KR102040307B1 - 암과 연관된 유전적 또는 분자적 이상들의 검출 - Google Patents
암과 연관된 유전적 또는 분자적 이상들의 검출 Download PDFInfo
- Publication number
- KR102040307B1 KR102040307B1 KR1020187023415A KR20187023415A KR102040307B1 KR 102040307 B1 KR102040307 B1 KR 102040307B1 KR 1020187023415 A KR1020187023415 A KR 1020187023415A KR 20187023415 A KR20187023415 A KR 20187023415A KR 102040307 B1 KR102040307 B1 KR 102040307B1
- Authority
- KR
- South Korea
- Prior art keywords
- cancer
- chromosomal
- sites
- statistical value
- site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 390
- 201000011510 cancer Diseases 0.000 title claims abstract description 192
- 230000004075 alteration Effects 0.000 title abstract description 9
- 230000002068 genetic effect Effects 0.000 title abstract description 6
- 238000001514 detection method Methods 0.000 title description 24
- 230000002759 chromosomal effect Effects 0.000 claims abstract description 152
- 238000000034 method Methods 0.000 claims abstract description 138
- 210000000349 chromosome Anatomy 0.000 claims abstract description 134
- 238000004458 analytical method Methods 0.000 claims abstract description 92
- 230000003321 amplification Effects 0.000 claims abstract description 90
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 90
- 238000012217 deletion Methods 0.000 claims abstract description 75
- 230000037430 deletion Effects 0.000 claims abstract description 75
- 239000012472 biological sample Substances 0.000 claims abstract description 41
- 238000004393 prognosis Methods 0.000 claims abstract description 18
- 230000001747 exhibiting effect Effects 0.000 claims abstract description 6
- 208000006994 Precancerous Conditions Diseases 0.000 claims abstract description 5
- 210000001519 tissue Anatomy 0.000 claims description 80
- 150000007523 nucleic acids Chemical class 0.000 claims description 79
- 238000009826 distribution Methods 0.000 claims description 76
- 102000039446 nucleic acids Human genes 0.000 claims description 71
- 108020004707 nucleic acids Proteins 0.000 claims description 71
- 210000004027 cell Anatomy 0.000 claims description 67
- 238000012544 monitoring process Methods 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 8
- 230000003902 lesion Effects 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims description 4
- 206010061764 Chromosomal deletion Diseases 0.000 claims description 2
- 238000000692 Student's t-test Methods 0.000 claims description 2
- 238000000546 chi-square test Methods 0.000 claims description 2
- 238000012353 t test Methods 0.000 claims description 2
- 238000010224 classification analysis Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 abstract description 180
- 230000009897 systematic effect Effects 0.000 abstract description 6
- 108020004414 DNA Proteins 0.000 description 243
- 102000053602 DNA Human genes 0.000 description 241
- 102000054766 genetic haplotypes Human genes 0.000 description 175
- 108700028369 Alleles Proteins 0.000 description 96
- 230000005856 abnormality Effects 0.000 description 80
- 239000000523 sample Substances 0.000 description 60
- 208000031404 Chromosome Aberrations Diseases 0.000 description 59
- 206010008805 Chromosomal abnormalities Diseases 0.000 description 52
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 48
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 47
- 238000012163 sequencing technique Methods 0.000 description 37
- 230000001186 cumulative effect Effects 0.000 description 36
- 238000013459 approach Methods 0.000 description 18
- 238000013519 translation Methods 0.000 description 17
- 230000014616 translation Effects 0.000 description 17
- 230000002159 abnormal effect Effects 0.000 description 16
- 230000008859 change Effects 0.000 description 14
- 230000000875 corresponding effect Effects 0.000 description 14
- 238000005259 measurement Methods 0.000 description 13
- 230000001613 neoplastic effect Effects 0.000 description 13
- 238000002271 resection Methods 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 230000002018 overexpression Effects 0.000 description 11
