KR102046449B1 - 효모-브라큐리 면역요법 조성물 - Google Patents

효모-브라큐리 면역요법 조성물 Download PDF

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KR102046449B1
KR102046449B1 KR1020137027169A KR20137027169A KR102046449B1 KR 102046449 B1 KR102046449 B1 KR 102046449B1 KR 1020137027169 A KR1020137027169 A KR 1020137027169A KR 20137027169 A KR20137027169 A KR 20137027169A KR 102046449 B1 KR102046449 B1 KR 102046449B1
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yeast
brachyury
cancer
seq
antigen
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KR20140038387A (ko
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클라우디아 팔레나
지민 궈
데이비드 아펠리언
제프리 슈롬
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글로브이뮨
더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/06Fungi, e.g. yeasts
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    • A61K40/00Cellular immunotherapy
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KR1020137027169A 2011-03-17 2012-03-19 효모-브라큐리 면역요법 조성물 Active KR102046449B1 (ko)

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Application Number Priority Date Filing Date Title
US201161453656P 2011-03-17 2011-03-17
US61/453,656 2011-03-17
PCT/US2012/029636 WO2012125998A1 (en) 2011-03-17 2012-03-19 Yeast-brachyury immunotherapeutic compositions

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KR20140038387A KR20140038387A (ko) 2014-03-28
KR102046449B1 true KR102046449B1 (ko) 2019-11-19

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US (5) US9198941B2 (enExample)
EP (2) EP3238731B1 (enExample)
JP (4) JP6068368B2 (enExample)
KR (1) KR102046449B1 (enExample)
CN (1) CN103648513B (enExample)
AU (3) AU2012228937B2 (enExample)
BR (1) BR112013023456B1 (enExample)
CA (1) CA2835475C (enExample)
DK (1) DK2685995T3 (enExample)
ES (1) ES2627979T3 (enExample)
HK (1) HK1245649A1 (enExample)
HU (1) HUE033491T2 (enExample)
IL (1) IL228421B (enExample)
MX (1) MX350661B (enExample)
PL (1) PL2685995T3 (enExample)
PT (1) PT2685995T (enExample)
RU (2) RU2690180C2 (enExample)
SG (2) SG193396A1 (enExample)
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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3061462B1 (en) 2007-07-02 2019-02-27 Etubics Corporation Methods and compositions for producing an adenovirus vector for use with multiple vaccinations
EP2651439B1 (en) 2010-12-17 2018-09-19 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human adenovirus-36 infection
AU2012214394B2 (en) 2011-02-12 2016-08-11 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis B infection
JP6068368B2 (ja) 2011-03-17 2017-01-25 グローブイミューン,インコーポレイテッド 酵母−ブラキュリ免疫治療組成物
CA2838950C (en) 2011-06-14 2020-10-27 Globeimmune, Inc. Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection
CA2844500C (en) 2011-08-17 2022-05-10 Globeimmune, Inc. Yeast-muc1 immunotherapeutic compositions and uses thereof
WO2014003853A1 (en) 2012-06-26 2014-01-03 Biodesix, Inc. Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies
WO2014031178A1 (en) 2012-08-24 2014-02-27 Etubics Corporation Replication defective adenovirus vector in vaccination
EP2895191B1 (en) 2012-09-14 2019-06-05 The U.S.A. as represented by the Secretary, Department of Health and Human Services Brachyury protein, adenoviral vectors encoding brachyury protein, and their use
CA2907560C (en) * 2013-03-19 2021-12-07 Timothy C. Rodell Yeast-based immunotherapy for chordoma
US9782473B2 (en) 2013-03-26 2017-10-10 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
US9725494B2 (en) * 2013-05-17 2017-08-08 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Soluble CD27 (sCD27) and the use thereof
WO2015031778A2 (en) 2013-08-30 2015-03-05 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
WO2015157639A1 (en) 2014-04-11 2015-10-15 Globeimmune, Inc. Yeast-based immunotherapy and type i interferon sensitivity
JP6647315B2 (ja) 2015-01-09 2020-02-14 イーチュービクス コーポレイション 組み合わせ免疫療法のための方法および組成物
EP3286213B1 (en) 2015-04-20 2021-08-04 Etubics Corporation Methods and compositions for combination immunotherapy
AU2016303525B2 (en) * 2015-08-03 2021-01-21 Globeimmune, Inc. Modified yeast-Brachyury immunotherapeutic compositions
JP7048482B2 (ja) * 2015-08-03 2022-04-05 アメリカ合衆国 Brachyury欠失変異体、Brachyury欠失変異体をコードする非酵母ベクター、及びそれらの使用
AU2017281126A1 (en) 2016-03-24 2018-10-04 Nant Holdings Ip, Llc Sequence arrangements and sequences for neoepitope presentation
US20190125852A1 (en) * 2016-06-03 2019-05-02 Etubics Corporation Compositions and methods for tumor vaccination using prostate cancer-associated antigens
EP3541400B1 (en) * 2016-11-18 2025-05-14 Sanford Burnham Prebys Medical Discovery Institute Gut microbiota and treatment of cancer
IL270132B2 (en) 2017-04-24 2024-12-01 Nantcell Inc Neoepitope vectors and methods for them
WO2019036485A1 (en) * 2017-08-15 2019-02-21 Nantcell, Inc. ASSOCIATIONS OF CÉTUXIMAB AND HIGH AFFINITY NATURAL KILLER CELLS AND ASSOCIATED METHODS
CN112543640B (zh) 2018-05-15 2025-02-14 全球免疫公司 用于诱导细胞免疫应答的重组酵母裂解物
US11857620B2 (en) 2020-03-11 2024-01-02 Immunitybio, Inc. Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus
US20210284716A1 (en) 2020-03-11 2021-09-16 Immunitybio, Inc. ACE2-Fc Trap
US12285480B2 (en) 2020-03-11 2025-04-29 Nantcell, Inc. Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses
WO2022178218A1 (en) 2021-02-19 2022-08-25 Mevion Medical Systems, Inc. Gantry for a particle therapy system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010121180A1 (en) * 2009-04-17 2010-10-21 Globeimmune, Inc. Combination immunotherapy compositions against cancer and methods

