KR102149516B1 - Compositions for preventing or treating oral diseases using omija and banana extract - Google Patents
Compositions for preventing or treating oral diseases using omija and banana extract Download PDFInfo
- Publication number
- KR102149516B1 KR102149516B1 KR1020180164325A KR20180164325A KR102149516B1 KR 102149516 B1 KR102149516 B1 KR 102149516B1 KR 1020180164325 A KR1020180164325 A KR 1020180164325A KR 20180164325 A KR20180164325 A KR 20180164325A KR 102149516 B1 KR102149516 B1 KR 102149516B1
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- KR
- South Korea
- Prior art keywords
- extract
- schisandra chinensis
- preventing
- banana
- tooth decay
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/312—Foods, ingredients or supplements having a functional effect on health having an effect on dental health
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- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물 에 관한 것으로서, 더욱 상세하게는 오미자와 바나나 추출물의 복합소재를 설정된 중량비로 배합하여 제조된 조성물을 이용함으로써, 항충치활성효과와 현저한 향균 기능성을 부여한 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물에 관한 것이다.It relates to a composition for preventing or treating tooth decay and periodontal disease using Schisandra chinensis extract, and more particularly, by using a composition prepared by mixing a composite material of Schisandra chinensis and banana extract in a set weight ratio, anticaries activity effect and remarkable antibacterial It relates to a composition for preventing or treating tooth decay and periodontal disease using an extract of Schisandra chinensis imparting functionality.
Description
본 발명은 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물에 관한 것이다.The present invention relates to a composition for preventing or treating tooth decay and periodontal disease using a Schisandra chinensis extract.
치아건강의 개념이 사회생활개념으로 변화되면서 구강건강에 관한 관심이 증대되고 있으며 구강질환의 예방과 치료 및 기능 상실 재활뿐만 아니라, 사회생활을 하는데 있어 중요한 대인관계의 장애가 되는 구취(口臭)에 대한 관심도 높아지고 있는 실정이다.As the concept of dental health has changed to the concept of social life, interest in oral health is increasing, and not only for the prevention and treatment of oral diseases and rehabilitation for loss of function, but also for bad breath, which is an important obstacle to interpersonal relationships in social life. Interest is also increasing.
치아건강을 악화시키는데 일조하는 기호성 식품은 기호도를 증진하기 위해 많은 양의 당분을 첨가하는데 대표적인 것이 액상과당과 백설탕이다. 특히 액상과당은 설탕보다 1.7배의 단맛을 내면서도 값이 저렴하여 식품회사에서 널리 사용되고 있는 성분이다. 상기 언급된 당분과 세균이 서로 유착되어 플라그를 형성하면, 플라그 속의 세균에 의해 산이 생성되며, 이는 에나멜 표면을 탈회하여 충치를 야기한다.Favorable foods that contribute to deteriorating dental health include liquid fructose and white sugar that add a large amount of sugar to improve the palatability. In particular, liquid fructose is an ingredient widely used in food companies because it has 1.7 times sweeter taste than sugar and is inexpensive. When the above-mentioned sugar and bacteria adhere to each other to form plaque, acid is produced by bacteria in the plaque, which demineralizes the enamel surface and causes tooth decay.
이에 따라, 본 발명은 오미자와 바나나 복합 추출물을 이용하여 충치와 치주질환 예방 또는 치료용 조성물을 제공함으로써, 구강 내 플라그 형성 억제 및 충치 유발 균주의 생육을 저해하고자 한다.Accordingly, the present invention provides a composition for preventing or treating tooth decay and periodontal disease by using a composite extract of Schisandra chinensis and a banana, thereby inhibiting the formation of plaque in the oral cavity and inhibiting the growth of a tooth-causing strain.
본 발명은 충치 원인균의 생육을 현저하게 감소시킬 수 있는 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물 및 이를 포함하는 구강용 제품을 제공하는 것을 목적으로 한다.An object of the present invention is to provide a composition for preventing or treating tooth decay and periodontal disease using a banana extract that can significantly reduce the growth of tooth decay causative bacteria, and an oral product comprising the same.
또한, 본 발명은 치주질환 및 잇몸염증을 유발하는 균주에 대해 우수한 향균 활성을 갖도록 하는 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물 및 이를 포함하는 구강용 제품을 제공하는 것을 목적으로 한다.In addition, the present invention aims to provide a composition for preventing or treating tooth decay and periodontal disease using a banana extract and a composition for preventing or treating tooth decay and periodontal disease, which has excellent antibacterial activity against strains causing periodontal disease and gum inflammation, and an oral product comprising the same do.
또한, 본 발명의 소비자가 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물로 제조된 치약, 가글링 제품, 구강 스프레이, 구강용 연고, 구강세정제 및 구강 청정제로 이루어진 제품을 섭취함으로써, 충치의 주 원인균의 생육을 억제시킬 수 있도록 하는 것을 목적을 한다.In addition, by ingesting a product consisting of toothpaste, gargling product, oral spray, oral ointment, mouthwash, and mouth freshener, the consumer of the present invention is prepared as a composition for preventing or treating tooth decay and periodontal disease using Omizawa banana extract, Its purpose is to suppress the growth of the main causative bacteria of.