- 230000009452 underexpressoin Effects 0.000 description 11
- 238000007847 digital PCR Methods 0.000 description 10
- 201000010099 disease Diseases 0.000 description 10
- 230000035945 sensitivity Effects 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 9
- 239000002773 nucleotide Substances 0.000 description 9
- 125000003729 nucleotide group Chemical group 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 206010061818 Disease progression Diseases 0.000 description 8
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 8
- 230000005750 disease progression Effects 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 210000004881 tumor cell Anatomy 0.000 description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 6
- 238000003205 genotyping method Methods 0.000 description 6
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 238000010208 microarray analysis Methods 0.000 description 5
- 238000003752 polymerase chain reaction Methods 0.000 description 5
- 230000010076 replication Effects 0.000 description 5
- 238000004904 shortening Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000001165 lymph node Anatomy 0.000 description 4
- 238000010606 normalization Methods 0.000 description 4
- 102000054765 polymorphisms of proteins Human genes 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 3
- 206010061309 Neoplasm progression Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000001594 aberrant effect Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 230000002596 correlated effect Effects 0.000 description 3
- 238000001784 detoxification Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 230000008774 maternal effect Effects 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 229920002477 rna polymer Polymers 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 230000005751 tumor progression Effects 0.000 description 3
- 208000000419 Chronic Hepatitis B Diseases 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 241000700721 Hepatitis B virus Species 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 2
- 108700011259 MicroRNAs Proteins 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 108091027967 Small hairpin RNA Proteins 0.000 description 2
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 2
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 231100000005 chromosome aberration Toxicity 0.000 description 2
- 230000007882 cirrhosis Effects 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 230000002559 cytogenic effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002224 dissection Methods 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000004077 genetic alteration Effects 0.000 description 2
- 238000011331 genomic analysis Methods 0.000 description 2
- 201000010536 head and neck cancer Diseases 0.000 description 2
- 208000014829 head and neck neoplasm Diseases 0.000 description 2
- 208000002672 hepatitis B Diseases 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000005155 neural progenitor cell Anatomy 0.000 description 2
- 210000004882 non-tumor cell Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 238000002626 targeted therapy Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 230000001173 tumoral effect Effects 0.000 description 2
- VGONTNSXDCQUGY-RRKCRQDMSA-N 2'-deoxyinosine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC2=O)=C2N=C1 VGONTNSXDCQUGY-RRKCRQDMSA-N 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 206010067477 Cytogenetic abnormality Diseases 0.000 description 1
- 238000013382 DNA quantification Methods 0.000 description 1
- 102000001301 EGF receptor Human genes 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 108091007412 Piwi-interacting RNA Proteins 0.000 description 1
- 240000003705 Senecio vulgaris Species 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000007844 allele-specific PCR Methods 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 208000019065 cervical carcinoma Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- 230000037442 genomic alteration Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000003917 human chromosome Anatomy 0.000 description 1
