KR102074828B1 - Radionuclide extraction apparatus - Google Patents

Abstract

Provided is a radionuclide separator. According to an embodiment of the present invention, the radionuclide separator comprises: a holder unit with at least one column to extract a certain radionuclide from a sample; a manifold block disposed on the holder unit to be able to move up and down through driving of a first driving means, and having an injection hole formed therethrough at a position corresponding to the column; a supply unit sucking a predetermined amount of a reagent or cleaning liquid from at least one reagent container or cleaning liquid container and supplying the same into the column through the injection hole; a support plate having at least one extract recollecting container disposed on an upper surface to collect a discharged liquid from the column, and moved in a horizontal direction linearly and repeatedly by driving of a second driving means to place the extract recollecting container under the column or separate the same from under the column; a waste liquid collecting unit disposed under the column to collect a waste liquid discharged from the column; and a control unit for controlling overall driving.

Description

Radionuclide Separation Device {RADIONUCLIDE EXTRACTION APPARATUS}

The present invention relates to a radionuclide separation device, and more particularly, to an automated column extraction device capable of separating several radionuclides sequentially from one sample.

Since beta radionuclides in radioactive waste are difficult to accurately analyze due to their broad spectrum and similar interfering radionuclides, chemical separation processes must be preceded to selectively measure specific beta radionuclides.

Gravity extraction using resin is traditionally used as a chemical separation process for beta radionuclides. However, since the fluid injected into the column is purified and eluted by gravity, it takes a lot of test time, and the whole work is done by hand. Therefore, there is a problem that involves a lot of labor.

To solve this problem, an automatic separation system for separating two or more radionuclides mixed in a single sample was developed. However, since all pipelines are connected, cross contamination may occur, and they are included in long pipelines and routes to reduce contamination. Since there is a need to clean a plurality of valves, the amount of secondary waste due to the excessive use of the cleaning liquid is increased.

Accordingly, there is a need for a column extraction device in which radioactive samples do not come into contact with pipelines or components other than resin columns and recovery containers that are typically used for single use.

In another example of an automated column extraction device, a column is arranged in a circumferential direction, a sample or reagent can be injected through a rotational drive, and nucleic acid extraction includes a pressurizing unit for pressurizing the column to control elution characteristics. The device has been developed.

However, such a nucleic acid extracting device has a problem in that it is impossible to determine the purification and elution states of individual columns, although it is possible to inject a plurality of samples or reagents by a simple rotational drive. In addition, since one eluent recovery container tray is installed by a manual replacement method, it cannot be applied to an automated multi-stage separation process.

The present invention has been made in view of the above, it is possible to rapidly proceed with the radionuclide separation process, it is possible to accurately control the radionuclide separation process that proceeds sequentially, and to automatically control a plurality of trays placed recovery container Its purpose is to provide an automated radionuclide separation device that can be supplied and loaded.

In order to achieve the above object, the present invention provides a holder unit for mounting at least one column for extracting a predetermined radionuclide from a sample; A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column; A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole; At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column; A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column; And a control unit for controlling the overall driving.

According to the present invention, it is possible to reduce the test time and manpower by automating the radionuclide separation process, and to plan and execute the sequential separation process through the monitoring using the sensor to reduce the manual error by eliminating the manual intervention of the operator have.

In addition, the present invention does not have the possibility of cross-contamination, and the flow rate and pressure of the compressor body is controlled and supplied to the inside of the column, so that rapid analysis is possible and a sequential radionuclide separation process may be continuously implemented.

1 is a view showing a radionuclide separation device according to an embodiment of the present invention.
Figure 2 is a cross-sectional view showing the detailed configuration of the column that can be used in the radionuclide separation device according to an embodiment of the present invention.
3 is a view showing an extract of the holder portion, the manifold block and the support plate in FIG.
FIG. 4 is a diagram illustrating a connection relationship between a supply unit and a manifold block in FIG. 1.
5 is a view showing a configuration embedded in the upper body in FIG.
FIG. 6 is a view schematically illustrating a method of supplying a reagent or a cleaning solution supplied to a filling hole side through a supply unit in a radionuclide separation device according to an embodiment of the present invention.
FIG. 7 is a view schematically illustrating a method of supplying a reagent or a washing solution when a plurality of suction parts and distribution parts are provided in the radionuclide separation device according to an embodiment of the present invention.
8 is a view schematically showing the reciprocating movement of the support plate using the loader in FIG.
FIG. 9 is a view schematically showing a driving method of a stacker in FIG. 1.
10 is a view showing the initial state of the radionuclide separation device according to an embodiment of the present invention.
11 is a view showing a process in which the extraction process by moving the support plate to the extraction space in the stacker in the radionuclide separation device according to an embodiment of the present invention.
12 is a view showing a process in which the recovery container for extraction in the radionuclide separation device according to an embodiment of the present invention moves to the stacker side and the waste liquid is collected to the waste liquid recovery container side.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. In the drawings, parts irrelevant to the description are omitted in order to clearly describe the present invention, and like reference numerals designate like elements throughout the specification.

Radionuclide separation device 100 according to an embodiment of the present invention, as shown in Figure 1 holder 120, manifold block 130, supply unit 140, support plate 150, waste liquid collection unit 170 and the controller 180.