또한, 본 발명의 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물을 용이하게 섭취 할 수 있는 기호성 제품에 첨가하여, 충치와 치주질환 예방용 제품이 오미자와 바나나 자체가 지니고 있는 기능성을 제공하도록 하는 것을 목적으로 한다.In addition, by adding the composition for preventing or treating tooth decay and periodontal disease using the extract of Schisandra chinensis of the present invention to a palatable product that can be easily ingested, the product for preventing cavities and periodontal disease has the functionality of Schisandra chinensis itself. It aims to provide.
본 발명은 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물에 있어서, 상기 오미자와 바나나가 10:1 내지 30:1의 중량 비율로 함유되되, 더욱 바람직하게는 오미자 추출물과 바나나 추출물이 18:1의 중량비율로 함유된 것을 특징으로 하는 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물을 제공하는 것을 특징으로 한다.In the present invention, in a composition for preventing or treating tooth decay and periodontal disease using a Schisandra chinensis extract, the Schisandra chinensis is contained in a weight ratio of 10:1 to 30:1, more preferably the Schisandra chinensis extract and the banana extract It characterized in that it provides a composition for preventing or treating tooth decay and periodontal disease using a banana extract, characterized in that it is contained in a weight ratio of 18:1.
상기 바나나 추출물은 스트렙토코커스 뮤탄스(streptococcus mutans), 스트렙토코커스 상기스(streptococcus sanguis), 스트렙토코쿠스 상귀니스(streptococcussanguinis), 스트렙토코쿠스 살리바리스 종 썰모필스(streptococcus salivaris subsp. thermophils), 포르피로모나스 긴기발리스(porphyromonas gingivalis)로 이루어진 군에서 선택된 하나 이상에 항균 효과가 있는 것을 특징으로 하는 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물을 제공하는 것을 특징으로 한다.The banana extract is streptococcus mutans, streptococcus sanguis, streptococcus sanguinis, streptococcus salivaris sp. thermophils, porphyro It characterized in that it provides a composition for preventing or treating tooth decay and periodontal disease using a banana extract, characterized in that it has an antibacterial effect on at least one selected from the group consisting of Monas gingivalis (porphyromonas gingivalis).
또한, 본 발명은 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물이 포함된 구강용 제품을 제공하는 것을 특징으로 한다.In addition, the present invention is characterized by providing a product for oral cavity containing a composition for preventing or treating tooth decay and periodontal disease using a banana extract.
또한, 본 발명은 치약, 가글링 제품, 구강 스프레이, 구강용 연고, 구강세정제 및 구강 청정제로 이루어지는 군중에서 선택되어 제조된 구강용 제품을 제공하는 것을 특징으로 한다.In addition, the present invention is characterized by providing an oral product manufactured by being selected from the group consisting of toothpaste, gargling products, oral sprays, oral ointments, mouthwashes, and mouthwashes.
또한, 본 발명은 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물이 포함된 제품을 제공하는 것을 특징으로 한다.In addition, the present invention is characterized in that it provides a product containing a composition for preventing or treating tooth decay and periodontal disease using the Schisandra chinensis extract.
상기 제품은 츄잉껌, 캔디, 초콜릿, 젤리로 이루어지는 군중에서 선택되어 제조된 제품을 제공하는 것을 특징으로 한다The product is characterized by providing a product manufactured by selecting from the group consisting of chewing gum, candy, chocolate, and jelly.
본 발명은 충치와 치주질환예방성분이 함유된 오미자와 바나나 추출물을 최적의 비율로 배함함으로써 충치유발 균주의 생육을 억제시킬 수 있는 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물 및 이를 포함하는 구강용 제품을 제공 할 수 있는 효과가 있다.The present invention is a composition for preventing or treating tooth decay and periodontal disease using a schisandra chinensis extract capable of inhibiting the growth of a tooth-causing strain by doubling the schisandra chinensis extract containing a tooth decay and periodontal disease prevention component in an optimal ratio, and the same There is an effect that can provide oral products containing.
또한, 본 발명은 바나나 추출물이 배합됨으로써, 치주질환 및 잇몸염증을 유발하는 균주에 대해 향균 효과를 제공할 수 있는 효과가 있다. In addition, the present invention has the effect of providing an antibacterial effect against strains that cause periodontal disease and gum inflammation by blending the banana extract.
또한, 본 발명의 소비자가 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물이 치약, 가글링 제품, 구강 스프레이, 구강용 연고, 구강세정제 및 구강 청정제로 이루어진 제품에 첨가됨으로써, 충치의 주 원인균의 생육을 억제시키고 충치와 치주질환을 개선시킬 수 있는 효과가 있다.In addition, by adding the composition for preventing or treating tooth decay and periodontal disease using Omizawa banana extract of the present invention to a product consisting of toothpaste, gargling product, oral spray, oral ointment, mouthwash and mouthwash, It has the effect of inhibiting the growth of causative bacteria and improving tooth decay and periodontal disease.