- 230000002998 immunogenetic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000001531 micro-dissection Methods 0.000 description 1
- 238000007479 molecular analysis Methods 0.000 description 1
- 238000007838 multiplex ligation-dependent probe amplification Methods 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 108091027963 non-coding RNA Proteins 0.000 description 1
- 102000042567 non-coding RNA Human genes 0.000 description 1
- 238000009595 pap smear Methods 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007841 sequencing by ligation Methods 0.000 description 1
- 210000003765 sex chromosome Anatomy 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Algebra (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Analysis (AREA)
- Mathematical Optimization (AREA)
- Mathematical Physics (AREA)
- Pure & Applied Mathematics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41839110P | 2010-11-30 | 2010-11-30 | |
| US61/418,391 | 2010-11-30 | ||
| US201161529877P | 2011-08-31 | 2011-08-31 | |
| US61/529,877 | 2011-08-31 | ||
| PCT/AU2011/001562 WO2012071621A1 (en) | 2010-11-30 | 2011-11-30 | Detection of genetic or molecular aberrations associated with cancer |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137016780A Division KR101891847B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197032092A Division KR102185244B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180095941A KR20180095941A (ko) | 2018-08-28 |
| KR102040307B1 true KR102040307B1 (ko) | 2019-11-27 |
Family
ID=46171096
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137016780A Active KR101891847B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020207033400A Active KR102333664B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020217038741A Active KR102489749B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020237001326A Active KR102723107B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020197032092A Active KR102185244B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020187023415A Active KR102040307B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137016780A Active KR101891847B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020207033400A Active KR102333664B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020217038741A Active KR102489749B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020237001326A Active KR102723107B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| KR1020197032092A Active KR102185244B1 (ko) | 2010-11-30 | 2011-11-30 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US8741811B2 (enExample) |
| EP (4) | EP3640346A1 (enExample) |
| JP (5) | JP6196157B2 (enExample) |
| KR (6) | KR101891847B1 (enExample) |
| CN (4) | CN103403182B (enExample) |
| AU (1) | AU2011335891B2 (enExample) |
| BR (1) | BR112013013421A2 (enExample) |
| CA (1) | CA2817370C (enExample) |
| DK (2) | DK3243910T3 (enExample) |
| EA (1) | EA038374B1 (enExample) |
| IL (3) | IL226272A (enExample) |
| MX (3) | MX349568B (enExample) |
| MY (1) | MY169852A (enExample) |
| NZ (1) | NZ611599A (enExample) |
| SG (3) | SG10201509766YA (enExample) |
| TW (5) | TWI786520B (enExample) |
| WO (1) | WO2012071621A1 (enExample) |
| ZA (1) | ZA201304625B (enExample) |
Families Citing this family (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| KR102222378B1 (ko) | 2007-07-23 | 2021-03-04 | 더 차이니즈 유니버시티 오브 홍콩 | 핵산 서열 불균형의 결정 |
| US20110178719A1 (en) | 2008-08-04 | 2011-07-21 | Gene Security Network, Inc. | Methods for Allele Calling and Ploidy Calling |
| EP2473638B1 (en) | 2009-09-30 | 2017-08-09 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| WO2011090556A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
| US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
| EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| EP2848704B1 (en) | 2010-01-19 | 2018-08-29 | Verinata Health, Inc | Sequencing methods for prenatal diagnoses |
| US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| CA2786565C (en) | 2010-01-19 | 2017-04-25 | Verinata Health, Inc. | Partition defined detection methods |