The holder 120 may be equipped with at least one column 10 for extracting a desired radionuclide from a sample. To this end, the holder 120 may be formed through the at least one mounting hole 121 so that the upper portion of the column 10 can be mounted.

For example, the holder part 120 may be a plate-shaped plate fixed to the main body parts 111 and 112, the mounting hole 121 may be formed through the height direction of the plate-shaped plate.

In the present invention, the main body (111, 112) is the upper main body 111 and the lower main body 112 is formed of a frame structure on the lower side of the upper main body 111, the supply unit 140 and the control unit 180 is installed It may include, the holder 120 may be fixed to the lower body 112 side.

For example, the lower body 112 may include a bottom plate 113 having a predetermined area, a plurality of first pillar frames 114a extending in a height direction from the bottom plate 113, and having a predetermined length; It may include a second pillar frame 114b, the holder portion 120 may be fixed to the upper side of the second pillar frame (114b). Here, the plurality of first pillar frame 114a may support the upper body 111 by having an upper end directly connected to the upper body 111.

In this case, the lower body 112 has a first space (S1) and the holder is disposed on the stacker 160 to be described later via the plurality of first pillar frame (114a) and the second pillar frame (114b) The lower side of the column 10 mounted on the unit 120 may be divided into a second space (S2), the second space (S2) is the lower portion of the column 10 and the extract liquid recovery container 40 ) May be divided into an extraction space (S21) that can be disposed and a collection space (S22) where the waste liquid collecting unit 170 may be disposed.

Meanwhile, the mounting holes 121 may be provided in plural as shown in FIG. 3, and when the columns 10 are provided in plural numbers, each column 10 is one-to-one in the mounting holes 121. Can be fixed.

In the present invention, the column 10 may be a hollow member having an inner space of which the upper part is opened as shown in FIG. 2, and an outlet (so that the liquid passing through the inner space may be discharged to the lower side). 16) can be formed, and the upper side can have a relatively wider width than the middle of the length. Accordingly, the column 10 may be mounted to the mounting hole 121 through the upper side.

In addition, a predetermined amount of resin 12 may be filled between the pair of filter members 14 in the inner space of the column 10, and a sample containing radionuclides to be extracted on the upper side of the resin 12. Can be filled in a certain amount.

Accordingly, when the reagent is supplied to the upper side of the column 10, the sample may be discharged through the outlet 16 through the filter member 14 and the resin together with the reagent.

Here, the radionuclides contained in the sample may be separated from the sample by being adsorbed to the resin or adsorbed to the resin in the course of passing through the resin, depending on the type of the reagent. Can be. Since the radionuclide separation method is well-known contents, detailed description thereof will be omitted.

At this time, the mounting hole 121 may be a sealing member 122 is disposed along the edge. The sealing member 122 is the manifold block 130 is lowered through the first drive means when the protrusion 132 of the manifold block 130 covers the open top of the column 10, the It may be in contact with the protrusion 132.

Accordingly, when the reagent, the cleaning liquid, and the compressor body are supplied to the open upper side of the column 10 through the inside of the protrusion 132, the reagent, the cleaning liquid, the compressor body, and the like may be prevented from leaking to the outside. have.

As shown in FIG. 3, the manifold block 130 may be disposed on an upper side of the holder part 120, and an injection hole may be disposed at a position corresponding to the column 10 mounted on the holder part 120. 131 may be formed through. Here, when the injection hole 131 is formed with a plurality of mounting holes 121 to mount the plurality of columns 10 to the holder 120 as shown in Figure 4, the plurality of mounting The ball 121 may be provided in plural so as to correspond one-to-one, and the plurality of injection holes 131 may be formed to be positioned directly above the mounting hole 121.

Accordingly, the reagent or the cleaning liquid supplied from the supply unit 140 may be smoothly injected into the column 10 through the injection hole 131.

At this time, the manifold block 130 may include a hollow protrusion 132 protruding a predetermined length to surround the injection hole 131 on the lower surface, the manifold block 130 is a first It may be raised or lowered from the upper portion of the holder portion 120 through the driving means.

Accordingly, the manifold block 130 is lowered through the first driving means, and the reagent or the cleaning liquid is inside the column 10 while the protrusion 132 covers the top of the column 10. Can be injected into. In this case, the sealing member 122 provided at the edge of the mounting hole 121 may maintain a state in close contact with the protrusion 132.

Through this, the reagent or cleaning liquid supplied from the supply unit 140 is the injection hole 131 is connected to the upper portion of the column 10, the reagent or cleaning liquid leaks to the outside through the sealing member 122 By blocking it, the reagent or cleaning solution supplied from the supply unit 140 may be smoothly injected into the column 10 through the injection hole 131.

To this end, the manifold block 130 may be coupled to the second pole frame 114b and the guide rod 115 side connecting the upper body 111 to be slidably movable in the up and down directions, One side of the first driving means may be connected to the manifold block 130. For example, the first driving means may be a cylinder 134, the first driving means may be fixed to the support plate 116 of the upper body 111, the manifold block 130 is the support plate It may be connected to the cylinder rod 134a passing through 116.

