KR102097992B1 - 신규한 중증열성혈소판감소증후군 바이러스 - Google Patents
신규한 중증열성혈소판감소증후군 바이러스 Download PDFInfo
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- KR102097992B1 KR102097992B1 KR1020180078507A KR20180078507A KR102097992B1 KR 102097992 B1 KR102097992 B1 KR 102097992B1 KR 1020180078507 A KR1020180078507 A KR 1020180078507A KR 20180078507 A KR20180078507 A KR 20180078507A KR 102097992 B1 KR102097992 B1 KR 102097992B1
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Abstract
본 발명은 신규한 유전형의 중증열성혈소판감소증후군 바이러스 및 이의 면역원성 조성물로서의 용도에 관한 것으로, 본 발명의 바이러스들은 중증열성 혈소판 감소증 바이러스들은 각각 계통학적으로 A형 및 F형에 속하나, 종래의 유전자형의 혈소판 감소증 바이러스들과 유전적으로 상이한 신규한 바이러스들이므로, 어느 특정 유전형의 바이러스만으로는 제한된 방어능을 보이는 백신의 특성상, 본 발명의 신규한 바이러스들을 SFTSV에 대한 교차 면역원성이 우수한 백신으로서 유용하게 이용할 수 있다.
Description
본 발명은 신규한 중증열성혈소판감소증후군 바이러스 및 이의 면역원성 조성물로서의 용도에 관한 것이다.
중증열성혈소판감소증후군 (Severe fever with thrombocytopenia syndrome, SFTS)는 고열, 구토, 설사, 혈소판감소, 백혈구감소 및 다발성 장기부전과 같은 증상을 동반하며, 치사율이 6-30%에 이르는 심각한 질환이다 (Yu XJ et al., N. Engl. J. Med. 2011; 364:1523-32; Ding F et al Clin Infect Dis 2013; 56: 1682-3).
SFTS의 원인병원체는 SFTSV (severe fever thrombocytopenia syndrome virus, 중증열성 혈소판 감소증 바이러스) (HB29 스트레인)이며, 버냐바이러스과(Bunyaviridae)에 속한다. 버냐바이러스과는 세개의 분절을 포함한 음성가닥(negative-strand) RNA 바이러스인데, 오르토버냐바이러스(Orthobunyavirus), 한타바이러스(Hantavirus), 나이로바이러스(Nairovirus), 플레보바이러스(Phlebovirus), 토스포바이러스(Tospovirus)를 포함하는 다섯개의 속(genus)로 이루어져 있다. SFTSV는 플레보바이러스 속(Phlebovirus genus)에 속하며, 여기에 리프트밸리열바이러스(Rift valley fever virus) 등이 속해있다. SFTSV는 2011년에 중국에서 최초로 보고되었고 (Yu XJ et al. ibid), 중국 뿐 아니라 한국 그리고 일본에서도 지속적으로 발병하고 있는 신 변종 바이러스이다. SFTSV는 지름이 80-100 nm인 공 모양의 바이러스이다. 이 바이러스는 single-stranded negative sense RNA segment인 큰 분절(large (L) segment), 중간 분절(medium (M) segment) 및 작은 분절(small (S) segment) 이렇게 3개의 유전자를 지니고 있다.
SFTS 바이러스는 작은소참진드기(Haemaphysalis longicornis)를 매개체로 하는 것으로, 상기 진드기는 한국에도 널리 퍼져 있는 것으로 알려져 있다 (Chae JS et al. J Vet Sci 2008; 9: 285-93; Kim CM et al. Appl Environ Microbiol 2006; 72: 5766-76). SFTS 바이러스의 혈청전환 및 바이러스혈증이 염소, 양, 소, 돼지 및 개와 같은 사육동물에서 발견되었으며, 이러한 동물도 SFTS 바이러스가 퍼진 지역에서 중간 매개체로 작용하는 것으로 여겨지고 있다 (Zhao L et al. Emerg Infect Dis 2013; 18: 963-5; Niu G et al. Emerg Infect Dis 2013; 19: 756-63). 환자의 혈액에는 SFTSV가 검출되며 특히 중증 환자의 혈액에는 SFTSV 농도가 매우 높으므로 혈액을 통해 사람-사람 간 전파가 가능하다 (Tang X, Wu W, Wang H, et al. J Infect Dis 2013;207:736-739.).
SFTSV에 대한 항바이러스제는 아직 개발되지 않아, SFTS 치료는 수혈, 신대체요법 등 장기부전에 대한 보존요법이 근간을 이룬다. 중국에서는 2012년부터 리바비린 정주를 치료지침에 도입하고 있으나 최근 발표된 치료 결과에서는 리바비린 투여군과 비투여군 간 사망률에 차이는 없었다. 따라서, SFTSV에 대한 백신이 필요하나, 아직 백신이 개발되지 않은 실정이다.
본 발명은 신규한 중증열성 혈소판 감소증 바이러스 및 이를 이용한 면역원성 조성물을 제공하는 것을 목적으로 한다.
상기 목적을 달성하기 위하여, 본 발명은 신규한 중증열성 혈소판 감소증 바이러스를 제공한다.
또한, 본 발명은 중증열성 혈소판 감소증의 예방 또는 치료용 면역원성 조성물을 제공한다.
또한, 본 발명은 중증열성 혈소판 감소증 바이러스 또는 이의 항원에 대한 항체를 제공한다.
또한, 본 발명은 중증열성 혈소판 감소증 바이러스의 진단 키트를 제공한다.
또한, 본 발명은 중증열성 혈소판 감소증 바이러스 항체를 검출하는 방법을 제공한다.
또한, 본 발명은 중증열성 혈소판 감소증 바이러스에 대한 항혈청을 생산하는 방법을 제공한다.
아울러, 본 발명은 중증열성 혈소판 감소증 진단에 관한 정보를 제공하는 방법을 제공한다.
본 발명의 중증열성 혈소판 감소증 바이러스는 계통학적으로 A형 및 F형에 속하면서, 종래의 혈소판 감소증 바이러스와 유전적으로 상이한 신규한 바이러스이므로, 본 발명의 신규한 바이러스들을 SFTSV에 대한 교차 면역원성이 우수한 백신으로서 유용하게 이용할 수 있다.
도 1은 본 발명의 신규한 SFTSV 2종과 중국, 일본, 한국에서 분리된 SFTSV들의 L 유전자 계통도를 나타낸 도이다.
도 2는 본 발명의 신규한 SFTSV 2종과 중국, 일본, 한국에서 분리된 SFTSV들의 M 유전자 계통도를 나타낸 도이다.
도 3은 본 발명의 신규한 SFTSV 2종과 중국, 일본, 한국에서 분리된 SFTSV들의 S(NP)유전자 계통도를 나타낸 도이다.
도 4는 본 발명의 신규한 SFTSV 2종과 중국, 일본, 한국에서 분리된 SFTSV들의 S(NS) 유전자 계통도를 나타낸 도이다.
도 5는 본 발명의 A형 및 F형 유전형에 속하는 신규한 바이러스 2종의 L 유전자, M 유전자 및 S 유전자에서의 아미노산 변이 부위를 나타낸 도이다:
concensus: 모든 type의 SFTSV를 기준으로 만든 서열; 및
붉은색 박스: Consensus와 다르게 특정 Genotype에서 나타나는 변이.
도 6은 본 발명에서 분리한 새로운 세부 유전형 A (CB11)및 F (CB10)의 바이러스들을 불활화한 백신의 효과를 생존율, 체중 변화 및 체온 변화를 통해 확인한 도이다.
도 2는 본 발명의 신규한 SFTSV 2종과 중국, 일본, 한국에서 분리된 SFTSV들의 M 유전자 계통도를 나타낸 도이다.
도 3은 본 발명의 신규한 SFTSV 2종과 중국, 일본, 한국에서 분리된 SFTSV들의 S(NP)유전자 계통도를 나타낸 도이다.
도 4는 본 발명의 신규한 SFTSV 2종과 중국, 일본, 한국에서 분리된 SFTSV들의 S(NS) 유전자 계통도를 나타낸 도이다.
도 5는 본 발명의 A형 및 F형 유전형에 속하는 신규한 바이러스 2종의 L 유전자, M 유전자 및 S 유전자에서의 아미노산 변이 부위를 나타낸 도이다:
concensus: 모든 type의 SFTSV를 기준으로 만든 서열; 및
붉은색 박스: Consensus와 다르게 특정 Genotype에서 나타나는 변이.
도 6은 본 발명에서 분리한 새로운 세부 유전형 A (CB11)및 F (CB10)의 바이러스들을 불활화한 백신의 효과를 생존율, 체중 변화 및 체온 변화를 통해 확인한 도이다.
이하, 첨부된 도면을 참조하여 본 발명의 구현예로 본 발명을 상세히 설명하기로 한다. 다만, 하기 구현예는 본 발명에 대한 예시로 제시되는 것으로, 당업자에게 주지 저명한 기술 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 수 있고, 이에 의해 본 발명이 제한되지는 않는다. 본 발명은 후술하는 특허청구범위의 기재 및 그로부터 해석되는 균등 범주 내에서 다양한 변형 및 응용이 가능하다.
또한, 본 명세서에서 사용되는 용어(terminology)들은 본 발명의 바람직한 실시예를 적절히 표현하기 위해 사용된 용어들로서, 이는 사용자, 운용자의 의도 또는 본 발명이 속하는 분야의 관례 등에 따라 달라질 수 있다. 따라서, 본 용어들에 대한 정의는 본 명세서 전반에 걸친 내용을 토대로 내려져야 할 것이다. 명세서 전체에서, 어떤 부분이 어떤 구성요소를 "포함"한다고 할 때, 이는 특별히 반대되는 기재가 없는 한 다른 구성요소를 제외하는 것이 아니라 다른 구성 요소를 더 포함할 수 있는 것을 의미한다.
일 측면에서, 본 발명은 L 유전자의 ORF (6255bp)에서 발현된 단백질 (서열번호 9)의 1061번 아미노산이 글루타메이트이고, M 유전자의 ORF (3222bp)에서 발현된 단백질 (서열번호 10)의 18번째 아미노산이 글리신, 562번째 아미노산이 글리신, 960번째 아미노산이 세린, 988번째 아미노산이 아르기닌 혹은 1053번째 아미노산이 류신이며, S 유전자의 ORF (1674bp)에서 발현된 단백질 NS(294aa) (서열번호 12)의 145번째 아미노산이 라이신 또는 171번째 아미노산이 글루타메이트인, 중증열성 혈소판 감소증 바이러스(severe fever thrombocytopenia syndrome virus, SFTSV)에 관한 것이다.
일 구현예에서, 상기 중증열성 혈소판 감소증 바이러스는 유전형 A에 속하며, 기존의 유전형 A로 분류되던 표준 바이러스의 M 유전자의 ORF (3222bp)에서 발현된 단백질의 18번째 아미노산인 세린이 글리신으로 치환된, 또는 960번째 아미노산인 트레오닌이 세린으로 치환된 바이러스일 수 있다.
일 구현예에서, 상기 중증열성 혈소판 감소증 바이러스는 서열번호 1의 염기서열을 포함하는 L 유전자, 서열번호 2의 염기서열을 포함하는 M 유전자, 서열번호 3의 염기서열을 포함하는 S(NP) 유전자 및 서열번호 4의 염기서열을 포함하는 S(NS) 유전자를 포함할 수 있다.
일 측면에서, 본 발명은 L 유전자의 ORF (6255bp)에서 발현된 단백질 (서열번호 13)의 1061번 아미노산이 아스파르트산이고, M 유전자의 ORF (3222bp)에서 발현된 단백질 (서열번호 14)의 18번째 아미노산이 세린, 562번째 아미노산이 세린, 960번째 아미노산이 트레오닌, 988번째 아미노산이 라이신 혹은 1053번째 아미노산이 메티오닌이며, S 유전자의 ORF (1674bp)에서 발현된 단백질 NS(294aa) (서열번호 16)의 145번째 아미노산이 아르기닌 또는 171번째 아미노산이 아스파르트산인, 중증열성 혈소판 감소증 바이러스에 관한 것이다.
일 구현예에서, 상기 중증열성 혈소판 감소증 바이러스는 유전형 F에 속하며, 기존의 유전형 F로 분류되던 바이러스의 L 유전자의 ORF (6255bp)에서 발현된 단백질의 1061번 아미노산인 글루타메이트가 아스파르트산으로 치환되거나, M 유전자의 ORF (3222bp)에서 발현된 단백질 의 562번째 아미노산인 글리신이 세린으로 치환된 또는 1053번째 아미노산인 류신이 메티오닌으로 치환되거나, 또는 S 유전자의 ORF (1674bp)에서 발현된 단백질 NS(294aa)의 145번째 아미노산인 리신이 아르기닌으로 치환된 또는 171번째 아미노산인 글루타메이트가 아스파르트산으로 치환된 바이러스일 수 있다.
일 구현예에서, 상기 중증열성 혈소판 감소증 바이러스는 서열번호 5의 염기서열을 포함하는 L 유전자, 서열번호 6의 염기서열을 포함하는 M 유전자, 서열번호 7의 염기서열을 포함하는 S(NP) 유전자 및 서열번호 8의 염기서열을 포함하는 S(NS) 유전자를 포함할 수 있다.
본 발명의 일 실시예에서는 분리한 중증열성 혈소판 감소증 바이러스를 유전자 분석하고 계통학적으로 분류한 결과, 각각 A형 및 F형에 속하는 것으로 나타났으며, 이들의 유전자/아미노산 서열이 기존 유전형의 중증열성 혈소판 감소증 바이러스와 상이한 바이러스임을 밝혔다.
본 발명에서 사용되는 용어 "치환"은 각각 다른 아미노산 또는 뉴클레오티드에 의해 하나 이상의 아미노산 또는 뉴클레오티드의 교체를 의미한다.
본 발명의 중증열성 혈소판 감소증 바이러스는 마이너스 단일가닥 RNA 바이러스로 Bunyaviridae과, phlebovirus 속에 속한다. 직경 80~100nm의 구형 바이러스로 작은소참진드기를 매개체로 하며, 유전체는 large(L). Medium(M). small(S) 세그먼트로 구성되어 있으며, RNA dependent RNA polymerase(RdRp), glycoprotein precursor(M), glycoprotein N(Gn), glycoprotein C(Gc), nucleocapsid protein(NP) 및 non-structural protein(NSs)의 6개의 단백질을 코딩한다. 마이너스 또는 안티센스 가닥 (바이러스 단백질을 코딩하는 센스 또는 플러스 가닥에 대한 안티센스)은 단백질 또는 유전자가 안티센스로서 코딩되며, 유전자의 단백질로의 발현을 위해 센스 또는 플러스 가닥 RNA 생성 후, 이로부터 번역을 수행하여 단백질이 생성된다.
일 측면에서, 본 발명은 중증열성 혈소판 감소증 바이러스 또는 이의 항원을 유효성분으로 포함하는, 중증열성 혈소판 감소증의 예방 또는 치료용 면역원성 조성물에 관한 것이다.
일 구현예에서, 본 발명의 면역원성 조성물은 불활화한 중증열성 혈소판 감소증 바이러스와 약제학적으로 수용가능한 담체 (carrier) 또는 아쥬반트(adjuvant)를 포함할 수 있다.
일 구현예에서, 상기 면역원성 조성물은 백신 조성물일 수 있으며, 이의 형태는 생독 백신, 사독 백신, 약독화된 중증열성 혈소판 감소증 바이러스의 유전자를 사용하여 생산한 서브유니트 백신, 벡터 백신, 키메라 백신, DNA 및 RNA 백신으로 구성된 군으로부터 선택될 수 있다.
일 구현예에서, 상기 면역원성 조성물은 서열번호 1의 염기서열을 포함하는 L 유전자, 서열번호 2의 염기서열을 포함하는 M 유전자, 서열번호 3의 염기서열을 포함하는 S(NP) 유전자 및 서열번호 4의 염기서열을 포함하는 S(NS) 유전자를 포함하는 중증열성 혈소판 감소증 바이러스; 및 서열번호 5의 염기서열을 포함하는 L 유전자, 서열번호 6의 염기서열을 포함하는 M 유전자, 서열번호 7의 염기서열을 포함하는 S(NP) 유전자 및 서열번호 8의 염기서열을 포함하는 S(NS) 유전자를 포함하는 중증열성 혈소판 감소증 바이러스들 또는 이들의 항원을 유효성분으로 포함할 수 있다.
본 발명의 면역원성 조성물 (즉, 백신)의 제조를 위해, 본 발명에 따른 바이러스 또는 이의 항원은 생리학적으로 허용가능한 형태로 변환된다. 이는 인플루엔자에 대한 백신접종에 사용된 백신의 제조 경험을 토대로 하여 실시될 수 있다 (Stickl, H. 등에 의해 개시됨. [1974] Dtsch. med. Wschr. 99, 2386-2392). 백신 주사의 제조를 위해 예를 들면, 바이러스 입자는 앰플 내, 바람직하게는 유리 앰플에서 1% 사람 알부민 및 2% 펩톤 존재하의 100ml의 인산-완충 식염수(PBS)에서 동결건조된다. 다르게는, 백신 주사는 제제에서 바이러스의 순차적 동결-건조에 의해 생성될 수 있다. 이 제제는 만니톨, 덱스트란, 당, 글리신, 락토오스 또는 폴리비닐피롤리돈과 같은 추가 첨가제 또는 산화 방지제 또는 비활성 가스, 안정화제 또는 생체내 투여에 적합한 재조합 단백질(예를 들면, 사람 혈청 알부민)과 같은 다른 보조제를 함유할 수 있다. 이어 유리 앰플을 밀봉하고 4℃ 및 실온 사이에서 몇 개월동안 저장할 수 있다. 그러나, 다른 요구사항이 없는 한, 상기 앰플은 바람직하게는 -20℃ 미만에서 저장될 수 있다.
예방접종 또는 치료를 위해, 동결건조물은 0.1 내지 0.5 ml의 수용액, 바람직하게는 생리 식염수 또는 트리스 완충액에 용해되며 전신적으로 또는 국소적으로, 즉 비경구, 피하, 근육내 또는 당업자에게 공지된 임의의 다른 투여경로에 의해 투여될 수 있다. 투여 형태, 복용량 및 투여횟수는 공지된 방식으로 당업자에 의해 최적화될 수 있다. 그러나 가장 일반적으로, 환자는 첫 번째 백신접종 약 한 달 내지 6주 후에 두 번째 백신접종을 받는다.
본 발명에서, 용어 "예방"이란 본 발명에 따른 면역원성 조성물의 투여에 의해 중증열성 혈소판 감소증의 발생, 확산 및 재발을 억제 또는 지연시키는 모든 행위를 의미한다.
본 발명에서 사용된 용어 "치료"란 본 발명에 따른 면역원성 조성물의 투여로 중증열성 혈소판 감소증 및 이로 인한 합병증의 증세를 호전시키거나 이롭게 변경하는 모든 행위를 의미한다. 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자라면, 대한의학협회 등에서 제시된 자료를 참조하여 본원의 조성물이 효과가 있는 질환의 정확한 기준을 알고, 개선, 향상 및 치료된 정도를 판단할 수 있을 것이다.