| US8825412B2 (en) | 2010-05-18 | 2014-09-02 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| KR101891847B1 (ko) | 2010-11-30 | 2018-08-24 | 더 차이니즈 유니버시티 오브 홍콩 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| CA2821906C (en) | 2010-12-22 | 2020-08-25 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| EP2673380B1 (en) * | 2011-02-09 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Analysis of nucleic acids |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| RS57837B1 (sr) | 2011-04-12 | 2018-12-31 | Verinata Health Inc | Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama |
| AU2012242847B2 (en) | 2011-04-15 | 2017-01-19 | The Johns Hopkins University | Safe sequencing system |
| US9411937B2 (en) * | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US9605313B2 (en) | 2012-03-02 | 2017-03-28 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| WO2013138510A1 (en) | 2012-03-13 | 2013-09-19 | Patel Abhijit Ajit | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| CA2878246C (en) * | 2012-07-20 | 2022-01-11 | Verinata Health, Inc. | Detecting and classifying copy number variation in a cancer genome |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP4036247B1 (en) | 2012-09-04 | 2024-04-10 | Guardant Health, Inc. | Methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| LT3354747T (lt) | 2012-09-20 | 2021-04-12 | The Chinese University Of Hong Kong | Neinvazinis naviko metilomos nustatymas iš plazmos |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP2912468B1 (en) | 2012-10-29 | 2018-09-12 | The Johns Hopkins University | Papanicolaou test for ovarian and endometrial cancers |
| WO2014093330A1 (en) | 2012-12-10 | 2014-06-19 | Clearfork Bioscience, Inc. | Methods for targeted genomic analysis |
| US10643738B2 (en) | 2013-01-10 | 2020-05-05 | The Chinese University Of Hong Kong | Noninvasive prenatal molecular karyotyping from maternal plasma |
| EP2971100A1 (en) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primers for dna methylation analysis |
| EP3421613B1 (en) * | 2013-03-15 | 2020-08-19 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| WO2014190286A2 (en) | 2013-05-24 | 2014-11-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3024948B1 (en) | 2013-07-25 | 2020-01-15 | Bio-rad Laboratories, Inc. | Genetic assays for detecting viral recombination rate |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| US9499870B2 (en) | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| US10851414B2 (en) * | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| CA2928185C (en) * | 2013-10-21 | 2024-01-30 | Verinata Health, Inc. | Method for improving the sensitivity of detection in determining copy number variations |
| SG10201804519RA (en) | 2013-12-28 | 2018-07-30 | Guardant Health Inc | Methods and systems for detecting genetic variants |
| US11365447B2 (en) | 2014-03-13 | 2022-06-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
| WO2015164432A1 (en) * | 2014-04-21 | 2015-10-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3149199B1 (en) | 2014-05-30 | 2020-03-25 | Verinata Health, Inc. | Detecting, optionally fetal, sub-chromosomal aneuploidies and copy number variations |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| TWI895765B (zh) * | 2014-07-18 | 2025-09-01 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| KR102696857B1 (ko) | 2014-07-25 | 2024-08-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| EP3175000B1 (en) | 2014-07-30 | 2020-07-29 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2016025818A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| CN107750277B (zh) | 2014-12-12 | 2021-11-09 | 维里纳塔健康股份有限公司 | 使用无细胞dna片段大小来确定拷贝数变化 |
| US10364467B2 (en) * | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US11242559B2 (en) | 2015-01-13 | 2022-02-08 | The Chinese University Of Hong Kong | Method of nuclear DNA and mitochondrial DNA analysis |
| US10319463B2 (en) * | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
| CA2976303A1 (en) | 2015-02-10 | 2016-08-18 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| CN106021992A (zh) * | 2015-03-27 | 2016-10-12 | 知源生信公司(美国硅谷) | 位置相关变体识别计算流水线 |
