KR102117677B1 - The composition of triple salt disinfectant which improved solubility - Google Patents

Abstract

The present invention innovatively improves the solubility inadequate phenomenon, which is a problem of the existing three kinds of disinfectants, so that the disinfectant powder dissolves well in cold water in winter, solves the avoidance of the three kinds of disinfectants, increases demand, and dissolves well in water to prevent disinfection efficiency. In order to maximize the solubility, we intend to provide a composite composition of a three-salt disinfectant for livestock with improved solubility.

Description

The composition of triple salt disinfectant which improved solubility}

The present invention is a composite composition for the treatment of livestock epidemics such as avian influenza, and improved solubility for livestock trichloride, and more specifically, innovatively improves the solubility underabsorption problem, which is a problem of the existing trichloride, and disinfectant powder in cold water during winter. The present invention relates to a composite composition of a three-salt disinfectant for livestock with improved solubility that improves solubility and convenience in use by dissolving well.

Recently, avian influenza (Avian influenza) has been suffering from massive economic damage as it continues to develop in Korea. Avian influenza is an acute respiratory disease that infects birds, and is also called avian influenza. It is a viral disease that has a fatality rate of up to 100% when infected. In particular, avian influenza can be transmitted from animals to humans, so it is a very important public health disease, and most countries have established and implemented a quarantine policy under national responsibility. Avian influenza spreads to the poultry farm where chickens, ducks, etc. are contaminated by rodent animals such as humans, vehicles, rats, etc. It is reported that horizontal propagation (secondary propagation) is made through livestock-related vehicles such as feed vehicles.

Therefore, the Korean government also selected November to March as a special quarantine period for avian influenza during the winter season, and selected a site disinfection site as a regional unit. It is carried out.

Most of the disinfectants for livestock that are currently approved for the prevention of avian influenza are the three types of antiseptics, acidic agents, aldehydes, and sodium isocyanate disinfectants.

However, in Korea, avian influenza occurs mostly in winter, and due to the nature of the virus, as the temperature decreases, the activity of the virus becomes stronger. This is because under the sub-zero conditions, the disinfectant particles freeze when spraying the disinfectant, or the brown motion of the disinfectant particles contracts and the disinfecting effect is greatly reduced.

According to the results of the recent disinfection efficacy test of avian influenza virus according to the outdoor temperature conducted by the Veterinary Medical School, it can be seen that the disinfection effect is significantly lowered at less than half at minus 5 compared to image 4. In particular, in the case of acidic preparations with a combination of quaternary ammonium and organic or inorganic acids, the disinfecting effect of the avian influenza virus was significantly reduced under sub-zero conditions. It was found that the reduction of disinfection efficacy was small.

Therefore, the guidelines for disinfectants for the prevention of avian influenza produced by the Ministry of Agriculture, Food and Rural Affairs and the Ministry of Agriculture, Forestry and Livestock Quarantine and distributed to poultry livestock farms are sterilized by government-run base sterilization sites and livestock sterilized by farmers. In winter, it is recommended to use a sanitizer disinfectant.

The three kinds of salting agent is a livestock disinfectant containing potassium monopersulfate, and it is known as the most used disinfectant worldwide because of its excellent disinfecting power. However, the three kinds of salting agents are made of powder because of the nature of the oxidizing agent-based disinfecting agent that dissolves in water to generate generator oxygen, thereby exerting disinfecting power.

In particular, in the cold winter, disinfectant powder is not easily dissolved in cold water, and there is a problem such as clogging of the nipple of the high-pressure sprayer, and thus avoidance is caused by the sterilization manager and livestock farmers. During the recent quarantine surveillance of avian influenza, some municipalities had administrative measures, such as the use of acidic agents that are convenient to use due to the avoidance of the three types of agents, and exchange with the three types of agents with disciplinary action. In addition, in the research on the use of disinfecting drugs conducted by the parent university, some base disinfectants were not dissolved in water and precipitated under a disinfecting mixer, causing serious problems in the prevention of avian influenza.

In order to prevent the occurrence of avian influenza, which has become like an annual event in the winter, it is recommended to use three kinds of anti-oxidant-based disinfectants, which have a relatively small reduction in disinfecting efficacy, even under sub-zero conditions, in order to prevent them from occurring. Because it is made of powder because of the nature of the three kinds of salting agents, the three kinds of salting agents are not soluble in cold water.