본 발명에서 유효성분과 결합하여 사용된 "치료학적으로 유효한 양"이란 용어는 이식 거부반응에 의해 발생한 질환을 예방 또는 치료하는데 유효한 양을 의미하며, 본 발명의 조성물의 치료적으로 유효한 양은 여러 요소, 예를 들면 투여방법, 목적부위, 환자의 상태 등에 따라 달라질 수 있다. 따라서, 인체에 사용 시 투여량은 안전성 및 효율성을 함께 고려하여 적정량으로 결정되어야 한다. 동물실험을 통해 결정한 유효량으로부터 인간에 사용되는 양을 추정하는 것도 가능하다. 유효한 양의 결정시 고려할 이러한 사항은, 예를 들면 Hardman and Limbird, eds., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed.(2001), Pergamon Press; 및 E.W. Martin ed., Remington's Pharmaceutical Sciences, 18th ed.(1990), Mack PublishingCo.에 기술되어있다.
본 발명의 약학적 조성물은 약학적으로 유효한 양으로 투여한다. 본 발명에서 사용되는 용어, "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분하며 부작용을 일으키지 않을 정도의 양을 의미하며, 유효용량 수준은 환자의 건강상태, 이식의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 방법, 투여 시간, 투여 경로 및 배출 비율, 치료기간, 배합 또는 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다. 본 발명의 조성물은 개별 치료제로 투여하거나 다른 치료제와 병용하여 투여될 수 있고, 종래의 치료제와 순차적으로 또는 동시에 투여될 수 있으며, 단일 또는 다중 투여될 수 있다. 상기한 요소들을 모두 고려하여, 부작용없이 최소한의 양으로 최대 효과를 얻을 수 있는 양을 투여하는 것이 중요하며, 이는 당업자에 의해 용이하게 결정될 수 있다.
본 발명의 약학적 조성물은 생물학적 제제에 통상적으로 사용되는 담체, 희석제, 부형제 또는 둘 이상의 이들의 조합을 포함할 수 있다. 본 발명에서 사용되는 용어, "약학적으로 허용가능한"이란 상기 조성물에 노출되는 세포나 인간에게 독성이 없는 특성을 나타내는 것을 의미한다. 상기 담체는 조성물을 생체 내 전달에 적합한 것이면 특별히 제한되지 않으며, 예를 들면, Merck Index, 13th ed., Merck & Co. Inc. 에 기재된 화합물, 식염수, 멸균수, 링거액, 완충 식염수, 덱스트로스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 이용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한, 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주이용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다. 더 나아가 당 분야의 적정한 방법으로 또는 Remington's Pharmaceutical Science(Mack PublishingCompany, Easton PA, 18th, 1990)에 개시되어 있는 방법을 이용하여 각 질환에 따라 또는 성분에 따라 바람직하게 제제화할 수 있다.
일 구현예에서, 상기 약학적 조성물은 경구형 제형, 외용제, 좌제, 멸균 주사용액 및 분무제를 포함하는 군으로부터 선택되는 하나 이상의 제형일 수 있으며, 경구형 또는 주사 제형이 더욱 바람직하다.
본 발명에서 사용되는 용어, "투여"란, 임의의 적절한 방법으로 개체 또는 환자에게 소정의 물질을 제공하는 것을 의미하며, 목적하는 방법에 따라 비 경구 투여(예를 들어 정맥 내, 피하, 복강 내 또는 국소에 주사 제형으로 적용)하거나 경구 투여할 수 있으며, 투여량은 환자의 체중, 연령, 성별, 건강상태, 식이, 투여시간, 투여방법, 배설률 및 질환의 중증도 등에 따라 그 범위가 다양하다. 본 발명의 조성물의 경구 투여를 위한 액상 제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데, 통상적으로 사용되는 단순 희석제인 물, 액체 파라핀 이외에 다양한 부형제, 예컨대 습윤제, 감미제, 방향제, 보존제 등이 함께 포함될 수 있다. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성 용제, 현탁제, 유제, 동결건조 제제, 좌제 등이 포함된다. 본 발명의 약학적 조성물은 활성 물질이 표적 세포로 이동할 수 있는 임의의 장치에 의해 투여될 수도 있다. 바람직한 투여방식 및 제제는 정맥 주사제, 피하 주사제, 피내주사제, 근육 주사제, 점적 주사제 등이다. 주사제는 생리식염액, 링겔액 등의 수성 용제, 식물유, 고급 지방산 에스테르(예, 올레인산에칠 등), 알코올 류(예, 에탄올, 벤질알코올, 프로필렌글리콜, 글리세린 등) 등의 비수성 용제 등을 이용하여 제조할 수 있고, 변질 방지를 위한 안정화제(예, 아스코르빈산, 아황산수소나트륨, 피로아황산나트륨, BHA, 토코페롤, EDTA 등), 유화제, pH 조절을 위한 완충제, 미생물 발육을 저지하기 위한 보존제 (예, 질산페닐수은, 치메로살, 염화벤잘코늄, 페놀, 크레솔, 벤질알코올 등) 등의 약학적 담체를 포함할 수 있다.
본 발명에서 사용되는 용어, "개체"란, 상기 암이 발병하였거나 발병할 수 있는 인간을 포함한 원숭이, 소, 말, 양, 돼지, 닭, 칠면조, 메추라기, 고양이, 개, 마우스, 쥐, 토끼 또는 기니아 피그를 포함한 모든 동물을 의미하고, "검체"란 이로부터 분리한 전혈, 혈장, 혈청, 뇨 또는 타액일 수 있다.
본 발명의 약학적 조성물은 약제학적으로 허용 가능한 첨가제를 더 포함할 수 있으며, 이때 약제학적으로 허용 가능한 첨가제로는 전분, 젤라틴화 전분, 미결정셀룰로오스, 유당, 포비돈, 콜로이달실리콘디옥사이드, 인산수소칼슘, 락토스, 만니톨, 엿, 아라비아고무, 전호화전분, 옥수수전분, 분말셀룰로오스, 히드록시프로필셀룰로오스, 오파드라이, 전분글리콜산나트륨, 카르나우바 납, 합성규산알루미늄, 스테아린산, 스테아린산마그네슘, 스테아린산알루미늄, 스테아린산칼슘, 백당, 덱스트로스, 소르비톨 및 탈크 등이 사용될 수 있다. 본 발명에 따른 약제학적으로 허용 가능한 첨가제는 상기 조성물에 대해 0.1 중량부 내지 90 중량부 포함되는 것이 바람직하나, 이에 한정되는 것은 아니다.
일 측면에서, 본 발명은 본 발명의 바이러스 또는 이의 항원을 가지고 면역화에 반응하여 생산된 항체에 관한 것이다.
상기 항체는 전체(whole) 항체 형태일 뿐 아니라 항체 분자의 기능적인 단편을 포함한다. 전체 항체는 2개의 전체 길이의 경쇄(light chain) 및 2개의 전체 길이의 중쇄(heavy chain)를 가지는 구조이며 각각의 경쇄는 중쇄와 다이설파이드 결합(disulfide bond)으로 연결되어 있다. 항체 분자의 기능적인 단편이란 항원 결합 기능을 보유하고 있는 단편을 뜻하며, 항체 단편의 예는 (i) 경쇄의 가변영역(VL) 및 중쇄의 가변영역(VH)과 경쇄의 불변영역(CL) 및 중쇄의 첫번째 불변 영역(CH1)으로 이루어진 Fab 단편; (ii) VH 및 CH1 도메인으로 이루어진 Fd 단편; (iii) 단일 항체의 VL 및 VH 도메인으로 이루어진 Fv 단편; (iv) VH 도메인으로 이루어진 dAb 단편(Ward ES et al., Nature 341:544-546 (1989)]; (v) 분리된 CDR 영역; (vi) 2개의 연결된 Fab 단편을 포함하는 2가 단편인 F(ab')2 단편; (vii) VH 도메인 및 VL 도메인이 항원 결합 부위를 형성하도록 결합시키는 펩타이드 링커에 의해 결합된 단일쇄 Fv 분자(scFv); (viii) 이특이적인 단일쇄 Fv 이량체(PCT/US92/09965) 및 (ix) 유전자 융합에 의해 제작된 다가 또는 다특이적인 단편인 디아바디(diabody) WO94/13804) 등을 포함한다.
일 측면에서, 본 발명은 중증열성 혈소판 감소증 바이러스 또는 이의 항원, 또는 이에 대한 항체를 포함하는 중증열성 혈소판 감소증 바이러스의 진단 키트에 관한 것이다.
일 구현예에서, 상기 키트는 본 발명에에 따른 바이러스를 포함하는 바이러스 시료 및 상기 항원-항체 복합체 검출용 시약을 포함할 수 있다. 상기 항원-항체 복합체 검출용 시약은 방사상면역분석, ELISA (Enzyme linked immunosorbent assay) 또는 면역형광분석용 시약을 포함한다.
일 구현예에서는 항원-항체 복합체 검출은 항원 항체 결합을 통해 항체 및/또는 항원을 간단하게 검출할 수 있는 Ouchterlony 플레이트, 웨스턴블랏, Crossed IE, Rocket IE, Fused Rocket IE, Affinity IE와 같은 면역 전기영동 (Immuno Electrophoresis)로 달성될 수 있다. 이러한 방법에 사용되는 시약 또는 물질은 공지된 것으로서, 예를 들면 항원-항체반응, 항원에 특이적으로 결합하는 기질, 핵산 또는 펩타이드 앱타머, 복합체와 상호작용하는 수용체 또는 리간드 또는 보조인자와의 반응을 통해 검출될 수 있거나, 또는 질량분석기를 이용할 수 있다. 상기 본원의 항원-항체 복합체와 특이적으로 상호작용 또는 결합하는 시약 또는 물질은 칩 방식 또는 나노입자(nanoparticle)와 함께 사용될 수 있다. 상기 면역분석 또는 면역염색의 방법은 Enzyme Immunoassay, E. T. Maggio, ed., CRC Press, Boca Raton, Florida, 1980; Gaastra, W.,Enzyme-linked immunosorbent assay(ELISA), in Methods in Molecular Biology, Vol. 1, Walker, J.M. ed.,Humana Press, NJ, 1984 등에 기재되어 있다. 상술한 면역분석 과정에 의한 최종적인 시그널의 세기를 분석하여 즉, 정상 시료와의 시그널 대조를 수행함으로써, 감염 여부를 진단할 수 있다
일 측면에서, 본 발명은 중증열성 혈소판 감소증 바이러스 또는 이의 항원, 또는 이에 대한 항체를 포함하는 진단 조성물에 관한 것이다.
진단 조성물에 사용되는 본 발명의 상기 화합물들은 검출 가능하게 표식되는 것이 바람직하다. 생분자들을 표식시키는데 사용 가능한 다양한 방법들이 당업자에게 잘 알려져 있고, 본 발명의 범주 내에서 고려된다. 상기 방법들은 Tijssen, 'Practice and theory of enzyme immuno assays', Burden,RHand von Knippenburg (Eds), Volume 15 (1985), 'Basic methods in molecular biology'; Davis LG, Dibmer MD; Battey Elsevier (1990), Mayer et al., (Eds) 'Immunochemical methods in cell and molecular biology' Academic Press, London (1987), or in the series 'Methods in Enzymology', Academic Press, Inc에 기술되어 있다.
통상의 기술자에게 공지되어 있는 표식 방법과 많은 다른 표식들이 있다. 본 발명에서 사용될 수 있는 표식 종류의 예로는 효소, 방사성 동위원소, 콜로이드 금속, 형광 화합물, 화학발광 화합물 및 생발광 화합물이 있다.
통상적으로 사용되는 표식들은 형광물질 (가령, 플루레신, 로다민, 텍사스 레드 등), 효소 (가령, 고추냉이 퍼옥시다아제, β-갈락토시다아제, 알칼리 포스파타아제), 방사성 동위원소 (가령, 32P 또는 125I), 바이오틴, 디곡시게닌, 콜로이드 금속, 화학발광 또는 생발광 화합물 (가령, 디옥세탄, 루미놀 또는 아크리디늄)을 포함한다. 효소 또는 바이오티닐기의 공유 결합법, 요오드화법, 인산화법, 바이오틴화법 등과 같은 표식 방법들이 당 분야에 잘 알려져 있다.
검출 방법들로는 오토라디오그래피, 형광 현미경, 직접 및 간접 효소반응 등이 있으며, 이에 제한되지는 않는다. 통상적으로 사용되는 검출 분석법으로는 방사성 동위원소 또는 비-방사성 동위원소 방법이 있다. 이들은 그중에서도 웨스턴블롯팅, 오버레이-분석법, RIA(Radioimmuno Assay) 및 IRMA(Immune Radioimmunometric Assay), EIA(Enzyme Immuno Assay), ELISA(Enzyme Linked Immuno Sorbent Assay), FIA(Fluorescent Immuno Assay) 및 CLIA(Chemioluminescent Immune Assay)이 있다.
일 측면에서, 본 발명은 항원/항체 복합체가 형성될 수 있는 조건하에서 검체로부터 분리된 시료를 본 발명의 바이러스 또는 이의 항원과 접촉시키는 단계; 및 항원/항체 복합체 형성을 검출하는 단계를 포함하는, 중증열성 혈소판 감소증 바이러스 항체를 검출하는 방법에 관한 것이다.
일 측면에서, 본 발명은 본 발명의 바이러스 또는 이의 항원을 면역반응을 유도하기에 유효한 양으로 사람이 아닌 동물에게 투여하는 단계; 및 상기 중증열성 혈소판 감소증 바이러스에 대한 항체를 함유하는 항혈청 또는 혈장을 수집하는 단계를 포함하는, 사람이 아닌 동물에서 중증열성 혈소판 감소증 바이러스에 대한 항혈청을 생산하는 방법에 관한 것이다.
일 측면에서, 본 발명은 검체로부터 분리된 시료를 본 발명의 바이러스 또는 이의 항원과 접촉시켜 항원-항체 복합체를 형성시키는 단계; 및 상기 복합체의 형성을 검출하는 단계를 포함하는, 중증열성 혈소판 감소증 진단에 관한 정보를 제공하는 방법에 관한 것이다.
하기의 실시예를 통하여 본 발명을 보다 상세하게 설명한다. 그러나 하기 실시예는 본 발명의 내용을 구체화하기 위한 것일 뿐 이에 의해 본 발명이 한정되는 것은 아니다.
실시예 1. 바이러스 분리
대학병원 내원 환자 중 중증열성혈소판 감소증 증상이 의심 되는 환자의 혈액, 동물 (염소 및 유기견)의 혈액 및 야생 진드기 균질물을 이용하여 real time PCR, PCR 및 ELISA 분석으로 SFTSV (severe fever thrombocytopenia syndrome virus, 중증열성 혈소판 감소증 바이러스)의 양/음성을 확인하였다. 구체적으로, 바이러스 감염 전날, VeroE6 세포를 12웰 플레이트에 분주한 뒤, 세포 밀도가 60%가 넘도록 배양한 뒤, 세포를 PBS로 세척하고, 감염 의심 환자의 혈청 300㎕ (전체 혈액을 3000rpm으로 20분간 원심분리하여 얻은 혈청)를 1시간 동안 처리하여 감염시켰다. 감염 후에 혈청을 제거하고 PBS로 세포를 세척한 뒤, 1% FBS DMEM 배지로 교환하여 2주 동안 배양하였다. 2주 후, RT-PCR (reverse transcription 후 real time PCR로 확인) 및 면역형광 분석법(immuno fluoresence assay) (실험실에서 생산한 mouse SFTSV NP 항체를 1차 항체 및 FITC가 counjugation 된 항체를 2차 항체로 사용)으로 바이러스 분리 유무를 확인하였으며, 바이러스가 분리되지 않을 경우에는 처음 감염시켰던 상등액을 또 다른 VeroE6 세포에 감염시키는 방식으로 바이러스를 분리하였다. 분리한 바이러스는 CB11/2017 및 CB10/2017로 명명하였다.
실시예 2. 분리된 바이러스의 유전자 분석
Vero E6세포를 이용하여 분리된 바이러스 CB11/2017 및 CB10/2017를 각각 역전사(Reverse-transcription), PCR 및 NGS(Next generation sequencing)하여 각각의 L, M, S(NP, NS) 유전자 전장 서열을 확인하였다. 구체적으로, 각각의 바이러스에서 RNA를 추출하여 역전사(Reverse-transcription) PCR을 통해 cDNA를 제작하였다. 이후 각각의 SFTS 바이러스의 L, M, S 의 유전자를 PCR을 진행하여 각각의 전장 유전자를 획득하였다. 유전자 서열 분석을 위해 NGS 방법을 사용하였고, 각 바이러스의 L, M, S 유전자를 illumina nextera XT kit를 사용하여 tagmentation 및 index PCR을 illumina에서 제공하는 프로토콜에 따라 진행하였다. 이후 최종 샘플을 illimina miniseq 장비를 이용하여 Fasta Q 파일을 생성하였고, 생성된 파일의 유전자 서열을 CLC main workbench program를 이용하여 각각의 전장 유전자서열을 분석하였다. 확인된 유전자 서열을 한국, 중국 및 일본에서 분리된 종래의 바이러스들의 유전자와 통합하여 유전자 분석한 결과, 본 발명에서 분리한 SFTSV들 CB11, CB10는 현재 중국 혹은 우리나라에서 분리된 바이러스 (YuXJ et al.,N. Engl. J. Med. 2011) 및 우리나라에서 처음 분리된 Gangwon/2012 바이러스의 유전자와는 유전적으로 상이한 새로운 유전형(genotype)의 SFTSV임을 확인하였다. 아울러, MEGA 7.0 프로그램을 사용하여 본 발명의 바이러스들과 한국, 중국, 일본에서 분리되는 바이러스들을 L, M, S(NP, NS) 유전자에 대해 계통학적 유전자 분석을 진행한 결과, 본 발명의 바이러스들은 A 및 F group에 속하는 바이러스임을 확인하였다. (도 1 내지 4). 이에, 본 발명에서 분리한 두 유전형의 SFTSV들은 CB11/2017 및 CB10/2017로 명명 하였다.
실시예 3. 바이러스별 L, M 및 S 유전자
아미노산 서열 차이 확인
3-1. L 유전자 아미노산 서열 차이
본 발명에서 분리한 새로운 세부 유전형 A 및 F의 바이러스들 CB11 및 CB10의 L, M 및 S 유전자의 아미노산 서열을 분석한 결과, L, M 및 S 유전자에서 차이를 나타냈다. 구체적으로, A/F 유전형 중 L 유전자의 ORF(6255bp)는 RdRp를 암호화하고 있으며, 본 발명의 유전형 A에 속하는 CB11 바이러스는 RdRp의 1061번 아미노산이 글루타메이트로 나타났고 (서열번호 9), 유전형 F에 속하는 CB10 바이러스는 RdRp의 1061번 아미노산이 아스파르트산으로 나타났다 (서열번호 13) (도 5A 및 표 1).