| KR20170134641A (ko) * | 2015-04-10 | 2017-12-06 | 샤카이후쿠시호진 온시자이단사이세이카이 | 간 질환의 병태를 판별하는 방법 |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| CN108138233B (zh) | 2015-07-20 | 2022-08-26 | 香港中文大学 | Dna混合物中组织的单倍型的甲基化模式分析 |
| HUE057821T2 (hu) | 2015-07-23 | 2022-06-28 | Univ Hong Kong Chinese | Sejtmentes DNS fragmentációs mintázatának elemzése |
| JP6675164B2 (ja) * | 2015-07-28 | 2020-04-01 | 株式会社理研ジェネシス | 変異判定方法、変異判定プログラムおよび記録媒体 |
| WO2017027653A1 (en) | 2015-08-11 | 2017-02-16 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| IL285795B (en) | 2015-08-12 | 2022-07-01 | Univ Hong Kong Chinese | Single-molecule sequencing of plasma dna |
| CN108431233B (zh) | 2015-11-11 | 2022-04-01 | 分析生物科学有限公司 | Dna文库的高效率构建 |
| CN117174167A (zh) | 2015-12-17 | 2023-12-05 | 夸登特健康公司 | 通过分析无细胞dna确定肿瘤基因拷贝数的方法 |
| US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
| WO2017165852A1 (en) | 2016-03-24 | 2017-09-28 | Biological Dynamics, Inc. | Disposable fluidic cartridge and components |
| JP7280044B2 (ja) | 2016-04-15 | 2023-05-23 | ナテラ, インコーポレイテッド | 肺癌の検出方法 |
| EP3885447B1 (en) | 2016-05-30 | 2024-01-10 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free dna in blood |
| US11200963B2 (en) | 2016-07-27 | 2021-12-14 | Sequenom, Inc. | Genetic copy number alteration classifications |
| AU2017315769B2 (en) | 2016-08-25 | 2024-02-01 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in DNA samples |
| US11854666B2 (en) * | 2016-09-29 | 2023-12-26 | Myriad Women's Health, Inc. | Noninvasive prenatal screening using dynamic iterative depth optimization |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| EP3535415A4 (en) | 2016-10-24 | 2020-07-01 | The Chinese University of Hong Kong | TUMOR DETECTION METHODS AND SYSTEMS |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| IL315032A (en) | 2016-11-30 | 2024-10-01 | Univ Hong Kong Chinese | Analysis of cell-free dna in urine and other samples |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| IL319365A (en) | 2017-01-24 | 2025-05-01 | Sequenom Inc | Methods and processes for assessing genetic variations |
| CA3051509A1 (en) | 2017-01-25 | 2018-08-02 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
| US10894976B2 (en) | 2017-02-21 | 2021-01-19 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| PT3596233T (pt) | 2017-03-17 | 2022-08-22 | Sequenom Inc | Métodos e processos para avaliação de mosaicismo genético |
| US11342047B2 (en) | 2017-04-21 | 2022-05-24 | Illumina, Inc. | Using cell-free DNA fragment size to detect tumor-associated variant |
| US10818379B2 (en) | 2017-05-08 | 2020-10-27 | Biological Dynamics, Inc. | Methods and systems for analyte information processing |
| KR102145417B1 (ko) * | 2017-05-24 | 2020-08-19 | 지니너스 주식회사 | 무세포 핵산으로부터 수득된 서열 분석 데이터에 대한 배경 대립인자의 빈도 분포를 생성하는 방법 및 이를 이용하여 무세포 핵산으로부터 변이를 검출하는 방법 |
| AU2018279073A1 (en) * | 2017-06-08 | 2020-01-16 | Nantomics, Llc | An integrative panomic approach to pharmacogenomics screening |
| JP7776099B2 (ja) | 2017-07-26 | 2025-11-26 | ザ チャイニーズ ユニバーシティー オブ ホンコン | 無細胞ウイルス核酸を用いる癌スクリーニングの強化 |
| IL319255A (en) | 2017-08-07 | 2025-04-01 | Univ Johns Hopkins | Methods and materials for cancer assessment and treatment |
| CN110021355B (zh) * | 2017-09-22 | 2021-05-04 | 深圳华大生命科学研究院 | 二倍体基因组测序片段的单倍体分型和变异检测方法和装置 |
| US11168356B2 (en) * | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
| TWI669618B (zh) * | 2017-11-24 | 2019-08-21 | 南韓商韓國美迪基因科技有限公司 | 預測疾病的方法及裝置以及計算每種疾病發生風險的加權分數的方法 |
| WO2019118926A1 (en) | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
| EP3728582A4 (en) * | 2017-12-19 | 2021-09-01 | Biological Dynamics, Inc. | METHODS AND DEVICES FOR DETECTION AND QUANTIFICATION OF ACELLULAR DNA FRAGMENTS |
| EP3727693A4 (en) | 2017-12-19 | 2021-08-25 | Biological Dynamics, Inc. | METHOD AND DEVICE FOR DETECTION OF MULTIPLE ANALYTES FROM A BIOLOGICAL SAMPLE |
| US12398389B2 (en) | 2018-02-15 | 2025-08-26 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| WO2019178277A1 (en) | 2018-03-13 | 2019-09-19 | Grail, Inc. | Anomalous fragment detection and classification |
