KR102056257B1 - 베타-턴 펩티도미메틱 사이클릭 염의 용액상 합성 및 결정화 - Google Patents

베타-턴 펩티도미메틱 사이클릭 염의 용액상 합성 및 결정화 Download PDF

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KR102056257B1
KR102056257B1 KR1020187003965A KR20187003965A KR102056257B1 KR 102056257 B1 KR102056257 B1 KR 102056257B1 KR 1020187003965 A KR1020187003965 A KR 1020187003965A KR 20187003965 A KR20187003965 A KR 20187003965A KR 102056257 B1 KR102056257 B1 KR 102056257B1
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formula
compound
side chain
salt
hcl
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KR20180036982A (ko
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찬탈 데빈
웨이 티안
마르틴 보린
세바스티엔 로키
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미메토젠 파르마슈티칼스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187003965A 2015-07-09 2016-07-08 베타-턴 펩티도미메틱 사이클릭 염의 용액상 합성 및 결정화 Active KR102056257B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562190596P 2015-07-09 2015-07-09
US62/190,596 2015-07-09
PCT/EP2016/066281 WO2017005902A1 (en) 2015-07-09 2016-07-08 Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts

Publications (2)

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KR20180036982A KR20180036982A (ko) 2018-04-10
KR102056257B1 true KR102056257B1 (ko) 2019-12-16

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US (4) US10125165B2 (enExample)
EP (2) EP3319978B1 (enExample)
JP (1) JP6801835B2 (enExample)
KR (1) KR102056257B1 (enExample)
CN (2) CN107849089B (enExample)
AU (1) AU2016290654C1 (enExample)
TW (1) TWI708779B (enExample)
WO (1) WO2017005902A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102056257B1 (ko) * 2015-07-09 2019-12-16 미메토젠 파르마슈티칼스 인크. 베타-턴 펩티도미메틱 사이클릭 염의 용액상 합성 및 결정화
SI3464336T1 (sl) 2016-06-01 2022-06-30 Athira Pharma, Inc. Spojine
KR102826649B1 (ko) * 2018-05-31 2025-06-30 쎄데르마 용액-상 펩티드의 합성 방법 및 그에 따른 보호 전략
US11427612B2 (en) * 2018-08-21 2022-08-30 Wayne State University Epimerization-free N to C solid-phase peptide synthesis
CN117279928A (zh) * 2021-05-07 2023-12-22 中外制药株式会社 包含n-取代氨基酸残基的环状化合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP254898A0 (en) * 1998-03-24 1998-04-23 University Of Queensland, The Peptide turn mimetics
WO2001052843A1 (en) 2000-01-18 2001-07-26 Mcgill University β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS
HRP20041179B1 (hr) * 2002-06-11 2012-11-30 Eli Lilly And Company Prekursorski oblici lijekova za aminokiseline s pobuđivačkom aktivnosti
AU2009232352B2 (en) * 2008-04-04 2013-09-05 Mimetogen Pharmaceuticals Inc. Beta-turn peptidomimetic cyclic compounds for treating dry eye
AU2010217889B2 (en) * 2009-02-27 2014-12-18 Mimetogen Pharmaceuticals Inc. Peptidomimetic cyclic compounds for treating retinitis pigmentosa
EP2598604B1 (de) * 2010-07-29 2015-11-25 Merck Patent GmbH Flüssigkristallines medium enthaltend thiophenderivate
JP5710436B2 (ja) * 2011-09-26 2015-04-30 株式会社東芝 パターン形成方法
EP2864347B1 (en) * 2012-06-22 2020-10-28 Mimetogen Pharmaceuticals, Inc. Synthesis of beta-turn peptidomimetic cyclic compounds
JP6516974B2 (ja) * 2013-06-14 2019-05-22 豊田合成株式会社 ゴム組成物及びゴム製品
CN105142777B (zh) * 2013-06-20 2017-12-26 埃克森美孚化学专利公司 长桥Salen催化剂
KR102056257B1 (ko) * 2015-07-09 2019-12-16 미메토젠 파르마슈티칼스 인크. 베타-턴 펩티도미메틱 사이클릭 염의 용액상 합성 및 결정화

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J Org Chem.,71:6814-6821(2006.8.10.)
Mar Drugs.,3(5):3029-3045(2015.5.15.)

Also Published As

Publication number Publication date
CN114874288A (zh) 2022-08-09
WO2017005902A1 (en) 2017-01-12
TWI708779B (zh) 2020-11-01
JP6801835B2 (ja) 2020-12-16
AU2016290654A2 (en) 2020-08-06
AU2016290654A1 (en) 2018-01-25
EP3319978C0 (en) 2025-02-19
EP4549450A2 (en) 2025-05-07
US20230357318A1 (en) 2023-11-09
US12281179B2 (en) 2025-04-22
CN107849089B (zh) 2022-07-05
AU2016290654C1 (en) 2021-11-11
US20170008923A1 (en) 2017-01-12
KR20180036982A (ko) 2018-04-10
US11078234B2 (en) 2021-08-03
TW201716425A (zh) 2017-05-16
AU2016290654B2 (en) 2021-07-08
CN107849089A (zh) 2018-03-27
US11753441B2 (en) 2023-09-12
HK1255355A1 (en) 2019-08-16
CA2991661A1 (en) 2017-01-12
EP3319978A1 (en) 2018-05-16
EP4549450A3 (en) 2025-07-02
US20190194251A1 (en) 2019-06-27
US20210300966A1 (en) 2021-09-30
US10125165B2 (en) 2018-11-13
EP3319978B1 (en) 2025-02-19
JP2018528928A (ja) 2018-10-04

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