또한, 본 발명의 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물은 향균용 조성물 뿐만 아니라, 츄잉껌, 캔디, 초콜릿, 젤리 등과 같은 잔류시간이 비교적 긴 고형 식품에 첨가되어 충치와 치주건강의 예방 및 치료 용도로써, 효과적으로 이용될 수 있는 효과가 있다.In addition, the composition for preventing or treating tooth decay and periodontal disease using the Schisandra chinensis extract of the present invention is added to solid foods having a relatively long residence time such as chewing gum, candy, chocolate, jelly, etc., as well as antibacterial compositions. As a preventive and therapeutic use of, there is an effect that can be effectively used.
또한, 본 발명은 감미를 증진시킬 수 있는 바나나를 혼합함으로써, 오미자의 신맛 및 쓴맛으로 저감시킨 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물 및 그로부터 제조된 구강용 제품을 제공할 수 있는 효과가 있다.In addition, the present invention can provide a composition for preventing or treating tooth decay and periodontal disease using a banana extract reduced to acidity and bitterness of Schisandra by mixing bananas that can enhance sweetness, and oral products prepared therefrom. There is an effect.
도1은 오미자 추출물을 이용한 충치균의 향균 기능 결과를 도시한 그래프이다.
도2은 오미자와 바나나 추출물을 이용한 충치균의 향균 기능 결과를 도시한 그래프이다.1 is a graph showing the results of antibacterial function of caries bacteria using Schisandra chinensis extract.
2 is a graph showing the results of antibacterial function of caries bacteria using Schisandra chinensis extract.
본 발명은 오미자와 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물에 관한 것이다.The present invention relates to a composition for preventing or treating tooth decay and periodontal disease using a Schisandra chinensis extract.
본 발명을 충분히 이해하기 위해서 본 발명의 바람직한 실시예를 참조하여 설명한다. 본 발명의 실시예는 여러가지 형태로 변형될 수 있으며, 본 발명의 범위가 아래에서 상세히 설명하는 실시예로 한정되는 것으로 해석되어서는 안된다. 본 실시예는 당업계에서 통상의 지식을 가진 자에게 본 발명을 보다 완전하게 설명하기 위하여 제공되는 것이다.In order to fully understand the present invention, it will be described with reference to preferred embodiments of the present invention. The embodiments of the present invention may be modified in various forms, and the scope of the present invention should not be construed as being limited to the embodiments described in detail below. This embodiment is provided to more completely describe the present invention to those of ordinary skill in the art.
본 발명에 이용되는 조성물은 오미자와 바나나가 10:1 내지 30:1의 중량 비율로 함유된 것을 특징으로 하며, 바람직하게는 오미자와 바나나가 18:1의 중량 비율로 배합되는 것이 적절하다. 상기 오미자 추출물 내지 바나나 추출물이 설정된 중량 비율 미만 또는 초과하여 첨가될 경우, 충치 유발균에 대한 생육저해효과를 떨어뜨릴 수 있으므로, 설정된 중량 비율로 배합되는 것이 적절하다.The composition used in the present invention is characterized in that it contains schisandra chinensis in a weight ratio of 10:1 to 30:1, and preferably, schisandra chinensis is blended in a weight ratio of 18:1. When the Schisandra chinensis extract to the banana extract is added in less than or in excess of a set weight ratio, it may lower the growth-inhibiting effect on tooth decay-causing bacteria, so it is appropriate to be blended in a set weight ratio.
또한 본 발명의 오미자는 씨앗을 포함한 오미자 과육의 효소를 함유하고 있어 씨앗이 가지고 있는 맛과 영양을 그대로 함유 할 수 있다.In addition, since the Schisandra chinensis of the present invention contains enzymes of the flesh of Schisandra chinensis including seeds, it can contain the taste and nutrition of the seeds as they are.
상기 오미자 추출물은 스트렙토코커스 뮤탄스(streptococcus mutans), 스트렙토코커스 상기스(streptococcus sanguis), 스트렙토코쿠스 상귀니스(streptococcussanguinis), 스트렙토코쿠스 살리바리스 종 썰모필스(streptococcus salivaris subsp. thermophils), 포르피로모나스 긴기발리스(porphyromonas gingivalis) 및 칸디다 알비칸스(candida albicans)로 이루어진 군에서 선택된 하나 이상에 항균 효과가 있는 것을 특징으로 한다.The Schisandra chinensis extract is streptococcus mutans, streptococcus sanguis, streptococcus sanguinis, streptococcus salivaris sp. Monas gingivalis (porphyromonas gingivalis) and Candida albicans (candida albicans) is characterized by having an antibacterial effect on at least one selected from the group consisting of.
또한, 본 발명의 바나나 추출물은 스트렙토코커스 뮤탄스(streptococcus mutans), 스트렙토코커스 상기스(streptococcus sanguis), 스트렙토코쿠스 상귀니스(streptococcussanguinis), 스트렙토코쿠스 살리바리스 종 썰모필스(streptococcus salivaris subsp. thermophils), 포르피로모나스 긴기발리스(porphyromonas gingivalis)를 포함하는 군에서 선택된 하나 이상에 균주에 향균 효과가 있는 것을 특징으로 한다.In addition, the banana extract of the present invention includes streptococcus mutans, streptococcus sanguis, streptococcus sanguinis, streptococcus salivaris subsp. thermophils thermophils. ), Porphyromonas gingivalis (porphyromonas gingivalis) is characterized in that it has an antibacterial effect on one or more strains selected from the group.
