BR112016002651B1 - Composto, composição farmacêutica, combinação, e, uso de um composto - Google Patents

Composto, composição farmacêutica, combinação, e, uso de um composto Download PDF

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Publication number
BR112016002651B1
BR112016002651B1 BR112016002651-9A BR112016002651A BR112016002651B1 BR 112016002651 B1 BR112016002651 B1 BR 112016002651B1 BR 112016002651 A BR112016002651 A BR 112016002651A BR 112016002651 B1 BR112016002651 B1 BR 112016002651B1
Authority
BR
Brazil
Prior art keywords
mycobacterium
compound
trioxa
tuberculosis
borabenzo
Prior art date
Application number
BR112016002651-9A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112016002651A2 (pt
Inventor
M.R.K. (Dickon) Alley
Vincent S. Hernandez
Jacob J. Plattner
Xianfeng Li
David Barros-Aguirre
Ilaria Giordano
Original Assignee
Anacor Pharmaceuticals, Inc.
Glaxosmithkline Intellectual Property (No. 2) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anacor Pharmaceuticals, Inc., Glaxosmithkline Intellectual Property (No. 2) Limited filed Critical Anacor Pharmaceuticals, Inc.
Publication of BR112016002651A2 publication Critical patent/BR112016002651A2/pt
Publication of BR112016002651B1 publication Critical patent/BR112016002651B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BR112016002651-9A 2013-08-09 2014-08-08 Composto, composição farmacêutica, combinação, e, uso de um composto BR112016002651B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361864496P 2013-08-09 2013-08-09
US61/864,496 2013-08-09
US201361918976P 2013-12-20 2013-12-20
US61/918,976 2013-12-20
PCT/US2014/050370 WO2015021396A2 (en) 2013-08-09 2014-08-08 Tricyclic benzoxaborole compounds and uses thereof

Publications (2)

Publication Number Publication Date
BR112016002651A2 BR112016002651A2 (pt) 2017-08-01
BR112016002651B1 true BR112016002651B1 (pt) 2022-11-29

Family

ID=52462052

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002651-9A BR112016002651B1 (pt) 2013-08-09 2014-08-08 Composto, composição farmacêutica, combinação, e, uso de um composto

Country Status (35)

Country Link
US (5) US20160251380A1 (https=)
EP (2) EP4029870A1 (https=)
JP (2) JP6499175B2 (https=)
KR (1) KR102093783B1 (https=)
CN (2) CN105492388B (https=)
AP (1) AP2016009046A0 (https=)
AU (2) AU2014305792C1 (https=)
BR (1) BR112016002651B1 (https=)
CA (1) CA2919888C (https=)
CL (1) CL2016000313A1 (https=)
CR (1) CR20160064A (https=)
CY (1) CY1125030T1 (https=)
DK (1) DK3030519T3 (https=)
DO (1) DOP2016000045A (https=)
EA (1) EA032844B1 (https=)
ES (1) ES2905413T3 (https=)
HR (1) HRP20220384T1 (https=)
HU (1) HUE057365T2 (https=)
IL (1) IL243874B (https=)
LT (1) LT3030519T (https=)
MX (1) MX375556B (https=)
MY (1) MY175823A (https=)
NZ (1) NZ716350A (https=)
PE (1) PE20160752A1 (https=)
PH (1) PH12016500234B1 (https=)
PL (1) PL3030519T3 (https=)
PT (1) PT3030519T (https=)
RS (1) RS62887B1 (https=)
SA (1) SA516370551B1 (https=)
SG (2) SG11201600787PA (https=)
SI (1) SI3030519T1 (https=)
SM (1) SMT202200113T1 (https=)
UA (1) UA116908C2 (https=)
WO (1) WO2015021396A2 (https=)
ZA (1) ZA201600792B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR094961A1 (es) * 2013-03-15 2015-09-09 Lilly Co Eli 1-hidroxi-benzooxaboroles como agentes antiparasitarios
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EP3164404B1 (en) 2014-07-01 2019-04-03 Daiichi Sankyo Company, Limited Tricyclic benzoxaboroles as antibacterial agents
MA41494B1 (fr) * 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
CR20180560A (es) 2016-05-12 2019-01-25 Anacor Pharmaceuticals Inc Ésteres de oxaboral y sus usos
CN109387594B (zh) * 2017-08-08 2021-01-19 武汉武药科技有限公司 一种分离和分析贝达喹啉光学异构体的方法
PL3737685T3 (pl) * 2018-01-09 2023-10-02 Halcyon Labs Private Limited Sposób wytwarzania kryzaborolu i jego związków pośrednich
WO2021257466A1 (en) * 2020-06-15 2021-12-23 The Global Alliance For Tb Drug Development, Inc. Combination antibacterial composition and method for antibacterial therapy
CN111606850B (zh) * 2020-07-07 2023-07-25 安徽贝克生物制药有限公司 贝达喹啉及其中间体的制备方法
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
EP4384527A4 (en) * 2022-06-23 2025-09-03 Micurx Pharmaceuticals Inc PRODRUGS OF BORON COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
CA3239096A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
WO2024208907A1 (en) 2023-04-05 2024-10-10 Glaxosmithkline Intellectual Property (No. 2) Limited Synthesis of 3-(aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3h)-ol
CN117379430A (zh) * 2023-10-11 2024-01-12 深圳市第三人民医院(深圳市肝病研究所) 一种地拉韦啶的用途