Accordingly, the manifold block 130 may be raised or lowered with respect to the support plate 116 of the upper body 111, and when the manifold block 130 is lowered, the protruding portion 132 is the holder. The upper portion of the column 10 mounted on the portion 120 may be covered.

On the other hand, the radionuclide separation device 100 according to an embodiment of the present invention to the inside of the column 10 in the process of supplying the reagent or washing liquid into the column 10 through the injection hole 131 All the compressor bodies having a predetermined pressure can be supplied.

Accordingly, the passage speed of the sample and the reagent passing through the resin in the column 10 and discharged to the outlet 16 of the column 10 may be increased through the compressor body. This may increase the process speed for separating the desired radionuclide from the sample.

To this end, the manifold block 130 may include at least one gas movement path 133 formed to communicate with the injection hole 131, as shown in FIG.

For example, the gas movement path 133 may be formed in the manifold block 130 in a direction perpendicular to the injection hole 131, the injection hole 131 formed in the manifold block 130 is When provided in plural, the gas movement path 133 may be formed in one-to-one communication with the plurality of injection holes 131.

The gas flow path 133 may be directly connected to the compressor body supply means (not shown) via the connecting pipe 118, but the flow controller 117 and the connection pipe 118 connected to the compressor body supply means may be connected. It can be connected by media.

Through this, the compressor body supplied to the gas movement path 133 may be supplied after being adjusted to an appropriate flow rate through the flow controller 117. Here, the compressor body supplied to the flow controller 117 may be a pressure is controlled through a separate regulator (not shown).

Accordingly, the compressor body supplied through the flow controller 117 may be supplied into the column 10 in a state in which pressure and flow rate are adjusted through the gas movement path 133. For this reason, the radionuclide separation device 100 according to an embodiment of the present invention has a suitable pressure and flow rate of the compressor body supplied into the column 10 according to the type of the sample injected into the column 10. It can be supplied so that the reaction time can be shortened while ensuring sufficient reaction time can increase the recovery rate of the desired radionuclide.

For example, the flow controller 117 may be provided in the upper body 111, when the plurality of gas movement path 133 formed in the manifold block 130 is provided with the plurality of gas movement path ( 133 and the connection pipe 118 may be connected one-to-one.

Here, the flow rate of the compressor body supplied to the gas movement path 133 through the flow controller 117 may be adjusted through the control of the controller 180, the controller 180 of the column 10 The supply flow rate of the flow controller 117 may be adjusted based on information measured by at least one sensor 123 or 124 monitoring the extraction state of the sample and the reagent passing through the inside.

That is, the radionuclide separation device 100 according to an embodiment of the present invention may further include at least one sensor 123 and 124 for monitoring the extraction state of the sample and the reagent passing through the interior of the column 10. .

For example, the sensors 123 and 124 may measure the extraction state of the liquid passing through the inside of the column 10 to determine the injection of the reagent, the supply of the compressor body, the completion of the extraction process, and the like. By using the optical property change according to the presence or absence of the liquid present in the inside or by using the reflection characteristics of the sound waves it can be determined whether the injection of the reagent, the supply of the compressor body and the completion of the extraction process.

The sensors 123 and 124 may be installed at the outlet of the column 10 or in the middle of the length of the column 10, and detect the droplet falling to the outlet 16 of the column to determine the progress of the extraction process. The level of the liquid in the column 10 may be measured to determine whether the extraction process is complete.

In detail, the sensors 123 and 124 are disposed in the middle of the length of the column 10 as shown in FIG. 3 to measure the height of a reagent or a sample passing through the inside of the column 10 ( 123 and at least one of a second sensor 124 disposed on the outlet 16 side of the column 10 to detect a state of the discharge liquid falling from the outlet 16 of the column 10. can do.

Here, the first sensor 123 may be a capacitive sensor for measuring the liquid level in the column 10, the second sensor 124 may be an optical fiber sensor for measuring the drop of the eluate. have. In addition, the first sensor 123 is disposed at a position corresponding to the filter member 14 disposed on the upper side of the resin 12 of the pair of filter members 14 disposed inside the column 10. Can be.

However, the type of the first sensor 123 and the second sensor 124 is not limited thereto, and if the state of the liquid discharged to the outside through the outlet 16 of the column in the column may be measured, a known Various sensors can all be used.

The sensors 123 and 124 may be provided to match one-to-one with the column 10 mounted on the holder part 120.

The supply unit 140 may supply a reagent or a washing solution into the column 10.

Through this, the radionuclide separation apparatus 100 according to an embodiment of the present invention separates the desired radionuclide from the sample stored in the column 10 by using the reagent supplied from the supply unit 140 or the The inside of the column 10 may be washed with the cleaning liquid supplied from the supply unit 140 and then changed into a reuse state.

To this end, as shown in FIGS. 1 and 4, the supply unit 140 may use a reagent container 20 in which a certain amount of the reagent is stored, and a cleaning liquid container 30 and a first tube 61 in which a predetermined amount of the cleaning liquid is stored. They may be connected to each other, and may be connected to each injection hole 131 formed in the manifold block 130 through the other tube (62, 63).