| CN112534506B (zh) | 2018-03-15 | 2025-03-04 | 格瑞尔公司 | 组织特异性的甲基化标志物 |
| US12154661B2 (en) * | 2018-03-22 | 2024-11-26 | The Regents Of The University Of Michigan | Method and apparatus for analysis of chromatin interaction data |
| CN112654431A (zh) | 2018-04-02 | 2021-04-13 | 生物动力学公司 | 介电材料 |
| US20190316209A1 (en) | 2018-04-13 | 2019-10-17 | Grail, Inc. | Multi-Assay Prediction Model for Cancer Detection |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| CN112292458A (zh) | 2018-05-03 | 2021-01-29 | 香港中文大学 | 测量无细胞混合物特性的尺寸标记的优选末端和识别方向的分析 |
| AU2019277698A1 (en) | 2018-06-01 | 2020-11-19 | Grail, Llc | Convolutional neural network systems and methods for data classification |
| TW202013385A (zh) | 2018-06-07 | 2020-04-01 | 美商河谷控股Ip有限責任公司 | 基於差異的基因組之辨識分數 |
| WO2019237230A1 (zh) * | 2018-06-11 | 2019-12-19 | 深圳华大生命科学研究院 | 确定待测样本类型的方法及系统 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN112740239B (zh) * | 2018-10-08 | 2025-02-28 | 福瑞诺姆控股公司 | 转录因子分析 |
| US11581062B2 (en) | 2018-12-10 | 2023-02-14 | Grail, Llc | Systems and methods for classifying patients with respect to multiple cancer classes |
| TW202536188A (zh) | 2018-12-19 | 2025-09-16 | 香港中文大學 | 游離dna末端特徵 |
| WO2020132572A1 (en) | 2018-12-21 | 2020-06-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free-dna samples |
| JP7332695B2 (ja) * | 2018-12-21 | 2023-08-23 | エフ. ホフマン-ラ ロシュ アーゲー | 循環核酸からの全ゲノム配列データにおける包括的配列特徴の同定 |
| EP3938534A4 (en) | 2019-03-13 | 2023-03-29 | Grail, LLC | SYSTEMS AND METHODS FOR ENCOURAGEMENT OF CANCER DERIVATIVE FRAGMENTS BY FRAGMENT SIZE |
| TWI874374B (zh) | 2019-03-25 | 2025-03-01 | 香港中文大學 | 確定循環核酸之線性及環狀形式 |
| CN113710818A (zh) * | 2019-04-02 | 2021-11-26 | 格里尔公司 | 病毒相关联的癌症风险分层 |
| US12497662B2 (en) | 2019-04-16 | 2025-12-16 | Grail, Inc. | Systems and methods for tumor fraction estimation from small variants |
| CA3139352A1 (en) * | 2019-05-10 | 2020-11-19 | Bayer Consumer Care Ag | Identification of candidate signs indicative of an ntrk oncogenic fusion |
| WO2020247263A1 (en) | 2019-06-06 | 2020-12-10 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| CN110825819A (zh) * | 2019-09-24 | 2020-02-21 | 昆明理工大学 | 一种处理有缺失值和不平衡非小细胞肺癌数据的二分类方法 |
| WO2021108654A1 (en) | 2019-11-27 | 2021-06-03 | Grail, Inc. | Systems and methods for evaluating longitudinal biological feature data |
| IL295297A (en) | 2020-02-14 | 2022-10-01 | Univ Johns Hopkins | Methods and materials for assessing nucleic acids |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| CN114093417B (zh) * | 2021-11-23 | 2022-10-04 | 深圳吉因加信息科技有限公司 | 一种鉴定染色体臂杂合性缺失的方法和装置 |
| CN115220623B (zh) * | 2021-12-17 | 2023-12-05 | 深圳市瑞图生物技术有限公司 | 染色体图像分析方法、设备及存储介质 |
| IL317918A (en) | 2022-02-07 | 2025-02-01 | Centre For Novostics | Fragmentation for measuring mitotic and disease |
| CN114525341A (zh) * | 2022-02-24 | 2022-05-24 | 苏州宏元生物科技有限公司 | 一种同时检测肺癌和肺部感染的试剂盒 |
| WO2024003936A1 (en) | 2022-06-29 | 2024-01-04 | Raman Govindarajan | Method for detecting cancer susceptibility, early detection and predicting cancer behaviour |
| CN114898802B (zh) * | 2022-07-14 | 2022-09-30 | 臻和(北京)生物科技有限公司 | 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置 |
| AU2023397970A1 (en) * | 2022-12-12 | 2025-06-19 | Flagship Pioneering Innovations, Vi, Llc | Phased sequencing information from circulating tumor dna |
| WO2024203348A1 (ja) * | 2023-03-31 | 2024-10-03 | ソニーグループ株式会社 | 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994011531A1 (en) * | 1992-11-13 | 1994-05-26 | California Institute Of Biological Research | Identification of neoplasms by detection of genetic insertions and deletions |
| CH686982A5 (fr) | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| EP0956365A4 (en) * | 1996-08-28 | 2004-08-25 | Univ Johns Hopkins Med | METHOD FOR DETECTING CELL PROLIFERATIVE DEREGULATIONS |
| EP1158055A1 (fr) | 2000-05-26 | 2001-11-28 | Xu Qi University of Teaxs Laboratoire de Leucémie Chen | Méthode pour le diagnostic de cancers |
| US20030219802A1 (en) * | 2002-03-08 | 2003-11-27 | The Regents Of The University Of Michigan | Diagnosis and treatment of osteosarcoma |