본 발명의 따른 조성물의 예는 치약, 가글링 제품, 껌, 젤리, 구강 스프레이, 구강용 연고, 구강세정제 및 구강 청정제와 같은 구강용 제품 등이 있다. 본 발명의 조성물로 제조되는 각 구강용 제품의 구체적인 조성은 그것이 속하는 기술분야의 통상의 전문가에 의해 어렵지 않게 결정될 수 있다.Examples of compositions according to the present invention include oral products such as toothpaste, gargling products, gums, jellies, oral sprays, oral ointments, mouthwashes and mouthwashes. The specific composition of each oral product made from the composition of the present invention can be determined without difficulty by a person skilled in the art to which it belongs.
또한, 본 발명의 오미자 및 바나나 추출물은 액상과 고상형태로 이용될 수 있으며, 고형 분말로 조제할 경우, 곡류분말, 곡류효소, 자일리톨 결정 및 올리고당 분말과 함께 조제될 수 있다. 상기의 방법은 분말의 분산성 및 구강용해성이 증대되어, 이용자는 오미자 및 바나나 추출물이 포함된 고형 분말이 물 없이 섭취하더라도 구강 내에서 뭉침현상 없이 음용할 수 있다.In addition, the Schisandra chinensis and banana extract of the present invention may be used in liquid and solid forms, and when prepared as a solid powder, may be prepared together with grain powder, grain enzyme, xylitol crystal and oligosaccharide powder. The above method increases the dispersibility and oral solubility of the powder, so that the user can drink the solid powder containing Schisandra chinensis and banana extract without water in the oral cavity without clumping.
또한, 본 발명의 오미자 및 바나나 추출물의 추출에 있어서, (a) 박하유, 녹양박하유, 아니스유, 올스파이스유, 카르다몬유, 카시아유, 계피유, 감귤류유, 정향유, 고수유, 유칼리유, 회향유, 육두구유, 소엽유, 라벤더유, 라반딘유, 바위앵도유 등 같은 필수유, (b) 과일 향미제(예를 들어, 딸기, 멜론, 과일혼합물, 감귤류, 파인애플, 투티과일, 체리, 사과, 배, 포도 등), 꽃향미제(예를들어, 카네이션, 히아신스, 치자나무꽃, 독일은방울꽃, 라일락, 쟈스민, 장미, 제비꽃 등) 같은 향미제 화합물, (c) 리모넨, 시네올, 멘톨, 리날롤, 아네톨, 유게놀, 멘톤, 카르본, 살리실산 메틸, 신남알데히드 등 같은 향미제 화학제품을 첨가하고, 것들로부터 하부층을 수집함으로써 오미자 특유의 신맛과 독특한 맛을 차폐하여 식음자의 기호를 증진 시킬 수 있다.In addition, in the extraction of the Schisandra chinensis and banana extract of the present invention, (a) mentha oil, green spearmint oil, anise oil, allspice oil, cardamom oil, cassia oil, cinnamon oil, citrus oil, clove oil, coriander oil, eucalyptus oil, fennel oil Essential oils such as nutmeg oil, lobular oil, lavender oil, labandin oil, rock cherry oil, etc., (b) fruit flavoring agents (for example, strawberry, melon, fruit mixture, citrus fruits, pineapple, tutifruit, cherry, apple, Pears, grapes, etc.), flavoring compounds such as flower flavors (e.g. carnation, hyacinth, gardenia flower, german lily of the valley, lilac, jasmine, rose, violet, etc.), (c) limonene, cineol, menthol, li Flavoring chemicals such as nalol, anetol, eugenol, menthone, carbon, methyl salicylate, cinnamic aldehyde, etc. are added, and by collecting the lower layer from them, the acidity and unique taste of Schisandra are masked to enhance the taste of food and drink. I can.
또한, 본 발명의 오미자 및 바나나 추출물은 감미성 재료와 함께 배합되어, 젤리, 초콜릿, 캔디, 아이스크림 등과 같은 기호성 식품에 이용됨으로써, 비교적 장시간 입안에 잔류하는 고형식품을 섭취하더라도, 본 발명의 조성물에 의해 충치 유발균의 생육을 저해시킬 수 있는 효과가 있다.In addition, the Schisandra chinensis and banana extract of the present invention are blended with sweet ingredients and used in palatable foods such as jelly, chocolate, candy, ice cream, etc., so that even if solid foods remaining in the mouth for a relatively long time are ingested, the composition of the present invention As a result, there is an effect that can inhibit the growth of tooth decay-causing bacteria.