Registered Patent Publication No. 10-1338873 Registered Patent Publication No. 10-1323982 Patent Publication No. 10-2012-0102372

Therefore, in order to solve the above problems, the present invention innovatively improves the solubility inadequate phenomenon, which is a problem of the existing three kinds of disinfectants, so that the disinfectant powder is well soluble in cold water in winter to solve the avoidance of the three kinds of salts. The objective is to provide a composite composition of a three-salt disinfectant for livestock with improved solubility to increase and dissolve well in water to maximize the prevention efficiency.

The technical means of the present invention for achieving the above object is a triple salt, citric acid, sulfamic acid, sodium chloride, sodium olefin sulfonate and As a composite composition comprising sodium metaphosphate, the composite composition has a compositional ratio of 45 to 65% by weight of tribasic salt, 15 to 23% by weight of citric acid, 3 to 6% by weight of sulfamic acid, and 1 to 2 of sodium chloride. It is characterized by consisting of weight%, 1 to 3% by weight of sodium olefin sulfonate and 1 to 35% by weight of sodium metaphosphate.

The present invention is made by including a triple salt, citric acid, sulfamic acid, sodium chloride, sodium olefin sulfonate and sodium metaphosphate It is a composite composition of a three-salt disinfectant for livestock with improved solubility, and innovatively improves the poor solubility, which is a problem of the existing three-salt disinfectant, so that the disinfectant powder dissolves well in cold water in winter, thereby avoiding the three-salt disinfectant. There is a very useful effect that can be solved to increase the demand and maximize disinfection efficiency by dissolving in water well.

Hereinafter, the present invention will be described more specifically.

The complex composition of the tri-salt disinfectant for livestock with improved solubility according to the present invention is a disinfecting component, tri-salt and organic acid for improving the solubility citric acid, sulfamic acid, tri-sodium disinfectant enhancer sodium chloride, surfactant for improving solubility, sodium olefin sulfonate and metaphosphoric acid It is composed of sodium. It improves the solubility, which is a problem of the existing disinfectant preparations, so that the disinfectant powder dissolves well in cold water in winter. Is to solve.

When describing each of the components of the composite composition, it is preferable that the disinfecting component, hematitis, is 45 to 65% by weight based on the total composition. At this time, if the tri-salt is less than 45% by weight, the disinfecting power is insufficient, and when it is 65% by weight or more, other constituents cannot be sufficiently used, which is not preferable.

The composition citric acid of the present invention is preferably used 15 to 23% by weight of the total composition, if the amount of citric acid is less than 15% by weight in the present invention, the solubility improvement effect is insufficient, and when it is 23% by weight or more, it is preferable to use it in excess. Can't.

It is preferable to use 3 to 6% by weight of the total composition of the sulfamic acid used in the present invention, when the amount of sulfamic in the present invention is 3% by weight or less, the solubility improving effect is insufficient, and when it is 6% by weight or more, it is excessive. Not recommended for use.

Sodium chloride in the composition of the present invention is preferably 1 to 2% by weight of the total composition, and less than 1% by weight is not preferable because the effect of improving the disinfecting power of the three types of salt is not desirable, and when it is more than 2% by weight, it is not preferable.

 The sodium olefin sulfonate used in the present invention is preferably used in an amount of 1 to 3% by weight of the total composition. In the present invention, when the amount of sodium olefin sulfonate is 1% by weight or less, the solubility improving effect is insufficient and 3% by weight In the above case, the manufacturing cost is higher than the solubility improvement, which is undesirable.

Among the composite compositions of the tri-salt disinfectant for livestock with improved solubility according to the present invention, the total weight percent of the tri-salt disinfectant complex composition is based on the sum of the weight percent of the disinfectant components used in both the disinfectant components and the solubility-improving agent and the tri-salt disinfectant enhancer. It is used as an excipient to be 100% by weight.

The present invention can be understood in more detail by the following comparative examples, examples and experimental examples, and the following examples are only intended to illustrate the invention and are not intended to produce the scope of the invention.

[Comparative Example 1]

A composite composition is prepared from the composition shown in Table 1 below.

ingredient weight Hepatitis 500 g Apple 150 g Sulfamic acid 50 g Sodium chloride 15 g Sodium dodecylbenzenesulfonate 165 g Sodium metaphosphate 120 g Total 1kg

The process of manufacturing the composite composition of [Table 1] is as follows.