3-2. M 유전자 아미노산 서열 차이
본 발명에서 분리한 새로운 세부 유전형 A 및 F의 바이러스들 CB11 및 CB10의 L, M 및 S 유전자의 아미노산 서열을 분석한 결과, A/F 유전형 중 M 유전자의 ORF(3222bp)는 Gn 및 Gc 단백질을 암호화하고 있으며, 본 발명의 유전형 A에 속하는 CB11 바이러스는 M 유전자 ORF의 18번째 아미노산이 글리신, 562번째 아미노산이 글리신, 960번째 아미노산이 세린, 988번째 아미노산이 아르기닌 혹은 1053번째 아미노산이 류신으로 나타났고 (서열번호 10), 유전형 F에 속하는 CB10 바이러스는 M 유전자 ORF의 18번째 아미노산이 세린, 562번째 아미노산이 세린, 960번째 아미노산이 트레오닌, 988번째 아미노산이 라이신 혹은 1053번째 아미노산이 메티오닌으로 나타났다 (서열번호 14) (도 5B 및 표 1).
3-3. S 유전자 아미노산 서열 차이
본 발명에서 분리한 새로운 세부 유전형 A 및 F의 바이러스들 CB11 및 CB10의 L, M 및 S 유전자의 아미노산 서열을 분석한 결과, A/F 유전형 중 S 유전자의 ORF(1674bp)는 NS(882bp,294aa) 및 NP(738bp, 246aa) 단백질을 암호화하고 있으며, 본 발명의 유전형 A에 속하는 CB11 바이러스는 S 유전자가 암호화하는 NS 단백질의 145번째 아미노산이 라이신 또는 171번째 아미노산이 글루타메이트로 나타났고 (서열번호 12), 유전형 F 바이러스는 S 유전자가 암호화하는 NS 단백질의 145번째 아미노산이 아르기닌 또는 171번째 아미노산이 아스파르트산으로 나타났다 (서열번호 16) (도 5C 및 표 1).
실시예 4. 유전형별 유전자 상동성 비교
현재 한국에서 분리되는 SFTSV들을 본 발명의 세부 유전형 A 및 F의 바이러스들 CB11 및 CB10를 포함하여 유전자 분석을 수행하고, 각 유전형별 L, M 및 S 유전자의 상동성을 비교 분석하였다. 그 결과, 같은 유전형에 속하는 바이러스들 사이에는 약 96-100%의 유전자 상동성 (nucleotide level)을 보이는 반면, 서로 다른 유전형 바이러스들 간에는 93-100%의 비교적 낮은 유전자 상동성이 나타났다 (표 2 내지 5).
L 유전자의 상동성 비교
M 유전자의 상동성 비교
S(NP) 유전자의 상동성 비교
S(NS) 유전자의 상동성 비교
실시예 5. 유전형별 교차 면역원성 분석
각 genotype별 교차 면역원성을 비교 분석하기 위해, FRNT50(fifty percent of Focus reduction neutralization test)를 수행하였다. 구체적으로, 본 발명에서 분리한 새로운 세부 유전형 A 및 F의 바이러스들을 대량으로 증식시킨 후, 각각 포르말린 (0.05%)을 첨가하여 불활화한 뒤, 불화화 여부를 3번의 바이러스 분리(isolation)를 통해 확인하였다. 불활화한 상기 백신들 (inactivated whole vaccine)을 20%의 수크로스(sucrose)를 활용하며 초원심분리를 통해 단백질을 생산한 뒤, 이를 페럿에 면역화하였다. 2주 후 페럿에 추가 면역을 수행한 뒤 (2번의 면역 2주 간격), 피를 뽑아 혈청을 분리하였다. 분리한 혈청을 30분 동안 56℃에서 불활성화시킨 뒤, 1/10으로 희석 후, 2배 씩 계단 희석하였다. 200 FFU/ml로 희석한 바이러스를 계단 희석한 바이러스와 1:1로 37℃에서 반응시켰다. 6웰 플레이트에 분주한 VeroE6 세포를 세척한 후 상기 반응시킨 바이러스로 감염시키고, 1시간 후 세척한 뒤, 1% FBS가 함유된 0.8% DMEM 아가로즈 겔을 세포에 부어주었다. 감염 5일 후 포르말린을 활용하여 고정하고 3시간 후, 3번의 세척을 수행한 뒤, 10% triton x-100을 5분씩 실온에서 처리하였다. 그 후, 3번 세척하고 5% BSA로 블로킹을 수행하였다. 생산한 polyclonal NP antibody를 1차 항체로 사용하여 인큐베이션한 뒤 3번 세척하고 2차 항체로 HRP conjugated 항체를 1시간 동안 반응시켜 세척한 뒤, DAB으로 발색하여 결과를 확인하였다 (표 6). 바이러스만 감염시킨 웰의 foucus forming 보다 50% 감소된 값까지를 유효하다고 해석하였다.
serum | ||
virus | A | F |
A | 640 | 320 |
F | 160 | 1280 |
이상의 결과를 요약하면, SFTSV에는 다양한 유전자를 가진 다양한 유전형의 바이러스들이 존재하며, 같은 유전형에 속하는 바이러스들 간에는 비교적 높은 유전자 상동성과 높은 교차면역반응을 나타내나, 다른 유전형의 바이러스들과는 비교적 낮은 유전자 상동성 및 낮은 교차면역원성을 나타냈으므로, 다양한 유전형에 대한 교차면역원성을 나타내기 위해서는 어느 특정 유전형의 바이러스만으로는 제한된 방어능을 보일 것을 유추할 수 있다.
5-2. 백신 효과 확인
본 발명에서 분리한 새로운 세부 유전형 A 및 F의 바이러스들을 대량으로 증식시킨 후, 각각 포르말린 (0.05%)을 첨가하여 불활화한 뒤, 불활화 여부를 3번의 바이러스 분리(isolation)를 통해 확인하였다. 불활화한 상기 백신들 (inactivated whole vaccine)을 2주 간격으로 2회 각 바이러스에 대해 페럿 5마리씩에 면역화한 뒤, 각 바이러스에 대해 1x107.6/ml로 공격 접종 하였다.
공격 접종 결과, 대조군 동물은 10일 이내에 모든 공격 바이러스 감염시 폐사하였으나, 백신한 그룹의 모든 페럿은 생존하였으며, 체온 증가, 체중 감소를 감염 2-8일 이후 확인할 수 있었으나, 이후에는 회복하는 것을 확인할 수 있었다 (도 6).
이상의 결과를 요약하면, SFTSV에는 다양한 유전자를 가진 다양한 유전형의 바이러스들이 존재하며, 같은 유전형에 속하는 바이러스들 간에는 비교적 높은 유전자 상동성과 높은 교차면역반응을 나타내나, 다른 유전형의 바이러스들과는 비교적 낮은 유전자 상동성 및 낮은 교차면역원성을 나타냈으므로, 다양한 유전형에 대한 교차면역원성을 나타내기 위해서는 어느 특정 유전형의 바이러스만으로는 제한된 방어능을 보일 것을 유추할 수 있다.
따라서, 본 발명의 세부 유전형 A 및 F에 속하는 본 발명의 새로운 바이러스 CB11 및 CB10은 SFTSV에 대한 교차 면역원성이 우수한 백신으로서 유용하게 이용될 수 있을 것으로 사료된다.
<110> I.D.Bio.
<120> NOBLE SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUSES
<130> PN1708-279
<160> 16
<170> KoPatentIn 3.0
<210> 1
<211> 6255
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type L gene
<400> 1
atggacttgg aagtgctttg tggtaggata aacgtggaga atgggctgtc tcttggagaa 60
ccaggcctgt acgaccaaat ctacgacagg cctgggctac cagacctaga tgtgactgtc 120
gatgccacag gtgtaacagt ggacatagga gctgtgccag actcagcatc acaactgggt 180
tcatcaatca atgctgggtt gatcacaatc cagctctctg aagcatataa gatcaatcat 240
gacttcacgt tctctggcct gtcaaagaca acagatcgac gcctctcaga ggtgttcccc 300
attacccatg atggttctga tgggatgacc cctgatgtga ttcacaccag attggatggg 360
accattgtgg tggttgaatt ttcaaccact aggagccata acattggggg cctggaggca 420
gcatatagga caaagataga aaaatatagg gacccaatct caaggcgtgt tgatatcatg 480
gagaacccga gggtcttctt tggcgctatt gtagtctcgt caggaggggt tctgtccaac 540
atgcccctga ctcaggatga ggcagaggag ctcatgtaca ggttttgcat tgccaatgag 600
atctacacca aggctagatc tatggatgca gacattgagc tacagaagag tgaggaagag 660
cttgaggcta ttagcagggc actatcattc ttcagtttgt ttgagcctaa cattgaaaga 720
gtagaaggaa cattccctaa ttcagaaatc gaaatgctgg aacagtttct ctcaactcca 780
gctgatgttg acttcatcac caagaccctc aaagcaaaag aggtagaggc ctatgctgat 840
ctttgtgaca gccactacct aaagcctgaa aaaaccattc aggagcgact agagatcaat 900
agatgtgagg ctattgacaa aactcaggac ctcctagctg gtctacatgc aaggagcaac 960
aagcaaacat cattgaatcg agggacagtc aaactcccgc cctggctacc aaagccgtca 1020
agtgagtcaa tagacatcaa gaccgactca ggctttggtt ccttaatgga tcatggcgca 1080
tatggtgagc tgtgggcaaa gtgccttcta gatgtctcgc tgggcaatgt ggagggggta 1140
gtcagcgacc ctgcaaaaga acttgacatt gccatctctg atgatcctga aaaagatacc 1200
cccaaagagg caaagataac ctataggcga ttcaaacctg ccttaagttc aagtgcccgt 1260
caagaatttt ctctccaagg agtggagggg aagaagtgga agagaatggc agcaaaccag 1320
aagaaagaga aggagtccca tgaggcattg agccctttct tggatgttga agacattggg 1380
gatttcctaa cattcaacaa tcttcttgca gattcgaggt atggagatga gtccgtccag 1440
agagcagtgt caatcttgtt ggaaaaggca tctgccatgc aagacacaga gctcactcat 1500
gccctcaacg attcattcaa gaggaaccta agcagtaatg tggttcagtg gtccctttgg 1560
gtctcttgtt tagcacagga gctagctagt gctctgaagc agcactgcag ggctggtgag 1620
ttcatcatca agaagctgaa attctggcct atctatgtca ttatcaagcc gaccaaatca 1680
tcatcccata tcttctacag cttagggatt cgcaaggctg acgtgacaag gaggctcact 1740
ggcagagtct tctctgatac cattgatgct ggggaatggg agctaacaga gttcaaaagc 1800
ctgaagacat gcaagcttac aaaccttgtc aacttgccat gcaccatgct gaactcaata 1860
gctttctgga gagagaagct gggcgtggct ccatggctgg ttcgaaaacc ttgttcagag 1920
ctcagggagc aggtgggcct gaccttcctg atcagtctgg aggacaagtc taagactgag 1980
gagatcatca ccttgacaag gtacacccag atggagggct ttgtctctcc ccccatgctg 2040
cctaagcccc aaaaaatgct agggaaactg gatggacctc tgagaactaa gctacaggtg 2100
tacctcctca ggaagcatct ggattgcatg gtgcgaattg cttctcagcc attcagccta 2160
atccctagag aggggagggt agaatggggg ggaacattcc atgccatctc aggccggtcc 2220
acaaaccttg agaatatggt gaacagctgg tacattgggt actacaagaa caaagaggag 2280
tcaacagagc taaatgccct tggagaaatg tataagaaga tcgtggagat ggaagaggac 2340
aagcccagca gccctgagtt tctagggtgg ggggacactg attcccctaa gaagcatgaa 2400
ttctcacgga gcttcctcag agctgcttgc tcatctctgg agagagaaat tgctcagcga 2460
catggaagac aatggaagca gaaccttgag gagcgtgtcc tgagagagat tgggaccaag 2520
aacattctgg accttgcatc catgaaggcc acaagcaact tttccaaaga ctgggagctc 2580
tactcagaag tccagaccaa agagtaccat aggtctaaac tgttggagaa gatggccaca 2640
ttgattgaga aaggggtcat gtggtacatt gatgctgtag gtcaggcatg gaaggcagtt 2700
ctagatgatg ggtgcatgcg aatctgtctc ttcaagaaga atcagcatgg tggcctcaga 2760
gagatctacg ttatggatgc gaatgcccga cttgtgcagt ttggggtcga gacaatggct 2820
aggtgtgtct gtgaactgag cccacatgag actgttgcca accctaggct caagaattcc 2880
atcatagaga accatgggct gaagtcagcc cgtagtcttg gccctggctc cataaacata 2940
aactcatcca atgacgccaa gaagtggaat caggggcact acacaacaaa gctagctcta 3000
gttctttgtt ggttcatgcc agccaaattc cacagattca tttgggctgc catttccatg 3060
tttcggagaa aaaagatgat ggtggaccta aggtttctag ctcacctcag ttctaaatct 3120
gagtctaggt catctgatcc gtttagggaa gcaatgacag atgccttcca tggtaatagg 3180
gaagtctcat ggatggacaa agggcgaact tacataaaga cagagacagg gatgatgcag 3240
ggcatactgc actttacatc cagtctccta cactcttgtg ttcagagctt ttacaagtct 3300
tatttcgtct cgaagctcaa agagggctac atgggggaaa gcatcagtgg ggtggtggac 3360
gtcatagaag gttctgacga ctctgcgatc atgatcagca tacgccctaa gtcagacatg 3420
gatgaagtcc gatcaaggtt ctttgttgct aacttgctcc actctgtcaa gttcttaaac 3480
cctttgtttg ggatttattc atcagagaaa tcaacagtga acacagtgta ttgtgtcgag 3540
tataactctg aattccattt ccacaggcac ttggttagac ccacactgag atggatagca 3600
gcgtctcacc aaatctcaga gactgaagcc cttgcaagca ggcaagagga ttactctaac 3660
cttctgaccc agtgcttgga agggggggcc tcattctctc ttacctacct catacagtgc 3720
gctcagctcc tacaccacta catgcttcta ggactatgct tacatccctt gtttggaacc 3780
ttcatgggga tgctgatatc agacccagat ccagccctag ggttctttct catggacaac 3840
cctgcattcg cagggggagc gggatttaga ttcaatctgt ggagagcctg caagacaaca 3900
gacctagggc ggaagtatgc atattatttc aatgagatac agggtaaaac aaagggagat 3960
gaggactaca gggctctgga cgccacatcg ggaggaactc tcagccactc tgttatggtg 4020
tactgggggg acaggaagaa gtatcaggcc ttattgagca ggatgggcct tcctgaagac 4080
tgggtggagc agatagatga gaatcctgga gtcctttaca ggagagcagc caacaagaag 4140
gaactactct taaagctggc agagaaggtt cattcacctg gtgtgactag cagcctgagt 4200
aaagggcatg tggtgcctcg ggtggtggca gcaggagtat acctcctctc acgccactgc 4260
tttcgcttta gctcaagcat ccatggcagg ggctcaacac agaaggctag ccttataaaa 4320
ctgttgatga tgtcttctat ttctgccatg aagcacgggg gctcactaaa ccctaatcag 4380
gagcgaatgc tcttccctca ggctcaggag tatgacaggg tgtgcacatt gcttgaggaa 4440
gttgaacacc taacagggaa atttgttgtt agggagagga acattgtcag gagccgcata 4500
gacctgttcc aagagccagt tgacttgcgg tgcaaggcag aagacctggt gtctgaggtg 4560
tggtttggcc tgaaaaggac taagcttggg ccccgtctcc tcaaggaaga gtgggacaaa 4620
cttagggcct catttgcatg gttgagcaca gacccatctg aaacattgag ggatggtcct 4680
tttcttagcc atgtgcagtt tagaaacttc atagcccacg ttgatgccaa atcaagatca 4740
gtcaggctcc taggtgcccc cgtgaagaaa tcaggcgggg tcaccactat aagccaagta 4800
gtcagaatga acttcttccc tggttttagc ctagaagctg agaagagctt agacaatcag 4860
gaaaggcttg agagcatctc catcctcaag catgtcttgt tcatggtctt gaatggccca 4920
tacactgagg agtacaagct ggaaatgatc atagaggcct tctctactct tgtgatacca 4980
cagccatcag aggtcatcag gaaatcaagg accatgactt tatgcctttt atcgaattac 5040
ttgtctagta ggggtgggtc cattctagac cagattgaga gggcacagtc aggcactcta 5100
ggaggattca gcaagcccca gaagacattc attaggccag gaggtggtgt tggctacaag 5160
ggaaaaggtg tgtggactgg agtgatggag gacacccatg tccaaattct gatagatgga 5220
gatgggacta gtaactggct tgaggagatc aggctcagta gtgatgccag gctttatgat 5280
gtcattgaat ccatccgaag gttatgtgat gaccttggga tcaacaacag ggtagcatct 5340
gcatatagag gtcattgcat ggttaggctg agtggattca agatcaagcc agcatcaagg 5400
actgacggct gtccagtcag gattatggaa aggggcttca ggattaggga actccaaaac 5460
ccagatgagg tcaagatgag agtgaggggc gacatcctta acctctctgt cactatacaa 5520
gaaggaaggg tcatgaacat cctaagctac aggccgagag acactgacat atcagagtca 5580
gccgcagcat acctctggag caatcgagac ctcttctcct ttgggaagaa ggagccatcc 5640
tgcagctgga tctgcttgaa aactcttgac aattgggcct ggtcacatgc ctcagttctc 5700
ctggcaaatg ataggaagac ccaaggcatt gacaatagag ctatggggaa catcttcagg 5760
gactgtctcg agggttctct aagaaagcaa gggctgatga ggtcaaaact cacagagatg 5820
gttgagaaga atgtagttcc tttaacaact caagagcttg tcgacatact ggaggaggac 5880
attgactttt cagatgtcat agctgtagag ctctcagagg gttcgcttga cattgaatcc 5940
atctttgatg gagcacctat cttgtggtct gctgaggtgg aagagtttgg agaaggagtg 6000
gtggctgtga gctattccag taagtactat catctaaccc tgatggacca agctgccatc 6060
acaatgtgtg caatcatggg caaggaagga tgtagagggc tccttactga gaagagatgc 6120
atggcagcca tacgagagca ggtacggcca ttcctcatat tcctacaaat tcctgaggac 6180
agcatttctt gggtatctga tcagttctgc gactccaggg gtcttgatga agagagcacc 6240
attatgtggg gttaa 6255
<210> 2
<211> 3222
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type M gene
<400> 2
atgatgaaag tcatctggtt ctcctctctg atctgcttag tcattcaatg cggtggggat 60
acaggcccaa tcatctgcgc aggacccatc cactcaaaca agagtgctga cataccccac 120
ctgcttggct actctgagaa gatttgtcag atagatcggc tgatacatgt ttcgtcatgg 180
cttagaaacc actcacaatt tcagggctac gtagggcagc gaggtggacg atctcaggtg 240
agctactacc cagctgaaaa ttcttactca aggtggagtg gacttctaag cccctgtgat 300
gctgattggc ttgggatgct tgtcgtgaag aaggccaagg ggtctgatat gatagttcca 360
gggccttcat acaaggggaa agtctttttt gaacggccaa cttttgatgg atacgtaggc 420
tggggctgtg gtagtgggaa gtctaggact gagtcaggtg agctctgcag ttcagactcc 480
gggactagtt ctggtcttct gccctcagat agggttctct ggataggtga tgttgcttgt 540
cagcctatga cacccatccc tgaggagaca tttctggagc tgaagagctt tagccaaagt 600