Here, the reagent container 20 may be provided with a plurality of different kinds of reagents stored therein, and may be provided at one side of the upper body 111 together with the cleaning liquid container 30.

For example, a pedestal 191 in which the reagent container 20 and the cleaning liquid container 30 are placed may be disposed on an upper surface of the upper body 111, and the reagent container 20 and the cleaning liquid container 30 may be disposed. May be connected to the supply unit 140 via the first tube 61 in a state of being placed on the pedestal 191.

In addition, the pedestal 191 may be provided with a weight sensor (not shown) for measuring the weight of the reagent container 20 and the cleaning liquid container 30, the information measured by the weight sensor is the control unit ( 180 may be provided to the side, and the weight information about the reagent container 20 and the cleaning solution container 30 provided to the control unit 180 side may be displayed through separate notification means. For example, the notification means may be a display 192 provided on the upper body 111.

 Accordingly, the operator can check in real time the amount of the reagent container 20 and the cleaning liquid container 30 provided through the display 192, the reagent or cleaning liquid filled in the reagent container 20 and the cleaning liquid container (30) When the amount is insufficient, the reagent or cleaning solution may be replenished in the container or replaced with an unused reagent container 20 or cleaning solution container 30.

However, the notification means is not limited to the display 192, and the notification means may be provided in a manner of outputting an alarm sound.

In this case, the supply unit 140 may selectively suck a predetermined amount of the reagent or cleaning solution required for the process from the reagent container 20 or the cleaning solution container 30, and then supply it to the column 10 mounted on the holder part 120. Can be.

To this end, the supply unit 140 is at least one connected in a one-to-one manner through the reagent vessel 20 and the washing liquid container 30 and a plurality of first tubes 61, as shown in Figures 4 to 6 It may include a suction unit 141, the suction unit 141 is raised and lowered by the driving of the first valve body 142b and the second motor 145 to rotate through the drive of the first motor 144. It may include a piston member (143c).

As a non-limiting example, the suction part 141 is fixed to one side of the upper body 111 and is mounted inside the first housing 142a and the first housing 142a and the plurality of flow paths are formed. The first valve body 142b is rotated by the driving of the first motor 144 and is connected to any one of the plurality of flow paths of the first housing 142a and the storage space therein. A cylinder member 143b having an enclosure shape having a 143a and a piston member 143c which is raised and lowered in the cylinder member 143b may be included.

Here, the first housing 142a may have a plurality of flow paths connected to the reagent container 20 and the cleaning liquid container 30 one-to-one, respectively, via the first tube 61, and the piston member 143c. One end may be connected to the moving body 143d, which is lifted and lowered by driving the second motor 145.

Through this, any one of the plurality of flow paths formed in the first valve body 142b communicates with any one of the reagent container 20 or the cleaning liquid container 30 through the first tube 61 and the first tube 61. The piston member 143c descends by driving the second motor 145 while any one of a plurality of flow paths formed in the valve body 142b communicates with the storage space 143a of the cylinder member 143b. In this case, a certain amount of the reagent or cleaning liquid may be sucked from the reagent container 20 or the cleaning liquid container 30 to the storage space 143a of the cylinder member 143b (see FIG. 6A).

Thereafter, the first valve body 142b is rotated so that any one of a plurality of flow paths formed in the first valve body 142b is in communication with the storage space 143a of the cylinder member 143b. When any one of the plurality of flow paths formed in the valve body 142b is changed to communicate with the flow path connected to the injection hole 131 and the piston member 143c is elevated by the drive of the second motor 145, A predetermined amount of the reagent or the washing solution stored in the storage space 143a may be supplied into the column 10 through the injection hole 131 (see FIG. 6B).

Here, the driving of the first motor 144 and the second motor 145 may be controlled through the controller 180.

For this reason, the radionuclide separation device 100 according to an embodiment of the present invention controls the rising and falling distance of the piston member 143c through the control unit 180 through the injection hole 131 through the column ( The amount of reagent or washing solution injected into 10) can be quantitatively controlled.

In addition, the radionuclide separation device 100 according to an exemplary embodiment of the present invention rotates the first valve body 142b through the control unit 180 to form a reagent or a reagent from the reagent container 20 or the cleaning liquid container 30. By selectively sucking the cleaning liquid and supplying the inside of the column 10, the radionuclide separation process may be performed, or the washing operation inside the column may be performed through the supply of the cleaning liquid.

For this reason, the radionuclide separation device 100 according to an embodiment of the present invention supplies a reagent to the inner side of the column 10 to perform a separation operation of the radionuclide, and then washes the washing liquid to the inner side of the column 10. Since the inside of the column may be supplied and washed, the column 10 mounted on the holder 120 may be repeatedly reused without replacing the column 10.

At this time, the radionuclide separation device 100 according to an embodiment of the present invention is formed with a plurality of mounting holes 121 in the holder portion 120 and a plurality of columns 10 in the plurality of mounting holes 121. In each case, the supply unit 140 may include a plurality of reagents or cleaning liquids, which are sucked from the reagent container 20 or the cleaning liquid container 30 through the suction unit 141, mounted on the holder part 120. Quantitative distribution may be made to the two column 10 sides.