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1036329A (en) 1908-11-19 1912-08-20 Edison Inc Thomas A Phonograph-reproducer.
FR2486400B1 (fr) 1980-07-09 1986-05-30 Univablot Medicaments a base de levures ou de leurs extraits insolubles
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4775622A (en) 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5310654A (en) 1985-07-31 1994-05-10 The Board Of Trustees Of The Leland Stanford Junior University Method for determining virulence of Yersinia
US5234830A (en) 1988-02-03 1993-08-10 Suntory Limited DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region
IL95019A0 (en) 1989-08-09 1991-06-10 Mycogen Corp Process for encapsulation of biologicals
US5413914A (en) 1993-07-07 1995-05-09 The Regents Of The University Of Colorado Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases
US5830463A (en) 1993-07-07 1998-11-03 University Technology Corporation Yeast-based delivery vehicles
US5858378A (en) 1996-05-02 1999-01-12 Galagen, Inc. Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen
US20020044948A1 (en) 2000-03-15 2002-04-18 Samir Khleif Methods and compositions for co-stimulation of immunological responses to peptide antigens
ATE319475T1 (de) 2000-04-06 2006-03-15 Seer Pharmaceuticals Llc Microbielles wirkstoffabgabesystem
US7083787B2 (en) 2000-11-15 2006-08-01 Globeimmune, Inc. Yeast-dendritic cell vaccines and uses thereof
US7439042B2 (en) 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
CN102370974B (zh) 2002-12-16 2014-09-17 全球免疫股份有限公司 用于免疫治疗的基于酵母的疫苗
CN101262883A (zh) 2005-07-11 2008-09-10 环球免疫公司 引发针对靶向的疗法的逃逸突变体的免疫应答的组合物和方法
US20070172503A1 (en) 2005-12-13 2007-07-26 Mycologics,Inc. Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines
KR20140029551A (ko) 2006-02-02 2014-03-10 글로브이뮨 면역 반응 유도를 위한 효모-기반 백신
BRPI0709340A2 (pt) * 2006-03-27 2013-04-16 Globeimmune Inc mutaÇço ras e composiÇÕes e mÉtodos de uso da mesma
JP5570819B2 (ja) 2007-02-02 2014-08-13 グローブイミューン,インコーポレイテッド 酵母を含む組成物および酵母を増殖させる方法
JP5596980B2 (ja) * 2007-02-28 2014-10-01 アメリカ合衆国 ブラキュリポリペプチドおよび使用方法
MX2009010066A (es) 2007-03-19 2009-10-12 Globeimmune Inc Composiciones y metodos para la ablacion especifica de la evasion mutacional de terapias especificas para cancer.
WO2009042645A2 (en) 2007-09-24 2009-04-02 President And Fellows Of Harvard College The use of mice predisposed to develop ulcerative colitis and colon cancer to develop metabolic profiles associated with same
US8728489B2 (en) 2008-09-19 2014-05-20 Globeimmune, Inc. Immunotherapy for chronic hepatitis C virus infection
WO2010065626A1 (en) 2008-12-02 2010-06-10 Globeimmune, Inc. Genotyping tools, methods and kits
JP5913103B2 (ja) 2009-09-14 2016-04-27 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法
EP2547792A4 (en) 2010-03-14 2013-11-27 Globeimmune Inc PHARMACOGENOMIC TREATMENT AND ADAPTATION TO THE RESPONSE OF AN INFECTIOUS DISEASE USING YEAST IMMUNOTHERAPY
WO2012019127A2 (en) * 2010-08-05 2012-02-09 The Regents Of The University Of Colorado Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases
EP2651439B1 (en) 2010-12-17 2018-09-19 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human adenovirus-36 infection
AU2012214394B2 (en) 2011-02-12 2016-08-11 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis B infection
JP6068368B2 (ja) 2011-03-17 2017-01-25 グローブイミューン,インコーポレイテッド 酵母−ブラキュリ免疫治療組成物
CA2838950C (en) 2011-06-14 2020-10-27 Globeimmune, Inc. Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection
CA2844500C (en) 2011-08-17 2022-05-10 Globeimmune, Inc. Yeast-muc1 immunotherapeutic compositions and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010121180A1 (en) * 2009-04-17 2010-10-21 Globeimmune, Inc. Combination immunotherapy compositions against cancer and methods