| WO2004044225A2 (en) * | 2002-11-11 | 2004-05-27 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
| WO2005044086A2 (en) * | 2003-10-30 | 2005-05-19 | Tufts-New England Medical Center | Prenatal diagnosis using cell-free fetal dna in amniotic fluid |
| EP1531183A1 (en) | 2003-11-14 | 2005-05-18 | bioMérieux BV | Method for amplification of RNA sequences |
| JP2006094760A (ja) * | 2004-09-29 | 2006-04-13 | Canon Inc | 細胞のスクリーニング方法および口腔癌細胞検出方法 |
| DE602005009324D1 (de) | 2005-04-06 | 2008-10-09 | Maurice Stroun | Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf |
| US20070207481A1 (en) * | 2005-12-14 | 2007-09-06 | Michael Wigler | Use of roma for characterizing genomic rearrangements |
| EP1969514A2 (en) * | 2005-12-14 | 2008-09-17 | Cold Spring Harbor Laboratory | Methods for assessing probabilistic measures of clinical outcome using genomic profiling |
| FI20061136A0 (fi) * | 2006-12-19 | 2006-12-19 | Sakari Knuutila | Seulontamenetelmä |
| CN100533120C (zh) * | 2007-03-24 | 2009-08-26 | 辽宁师范大学 | 多色荧光复合扩增11个肺癌易感性相关snp位点试剂盒 |
| WO2008156827A2 (en) * | 2007-06-20 | 2008-12-24 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular grading methods for ductal carcinoma in situ |
| KR102222378B1 (ko) * | 2007-07-23 | 2021-03-04 | 더 차이니즈 유니버시티 오브 홍콩 | 핵산 서열 불균형의 결정 |
| US12180549B2 (en) * | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| US8093063B2 (en) | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
| US20100041048A1 (en) * | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| CN102272327B (zh) * | 2008-11-07 | 2015-11-25 | 赛昆塔公司 | 通过序列分析监测状况的方法 |
| US20100136560A1 (en) | 2008-12-02 | 2010-06-03 | The Johns Hopkins University | Integrated Analyses of Breast and Colorectal Cancers |
| WO2010070366A1 (en) * | 2008-12-15 | 2010-06-24 | Debreceni Egyetem | Cytometric method for the comparative analysis of the length of pcr products and uses of this method |
| CN102325901A (zh) | 2008-12-22 | 2012-01-18 | 赛卢拉有限公司 | 检测等位基因、基因组和转录物组的方法和基因型分析谱 |
| HUE061110T2 (hu) | 2009-11-05 | 2023-05-28 | Univ Hong Kong Chinese | Magzati genomelemzés anyai biológiai mintából |
| WO2011054936A1 (en) | 2009-11-06 | 2011-05-12 | The Chinese University Of Hong Kong | Size-based genomic analysis |
| EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| EP2848704B1 (en) | 2010-01-19 | 2018-08-29 | Verinata Health, Inc | Sequencing methods for prenatal diagnoses |
| WO2011103236A2 (en) | 2010-02-18 | 2011-08-25 | The Johns Hopkins University | Personalized tumor biomarkers |
| WO2011130751A1 (en) * | 2010-04-16 | 2011-10-20 | Chronix Biomedical | Breast cancer associated circulating nucleic acid biomarkers |
| WO2011149534A2 (en) * | 2010-05-25 | 2011-12-01 | The Regents Of The University Of California | Bambam: parallel comparative analysis of high-throughput sequencing data |
| US20120034603A1 (en) * | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| KR101891847B1 (ko) | 2010-11-30 | 2018-08-24 | 더 차이니즈 유니버시티 오브 홍콩 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
-
2011
- 2011-11-30 KR KR1020137016780A patent/KR101891847B1/ko active Active
- 2011-11-30 EP EP19206273.5A patent/EP3640346A1/en active Pending
- 2011-11-30 MX MX2013006075A patent/MX349568B/es active IP Right Grant
- 2011-11-30 EA EA201300649A patent/EA038374B1/ru unknown
- 2011-11-30 BR BR112013013421A patent/BR112013013421A2/pt not_active Application Discontinuation
- 2011-11-30 DK DK17168020.0T patent/DK3243910T3/da active
- 2011-11-30 CN CN201180066175.7A patent/CN103403182B/zh active Active
- 2011-11-30 TW TW110101988A patent/TWI786520B/zh active
- 2011-11-30 US US13/308,473 patent/US8741811B2/en active Active
- 2011-11-30 NZ NZ611599A patent/NZ611599A/en unknown
- 2011-11-30 CA CA2817370A patent/CA2817370C/en active Active
- 2011-11-30 AU AU2011335891A patent/AU2011335891B2/en active Active
- 2011-11-30 EP EP17168020.0A patent/EP3243910B1/en not_active Revoked
- 2011-11-30 EP EP23190213.1A patent/EP4269623A3/en active Pending
- 2011-11-30 KR KR1020207033400A patent/KR102333664B1/ko active Active