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EP0947498B1 (en) 1996-12-02 2004-09-15 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same
US7446236B2 (en) 2002-12-02 2008-11-04 Solvias Ag Catalytic hydrogenation of carbon-heteroatom double bonds
EP2343304B1 (en) * 2005-02-16 2015-06-10 Anacor Pharmaceuticals, Inc. Biocidal boronophthalide compounds
EP1856113B1 (en) 2005-03-08 2016-01-06 Agency for Science, Technology and Research Chiral bisoxazoline catalysts
CN101505603A (zh) * 2005-12-30 2009-08-12 安纳考尔医药公司 含硼的小分子
KR20080110984A (ko) * 2005-12-30 2008-12-22 아나코르 파마슈티칼스 인코포레이티드 보론함유 소분자
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
WO2010080558A1 (en) 2008-12-17 2010-07-15 Anacor Pharmaceuticals, Inc. Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
ES2710105T3 (es) * 2010-04-07 2019-04-23 Glaxosmithkline Llc Proceso para preparar benzoxaboroles
SI3251678T1 (sl) * 2010-09-07 2022-01-31 Anacor Pharmaceuticals, Inc. Derivati benzoksaborola za zdravljenje bakterijskih okužb
JP6031122B2 (ja) * 2011-12-22 2016-11-24 ミクウルク ファーマシューティカルズ，インコーポレイテッド 抗微生物療法のための三環式ホウ素化合物
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
MA41494B1 (fr) * 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées

Also Published As

Publication number Publication date
US20180044355A1 (en) 2018-02-15
CN105492388B (zh) 2018-12-21
LT3030519T (lt) 2022-04-11
SMT202200113T1 (it) 2022-05-12
CL2016000313A1 (es) 2016-09-23
US10308668B2 (en) 2019-06-04
CN110003253A (zh) 2019-07-12
SI3030519T1 (sl) 2022-04-29
US10526352B2 (en) 2020-01-07
JP2016527321A (ja) 2016-09-08
EP4029870A1 (en) 2022-07-20
HK1219939A1 (zh) 2017-04-21
AU2014305792A1 (en) 2016-03-10
AP2016009046A0 (en) 2016-02-29
JP2019123727A (ja) 2019-07-25
PH12016500234A1 (en) 2016-05-16
CN105492388A (zh) 2016-04-13
AU2014305792B2 (en) 2017-05-04
DK3030519T3 (da) 2022-01-31
IL243874A0 (en) 2016-04-21
MY175823A (en) 2020-07-10
SG10201914073PA (en) 2020-03-30
CN110003253B (zh) 2022-03-18
AU2014305792C1 (en) 2018-07-05
KR102093783B1 (ko) 2020-03-26
HRP20220384T1 (hr) 2022-07-22
BR112016002651A2 (pt) 2017-08-01
SG11201600787PA (en) 2016-03-30
CY1125030T1 (el) 2023-03-24
EA032844B1 (ru) 2019-07-31
US20190241586A1 (en) 2019-08-08
WO2015021396A3 (en) 2015-10-29
NZ716350A (en) 2022-12-23
US20210053999A1 (en) 2021-02-25
MX2016001732A (es) 2016-05-18
CA2919888C (en) 2022-10-18
ZA201600792B (en) 2022-05-25
CA2919888A1 (en) 2015-02-12
CR20160064A (es) 2016-06-01
PL3030519T3 (pl) 2022-05-23
WO2015021396A9 (en) 2016-02-11
IL243874B (en) 2018-11-29
JP6764970B2 (ja) 2020-10-07
ES2905413T3 (es) 2022-04-08
PH12016500234B1 (en) 2019-01-30
RS62887B1 (sr) 2022-03-31
HUE057365T2 (hu) 2022-05-28
DOP2016000045A (es) 2016-04-29
MX375556B (es) 2025-03-06
US20200095266A1 (en) 2020-03-26
AU2017210567B2 (en) 2019-08-01
EP3030519A4 (en) 2017-03-08
WO2015021396A2 (en) 2015-02-12
US10858376B2 (en) 2020-12-08
SA516370551B1 (ar) 2017-10-31
PT3030519T (pt) 2022-01-27
EP3030519A2 (en) 2016-06-15
AU2017210567A1 (en) 2017-08-24
UA116908C2 (uk) 2018-05-25
US20160251380A1 (en) 2016-09-01
EA201690135A1 (ru) 2016-07-29
JP6499175B2 (ja) 2019-04-10
EP3030519B1 (en) 2022-01-05
PE20160752A1 (es) 2016-08-17
KR20160038901A (ko) 2016-04-07

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/08/2014, OBSERVADAS AS CONDICOES LEGAIS

B25D Requested change of name of applicant approved

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) ; ANACOR PHARMACEUTICALS, LLC (US)

B25G Requested change of headquarter approved

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) ; ANACOR PHARMACEUTICALS, LLC (US)

B25G Requested change of headquarter approved

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) ; ANACOR PHARMACEUTICALS, LLC (US)

B25G Requested change of headquarter approved

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) ; ANACOR PHARMACEUTICALS, LLC (US)