또한, 충치유발균이 구강내 당분을 이용하여 세포외로 글루칸이라는 끈적한 다당류를 분비하면 이 다당류에 의해 균체들이 서로 엉겨붙어 플라그를 형성하게되고, 이는 충치발생의 또 다른 원인이 된다. 따라서, 본 발명의 오미자 및 바나나 추출물은 플라그 형성을 억제시킴으로써, 충치를 효과적으로 예방할 수 있는 효과가있다.In addition, when the caries-causing bacteria secrete a sticky polysaccharide called glucan out of the cells using sugar in the oral cavity, the cells are entangled with each other to form plaque by the polysaccharide, which is another cause of tooth decay. Therefore, the Schisandra chinensis and banana extract of the present invention has an effect of effectively preventing tooth decay by inhibiting plaque formation.
본 발명의 오미자와 바나나 추출물을 이용한 구강질환 예방 또는 치료용 조성물에 의한 충치원인균 생육저해 시험 방법은 다음과 같다.A method for testing the growth inhibition of caries-causing bacteria by the composition for preventing or treating oral diseases using the Schisandra chinensis extract of the present invention is as follows.
■ 시험예1. ■ Test Example 1. 바나나 추출물에 의한 향균성 평가.Antibacterial evaluation by banana extract.
1) 실험방법1) Experiment method
본 발명은 바나나 추출물이 치주질환 원인 균에 대한 향균 효과가 있는지를 조사하였다. 그 후, 하기 표1의 균주를 동결건조하여 BHI 액체배지에 현탁한 후, 37℃에서 24시간 배양하여 균을 활성화시킨 다음 다시 BHI 고체배지에 도말 후 24시간동안 배양하였다. 디스크 검사법을 이용하여, 향균성을 평가하였으며, 50% 에탄올을 이용하여 90℃에서 추출한 바나나 추출물은 각각 0.5, 1, 2 mg/disc 농도로 처리하였고, 대조군은 5% 페놀용액과, BHI액체배지를 이용하여 실험을 진행하였다. 이에 최적 배양조건에서 24시간 배양한 후 생육저지환의 크기(mm)를측정하였고, 이에 기초하여 항균활성을 검증하였으며, 이를 하기 표2에 나타내었다.The present invention investigated whether the banana extract has an antibacterial effect on the bacteria causing periodontal disease. Thereafter, the strains of Table 1 below were lyophilized and suspended in a BHI liquid medium, cultured at 37° C. for 24 hours to activate the bacteria, and then spread on BHI solid medium and cultured for 24 hours. Antibacterial properties were evaluated using a disk test method, and the banana extract extracted at 90°C using 50% ethanol was treated at a concentration of 0.5, 1, and 2 mg/disc, respectively, and the control group was 5% phenol solution and BHI liquid medium. The experiment was carried out using. Accordingly, after culturing for 24 hours under optimal culture conditions, the size (mm) of the growth inhibition ring was measured, and the antibacterial activity was verified based on this, and it is shown in Table 2 below.
(Streptococcus mutans)Streptococcus mutans
(Streptococcus mutans)
(Streptococcus sanguis)Streptococcus Sagittarius
(Streptococcus sanguis)
(Streptococcus sanguinis)Streptococcus Sangwiness
(Streptococcus sanguinis)
(Porphyromonas gingivalis)Porphyromonas Gingivalis
(Porphyromonas gingivalis)
저지환
(mm)Growth
Jijihwan
(mm)
(Streptococcus mutans)Streptococcus mutans
(Streptococcus mutans)
(Streptococcus sanguis)Streptococcus Sagittarius
(Streptococcus sanguis)
(Streptococcus sanguinis)Streptococcus Sangwiness
(Streptococcus sanguinis)
(Porphyromonas gingivalis)Porphyromonas Gingivalis
(Porphyromonas gingivalis)
2) 실험결과2) Experiment result
상기 표 2에 나타낸 바와 같이, 바나나 추출물의 농도가 증가함에 따라 구강 내 치주질환 유발 균주(Streptococcus mutans, Streptococcus sanguis, Streptococcus sanguinis, Porphyromonas gingivalis) 에 대한 생육저지환크기역시 증가하는 것으로 조사되어 항균 효과가 있는 것을 확인할 수 있었다. 이는 바나나 추출물에 다량 함유된 탄닌 성분이 미생물 세포벽의 단백질과 반응하여 미생물의 효소활성이 저해되어 항균효과를 나타내는 것으로 추측된다.As shown in Table 2, as the concentration of the banana extract increases, the size of the growth inhibition against oral periodontal disease-causing strains (Streptococcus mutans, Streptococcus sanguis, Streptococcus sanguinis, Porphyromonas gingivalis) was also investigated to increase. I could confirm that there is. It is presumed that the tannin component contained in the banana extract reacts with the protein of the microbial cell wall, thereby inhibiting the enzyme activity of the microbe, resulting in an antibacterial effect.
■ 시험예2. ■ Test Example 2. 오미자 추출물에 의한 향균성 평가.Antibacterial evaluation by Schisandra chinensis extract.