gaattcccag acatatgcaa aattgatggc attgtgttca accagtgtga gggtgagagt 660
ctacctcagc cctttgatgt tgcatggatg gatgttggcc actctcataa aatcatcatg 720
agggagcaca agaccaaatg ggtacaagag agctcatcca aggattttgt gtgctacaag 780
gaagggactg ggccttgttc tgaatcagaa gaaaagactt gcaagaccag tggatcatgc 840
aggggggaca tgcagttttg caaggtggca ggttgtgaac atggggaaga ggcatctgaa 900
gccaagtgca gatgctcact tgtgcacaag cccggggaag tcgttgtgtc atatggaggg 960
atgcgtgtca gaccaaagtg ctatggtttc tccagaatga tggcaacact ggaggtgaac 1020
gaaccagagc agaggaatgg tcaatgcact ggctgccatc tagaatgcat aaatgggggt 1080
gtgaggctaa tcactctaac cagtgagctc aagtcagcta ctgtctgcgc ttctcacttc 1140
tgcagttctg ccacaagtgg taagaaaagc acggagattc aattccactc aggatcattg 1200
gttgggaaaa cagcaatcca cgttaaaggg gcattggtag atggaactga attcacattt 1260
gagggtagtt gcatgttccc agatggttgt gatgcagtgg actgcacatt ctgtcgtgag 1320
tttctaaaaa atccccagtg ctaccctgca aagaagtggc tgttcatcat tattgtcatc 1380
ctccttggat atgcaggcct catgctactc accaatgttc ttaaggcaat tggggtttgg 1440
gggtcatggg tcatagctcc agtgaagcta gtgtttgcca tcataaagaa actaatgaga 1500
gctgtgagct gcctgatggg gaaattgatg gatagaggaa ggcaagtgat ccatgaggaa 1560
ataggggaga atagagaggg caaccaagat gatgttagga ttgagatggc cagacccagg 1620
agggtaaggc attggatgta ctcgcctgtc atcctgacta ttctagcaat ggggcttgct 1680
gagggctgtg atgagatggt ccatgctgat tctaaacttg tttcgtgcag gcaagggagc 1740
ggaaatatga aggaatgtgt cacaactggg agggcgcttc ttcctgcagt gaacccaggg 1800
caagaggcgt gtctgcactt cacggcacct ggaagtccgg actcaaaatg tctcaaaatt 1860
aaggttaaga ggatcaacct aaaatgtaaa aagtcatcat catattttgt tcctgatgcc 1920
cggtccaggt gtacatcagt gaggagatgt cgttgggcag gggactgcca gtctgggtgc 1980
ccccctcatt tcacatccaa ctccttttct gatgattggg caggtaagat ggacagggct 2040
ggtctaggat tcagtggctg ctctgatgga tgtggaggag cagcctgtgg ttgctttaat 2100
gcggcccctt cttgcatttt ctggaggaaa tgggtagaga atccacatgg gatcatctgg 2160
aaagtatctc catgtgccgc atgggtccca tcagcggtta tagagctaac aatgccctca 2220
ggggaggtga ggacattcca ccccatgagc ggaatcccca cacaagtctt caagggtgtg 2280
agtgtaactt acttgggctc agatatggag gtgtcaggct tgactgacct gtgtgagata 2340
gaagagctca agtcaaagaa gcttgcatta gctccctgca accaggctgg tatgggggtt 2400
gtaggcaagg ttggagagat acagtgcagt agcgaggaaa gtgcccgtac cataaaaaaa 2460
gatgggtgca tatggaatgc tgacctcgtg ggtatagagc tacgggtgga tgacgctgtg 2520
tgctactcta agatcactag tgtggaggca gttgcaaact actccgccat acccaccact 2580
attggggggc tgaggtttga gagaagccat gacagccagg gcaaaatatc tggtagcccc 2640
ctggacatca cagctataag aggatctttt tctatcaatt atagaggcct tcgactgagc 2700
ctctcagaaa ttactgctac ttgcacaggg gaagtgacaa atgtgagtgg gtgttattct 2760
tgcatgacag gcgccaaagt ctccatcaag ttgcatagca gcaaaaatag cactgcccat 2820
gtaagatgca aaggggatga gactgccttc agtgtcttgg agggagtcca tagctactct 2880
gtcagtctca gttttgatca tgcagtagtt gatgagcagt gccaactgaa ctgtggggga 2940
catgagagtc aagtgactct gagaggcaac ctcatcttcc tggatgtccc gaaatttgtg 3000
gatggcagct acatgcagac atatcatagc actgtgccca caggggcaaa tatcccaagc 3060
cctacagatt ggctaaatgc cttgtttggc aatgggctga gtaggtggat cctgggggtg 3120
ataggggtcc tactgggggg attggctctc tttttcttga tcatgtcttt gttcaagctg 3180
ggaacaaaac aggtatttcg atcgaggacg aagctggctt aa 3222
<210> 3
<211> 738
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type NP gene
<400> 3
atgtcagagt ggtccaggat tgcagtggag tttggtgagc agcagctcaa tttgactgag 60
cttgaggatt tcgcgagaga gctggcctat gaaggccttg atcctgcttt gatcatcaag 120
aagctgaagg agacaggtgg agatgattgg gtgaaggata cgaagttcat cattgtcttt 180
gccctgactc gaggcaataa gatcgtcaag gcatcaggga aaatgtctaa ctcagggtct 240
aagaggttga tggcactcca agagaaatat ggactggttg agagggcaga aaccaggctc 300
tcaatcactc ctgtgagggt agcgcagagc cttcccacct ggacatgtgc agcagcagca 360
gccttaaagg agtatctccc agtggggcca gccgtcatga acctgaaggt tgagaattat 420
ccacctgaga tgatgtgcat ggcctttggg tccctgattc caactgcagg agtatctgaa 480
gccacaacca agacccttat ggaggcctac tctctgtggc aagatgcctt caccaagact 540
atcaatgtga agatgcgtgg agccagcaag acagaagttt acaactcctt cagggaccct 600
ctccatgctg ctgtgaactc tgtcttcttt cccaatgatg ttcgggtgaa gtggctgaag 660
gccaagggaa tccttggccc agatggggtt cccagcagag ctgctgaggt tgctgctgct 720
gcttacagaa acctgtaa 738
<210> 4
<211> 882
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type NS gene
<400> 4
atgtcgctga gcaaatgctc caacgttgac ctcaaatctg tagcaatgaa tgctaacact 60
gttaggcttg agccttccct gggagagtac cccactctta ggagagacct cgtcgaatgc 120
tcttgtagtg tgttgacttt gtcaatggtc aagaggatgg gtaagatgac caacacagta 180
tggttgtttg gcaaccctaa aaatcctctt catcagcttg agcctggact tgagcagctg 240
ttagacatgt actacaagga catgaggtgc tactcccaga gagaactgag tgctcttagg 300
tggcctagtg ggaagccatc tgtatggttc ctacaggcag ctcatatgtt cttctccatc 360
aagaacagct gggcaatgga aaccggaaga gagaattggc ggggcctctt ccacaggata 420
acaaaaggcc aaaagtatct ttttgaaggg gacatgatat tggattctct tgaagccata 480
gagaagcgaa gacttagact tgggttgcct gagattctga taactggtct atccccaatt 540
ctggatgtgg ctctcctcca gatagagtca cttgcaaggc taagaggcat gagcttgaac 600
caccacttgt tcacttcttc ctcattgcgt aagcctctgt tagactgttg ggatttcttc 660
attcctatcc gcaaaaagaa gacagatggc tcatacagtg tcttggatga ggatgatgag 720
cctggggtcc tccagggtta cccatatctg atggcacact atttaaatag gtgcccattc 780
cacaacctca tcaggtttga tgaagaactg agaactgcag ccctgaacac catttgggga 840
agagattggc cagccattgg tgacctcccg aaggaggtct aa 882
<210> 5
<211> 6255
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type L gene
<400> 5
atggacttgg aagtgctttg tggtaggata aacgtggaga atgggctgtc tcttggagaa 60
ccaggcctgt acgaccaaat ctacgacagg ccagggctcc cagacctaga tgtgactgtc 120
gatgccacag gtgtgacagt ggacataggg gctgtgccag actcagcatc acaactgggt 180
tcatcaatca atgctgggtt gatcacaatc cagctctctg aagcatataa gatcaatcat 240
gacttcacgt tttctggtct gtcaaagaca acagaccgac gcctctcaga ggtattcccc 300
attacccatg atggttctga tgggatgacc cctgatgtga tccacaccag attggatgga 360
accatagtgg tggttgaatt ttcaaccact aggagccata acattggggg cctggaggca 420
gcatatagga caaagataga aaaatatagg gacccaatct caaggcgtgt tgatatcatg 480
gagaacccga gggtcttctt cggcgtaatt gtagtctcgt caggaggggt cctgtccaac 540
atgcccttga ctcaggatga ggcagaggag ctcatgtata ggttctgcat agccaatgag 600
atctacacta aggctagatc tatggatgca gacattgagc tacagaaaag tgaagaagag 660
cttgaggcta ttagcagggc actatcattc ttcagtttgt ttgagcctaa cattgaaaga 720
gtggaaggaa cattccctaa ttcagaaatc gagatgctgg agcagttcct ctcaacgcca 780
gctgatgttg acttcatcac caagaccctc aaagcaaaag aagtagaagc ctatgctgat 840
ctttgtgaca gccactacct aaagcctgag aaaaccatac aggagcggct agagatcaat 900
agatgtgagg ctattgacaa aactcaagac ctcctagctg gcctgcatgc aaggagcaac 960
aagcaaacat cattgaatcg agggacagtc aaactcccgc cctggctacc aaagccatca 1020
agtgagtcaa tagacatcaa gaccgactca ggctttggtt ccttaatgga tcatggcgca 1080
tatggtgagc tgtgggcaaa gtgccttcta gatgtctcgc taggcaatgt ggagggggta 1140
gtcagtgacc ctgcaaaaga acttgacatt gccatctctg atgatccaga aaaagacacc 1200
cccaaagagg caaagataac ctataggcga ttcaagcctg ccttaagttc gagtgcccgt 1260
caggaattct ctctccaagg agtggagggg aagaagtgga agagaatggc agcaaatcag 1320
aagaaagaga aggagtccca tgagacattg agcccgttct tggatgttga tgacatagga 1380
gatttcctaa cattcaacaa tcttcttgca gattcgaggt atggagacga gtccatccag 1440
agagctgtgt caatattgct ggaaaaggca tctgccatgc aagacacaga gctcactcat 1500
gccctcaacg attcatttaa gaggaatcta agcagcaatg tggttcagtg gtctctttgg 1560
gtctcctgtt tagcacagga gctagctagt gccctgaagc agcactgcag ggccggtgag 1620
ttcatcatca agaagctgaa gttctggcct atctatgtca ttatcaagcc gaccaaatca 1680
tcatcccata tcttctacag cttagggatc cgcaaggctg acgtgacaag gaggctaact 1740
ggtagagtct tctctgacac cattgatgct ggggaatggg aactaacaga gttcaaaagc 1800
ctgaagacat gcaagctcac gaatcttgtc aacttgccat gcaccatgct gaactcaata 1860
gctttctgga gagagaagct gggcgtggct ccatggctgg ttagaaagcc ctgttcagag 1920
ctcagggagc aggtgggcct gaccttcctg gtcagtctgg aggacaagtc taagactgag 1980
gagatcatca ccttgacaag gtacacccag atggagggct ttgtctctcc tcccatgctg 2040
cctaagcccc aaaagatgct agggaaactg gaagggcctt tgagaactaa gctacaggta 2100
tacctcctca ggaagcacct ggattgcatg gtgcgaattg cgtctcagcc tttcagccta 2160
atccctagag aggggagggt agagtgggga ggaacattcc atgccatctc aggccggtcc 2220
acaaaccttg agaacatggt gaacagctgg tacattgggt actacaagaa caaagaggag 2280
tcaacagagc taaatgccct cggagaaatg tataagaaga ttgtggagat ggaagaggac 2340
aagcccagca gtcctgagtt tctagggtgg ggggacacag attcccccaa gaagcatgaa 2400
ttctcacgga gcttcctcag agctgcttgc tcatctctag agagagaaat tgctcagcga 2460
catgggaggc aatggaagca gaaccttgag gagcgtgtcc tgagagagat tggggccaag 2520
aacatcctgg accttgcatc catgaaggct acaagcaact tttccaaaga ctgggagctc 2580
tactcagaag tccagaccaa agagtaccat aggtccaaac tactggagaa gatggccaca 2640
ttgattgaga agggggttat gtggtacatt gatgctgtgg gccaggcatg gaaggcagtt 2700
ctggatgacg ggtgcatgcg aatctgtctc ttcaaaaaga atcagcatgg tggccttaga 2760
gagatctacg ttatggatgc gaatgcccgg ctcgtgcagt ttggggttga gaccatggct 2820
aggtgtgtct gtgagctgag ccctcatgag actgttgcta accctcggct caagaattcc 2880
atcatagaga accatggact gaagtcagcc cgtagtcttg gccctggctc tataaacata 2940
aactcatcca atgatgccaa gaagtggaat caggggcact acacaacaaa gctagcttta 3000
gttctttgtt ggttcatgcc agctaaattc cacagattca tttgggctgc catttccatg 3060
tttcggagaa aaaagatgat ggtggaccta aggtttttag ctcacctcag ttctaaatct 3120
gagtctaggt catctgatcc gtttagggaa gcaatgacag atgccttcca tggtaatagg 3180
gatgtctcat ggatggacaa agggcgaact tacattaaga cagagacagg aatgatgcag 3240
ggcatactgc acttcacatc cagtctcctc cactcttgtg ttcagagctt ctacaagtct 3300
tatttcgtct cgaagctcaa ggagggctac atgggggaaa gcatcagtgg ggtggtggat 3360
gtcatagaag gctctgacga ctcagcgatc atgattagca tacgccctaa gtcagacatg 3420
gatgaagttc gatccaggtt ctttgttgct aacttgctcc actctgttaa gttcttgaat 3480
ccattgtttg ggatttattc atcagagaaa tcaacagtga acacagtgta ttgtgtcgaa 3540
tataactctg aattccattt ccacaggcac ttggttagac ccacactgag atggatagca 3600
gcgtctcatc aaatctcaga gactgaagcc cttgcaagca ggcaagagga ttactccaac 3660
cttctaaccc agtgcttgga aggaggggcc tcattctctc ttacctacct catacagtgc 3720
gctcagctcc tgcaccacta catgcttcta ggactttgct tacatcccct gtttggaacc 3780
ttcatgggga tgctgatatc agacccagat ccagccctag ggttcttcct catggacaac 3840
cctgcattcg cagggggagc aggatttaga ttcaatctgt ggagagcctg caagactaca 3900
gaccttgggc ggaagtatgc atattatttt aatgagatac agggtaagac aaagggagat 3960
gaggactaca gagctctgga cgccacatcg ggaggaactc tcagccactc tgttatggtg 4020
tactgggggg acaggaagaa gtatcaagcc ttattgaaca ggatgggcct tcctgaagac 4080
tgggtggagc agatagatga gaatcctgga gtcctctaca ggagagctgc caacaagaaa 4140
gaactgctct taaagctggc agagaaggtt cattcacctg gtgtgactag cagcctgagt 4200
aaagggcatg tagtgcctcg ggtggtggca gcaggagtgt acctcctctc acgtcattgc 4260
tttcgcttta gttcaagcat ccatggcagg ggctcaacgc agaaggctag ccttataaaa 4320
ttgctgatga tgtcttctat ttctgccatg aagcatgggg gctcactgaa ccctaaccag 4380
gagcgaatgc tcttccctca ggctcaagag tatgacagag tatgcacatt gcttgaggaa 4440
gttgaacacc taacagggaa atttgttgtt agggagagaa acattgtcag gagccgcata 4500
gatttgttcc aagagccagt ggacttgcgg tgcaaggcag aagatctggt gtcagaggtg 4560
tggtttggcc tgaaaaggac taaacttgga ccccgtctcc tcaaggaaga gtgggataaa 4620
cttagggcct catttgcatg gctgagcaca gacccatctg aaacattgag ggatggtcct 4680
tttcttagcc atgtgcagtt taggaacttc atagcccacg ttgatgccaa atcaagatca 4740
gtcaggctcc taggtgcccc cgtgaagaag tcaggtgggg tcaccaccat aagccaagtg 4800
gtcagaatga acttcttccc tggttttagc ctagaagctg agaagagctt agacaatcag 4860
gaaagacttg agagtatctc catcctcaag catgtcttgt tcatggtctt gaatggccca 4920
tacactgagg agtacaagct ggagatgatc atagaggcct tctctactct tgtgatacca 4980
cagccatcag aggtcatcag gaaatcaagg accatgactt tatgcctctt atcgaattac 5040
ttgtccagta ggggtgggtc cattctagac caaattgaga gggcacagtc aggcactcta 5100
ggaggcttca gcaagcccca gaagacattt attaggccag gaggtggtgt tggctacaag 5160
ggaaaaggtg tgtggactgg agtgatggag gacacccatg ttcaaattct gatagatgga 5220
gatggtacaa gtaactggct cgaggagatc aggctcagta gtgatgctag gctttatgat 5280
gtcattgaat ccatccgaag gttatgtgat gaccttggga tcaacaacag ggtggcatct 5340
