KR102032002B1 - 알루미늄 히드록시포스페이트 아주반트의 제조 방법 - Google Patents

알루미늄 히드록시포스페이트 아주반트의 제조 방법

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Publication number
KR102032002B1
KR102032002B1 KR1020147016728A KR20147016728A KR102032002B1 KR 102032002 B1 KR102032002 B1 KR 102032002B1 KR 1020147016728 A KR1020147016728 A KR 1020147016728A KR 20147016728 A KR20147016728 A KR 20147016728A KR 102032002 B1 KR102032002 B1 KR 102032002B1
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KR
South Korea
Prior art keywords
aluminum
phosphate
solution
adjuvant
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
KR1020147016728A
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English (en)
Korean (ko)
Other versions
KR20140100530A (ko
Inventor
데이빗 에스. 티리오트
패트릭 엘. 알
제임 캐논
가브리엘 엠. 로벨
Original Assignee
머크 샤프 앤드 돔 코포레이션
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Application filed by 머크 샤프 앤드 돔 코포레이션 filed Critical 머크 샤프 앤드 돔 코포레이션
Publication of KR20140100530A publication Critical patent/KR20140100530A/ko
Application granted granted Critical
Publication of KR102032002B1 publication Critical patent/KR102032002B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/36—Aluminium phosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
KR1020147016728A 2011-11-23 2012-11-19 알루미늄 히드록시포스페이트 아주반트의 제조 방법 Active KR102032002B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563213P 2011-11-23 2011-11-23
US61/563,213 2011-11-23
PCT/US2012/065741 WO2013078102A1 (en) 2011-11-23 2012-11-19 Method for preparation of aluminum hydroxyphosphate adjuvant

Publications (2)

Publication Number Publication Date
KR20140100530A KR20140100530A (ko) 2014-08-14
KR102032002B1 true KR102032002B1 (ko) 2019-10-14

Family

ID=48470220

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147016728A Active KR102032002B1 (ko) 2011-11-23 2012-11-19 알루미늄 히드록시포스페이트 아주반트의 제조 방법

Country Status (6)

Country Link
US (1) US9573811B2 (cg-RX-API-DMAC7.html)
EP (1) EP2782594B1 (cg-RX-API-DMAC7.html)
KR (1) KR102032002B1 (cg-RX-API-DMAC7.html)
ES (1) ES2729111T3 (cg-RX-API-DMAC7.html)
IN (1) IN2014CN03391A (cg-RX-API-DMAC7.html)
WO (1) WO2013078102A1 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202100130T1 (it) * 2015-06-12 2021-05-07 Biological E Ltd Metodo per la preparazione di gel di fosfato di alluminio per applicazione in formulazioni vaccinali
US20190314486A1 (en) 2016-10-21 2019-10-17 Merck Sharp & Dohme Corp. Influenza hemagglutinin protein vaccines
JP2021501144A (ja) * 2017-10-25 2021-01-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． アジュバントワクチン
US11566051B2 (en) 2018-01-29 2023-01-31 Merck Sharp & Dohme Llc Stabilized RSV F proteins and uses thereof
EP3556728A1 (en) * 2018-04-16 2019-10-23 Croda Denmark A/S Organically modified mineral micro-particles, methods of preparing the same and uses thereof
JP6677428B1 (ja) * 2018-05-23 2020-04-08 一般財団法人阪大微生物病研究会 リン酸アルミニウム化合物
WO2020081933A1 (en) * 2018-10-19 2020-04-23 Translate Bio, Inc. Pumpless encapsulation of messenger rna
CN111803627B (zh) 2019-04-11 2023-01-03 厦门万泰沧海生物技术有限公司 唑来膦酸锌微纳米颗粒佐剂的制备及作为疫苗佐剂的用途
US12419951B2 (en) 2019-05-30 2025-09-23 Xiamen University Preparation of zinc risedronate micro/nano adjuvant and use thereof as vaccine adjuvant
CN113666404B (zh) * 2021-09-23 2023-07-28 北京智飞绿竹生物制药有限公司 一种适合规模化生产的高浓度纳米级氢氧化铝佐剂配制方法
KR20230047827A (ko) * 2021-10-01 2023-04-10 에스케이바이오사이언스(주) 향상된 효능을 갖는 알루미늄계 애주번트를 제조하는 방법
KR20240147612A (ko) * 2023-03-31 2024-10-08 에스케이바이오사이언스(주) 향상된 효능을 갖는 알루미늄계 애주번트를 제조하는 방법
US20240376157A1 (en) 2023-05-08 2024-11-14 Merck Sharp & Dohme Llc Polynucleotides encoding norovirus vp1 antigens and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016252A (en) 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
FR2181426B1 (cg-RX-API-DMAC7.html) 1972-04-06 1974-12-20 Pasteur Institut
US8540955B2 (en) * 2007-07-10 2013-09-24 Wyeth Llc Process for producing aluminum phosphate
EP2430040A1 (en) 2009-05-11 2012-03-21 Novartis AG Antigen purification process for pertactin antigen
TW201136603A (en) * 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Pharm. Sci. Vol. 89, pages 311-321
Vaccine, Vol. 19. pages 275-281 (2001)

Also Published As

Publication number Publication date
ES2729111T3 (es) 2019-10-30
US9573811B2 (en) 2017-02-21
KR20140100530A (ko) 2014-08-14
WO2013078102A1 (en) 2013-05-30
IN2014CN03391A (cg-RX-API-DMAC7.html) 2015-07-03
US20140314653A1 (en) 2014-10-23
EP2782594A1 (en) 2014-10-01
EP2782594B1 (en) 2019-04-17
EP2782594A4 (en) 2015-07-29

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