1) 실험방법1) Experiment method
오미자 추출물에 대한 향균성을 평가하기 위하여, 스트렙코커스 뮤탄스(Streptococos mutans)를 사용하여 측정한다. 상기 균주는 스트렙코커스 뮤탄스(Streptococcus mutans) ATCC 25175로 Brain heart infusion(BHI, Difco, USA) 액체배지에 1-2차 계대배양 후 같은 배지에 식균하여 37℃의 항온기에서 24시간 배양하여 사용하였다. 50% 에탄올을 이용하여 90℃에서 추출한 오미자 추출물은 각각 0.5, 1, 2 mg/mL 농도로 처리함으로써, 오미자 추출물의 농도에 따른 향균성 평가를 진행하였다. 또한, 오미자 추출물 대신 증류수를 첨가하여 대조군을 제조하였고, 가글제품에 적용되는 성분으로서, CHX(chlorohexidine)성분을 첨가하여 오미자 추출물의 향균력을 비교하였다.In order to evaluate the antibacterial property of Schisandra chinensis extract, it is measured using Streptococos mutans. The strain was inoculated in the same medium after 1-2 passages in a brain heart infusion (BHI, Difco, USA) liquid medium with Streptococcus mutans ATCC 25175, and cultured for 24 hours in an incubator at 37°C. . Schisandra chinensis extract extracted at 90° C. using 50% ethanol was treated at a concentration of 0.5, 1, and 2 mg/mL, respectively, to evaluate antibacterial properties according to the concentration of Schisandra chinensis extract. In addition, distilled water was added instead of Schisandra chinensis extract to prepare a control group, and as a component applied to gargle products, CHX (chlorohexidine) component was added to compare the antibacterial power of Schisandra chinensis extract.
2) 실험결과2) Experiment result
도1을 참고하면, 2mg/mL 농도의 오미자 추출물은 대조군 보다 약 30%이상 치아균의 생육을 억제시켰으며, 0.5mg/mL, 1.0mg/mL 및 4.0mg/mL 농도의 오미자 추출물보다 구강 내 충치유발 균에 대해 현저한 향균 효과를 보였음을 확인 할 수 있다. Referring to FIG. 1, the Schisandra chinensis extract at a concentration of 2mg/mL inhibited the growth of tooth bacteria by about 30% or more than the control group, and was oral than the Schisandra chinensis extract at concentrations of 0.5mg/mL, 1.0mg/mL, and 4.0mg/mL. It can be confirmed that it showed a remarkable antibacterial effect against the bacteria that cause tooth decay.
■ 시험예3. ■ Test Example 3. 오미자와 바나나 혼합 추출물을 이용한 충치균의 향균기능성 평가.Evaluation of antibacterial function of caries bacteria using mixed extract of Schisandra chinensis and banana.
1) 실험방법1) Experiment method
본 발명의 충치균에 대한 항균력 기능성 시험은 스트렙코커스 뮤탄스(Streptococos mutans)를 사용하여 측정한다. 상기 균주는 스트렙코커스 뮤탄스(Streptococcus mutans) ATCC 25175로 Brain heart infusion(BHI, Difco, USA) 액체배지에 1-2차 계대배양 후 같은 배지에 식균하여 37℃의 항온기에서 24시간 배양하여 사용하였다. 오미자 및 바나나를 건조시켜 분쇄한 후, 50% 에탄올을 이용하여 90℃에서 오미자 추출물, 오미자 및 바나나 추출물을 수득하였다. 그 후, 오미자 및 바나나 추출물의 향균력 기능성 평가를 시험하기 위하여, 1%의 glucose가 들어 있는 BHI 액체배지에 오미자추출물, 오미자 및 바나나 추출물을 첨가한 후 균을 1x CFU/mL가 되도록 접종하였다. 설정온도 37℃의 항온기에서 24시간 배양한 후 BHI 액체배지를 기준으로 ELISA reader(Molecular Devices CO., CF., U.S.A)를 이용하여 550 nm에서 흡광도를 측정하였다. 또한, 대조군은 시료용액 대신 증류수를 첨가하였고, 하기의 제조방법에 따라 비교예 및 실시예를 제조하여 실험을 진행하였다.The functional test for antibacterial activity against tooth decay according to the present invention is measured using Streptococos mutans. The strain was inoculated in the same medium after 1-2 passages in a brain heart infusion (BHI, Difco, USA) liquid medium with Streptococcus mutans ATCC 25175, and cultured in a constant temperature of 37°C for 24 hours. . After drying and pulverizing Schisandra chinensis and banana, Schisandra chinensis extract, Schisandra chinensis and banana extract were obtained at 90° C. using 50% ethanol. Thereafter, in order to test the antibacterial function evaluation of the Schisandra chinensis and banana extract, the bacteria were 1x after adding Schisandra chinensis extract, Schisandra chinensis and banana extract to BHI liquid medium containing 1% glucose. It was inoculated so that it might become CFU/mL. After incubating for 24 hours in an incubator at a set temperature of 37°C, absorbance was measured at 550 nm using an ELISA reader (Molecular Devices CO., CF., USA) based on a BHI liquid medium. In addition, as a control group, distilled water was added instead of the sample solution, and Comparative Examples and Examples were prepared according to the following preparation method to conduct the experiment.