gcatatagag gccattgtat ggttaggctg agtggattca agatcaagcc agcatcaagg 5400
actgacggct gtccagtcag gattatggaa aggggcttca gaattaggga acttcaaaac 5460
ccagatgagg tcaaaatgag agtgaggggc gacatcctca acctctctgt cactatacaa 5520
gaaggaaggg tcatgaacat cctaagctac aggccgagag acactgatat atcagagtca 5580
gccgcagcat acctctggag caatcgagac ctcttctcct ttgggaagaa ggagccgtcc 5640
tgcagctgga tctgcttgaa aactctagat aattgggcct ggtcacatgc ctcagttctc 5700
ctggcaaatg ataggaagac ccaaggtatt gacaatagag ctatggggaa cattttcagg 5760
gactgtctcg agggttctct tagaaagcaa gggttgatga ggtcaaagct cacagagatg 5820
gtggagaaga atgtagttcc tttaacaact caagagcttg tcgacatcct ggaggaggac 5880
attgactttt cagatgtcat agctgtagag ctctcagagg gatcacttga cattgaatcc 5940
atctttgatg gggcacctat cttgtggtct gctgaggtgg aagagtttgg agaaggagtg 6000
gtggctgtga gctattcaag caagtactat catctgaccc tgatggacca agctgccatc 6060
acaatgtgtg caatcatggg taaggaaggc tgcagagggc tccttactga gaagagatgc 6120
atggcagcca tacgagagca ggtgcggcca ttcctcatat tcctgcaaat tcctgaggac 6180
agcatttctt gggtgtctga tcagttctgc gactccaggg gtcttgatga agagagcacc 6240
attatgtggg gttaa 6255
<210> 6
<211> 3222
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type M gene
<400> 6
atgatgaaag tcatctggtt ctcctctctg atctgctttg tcattcaatg cagtggggac 60
tcaggcccaa tcatctgcgc aggacccatc cactcaaaca agagtgctga catacctcac 120
ctgctgggtt actctgagaa gatatgtcag atagatcggc tgatacatgt ttcgtcatgg 180
ctcaggaacc actcacaatt tcagggctac gtaggccagc gaggtggacg ctctcaggtg 240
agctactacc cagctgaaaa ttcttactca aggtggagtg ggcttctaag cccctgtgat 300
gctgattggc ttgggatgct tgtcgtgaag aaggccaagg ggtctgatat gatagttcct 360
gggccttcat acaagggaaa agtctttttt gagcggccaa cttttgatgg atatgtaggc 420
tggggctgtg gcagtgggaa gtctaggaca gagtcaggag agctctgcag ttcagactcg 480
gggactagct ctggtcttct gccctcagat agggttctct ggataggtga tgttgcttgt 540
cagcctatga cacccatccc tgaagagaca tttctggagc tgaagagttt tagccaaagt 600
gaattcccag acatatgcaa aattgatggc attgtattca accagtgtga gggtgagagc 660
ctacctcagc cctttgatgt tgcatggatg gatgttggcc actctcataa aatcatcatg 720
agggagcaca agaccaaatg ggtgcaagag agctcatcca aggattttgt gtgctacaag 780
gaagggactg ggccttgttc tgaatcagaa gaaaagactt gcaagaccag tggatcatgc 840
aggggggaca tgcagttctg caaggtagca ggttgtgaac atggggaaga ggcatctgaa 900
gccaagtgta gatgctcact tgtgcacaag cccggagaag tcgttgtgtc atatggaggg 960
atgcgtgtca gaccaaagtg ctatggtttc tccagaatga tggcaacact ggaggtgaac 1020
caaccagagc aaaggattgg tcaatgcact ggctgccatc tggaatgcat aaatgggggt 1080
gtgaggctaa taactctaac cagtgagctc aagtcagcta ctgtctgtgc ttctcacttt 1140
tgtagttctg ccacaagtgg caagaaaagc acggagattc aattccactc aggatcattg 1200
gttgggaaaa cagcaataca cgtcaaaggg gcattggtag atggaactga attcacattt 1260
gagggtagtt gcatgttccc agatggttgt gatgcggtgg actgcacttt ctgtcgtgag 1320
tttctaaaaa atccccagtg ctaccctgca aagaagtggc tgttcatcat tattgtcatc 1380
ctccttgggt atgcaggcct catgctactc accaatgtcc tcaaggcaat tgggatttgg 1440
ggatcatggg tcatagctcc agtgaagcta atatttgcca tcataaagaa actaatgaga 1500
actgtgagct gcttgatggg gaaattgatg gataggggaa ggcaagtgat ccatgaggag 1560
ataggggaga atagagaggg caaccaagat gatgttagga ttgagatggc aagacccaga 1620
agggtaaggc attggatgta ctcacctgtc atcctgacta ttttagcaat agggcttgct 1680
gagagctgtg atgagatggt ccatgctgat tctaagcttg tttcatgcag gcaagggagc 1740
ggaaatatga aggaatgtgt cacaactggg agggcgcttc ttcctgcggt gaacccaggt 1800
caagaggcat gtctgcactt cacggcacct gggagtccgg actcaaaatg tctcaaaatt 1860
aaggttaaga ggatcaacct aaaatgtaag aagtcatcat catattttgt tcctgatgcc 1920
cggtccagat gtacatcagt gaggagatgt cgttgggctg gagactgcca gtctgggtgc 1980
ccccctcatt tcacatccaa ctccttttct gatgattggg caggtaagat ggacagggct 2040
ggtctagggt tcagtggctg ctctgatgga tgtggaggag cagcctgcgg ctgctttaat 2100
gcagcccctt cttgcatctt ctggaggaaa tgggtagaga acccacatgg gatcatctgg 2160
aaagtgtctc cttgtgccgc atgggtccca tcggcagtca tagagctaac aatgccctca 2220
ggggaggtga ggacattcca ccccatgagt ggcatcccca cacaagtctt caagggtgtg 2280
agtgtgactt acttgggctc agatatggag gtgtctggct tgactgacct atgtgagata 2340
gaggagctca agtccaagaa gctggcatta gctccctgca accaggctgg catgggggtt 2400
gtaggcaagg ttggagagat acagtgcagt agcgaggaaa gtgcccgtac cataaaaaaa 2460
gatgggtgca tatggaatgc agaccttgtg ggcatagagc tacgagtgga tgacgctgtg 2520
tgctactcta agatcactag tgtggaagca gttgcaaact actctgccat acccaccact 2580
attggggggc tgaggtttga gagaagccat gacagccagg gtaaaatatc tggtagcccc 2640
ctggacatca cagctataag aggatctttt tctgttaatt atagaggcct tcgactgagc 2700
ctctcagaaa ttactgctac ctgcacaggg gaggtgacaa atgtgagtgg atgttattct 2760
tgcatgacag gcgccaaagt ctctatcaaa ctacatagca gcaaaaatag cactgcccat 2820
gtaagatgca aaggggatga gactgcattc agtgtcttgg agggggtcca tagttacact 2880
gtcaatctca gttttgacca tgcagtggtc gatgagcagt gccaactgaa ctgtggggga 2940
catgagagtc aagtgactct aaaaggcaac cttatcttcc tggatgtccc aaaatttgtg 3000
gatggcagct acatgcagac atatcatagc actgtgccca caggggcaaa tatcccaagc 3060
ccaacagact ggctgaatgc cttgtttggc aatgggctga gtaggtggat cctgggggtg 3120
ataggggttc tacttggggg gttggctctc tttttcatga ttatgtcttt gttcaagctg 3180
ggaacaaaac aggtatttcg atcaaggacg aagctggctt ag 3222
<210> 7
<211> 738
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type NP gene
<400> 7
atgtcagagt ggtccaggat tgcagtggag tttggtgagc agcagctcaa tttgactgag 60
cttgaggatt tcgcgagaga gctagcctat gaaggccttg atcctgcttt gatcatcaag 120
aagctgaagg agacaggtgg agatgactgg gtgaaggata ctaagttcat cattgtcttt 180
gccctgactc gaggcaataa gatcgtcaag gcatcaggga agatgtcaaa ctcagggtca 240
aagaggttga tggcactcca ggagaaatat gggctggttg agagggcaga gaccaggctc 300
tcaatcaccc ctgtaagggt agcgcagagc ctccccactt ggacatgtgc tgcagcagca 360
gccttaaagg agtatctccc agtggggcca gccgtcatga acctgaaggt tgagaattat 420
cccccagaga tgatgtgcat ggccttcggg tccctgattc caactgcagg ggtatctgaa 480
gccacgacca agaccctgat ggaggcttac tctttatggc aagatgcctt caccaagact 540
atcaatgtga agatgcgcgg agccagcaag acagaagttt acaactcctt cagggatcct 600
ctccatgctg ctgtgaactc tgtcttcttc cccaatgatg ttcgggtgaa gtggctgaag 660
gccaagggaa tccttggccc agatggggtc cccagcagag ctgctgaggt tgctgctgct 720
gcttacagga acctgtaa 738
<210> 8
<211> 882
<212> DNA
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type NS gene
<400> 8
atgtcgctga gcaaatgctc caacgttgat ctcaaatctg ttgcaatgaa tgccaacaca 60
gtcaggcttg agccatctct aggagagtac cccactctta ggagggacct cgttgaatgc 120
tcttgcagtg tgttgactct gtcgatggtc aagaggatgg gtaagatgac caacacagta 180
tggttgtttg gcaaccccaa aaatcctctt caccagcttg agcctggact tgagcagcta 240
ttggacatgt actacaagga catgaggtgc tactcccaga gagagctgag tgctcttagg 300
tggcctagtg ggaagccatc tgtatggttc ttgcaggcag ctcatatgtt cttctccatc 360
aagaacagct gggcaatgga aactgggaga gagaactggc ggggcctctt ccacaggata 420
acaaaaggcc gaaggtatct ttttgaaggg gacatgatat tggattctct agaagccata 480
gagaagcgaa ggcttagact tgggttacct gatatcctaa taactggact gtccccaatt 540
ctggatgtgg ccctccttca gatagagtca cttgcaaggc taagaggcat gagcttgaac 600
caccacttgt tcacttcttc ctcattgcgt aagcctctgt tggactgttg ggacttcttt 660
atccctatcc gcaaaaagaa gacagatggc tcatacagtg tcttggatga ggatgatgag 720
cctggggtcc ttcaaggtta cccatatctg atggcacact atttaaacag gtgcccattc 780
cacaacctca tcaggtttga tgaggagctg agaactgcag ccctgaacac catctgggga 840
agagattggc cagccattgg tgaccccccg aaggaggtct aa 882
<210> 9
<211> 2085
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type L
<400> 9
Met Asp Leu Glu Val Leu Cys Gly Arg Ile Asn Val Glu Asn Gly Leu
1 5 10 15
Ser Leu Gly Glu Pro Gly Leu Tyr Asp Gln Ile Tyr Asp Arg Pro Gly
20 25 30
Leu Pro Asp Leu Asp Val Thr Val Asp Ala Thr Gly Val Thr Val Asp
35 40 45
Ile Gly Ala Val Pro Asp Ser Ala Ser Gln Leu Gly Ser Ser Ile Asn
50 55 60
Ala Gly Leu Ile Thr Ile Gln Leu Ser Glu Ala Tyr Lys Ile Asn His
65 70 75 80
Asp Phe Thr Phe Ser Gly Leu Ser Lys Thr Thr Asp Arg Arg Leu Ser
85 90 95
Glu Val Phe Pro Ile Thr His Asp Gly Ser Asp Gly Met Thr Pro Asp
100 105 110
Val Ile His Thr Arg Leu Asp Gly Thr Ile Val Val Val Glu Phe Ser
115 120 125
Thr Thr Arg Ser His Asn Ile Gly Gly Leu Glu Ala Ala Tyr Arg Thr
130 135 140
Lys Ile Glu Lys Tyr Arg Asp Pro Ile Ser Arg Arg Val Asp Ile Met
145 150 155 160
Glu Asn Pro Arg Val Phe Phe Gly Ala Ile Val Val Ser Ser Gly Gly
165 170 175
Val Leu Ser Asn Met Pro Leu Thr Gln Asp Glu Ala Glu Glu Leu Met
180 185 190
Tyr Arg Phe Cys Ile Ala Asn Glu Ile Tyr Thr Lys Ala Arg Ser Met
195 200 205
Asp Ala Asp Ile Glu Leu Gln Lys Ser Glu Glu Glu Leu Glu Ala Ile
210 215 220
Ser Arg Ala Leu Ser Phe Phe Ser Leu Phe Glu Pro Asn Ile Glu Arg
225 230 235 240
Val Glu Gly Thr Phe Pro Asn Ser Glu Ile Glu Met Leu Glu Gln Phe
245 250 255
Leu Ser Thr Pro Ala Asp Val Asp Phe Ile Thr Lys Thr Leu Lys Ala
260 265 270
Lys Glu Val Glu Ala Tyr Ala Asp Leu Cys Asp Ser His Tyr Leu Lys
275 280 285
Pro Glu Lys Thr Ile Gln Glu Arg Leu Glu Ile Asn Arg Cys Glu Ala
290 295 300
Ile Asp Lys Thr Gln Asp Leu Leu Ala Gly Leu His Ala Arg Ser Asn
305 310 315 320
Lys Gln Thr Ser Leu Asn Arg Gly Thr Val Lys Leu Pro Pro Trp Leu
325 330 335
Pro Lys Pro Ser Ser Glu Ser Ile Asp Ile Lys Thr Asp Ser Gly Phe
340 345 350
Gly Ser Leu Met Asp His Gly Ala Tyr Gly Glu Leu Trp Ala Lys Cys
355 360 365
Leu Leu Asp Val Ser Leu Gly Asn Val Glu Gly Val Val Ser Asp Pro
370 375 380
Ala Lys Glu Leu Asp Ile Ala Ile Ser Asp Asp Pro Glu Lys Asp Thr
385 390 395 400
Pro Lys Glu Ala Lys Ile Thr Tyr Arg Arg Phe Lys Pro Ala Leu Ser
405 410 415
Ser Ser Ala Arg Gln Glu Phe Ser Leu Gln Gly Val Glu Gly Lys Lys
420 425 430
Trp Lys Arg Met Ala Ala Asn Gln Lys Lys Glu Lys Glu Ser His Glu
435 440 445
Ala Leu Ser Pro Phe Leu Asp Val Glu Asp Ile Gly Asp Phe Leu Thr
450 455 460
Phe Asn Asn Leu Leu Ala Asp Ser Arg Tyr Gly Asp Glu Ser Val Gln
465 470 475 480
Arg Ala Val Ser Ile Leu Leu Glu Lys Ala Ser Ala Met Gln Asp Thr
485 490 495
Glu Leu Thr His Ala Leu Asn Asp Ser Phe Lys Arg Asn Leu Ser Ser
500 505 510
Asn Val Val Gln Trp Ser Leu Trp Val Ser Cys Leu Ala Gln Glu Leu
515 520 525
Ala Ser Ala Leu Lys Gln His Cys Arg Ala Gly Glu Phe Ile Ile Lys
530 535 540
Lys Leu Lys Phe Trp Pro Ile Tyr Val Ile Ile Lys Pro Thr Lys Ser
545 550 555 560
Ser Ser His Ile Phe Tyr Ser Leu Gly Ile Arg Lys Ala Asp Val Thr
565 570 575
Arg Arg Leu Thr Gly Arg Val Phe Ser Asp Thr Ile Asp Ala Gly Glu
580 585 590
Trp Glu Leu Thr Glu Phe Lys Ser Leu Lys Thr Cys Lys Leu Thr Asn
595 600 605
Leu Val Asn Leu Pro Cys Thr Met Leu Asn Ser Ile Ala Phe Trp Arg
610 615 620
Glu Lys Leu Gly Val Ala Pro Trp Leu Val Arg Lys Pro Cys Ser Glu
625 630 635 640
Leu Arg Glu Gln Val Gly Leu Thr Phe Leu Ile Ser Leu Glu Asp Lys
645 650 655
Ser Lys Thr Glu Glu Ile Ile Thr Leu Thr Arg Tyr Thr Gln Met Glu
660 665 670
Gly Phe Val Ser Pro Pro Met Leu Pro Lys Pro Gln Lys Met Leu Gly
675 680 685
Lys Leu Asp Gly Pro Leu Arg Thr Lys Leu Gln Val Tyr Leu Leu Arg
690 695 700
Lys His Leu Asp Cys Met Val Arg Ile Ala Ser Gln Pro Phe Ser Leu
705 710 715 720
Ile Pro Arg Glu Gly Arg Val Glu Trp Gly Gly Thr Phe His Ala Ile
725 730 735
Ser Gly Arg Ser Thr Asn Leu Glu Asn Met Val Asn Ser Trp Tyr Ile
740 745 750
Gly Tyr Tyr Lys Asn Lys Glu Glu Ser Thr Glu Leu Asn Ala Leu Gly
755 760 765
Glu Met Tyr Lys Lys Ile Val Glu Met Glu Glu Asp Lys Pro Ser Ser
770 775 780
Pro Glu Phe Leu Gly Trp Gly Asp Thr Asp Ser Pro Lys Lys His Glu
785 790 795 800
Phe Ser Arg Ser Phe Leu Arg Ala Ala Cys Ser Ser Leu Glu Arg Glu
805 810 815
Ile Ala Gln Arg His Gly Arg Gln Trp Lys Gln Asn Leu Glu Glu Arg
820 825 830
Val Leu Arg Glu Ile Gly Thr Lys Asn Ile Leu Asp Leu Ala Ser Met
835 840 845
Lys Ala Thr Ser Asn Phe Ser Lys Asp Trp Glu Leu Tyr Ser Glu Val
850 855 860
Gln Thr Lys Glu Tyr His Arg Ser Lys Leu Leu Glu Lys Met Ala Thr
865 870 875 880
Leu Ile Glu Lys Gly Val Met Trp Tyr Ile Asp Ala Val Gly Gln Ala
885 890 895
Trp Lys Ala Val Leu Asp Asp Gly Cys Met Arg Ile Cys Leu Phe Lys
900 905 910