For example, the supply unit 140 may further include a distribution unit 146 connected through the suction unit 141 and the second tube 62 as shown in FIGS. 4 and 6. The distribution unit 146 may be connected to the plurality of injection holes 131 formed in the manifold block 130 through the plurality of third tubes 63 one-to-one, respectively. In this case, the third tube 63 may have an appropriate length so that interference does not occur when the manifold block 130 moves up and down.

As a non-limiting example, the distribution unit 146 is mounted to the second housing 147a fixed to one side of the upper body 111 and the second housing 147a, and the third motor 148. It may include a second valve body 147b is rotated by the driving of the plurality of flow paths are formed, the second valve body 147b and the suction unit 141 via the second tube (62). Can be connected.

Through this, if any one of the plurality of flow paths formed in the second valve body 147b is selectively communicated with any one of the plurality of injection holes 131 via the third tube 63, the cylinder member Some of the reagents or cleaning liquids of the reagents or cleaning liquids stored in the storage space 143a of 143b may be selectively supplied to one of the injection holes 131 of the plurality of injection holes 131 (FIG. 6B). ) Reference).

Thereafter, the second valve body 147b is rotated so that any one of a plurality of flow paths formed in the second valve body 147b mediates the other one of the plurality of injection holes 131 and the third tube 63. When selectively communicated with each other, the reagent or cleaning liquid of another part of the reagent or cleaning liquid remaining in the storage space 143a of the cylinder member 143b may be selectively supplied to the other injection hole 131 (FIG. 6). (c)).

When the above process is repeated, the reagent or washing liquid first introduced into the storage space 143a of the cylinder member 143b may be distributed to a plurality of columns 10 by a predetermined amount.

For this reason, the radionuclide separation device 100 according to an embodiment of the present invention may uniformly distribute a certain amount of reagent or washing liquid to the plurality of columns 10 by driving the second valve body 147b. As a result, a large number of radionuclides can be separated simultaneously using a plurality of columns 10 through a single process.

On the other hand, the radionuclide separation device 100 according to an embodiment of the present invention may be provided with a plurality of suction unit 141 and the distribution unit 146 constituting the supply unit 140, respectively.

In one example, the radionuclide separation device 100 according to an embodiment of the present invention, as shown in FIG. 7, the supply unit 140 may include two suction units 141 and two distribution units 146. Can be.

In this case, the two suction portions 141 may be connected one-to-one through the respective reagent vessels 20 or the washing liquid vessel 30 and the first tube 61, respectively, two suction portions 141 and two Distribution units 146 may be connected one-to-one via the second tube 62. In addition, any one of the two distribution units 146 may be connected to some of the plurality of injection holes 131 formed in the manifold block 130 and the third tube 63, the other injection The ball and the third tube 63 may be connected via a medium.

Here, the operation method and the detailed configuration of the two suction unit 141 and the two distribution unit 146 is the same as the above description will be omitted the detailed description.

In this case, the two suction parts 141 may simultaneously suck the reagent or the cleaning solution from the reagent container 20 or the cleaning solution container 30, and then supply the two suction parts 141 to the two distribution parts 146. The two distribution units 146 may simultaneously supply reagents or cleaning solutions to two injection holes 131 of the plurality of injection holes 131 formed in the manifold block 130. In this way, the two dispensing units 146 transfer the reagents or cleaning liquids supplied from the two suction units 141 to two column 10 sides of the plurality of columns 10 mounted on the holder unit 120. At the same time, the process time can be shortened.

In the drawings, the suction unit 141 and the distribution unit 146 are illustrated as two, but are not limited thereto, and may be appropriately changed according to the total number of columns 10 that may be mounted on the holder unit 120. Can be.

In addition, in the radionuclide separation device 100 according to an embodiment of the present invention, the supply part 140 may include a plurality of suction parts 141. In this case, each suction unit 141 is connected to the reagent container 20 and / or the cleaning liquid container 30, respectively, and at least one of the plurality of injection holes 131 formed in the manifold block 130 It may be directly connected to the injection hole 131. Through this, the supply unit 140 may also be able to simultaneously inject a reagent or cleaning solution to the plurality of column 10 side through the plurality of suction unit 141. In this case, the distribution unit 146 may be omitted.

The support plate 150 may be disposed in the extraction space (S21) formed on the lower side of the holder portion 120 as shown in FIG. At least one extraction liquid recovery container 40 may be disposed on the upper surface of the support plate 150 to collect the discharge liquid falling from the outlet 16 of the column 10.

Here, the extract liquid recovery container 40 may be an enclosure having an upper portion open to easily collect the discharge liquid falling from the outlet 16 of the column 10, the plurality of holders 120 When the two columns 10 are mounted, a plurality of columns 10 may be provided on the lower side corresponding to the plurality of columns 10 so as to separately collect the discharge liquids falling from each column 10. .

In one example, the support plate 150 is provided as a plate-like member having a predetermined area so that the edge side is supported by a partition frame 114c interconnecting the middle lengths of the plurality of second pillar frames 114b. The collection space (S22) may be formed on the lower side of the partition frame (114c) is provided with the waste collection unit 170, the collection space (S22) may be in the form of an open upper side.