The ingredients are sequentially added to the powder mixer, and then mixed for 30 minutes at a rate of 35 rpm to produce a small amount of packaging and packaging.

A composite composition is prepared from the composition shown in Table 2 below.

ingredient weight Hepatitis 500 g Citric acid 200 g Sodium chloride 15 g Sodium dodecylbenzenesulfonate 165 g Sodium metaphosphate 120 g Total 1kg

The process of manufacturing the composite composition of [Table 2] is as follows.

The ingredients are sequentially added to the powder mixer, and then mixed for 30 minutes at a rate of 35 rpm to produce a small amount of packaging and packaging.

A composite composition is prepared from the composition shown in Table 3 below.

ingredient weight Hepatitis 600 g Citric acid 100 g Sulfamic acid 50 g Sodium chloride 15 g Sodium dodecylbenzenesulfonate 165 g Sodium metaphosphate 70 g Total 1kg

The process of manufacturing the composite composition of [Table 3] is as follows.

The ingredients are sequentially added to the powder mixer, and then mixed for 30 minutes at a rate of 35 rpm to produce a small amount of packaging and packaging.

A composite composition is prepared from the composition shown in Table 4 below.

ingredient weight Hepatitis 500 g Citric acid 200 g Sodium chloride 15 g Sodium olefin sulfonate 15 g Sodium metaphosphate 220 g Total 1kg

The process of manufacturing the composite composition of [Table 4] is as follows.

The ingredients are sequentially added to the powder mixer, and then mixed for 30 minutes at a rate of 35 rpm to produce a small amount of packaging and packaging.

A composite composition is prepared from the composition shown in Table 5 below.

ingredient weight Hepatitis 600 g Citric acid 100 g Sulfamic acid 50 g Sodium chloride 15 g Sodium olefin sulfonate 15 g Sodium metaphosphate 220 g Total 1kg

The process of manufacturing the composite composition of [Table 5] is as follows.

The ingredients are sequentially added to the powder mixer, and then mixed for 30 minutes at a rate of 35 rpm to produce a small amount of packaging and packaging.

A composite composition is prepared from the composition shown in Table 6 below.

ingredient weight Hepatitis 600 g Citric acid 200 g Sulfamic acid 50 g Sodium chloride 15 g Sodium olefin sulfonate 15 g Sodium metaphosphate 120 g Total 1kg

The process of manufacturing the composite composition in [Table 6] is as follows.

The ingredients are sequentially added to the powder mixer, and then mixed for 30 minutes at a rate of 35 rpm to produce a small amount of packaging and packaging.

Kinds Combined composition of three kinds of disinfectant for livestock with improved solubility Comparative Example 1 Hematitis (50) + apple acid (15) + sulfamic acid (5) + sodium chloride (1.5) + sodium dodecylbenzenesulfonate (16.5) + sodium metaphosphate (12) Example 1 Hepatitis (50) + citric acid (20) + sodium chloride (1.5) + sodium dodecylbenzenesulfonate (16.5) + sodium metaphosphate (12) Example 2 Hematitis (60) + citric acid (20) + sulfamic acid (5) + sodium chloride (1.5) + sodium dodecylbenzenesulfonate (16.5) + sodium metaphosphate (7) Example 3 Hematitis (50) + citric acid (20) + sodium chloride (1.5) + sodium olefin sulfonate (1.5) + sodium metaphosphate (12) Example 4 Hematitis (60) + citric acid (10) + sulfamic acid (5) + sodium chloride (1.5) + sodium olefin sulfonate (1.5) + sodium metaphosphate (22) Example 5 Hepatitis (60) + citric acid (20) + sulfamic acid (5) + sodium chloride (1.5) + sodium olefin sulfonate (1.5) + sodium metaphosphate (12)

[Table 7] is the composition of the composite composition for the tri-salt disinfectant for livestock with improved solubility, and the number in '()' represents the weight percent by weight.

[Experimental Example 1]

1. Experimental method

In order to check the stability of the composite composition of Comparative Example 1 and Examples 1 to 5, each composition was hermetically packaged in silver foil (PET + PE + AL + PE + LLDPE) in units of 1 kg, and stored at room temperature for 0 months, After 3, 6, and 12 months, the content of the anomaly and disinfecting ingredient, hepatitis, was measured.