(배합 중량비 10:1)-Schisandra chinensis extract: Banana extract
(Mixed weight ratio 10:1)
(배합 중량비 18:1)-Schisandra chinensis extract: Banana extract
(Mixed weight ratio 18:1)
(배합 중량비 30:1)-Schisandra chinensis extract: Banana extract
(Mixed weight ratio 30:1)
2) 실험결과2) Experiment result
도 2에 의하면, 오미자와 바나나 추출물의 배합 중량비가 18:1인 실시예2는 설정된 배합비(10:1 내지 30:1)의 하한치 미만과 상한치 초과인 실시예 1 내지 실시예3에 비하여 충치유발균주에 생육을 억제하며, 비교예1에 비해 균주의 활성을 효과적으로 저해했음을 알 수 있다. 이에 따라, 오미자와 바나나 추출물을 18:1로 배합함으로써, 충치유발균에 대해 현저한 향균력을 가지는 조성물을 제공하는 효과가 있다.According to FIG. 2, Example 2 in which the blending weight ratio of Schisandra chinensis extract is 18:1 causes tooth decay compared to Examples 1 to 3 in which the lower limit and the upper limit of the set blending ratio (10:1 to 30:1) are less than It can be seen that it inhibits the growth of the strain and effectively inhibited the activity of the strain compared to Comparative Example 1. Accordingly, there is an effect of providing a composition having remarkable antibacterial power against tooth decay-causing bacteria by blending the Schisandra chinensis extract at 18:1.
■ 시험예3. ■ Test Example 3. 오미자와 바나나 혼합 추출물에 대한 플라그 형성 억제시험.Plaque formation inhibition test for mixed extract of Schisandra chinensis and banana.
1) 실험방법1) Experiment method
상기 실시예 1 내지 실시예3 및 비교예1에 따른 오미자와 바나나 추출물에 대한 플라그 형성 억제시험을 실시하여, 이에 대한 결과를 하기의 표4에 기재하였다.Plaque formation inhibition tests were performed on the Schisandra chinensis extract according to Examples 1 to 3 and Comparative Example 1, and the results thereof are shown in Table 4 below.
플라그 형성 억제시험은 이중맹검법으로서, 피험자들이 시료의 구분이 가능하지 않도록 조절하여 시험을 실시하였다. 시험예 2에서, 플라그 형성 평점 기준은 하기와같다.The plaque formation inhibition test was a double-blind method, and the test was conducted by controlling so that subjects could not distinguish between samples. In Test Example 2, the criteria for the plaque formation score were as follows.
0: 프라그가 전혀 생성되지 않음0: no plaques are created
1: 치은연부에 점상으로 프라그가 형성된 경우1: If plaque is formed in the form of dots on the gingival edge
2: 치경부에 환상으로 1㎜ 이하의 프라그가 형성된 경우2: When plaques of 1 mm or less are formed in an annular shape in the cervical area
3: 치경부측 1/3미만의 치면에 환상으로 1㎜ 이상의 프라그가 형성된 경우3: When plaques of 1 mm or more are formed annularly on the tooth surface of less than 1/3 of the cervical side
4: 치경부측 2/3미만의 치면에 프라그가 형성된 경우4: When plaque is formed on the tooth surface less than 2/3 of the cervical side
5: 치경부측 2/3이상의 치면에 프라그가 형성된 경우5: If plaque is formed on the tooth surface more than 2/3 of the cervical side
2) 실험결과2) Experiment result
표4에서 알 수 있는 바와 같이, 실시예2는 실시예1, 실시예3 내지 비교예1에 비해 플라그 형성이 현저히 억제되어 개선되었음을 알 수 있다. 따라서, 실시예2에 따른 오미자 및 바나나 추출물은 플라그 형성에 억제에 효과를 가짐을 알 수 있다.As can be seen from Table 4, it can be seen that Example 2 significantly suppressed plaque formation compared to Examples 1 and 3 to 1 and thus improved. Therefore, it can be seen that the extract of Schisandra chinensis and banana according to Example 2 has an effect on inhibiting plaque formation.
■ 시험예4. ■ Test Example 4. 오미자와 바나나 혼합 추출물에 대한 구강질환 억제시험.Oral disease inhibition test for mixed extract of Schisandra chinensis and banana.
1) 실험방법1) Experiment method
상기 실시예 1 내지 실시예3 및 비교예1에 따른 오미자와 바나나 추출물에 대한 플라그 형성 억제시험을 실시하여, 이에 대한 결과를 하기의 표5에 기재하였다.Plaque formation inhibition tests were performed on the extracts of Schisandra chinensis according to Examples 1 to 3 and Comparative Example 1, and the results are shown in Table 5 below.
구강질환 억제시험은 이중맹검법으로서, 피험자들이 시료의 구분이 가능하지 않도록 조절하여 시험을 실시하였다. 시험예 4에서, 구강질환 평점 기준은 하기와같다.The oral disease inhibition test was a double-blind method, and the test was conducted by controlling the subjects so that the samples could not be distinguished. In Test Example 4, the oral disease rating criteria are as follows.