Lys Asn Gln His Gly Gly Leu Arg Glu Ile Tyr Val Met Asp Ala Asn
915 920 925
Ala Arg Leu Val Gln Phe Gly Val Glu Thr Met Ala Arg Cys Val Cys
930 935 940
Glu Leu Ser Pro His Glu Thr Val Ala Asn Pro Arg Leu Lys Asn Ser
945 950 955 960
Ile Ile Glu Asn His Gly Leu Lys Ser Ala Arg Ser Leu Gly Pro Gly
965 970 975
Ser Ile Asn Ile Asn Ser Ser Asn Asp Ala Lys Lys Trp Asn Gln Gly
980 985 990
His Tyr Thr Thr Lys Leu Ala Leu Val Leu Cys Trp Phe Met Pro Ala
995 1000 1005
Lys Phe His Arg Phe Ile Trp Ala Ala Ile Ser Met Phe Arg Arg Lys
1010 1015 1020
Lys Met Met Val Asp Leu Arg Phe Leu Ala His Leu Ser Ser Lys Ser
1025 1030 1035 1040
Glu Ser Arg Ser Ser Asp Pro Phe Arg Glu Ala Met Thr Asp Ala Phe
1045 1050 1055
His Gly Asn Arg Glu Val Ser Trp Met Asp Lys Gly Arg Thr Tyr Ile
1060 1065 1070
Lys Thr Glu Thr Gly Met Met Gln Gly Ile Leu His Phe Thr Ser Ser
1075 1080 1085
Leu Leu His Ser Cys Val Gln Ser Phe Tyr Lys Ser Tyr Phe Val Ser
1090 1095 1100
Lys Leu Lys Glu Gly Tyr Met Gly Glu Ser Ile Ser Gly Val Val Asp
1105 1110 1115 1120
Val Ile Glu Gly Ser Asp Asp Ser Ala Ile Met Ile Ser Ile Arg Pro
1125 1130 1135
Lys Ser Asp Met Asp Glu Val Arg Ser Arg Phe Phe Val Ala Asn Leu
1140 1145 1150
Leu His Ser Val Lys Phe Leu Asn Pro Leu Phe Gly Ile Tyr Ser Ser
1155 1160 1165
Glu Lys Ser Thr Val Asn Thr Val Tyr Cys Val Glu Tyr Asn Ser Glu
1170 1175 1180
Phe His Phe His Arg His Leu Val Arg Pro Thr Leu Arg Trp Ile Ala
1185 1190 1195 1200
Ala Ser His Gln Ile Ser Glu Thr Glu Ala Leu Ala Ser Arg Gln Glu
1205 1210 1215
Asp Tyr Ser Asn Leu Leu Thr Gln Cys Leu Glu Gly Gly Ala Ser Phe
1220 1225 1230
Ser Leu Thr Tyr Leu Ile Gln Cys Ala Gln Leu Leu His His Tyr Met
1235 1240 1245
Leu Leu Gly Leu Cys Leu His Pro Leu Phe Gly Thr Phe Met Gly Met
1250 1255 1260
Leu Ile Ser Asp Pro Asp Pro Ala Leu Gly Phe Phe Leu Met Asp Asn
1265 1270 1275 1280
Pro Ala Phe Ala Gly Gly Ala Gly Phe Arg Phe Asn Leu Trp Arg Ala
1285 1290 1295
Cys Lys Thr Thr Asp Leu Gly Arg Lys Tyr Ala Tyr Tyr Phe Asn Glu
1300 1305 1310
Ile Gln Gly Lys Thr Lys Gly Asp Glu Asp Tyr Arg Ala Leu Asp Ala
1315 1320 1325
Thr Ser Gly Gly Thr Leu Ser His Ser Val Met Val Tyr Trp Gly Asp
1330 1335 1340
Arg Lys Lys Tyr Gln Ala Leu Leu Ser Arg Met Gly Leu Pro Glu Asp
1345 1350 1355 1360
Trp Val Glu Gln Ile Asp Glu Asn Pro Gly Val Leu Tyr Arg Arg Ala
1365 1370 1375
Ala Asn Lys Lys Glu Leu Leu Leu Lys Leu Ala Glu Lys Val His Ser
1380 1385 1390
Pro Gly Val Thr Ser Ser Leu Ser Lys Gly His Val Val Pro Arg Val
1395 1400 1405
Val Ala Ala Gly Val Tyr Leu Leu Ser Arg His Cys Phe Arg Phe Ser
1410 1415 1420
Ser Ser Ile His Gly Arg Gly Ser Thr Gln Lys Ala Ser Leu Ile Lys
1425 1430 1435 1440
Leu Leu Met Met Ser Ser Ile Ser Ala Met Lys His Gly Gly Ser Leu
1445 1450 1455
Asn Pro Asn Gln Glu Arg Met Leu Phe Pro Gln Ala Gln Glu Tyr Asp
1460 1465 1470
Arg Val Cys Thr Leu Leu Glu Glu Val Glu His Leu Thr Gly Lys Phe
1475 1480 1485
Val Val Arg Glu Arg Asn Ile Val Arg Ser Arg Ile Asp Leu Phe Gln
1490 1495 1500
Glu Pro Val Asp Leu Arg Cys Lys Ala Glu Asp Leu Val Ser Glu Val
1505 1510 1515 1520
Trp Phe Gly Leu Lys Arg Thr Lys Leu Gly Pro Arg Leu Leu Lys Glu
1525 1530 1535
Glu Trp Asp Lys Leu Arg Ala Ser Phe Ala Trp Leu Ser Thr Asp Pro
1540 1545 1550
Ser Glu Thr Leu Arg Asp Gly Pro Phe Leu Ser His Val Gln Phe Arg
1555 1560 1565
Asn Phe Ile Ala His Val Asp Ala Lys Ser Arg Ser Val Arg Leu Leu
1570 1575 1580
Gly Ala Pro Val Lys Lys Ser Gly Gly Val Thr Thr Ile Ser Gln Val
1585 1590 1595 1600
Val Arg Met Asn Phe Phe Pro Gly Phe Ser Leu Glu Ala Glu Lys Ser
1605 1610 1615
Leu Asp Asn Gln Glu Arg Leu Glu Ser Ile Ser Ile Leu Lys His Val
1620 1625 1630
Leu Phe Met Val Leu Asn Gly Pro Tyr Thr Glu Glu Tyr Lys Leu Glu
1635 1640 1645
Met Ile Ile Glu Ala Phe Ser Thr Leu Val Ile Pro Gln Pro Ser Glu
1650 1655 1660
Val Ile Arg Lys Ser Arg Thr Met Thr Leu Cys Leu Leu Ser Asn Tyr
1665 1670 1675 1680
Leu Ser Ser Arg Gly Gly Ser Ile Leu Asp Gln Ile Glu Arg Ala Gln
1685 1690 1695
Ser Gly Thr Leu Gly Gly Phe Ser Lys Pro Gln Lys Thr Phe Ile Arg
1700 1705 1710
Pro Gly Gly Gly Val Gly Tyr Lys Gly Lys Gly Val Trp Thr Gly Val
1715 1720 1725
Met Glu Asp Thr His Val Gln Ile Leu Ile Asp Gly Asp Gly Thr Ser
1730 1735 1740
Asn Trp Leu Glu Glu Ile Arg Leu Ser Ser Asp Ala Arg Leu Tyr Asp
1745 1750 1755 1760
Val Ile Glu Ser Ile Arg Arg Leu Cys Asp Asp Leu Gly Ile Asn Asn
1765 1770 1775
Arg Val Ala Ser Ala Tyr Arg Gly His Cys Met Val Arg Leu Ser Gly
1780 1785 1790
Phe Lys Ile Lys Pro Ala Ser Arg Thr Asp Gly Cys Pro Val Arg Ile
1795 1800 1805
Met Glu Arg Gly Phe Arg Ile Arg Glu Leu Gln Asn Pro Asp Glu Val
1810 1815 1820
Lys Met Arg Val Arg Gly Asp Ile Leu Asn Leu Ser Val Thr Ile Gln
1825 1830 1835 1840
Glu Gly Arg Val Met Asn Ile Leu Ser Tyr Arg Pro Arg Asp Thr Asp
1845 1850 1855
Ile Ser Glu Ser Ala Ala Ala Tyr Leu Trp Ser Asn Arg Asp Leu Phe
1860 1865 1870
Ser Phe Gly Lys Lys Glu Pro Ser Cys Ser Trp Ile Cys Leu Lys Thr
1875 1880 1885
Leu Asp Asn Trp Ala Trp Ser His Ala Ser Val Leu Leu Ala Asn Asp
1890 1895 1900
Arg Lys Thr Gln Gly Ile Asp Asn Arg Ala Met Gly Asn Ile Phe Arg
1905 1910 1915 1920
Asp Cys Leu Glu Gly Ser Leu Arg Lys Gln Gly Leu Met Arg Ser Lys
1925 1930 1935
Leu Thr Glu Met Val Glu Lys Asn Val Val Pro Leu Thr Thr Gln Glu
1940 1945 1950
Leu Val Asp Ile Leu Glu Glu Asp Ile Asp Phe Ser Asp Val Ile Ala
1955 1960 1965
Val Glu Leu Ser Glu Gly Ser Leu Asp Ile Glu Ser Ile Phe Asp Gly
1970 1975 1980
Ala Pro Ile Leu Trp Ser Ala Glu Val Glu Glu Phe Gly Glu Gly Val
1985 1990 1995 2000
Val Ala Val Ser Tyr Ser Ser Lys Tyr Tyr His Leu Thr Leu Met Asp
2005 2010 2015
Gln Ala Ala Ile Thr Met Cys Ala Ile Met Gly Lys Glu Gly Cys Arg
2020 2025 2030
Gly Leu Leu Thr Glu Lys Arg Cys Met Ala Ala Ile Arg Glu Gln Val
2035 2040 2045
Arg Pro Phe Leu Ile Phe Leu Gln Ile Pro Glu Asp Ser Ile Ser Trp
2050 2055 2060
Val Ser Asp Gln Phe Cys Asp Ser Arg Gly Leu Asp Glu Glu Ser Thr
2065 2070 2075 2080
Ile Met Trp Gly ***
2085
<210> 10
<211> 1074
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type M
<400> 10
Met Met Lys Val Ile Trp Phe Ser Ser Leu Ile Cys Leu Val Ile Gln
1 5 10 15
Cys Gly Gly Asp Thr Gly Pro Ile Ile Cys Ala Gly Pro Ile His Ser
20 25 30
Asn Lys Ser Ala Asp Ile Pro His Leu Leu Gly Tyr Ser Glu Lys Ile
35 40 45
Cys Gln Ile Asp Arg Leu Ile His Val Ser Ser Trp Leu Arg Asn His
50 55 60
Ser Gln Phe Gln Gly Tyr Val Gly Gln Arg Gly Gly Arg Ser Gln Val
65 70 75 80
Ser Tyr Tyr Pro Ala Glu Asn Ser Tyr Ser Arg Trp Ser Gly Leu Leu
85 90 95
Ser Pro Cys Asp Ala Asp Trp Leu Gly Met Leu Val Val Lys Lys Ala
100 105 110
Lys Gly Ser Asp Met Ile Val Pro Gly Pro Ser Tyr Lys Gly Lys Val
115 120 125
Phe Phe Glu Arg Pro Thr Phe Asp Gly Tyr Val Gly Trp Gly Cys Gly
130 135 140
Ser Gly Lys Ser Arg Thr Glu Ser Gly Glu Leu Cys Ser Ser Asp Ser
145 150 155 160
Gly Thr Ser Ser Gly Leu Leu Pro Ser Asp Arg Val Leu Trp Ile Gly
165 170 175
Asp Val Ala Cys Gln Pro Met Thr Pro Ile Pro Glu Glu Thr Phe Leu
180 185 190
Glu Leu Lys Ser Phe Ser Gln Ser Glu Phe Pro Asp Ile Cys Lys Ile
195 200 205
Asp Gly Ile Val Phe Asn Gln Cys Glu Gly Glu Ser Leu Pro Gln Pro
210 215 220
Phe Asp Val Ala Trp Met Asp Val Gly His Ser His Lys Ile Ile Met
225 230 235 240
Arg Glu His Lys Thr Lys Trp Val Gln Glu Ser Ser Ser Lys Asp Phe
245 250 255
Val Cys Tyr Lys Glu Gly Thr Gly Pro Cys Ser Glu Ser Glu Glu Lys
260 265 270
Thr Cys Lys Thr Ser Gly Ser Cys Arg Gly Asp Met Gln Phe Cys Lys
275 280 285
Val Ala Gly Cys Glu His Gly Glu Glu Ala Ser Glu Ala Lys Cys Arg
290 295 300
Cys Ser Leu Val His Lys Pro Gly Glu Val Val Val Ser Tyr Gly Gly
305 310 315 320
Met Arg Val Arg Pro Lys Cys Tyr Gly Phe Ser Arg Met Met Ala Thr
325 330 335
Leu Glu Val Asn Glu Pro Glu Gln Arg Asn Gly Gln Cys Thr Gly Cys
340 345 350
His Leu Glu Cys Ile Asn Gly Gly Val Arg Leu Ile Thr Leu Thr Ser
355 360 365
Glu Leu Lys Ser Ala Thr Val Cys Ala Ser His Phe Cys Ser Ser Ala
370 375 380
Thr Ser Gly Lys Lys Ser Thr Glu Ile Gln Phe His Ser Gly Ser Leu
385 390 395 400
Val Gly Lys Thr Ala Ile His Val Lys Gly Ala Leu Val Asp Gly Thr
405 410 415
Glu Phe Thr Phe Glu Gly Ser Cys Met Phe Pro Asp Gly Cys Asp Ala
420 425 430
Val Asp Cys Thr Phe Cys Arg Glu Phe Leu Lys Asn Pro Gln Cys Tyr
435 440 445
Pro Ala Lys Lys Trp Leu Phe Ile Ile Ile Val Ile Leu Leu Gly Tyr
450 455 460
Ala Gly Leu Met Leu Leu Thr Asn Val Leu Lys Ala Ile Gly Val Trp
465 470 475 480
Gly Ser Trp Val Ile Ala Pro Val Lys Leu Val Phe Ala Ile Ile Lys
485 490 495
Lys Leu Met Arg Ala Val Ser Cys Leu Met Gly Lys Leu Met Asp Arg
500 505 510
Gly Arg Gln Val Ile His Glu Glu Ile Gly Glu Asn Arg Glu Gly Asn
515 520 525
Gln Asp Asp Val Arg Ile Glu Met Ala Arg Pro Arg Arg Val Arg His
530 535 540
Trp Met Tyr Ser Pro Val Ile Leu Thr Ile Leu Ala Met Gly Leu Ala
545 550 555 560
Glu Gly Cys Asp Glu Met Val His Ala Asp Ser Lys Leu Val Ser Cys
565 570 575
Arg Gln Gly Ser Gly Asn Met Lys Glu Cys Val Thr Thr Gly Arg Ala
580 585 590
Leu Leu Pro Ala Val Asn Pro Gly Gln Glu Ala Cys Leu His Phe Thr
595 600 605
Ala Pro Gly Ser Pro Asp Ser Lys Cys Leu Lys Ile Lys Val Lys Arg
610 615 620
Ile Asn Leu Lys Cys Lys Lys Ser Ser Ser Tyr Phe Val Pro Asp Ala
625 630 635 640
Arg Ser Arg Cys Thr Ser Val Arg Arg Cys Arg Trp Ala Gly Asp Cys
645 650 655
Gln Ser Gly Cys Pro Pro His Phe Thr Ser Asn Ser Phe Ser Asp Asp
660 665 670
Trp Ala Gly Lys Met Asp Arg Ala Gly Leu Gly Phe Ser Gly Cys Ser
675 680 685
Asp Gly Cys Gly Gly Ala Ala Cys Gly Cys Phe Asn Ala Ala Pro Ser
690 695 700
Cys Ile Phe Trp Arg Lys Trp Val Glu Asn Pro His Gly Ile Ile Trp
705 710 715 720
Lys Val Ser Pro Cys Ala Ala Trp Val Pro Ser Ala Val Ile Glu Leu
725 730 735
Thr Met Pro Ser Gly Glu Val Arg Thr Phe His Pro Met Ser Gly Ile
740 745 750
Pro Thr Gln Val Phe Lys Gly Val Ser Val Thr Tyr Leu Gly Ser Asp
755 760 765
Met Glu Val Ser Gly Leu Thr Asp Leu Cys Glu Ile Glu Glu Leu Lys
770 775 780
Ser Lys Lys Leu Ala Leu Ala Pro Cys Asn Gln Ala Gly Met Gly Val
785 790 795 800
Val Gly Lys Val Gly Glu Ile Gln Cys Ser Ser Glu Glu Ser Ala Arg
805 810 815
Thr Ile Lys Lys Asp Gly Cys Ile Trp Asn Ala Asp Leu Val Gly Ile
820 825 830
Glu Leu Arg Val Asp Asp Ala Val Cys Tyr Ser Lys Ile Thr Ser Val
835 840 845
Glu Ala Val Ala Asn Tyr Ser Ala Ile Pro Thr Thr Ile Gly Gly Leu
850 855 860
Arg Phe Glu Arg Ser His Asp Ser Gln Gly Lys Ile Ser Gly Ser Pro
865 870 875 880
Leu Asp Ile Thr Ala Ile Arg Gly Ser Phe Ser Ile Asn Tyr Arg Gly
885 890 895
Leu Arg Leu Ser Leu Ser Glu Ile Thr Ala Thr Cys Thr Gly Glu Val
900 905 910
Thr Asn Val Ser Gly Cys Tyr Ser Cys Met Thr Gly Ala Lys Val Ser
915 920 925
Ile Lys Leu His Ser Ser Lys Asn Ser Thr Ala His Val Arg Cys Lys
930 935 940
Gly Asp Glu Thr Ala Phe Ser Val Leu Glu Gly Val His Ser Tyr Ser
945 950 955 960
Val Ser Leu Ser Phe Asp His Ala Val Val Asp Glu Gln Cys Gln Leu
965 970 975
Asn Cys Gly Gly His Glu Ser Gln Val Thr Leu Arg Gly Asn Leu Ile
980 985 990
Phe Leu Asp Val Pro Lys Phe Val Asp Gly Ser Tyr Met Gln Thr Tyr
995 1000 1005
His Ser Thr Val Pro Thr Gly Ala Asn Ile Pro Ser Pro Thr Asp Trp
1010 1015 1020
Leu Asn Ala Leu Phe Gly Asn Gly Leu Ser Arg Trp Ile Leu Gly Val
1025 1030 1035 1040
Ile Gly Val Leu Leu Gly Gly Leu Ala Leu Phe Phe Leu Ile Met Ser
1045 1050 1055
Leu Phe Lys Leu Gly Thr Lys Gln Val Phe Arg Ser Arg Thr Lys Leu
1060 1065 1070
Ala ***
<210> 11
<211> 246
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type NP
<400> 11
Met Ser Glu Trp Ser Arg Ile Ala Val Glu Phe Gly Glu Gln Gln Leu
1 5 10 15
Asn Leu Thr Glu Leu Glu Asp Phe Ala Arg Glu Leu Ala Tyr Glu Gly
20 25 30
Leu Asp Pro Ala Leu Ile Ile Lys Lys Leu Lys Glu Thr Gly Gly Asp
35 40 45
Asp Trp Val Lys Asp Thr Lys Phe Ile Ile Val Phe Ala Leu Thr Arg
50 55 60
Gly Asn Lys Ile Val Lys Ala Ser Gly Lys Met Ser Asn Ser Gly Ser
65 70 75 80
