KR102093783B1 - 트리시클릭 벤족사보롤 화합물 및 이의 용도 - Google Patents

트리시클릭 벤족사보롤 화합물 및 이의 용도 Download PDF

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KR102093783B1
KR102093783B1 KR1020167006314A KR20167006314A KR102093783B1 KR 102093783 B1 KR102093783 B1 KR 102093783B1 KR 1020167006314 A KR1020167006314 A KR 1020167006314A KR 20167006314 A KR20167006314 A KR 20167006314A KR 102093783 B1 KR102093783 B1 KR 102093783B1
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mycobacterium
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avium
clade
tuberculosis
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KR20160038901A (ko
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엠.알.케이. 앨리 (디콘)
빈센트 에스. 헤르난데즈
제이콥 제이. 플라트너
시안펭 리
데이비드 바로스-아귀레
일라리아 지오다노
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글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드
아나코르 파마슈티칼스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020167006314A 2013-08-09 2014-08-08 트리시클릭 벤족사보롤 화합물 및 이의 용도 Active KR102093783B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361864496P 2013-08-09 2013-08-09
US61/864,496 2013-08-09
US201361918976P 2013-12-20 2013-12-20
US61/918,976 2013-12-20
PCT/US2014/050370 WO2015021396A2 (en) 2013-08-09 2014-08-08 Tricyclic benzoxaborole compounds and uses thereof

Publications (2)

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KR20160038901A KR20160038901A (ko) 2016-04-07
KR102093783B1 true KR102093783B1 (ko) 2020-03-26

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US (5) US20160251380A1 (https=)
EP (2) EP4029870A1 (https=)
JP (2) JP6499175B2 (https=)
KR (1) KR102093783B1 (https=)
CN (2) CN105492388B (https=)
AP (1) AP2016009046A0 (https=)
AU (2) AU2014305792C1 (https=)
BR (1) BR112016002651B1 (https=)
CA (1) CA2919888C (https=)
CL (1) CL2016000313A1 (https=)
CR (1) CR20160064A (https=)
CY (1) CY1125030T1 (https=)
DK (1) DK3030519T3 (https=)
DO (1) DOP2016000045A (https=)
EA (1) EA032844B1 (https=)
ES (1) ES2905413T3 (https=)
HR (1) HRP20220384T1 (https=)
HU (1) HUE057365T2 (https=)
IL (1) IL243874B (https=)
LT (1) LT3030519T (https=)
MX (1) MX375556B (https=)
MY (1) MY175823A (https=)
NZ (1) NZ716350A (https=)
PE (1) PE20160752A1 (https=)
PH (1) PH12016500234B1 (https=)
PL (1) PL3030519T3 (https=)
PT (1) PT3030519T (https=)
RS (1) RS62887B1 (https=)
SA (1) SA516370551B1 (https=)
SG (2) SG11201600787PA (https=)
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SM (1) SMT202200113T1 (https=)
UA (1) UA116908C2 (https=)
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AR094961A1 (es) * 2013-03-15 2015-09-09 Lilly Co Eli 1-hidroxi-benzooxaboroles como agentes antiparasitarios
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EP3164404B1 (en) 2014-07-01 2019-04-03 Daiichi Sankyo Company, Limited Tricyclic benzoxaboroles as antibacterial agents
MA41494B1 (fr) * 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
CR20180560A (es) 2016-05-12 2019-01-25 Anacor Pharmaceuticals Inc Ésteres de oxaboral y sus usos
CN109387594B (zh) * 2017-08-08 2021-01-19 武汉武药科技有限公司 一种分离和分析贝达喹啉光学异构体的方法
PL3737685T3 (pl) * 2018-01-09 2023-10-02 Halcyon Labs Private Limited Sposób wytwarzania kryzaborolu i jego związków pośrednich
WO2021257466A1 (en) * 2020-06-15 2021-12-23 The Global Alliance For Tb Drug Development, Inc. Combination antibacterial composition and method for antibacterial therapy
CN111606850B (zh) * 2020-07-07 2023-07-25 安徽贝克生物制药有限公司 贝达喹啉及其中间体的制备方法
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
EP4384527A4 (en) * 2022-06-23 2025-09-03 Micurx Pharmaceuticals Inc PRODRUGS OF BORON COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
CA3239096A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
WO2024208907A1 (en) 2023-04-05 2024-10-10 Glaxosmithkline Intellectual Property (No. 2) Limited Synthesis of 3-(aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3h)-ol
CN117379430A (zh) * 2023-10-11 2024-01-12 深圳市第三人民医院(深圳市肝病研究所) 一种地拉韦啶的用途

