KR102120513B1 - 이미다조피리딘 화합물 및 이의 용도 - Google Patents

이미다조피리딘 화합물 및 이의 용도 Download PDF

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KR102120513B1
KR102120513B1 KR1020157023171A KR20157023171A KR102120513B1 KR 102120513 B1 KR102120513 B1 KR 102120513B1 KR 1020157023171 A KR1020157023171 A KR 1020157023171A KR 20157023171 A KR20157023171 A KR 20157023171A KR 102120513 B1 KR102120513 B1 KR 102120513B1
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methyl
formula
salt
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KR20150123812A (ko
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크리스토프 부온
루이-다비드 캉탱
윤-진 후
수에홍 루오
미로슬라브 예지 토마스체브스키
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네오메드 인스티튜트
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Assigned to 벨루스 헬스 코프 인크. reassignment 벨루스 헬스 코프 인크. 권리의 전부이전등록 Assignors: 네오메드 인스티튜트
Assigned to 14245563 캐나다 인크. reassignment 14245563 캐나다 인크. 권리의 전부이전등록 Assignors: 벨루스 헬스 인크.
Assigned to 벨루스 헬스 인크. reassignment 벨루스 헬스 인크. 권리의 전부이전등록 Assignors: 벨루스 헬스 코프 인크.
Assigned to 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 3) 리미티드 reassignment 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 3) 리미티드 권리의 전부이전등록 Assignors: 아이디 바이오메디컬 코포레이션 오브 퀘벡
Assigned to 아이디 바이오메디컬 코포레이션 오브 퀘벡 reassignment 아이디 바이오메디컬 코포레이션 오브 퀘벡 권리의 전부이전등록 Assignors: 14245563 캐나다 인크.
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020157023171A 2013-01-31 2014-01-31 이미다조피리딘 화합물 및 이의 용도 Active KR102120513B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759123P 2013-01-31 2013-01-31
US61/759,123 2013-01-31
PCT/CA2014/050062 WO2014117274A1 (en) 2013-01-31 2014-01-31 Imidazopyridine compounds and uses thereof

Publications (2)

Publication Number Publication Date
KR20150123812A KR20150123812A (ko) 2015-11-04
KR102120513B1 true KR102120513B1 (ko) 2020-06-08

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Country Status (17)

Country Link
US (9) US9598409B2 (https=)
EP (3) EP3998267A1 (https=)
JP (1) JP6373280B2 (https=)
KR (1) KR102120513B1 (https=)
CN (2) CN107485612B (https=)
AU (1) AU2014211962B2 (https=)
BR (1) BR112015018317B1 (https=)
CA (1) CA2898665C (https=)
DK (2) DK3381917T3 (https=)
ES (2) ES2674087T3 (https=)
MX (1) MX372934B (https=)
NO (1) NO2910833T3 (https=)
PL (2) PL3381917T3 (https=)
PT (2) PT2951177T (https=)
RU (1) RU2656593C2 (https=)
TR (1) TR201807602T4 (https=)
WO (1) WO2014117274A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200092938A (ko) * 2017-09-18 2020-08-04 벨루스 헬스 코프 인크. 선택적 p2x3 조정제

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* Cited by examiner, † Cited by third party
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DK3381917T3 (da) * 2013-01-31 2021-10-18 Bellus Health Cough Inc Imidazopyridinforbindelser og anvendelser deraf
EP3230281B1 (en) 2014-12-09 2021-05-26 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
US9907795B2 (en) * 2016-01-08 2018-03-06 Nerre Therapeutics Limited Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents
RU2019112740A (ru) 2016-09-30 2020-11-02 АСАНА БАЙОСАЙЕНСИЗ, ЭлЭлСи P2x3 и/или p2x2/3 соединения и способы
EP3339307A1 (en) * 2016-12-20 2018-06-27 Laboratorios del Dr. Esteve, S.A. Nitrogen containing bicyclic derivatives for treating pain and pain related conditions
ES2963702T3 (es) 2018-10-05 2024-04-01 Shionogi & Co Medicina para tratar la tos crónica
IL282087B2 (en) * 2018-10-10 2025-11-01 Bellus Health Cough Inc 4-(imidazo[1,2-a]pyridin-3-yl)-benzamide derivatives for treating pruritus
HRP20250864T1 (hr) 2018-11-13 2025-09-26 Glaxosmithkline Intellectual Property (No. 3) Limited Kristalni oblici p2x3 modulatora metil (s)‑2‑((2‑(2,6‑difluoro‑4‑(metilkarbamoil)fenil)‑7‑metilimidazo[1,2‑a] piridin‑3‑il)metil)morfolin‑4‑karboksilata
KR102797127B1 (ko) * 2018-12-29 2025-04-21 우한 크리에이터나 사이언스 앤드 테크놀로지 컴퍼니, 리미티드 헤테로고리계 화합물, 중간체, 이의 제조 방법 및 용도
JP7578602B2 (ja) * 2019-02-25 2024-11-06 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー３）、リミテッド Ｐ２ｘ３修飾薬での治療
CN112409331B (zh) * 2019-08-21 2024-02-20 上海翰森生物医药科技有限公司 杂环类衍生物抑制剂、其制备方法和应用
EP4103564A4 (en) * 2020-02-14 2024-05-01 GlaxoSmithKline Intellectual Property (No.3) Limited P2X3 MODULATORS
CN115427419B (zh) * 2020-02-14 2026-04-21 葛兰素史密斯克莱知识产权(第3号)有限公司 P2x3拮抗剂的制备
CN113549068B (zh) * 2020-04-24 2022-12-02 上海拓界生物医药科技有限公司 一类新型咪唑并吡啶化合物、其制备方法及其在医药上的应用
WO2021244634A1 (zh) * 2020-06-05 2021-12-09 武汉人福创新药物研发中心有限公司 咪唑并吡啶类化合物及其用途
CN114085220B (zh) * 2020-06-22 2023-06-16 上海海雁医药科技有限公司 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途
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CN113912601B (zh) * 2020-07-10 2023-06-06 上海拓界生物医药科技有限公司 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途
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