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US20170246276A1 (en) 2017-08-31
US9623097B2 (en) 2017-04-18
AU2017200715B2 (en) 2018-05-31
AU2018202972A1 (en) 2018-05-17
US20160106824A1 (en) 2016-04-21
RU2690180C2 (ru) 2019-05-31
BR112013023456A2 (pt) 2016-12-06
WO2012125998A1 (en) 2012-09-20
HK1245649A1 (en) 2018-08-31
US11944673B2 (en) 2024-04-02
CA2835475C (en) 2020-06-30
ES2627979T3 (es) 2017-08-01
EP3238731A1 (en) 2017-11-01
IL228421B (en) 2019-02-28
US20190374624A1 (en) 2019-12-12
US20210106666A1 (en) 2021-04-15
EP3238731B1 (en) 2021-02-17
IL228421A0 (en) 2013-12-31
JP6580733B2 (ja) 2019-09-25
US10363294B2 (en) 2019-07-30
AU2018202972B2 (en) 2019-08-29
SG193396A1 (en) 2013-10-30
EP2685995A4 (en) 2014-12-24
MX2013010475A (es) 2014-05-28
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EP2685995B1 (en) 2017-05-03
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JP2019199484A (ja) 2019-11-21
SG10201601913RA (en) 2016-05-30
JP2017061570A (ja) 2017-03-30
KR20140038387A (ko) 2014-03-28
EP2685995A1 (en) 2014-01-22
CN103648513B (zh) 2018-10-12
AU2012228937A1 (en) 2013-10-31
AU2017200715A1 (en) 2017-02-23
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JP2014509595A (ja) 2014-04-21
US11938175B2 (en) 2024-03-26
DK2685995T3 (en) 2017-08-21
RU2017116350A3 (enExample) 2018-10-17
NZ616696A (en) 2015-09-25
BR112013023456B1 (pt) 2020-11-17
PL2685995T3 (pl) 2017-10-31
US9198941B2 (en) 2015-12-01
JP6068368B2 (ja) 2017-01-25
RU2619850C2 (ru) 2017-05-18
PT2685995T (pt) 2017-08-09
AU2012228937B2 (en) 2016-11-03
CA2835475A1 (en) 2012-09-20
RU2013146324A (ru) 2015-04-27
RU2017116350A (ru) 2018-10-17
HUE033491T2 (en) 2017-12-28
CN103648513A (zh) 2014-03-19
JP6309607B2 (ja) 2018-04-11

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