cornea of the eye mainly absorbs UV-B and UV-C with a wavelength of less than 300 nm, and the ultraviolet ray having a wavelength longer than 300 nm is transmitted through the cornea to the lens and absorbed. Depending on the degree of absorption of ultraviolet rays, it may cause acute effects such as photocleritis and conjunctivitis, such as arc eye, and long term effects such as cataract. Photocleritis and conjunctivitis are most likely to occur at a wavelength of 270-280 nm and are characterized by symptoms such as pain, tears, redness, and foreign body, and are alleviated about two days later (see FIGS. 4 and 5). Cataracts are a type of eye damage that causes wavelengths of 290-310 nm to be the most effective wavelengths, causing clouds to appear on the lens and loss of clarity. As modern medicine developed, ophthalmologists began to pay attention to the effects of ophthalmologic diseases such as cataracts and rays including ultraviolet rays. Most of the ultraviolet rays projected to the eye are absorbed by the cornea and lenses such as the thin film on the front side. However, the electromagnetic waves of 295 nm or more are partially exposed to the anterior eye tissue and the lens, and the retina is partially exposed to ultraviolet rays. Ophthalmologic diseases associated with UV-B exposure include photokeratitis, corneal or posterior subcapsular cataract due to acute exposure, and corneal or subcapsular cataract cortical or posterior subcapsular cataract). Global blindness (blindness) is estimated at about 35 million, of which about half are thought to be caused by cataracts. It is not known exactly how much of the cataracts caused by ultraviolet rays (UV-B) will occupy, but it is estimated to be about 20%.

In addition, not only the denaturation of the lens by ultraviolet rays but also the corneal damage are various, and acute injury causes keratitis (see FIG. 6). It is known that DNA damage by photochemical action, abnormal protein synthesis, denaturation of protein structure, electrolyte imbalance due to cell membrane damage, and accumulation of various chemical and biological changes affect the corneal epithelial cells have. When ultraviolet rays reach the eye, they are absorbed by different tissues in the eye along the wavelength. Generally, short wavelength UV-B ultraviolet rays physiologically actively affect the eye, and most of it is absorbed by the cornea. UV-A ultraviolet rays of relatively long wavelength are partially absorbed by the cornea and lens, but reach the retina. In this way, as the area of the eyeball absorbed by the wavelength is different, the kinds of the eyeballs caused may vary. Symptoms of eye-related side effects caused by ultraviolet exposure are mostly absorbed by the anterior segment of the UV-B, which can lead to short-term or long-term disease related to the affected area.

Therefore, in this study, a benzophenone-based material represented by the following formulas (1) and (2) was used in a commercially available 2-heme soft lens exhibiting various health benefits such as antibacterial, antiallergic, Functional contact lenses have been developed to minimize the side effects such as ultraviolet rays and harmful rays when wearing lenses.

[Chemical Formula 1]

(2)

Having described specific portions of the present invention in detail, those skilled in the art will appreciate that these specific embodiments are merely preferred embodiments and that the scope of the present invention is not limited thereby. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (4)

Functional contact lenses comprising trumarin, chitosan and benzophenone.
The method according to claim 1,
The functional contact lens according to claim 1, wherein the chitosan is prepared by deacetylating chitin.
The method according to claim 1,
Wherein the benzophenone is 2-Hydroxy-4-methoxy-benzophenone represented by the following formula (1).
[Chemical Formula 1]

The method according to claim 1,
Wherein the benzophenone is 2,4-Dihydroxy-benzophenone represented by the following formula (2).
(2)

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