- 2011-11-30 WO PCT/AU2011/001562 patent/WO2012071621A1/en not_active Ceased
- 2011-11-30 DK DK11845367.9T patent/DK2646579T3/en active
- 2011-11-30 SG SG10201509766YA patent/SG10201509766YA/en unknown
- 2011-11-30 SG SG10202008532PA patent/SG10202008532PA/en unknown
- 2011-11-30 TW TW100144098A patent/TWI532843B/zh active
- 2011-11-30 CN CN201810817319.1A patent/CN108899091B/zh active Active
- 2011-11-30 JP JP2013541152A patent/JP6196157B2/ja active Active
- 2011-11-30 CN CN202210291074.XA patent/CN114678128A/zh active Pending
- 2011-11-30 TW TW107129009A patent/TWI719339B/zh active
- 2011-11-30 TW TW111126139A patent/TW202242133A/zh unknown
- 2011-11-30 KR KR1020217038741A patent/KR102489749B1/ko active Active
- 2011-11-30 MX MX2017009968A patent/MX370249B/es unknown
- 2011-11-30 KR KR1020237001326A patent/KR102723107B1/ko active Active
- 2011-11-30 TW TW105102252A patent/TWI642786B/zh active
- 2011-11-30 KR KR1020197032092A patent/KR102185244B1/ko active Active
- 2011-11-30 KR KR1020187023415A patent/KR102040307B1/ko active Active
- 2011-11-30 EP EP11845367.9A patent/EP2646579B1/en active Active
- 2011-11-30 MY MYPI2013001960A patent/MY169852A/en unknown
- 2011-11-30 SG SG2013038773A patent/SG190344A1/en unknown
- 2011-11-30 CN CN201510615900.1A patent/CN105243295B/zh active Active
-
2013
- 2013-05-09 IL IL226272A patent/IL226272A/en active IP Right Grant
- 2013-05-30 MX MX2019014657A patent/MX2019014657A/es unknown
- 2013-06-21 ZA ZA2013/04625A patent/ZA201304625B/en unknown
-
2014
- 2014-04-17 US US14/255,415 patent/US9965585B2/en active Active
-
2016
- 2016-01-28 IL IL243823A patent/IL243823A/en active IP Right Grant
-
2017
- 2017-03-05 IL IL250931A patent/IL250931A0/en unknown
- 2017-04-19 US US15/491,507 patent/US12002544B2/en active Active
- 2017-08-08 JP JP2017153310A patent/JP6487504B2/ja active Active
-
2019
- 2019-02-20 JP JP2019028674A patent/JP6931013B2/ja active Active
-
2021
- 2021-08-12 JP JP2021131762A patent/JP7351537B2/ja active Active
-
2023
- 2023-09-07 JP JP2023145456A patent/JP2023179458A/ja active Pending
-
2024
- 2024-05-24 US US18/674,702 patent/US20250006299A1/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| Genome Res. 2001 Jun;11(6):981-93 |
| Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4884-91 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250006299A1 (en) | Detection of genetic or molecular aberrations associated with cancer | |
| AU2022202130A1 (en) | Detection of genetic or molecular aberrations associated with cancer | |
| HK40028054A (en) | Analysis of a biological sample of an organism for chromosomal deletions or amplifications associated with cancer | |
| HK1240278A1 (en) | Determination of progress of chromosomal aberrations in an organism | |
| HK1240278B (en) | Determination of progress of chromosomal aberrations in an organism | |
| HK1190435B (en) | Detection of genetic or molecular aberrations associated with cancer | |
| HK1190435A (en) | Detection of genetic or molecular aberrations associated with cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20180814 Application number text: 1020137016780 Filing date: 20130627 |
|
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20180822 Comment text: Request for Examination of Application |
|
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20181112 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20190727 |
|
| A107 | Divisional application of patent | ||
| GRNT | Written decision to grant | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20191029 Application number text: 1020137016780 Filing date: 20130627 |
|
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20191029 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20191030 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration | ||
| PR1001 | Payment of annual fee |
Payment date: 20220915 Start annual number: 4 End annual number: 4 |
|
| PR1001 | Payment of annual fee |
Payment date: 20230918 Start annual number: 5 End annual number: 5 |
|
| PR1001 | Payment of annual fee |
Payment date: 20240919 Start annual number: 6 End annual number: 6 |