KR102163368B1 - 플루티카손 프로피오네이트 형태 1의 제조 방법 - Google Patents

플루티카손 프로피오네이트 형태 1의 제조 방법 Download PDF

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Publication number
KR102163368B1
KR102163368B1 KR1020197026105A KR20197026105A KR102163368B1 KR 102163368 B1 KR102163368 B1 KR 102163368B1 KR 1020197026105 A KR1020197026105 A KR 1020197026105A KR 20197026105 A KR20197026105 A KR 20197026105A KR 102163368 B1 KR102163368 B1 KR 102163368B1
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KR
South Korea
Prior art keywords
solvent
fluticasone propionate
slurry
solution
micrometers
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Expired - Fee Related
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KR1020197026105A
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English (en)
Korean (ko)
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KR20190107165A (ko
Inventor
마르틴 데이빗 티세허르스트
이반 마르지아노
엘레프테리오스 코우고울로스
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화이자 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197026105A 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법 Expired - Fee Related KR102163368B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161505612P 2011-07-08 2011-07-08
US61/505,612 2011-07-08
PCT/US2012/045660 WO2013009591A1 (en) 2011-07-08 2012-07-06 Process for the preparation of fluticasone propionate form 1

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147003035A Division KR20140048237A (ko) 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207028182A Division KR20200117056A (ko) 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법

Publications (2)

Publication Number Publication Date
KR20190107165A KR20190107165A (ko) 2019-09-18
KR102163368B1 true KR102163368B1 (ko) 2020-10-08

Family

ID=47506422

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020197026105A Expired - Fee Related KR102163368B1 (ko) 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법
KR1020207028182A Ceased KR20200117056A (ko) 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법
KR1020147003035A Ceased KR20140048237A (ko) 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020207028182A Ceased KR20200117056A (ko) 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법
KR1020147003035A Ceased KR20140048237A (ko) 2011-07-08 2012-07-06 플루티카손 프로피오네이트 형태 1의 제조 방법

Country Status (10)

Country Link
US (2) US10370402B2 (https=)
EP (1) EP2729480A4 (https=)
JP (2) JP2014520848A (https=)
KR (3) KR102163368B1 (https=)
CN (2) CN106977575A (https=)
AU (1) AU2012282936B2 (https=)
CA (1) CA2840401C (https=)
MX (2) MX376564B (https=)
WO (1) WO2013009591A1 (https=)
ZA (1) ZA201309531B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102163368B1 (ko) * 2011-07-08 2020-10-08 화이자 리미티드 플루티카손 프로피오네이트 형태 1의 제조 방법
AU2013259872B2 (en) 2012-05-08 2018-06-28 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US9796750B2 (en) 2014-02-07 2017-10-24 Mylan Laboratories Ltd. Process for the purification of fluticasone propionate using a ketone solvent and water as anti-solvent
CN111662353A (zh) * 2019-03-05 2020-09-15 上海谷森医药有限公司 一种糠酸氟替卡松晶型1的制备方法
CN114040752A (zh) * 2019-04-10 2022-02-11 优普顺药物公司 制备期望的粒度分布和形态的药物晶体的方法
CN110759960B (zh) * 2019-10-30 2021-03-23 山东赛托生物科技股份有限公司 一种丙酸氟替卡松的精制方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1291A (en) 1980-02-15 1985-10-18 Glaxo Group Ltd Androstane 17 beta carbothioates
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
GB9925934D0 (en) * 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
GB0015981D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0201400D0 (en) * 2002-01-22 2002-03-13 Glaxo Group Ltd Novel apparatus and process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
EP1534733A2 (en) * 2002-06-20 2005-06-01 Sun Pharmaceuticals Industries Ltd. Convenient synthesis of s-fluoromethyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- methyl-17alpha-propionyloxy-3-oxoandrosta-1, 4-diene-17beta-carbothioate
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
US7314516B2 (en) * 2004-12-29 2008-01-01 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device and process
KR102163368B1 (ko) * 2011-07-08 2020-10-08 화이자 리미티드 플루티카손 프로피오네이트 형태 1의 제조 방법

Also Published As

Publication number Publication date
CA2840401A1 (en) 2013-01-17
US20140141247A1 (en) 2014-05-22
KR20200117056A (ko) 2020-10-13
JP2014520848A (ja) 2014-08-25
CA2840401C (en) 2016-05-17
ZA201309531B (en) 2014-08-27
KR20140048237A (ko) 2014-04-23
CN103649104A (zh) 2014-03-19
MX376564B (es) 2025-03-07
US10370402B2 (en) 2019-08-06
EP2729480A4 (en) 2014-12-31
KR20190107165A (ko) 2019-09-18
AU2012282936A1 (en) 2014-01-16
MX2014000192A (es) 2014-04-25
JP2017031161A (ja) 2017-02-09
WO2013009591A1 (en) 2013-01-17
EP2729480A1 (en) 2014-05-14
US20200024298A1 (en) 2020-01-23
CN106977575A (zh) 2017-07-25
MX2020011330A (es) 2020-11-24
AU2012282936B2 (en) 2016-11-10

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