0: 정상치주0: normal periodontal
1: 치주 주변 경미한 염증, 색조변화, 가벼운 부종1: Slight inflammation around the periodontal, color change, mild edema
2: 중증염증, 부종, 치주의 색조변화 및 치주탐침에 의한 경한 자극으로 출혈이 있는 경우2: In case of bleeding due to severe inflammation, swelling, change in color tone of periodontal and mild irritation by periodontal probe
3: 심한염증, 부종, 궤양이 존재하며 자연적으로 출혈이 있는 경우3: Severe inflammation, swelling, ulcers are present, and bleeding occurs naturally
구강질환 지수 = 총평점/평점치면수Oral disease index = total score/number of planes scored
2) 실험결과2) Experiment result
표5에서 알 수 있는 바와 같이, 실시예2는 실시예1 내지 실시예3에 비해 1개월 후, 2개월 후 구강질환(치주 및 잇몸 염증)이 억제되었고, 비교예 1의 경우에 비해 개선 지수가 현저히 높게 나타났음을 알 수 있다. As can be seen in Table 5, in Example 2, oral diseases (periodontal and gum inflammation) were suppressed after 1 month and 2 months compared to Examples 1 to 3, and improvement index compared to Comparative Example 1. It can be seen that is significantly higher.
■ 시험예5. 고형식품 제조■ Test Example 5. Solid food manufacturing
[실시예4] 오미자 및 바나나 추출물을 함유하는 아이스크림 제조 [Example 4] Preparation of ice cream containing Schisandra chinensis and banana extract
상기 실시예2에서 얻은 오미자 및 바나나 추출물을 이용하여 하기의 성분 및 함량에 따라서 아이스크림을 제조하였다.Using the Schisandra chinensis and banana extract obtained in Example 2, ice cream was prepared according to the following ingredients and contents.
(실시예2)Schisandra and Banana Extract
(Example 2)
[실시예5] 오미자 및 바나나 추출물을 함유하는 츄잉껌 제조 [Example 5] Preparation of chewing gum containing Schisandra chinensis and banana extract
상기 실시예2에서 얻은 오미자 및 바나나 추출물을 이용하여 하기의 성분 및 함량에 따라서 츄잉껌을 제조하였다.Using the Schisandra chinensis and banana extract obtained in Example 2, a chewing gum was prepared according to the following components and contents.
(실시예2)Schisandra and Banana Extract
(Example 2)
[실시예6] 오미자 및 바나나 추출물을 함유하는 젤리제조 [Example 6] Preparation of Jelly Containing Schisandra chinensis and Banana Extract
상기 실시예2에서 얻은 오미자 및 바나나 추출물을 이용하여 하기의 성분 및 함량에 따라서 젤리를 제조하였다.Using the Schisandra chinensis and banana extract obtained in Example 2, jelly was prepared according to the following components and contents.
(실시예2)Schisandra and Banana Extract
(Example 2)
[실시예7] 오미자 및 바나나 추출물을 함유하는 캔디 제조 [Example 7] Preparation of candy containing Schisandra chinensis and banana extract
상기 실시예2에서 얻은 오미자 및 바나나 추출물을 이용하여 하기의 성분 및 함량에 따라서 캔디를 제조하였다.Using the Schisandra chinensis and banana extract obtained in Example 2, candy was prepared according to the following components and contents.
(실시예2)Schisandra and Banana Extract
(Example 2)
[실시예8] 오미자와 바나나 추출물을 함유하는 초콜릿 [Example 8] Chocolate Containing Omizawa Banana Extract
상기 실시예2에서 얻은 오미자 및 바나나 추출물을 이용하여 하기의 성분 및 함량에 따라서 젤리를 제조하였다.Using the Schisandra chinensis and banana extract obtained in Example 2, jelly was prepared according to the following components and contents.
(실시예2)Schisandra and Banana Extract
(Example 2)
Claims (6)
상기 바나나 추출물은 스트렙토코커스 뮤탄스(streptococcus mutans)에 의해 유발되는 충치와 스트렙토코커스 상기스(streptococcus sanguis), 스트렙토코쿠스 상귀니스(streptococcussanguinis), 포르피로모나스 긴기발리스(porphyromonas gingivalis)로 이루어진 군에서 선택된 하나 이상에 균에 의해 유발되는 치주질환을 예방 또는 치료하는 것을 특징으로 하는 오미자 추출물과 바나나 추출물을 이용한 충치와 치주질환 예방 또는 치료용 조성물.
Schisandra chinensis extract and banana extract are contained in a weight ratio of 18:1,
The banana extract is from the group consisting of tooth decay caused by streptococcus mutans and streptococcus sanguis, streptococcus sanguinis, and porphyromonas gingivalis. A composition for preventing or treating tooth decay and periodontal disease using Schisandra chinensis extract and a banana extract, characterized in that preventing or treating periodontal disease caused by bacteria in one or more selected.
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Antibacterial activity of methanol extract of mauli banana (Musa sp) stems against Streptococcus mutans, Journal of Dentomaxillofacial Science, 12(3), 148-151(2013.10.30.) 1부.* |
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