In this case, the partition frame 114c may be formed of an empty frame structure, and the edge of the support plate 150 may be supported through the partition frame 114c as shown in FIG. 11. have.

As a result, as shown in FIG. 12, when the support plate 150 is separated from the extraction space S21, the waste liquid falling from the outlet 16 of the column 10 is provided in the collection space S22. It can be introduced directly to the waste liquid collection unit 170 side.

Here, the waste liquid collection unit 170 is disposed on an upper side of the waste liquid recovery container 50 and the waste liquid recovery container 50 for storing the waste liquid falling from the outlet 16 of the column 10. It may include a guide member 172 for guiding the waste liquid falling from the outlet 16 of the (10) to the inlet of the waste liquid recovery container (50).

For example, the guide member 172 may be a funnel member whose upper and lower portions are open and whose cross-sectional area decreases from the upper part to the lower part, and the funnel member has a discharge port 173 for discharging the waste liquid to the outside at the center thereof. Can be.

Accordingly, although the waste liquid is discharged from each of the plurality of columns 10 mounted on the holder part 120, the waste liquid discharged from the plurality of columns 10 drops to the guide member 172 and then the discharge port 173. ) Can flow down to the central portion formed, the waste liquid flowing down to the discharge port 173 side can be smoothly dropped to the waste liquid recovery container 50 side through the discharge port (173).

Here, the bottom plate 113 of the lower body 112 constituting the bottom surface of the collection space (S22) may be provided with a weight sensor (not shown) for measuring the weight of the waste liquid recovery container (50) The information measured by the weight sensor may be provided to the control unit 180, and the weight information about the waste liquid collection container 50 provided to the control unit 180 may be displayed through a separate notification means. For example, the notification means may be the above-described display 192 provided to the upper body 111.

 Accordingly, the operator can check the amount of the waste liquid recovery container 50 provided through the display 192 in real time, and check the amount of waste liquid filled in the waste liquid recovery container 50 at the appropriate time ( 50) can be emptied.

At this time, the radionuclide separation device 100 according to an embodiment of the present invention includes a stacker 160 for supporting the support plate 150 in the first space (S1) rather than the extraction space (S21). The support plate 150 may linearly reciprocate between the extraction space S21 and the first space S1 through linear movement.

For example, when the radionuclide separation apparatus 100 according to an embodiment of the present invention performs an extraction process for separating radionuclides from a sample, a support plate having at least one extract liquid recovery container 40 disposed on an upper surface thereof 150 may be disposed in the extraction space S21 (see FIG. 11).

In addition, when the radionuclide separation device 100 according to an embodiment of the present invention performs a cleaning process for cleaning the inside of the column through a cleaning liquid, the support plate 150 is formed from the first extraction space S21. By moving toward the stacker 160 provided in the space S1, waste liquid, such as a cleaning liquid falling from the column 10, may fall to the waste liquid recovery container 50 through the guide member 172 (see FIG. 12). ).

For example, the support plate 150 is linearly reciprocated along a horizontal direction through a second driving means, so that the extract liquid recovery container 40 is disposed at the lower side of the column 10 in the extraction space S21. Or move toward the stacker 160 provided in the first space S1.

Here, a mounting groove 151 is formed on the upper surface of the support plate 150 so that the extracting groove 40 is drawn into a predetermined depth so as to prevent the extract liquid collection container 40 from falling when the second driving means is linearly moved. Can be.

As a non-limiting example, the second driving means is a screw rod 154 that rotates through the driving of the fourth motor 153 and the screw rod during the rotation of the screw rod 154 as shown in FIG. It may include a loader 155 to reciprocate along the longitudinal direction of the screw rod 154.

As a result, when the loader 155 moves linearly through the driving of the fourth motor 153, the support plate 150 is driven by the loader 155 in the extraction space S21 in the first space S1. ) May be moved to the extraction space (S21) in the state loaded on the stacker 160 or loaded on the stacker 160.

At this time, the loader 155 side may be provided with fixing means for fixing the support plate 150 to smoothly move the support plate 150 from the first space (S1) to the extraction space (S21) side. Can be.

For example, an end of the loader 155 may be provided with an electromagnet 156, one side of the support plate 150 may be provided with a metal body 152 at a position corresponding to the electromagnet 156. .

In this case, the electromagnet 156 may be supplied with power or cut off from the power supply through the control of the controller 180.

Thus, the radionuclide separation device 100 according to an embodiment of the present invention is to move the support plate 150 loaded on the stacker 160 to the extraction space (S21) side, the electromagnet 156 The electromagnet 156 supplies power to the metal body 152 provided on the support plate 150 to supply power to the stacker through the loader 155 when the fourth motor 153 is driven. The support plate 150 loaded in 160 may be moved to the extraction space S21.

However, the fixing method of the loader 155 and the support plate 150 is not limited thereto, and a metal body having the electromagnet 156 provided on the support plate 150 may be supplied with power to the electromagnet 156. When the manpower is provided to the 152, the support plate 150 positioned in the extraction space S21 through the loader 155 when the fourth motor 153 is driven is the stacker 160 of the first space S1. You can also move to the side. In addition, the end of the loader 155 may be provided with a gripper (not shown) to operate through the control of the controller 180, the support plate 150 may be fixed by a grip method through the gripper In addition, the loader 155 may linearly move reciprocally when the fourth motor 153 is driven through a rack and pinion method.