Lys Arg Leu Met Ala Leu Gln Glu Lys Tyr Gly Leu Val Glu Arg Ala
85 90 95
Glu Thr Arg Leu Ser Ile Thr Pro Val Arg Val Ala Gln Ser Leu Pro
100 105 110
Thr Trp Thr Cys Ala Ala Ala Ala Ala Leu Lys Glu Tyr Leu Pro Val
115 120 125
Gly Pro Ala Val Met Asn Leu Lys Val Glu Asn Tyr Pro Pro Glu Met
130 135 140
Met Cys Met Ala Phe Gly Ser Leu Ile Pro Thr Ala Gly Val Ser Glu
145 150 155 160
Ala Thr Thr Lys Thr Leu Met Glu Ala Tyr Ser Leu Trp Gln Asp Ala
165 170 175
Phe Thr Lys Thr Ile Asn Val Lys Met Arg Gly Ala Ser Lys Thr Glu
180 185 190
Val Tyr Asn Ser Phe Arg Asp Pro Leu His Ala Ala Val Asn Ser Val
195 200 205
Phe Phe Pro Asn Asp Val Arg Val Lys Trp Leu Lys Ala Lys Gly Ile
210 215 220
Leu Gly Pro Asp Gly Val Pro Ser Arg Ala Ala Glu Val Ala Ala Ala
225 230 235 240
Ala Tyr Arg Asn Leu ***
245
<210> 12
<211> 294
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus A type NS
<400> 12
Met Ser Leu Ser Lys Cys Ser Asn Val Asp Leu Lys Ser Val Ala Met
1 5 10 15
Asn Ala Asn Thr Val Arg Leu Glu Pro Ser Leu Gly Glu Tyr Pro Thr
20 25 30
Leu Arg Arg Asp Leu Val Glu Cys Ser Cys Ser Val Leu Thr Leu Ser
35 40 45
Met Val Lys Arg Met Gly Lys Met Thr Asn Thr Val Trp Leu Phe Gly
50 55 60
Asn Pro Lys Asn Pro Leu His Gln Leu Glu Pro Gly Leu Glu Gln Leu
65 70 75 80
Leu Asp Met Tyr Tyr Lys Asp Met Arg Cys Tyr Ser Gln Arg Glu Leu
85 90 95
Ser Ala Leu Arg Trp Pro Ser Gly Lys Pro Ser Val Trp Phe Leu Gln
100 105 110
Ala Ala His Met Phe Phe Ser Ile Lys Asn Ser Trp Ala Met Glu Thr
115 120 125
Gly Arg Glu Asn Trp Arg Gly Leu Phe His Arg Ile Thr Lys Gly Gln
130 135 140
Lys Tyr Leu Phe Glu Gly Asp Met Ile Leu Asp Ser Leu Glu Ala Ile
145 150 155 160
Glu Lys Arg Arg Leu Arg Leu Gly Leu Pro Glu Ile Leu Ile Thr Gly
165 170 175
Leu Ser Pro Ile Leu Asp Val Ala Leu Leu Gln Ile Glu Ser Leu Ala
180 185 190
Arg Leu Arg Gly Met Ser Leu Asn His His Leu Phe Thr Ser Ser Ser
195 200 205
Leu Arg Lys Pro Leu Leu Asp Cys Trp Asp Phe Phe Ile Pro Ile Arg
210 215 220
Lys Lys Lys Thr Asp Gly Ser Tyr Ser Val Leu Asp Glu Asp Asp Glu
225 230 235 240
Pro Gly Val Leu Gln Gly Tyr Pro Tyr Leu Met Ala His Tyr Leu Asn
245 250 255
Arg Cys Pro Phe His Asn Leu Ile Arg Phe Asp Glu Glu Leu Arg Thr
260 265 270
Ala Ala Leu Asn Thr Ile Trp Gly Arg Asp Trp Pro Ala Ile Gly Asp
275 280 285
Leu Pro Lys Glu Val ***
290
<210> 13
<211> 2085
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type L
<400> 13
Met Asp Leu Glu Val Leu Cys Gly Arg Ile Asn Val Glu Asn Gly Leu
1 5 10 15
Ser Leu Gly Glu Pro Gly Leu Tyr Asp Gln Ile Tyr Asp Arg Pro Gly
20 25 30
Leu Pro Asp Leu Asp Val Thr Val Asp Ala Thr Gly Val Thr Val Asp
35 40 45
Ile Gly Ala Val Pro Asp Ser Ala Ser Gln Leu Gly Ser Ser Ile Asn
50 55 60
Ala Gly Leu Ile Thr Ile Gln Leu Ser Glu Ala Tyr Lys Ile Asn His
65 70 75 80
Asp Phe Thr Phe Ser Gly Leu Ser Lys Thr Thr Asp Arg Arg Leu Ser
85 90 95
Glu Val Phe Pro Ile Thr His Asp Gly Ser Asp Gly Met Thr Pro Asp
100 105 110
Val Ile His Thr Arg Leu Asp Gly Thr Ile Val Val Val Glu Phe Ser
115 120 125
Thr Thr Arg Ser His Asn Ile Gly Gly Leu Glu Ala Ala Tyr Arg Thr
130 135 140
Lys Ile Glu Lys Tyr Arg Asp Pro Ile Ser Arg Arg Val Asp Ile Met
145 150 155 160
Glu Asn Pro Arg Val Phe Phe Gly Val Ile Val Val Ser Ser Gly Gly
165 170 175
Val Leu Ser Asn Met Pro Leu Thr Gln Asp Glu Ala Glu Glu Leu Met
180 185 190
Tyr Arg Phe Cys Ile Ala Asn Glu Ile Tyr Thr Lys Ala Arg Ser Met
195 200 205
Asp Ala Asp Ile Glu Leu Gln Lys Ser Glu Glu Glu Leu Glu Ala Ile
210 215 220
Ser Arg Ala Leu Ser Phe Phe Ser Leu Phe Glu Pro Asn Ile Glu Arg
225 230 235 240
Val Glu Gly Thr Phe Pro Asn Ser Glu Ile Glu Met Leu Glu Gln Phe
245 250 255
Leu Ser Thr Pro Ala Asp Val Asp Phe Ile Thr Lys Thr Leu Lys Ala
260 265 270
Lys Glu Val Glu Ala Tyr Ala Asp Leu Cys Asp Ser His Tyr Leu Lys
275 280 285
Pro Glu Lys Thr Ile Gln Glu Arg Leu Glu Ile Asn Arg Cys Glu Ala
290 295 300
Ile Asp Lys Thr Gln Asp Leu Leu Ala Gly Leu His Ala Arg Ser Asn
305 310 315 320
Lys Gln Thr Ser Leu Asn Arg Gly Thr Val Lys Leu Pro Pro Trp Leu
325 330 335
Pro Lys Pro Ser Ser Glu Ser Ile Asp Ile Lys Thr Asp Ser Gly Phe
340 345 350
Gly Ser Leu Met Asp His Gly Ala Tyr Gly Glu Leu Trp Ala Lys Cys
355 360 365
Leu Leu Asp Val Ser Leu Gly Asn Val Glu Gly Val Val Ser Asp Pro
370 375 380
Ala Lys Glu Leu Asp Ile Ala Ile Ser Asp Asp Pro Glu Lys Asp Thr
385 390 395 400
Pro Lys Glu Ala Lys Ile Thr Tyr Arg Arg Phe Lys Pro Ala Leu Ser
405 410 415
Ser Ser Ala Arg Gln Glu Phe Ser Leu Gln Gly Val Glu Gly Lys Lys
420 425 430
Trp Lys Arg Met Ala Ala Asn Gln Lys Lys Glu Lys Glu Ser His Glu
435 440 445
Thr Leu Ser Pro Phe Leu Asp Val Asp Asp Ile Gly Asp Phe Leu Thr
450 455 460
Phe Asn Asn Leu Leu Ala Asp Ser Arg Tyr Gly Asp Glu Ser Ile Gln
465 470 475 480
Arg Ala Val Ser Ile Leu Leu Glu Lys Ala Ser Ala Met Gln Asp Thr
485 490 495
Glu Leu Thr His Ala Leu Asn Asp Ser Phe Lys Arg Asn Leu Ser Ser
500 505 510
Asn Val Val Gln Trp Ser Leu Trp Val Ser Cys Leu Ala Gln Glu Leu
515 520 525
Ala Ser Ala Leu Lys Gln His Cys Arg Ala Gly Glu Phe Ile Ile Lys
530 535 540
Lys Leu Lys Phe Trp Pro Ile Tyr Val Ile Ile Lys Pro Thr Lys Ser
545 550 555 560
Ser Ser His Ile Phe Tyr Ser Leu Gly Ile Arg Lys Ala Asp Val Thr
565 570 575
Arg Arg Leu Thr Gly Arg Val Phe Ser Asp Thr Ile Asp Ala Gly Glu
580 585 590
Trp Glu Leu Thr Glu Phe Lys Ser Leu Lys Thr Cys Lys Leu Thr Asn
595 600 605
Leu Val Asn Leu Pro Cys Thr Met Leu Asn Ser Ile Ala Phe Trp Arg
610 615 620
Glu Lys Leu Gly Val Ala Pro Trp Leu Val Arg Lys Pro Cys Ser Glu
625 630 635 640
Leu Arg Glu Gln Val Gly Leu Thr Phe Leu Val Ser Leu Glu Asp Lys
645 650 655
Ser Lys Thr Glu Glu Ile Ile Thr Leu Thr Arg Tyr Thr Gln Met Glu
660 665 670
Gly Phe Val Ser Pro Pro Met Leu Pro Lys Pro Gln Lys Met Leu Gly
675 680 685
Lys Leu Glu Gly Pro Leu Arg Thr Lys Leu Gln Val Tyr Leu Leu Arg
690 695 700
Lys His Leu Asp Cys Met Val Arg Ile Ala Ser Gln Pro Phe Ser Leu
705 710 715 720
Ile Pro Arg Glu Gly Arg Val Glu Trp Gly Gly Thr Phe His Ala Ile
725 730 735
Ser Gly Arg Ser Thr Asn Leu Glu Asn Met Val Asn Ser Trp Tyr Ile
740 745 750
Gly Tyr Tyr Lys Asn Lys Glu Glu Ser Thr Glu Leu Asn Ala Leu Gly
755 760 765
Glu Met Tyr Lys Lys Ile Val Glu Met Glu Glu Asp Lys Pro Ser Ser
770 775 780
Pro Glu Phe Leu Gly Trp Gly Asp Thr Asp Ser Pro Lys Lys His Glu
785 790 795 800
Phe Ser Arg Ser Phe Leu Arg Ala Ala Cys Ser Ser Leu Glu Arg Glu
805 810 815
Ile Ala Gln Arg His Gly Arg Gln Trp Lys Gln Asn Leu Glu Glu Arg
820 825 830
Val Leu Arg Glu Ile Gly Ala Lys Asn Ile Leu Asp Leu Ala Ser Met
835 840 845
Lys Ala Thr Ser Asn Phe Ser Lys Asp Trp Glu Leu Tyr Ser Glu Val
850 855 860
Gln Thr Lys Glu Tyr His Arg Ser Lys Leu Leu Glu Lys Met Ala Thr
865 870 875 880
Leu Ile Glu Lys Gly Val Met Trp Tyr Ile Asp Ala Val Gly Gln Ala
885 890 895
Trp Lys Ala Val Leu Asp Asp Gly Cys Met Arg Ile Cys Leu Phe Lys
900 905 910
Lys Asn Gln His Gly Gly Leu Arg Glu Ile Tyr Val Met Asp Ala Asn
915 920 925
Ala Arg Leu Val Gln Phe Gly Val Glu Thr Met Ala Arg Cys Val Cys
930 935 940
Glu Leu Ser Pro His Glu Thr Val Ala Asn Pro Arg Leu Lys Asn Ser
945 950 955 960
Ile Ile Glu Asn His Gly Leu Lys Ser Ala Arg Ser Leu Gly Pro Gly
965 970 975
Ser Ile Asn Ile Asn Ser Ser Asn Asp Ala Lys Lys Trp Asn Gln Gly
980 985 990
His Tyr Thr Thr Lys Leu Ala Leu Val Leu Cys Trp Phe Met Pro Ala
995 1000 1005
Lys Phe His Arg Phe Ile Trp Ala Ala Ile Ser Met Phe Arg Arg Lys
1010 1015 1020
Lys Met Met Val Asp Leu Arg Phe Leu Ala His Leu Ser Ser Lys Ser
1025 1030 1035 1040
Glu Ser Arg Ser Ser Asp Pro Phe Arg Glu Ala Met Thr Asp Ala Phe
1045 1050 1055
His Gly Asn Arg Asp Val Ser Trp Met Asp Lys Gly Arg Thr Tyr Ile
1060 1065 1070
Lys Thr Glu Thr Gly Met Met Gln Gly Ile Leu His Phe Thr Ser Ser
1075 1080 1085
Leu Leu His Ser Cys Val Gln Ser Phe Tyr Lys Ser Tyr Phe Val Ser
1090 1095 1100
Lys Leu Lys Glu Gly Tyr Met Gly Glu Ser Ile Ser Gly Val Val Asp
1105 1110 1115 1120
Val Ile Glu Gly Ser Asp Asp Ser Ala Ile Met Ile Ser Ile Arg Pro
1125 1130 1135
Lys Ser Asp Met Asp Glu Val Arg Ser Arg Phe Phe Val Ala Asn Leu
1140 1145 1150
Leu His Ser Val Lys Phe Leu Asn Pro Leu Phe Gly Ile Tyr Ser Ser
1155 1160 1165
Glu Lys Ser Thr Val Asn Thr Val Tyr Cys Val Glu Tyr Asn Ser Glu
1170 1175 1180
Phe His Phe His Arg His Leu Val Arg Pro Thr Leu Arg Trp Ile Ala
1185 1190 1195 1200
Ala Ser His Gln Ile Ser Glu Thr Glu Ala Leu Ala Ser Arg Gln Glu
1205 1210 1215
Asp Tyr Ser Asn Leu Leu Thr Gln Cys Leu Glu Gly Gly Ala Ser Phe
1220 1225 1230
Ser Leu Thr Tyr Leu Ile Gln Cys Ala Gln Leu Leu His His Tyr Met
1235 1240 1245
Leu Leu Gly Leu Cys Leu His Pro Leu Phe Gly Thr Phe Met Gly Met
1250 1255 1260
Leu Ile Ser Asp Pro Asp Pro Ala Leu Gly Phe Phe Leu Met Asp Asn
1265 1270 1275 1280
Pro Ala Phe Ala Gly Gly Ala Gly Phe Arg Phe Asn Leu Trp Arg Ala
1285 1290 1295
Cys Lys Thr Thr Asp Leu Gly Arg Lys Tyr Ala Tyr Tyr Phe Asn Glu
1300 1305 1310
Ile Gln Gly Lys Thr Lys Gly Asp Glu Asp Tyr Arg Ala Leu Asp Ala
1315 1320 1325
Thr Ser Gly Gly Thr Leu Ser His Ser Val Met Val Tyr Trp Gly Asp
1330 1335 1340
Arg Lys Lys Tyr Gln Ala Leu Leu Asn Arg Met Gly Leu Pro Glu Asp
1345 1350 1355 1360
Trp Val Glu Gln Ile Asp Glu Asn Pro Gly Val Leu Tyr Arg Arg Ala
1365 1370 1375
Ala Asn Lys Lys Glu Leu Leu Leu Lys Leu Ala Glu Lys Val His Ser
1380 1385 1390
Pro Gly Val Thr Ser Ser Leu Ser Lys Gly His Val Val Pro Arg Val
1395 1400 1405
Val Ala Ala Gly Val Tyr Leu Leu Ser Arg His Cys Phe Arg Phe Ser
1410 1415 1420
Ser Ser Ile His Gly Arg Gly Ser Thr Gln Lys Ala Ser Leu Ile Lys
1425 1430 1435 1440
Leu Leu Met Met Ser Ser Ile Ser Ala Met Lys His Gly Gly Ser Leu
1445 1450 1455
Asn Pro Asn Gln Glu Arg Met Leu Phe Pro Gln Ala Gln Glu Tyr Asp
1460 1465 1470
Arg Val Cys Thr Leu Leu Glu Glu Val Glu His Leu Thr Gly Lys Phe
1475 1480 1485
Val Val Arg Glu Arg Asn Ile Val Arg Ser Arg Ile Asp Leu Phe Gln
1490 1495 1500
Glu Pro Val Asp Leu Arg Cys Lys Ala Glu Asp Leu Val Ser Glu Val
1505 1510 1515 1520
Trp Phe Gly Leu Lys Arg Thr Lys Leu Gly Pro Arg Leu Leu Lys Glu
1525 1530 1535
Glu Trp Asp Lys Leu Arg Ala Ser Phe Ala Trp Leu Ser Thr Asp Pro
1540 1545 1550
Ser Glu Thr Leu Arg Asp Gly Pro Phe Leu Ser His Val Gln Phe Arg
1555 1560 1565
Asn Phe Ile Ala His Val Asp Ala Lys Ser Arg Ser Val Arg Leu Leu
1570 1575 1580
Gly Ala Pro Val Lys Lys Ser Gly Gly Val Thr Thr Ile Ser Gln Val
1585 1590 1595 1600
Val Arg Met Asn Phe Phe Pro Gly Phe Ser Leu Glu Ala Glu Lys Ser
1605 1610 1615
Leu Asp Asn Gln Glu Arg Leu Glu Ser Ile Ser Ile Leu Lys His Val
1620 1625 1630
Leu Phe Met Val Leu Asn Gly Pro Tyr Thr Glu Glu Tyr Lys Leu Glu
1635 1640 1645
Met Ile Ile Glu Ala Phe Ser Thr Leu Val Ile Pro Gln Pro Ser Glu
1650 1655 1660
Val Ile Arg Lys Ser Arg Thr Met Thr Leu Cys Leu Leu Ser Asn Tyr
1665 1670 1675 1680
Leu Ser Ser Arg Gly Gly Ser Ile Leu Asp Gln Ile Glu Arg Ala Gln
1685 1690 1695
Ser Gly Thr Leu Gly Gly Phe Ser Lys Pro Gln Lys Thr Phe Ile Arg
1700 1705 1710
Pro Gly Gly Gly Val Gly Tyr Lys Gly Lys Gly Val Trp Thr Gly Val
1715 1720 1725
Met Glu Asp Thr His Val Gln Ile Leu Ile Asp Gly Asp Gly Thr Ser
1730 1735 1740
Asn Trp Leu Glu Glu Ile Arg Leu Ser Ser Asp Ala Arg Leu Tyr Asp
1745 1750 1755 1760
Val Ile Glu Ser Ile Arg Arg Leu Cys Asp Asp Leu Gly Ile Asn Asn
1765 1770 1775
Arg Val Ala Ser Ala Tyr Arg Gly His Cys Met Val Arg Leu Ser Gly
1780 1785 1790
Phe Lys Ile Lys Pro Ala Ser Arg Thr Asp Gly Cys Pro Val Arg Ile
1795 1800 1805
Met Glu Arg Gly Phe Arg Ile Arg Glu Leu Gln Asn Pro Asp Glu Val
1810 1815 1820
Lys Met Arg Val Arg Gly Asp Ile Leu Asn Leu Ser Val Thr Ile Gln
1825 1830 1835 1840
Glu Gly Arg Val Met Asn Ile Leu Ser Tyr Arg Pro Arg Asp Thr Asp
1845 1850 1855
Ile Ser Glu Ser Ala Ala Ala Tyr Leu Trp Ser Asn Arg Asp Leu Phe
1860 1865 1870
Ser Phe Gly Lys Lys Glu Pro Ser Cys Ser Trp Ile Cys Leu Lys Thr