2. Experimental results

In Comparative Example 1 and the composite composition of each example, there was no change in properties, and the content of the disinfecting ingredient, hepatitis, was within the range of 90 to 110%, which was stable in all cases. Table 8 shows the results of the experiment.

Kinds Constellation Hepatitis content (%) At the start 3 months
after 6 months later 12 months later At the start 3 months later 6 months later 12 months later Comparative Example 1 White powder Change Change Change 100.3 100.4 100.3 100.2 Example 1 White powder Change Change Change 100.2 100.4 100.1 100.2 Example 2 White powder Change Change Change 100.5 100.1 100.5 100.3 Example 3 White powder Change Change Change 100.3 100.0 100.4 100.1 Example 4 White powder Change Change Change 100.1 100.3 100.2 100.0 Example 5 White powder Change Change Change 100.3 100.2 100.2 100.3

[Stability of Comparative Examples and Example Compositions]

[Experimental Example 2]

1. Experimental method

In order to measure the solubility of the composites of Comparative Examples 1 and 1 to 5, 24 beakers were filled with 1 liter of tap water, respectively, and then a water tank equipped with a temperature control device to maintain the temperature of the tap water at 10, 4, 0, minus 5 Each of the 6 beakers was immersed in each temperature, and then the tap water temperature was set to 10, 4, 0, and minus 5 respectively. To each beaker, Comparative Example 1 and Test Examples 1,2,3,4,5 10g were accurately weighed and stirred at 180 RPM for 3 minutes, and solubility was measured after 10 minutes.

2. Experimental results

The solubility test results for the composite composition of Comparative Example 1 and Examples are shown in Table 9 below.

Kinds Solubility in dilution of tap water 100 times 10 4 0 Subzero 5 Comparative Example 1 Great Good Inadequate Bad Example 1 Great Good Inadequate Bad Example 2 Great Good Inadequate Inadequate Example 3 Great Great Good Inadequate Example 4 Great Great Good Good Example 5 Great Great Great Great

[Solubility of Comparative Examples and Example Compositions]

[Experimental Example 3]

1. Experimental method

Comparative Example 1 and Comparative Examples 1 to 5 were compared and evaluated using MIC measurement in order to determine the disinfecting power in the presence of the organic matter. After inoculating 0.2 mL of E. coli ATCC 25922 with 100 mL of Nutrition agar and incubating for 24 hours, a test piece with a diameter of 8 mm and a thickness of 1.5 mm was placed on the medium, and as a test solution, yeast extract was extracted from each of the above-mentioned compositions. The 5% organic diluent prepared by inoculation was inoculated 50 to each test piece, put into the incubator again, and cultured for 24 hours, and then the average diameter of the bacterial growth-lowering ring was measured.

2. Experimental results

Comparative Example 1 and the disinfection power experiment results of the composite compositions of the Examples are shown in Table 10 below.

Kinds Average diameter of germ-developed low rings (mm) Comparative Example 1 11.5 Example 1 11.7 Example 2 12.1 Example 3 11.6 Example 4 12.4 Example 5 12.8

[Disinfecting power in the presence of organic matter in Comparative Examples and Example Compositions]

As shown in the above experimental examples, the composite composition of the trichloride disinfectant for livestock with improved solubility according to the present invention is triple salt, citric acid, sulfamic acid, and sodium chloride. , It is formed by mixing sodium olefin sulfonate and sodium metaphosphate in a certain ratio, and innovatively improves the solubility underabsorption problem, which is a problem of the existing three kinds of disinfectants, disinfectant powder in cold water in winter. It is an invention with very high industrial applicability because it can dissolve well and solve the avoidance phenomenon of the three kinds of salting agent to increase the demand, and to dissolve well in water to maximize the prevention efficiency.

Claims (2)

As a complex composition containing triple salt, citric acid, sulfamic acid, sodium chloride, sodium olefin sulfonate and sodium metaphosphate ,
The composition of the composition is 45 to 65% by weight of the composition ratio of the components, 15 to 23% by weight of citric acid, 3 to 6% by weight of sulfamic acid, 1 to 2% by weight of sodium chloride, 1 to 3% by weight of sodium olefin sulfonate and metaphosphoric acid A complex composition of a three-salt disinfectant for livestock with improved solubility, characterized by consisting of 1 to 35% by weight of sodium.
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