Through this, in the radionuclide separation device 100 according to an embodiment of the present invention, as shown in FIGS. 10 to 12, the support plate 150 on which the at least one extract recovery container 40 is placed is driven by the second drive. By moving the means from the stacker 160 to the extraction space (S21) side is changed to the state where the extract liquid recovery container 40 is placed on the lower side of the column 10 or the support plate placed in the extraction space (S21) Since the 150 is moved from the extraction space S21 to the first space S1 side and automatically loaded in the stacker 160, a series of processes may be automatically performed.

On the other hand, the radionuclide separation device 100 according to an embodiment of the present invention may be formed of a structure in which the stacker 160 can be stacked in a plurality of support plates 150, the stacker 160 May be raised or lowered in the first space S1.

For example, the stacker 160 may be a frame structure formed in multiple stages as shown in FIG. 9, and a plurality of support plates 150 are stacked on the frame structure at predetermined intervals along a height direction. It may be in the form. In this case, the plurality of support plates 150 may be disposed in the extract liquid recovery container 40 on the upper surface.

In addition, the stacker 160 may reciprocate in the vertical direction through the third driving means. As a non-limiting example, the third driving means includes a fifth motor 161 fixed to one side of the stacker 160 and a pinion gear 162 coupled to the fifth motor 161 and the second pillar frame. The rack gear 163 geared to the pinion gear 162 and the guide 164 installed on one surface of the second pillar frame 114b on one surface of the 114b, and one side of the stacker 160 It may include a slider 165 coupled with.

As a result, when the fifth motor 161 is driven, the stacker 160 may transmit a driving force to the slider 165 through gear coupling between the pinion gear 162 and the rack gear 163. The slider 165 may be slidably moved in the up and down directions through a linear movement of the slider 165.

Accordingly, any one of the plurality of support plates 150 stacked in the stacker 160 in multiple stages may be positioned on a horizontal plane with the loader 155, and the stacker 160 may be disposed through the loader 155. From the extraction space (S21) to move from the extraction space (S21) may be recovered to the stacker 160 side.

Through this, the radionuclide separation device 100 according to an embodiment of the present invention selectively any one of a plurality of support plates 150 mounted on the stacker 160 through the movement of the stacker 160 By moving to the extraction space (S21) side or can be recovered to the stacker 160 side, a plurality of extraction process using the column 10 can be performed in a sequential automatic manner.

The controller 180 may control the radionuclide separation device 100 according to an embodiment of the present invention as a whole. The controller 180 may control a series of processes for extracting and washing radionuclides using the column 10.

For example, as shown in FIG. 5, the controller 180 may be an MCU and may be embedded in the upper body 111. In addition, the controller 180 may be in a state in which information about a series of processes for extracting and cleaning radionuclides using the column 10 has been previously input.

Through this, the radionuclide separation device 100 according to an embodiment of the present invention may be carried out in an automatic manner to separate the radionuclide using the column 10 through the drive of the controller 180.

Although one embodiment of the present invention has been described above, the spirit of the present invention is not limited to the embodiments set forth herein, and those skilled in the art who understand the spirit of the present invention may add components within the same scope. Other embodiments may be easily proposed by changing, deleting, adding, etc., but this will also fall within the spirit of the present invention.

100: radionuclide separation device
111: upper body 112: lower body
113: bottom plate 114a: first pillar frame
114b: second pillar frame 114c: partition frame
115: guide rod 116: support plate
117: flow controller 118: connector
120: holder portion 121: mounting hole
122: sealing member 123: first sensor
124: second sensor 130: manifold block
131: injection hole 132: protrusion
133: gas flow path 134: cylinder
134a: cylinder rod 141: suction part
142a: first housing 142b: first valve body
143a: storage space 143b: cylinder member
143c: piston member 144: first motor
145: second motor 146: distribution unit
147a: second housing 147b: second valve body
148: third motor 150: support plate
151: mounting groove 152: metal body
153: fourth motor 154: screw rod
155: loader 156: electromagnet
160: stacker 161: fifth motor
162: rack gear 163: pinion gear
164: Guide 165: Slider
170: waste liquid collection unit 172: guide member
173: outlet 180: control unit
191: pedestal 192: display
S1: first space S2: second space
S21: Extraction space S22: Collection space
10: column 12: resin
14 filter member 16 outlet
20: reagent container 30: cleaning liquid container
40: extract liquid recovery container 50: waste liquid recovery container
61: first tube 62: second tube
63: third tube