1875 1880 1885
Leu Asp Asn Trp Ala Trp Ser His Ala Ser Val Leu Leu Ala Asn Asp
1890 1895 1900
Arg Lys Thr Gln Gly Ile Asp Asn Arg Ala Met Gly Asn Ile Phe Arg
1905 1910 1915 1920
Asp Cys Leu Glu Gly Ser Leu Arg Lys Gln Gly Leu Met Arg Ser Lys
1925 1930 1935
Leu Thr Glu Met Val Glu Lys Asn Val Val Pro Leu Thr Thr Gln Glu
1940 1945 1950
Leu Val Asp Ile Leu Glu Glu Asp Ile Asp Phe Ser Asp Val Ile Ala
1955 1960 1965
Val Glu Leu Ser Glu Gly Ser Leu Asp Ile Glu Ser Ile Phe Asp Gly
1970 1975 1980
Ala Pro Ile Leu Trp Ser Ala Glu Val Glu Glu Phe Gly Glu Gly Val
1985 1990 1995 2000
Val Ala Val Ser Tyr Ser Ser Lys Tyr Tyr His Leu Thr Leu Met Asp
2005 2010 2015
Gln Ala Ala Ile Thr Met Cys Ala Ile Met Gly Lys Glu Gly Cys Arg
2020 2025 2030
Gly Leu Leu Thr Glu Lys Arg Cys Met Ala Ala Ile Arg Glu Gln Val
2035 2040 2045
Arg Pro Phe Leu Ile Phe Leu Gln Ile Pro Glu Asp Ser Ile Ser Trp
2050 2055 2060
Val Ser Asp Gln Phe Cys Asp Ser Arg Gly Leu Asp Glu Glu Ser Thr
2065 2070 2075 2080
Ile Met Trp Gly ***
2085
<210> 14
<211> 1074
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type M
<400> 14
Met Met Lys Val Ile Trp Phe Ser Ser Leu Ile Cys Phe Val Ile Gln
1 5 10 15
Cys Ser Gly Asp Ser Gly Pro Ile Ile Cys Ala Gly Pro Ile His Ser
20 25 30
Asn Lys Ser Ala Asp Ile Pro His Leu Leu Gly Tyr Ser Glu Lys Ile
35 40 45
Cys Gln Ile Asp Arg Leu Ile His Val Ser Ser Trp Leu Arg Asn His
50 55 60
Ser Gln Phe Gln Gly Tyr Val Gly Gln Arg Gly Gly Arg Ser Gln Val
65 70 75 80
Ser Tyr Tyr Pro Ala Glu Asn Ser Tyr Ser Arg Trp Ser Gly Leu Leu
85 90 95
Ser Pro Cys Asp Ala Asp Trp Leu Gly Met Leu Val Val Lys Lys Ala
100 105 110
Lys Gly Ser Asp Met Ile Val Pro Gly Pro Ser Tyr Lys Gly Lys Val
115 120 125
Phe Phe Glu Arg Pro Thr Phe Asp Gly Tyr Val Gly Trp Gly Cys Gly
130 135 140
Ser Gly Lys Ser Arg Thr Glu Ser Gly Glu Leu Cys Ser Ser Asp Ser
145 150 155 160
Gly Thr Ser Ser Gly Leu Leu Pro Ser Asp Arg Val Leu Trp Ile Gly
165 170 175
Asp Val Ala Cys Gln Pro Met Thr Pro Ile Pro Glu Glu Thr Phe Leu
180 185 190
Glu Leu Lys Ser Phe Ser Gln Ser Glu Phe Pro Asp Ile Cys Lys Ile
195 200 205
Asp Gly Ile Val Phe Asn Gln Cys Glu Gly Glu Ser Leu Pro Gln Pro
210 215 220
Phe Asp Val Ala Trp Met Asp Val Gly His Ser His Lys Ile Ile Met
225 230 235 240
Arg Glu His Lys Thr Lys Trp Val Gln Glu Ser Ser Ser Lys Asp Phe
245 250 255
Val Cys Tyr Lys Glu Gly Thr Gly Pro Cys Ser Glu Ser Glu Glu Lys
260 265 270
Thr Cys Lys Thr Ser Gly Ser Cys Arg Gly Asp Met Gln Phe Cys Lys
275 280 285
Val Ala Gly Cys Glu His Gly Glu Glu Ala Ser Glu Ala Lys Cys Arg
290 295 300
Cys Ser Leu Val His Lys Pro Gly Glu Val Val Val Ser Tyr Gly Gly
305 310 315 320
Met Arg Val Arg Pro Lys Cys Tyr Gly Phe Ser Arg Met Met Ala Thr
325 330 335
Leu Glu Val Asn Gln Pro Glu Gln Arg Ile Gly Gln Cys Thr Gly Cys
340 345 350
His Leu Glu Cys Ile Asn Gly Gly Val Arg Leu Ile Thr Leu Thr Ser
355 360 365
Glu Leu Lys Ser Ala Thr Val Cys Ala Ser His Phe Cys Ser Ser Ala
370 375 380
Thr Ser Gly Lys Lys Ser Thr Glu Ile Gln Phe His Ser Gly Ser Leu
385 390 395 400
Val Gly Lys Thr Ala Ile His Val Lys Gly Ala Leu Val Asp Gly Thr
405 410 415
Glu Phe Thr Phe Glu Gly Ser Cys Met Phe Pro Asp Gly Cys Asp Ala
420 425 430
Val Asp Cys Thr Phe Cys Arg Glu Phe Leu Lys Asn Pro Gln Cys Tyr
435 440 445
Pro Ala Lys Lys Trp Leu Phe Ile Ile Ile Val Ile Leu Leu Gly Tyr
450 455 460
Ala Gly Leu Met Leu Leu Thr Asn Val Leu Lys Ala Ile Gly Ile Trp
465 470 475 480
Gly Ser Trp Val Ile Ala Pro Val Lys Leu Ile Phe Ala Ile Ile Lys
485 490 495
Lys Leu Met Arg Thr Val Ser Cys Leu Met Gly Lys Leu Met Asp Arg
500 505 510
Gly Arg Gln Val Ile His Glu Glu Ile Gly Glu Asn Arg Glu Gly Asn
515 520 525
Gln Asp Asp Val Arg Ile Glu Met Ala Arg Pro Arg Arg Val Arg His
530 535 540
Trp Met Tyr Ser Pro Val Ile Leu Thr Ile Leu Ala Ile Gly Leu Ala
545 550 555 560
Glu Ser Cys Asp Glu Met Val His Ala Asp Ser Lys Leu Val Ser Cys
565 570 575
Arg Gln Gly Ser Gly Asn Met Lys Glu Cys Val Thr Thr Gly Arg Ala
580 585 590
Leu Leu Pro Ala Val Asn Pro Gly Gln Glu Ala Cys Leu His Phe Thr
595 600 605
Ala Pro Gly Ser Pro Asp Ser Lys Cys Leu Lys Ile Lys Val Lys Arg
610 615 620
Ile Asn Leu Lys Cys Lys Lys Ser Ser Ser Tyr Phe Val Pro Asp Ala
625 630 635 640
Arg Ser Arg Cys Thr Ser Val Arg Arg Cys Arg Trp Ala Gly Asp Cys
645 650 655
Gln Ser Gly Cys Pro Pro His Phe Thr Ser Asn Ser Phe Ser Asp Asp
660 665 670
Trp Ala Gly Lys Met Asp Arg Ala Gly Leu Gly Phe Ser Gly Cys Ser
675 680 685
Asp Gly Cys Gly Gly Ala Ala Cys Gly Cys Phe Asn Ala Ala Pro Ser
690 695 700
Cys Ile Phe Trp Arg Lys Trp Val Glu Asn Pro His Gly Ile Ile Trp
705 710 715 720
Lys Val Ser Pro Cys Ala Ala Trp Val Pro Ser Ala Val Ile Glu Leu
725 730 735
Thr Met Pro Ser Gly Glu Val Arg Thr Phe His Pro Met Ser Gly Ile
740 745 750
Pro Thr Gln Val Phe Lys Gly Val Ser Val Thr Tyr Leu Gly Ser Asp
755 760 765
Met Glu Val Ser Gly Leu Thr Asp Leu Cys Glu Ile Glu Glu Leu Lys
770 775 780
Ser Lys Lys Leu Ala Leu Ala Pro Cys Asn Gln Ala Gly Met Gly Val
785 790 795 800
Val Gly Lys Val Gly Glu Ile Gln Cys Ser Ser Glu Glu Ser Ala Arg
805 810 815
Thr Ile Lys Lys Asp Gly Cys Ile Trp Asn Ala Asp Leu Val Gly Ile
820 825 830
Glu Leu Arg Val Asp Asp Ala Val Cys Tyr Ser Lys Ile Thr Ser Val
835 840 845
Glu Ala Val Ala Asn Tyr Ser Ala Ile Pro Thr Thr Ile Gly Gly Leu
850 855 860
Arg Phe Glu Arg Ser His Asp Ser Gln Gly Lys Ile Ser Gly Ser Pro
865 870 875 880
Leu Asp Ile Thr Ala Ile Arg Gly Ser Phe Ser Val Asn Tyr Arg Gly
885 890 895
Leu Arg Leu Ser Leu Ser Glu Ile Thr Ala Thr Cys Thr Gly Glu Val
900 905 910
Thr Asn Val Ser Gly Cys Tyr Ser Cys Met Thr Gly Ala Lys Val Ser
915 920 925
Ile Lys Leu His Ser Ser Lys Asn Ser Thr Ala His Val Arg Cys Lys
930 935 940
Gly Asp Glu Thr Ala Phe Ser Val Leu Glu Gly Val His Ser Tyr Thr
945 950 955 960
Val Asn Leu Ser Phe Asp His Ala Val Val Asp Glu Gln Cys Gln Leu
965 970 975
Asn Cys Gly Gly His Glu Ser Gln Val Thr Leu Lys Gly Asn Leu Ile
980 985 990
Phe Leu Asp Val Pro Lys Phe Val Asp Gly Ser Tyr Met Gln Thr Tyr
995 1000 1005
His Ser Thr Val Pro Thr Gly Ala Asn Ile Pro Ser Pro Thr Asp Trp
1010 1015 1020
Leu Asn Ala Leu Phe Gly Asn Gly Leu Ser Arg Trp Ile Leu Gly Val
1025 1030 1035 1040
Ile Gly Val Leu Leu Gly Gly Leu Ala Leu Phe Phe Met Ile Met Ser
1045 1050 1055
Leu Phe Lys Leu Gly Thr Lys Gln Val Phe Arg Ser Arg Thr Lys Leu
1060 1065 1070
Ala ***
<210> 15
<211> 246
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type NP
<400> 15
Met Ser Glu Trp Ser Arg Ile Ala Val Glu Phe Gly Glu Gln Gln Leu
1 5 10 15
Asn Leu Thr Glu Leu Glu Asp Phe Ala Arg Glu Leu Ala Tyr Glu Gly
20 25 30
Leu Asp Pro Ala Leu Ile Ile Lys Lys Leu Lys Glu Thr Gly Gly Asp
35 40 45
Asp Trp Val Lys Asp Thr Lys Phe Ile Ile Val Phe Ala Leu Thr Arg
50 55 60
Gly Asn Lys Ile Val Lys Ala Ser Gly Lys Met Ser Asn Ser Gly Ser
65 70 75 80
Lys Arg Leu Met Ala Leu Gln Glu Lys Tyr Gly Leu Val Glu Arg Ala
85 90 95
Glu Thr Arg Leu Ser Ile Thr Pro Val Arg Val Ala Gln Ser Leu Pro
100 105 110
Thr Trp Thr Cys Ala Ala Ala Ala Ala Leu Lys Glu Tyr Leu Pro Val
115 120 125
Gly Pro Ala Val Met Asn Leu Lys Val Glu Asn Tyr Pro Pro Glu Met
130 135 140
Met Cys Met Ala Phe Gly Ser Leu Ile Pro Thr Ala Gly Val Ser Glu
145 150 155 160
Ala Thr Thr Lys Thr Leu Met Glu Ala Tyr Ser Leu Trp Gln Asp Ala
165 170 175
Phe Thr Lys Thr Ile Asn Val Lys Met Arg Gly Ala Ser Lys Thr Glu
180 185 190
Val Tyr Asn Ser Phe Arg Asp Pro Leu His Ala Ala Val Asn Ser Val
195 200 205
Phe Phe Pro Asn Asp Val Arg Val Lys Trp Leu Lys Ala Lys Gly Ile
210 215 220
Leu Gly Pro Asp Gly Val Pro Ser Arg Ala Ala Glu Val Ala Ala Ala
225 230 235 240
Ala Tyr Arg Asn Leu ***
245
<210> 16
<211> 294
<212> PRT
<213> Unknown
<220>
<223> severe fever thrombocytopenia syndrome virus F type NS
<400> 16
Met Ser Leu Ser Lys Cys Ser Asn Val Asp Leu Lys Ser Val Ala Met
1 5 10 15
Asn Ala Asn Thr Val Arg Leu Glu Pro Ser Leu Gly Glu Tyr Pro Thr
20 25 30
Leu Arg Arg Asp Leu Val Glu Cys Ser Cys Ser Val Leu Thr Leu Ser
35 40 45
Met Val Lys Arg Met Gly Lys Met Thr Asn Thr Val Trp Leu Phe Gly
50 55 60
Asn Pro Lys Asn Pro Leu His Gln Leu Glu Pro Gly Leu Glu Gln Leu
65 70 75 80
Leu Asp Met Tyr Tyr Lys Asp Met Arg Cys Tyr Ser Gln Arg Glu Leu
85 90 95
Ser Ala Leu Arg Trp Pro Ser Gly Lys Pro Ser Val Trp Phe Leu Gln
100 105 110
Ala Ala His Met Phe Phe Ser Ile Lys Asn Ser Trp Ala Met Glu Thr
115 120 125
Gly Arg Glu Asn Trp Arg Gly Leu Phe His Arg Ile Thr Lys Gly Arg
130 135 140
Arg Tyr Leu Phe Glu Gly Asp Met Ile Leu Asp Ser Leu Glu Ala Ile
145 150 155 160
Glu Lys Arg Arg Leu Arg Leu Gly Leu Pro Asp Ile Leu Ile Thr Gly
165 170 175
Leu Ser Pro Ile Leu Asp Val Ala Leu Leu Gln Ile Glu Ser Leu Ala
180 185 190
Arg Leu Arg Gly Met Ser Leu Asn His His Leu Phe Thr Ser Ser Ser
195 200 205
Leu Arg Lys Pro Leu Leu Asp Cys Trp Asp Phe Phe Ile Pro Ile Arg
210 215 220
Lys Lys Lys Thr Asp Gly Ser Tyr Ser Val Leu Asp Glu Asp Asp Glu
225 230 235 240
Pro Gly Val Leu Gln Gly Tyr Pro Tyr Leu Met Ala His Tyr Leu Asn
245 250 255
Arg Cys Pro Phe His Asn Leu Ile Arg Phe Asp Glu Glu Leu Arg Thr
260 265 270
Ala Ala Leu Asn Thr Ile Trp Gly Arg Asp Trp Pro Ala Ile Gly Asp
275 280 285
Pro Pro Lys Glu Val ***
290
Claims (13)
- L 유전자의 ORF (6255bp)에서 발현된 단백질의 1061번 아미노산이 아스파르트산이고, M 유전자의 ORF (3222bp)에서 발현된 단백질의 18번째 아미노산이 세린, 562번째 아미노산이 세린, 960번째 아미노산이 트레오닌, 988번째 아미노산이 라이신 및 1053번째 아미노산이 메티오닌이며, S 유전자의 ORF (1674bp)에서 발현된 단백질 NS(294aa)의 145번째 아미노산이 아르기닌 및 171번째 아미노산이 아스파르트산이고; 상기에서, L 유전자의 ORF (6255bp)에서 발현된 단백질이 서열번호 13의 아미노산 서열로 이루어지고, M 유전자의 ORF (3222bp)에서 발현된 단백질이 서열번호 14의 아미노산 서열로 이루어지며, S 유전자의 ORF (1674bp)에서 발현된 단백질 NS(294aa)가 서열번호 16의 아미노산 서열로 이루어진, 중증열성 혈소판 감소증 바이러스(severe fever thrombocytopenia syndrome virus, SFTSV).
- 제 1항에 있어서, 서열번호 5의 염기서열로 이루어진 L 유전자, 서열번호 6의 염기서열로 이루어진 M 유전자, 서열번호 7의 염기서열로 이루어진 S(NP) 유전자 및 서열번호 8의 염기서열로 이루어진 S(NS) 유전자를 포함하는, 중증열성 혈소판 감소증 바이러스.
- 삭제
- 삭제
- 제 1항의 중증열성 혈소판 감소증 바이러스를 유효성분으로 포함하는, 중증열성 혈소판 감소증의 예방 또는 치료용 면역원성 조성물.
- 제 5항에 있어서, 불활화한 중증열성 혈소판 감소증 바이러스와 약제학적으로 수용가능한 담체 (carrier) 또는 아쥬반트(adjuvant)를 포함하는, 중증열성 혈소판 감소증의 예방 또는 치료용 면역원성 조성물.
- 제 5항에 있어서, 상기 면역원성 조성물의 형태는 생독 백신, 사독 백신, 약독화된 중증열성 혈소판 감소증 바이러스의 유전자를 사용하여 생산한 서브유니트 백신, 벡터 백신, 키메라 백신, DNA 및 RNA 백신으로 구성된 군으로부터 선택되는, 중증열성 혈소판 감소증의 예방 또는 치료용 면역원성 조성물.
- 제 5항에 있어서, 서열번호 1의 염기서열로 이루어진 L 유전자, 서열번호 2의 염기서열로 이루어진 M 유전자, 서열번호 3의 염기서열로 이루어진 S(NP) 유전자 및 서열번호 4의 염기서열로 이루어진 S(NS) 유전자를 포함하는 중증열성 혈소판 감소증 바이러스; 및 서열번호 5의 염기서열로 이루어진 L 유전자, 서열번호 6의 염기서열로 이루어진 M 유전자, 서열번호 7의 염기서열로 이루어진 S(NP) 유전자 및 서열번호 8의 염기서열로 이루어진 S(NS) 유전자를 포함하는 중증열성 혈소판 감소증 바이러스들을 유효성분으로 포함하는, 중증열성 혈소판 감소증의 예방 또는 치료용 면역원성 조성물.
- 제 1항의 바이러스를 가지고 면역화에 반응하여 생산된 항체.
- 제 1항의 바이러스를 포함하는 중증열성 혈소판 감소증 바이러스의 진단 키트.
- (a) 항원-항체 복합체가 형성될 수 있는 조건하에서 검체로부터 분리된 시료를 제 1항의 바이러스와 접촉시키는 단계; 및
(b) 항원-항체 복합체 형성을 검출하는 단계를 포함하는, 중증열성 혈소판 감소증 바이러스 항체를 검출하는 방법. - (a) 제 1항의 바이러스를 면역반응을 유도하기에 유효한 양으로 사람이 아닌 동물에게 투여하는 단계; 및
(b) 상기 중증열성 혈소판 감소증 바이러스에 대한 항체를 함유하는 항혈청 또는 혈장을 수집하는 단계를 포함하는, 사람이 아닌 동물에서 중증열성 혈소판 감소증 바이러스에 대한 항혈청을 생산하는 방법. - (a) 검체로부터 분리된 시료를 제 1항의 바이러스와 접촉시켜 항원-항체 복합체를 형성시키는 단계; 및
(b) 상기 복합체의 형성을 검출하는 단계를 포함하는, 중증열성 혈소판 감소증 진단에 관한 정보를 제공하는 방법.
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Non-Patent Citations (2)
Title |
---|
FTLS virus isolate 2012YSH37 glycoprotein gene, complete cds, GenBank: KF711936.1, 2014.03.21. |
Huaiyangshan virus strain L-WJ segment L, complete sequence, GenBank: HQ171186.1, 2011.04.02. |
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Publication number | Priority date | Publication date | Assignee | Title |
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KR20230133437A (ko) | 2022-03-11 | 2023-09-19 | 김현숙 | 중증 열성 혈소판 감소 증후군 바이러스 질환의 예방용 백신 조성물의 제조방법 |
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