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US20120115813A1 (en) 2010-09-07 2012-05-10 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US20130165411A1 (en) * 2011-12-22 2013-06-27 Micurx Pharmaceuticals, Inc. Tricyclic boron compounds for antimicrobial therapy

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US7446236B2 (en) 2002-12-02 2008-11-04 Solvias Ag Catalytic hydrogenation of carbon-heteroatom double bonds
EP2343304B1 (en) * 2005-02-16 2015-06-10 Anacor Pharmaceuticals, Inc. Biocidal boronophthalide compounds
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KR20080110984A (ko) * 2005-12-30 2008-12-22 아나코르 파마슈티칼스 인코포레이티드 보론함유 소분자
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
WO2010080558A1 (en) 2008-12-17 2010-07-15 Anacor Pharmaceuticals, Inc. Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
ES2710105T3 (es) * 2010-04-07 2019-04-23 Glaxosmithkline Llc Proceso para preparar benzoxaboroles
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
MA41494B1 (fr) * 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées

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Publication number Priority date Publication date Assignee Title
WO2008157726A1 (en) 2007-06-20 2008-12-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US20120115813A1 (en) 2010-09-07 2012-05-10 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US20130165411A1 (en) * 2011-12-22 2013-06-27 Micurx Pharmaceuticals, Inc. Tricyclic boron compounds for antimicrobial therapy

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US20180044355A1 (en) 2018-02-15
CN105492388B (zh) 2018-12-21
LT3030519T (lt) 2022-04-11
SMT202200113T1 (it) 2022-05-12
CL2016000313A1 (es) 2016-09-23
US10308668B2 (en) 2019-06-04
CN110003253A (zh) 2019-07-12
SI3030519T1 (sl) 2022-04-29
US10526352B2 (en) 2020-01-07
JP2016527321A (ja) 2016-09-08
EP4029870A1 (en) 2022-07-20
HK1219939A1 (zh) 2017-04-21
AU2014305792A1 (en) 2016-03-10
AP2016009046A0 (en) 2016-02-29
JP2019123727A (ja) 2019-07-25
PH12016500234A1 (en) 2016-05-16
CN105492388A (zh) 2016-04-13
AU2014305792B2 (en) 2017-05-04
DK3030519T3 (da) 2022-01-31
IL243874A0 (en) 2016-04-21
MY175823A (en) 2020-07-10
SG10201914073PA (en) 2020-03-30
CN110003253B (zh) 2022-03-18
AU2014305792C1 (en) 2018-07-05
HRP20220384T1 (hr) 2022-07-22
BR112016002651A2 (pt) 2017-08-01
SG11201600787PA (en) 2016-03-30
CY1125030T1 (el) 2023-03-24
EA032844B1 (ru) 2019-07-31
US20190241586A1 (en) 2019-08-08
WO2015021396A3 (en) 2015-10-29
NZ716350A (en) 2022-12-23
US20210053999A1 (en) 2021-02-25
MX2016001732A (es) 2016-05-18
CA2919888C (en) 2022-10-18
ZA201600792B (en) 2022-05-25
CA2919888A1 (en) 2015-02-12
CR20160064A (es) 2016-06-01
PL3030519T3 (pl) 2022-05-23
WO2015021396A9 (en) 2016-02-11
IL243874B (en) 2018-11-29
JP6764970B2 (ja) 2020-10-07
ES2905413T3 (es) 2022-04-08
PH12016500234B1 (en) 2019-01-30
RS62887B1 (sr) 2022-03-31
BR112016002651B1 (pt) 2022-11-29
HUE057365T2 (hu) 2022-05-28
DOP2016000045A (es) 2016-04-29
MX375556B (es) 2025-03-06
US20200095266A1 (en) 2020-03-26
AU2017210567B2 (en) 2019-08-01
EP3030519A4 (en) 2017-03-08
WO2015021396A2 (en) 2015-02-12
US10858376B2 (en) 2020-12-08
SA516370551B1 (ar) 2017-10-31
PT3030519T (pt) 2022-01-27
EP3030519A2 (en) 2016-06-15
AU2017210567A1 (en) 2017-08-24
UA116908C2 (uk) 2018-05-25
US20160251380A1 (en) 2016-09-01
EA201690135A1 (ru) 2016-07-29
JP6499175B2 (ja) 2019-04-10
EP3030519B1 (en) 2022-01-05
PE20160752A1 (es) 2016-08-17
KR20160038901A (ko) 2016-04-07

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