Claims (14)

delete A holder portion to which at least one column for extracting a predetermined radionuclide from a sample is mounted;
A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column;
A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole;
At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column;
A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column; And
A control unit for controlling the overall driving;
The holder portion includes a mounting hole formed so that the upper portion of the column can be mounted in the state in which the column is inserted, wherein the mounting hole is a radionuclide separation device is disposed along the rim. A holder portion to which at least one column for extracting a predetermined radionuclide from a sample is mounted;
A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column;
A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole;
At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column;
A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column; And
A control unit for controlling the overall driving;
The reagent or the cleaning liquid is moved into the column through the injection hole while the manifold block covers the open top of the column by driving the first driving means,
The manifold block includes a hollow protrusion protruding a predetermined length to surround the injection hole on the lower surface, the open top of the column is separated by radionuclides covered by the protrusion when the manifold block descends Device. A holder portion to which at least one column for extracting a predetermined radionuclide from a sample is mounted;
A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column;
A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole;
At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column;
A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column; And
A control unit for controlling the overall driving;
The manifold block includes a gas movement path formed to communicate with the injection hole,
The gas movement path is connected to a flow controller for controlling the flow rate of the compressor body supplied from the compressor body supply means,
Compressor body supplied through the flow controller is a radionuclide separation device is supplied to the inside of the column through the gas movement path and the injection hole. The method of claim 4, wherein
Compressor body supplied from the compressor body supply means to the flow controller is a radionuclide separation device is a compressor body pressure controlled through a regulator. A holder portion to which at least one column for extracting a predetermined radionuclide from a sample is mounted;
A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column;
A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole;
At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column;
A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column;
A control unit for controlling the overall driving; And
And at least one sensor for checking the extraction state of the sample and the reagent passing through the inside of the column,
The sensor is disposed in the middle of the length of the column and the first sensor for measuring the height of the sample and the reagent passing through the column and the outlet side of the column to detect the state of the discharge liquid falling from the column Radionuclide separation device comprising at least one of the second sensor for. delete A holder portion to which at least one column for extracting a predetermined radionuclide from a sample is mounted;
A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column;
A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole;
At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column;
A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column; And
A control unit for controlling the overall driving;
The supply unit,
At least one suction part connected to the reagent container and the cleaning liquid container via a plurality of first tubes, respectively, to suck a predetermined amount of the reagent or the cleaning liquid from the reagent container and the cleaning liquid container, and a plurality of columns mounted to the holder part; It includes a plurality of injection holes formed in the manifold block to correspond to the plurality of columns,
The supply unit,
The suction unit and the second tube are connected to each other, and the plurality of injection holes and the plurality of third tubes are connected one-to-one, and the reagent or cleaning solution supplied from the second tube is selected from the plurality of injection holes. Radionuclide separation device further comprises a distribution unit for supplying to one injection hole side. The method of claim 8,
The supply part includes a plurality of suction parts,
The plurality of suction portions are directly connected to at least one injection hole of the plurality of injection holes formed in the manifold block to simultaneously supply reagents or cleaning liquids sucked from the reagent container and the cleaning liquid container to the plurality of column sides mounted on the holder part. Radionuclide Separation Device. delete The method of claim 8,
The radionuclide separation device,
The supply part includes a plurality of suction parts and a plurality of distribution parts connected one to one via the plurality of suction parts and the second tube,
The plurality of suction portions are connected to each suction portion at the same time through one reagent vessel or a washing liquid vessel and the first tube,
Each of the plurality of distribution parts may be connected to each of the plurality of injection holes of the plurality of injection holes formed in the manifold block and the third tube,
The injection hole connected via the first distribution unit and the third tube of the plurality of distribution units is a radionuclide separation device that is different from the injection hole connected via the second distribution unit and the third tube. A holder portion to which at least one column for extracting a predetermined radionuclide from a sample is mounted;
A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column;
A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole;
At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column;
A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column;
A control unit for controlling the overall driving;
A plurality of support plates each having at least one extract liquid recovery container disposed on an upper surface thereof; And
And a plurality of support plates at which the stackers are spaced apart at intervals along the height direction.
The stacker is a radionuclide separation device that is reciprocated in the vertical direction through the third drive means. The method of claim 12,
The radionuclide separation device,
And a loader reciprocated along a horizontal direction through the driving of the second driving means, wherein the support plate is disposed at the lower side of the column or moved to the stacker side through the loader. A holder portion to which at least one column for extracting a predetermined radionuclide from a sample is mounted;
A manifold block disposed on the upper side of the holder part so as to be moved up and down by driving the first driving means and having an injection hole formed at a position corresponding to the column;
A supply unit for sucking a predetermined amount of a reagent or a cleaning solution from at least one reagent container and a cleaning solution container and supplying the inside of the column through the injection hole;
At least one extractor collecting vessel for collecting the discharged liquid discharged from the column is disposed on the upper surface, and is linearly reciprocated along a horizontal direction by the driving of the second driving means to move the extractant collecting vessel to the lower side of the column. A support plate disposed in or detached from the lower side of the column;
A waste liquid collection unit disposed at a lower side of the column, for collecting waste liquid discharged from the column; And
A control unit for controlling the overall driving;
The waste liquid collection part includes a waste liquid recovery container for storing the waste liquid dropped from the column, and a guide member disposed at an upper side of the waste liquid recovery container to guide the waste liquid falling from the column to the inlet of the waste liquid recovery container. and,
The guide member is a radionuclide separation device is a funnel member, the upper and lower portions are opened and the cross-sectional area is reduced from the top to the bottom.

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